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https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#1
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29667008/eco-friendly-synthesis-in-vitro-anti-proliferative-evaluation-and-3d-qsar-analysis-of-a-novel-series-of-monocationic-2-aryl-heteroaryl-substituted-6-2-imidazolinyl-benzothiazole-mesylates
#2
Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Branimir Bertoša, Irena Sović, Grace Karminski-Zamola
Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole...
April 17, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29663068/prevalence-of-colorectal-cancer-in-acute-uncomplicated-diverticulitis-and-the-role-of-the-interval-colonoscopy
#3
Yock Teck Nicholas Soh, Kai Ann Daryl Chia, Nan Zun Teo, Jian Ming Calvin Ong, Ramesh Wijaya
PURPOSE: Although computed tomography (CT) is the imaging modality of choice for diagnosing colonic diverticulitis today, there remains a risk of colorectal cancer mimicking diverticulitis due to overlapping imaging features. Current practice guidelines recommend interval colonoscopy after diverticulitis to exclude occult malignancy. Some authors have suggested that this may be unnecessary in patients with uncomplicated diverticulitis. The aim of our study was to examine the prevalence of occult colorectal cancer in patients with CT-proven acute uncomplicated diverticulitis in an Asian population...
April 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29630003/use-of-primary-anastomosis-with-diverting-ileostomy-in-patients-with-acute-diverticulitis-requiring-urgent-operative-intervention
#4
Christy E Cauley, Ruchin Patel, Liliana Bordeianou
BACKGROUND: Previous studies suggest that urgent colectomy and primary anastomosis with diversion is safe for perforated diverticulitis. Current guidelines support this approach. OBJECTIVE: The purpose of this study was to describe the use of urgent or emergent primary anastomosis with diversion in diverticulitis before the 2014 American Society of Colon and Rectal Surgeons guidelines and compare national outcomes of primary anastomosis with diversion to the Hartmann procedure...
May 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29609829/is-the-virtual-colonoscopy-a-replacement-for-optical-colonoscopy
#5
REVIEW
Andrew Guinigundo
OBJECTIVE: To examine the viability of colon cancer screening with computed tomography colonography, also known as virtual colonoscopy. DATA SOURCES: Clinical guidelines, published medical research. CONCLUSION: Virtual colonoscopy, under the right circumstances, is an accurate viable screening tool for patients who may not otherwise desire to or are not able to participate in traditional colonoscopy. IMPLICATIONS FOR NURSING PRACTICE: Nurses should be aware that routine colon cancer screening is recommended starting at age 50...
March 30, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29584752/use-of-adjuvant-chemotherapy-in-patients-with-stage-iii-colon-cancer-in-puerto-rico-a-population-based-study
#6
Karen J Ortiz-Ortiz, Guillermo Tortolero-Luna, Ruth Ríos-Motta, Alejandro Veintidós-Feliú, Robert Hunter-Mellado, Carlos R Torres-Cintrón, Tonatiuh Suárez-Ramos, Priscilla Magno
OBJECTIVE: This study aims to examine factors associated with the use of adjuvant chemotherapy and the use of oxaliplatin after curative resection in stage III colon cancer patients and assesses the effect of their use in three-year survival. METHODS: This retrospective cohort study was conducted using Puerto Rico Central Cancer Registry-Health Insurance Linkage Database. The study cohort consisted of stage III colon cancer patients with a curative surgery in the period 2008-2012...
2018: PloS One
https://www.readbyqxmd.com/read/29549740/development-and-validation-of-an-ultra-high-performance-liquid-chromatography-electrospray-tandem-mass-spectrometry-method-using-selective-derivatisation-for-the-quantification-of-two-reactive-aldehydes-produced-by-lipid-peroxidation-hne-4-hydroxy-2-e-nonenal
#7
S Chevolleau, M-H Noguer-Meireles, I Jouanin, N Naud, F Pierre, F Gueraud, L Debrauwer
Red or processed meat rich diets have been shown to be associated with an elevated risk of colorectal cancer (CRC). One major hypothesis involves dietary heme iron which induces lipid peroxidation. The quantification of the resulting reactive aldehydes (e.g. HNE and HHE) in the colon lumen is therefore of great concern since these compounds are known for their cytotoxic and genotoxic properties. UHPLC-ESI-MS/MS method has been developed and validated for HNE and HHE quantification in rat faeces. Samples were derivatised using a brominated reagent (BBHA) in presence of pre-synthesized deuterated internal standards (HNE-d11/HHE-d5), extracted by solid phase extraction, and then analysed by LC-positive ESI-MS/MS (MRM) on a TSQ Vantage mass spectrometer...
March 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29549680/bowel-wall-thickening-inquire-or-not-inquire-our-guidelines
#8
D Iadicola, P De Marco, S Bonventre, E M Grutta, G Barletta, L Licari, G Gulotta
INTRODUCTION: Bowel wall thickening is not an uncommon finding among patient undergoing abdomen CT scan. It may be caused by neoplastic, inflammatory, infectious or ischaemic conditions but also be a normal variant. Although specific radiologic patterns may direct to a precise diagnosis, occasionally misidentification may occur. Thus, in the absence of guidelines, further and not always needed diagnostic procedures (colonoscopy, esophagogastroduodenoscopy or capsule endoscopy) are performed...
January 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29541281/cdkn2a-founder-mutation-in-pancreatic-ductal-adenocarcinoma-patients-without-cutaneous-features-of-familial-atypical-multiple-mole-melanoma-fammm-syndrome
#9
Carol Cremin, Sarah Howard, Lyly Le, Aly Karsan, David F Schaeffer, Daniel Renouf, Kasmintan A Schrader
Background: Approximately 5% to 10% of pancreatic ductal adenocarcinoma (PDAC) has a hereditary basis. In most of these defined hereditary cancer syndromes, PDAC is not the predominant cancer type. Traditional criteria for publicly funded genetic testing typically require the presence of a set combination of the predominant syndrome-associated cancer types in the family history.We report the identification of a CDKN2A pathogenic variant in a PDAC-prone family without the cutaneous features of multiple moles or melanoma that are characteristic of the Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome identified in a universal testing algorithm for inherited mutations in pancreatic cancer patients...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29531469/four-cancer-cases-after-esophageal-atresia-repair-time-to-start-screening-the-upper-gastrointestinal-tract
#10
Floor Wt Vergouwe, Madeleine Gottrand, Bas Pl Wijnhoven, Hanneke IJsselstijn, Guillaume Piessen, Marco J Bruno, René Mh Wijnen, Manon Cw Spaander
Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia (72%) and gastroesophageal reflux (GER) (67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age...
March 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29509539/cervical-exenteration-guidelines-and-surgical-technique-principles
#11
Constantin Ciuce, Răzvan Scurtu, Cătălin Ciuce, Raluca Apostu, Horea Bocşe, George Dindelegan
Introduction: Neoplastic invasion of the structures of the cervical region originating from a malignant tumour developed in one of the viscera of the throat may benefit from cervical exenteration. Defined as resection of the hypopharynx, cervical oesophagus, larynx and cervical trachea, exenteration has limited indications and is mandatorily accompanied by digestive tube reconstruction. The aim of this article is to highlight the indication, surgical strategy and important surgical stages illustrated by images from personal professional experience...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29506299/-surveillance-after-treatment-of-gastrointestinal-cancer
#12
Kerstin Artzner, Nisar Peter Malek
Treatment for gastrointestinal malignancies has evolved over the past two decades. Long-term outcomes have considerably improved, however a high rate of recurrence persists. With the exception of colon cancer, clear consensus strategies with regards to post-treatment surveillance are lacking. Current surveillance practices in non-colon cancer cases are inadequately based on retrospective case analyses and expert recommendations which are not uniformly consistent.This article presents the key follow-up aspects such as recurrence frequency, timing, localization, and therapeutic efficacy for the most common gastrointestinal tumors, and summarizes current recommendations for early detection of recurrence...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29422252/achieving-high-quality-standards-in-laparoscopic-colon-resection-for-cancer-a-delphi-consensus-based-position-paper
#13
Laura Lorenzon, Alberto Biondi, Thomas Carus, Adam Dziki, Eloy Espin, Nuno Figueiredo, Marcos Gomez Ruiz, Tamas Mersich, Isacco Montroni, Pieter J Tanis, Stefan Rolf Benz, Paolo Pietro Bianchi, Matthias Biebl, Ivo Broeders, Raffaele De Luca, Paolo Delrio, Mathieu D'Hondt, Alois Fürst, Jan Grosek, Jose Flavio Guimaraes Videira, Friedrich Herbst, David Jayne, György Lázár, Danilo Miskovic, Andrea Muratore, Ole Helmer Sjo, Tom Scheinin, Ales Tomazic, Andreas Türler, Cornelius Van de Velde, Steven D Wexner, Christoph Wullstein, Wojciech Zegarski, Domenico D'Ugo
AIM: To investigate the rate of laparoscopic colectomies for colon cancer using registries and population-based studies. To provide a position paper on mini-invasive (MIS) colon cancer surgery based on the opinion of experts leader in this field. METHODS: A systematic review of the literature was conducted using PRISMA guidelines for the rate of laparoscopy in colon cancer. Moreover, Delphi methodology was used to reach consensus among 35 international experts in four study rounds...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29415287/residual-adenoma-after-cold-snare-polypectomy-for-small-colorectal-adenomas-a-prospective-clinical-study
#14
Daisuke Maruoka, Makoto Arai, Naoki Akizue, Kentaro Ishikawa, Shingo Kasamatsu, Takashi Taida, Hideaki Ishigami, Kenichiro Okimoto, Keiko Saito, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuro Katsuno, Naoya Kato
BACKGROUND: Endoscopic resection of all colonic adenomas prevents the occurrence of colon cancer and death. The European Society of Gastrointestinal Endoscopy Clinical Guideline recommends resection of all polyps predicted to be adenomas and cold snare polypectomy (CSP) for removal of adenomas ≤ 9 mm on the basis of safety; however, it also states that this recommendation lacks adequate evidence of efficacy. The residual adenoma rate after resection is an important indicator of efficacy, but there have been no reports showing this prospectively...
February 7, 2018: Endoscopy
https://www.readbyqxmd.com/read/29401168/long-term-outcomes-of-gastroenteropancreatic-neuroendocrine-tumors
#15
Weiwei Chi, Richard R P Warner, David L Chan, Simron Singh, Eva Segelov, Jonathan Strosberg, Juan Wisnivesky, Michelle K Kim
OBJECTIVES: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare but have been increasing in incidence. Limited data on the long-term outcomes of patients with these tumors are available. METHODS: In this study, we used population-based data from the National Cancer Institute to assess long-term disease-specific survival (DSS) of patients who have undergone surgery for nonmetastatic disease. All patients with NETs of the stomach, small intestine, colon, rectum, appendix, and pancreas diagnosed between 1988 and 2009 were identified from the Surveillance, Epidemiology and End Results registry...
March 2018: Pancreas
https://www.readbyqxmd.com/read/29394758/-long-term-survival-of-a-patient-with-metastatic-liver-and-para-aortic-lymph-node-cancer-from-colon-cancer-treated-with-regorafenib
#16
Nobuyuki Watanabe, Shigenori Akagi, Hiroyuki Inoue, Hiroki Nakatsuji, Hiroshi Ito, Atsushi Toma, Kenji Nakamura, Toshiya Ochiai, Eigo Otsuji
A 54-year-old man was presented at our hospital with weight loss.He diagnosed with colorectal cancer, multiple liver metastases and para-aortic lymph node metastasis.After undergoing colostomy, he was treated sequentially with mFOLFOX6 plus bevacizumab(Bmab), FOLFIRI plus Bmab or Pmab, according to the guideline.Since these chemotherapy resulted in progressive disease, regorafenib was administered as a salvage-line treatment.PET -CT showed only para-aortic lymph node swelling with high FDG uptake.Severe adverse effects were developed shortly after regorafenib treatment so he requireda reduction in dose...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394750/-examination-of-cases-of-hepatectomy-for-metastatic-colorectal-cancer
#17
Shinichiro Chino, Masanori Naito, Takeshi Kaida, Hideki Ushiku, Wataru Yamashita, Hidefumi Kubo, Yasushi Kondo, Yatsushi Nishi, Yoshihito Takahashi, Masahiko Watanabe
OBJECTIVES: Resection of liver metastasis from colorectal cancer is known to improve prognosis; therefore, surgical treatment is recommended for resectable metastases in the Japanese Society for Cancer of the Colon and Rectum Guidelines for the Treatment of Colorectal Cancer. In this study, we investigated factors that affect the prognosis of resection of such metastatic liver tumors. RESULTS: Thirty-three cases of liver resection performed during the period from 1998 to 2017 were investigated...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29385427/diagnostic-yield-of-dysplasia-in-polyp-adjacent-biopsies-for-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#18
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29381999/abdominal-surgery-in-patients-with-essential-thrombocythemia-a-case-report-and-systematic-review-of-literature
#19
Yi Zhu, HongGang Jiang, ZhiHeng Chen, BoHao Lu, JiaMing Wu
INTRODUCTION: Essential thrombocythemia/thrombocytosis (ET) is characterized by increased bleeding and thrombosis risk during the perioperative period. We report the case of a woman with ET and sigmoid colon cancer, in whom the postoperative course was complicated by anastomotic bleeding. A systematic review was conducted to seek guidance for the management of such patient in the perioperative period. METHODS: A systematic literature review was conducted using EMBASE, Medline, and PubMed databases to detect relevant English language articles...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29354876/evaluating-treatment-patterns-for-small-cell-carcinoma-of-the-colon-using-the-national-cancer-database-ncdb
#20
Sadhana Balasubramanyam, Barrett P O'Donnell, Benjamin L Musher, Pavan M Jhaveri, Michelle S Ludwig
OBJECTIVE(S): The objective of this study was to characterize the clinicopathological prognostic factors and treatment patterns for small cell carcinoma (SCC) of the colon, a rare disease without standard treatment guidelines. METHODS: We analyzed clinicopathological and treatment variables for 503 cases of histologically proven SCC colon entered into the National Cancer Database (NCDB) between 2004 and 2013. Survival curves were generated using Kaplan-Meier and compared by the log-rank test...
January 22, 2018: Journal of Gastrointestinal Cancer
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