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https://www.readbyqxmd.com/read/28078185/cxcl11-expression-by-keratinocytes-occurs-transiently-between-reaching-confluence-and-cellular-compaction
#1
Arthur C Huen, Archana Marathi, Peter K Nam, Alan Wells
Objective: To investigate whether differentiation or cellular confluence is responsible for CXCL11 expression patterns in re-epithelialization. Approach:In vitro model systems of re-epithelialization using the HaCaT keratinocyte cell line were utilized in monitoring expression of differentiation markers, including desmoplakin and various cytokeratins while evaluating for an association with chemokine CXCL11 expression. Results: CXCL11 expression was elevated in sparse culture with peak expression near the time of confluence...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28076821/2017%C3%A2-ushers-in-new-editorial-board-members-and%C3%A2-more
#2
EDITORIAL
Leslie M Loew, Beth Staehle
No abstract text is available yet for this article.
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28076681/computational-modeling-of-neurotransmitter-release-evoked-by-electrical-stimulation-non-linear-approaches-to-predicting-stimulation-evoked-dopamine-release
#3
James K Trevathan, Ali Yousefi, Hyung Ook Park, John J Bartoletta, Kip A Ludwig, Kendall H Lee, J Luis Lujan
Neurochemical changes evoked by electrical stimulation of the nervous system have been linked to both therapeutic and undesired effects of neuromodulation therapies used to treat obsessive-compulsive disorder, depression, epilepsy, Parkinson's disease, stroke, hypertension, tinnitus, and many other indications. In fact, interest in better understanding the role of neurochemical signaling in neuromodulation therapies has been a focus of recent government- and industry-sponsored programs whose ultimate goal is to usher in an era of personalized medicine by creating neuromodulation therapies that respond to real-time changes in patient status...
January 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28075129/substituted-diarylnorbornadienes-and-quadricyclanes-synthesis-photochemical-properties-and-effect-of-substituent-on-the-kinetic-stability-of-quadricyclanes
#4
Kyle J Spivack, Jesse V Walker, Maria J Sanford, Benjamin R Rupert, Andrew R Ehle, James M Tocyloski, Aaron N Jahn, Lyndsey M Shaak, Obiamaka Obianyo, Karyn M Usher, Felix E Goodson
In this Article, we present a new method for the synthesis of diarylnorbornadiene derivatives. Through the use of a two-step procedure consisting of a tandem alkene insertion-Suzuki coupling reaction followed by a DDQ dehydrogenation, we have been able to synthesize derivatives with a wide variety of substituents. We also present the results of UV-visible spectroscopy studies and kinetics experiments that show the effect of substituent on light absorption properties of the norbornadienes as well as the kinetic stability of the quadricyclanes that result from their photochemical conversion...
January 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28073482/an-overview-of-diversity-occurrence-genetics-and-toxin-production-of-bloom-forming-dolichospermum-anabaena-species
#5
REVIEW
Xiaochuang Li, Theo W Dreher, Renhui Li
The new genus name Dolichospermum, for most of the planktonic former members of the genus Anabaena, is one of the most ubiquitous bloom-forming cyanobacterial genera. Its dominance and persistence have increased in recent years, due to eutrophication from anthropogenic activities and global climate change. Blooms of Dolichospermum species, with their production of secondary metabolites that commonly include toxins, present a worldwide threat to environmental and public health. In this review, recent advances of the genus Dolichospermum are summarized, including taxonomy, genetics, bloom occurrence, and production of toxin and taste-and-odor compounds...
April 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073291/future-of-raav-gene-therapy-platform-for-rnai-gene-editing-and-beyond
#6
Paul Valdmanis, Mark A Kay
The use of recombinant adeno-associated viruses (rAAVs) ushered in a new millennium of gene transfer for therapeutic treatment of a number of conditions including congenital blindness, hemophilia, and spinal muscular atrophy (SMA). rAAV vectors have remarkable staying power from a therapeutic standpoint withstanding several ebbs and flows. As new technologies such as clustered regularly interspaced short palindromic repeat (CRISPR) genome editing emerge, it is now the delivery tool - the AAV vector - that is the stalwart...
January 10, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28071048/solvent-free-strategy-yields-size-and-shape-uniform-capsules
#7
Ana M S Costa, João F Mano
Capsules with a liquefied core were fabricated via the assembly of polymeric droplets induced by superamphiphobic surfaces. These highly repellent substrates exhibit distinct features such as (i) an easy and precise control over the particle size and shape, (ii) a high encapsulation efficiency, (iii) mild processing conditions, and (iv) the possibility to include any object in either a water or oil-based liquid core, which are not found on the current available strategies. As proof of concept, a photo-cross-linkable derivative of chitosan was used to produce the polymeric shell while a wealth variety of template cores were tested using a reversible cross-linking mechanism, interfacial gelation process or ice...
January 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28055008/early-nucleolar-disorganization-in-dictyostelium-cell-death
#8
M F Luciani, Y Song, A Sahrane, A Kosta, P Golstein
Cell death occurs in all eukaryotes, but it is still not known whether some core steps of the cell death process are conserved. We investigated this using the protist Dictyostelium. The dissection of events in Dictyostelium vacuolar developmental cell death was facilitated by the sequential requirement for two distinct exogenous signals. An initial exogenous signal (starvation and cAMP) recruited some cells into clumps. Only within these clumps did subsequent cell death events take place. Contrary to our expectations, already this initial signal provoked nucleolar disorganization and irreversible inhibition of rRNA and DNA synthesis, reflecting marked cell dysfunction...
January 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28054582/gene-therapy-approaches-for-prevention-of-retinal-degeneration-in-usher-syndrome
#9
D S Williams, A Chadha, R Hazim, D Gibbs
No abstract text is available yet for this article.
January 5, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28039415/could-nailfold-videocapillaroscopy-usher-in-a-new-era-of-preventative-disease-modifying-therapeutic-intervention-in-systemic-sclerosis-prognostic-value-of-nailfold-capillaroscopy-in-ssc
#10
https://www.readbyqxmd.com/read/28039373/a-model-of-the-superior-colliculus-predicts-fixation-locations-during-scene-viewing-and-visual-search
#11
Hossein Adeli, Françoise Vitu, Gregory J Zelinsky
: Modern computational models of attention predict fixations using saliency maps and target maps, which prioritize locations for fixation based on feature contrast and target goals, respectively. But while many such models are biologically plausible, none have looked to the oculomotor system for design constraints or parameter specification. Conversely, while most models of saccade programming are tightly coupled to underlying neurophysiology, none have been tested using real-world stimuli and tasks...
December 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28035529/hereditary-retinal-dystrophy
#12
Thomas C Hohman
As our understanding of the genetic basis for inherited retinal disease has expanded, gene therapy has advanced into clinical development. When the gene mutations associated with inherited retinal dystrophies were identified, it became possible to create animal models in which individual gene were altered to match the human mutations. The retina of these animals were then characterized to assess whether the mutated genes produced retinal phenotypes characteristic of disease-affected patients. Following the identification of a subpopulation of patients with the affected gene and the development of techniques for the viral gene transduction of retinal cells, it has become possible to deliver a copy of the normal gene into the retinal sites of the mutated genes...
December 30, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28031719/potential-role-of-immunotherapy-in-advanced-non-small-cell-lung-cancer
#13
REVIEW
Ramon Andrade de Mello, Ana Flávia Veloso, Paulo Esrom Catarina, Sara Nadine, Georgios Antoniou
Immuno checkpoint inhibitors have ushered in a new era with respect to the treatment of advanced non-small-cell lung cancer. Many patients are not suitable for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (eg, gefitinib, erlotinib, and afatinib) or with anaplastic lymphoma kinase inhibitors (eg, crizotinib and ceritinib). As a result, anti-PD-1/PD-L1 and CTLA-4 inhibitors may play a novel role in the improvement of outcomes in a metastatic setting. The regulation of immune surveillance, immunoediting, and immunoescape mechanisms may play an interesting role in this regard either alone or in combination with current drugs...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031293/the-roles-of-ush1-proteins-and-pdz-domain-containing-ush-proteins-in-ush2-complex-integrity-in-cochlear-hair-cells
#14
Junhuang Zou, Qian Chen, Ali Almishaal, Pranav Dinesh Mathur, Tihua Zheng, Cong Tian, Qing Y Zheng, Jun Yang
Usher syndrome (USH) is the most common cause of inherited deaf-blindness, manifested as USH1, USH2 and USH3 clinical types. The protein products of USH2 causative and modifier genes, USH2A, ADGRV1, WHRN and PDZD7, interact to assemble a multiprotein complex at the ankle link region of the mechanosensitive stereociliary bundle in hair cells. Defects in this complex cause stereociliary bundle disorganization and hearing loss. The four USH2 proteins also interact in vitro with USH1 proteins including myosin VIIa, USH1G (SANS), CIB2 and harmonin...
December 28, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28027199/the-combination-of-resveratrol-and-high-fluence-light-emitting-diode-red-light-produces-synergistic-photobotanical-inhibition-of-fibroblast-proliferation-and-collagen-synthesis-a-novel-treatment-for-skin-fibrosis
#15
Andrew Mamalis, Jared Jagdeo
BACKGROUND: Skin fibrosis is a debilitating condition that significantly impacts patient quality of life. Ultraviolet phototherapy is currently used to treat several diseases featuring skin fibrosis. High-fluence light-emitting diode-generated red light (HF-LED-RL) does not cause DNA damage associated with skin cancer, and it is generally regarded as safe, portable, and cost-effective. Early clinical observations suggest that LED-generated light may possess antifibrotic effects, although these findings are largely unexplored...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28009060/identifying-people-at-higher-risk-of-melanoma-across-the-u-k-a-primary-care-based-electronic-survey
#16
J A Usher-Smith, A P Kassianos, J D Emery, G A Abel, Z Teoh, S Hall, R D Neal, P Murchie, F M Walter
BACKGROUND: Melanoma incidence is rising rapidly worldwide among white populations. Defining higher-risk populations using risk prediction models may help targeted screening and early detection approaches. OBJECTIVES: To assess the feasibility of identifying people at higher risk of melanoma using the Williams self-assessed clinical risk estimation model in U.K. primary care. METHODS: We recruited participants from the waiting rooms of 22 general practices covering a total population of > 240 000 in three U...
December 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/28005542/governance-must-dive-into-organizations-to-make-a-real-difference-comment-on-governance-government-and-the-search-for-new-provider-models
#17
Jean-Louis Denis, Susan Usher
In their 2016 article, Saltman and Duran provide a thoughtful examination of the governance challenges involved in different care delivery models adopted in primary care and hospitals in two European countries. This commentary examines the limited potential of structural changes to achieve real reform and considers that, unless governance arrangements actually succeed in penetrating organizations, they are unlikely to improve care. It proposes three sets of levers influenced by governance that have potential to influence what happens at the point of care: harnessing the autonomy and expertise of professionals at a collective level to work towards better safety and quality; creating enabling contexts for cross-fertilization of clinical and organizational expertise, notably through teamwork; and patient and public engagement to achieve greater agreement on improvement priorities and overcome provider/manager tensions...
July 3, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28003808/microbiome-selection-could-spur-next-generation-plant-breeding-strategies
#18
Murali Gopal, Alka Gupta
"No plant is an island too…" Plants, though sessile, have developed a unique strategy to counter biotic and abiotic stresses by symbiotically co-evolving with microorganisms and tapping into their genome for this purpose. Soil is the bank of microbial diversity from which a plant selectively sources its microbiome to suit its needs. Besides soil, seeds, which carry the genetic blueprint of plants during trans-generational propagation, are home to diverse microbiota that acts as the principal source of microbial inoculum in crop cultivation...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28003353/staphylococcus-aureus-in-the-icu-are-these-golden-grapes-ripe-for-a-new-approach
#19
EDITORIAL
Georgia R Sampedro, Juliane Bubeck Wardenburg
Staphylococcus aureus is leading cause of infection in the setting of critical illness and injury. This pathogen causes life-threatening infection in otherwise healthy individuals, and also complicates the clinical course of patients requiring intensive care as a result of their primary medical or surgical disease processes. S. aureus infection in the intensive care unit (ICU) most commonly manifests as sepsis, ventilator-associated pneumonia, and infection of surgical sites and indwelling medical devices. With the epidemic spread of methicillin-resistant S...
December 21, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28000903/pluripotent-human-stem-cells-standing-on-the-shoulders-of-giants
#20
Ivan Damjanov, Peter W Andrews
The advent of human pluripotent stem cells, with the first derivation of human embryonic stem cells in 1998, and of human induced pluripotent stem cells in 2007, has ushered in an era of considerable excitement about the prospects of using these cells to develop new opportunities for healthcare, from their potential for regenerative medicine to their use as tools for studying the cellular basis of many diseases and the discovery of new drugs. But as with the flowering of many new areas in science, the biology of human pluripotent stem cells has its roots in a long history of, sometimes, less fêted research...
2016: International Journal of Developmental Biology
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