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https://www.readbyqxmd.com/read/28426314/the-influence-of-college-attendance-on-risk-for-marijuana-initiation-in-the-united-states-1977-to-2015
#1
Richard A Miech, Megan E Patrick, Patrick M O'Malley, Lloyd D Johnston
OBJECTIVES: To examine a potential increase in marijuana initiation among US college students as compared with their age peers not in college before and after 2013, a watershed year for increasing tolerance of marijuana use in the United States. METHODS: Data come from the Monitoring the Future study, which has followed longitudinal panels drawn from annual nationally representative, baseline samples of 12th-grade students starting with the class of 1976. We studied panel members aged 19 to 22 years who had never used marijuana by 12th grade between 1977 and 2015...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28421424/erratum-to-replacement-of-marine-fish-oil-with-de-novo-omega-3-oils-from-transgenic-camelina-sativa-in-feeds-for-gilthead-sea-bream-sparus-aurata-l
#2
Mónica B Betancor, M Sprague, D Montero, S Usher, O Sayanova, P J Campbell, J A Napier, M J Caballero, M Izquierdo, D R Tocher
No abstract text is available yet for this article.
April 18, 2017: Lipids
https://www.readbyqxmd.com/read/28403232/an-oil-containing-epa-and-dha-from-transgenic-camelina-sativa-to-replace-marine-fish-oil-in-feeds-for-atlantic-salmon-salmo-salar-l-effects-on-intestinal-transcriptome-histology-tissue-fatty-acid-profiles-and-plasma-biochemistry
#3
Mónica B Betancor, Keshuai Li, Matthew Sprague, Tora Bardal, Olga Sayanova, Sarah Usher, Lihua Han, Kjell Måsøval, Ole Torrissen, Johnathan A Napier, Douglas R Tocher, Rolf Erik Olsen
New de novo sources of omega 3 (n-3) long chain polyunsaturated fatty acids (LC-PUFA) are required as alternatives to fish oil in aquafeeds in order to maintain adequate levels of the beneficial fatty acids, eicosapentaenoic and docosahexaenoic (EPA and DHA, respectively). The present study investigated the use of an EPA+DHA oil derived from transgenic Camelina sativa in Atlantic salmon (Salmo salar) feeds containing low levels of fishmeal (35%) and fish oil (10%), reflecting current commercial formulations, to determine the impacts on tissue fatty acid profile, intestinal transcriptome, and health of farmed salmon...
2017: PloS One
https://www.readbyqxmd.com/read/28385362/twenty-years-after-how-aberration-correction-in-the-stem-truly-placed-a-a-synchrotron-in-a-microscope
#4
Quentin M Ramasse
Nearly two decades have passed since the Electron Microscopy and Analysis Group (EMAG) Conference was held in Cambridge in 1997, during which two seminal lectures were delivered that would influence the future of the U.K. electron microscopy community. With "Aberration correction in the STEM", O.L. Krivanek and co-workers ushered in the era of probe-corrected scanning transmission electron microscopy, a powerful technology that L.M. Brown urged the community at large to embrace, arguing that it would be akin to placing "A Synchrotron in a Microscope"...
April 1, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28383637/data-access-and-sharing-are-we-being-transparent-about-clinical-research-let-s-do-what-s-right-for-patients
#5
Prof F W Rockhold
Calls for greater transparency and "open data access" in clinical research are widespread, from sources including the Executive Office of the President, which in 2013 called for increased access to the results of federally funded research. In 2015, The Institute of Medicine issued a report advocating for a multi-stakeholder effort to foster responsible data sharing, and there are many others. Open science is good for researchers, good for innovation, and good for patients. The question at the center of the open-science efforts for clinical trials should not be whether data should be shared, but rather how we can usher in responsible methods for doing so...
April 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28382538/treatment-of-philadelphia-chromosome-positive-acute-lymphocytic-leukemia
#6
REVIEW
Aaron Ronson, Ariella Tvito, Jacob M Rowe
Opinion statementOver the past 15 years, the landscape of Ph+ ALL has changed dramatically. No longer the most dreaded form of acute leukemia, the advent of tyrosine kinase inhibitors (TKIs) has ushered in a new era, as TKIs have become the backbone of any treatment regimen for Ph+ ALL. A greater number achieve a complete remission allowing for more patients to get the transplant, although probably less patients need a transplant. For the first time in decades, there is hope for older patients with Ph+ ALL...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28382120/outcomes-of-late-implantation-in-usher-syndrome-patients
#7
Ana Cristina H Hoshino, Agustina Echegoyen, Maria Valéria Schmidt Goffi-Gomez, Robinson Koji Tsuji, Ricardo Ferreira Bento
Introduction Usher syndrome (US) is an autosomal recessive disorder characterized by hearing loss and progressive visual impairment. Some deaf Usher syndrome patients learn to communicate using sign language. During adolescence, as they start losing vision, they are usually referred to cochlear implantation as a salvage for their new condition. Is a late implantation beneficial to these children? Objective The objective of this study is to describe the outcomes of US patients who received cochlear implants at a later age...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28372929/cystic-fibrosis-in-the-era-of-precision-medicine
#8
REVIEW
Shruti M Paranjape, Peter J Mogayzel
The treatment of people with cystic fibrosis (CF) has been transformed by the availability of drugs that target the basic chloride defect in the disease. The use of drugs that target specific molecular defects embodies the goals of precision medicine, which incorporate preventive and therapeutic strategies and takes into account differences among individuals. However, the entirety of CF care, from diagnosis to understanding the clinical phenotype and developing a therapeutic strategy, depends on taking into account individual characteristics to achieve optimal outcomes...
March 9, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28371430/the-cognitive-science-of-sketch-worksheets
#9
Kenneth D Forbus, Maria Chang, Matthew McLure, Madeline Usher
Computational modeling of sketch understanding is interesting both scientifically and for creating systems that interact with people more naturally. Scientifically, understanding sketches requires modeling aspects of visual processing, spatial representations, and conceptual knowledge in an integrated way. Software that can understand sketches is starting to be used in classrooms, and it could have a potentially revolutionary impact as the models and technologies become more advanced. This paper looks at one such effort, Sketch Worksheets, which have been used in multiple classroom experiments already, with students ranging from elementary school to college...
March 29, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28368373/is-myeloablative-dose-intensity-necessary-in-allogeneic-hematopoietic-cell-transplantation-for-lymphomas
#10
REVIEW
M A Kharfan-Dabaja, N El-Jurdi, E Ayala, A S Kanate, B N Savani, M Hamadani
The advent of novel immunotherapy and tyrosine kinase inhibitors has ushered a new era in the treatment of Hodgkin and non-Hodgkin lymphomas. Allogeneic hematopoietic cell transplantation remains, however, a vital component in the management and potential cure of lymphomas, especially in the relapsed setting. Considering the biological and clinical heterogeneity of various subtypes of lymphomas, the optimal intensity of conditioning regimens remains controversial. Reduced intensity conditioning regimens have broadened applicability of the procedure to older and frail patients...
April 3, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28366271/targeted-therapies-in-the-treatment-of-urothelial-cancers
#11
REVIEW
Jeanny B Aragon-Ching, Donald L Trump
Progress has been slow in systemic management of locally advanced and metastatic bladder cancer over the past 20 years. However, the recent approval of immunotherapy with atezolizumab and nivolumab for second-line salvage therapy may usher in an era of more rapid improvement. Systemic treatment is suboptimal and is an area of substantial unmet medical need. The recent findings from The Cancer Genome Atlas project revealed promising pathways that may be amenable to targeted therapies. Promising results with treatment using vascular endothelial growth factor inhibitors such as ramucirumab, sunitinib or bevacizumab, and human epidermal growth factor receptor 2 targeted therapies, epidermal growth factor receptor inhibitors, and fibroblast growth factor receptor inhibitors, are undergoing clinical trials and are discussed later...
March 30, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28364581/self-reported-confidence-in-patient-safety-knowledge-among-australian-undergraduate-nursing-students-a-multi-site-cross-sectional-survey-study
#12
Kim Usher, Cindy Woods, Glenda Parmenter, Marie Hutchinson, Judy Mannix, Tamara Power, Wendy Chaboyer, Sharon Latimer, Jane Mills, Lesley Siegloff, Debra Jackson
BACKGROUND: Patient safety is critical to the provision of quality health care and thus is an essential component of nurse education. OBJECTIVE: To describe first, second and third year Australian undergraduate nursing students' confidence in patient safety knowledge acquired in the classroom and clinical settings across the three years of the undergraduate nursing program. DESIGN: A cross-sectional online survey conducted in 2015. SETTING: Seven Australian universities with campuses across three states (Queensland, New South Wales, South Australia)...
March 25, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28356008/the-evolutionary-tale-and-future-directions-of-aromatase-inhibitors-in-breast-carcinoma
#13
Dipanjan Bhattacharjee, Meena K Kumari, S Avin, Mohan V Babu Amberkar
Aromatase inhibitors have often been likened to that of 'medical scalpels' for the treatment of breast carcinoma. By inhibiting the singular step of aromatisation, they have proven to be extremely effective allies in the treatment of breast cancer among postmenopausal women. However, their relevance soon may not be limited to the post-menopausal age group alone. Recent studies have hinted at their utility amongst the pre-menopausal women; combined with ovarian ablation techniques, aromatase inhibitors may prove to be equally effective and more, as compared to tamoxifen in this age-group...
March 27, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28351335/prostate-specific-membrane-antigen-directed-nanoparticle-targeting-for-extreme-nearfield-ablation-of-prostate-cancer-cells
#14
Seung S Lee, Philip Jr Roche, Paresa N Giannopoulos, Elliot J Mitmaker, Michael Tamilia, Miltiadis Paliouras, Mark A Trifiro
Almost all biological therapeutic interventions cannot overcome neoplastic heterogeneity. Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. Multi-walled carbon nanotubes offer a number of unique properties: chemical stability, photonic properties including efficient light absorption, thermal conductivity, and extensive surface area availability for covalent chemical ligation. When combined together with a targeting moiety such as an antibody or small molecule, one can deliver highly localized temperature increases and cause extensive cellular damage...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28346292/bilateral-labyrinthine-and-internal-auditory-canal-enhancement-in-an-infant-with-severe-labyrinthine-dysplasia-a-previously-unreported-phenomenon
#15
Charles L Anzalone, Mai Lan Ho, Neil S Patel, Lisa A Schimmenti, Melissa D DeJong, Matthew L Carlson
OBJECTIVE: To describe a novel case of congenital profound bilateral sensorineural hearing loss in a patient with bilateral nodular internal auditory canal and labyrinthine enhancement and temporal bone dysplasia. PATIENTS: A 76-day-old female was referred to the authors' center for evaluation of congenital deafness. Behavioral observations and objective audiometric evaluation demonstrated bilateral profound sensorineural hearing loss and a comprehensive multidisciplinary evaluation identified compound heterozygous pathogenic variants in MYO7A, a gene associated with Usher Syndrome Type 1B or DFNB2...
March 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28337072/precision-metagenomics-rapid-metagenomic-analyses-for-infectious-disease-diagnostics-and-public-health-surveillance
#16
Ebrahim Afshinnekoo, Chou Chou, Noah Alexander, Sofia Ahsanuddin, Audrey N Schuetz, Christopher E Mason
Next-generation sequencing (NGS) technologies have ushered in the era of precision medicine, transforming the way we treat cancer patients and diagnose disease. Concomitantly, the advent of these technologies has created a surge of microbiome and metagenomic studies over the last decade, many of which are focused on investigating the host-gene-microbial interactions responsible for the development and spread of infectious diseases, as well as delineating their key role in maintaining health. As we continue to discover more information about the etiology of infectious diseases, the translational potential of metagenomic NGS methods for treatment and rapid diagnosis is becoming abundantly clear...
April 2017: Journal of Biomolecular Techniques: JBT
https://www.readbyqxmd.com/read/28336875/nico%C3%A2-o%C3%A2-based-supercapacitor-nanomaterials
#17
REVIEW
Chenggang Wang, E Zhou, Weidong He, Xiaolong Deng, Jinzhao Huang, Meng Ding, Xianqi Wei, Xiaojing Liu, Xijin Xu
In recent years, the research on supercapacitors has ushered in an explosive growth, which mainly focuses on seeking nano-/micro-materials with high energy and power densities. Herein, this review will be arranged from three aspects. We will summarize the controllable architectures of spinel NiCo₂O₄ fabricated by various approaches. Then, we introduce their performances as supercapacitors due to their excellent electrochemical performance, including superior electronic conductivity and electrochemical activity, together with the low cost and environmental friendliness...
February 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28326470/targeted-treatment-of-brain-metastases
#18
REVIEW
Nicole Shonka, Vyshak Alva Venur, Manmeet S Ahluwalia
PURPOSE OF REVIEW: Brain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients. RECENT FINDINGS: The advent of targeted therapy has ushered in an era of increased hope for patients with brain metastases. The most common malignancies that result in brain metastases-melanoma, lung cancer, and breast cancer, often have actionable mutations, which make them good candidates for targeted systemic therapy...
April 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28318121/high-performance-doped-silver-films-overcoming-fundamental-material-limits-for-nanophotonic-applications
#19
Cheng Zhang, Nathaniel Kinsey, Long Chen, Chengang Ji, Mingjie Xu, Marcello Ferrera, Xiaoqing Pan, Vladimir M Shalaev, Alexandra Boltasseva, L Jay Guo
The field of nanophotonics has ushered in a new paradigm of light manipulation by enabling deep subdiffraction confinement assisted by metallic nanostructures. However, a key limitation which has stunted a full development of high-performance nanophotonic devices is the typical large losses associated with the constituent metals. Although silver has long been known as the highest quality plasmonic material for visible and near infrared applications, its usage has been limited due to practical issues of continuous thin film formation, stability, adhesion, and surface roughness...
March 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28298101/acetonitrile-cluster-solvation-in-a-cryogenic-ethane-methane-propane-liquid-implications-for-titan-lake-chemistry
#20
L René Corrales, Thomas D Yi, Samantha K Trumbo, David Shalloway, Jonathan I Lunine, David A Usher
The atmosphere of Titan, Saturn's largest moon, exhibits interesting UV- and radiation-driven chemistry between nitrogen and methane, resulting in dipolar, nitrile-containing molecules. The assembly and subsequent solvation of such molecules in the alkane lakes and seas found on the moon's surface are of particular interest for investigating the possibility of prebiotic chemistry in Titan's hydrophobic seas. Here we characterize the solvation of acetonitrile, a product of Titan's atmospheric radiation chemistry tentatively detected on Titan's surface [H...
March 14, 2017: Journal of Chemical Physics
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