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neonatal convulsions

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https://www.readbyqxmd.com/read/28211644/healthcare-professionals-and-pharmacovigilance-of-pediatric-adverse-drug-reactions-a-5-year-analysis-of-adverse-events-reporting-system-database-of-the-food-and-drug-administration
#1
Caterina Bigi, Marco Tuccori, Guido Bocci
BACKGROUND: To analyze the Adverse Events Reporting System (AERS) database of the Food and Drug Administration (FDA), investigating the characteristics of pediatric adverse drug reactions (ADRs) and describing the effective participation of healthcare professionals in the reporting activity. METHODS: Reports of ADRs were obtained from the FDA website. Only ADRs in pediatric subjects (divided by age, by country and by professional category) were included into the analysis...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28123337/a-harmful-traditional-practice-in-newborns-with-adrenocorticotropic-hormone-resistance-syndrome-branding
#2
Osman Baştuğ, Levent Korkmaz, Sabriye Korkut, Hülya Halis, Tamer Güneş, Selim Kurtoğlu
Branding refers to a traditional practice of creating 'therapeutic' burns with hot iron rods over the skin in order to treat various diseases. Although branding is a harmful practice for the body, it has been used for various illnesses including physiologic jaundice in newborns, pneumonia, and convulsions. It causes serious morbidity and delays seeking proper medical care in neonates. Innovations of modern medicine and the use of evidence-based medicine should be preferred instead of these traditional practices...
December 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28100327/-intermittent-convulsions-for-1-5-years-and-psychomotor-retardation-in-a-girl
#3
Li Yang, Yu-Fen Li, Li-Yun Xu, Na Xu, Yu-Zeng Han, Jun-Lin Wang, Ji-Guo Song, Ying Hua, Li-Ping Zhu
The study reports a girl with pyridoxine-dependent epilepsy. The girl was admitted at the age of 2 years because of intermittent convulsions for 1.5 years and psychomotor retardation. She had a history of "hypoxia" in the neonatal period. At the age of 5 months recurrent epileptic seizures occurred. The child was resistant to antiepileptic drugs, and had many more seizures when she got cold or fever. She also had a lot of convulsive status epilepticus. No discharges were found during several video-EEG monitorings...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28009338/atrial-arrhythmia-after-newborn-eye-exam-to-caffeine-or-not-to-caffeine
#4
A Ahmad, T Mondal, B Klein
Mydriatic drops are routinely administered to premature neonates to screen for retinopathy of prematurity. Adverse anticholinergic side effects, particularly convulsions and tachycardia have been reported in the pediatric age group following instillation of mydriatics for diagnostic fundus examination [1, 2]. Caffeine is frequently used for apnea of prematurity. In the neonatal intensive care unit, the combined use of caffeine and mydriatic drops is a common practice. Here we report two cases of atrial arrhythmias after neonatal eye exam that improved with conservative management...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27984050/influence-of-tetramethylenedisulfotetramine-on-synchronous-calcium-oscillations-at-distinct-developmental-stages-of-hippocampal-neuronal-cultures
#5
Zhengyu Cao, Jian Xu, Susan Hulsizer, Yanjun Cui, Yao Dong, Isaac N Pessah
The spatial and temporal patterns of spontaneous synchronous Ca(2+) oscillations (SCOs) regulate physiological pathways that influence neuronal development, excitability, and health. Hippocampal neuronal cultures (HN) and neuron/glia co-cultures (HNG) produced from neonatal mice were loaded with Fluo-4/AM and SCOs recorded in real-time using a Fluorescence Imaging Plate Reader at different developmental stages in vitro. HNG showed an earlier onset of SCOs, with low amplitude and low frequency SCOs at 4days in vitro (DIV), whereas HN were quiescent at this point...
January 2017: Neurotoxicology
https://www.readbyqxmd.com/read/27875769/status-epilepticus-in-pregnant-women-with-epilepsy-after-valproate-adjustment-a-case-series
#6
Mengqian Wu, Nanya Hao, Bo Yan, Xiaosa Chi, Dong Zhou
PURPOSE: Valproate is an effective wide-spectrum anti-epileptic drug that is also known to be teratogenic. Its administration in epileptic women remains controversial. This report aims to draw more attention to valproate adjustment before and during pregnancy. METHODS: We collected medical records of pregnant women with epilepsy at West China Hospital in Chengdu, China who developed status epilepticus during pregnancy after valproate withdrawal or reduction in dose from January 2013 to July 2015...
December 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27782863/knowledge-of-neonatal-danger-signs-among-mothers-attending-well-baby-clinic-in-nakuru-central-district-kenya-cross-sectional-descriptive-study
#7
Elizabeth Gathoni Kibaru, Amos Magembe Otara
BACKGROUND: Neonatal mortality has remained high in Kenya despite various efforts being applied to reduce this negative trend. Early detection of neonatal illness is an important step towards improving new born survival. Toward this end there is need for the mothers to be able to identify signs in neonates that signifies severe neonatal illnesses. The objective of the study was to determine the level of knowledge of mothers attending well baby clinics on postnatal neonatal danger signs and determine the associated factors...
October 25, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27681486/vitamin-a-supplementation-for-the-prevention-of-morbidity-and-mortality-in-infants-one-to-six-months-of-age
#8
Aamer Imdad, Zunirah Ahmed, Zulfiqar A Bhutta
BACKGROUND: Vitamin A deficiency is a significant public health problem in low- and middle-income countries. Vitamin A supplementation provided to infants less than six months of age is one of the strategies to improve the nutrition of infants at high risk of vitamin A deficiency and thus potentially reduce their mortality and morbidity. OBJECTIVES: To evaluate the effect of synthetic vitamin A supplementation in infants one to six months of age in low- and middle-income countries, irrespective of maternal antenatal or postnatal vitamin A supplementation status, on mortality, morbidity and adverse effects...
September 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27612889/clinical-profile-and-biochemical-abnormalities-of-neonatal-seizure-at-nicu-of-a-tertiary-care-hospital
#9
M N Islam, M A Hossain, L Yeasmin, A Dutta, F Ahmad, R H Khan
Seizures are most common neurological emergency in the neonatal period and present as a diagnostic and therapeutic challenge to clinicians worldwide. This prospective observational study was conducted in the Neonatal Intensive Care Unit of Mymensingh Medical College Hospital from January 2015 to March 2015. Total 318 patients were enrolled in the study who presented with convulsion. Most of the patients were term (72.95%) and birth weight was normal (77.3%). Around 75% patients were delivered at home. Most common causes of convulsion were Perinatal Asphyxia (78%) followed by Septicemia, Hypoglycemia and Meningitis in order of frequency...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27557950/neonatal-domoic-acid-alters-in-vivo-binding-of-11-c-yohimbine-to-%C3%AE-2-adrenoceptors-in-adult-rat-brain
#10
Majken B Thomsen, Thea P Lillethorup, Steen Jakobsen, Erik H Nielsen, Mette Simonsen, Gregers Wegener, Anne M Landau, R Andrew Tasker
RATIONALE: Epilepsy is a debilitating seizure disorder that affects approximately 50 million people. Noradrenaline reduces neuronal excitability, has anticonvulsant effects and is protective against seizure onset. OBJECTIVE: We investigated the role of α2-adrenoceptors in vivo in a neonatal domoic acid (DOM) rat model of epilepsy. METHODS: We injected male Sprague-Dawley rats daily from postnatal day 8-14 with saline or one of two sub-convulsive doses, 20 μg/kg (DOM20) or 60 μg/kg (DOM60) DOM, an AMPA/kainate receptor agonist...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27472147/vacuum-extraction-in-fetal-macrosomia-and-risk-of-neonatal-complications-a-population-based-cohort-study
#11
Katarina Åberg, Mikael Norman, Karin Pettersson, Cecilia Ekéus
INTRODUCTION: High birthweight is associated with complicated childbirth. The aim of the present study was to investigate the association between birthweight, mode of delivery, and neonatal complications among infants born at term with a birthweight ≥3000 g. MATERIAL AND METHODS: This population-based cohort study used data from the Swedish Medical Birth Register from 1999 to 2012, including 1 030 775 births at >36 completed weeks. Exposure was mode of delivery, categorized into non-instrumental vaginal delivery (VD), emergency cesarean section (CS), vacuum extraction (VE) or cesarean section following attempted vacuum extraction (VE + CS), and birthweight was divided into five categories (3000-3999 g, 4000-4499 g, 4500-4999 g, and ≥5000 g)...
October 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27466191/neurodevelopmental-alterations-and-seizures-developed-by-mouse-model-of-infantile-hypophosphatasia-are-associated-with-purinergic-signalling-deregulation
#12
Álvaro Sebastián-Serrano, Tobias Engel, Laura de Diego-García, Luis A Olivos-Oré, Marina Arribas-Blázquez, Carlos Martínez-Frailes, Carmen Pérez-Díaz, José Luis Millán, Antonio R Artalejo, María Teresa Miras-Portugal, David C Henshall, Miguel Díaz-Hernández
Hypomorphic mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme, ALPL in human or Akp2 in mice, cause hypophosphatasia (HPP), an inherited metabolic bone disease also characterized by spontaneous seizures. Initially, these seizures were attributed to the impairment of GABAergic neurotransmission caused by altered vitamin B6 (vit-B6) metabolism. However, clinical cases in human newborns and adults whose convulsions are refractory to pro-GABAergic drugs but controlled by the vit-B6 administration, suggest that other factors are involved...
October 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27446241/paediatric-virology-in-the-hippocratic-corpus
#13
Ioannis N Mammas, Demetrios A Spandidos
Hippocrates (Island of Kos, 460 B.C.-Larissa, 370 B.C.) is the founder of the most famous Medical School of the classical antiquity. In acknowledgement of his pioneering contribution to the new scientific field of Paediatric Virology, this article provides a systematic analysis of the Hippocratic Corpus, with particular focus on viral infections predominating in neonates and children. A mumps epidemic, affecting the island of Thasos in the 5th century B.C., is described in detail. 'Herpes', a medical term derived from the ancient Greek word 'ἕρπειν', meaning 'to creep' or 'crawl', is used to describe the spreading of cutaneous lesions in both childhood and adulthood...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27404120/immediate-versus-deferred-delivery-of-the-preterm-baby-with-suspected-fetal-compromise-for-improving-outcomes
#14
REVIEW
Sarah J Stock, Leanne Bricker, Jane E Norman, Helen M West
BACKGROUND: Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity. OBJECTIVES: To assess the effects of immediate versus deferred delivery of preterm babies with suspected fetal compromise on neonatal, maternal and long-term outcomes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2016) and reference lists of retrieved studies...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27347070/case-report-an-adult-onset-type-ii-citrin-deficiency-patient-in-the-emergency-department
#15
Lujia Tang, Liang Chen, Hairong Wang, Lihua Dai, Shuming Pan
Mutations in the solute carrier family 25 (SLC25A13) gene may result in neonatal intrahepatic cholestasis caused by citrin deficiency and/or adult-onset type II citrullinemia. These conditions are inherited in an autosomal recessive manner. The current case report describes a 43-year-old man who presented with sudden delirium and upper limb weakness. Upon admission, the patient was fully conscious and alert but later lost consciousness subsequent to a sudden convulsive seizure. Hyperammonemia was detected and analysis of the SLC25A13 gene identified an 851del4 mutation...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27334642/concussive-convulsions-a-youtube-video-analysis
#16
Dalma Tényi, Csilla Gyimesi, Réka Horváth, Norbert Kovács, Hajnalka Ábrahám, Gergely Darnai, András Fogarasi, András Büki, József Janszky
OBJECTIVE: To analyze seizure-like motor phenomena immediately occurring after concussion (concussive convulsions). METHODS: Twenty-five videos of concussive convulsions were obtained from YouTube as a result of numerous sports-related search terms. The videos were analyzed by four independent observers, documenting observations of the casualty, the head injury, motor symptoms of the concussive convulsions, the postictal period, and the outcome. RESULTS: Immediate responses included the fencing response, bear hug position, and bilateral leg extension...
August 2016: Epilepsia
https://www.readbyqxmd.com/read/27276866/case-report-of-an-infant-with-severe-vitamin-d-deficiency-rickets-manifested-as-hypocalcemic-seizures
#17
Biljana Vuletić, Slavica Marković, Zoran Igrutinović, Radlović Vladimir, Zorica Rasković, Aleksandra Simović
INTRODUCTION: Hypocalcemic seizures are uncommon in the post-neonatal period. We report an infant with hypocalcemic seizures caused by severe deficiency of vitamin D. CASE OUTLINE: A five-month-old male infant was admitted to hospital in March 2013 with recurrent generalized afebrile seizures resistant to clonazepam therapy. At the clinical examination, the infant showed characteristic rachitic signs, so that after a blood sample was taken for laboratory testing, the infant was given infusion of 2 ml/kg of 10% of calcium gluconate at a rate of 0...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/27245342/the-return-of-congenital-rickets-are-we-missing-occult-cases
#18
REVIEW
Abdelwahab T H Elidrissy
Congenital rickets is the term given to fetus born with clinical features of rickets, but those born with biochemical evidence of rickets without obvious clinical features still can be considered occult congenital rickets. Some of the affected babies with this disease have the intrauterine rachitic environment, but a calcium trans-placental pump prevents the fetus from having clinical features of rickets. They may present with hypocalcemia few days after birth or later with more florid features of rickets. Congenital rickets cases born with florid features reported over the last 40 years are few and can be divided into two groups...
September 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27181411/neonatal-seizures-induced-by-pentylenetetrazol-or-kainic-acid-disrupt-primary-cilia-growth-on-developing-mouse-cortical-neurons
#19
Alexander K Parker, Megan M Le, Tyler S Smith, Lan B Hoang-Minh, Eric W Atkinson, George Ugartemendia, Susan Semple-Rowland, Jason E Coleman, Matthew R Sarkisian
Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood. Newborn, post-migratory cortical neurons sprout ciliary buds (procilia) that mature into primary cilia. Disruption of the growth or signaling capabilities of these cilia has been linked to atypical neurite outgrowth from neurons and abnormalities in neuronal circuitry. Here, we tested the hypothesis that generalized seizures induced by pentylenetetrazol (PTZ) or kainic acid (KA) during early postnatal development impair neuronal and/or glial ciliogenesis...
August 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27121907/midwife-led-continuity-models-versus-other-models-of-care-for-childbearing-women
#20
REVIEW
Jane Sandall, Hora Soltani, Simon Gates, Andrew Shennan, Declan Devane
BACKGROUND: Midwives are primary providers of care for childbearing women around the world. However, there is a lack of synthesised information to establish whether there are differences in morbidity and mortality, effectiveness and psychosocial outcomes between midwife-led continuity models and other models of care. OBJECTIVES: To compare midwife-led continuity models of care with other models of care for childbearing women and their infants. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (25 January 2016) and reference lists of retrieved studies...
April 28, 2016: Cochrane Database of Systematic Reviews
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