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https://www.readbyqxmd.com/read/27759801/unusual-motor-and-non-motor-symptoms-and-signs-in-the-early-stage-of-parkinson-s-disease
#1
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27613712/pathophysiology-underlying-drooling-in-parkinson-s-disease-oropharyngeal-bradykinesia
#2
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27526039/progressive-supranuclear-palsy-and-corticobasal-degeneration-pathophysiology-and-treatment-options
#3
REVIEW
Ruth Lamb, Jonathan D Rohrer, Andrew J Lees, Huw R Morris
There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms. The use of most pharmacological treatment options are based on experience in other disorders or from non-randomized historical controls, case series, or expert opinion. Levodopa may provide some improvement in symptoms of Parkinsonism (specifically bradykinesia and rigidity) in PSP and CBD; however, evidence is conflicting and where present, benefits are often negligible and short lived...
September 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27514242/botulinum-toxin-use-in-refractory-pain-and-other-symptoms-in-parkinsonism
#4
Veronica A Bruno, Susan H Fox, Deborah Mancini, Janis M Miyasaki
BACKGROUND: Parkinson's disease (PD) and other parkinsonian syndromes are chronic, progressive neurodegenerative diseases. With advancing disease, both motor and non-motor symptoms represent a considerable burden and symptom relief and quality of life improvement become the main goal of treatment. Botulinum toxins (BTX) are an effective treatment modality for many neurological conditions. METHODS: To understand the potential usefulness of BTX in this population, we performed a retrospective chart review of all patients with a clinical diagnosis of idiopathic PD and atypical parkinsonism who received treatment with BTX injections in our center from 1995 to 2014 for a variety of symptoms...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27433087/gut-dysfunction-in-parkinson-s-disease
#5
REVIEW
Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27258695/assessment-of-nonmotor-fluctuations-using-a-diary-in-advanced-parkinson-s-disease
#6
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Since previous studies aimed to study nonmotor symptom (NMS) fluctuations in direct conjunction with motor oscillations, there are no data available on the temporal context of NMS fluctuations and motor oscillations in advanced Parkinson's disease (PD). OBJECTIVE: To evaluate circadian patterns and temporal connections of NMS and motor fluctuations in PD. METHODS: 15 controls, 17 non-fluctuating and 15 fluctuating PD patients completed two diaries by rating 4 key psychiatric (anxiety, depressive mood, inner restlessness, concentration/attention deficits), fatigue and 4 autonomic NMS (excessive sweating, sialorrhea, bladder urgency, dizziness) absent or present and motor function (Off, On with/without dyskinesia, and asleep) for every hour for 5 consecutive days...
May 31, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27114092/does-botulinum-neurotoxin-type-a-treatment-for-sialorrhea-change-oral-health
#7
Janne Tiigimäe-Saar, Pille Taba, Tiia Tamme
OBJECTIVES: Botulinum neurotoxin type A (BNT-A) intrasalivary gland injections in patients with neurological disorders have been known to effectively treat hypersalivation. However, oral health can be compromised with increasing the dose. The aim of this study was to find out the therapeutic effect of low-dose, ultrasonography-controlled BNT-A injections into the bilateral parotid and submandibular glands on oral health in the treatment of sialorrhea. MATERIAL AND METHODS: Twenty patients diagnosed with Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and other neurological disorders, including stroke or birth trauma, received BNT-A injections with salivary tests before and 1 month after the injections...
April 26, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26977920/-hypersalivation-in-parkinson-s-disease-causes-and-treatment-options
#8
Z A Zalyalova
In average 50% of patients with Parkinson's disease complain on hypersalivation, subclinical sialorrhea can be objected in 90% of them by different methods. Hypersalivation causes negative implications for the patients for themselves as well as for the caregivers. Currently there are 3 main mechanisms of sialorrhea in Parkinson's disease are considered: saliva hypersecretion, inability of saliva retention in the oral cavity (hypomimia, involuntary mouth opening, declining posture or drooping head), salivary clearance deterioration (lingual bradykinesia, oropharyngeal dysphagia, upper esophageal sphincter dysfunction)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26943467/spontaneous-swallowing-during-all-night-sleep-in-patients-with-parkinson-disease-in-comparison-with-healthy-control-subjects
#9
Irem Fatma Uludag, Bedile Irem Tiftikcioglu, Cumhur Ertekin
STUDY OBJECTIVES: Spontaneous saliva swallows (SS) appear especially during sleep. The rate of SS was rarely investigated in all-night sleep in patients with Parkinson disease (PD). Dysphagia is a frequent symptom in PD, but the rate of SS was never studied with an all-night sleep electroencephalogram (EEG). METHODS: A total of 21 patients with PD and 18 age-matched healthy controls were included in the study. Frequencies of SS and coughing were studied in all-night sleep recordings of patients with PD and controls...
April 1, 2016: Sleep
https://www.readbyqxmd.com/read/26866492/botulinum-toxin-treatment-of-autonomic-disorders-focal-hyperhidrosis-and-sialorrhea
#10
Christine Hosp, Markus K Naumann, Henning Hamm
Primary focal hyperhidrosis is a common autonomic disorder that significantly impacts quality of life. It is characterized by excessive sweating confined to circumscribed areas, such as the axillae, palms, soles, and face. Less frequent types of focal hyperhidrosis secondary to underlying causes include gustatory sweating in Frey's syndrome and compensatory sweating in Ross' syndrome and after sympathectomy. Approval of onabotulinumtoxinA for severe primary axillary hyperhidrosis in 2004 has revolutionized the treatment of this indication...
February 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/26349167/gastrointestinal-complications-in-newly-diagnosed-parkinson-s-disease-a-case-control-study
#11
L F Owolabi, A A Samaila, T Sunmonu
BACKGROUND AND AIM: In spite of the overwhelming emphasis on motor symptoms in Parkinson's disease(PD), a number of studies have revealed that the non-motor symptoms including gastrointestinal, psychiatric and sleep symptoms have a greater influence on the quality of life of many patients. This study aimed to determine the frequencies of gastrointestinal symptoms in PD patients in comparison to healthy controls and to evaluate the relationship between these GI symptoms and severity of PD...
October 2014: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
https://www.readbyqxmd.com/read/26327120/botulinum-toxin-a-and-b-in-sialorrhea-long-term-data-and-literature-overview
#12
REVIEW
Martina Petracca, Arianna Guidubaldi, Lucia Ricciardi, Tàmara Ialongo, Alessandra Del Grande, Delia Mulas, Enrico Di Stasio, Anna Rita Bentivoglio
INTRODUCTION AND OBJECTIVES: In recent years, Botulinum Toxin has been shown to be efficacious and safe in the treatment of sialorrhea, but scanty data are available on its long term use. The aim of this study was to investigate adverse events, discriminate differences in safety, and evaluate the efficacy of long-term use of both abobotulinumtoxinA and rimabotulinumtoxinB ultrasound-guided injections for sialorrhea in a retrospective trial. Moreover we review the literature on this topic...
December 1, 2015: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/26152655/the-role-of-radiation-therapy-in-the-management-of-sialorrhea-a-systematic-review
#13
REVIEW
Nathan M Hawkey, Nicholas G Zaorsky, Thomas J Galloway
PURPOSE: Up to 80% of patients with Parkinson disease and 30% of patients with amyotrophic lateral sclerosis (ALS) suffer from sialorrhea. Patients who fail medical and surgical therapy should be considered for external beam radiation therapy (EBRT). In this study, we conduct a systematic review to determine the dose and techniques used that result in greatest efficacy and lowest toxicity for the administration of EBRT in patients with Parkinson disease or ALS-associated sialorrhea. METHODS AND MATERIALS: This review included 216 patients from four prospective and six retrospective studies published from 1998 to 2014, with ALS or Parkinson disease who were treated with electron or photon EBRT for sialorrhea...
January 2016: Laryngoscope
https://www.readbyqxmd.com/read/25896289/diurnal-drooling-in-chinese-patients-with-parkinson-s-disease
#14
Ruwei Ou, Xiaoyan Guo, Qianqian Wei, Bei Cao, Jing Yang, Wei Song, Ke Chen, Bi Zhao, Xueping Chen, Huifang Shang
OBJECTIVE: The aim of this study is to explore the prevalence and clinical correlates of diurnal drooling in Chinese patients with Parkinson's disease (PD). METHODS: A cross-sectional analysis of 518 Chinese patients with PD was conducted. Each subject was categorized as a diurnal "drooler" or a "non-drooler" using the Non-Motor Symptoms Scale (NMSS). RESULTS: One hundred and twenty-one (23.4%) patients exhibited diurnal drooling. Diurnal drooling was reported more frequently in male and late-onset PD patients (p<0...
2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/25832720/design-and-development-of-a-novel-supportive-care-product-for-the-treatment-of-sialorrhea-in-parkinson-s-disease
#15
REVIEW
Neal M Farber, Santiago Perez-Lloret, Elkan R Gamzu
Sialorrhea or excessive drooling is a significant medical issue in Parkinson's disease (PD) and neurodegenerative disorders, although it is often underreported by patients. Sialorrhea affects a large proportion of PD patients, ranging up to 78% in advanced stages, with many PD patients considering drooling as their worst non-motor symptom. Sialorrhea affects up to a million patients with diverse neurological impairments, including cerebral palsy, amyotrophic lateral sclerosis (ALS), Huntington's, survivors of stroke and severe traumatic brain injury...
2015: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25726518/characterization-of-gastrointestinal-disorders-in-patients-with-parkinsonian-syndromes
#16
MULTICENTER STUDY
Hyeyoung Park, Jee Young Lee, Cheol Min Shin, Jong-Min Kim, Tae Jeong Kim, Ji Won Kim
OBJECTIVES: This study was aimed to investigate gastrointestinal (GI) dysfunction in patients with Parkinson's disease (PD) compared with those in patients with other parkinsonian disorders, and to characterize parkinsonian motor and non-motor correlates for GI dysfunction. METHODS: Consecutive patients with PD, atypical parkinsonism (P-plus) and vascular parkinsonism (VP) were enrolled in this multicenter systematic survey. Data for weight loss, appetite loss, sialorrhea, dysphagia, gastroesophageal reflux disease (GERD) and constipation were simultaneously collected using symptom-specific, structured questionnaires...
May 2015: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/25685594/disorders-of-the-oral-cavity-in-parkinson-s-disease-and-parkinsonian-syndromes
#17
REVIEW
Yair Zlotnik, Yacov Balash, Amos D Korczyn, Nir Giladi, Tanya Gurevich
Awareness of nonmotor symptoms of Parkinson's disease is growing during the last decade. Among these, oral cavity disorders are, although prevalent, often neglected by the patients, their caregivers, and physicians. Some of these disorders include increased prevalence of caries and periodontal disease, sialorrhea and drooling, xerostomia, orofacial pain, bruxism, and taste impairment. Though many of these disorders are not fully understood yet and relatively few controlled trials have been published regarding their treatment, physicians should be aware of the body of evidence that does exist on these topics...
2015: Parkinson's Disease
https://www.readbyqxmd.com/read/25537930/prevalence-and-clinical-correlates-of-drooling-in-parkinson-disease-a-study-on-518-chinese-patients
#18
Ruwei Ou, Xiaoyan Guo, Qianqian Wei, Bei Cao, Jing Yang, Wei Song, Na Shao, Bi Zhao, Xueping Chen, Huifang Shang
BACKGROUND: The prevalence and clinical correlates of drooling in Chinese patients with Parkinson disease (PD) are unknown. METHODS: A cross-sectional analysis of 518 Chinese patients with PD was conducted. Assessments included Unified PD Rating Scale (UPDRS), Non-Motor Symptoms Scale (NMSS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), PD Questionnaire-39 (PDQ-39), Frontal assessment battery (FAB) and Montreal Cognitive Assessment (MoCA). RESULTS: Two hundred and seventy-three PD patients (52...
March 2015: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/25407133/an-update-on-the-use-of-botulinum-toxin-therapy-in-parkinson-s-disease
#19
REVIEW
Reversa Mills, Laxman Bahroo, Fernando Pagan
Botulinum toxin (BoNT) has gained widespread use in a variety of neurological conditions. Parkinson's disease is a complex neurodegenerative disorder manifested by motor and non-motor symptoms that can cause significant disability. BoNT has been used to effectively treat a variety of symptoms related to Parkinson's disease. This review will examine the current therapeutic indications of BoNT use in the following disorders related to Parkinson's disease: cervical dystonia, blepharospasm and lid apraxia, focal hand dystonia, foot dystonia, laryngeal dystonia, oromandibular dystonia, camptocormia, hand and jaw tremor, sialorrhea, hyperhidrosis, dysphagia, constipation, and overactive bladder...
January 2015: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/25238916/the-use-of-botulinum-toxin-in-the-treatment-of-sialorrhea-in-parkinsonian-disorders
#20
María T Gómez-Caravaca, María T Cáceres-Redondo, Ismael Huertas-Fernández, Laura Vargas-González, Fátima Carrillo, Manuel Carballo, Pablo Mir
Drooling is a common symptom in parkinsonian disorders. Our aim was to assess the safety and effect of botulinum toxin when applied to parotid glands without ultrasound guidance for sialorrhea in parkinsonian disorders in a retrospective study with a long-term follow-up. We evaluated 53 patients (64.2% male and 35.8% female) with a mean age of 70.18 ± 9.25 years who were treated in our centre between 2007 and 2013. We analysed the mean dose, latency, effect duration, response and adverse effects of treating sialorrhea by injecting botulinum toxin type A (Botox) into the parotid glands without ultrasound guidance...
February 2015: Neurological Sciences
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