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https://www.readbyqxmd.com/read/29469716/associated-conditions-in-patients-with-multiple-dermatofibromas-case-reports-and-literature-review
#1
Surget V Beatrous, Ryan R Riahi, Stratton B Grisoli, Philip R Cohen
Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Nine dermatofibromas developed in a woman with hypothyroidism, optic neuritis, and Arnold Chiari I malformation. Five dermatofibromas developed in a woman with breast cancer who had received several systemic antineoplastic therapies...
September 22, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468424/full-depth-measurement-of-tenofovir-transport-in-rectal-mucosa-using-confocal-raman-spectroscopy-and-optical-coherence-tomography
#2
Aubrey L Presnell, Oranat Chuchuen, Morgan G Simons, Jason R Maher, David F Katz
The prophylactic activity of antiretroviral drugs applied as microbicides against sexually transmitted HIV is dependent upon their concentrations in infectable host cells. Within mucosal sites of infection (e.g., vaginal and rectal mucosa), those cells exist primarily in the stromal layer of the tissue. Traditional pharmacokinetic studies of these drugs have been challenged by poor temporal and spatial specificity. Newer techniques to measure drug concentrations, involving Raman spectroscopy, have been limited by laser penetration depth into tissue...
February 21, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29466918/multiple-sclerosis-and-hiv-a-case-of-multiple-sclerosis-immune-reconstitution-inflammatory-syndrome-associated-with-antiretroviral-therapy-initiation
#3
Pria Anand, Deanna Saylor
Studies have suggested that the incidence of multiple sclerosis (MS) in HIV-infected (HIV+) patients is lower than that of the general population. Here, we present a case of MS in an HIV+ patient with a relatively suppressed CD4 cell count who developed clinical and radiographic disease worsening in the setting of antiretroviral therapy (ART) initiation. A 47-year-old HIV+ woman (CD4 cell count 216 cells/µl) presented with decreased vision in her right eye. Magnetic resonance imaging (MRI) revealed optic nerve enhancement and open ring-enhancing lesions in the brain concerning for demyelinating disease...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29445945/spectral-domain-optical-coherence-tomography-and-fundus-autofluorescence-findings-in-cytomegalovirus-retinitis-in-hiv-infected-patients
#4
Shigeko Yashiro, Takeshi Nishijima, Yuuka Yamamoto, Yumi Sekine, Natsuyo Yoshida-Hata, Tomohiro Iida, Shinichi Oka
PURPOSE: To assess the usefulness of spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) findings in cytomegalovirus (CMV) retinitis. STUDY DESIGN: Observational case series. METHODS: Thirteen eyes of 11 human immunodeficiency virus (HIV)-positive patients with CMV retinitis underwent full ophthalmologic examinations, SD-OCT, and 4 eyes of 4 patients underwent FAF. FAF images included short-wavelength autofluorescence (SW-AF) and near-infrared autofluorescence (IR-AF)...
February 14, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29434099/a-thioflavin-t-induced-g-quadruplex-fluorescent-biosensor-for-target-dna-detection
#5
Xiao Fang Zhang, Hong Mei Xu, Lei Han, Nian Bing Li, Hong Qun Luo
The detection of disease-related DNA is of great significance for early and accurate diagnosis and therapy. In this work, we successfully achieved the sensitive detection of target DNA based on a thioflavin T (ThT)-induced G-quadruplex fluorescent biosensor. ThT, a water-soluble fluorescent dye, can induce G-rich sequences to form G-quadruplexes and obtain an obviously enhanced fluorescence. In this work, it was employed to construct a biosensor for the detection of HIV. When the target HIV existed, the hairpin DNA probes would be opened in succession and release the completely exposed G-rich sequence to combine with ThT...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29394463/primary-orbital-melanoma-treated-with-orbital-exenteration-and-postoperative-radiotherapy-a-case-report-and-review-of-the-literature
#6
Christopher P Haskins, Sommer Nurkic, Kristianna M Fredenburg, Peter T Dziegielewski, William M Mendenhall
BACKGROUND: We report on a patient with human immunodeficiency virus (HIV)-positive disease with a primary orbital melanoma treated with surgery and adjuvant radiation. METHODS: A 53-year-old woman with HIV-positive disease presented with left-sided progressive ipsilateral vision loss and proptosis. An MRI scan revealed a mass-enhancing lesion measuring 2.1 × 2.6 × 2.5 cm abutting the optic nerve. The patient underwent left orbital exenteration with temporalis flap reconstruction, pathology revealing malignant melanoma, stage T1N0M0...
February 2, 2018: Head & Neck
https://www.readbyqxmd.com/read/29363681/performance-of-point-of-care-diagnosis-of-aids-label-free-one-step-immunoassay-vs-lateral-flow-assay
#7
J-H Kwon, H-T Kim, S J Sim, Y J Cha, J Lee
The objective of this study is to develop an accurate, rapid, simple, and label-free assay technology that enables point-of-care diagnosis of AIDS. For this, 3-dimensional (3D) probes to sensitively detect anti-HIV antibodies were designed and synthesized by genetically presenting a HIV antigen (gp41) on the surface of engineered human ferritin nanoparticles. The 3D probes also present multi-copies of the hexa-histidine peptide (H6) on their surface to chemisorb gold ions (Au3+), which is essential for the generation and self-enhancement of assay signals...
January 24, 2018: Analyst
https://www.readbyqxmd.com/read/29332035/an-aspartyl-cathepsin-targeted-pet-agent-application-in-an-alzheimer-s-disease-mouse-model
#8
Jonatan A Snir, Mojmir Suchy, Geron A Bindseil, Michael Kovacs, Blaine A Chronik, Robert H E Hudson, Stephen H Pasternak, Robert Bartha
BACKGROUND: Early detection of Alzheimer's disease (AD) pathology is a serious challenge for both diagnosis and clinical trials. The aspartyl protease, Cathepsin D (CatD), is overexpressed in AD and could be a biomarker of disease. We have previously designed a unique contrast agent (CA) for dual-optical and magnetic resonance imaging of the activity of the CatD class of enzymes. OBJECTIVE: To compare the uptake and retention of a novel, more sensitive, and clinically-translatable 68Ga PET tracer targeting CatD activity in 5XFAD mice and non-Tg littermates...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29279653/clinical-profile-and-outcomes-of-optic-neuritis-in-an-hiv-prevalent-urban-community-in-south-africa
#9
Hamzah Mustak, Colin Cook
PURPOSE: To determine the clinical profile, causes and response to corticosteroid therapy in patients admitted and treated for optic neuritis at a tertiary hospital in Cape Town, South Africa. METHODS: A retrospective case review of 117 patients with optic neuritis between January 2002 and December 2012. Demographic information, clinical presentation, course of illness, investigations performed and visual outcomes at discharge and at three month follow up were collected for analysis...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260044/isolated-presumed-optic-nerve-gumma-a-rare-presentation-of-neurosyphilis
#10
Nailyn Rasool, James A Stefater, Dean Eliott, Dean M Cestari
Purpose: The incidence of syphilitic infections continues to rise and represents a major public health concern, particularly in patients co-infected with human immunodeficiency virus (HIV). The infection has a multitude of clinical presentations and is often referred to as the 'great imitator.' We present a rare case of an isolated presumed syphilitic optic nerve gumma and characterize it using newer imaging modalities. Observations: A 36-year-old HIV-positive man, compliant with treatment, presented with a five day history of decreased vision in the left eye...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29223959/performance-and-operational-characteristics-of-point-of-care-tests-for-the-diagnosis-of-urogenital-gonococcal-infections
#11
REVIEW
Rebecca J Guy, Louise M Causer, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Anna M Azzini, Rosanna W Peeling
BACKGROUND: In 2012, there was an estimated 78 million new cases of gonorrhoea globally. Untreated infection may lead to reproductive and neonatal morbidity and facilitate HIV transmission. Diagnosis and treatment are a priority for control and prevention, yet use of point-of-care tests (POCTs) for Neisseria gonorrhoeae (NG) is limited. OBJECTIVES: To review the performance and operational characteristics of NG POCTs for diagnosis of urogenital gonorrhoea. METHODS: We compiled and synthesised findings from two separate systematic reviews which included evaluations published until August 2015...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29204904/the-functionality-of-african-specific-variants-in-the-tgfb1-regulatory-region-and-their-potential-role-in-hivan
#12
M Nel, J-M Buys, F C J Botha, N Wearne, S Prince, J M Heckmann
BACKGROUND: Transcription of transforming growth factor beta-1 (TGF-β1) is regulated by a polymorphic promoter region containing African-specific single nucleotide polymorphisms (SNPs). Some of these SNPs have higher frequencies among Southern Africans compared to other African populations and their functionality has only been partially studied. Due to the high prevalence of HIV-associated nephropathy (HIVAN) in Africans we hypothesized that functional African TGFB1-promoter SNPs may contribute to HIVAN pathogenesis...
December 4, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29195504/blinded-by-zika-a-missed-hiv-diagnosis-that-resulted-in-optic-neuropathy-and-blindness-a-case-report
#13
Tiffany Hirschel, Heimo Steffen, Victor Pecoul, Alexandra Calmy
BACKGROUND: Typical symptoms of an acute human immunodeficiency virus (HIV) infections like fever and rash are not specific and can be caused by a multitude of other pathogens, such as Zika or rickettsiosis. Up to 30% of primary HIV infection do not present with the typical flu-like symptoms and thus represent a diagnostic challenge. In this report, we describe a rare case of optic neuropathy as the initial presentation of primary HIV infection, which resulted in irreversible blindness...
December 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29183044/inflammatory-and-neuronal-biomarkers-associated-with-retinal-thinning-in-pediatric-hiv
#14
Charlotte Blokhuis, Susanne Doeleman, Sophie Cohen, Nazli Demirkaya, Henriëtte J Scherpbier, Neeltje A Kootstra, Jens Kuhle, Charlotte E Teunissen, Frank D Verbraak, Dasja Pajkrt
Purpose: The pathophysiology of neuroretinal thinning in children with human immunodeficiency virus (HIV) is poorly understood. The current study aimed to assess whether neuroretinal thinning in clinically stable perinatally HIV-infected children was associated with biomarkers of immune activation, inflammation, and neuronal damage. Methods: Inflammation-associated and neuronal damage markers were measured in blood and cerebrospinal fluid (CSF) of HIV-infected children aged 8 to 18 years...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29176535/spontaneous-improvement-of-syphilis-chorioretinitis-case-report-and-review-of-the-literature
#15
Ahmad M Sidiqi, Eduardo V Navajas
PURPOSE: To describe a case of spontaneous improvement of syphilis chorioretinitis and review the literature. METHODS: Case report and literature review of cases with untreated syphilis chorioretinitis. RESULTS: A 58-year-old man presented to the emergency department with counting fingers vision, normal fundus, and disruption of the outer retinal layers on optical coherence tomography of the right eye. Examination by a retina specialist 3 weeks later revealed visual acuity of 20/50 and partial restoration of outer retinal layers on optical coherence tomography...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29141704/human-competence-to-transmit-leishmania-infantum-to-lutzomyia-longipalpis-and-the-influence-of-human-immunodeficiency-virus-infection
#16
Gabriel Reis Ferreira, José Carlos Castelo Branco Ribeiro, Antônio Meneses Filho, Teresinha de Jesus Cardoso Farias Pereira, Daniela Moura Parente, Humberto Feitosa Pereira, Jailthon Carlos da Silva, Danielle Alves Zacarias, Letiano Vieira da Silva, Symonara Karina Medeiros Faustino, Walfrido Salmito Almeida Neto, Dorcas Lamounier Costa, Ivete Lopes de Mendonça, Carlos Henrique Nery Costa
Visceral leishmaniasis (VL) caused by Leishmania infantum is a lethal disease transmitted by sand flies. Although, considered a zoonosis with dogs held as the main reservoirs, humans are also sources of infection. Therefore, control policies currently focused on dog culling may need to consider that VL and human immunodeficiency virus (HIV)/VL patients may also be infectious, contributing to transmission. Reservoir competence of patients with VL without and with HIV infection and of persons asymptomatically infected with Leishmania was assessed by xenodiagnosis with the vector Lutzomyia longipalpis...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29069031/clinical-manifestations-and-treatment-outcomes-of-syphilitic-uveitis-in-hiv-negative-patients-in-china-a-retrospective-case-study
#17
Jiang Zhu, Yuan Jiang, Yewen Shi, Bo Zheng, Zhiguo Xu, Wei Jia
Syphilitic chorioretinitis should be included in differential diagnosis of any form of ocular inflammation. A significantly higher proportion of human immunodeficiency virus (HIV)-positive patients with ocular syphilis as compared to HIV-negative cases have been reported in published studies. However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed. We report a series of cases of ocular syphilis and describe the clinical manifestations and treatment outcomes of syphilitic chorioretinitis in HIV-negative patients in China...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29040166/measurement-of-retinal-vessels-as-a-biomarker-of-cerebrovascular-ageing-in-older-hiv-positive-men-compared-to-controls
#18
Lewis Haddow, Rosanna Laverick, Irene Leung, Frank Post, Jaime Vera, Richard Gilson, Ian Williams, Marta Boffito, Caroline Sabin, Alan Winston, Tunde Peto
BACKGROUND: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease (SVD), in HIV positive men aged 50 years and above with similarly-aged HIV negative men and younger HIV positive men. METHODS: We recruited white, non-diabetic men to a cross-sectional substudy of a larger cohort including three demographically-matched groups. Optic disc centred 45° colour fundus photographs were used to calculate central retinal arterial and venous calibre and the arterial-venous ratio (AVR)...
October 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29016527/acute-macular-neuroretinopathy-and-peripheral-retinal-vascular-abnormalities-in-a-patient-born-hiv-seropositive
#19
Chiara Giuffrè, Alessandro Rabiolo, Eleonora Corbelli, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To describe the case of a born HIV seropositive woman who developed outer retinal alterations secondary to vascular abnormalities in the perimacular region and in the periphery of both eyes. METHODS: Case report. RESULTS: A 21-year-old woman born HIV seropositive was referred for a routinary visit. Her best-corrected visual acuity was 20/20 in both eyes, and during the visit, only mild superotemporal metamorphopsia in the left eye was reported...
October 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28961280/label-free-analysis-of-tenofovir-delivery-to-vaginal-tissue-using-co-registered-confocal-raman-spectroscopy-and-optical-coherence-tomography
#20
Oranat Chuchuen, Jason R Maher, Marcus H Henderson, Michael Desoto, Lisa C Rohan, Adam Wax, David F Katz
Vaginally applied microbicide products offer a female-controlled strategy for preventing sexual transmission of HIV. Microbicide transport processes are central to their functioning, and there is a clear need for a better understanding of them. To contribute to that end, we developed an assay to analyze mass transport rates of microbicide molecules within the epithelial and stromal layers of polarized vaginal mucosal tissue during contact with a gel vehicle. The assay utilizes a new diffusion chamber mounted in a custom instrument that combines confocal Raman spectroscopy and optical coherence tomography...
2017: PloS One
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