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https://www.readbyqxmd.com/read/28418652/design-and-development-of-highly-potent-hiv-1-protease-inhibitors-with-a-crown-like-oxotricyclic-core-as-the-p2-ligand-to-combat-multidrug-resistant-hiv-variants
#1
Arun K Ghosh, Kalapala Venkateswara Rao, Prasanth R Nyalapatla, Heather L Osswald, Cuthbert D Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T Weber, Hiroaki Mitsuya
Design, synthesis, and evaluation of a new class of exceptionally potent HIV-1 protease inhibitors are reported. Inhibitor 5 displayed superior antiviral activity and drug-resistance profiles. In fact, this inhibitor showed several orders of magnitude improved antiviral activity over the FDA approved drug darunavir. This inhibitor incorporates an unprecedented 6-5-5 ring-fused crown-like tetrahydropyranofuran as the P2 ligand and an aminobenzothiazole as the P2' ligand with the (R)-hydroxyethylsulfonamide isostere...
April 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28418539/ophthalmic-manifestations-of-congenital-zika-syndrome-in-colombia-and-venezuela
#2
Juan B Yepez, Felipe A Murati, Michele Pettito, Carlos F Peñaranda, Jazmin de Yepez, Gladys Maestre, J Fernando Arevalo
Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. In addition, confirmation whether the public health problem in Brazil extends to other regions in South America is needed...
April 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28333858/immune-reconstitution-inflammatory-syndrome-causing-progressive-optic-nerve-edema-in-cryptococcal-meningitis
#3
Astrid C Werner, Laurel N Vuong, Thomas R Hedges, Caroline R Baumal
PURPOSE: To report an human immunodeficiency virus-positive patient undergoing therapy for cryptococcal meningitis who developed progressive optic disc edema that was steroid responsive. METHODS: Observational case report. RESULTS: One month after commencing antifungal treatment for cryptococcal meningitis, the patient developed bilateral, progressive, recurrent optic disc edema with subretinal fluid that coincided with initiation of highly active antiretroviral therapy and recovery of CD4 cell counts...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28318310/comparison-of-maxim-and-sedia-limiting-antigen-assay-performance-for-measuring-hiv-incidence
#4
Katherine E Schlusser, Jacob Konikoff, Allison R Kirkpatrick, Charles Morrison, Tsungai Chipato, Pai-Lien Chen, Marshall Munjoma, Susan H Eshleman, Oliver Laeyendecker
Accurate methods for cross-sectional incidence estimation are needed for HIV prevention research. The Limiting Antigen Avidity (LAg-Avidity) assay has been marketed by two vendors, Maxim Biomedical and Sedia BioSciences Corporation. Performance differences between the two versions of the assay are unknown. We tested a total 1,410 treatment-naive samples with both versions of the assay. The samples came from 176 seroconverters from the Zimbabwe Hormonal Contraception and HIV Study. The correlation between the two versions of the assay was 0...
March 20, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28282092/nir-emitting-and-photo-thermal-active-nanogold-as-mitochondria-specific-probes
#5
Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil
We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells...
March 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28253349/single-particle-maximum-likelihood-reconstruction-from-superresolution-microscopy-images
#6
Timothée Verdier, Julia Gunzenhauser, Suliana Manley, Martin Castelnovo
Point localization superresolution microscopy enables fluorescently tagged molecules to be imaged beyond the optical diffraction limit, reaching single molecule localization precisions down to a few nanometers. For small objects whose sizes are few times this precision, localization uncertainty prevents the straightforward extraction of a structural model from the reconstructed images. We demonstrate in the present work that this limitation can be overcome at the single particle level, requiring no particle averaging, by using a maximum likelihood reconstruction (MLR) method perfectly suited to the stochastic nature of such superresolution imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28213534/quantitative-correlation-between-infectivity-and-gp120-density-on-hiv-1-virions-revealed-by-optical-trapping-virometry
#7
Michael C DeSantis, Jin H Kim, Hanna Song, Per Johan Klasse, Wei Cheng
No abstract text is available yet for this article.
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28199410/ultrasensitive-detection-of-hiv-1-p24-antigen-by-a-hybrid-nanomechanical-optoplasmonic-platform-with-potential-for-detecting-hiv-1-at-first-week-after-infection
#8
Priscila M Kosaka, Valerio Pini, Montserrat Calleja, Javier Tamayo
Early detection of HIV infection is the best way to prevent spread of the disease and to improve the efficiency of the antiretroviral therapy. Nucleic acid amplification tests (NAAT) have become the gold-standard for detecting low-concentrations of the virus in blood. However, these methods are technically demanding and cost-prohibitive in developing countries. Immunoassays are more affordable and can be more easily adapted for point-of-care diagnosis. However, the sensitivity so far of these methods has been too low...
2017: PloS One
https://www.readbyqxmd.com/read/28101049/tuberculous-subretinal-abscess-in-a-non-hiv-patient-with-miliary-tuberculosis
#9
Eugenia Paez Soria, Paula Magnano, Ariel Schlaen, Paula Luvini, Gisela Arevalo Calderon, Mauricio Martinez Cartier, Pablo Chiaradía, Cristóbal Couto
This case report describes the features of a tuberculous subretinal abscess in a non-HIV patient. It includes the characterization of the lesion with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence examination. SD-OCT and autofluorescence imaging showed external retinal involvement during development of the tuberculous subretinal abscess. Patients with tuberculous lesions need a multidisciplinary approach, since the disease may involve any part of the body. In this case in particular, incidental findings at computed tomography scan led to the detection of this rare ocular manifestation of tuberculous disease...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28074347/pattern-and-motion-related-visual-evoked-potentials-in-hiv-infected-adults
#10
Jana Szanyi, Jan Kremlacek, Zuzana Kubova, Miroslav Kuba, Pavel Gebousky, Jaroslav Kapla, Juraj Szanyi, Frantisek Vit, Jana Langrova
PURPOSE: The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs). METHODS: The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts ≥230 × 10(6) cells/L of blood. RESULTS: Nine out of 20 patients displayed VEP abnormalities...
February 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28019008/enantiomeric-resolution-stereochemical-assignment-and-toxicity-evaluation-of-tpa-enantiomers
#11
Yulang Chi, Zhijun Wu, Yi Zhong, Sijun Dong
Tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid (TPA) is a critical intermediate in the synthesis of HIV protease inhibitors. A simple and efficient method for the separation and determination of TPA enantiomers was developed. The TPA was separated into its enantiomers with an enantiomeric purity of 99% using an HPLC system equipped with a Chiralpak OD-H column. Semi-preparative HPLC enantioseparations were carried out for further enrichment of the enantiomers. The validity of this method was evaluated on the basis of its precision, accuracy, linearity and recovery...
December 26, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27999698/necrotizing-retinitis-secondary-to-congenital-cytomegalovirus-infection-associated-with-severe-combined-immunodeficiency
#12
Pehmen Yasin Ozcan, Hasan Tolga Celik, Kenan Sonmez, Melda Celik
A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insufficiency. In retinal examination, peripheric retinal white-black color areas that correspond to necrotizing retinitis, moderate vitritis, macular and optic nerve head involvement, vascular leakage, and sheathing indicating perivasculitis were revealed. Despite the fact that CMV specific IgM was undetectable, CMV DNA with high viral load was found in his blood sample by means of real-time polymerase chain reaction assay...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27956326/syphilitic-posterior-placoid-chorioretinitis-as-initial-presentation-of-early-neurosyphilis
#13
F E Molina-Sócola, F López-Herrero, A Medina-Tapia, T Rueda-Rueda, M Contreras-Díaz, J L Sánchez-Vicente
CASE REPORT: A 36 year-old male with a recent HIV diagnosis, presented with loss of vision of his left eye. Ophthalmoscopy revealed a unilateral yellowish placoid lesion in the macula. After fluorescein angiography, optical coherence tomography, optical coherence tomography angiography, syphilis serology, and cerebrospinal fluid results, he was diagnosed with neurosyphilis and syphilitic posterior placoid chorioretinitis. DISCUSSION: Acute syphilitic posterior placoid chorioretinitis is a rare ocular manifestation of syphilis...
December 7, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27928388/syphilitic-optic-neuropathy-re-emerging-cases-over-a-2-year-period
#14
Supanut Apinyawasisuk, Anuchit Poonyathalang, Pisit Preechawat, Kavin Vanikieti
We report 7 cases of syphilitic optic neuropathy during a 2-year period. All patients were newly diagnosed with human immunodeficiency virus (HIV) infection. Six cases (86%) initially presented with swollen optic disc either unilaterally or bilaterally. Blind spot enlargement was the most common type of visual field defect. Final visual acuity of at least 20/25 was achieved together with visual field improvement and resolution of swollen optic disc. Optic nerve involvement can be the first manifestation of syphilis and HIV co-infection...
April 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27908111/nuclear-quantum-effects-in-a-hiv-cancer-inhibitor-the-case-of-ellipticine
#15
Subrahmanyam Sappati, Ali Hassanali, Ralph Gebauer, Prasenjit Ghosh
Ellipticine is a natural product that is currently being actively investigated for its inhibitory cancer and HIV properties. Here we use path-integral molecular dynamics coupled with excited state calculations to characterize the role of nuclear quantum effects on the structural and electronic properties of ellipticine in water, a common biological solvent. Quantum effects collectively enhance the fluctuations of both light and heavy nuclei of the covalent and hydrogen bonds in ellipticine. In particular, for the ellipticine-water system, where the proton donor and acceptor have different proton affinities, we find that nuclear quantum effects (NQEs) strengthen both the strong and the weak H bonds...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27858357/surface-plasmon-resonance-analysis-of-heparin-binding-angiogenic-growth-factors
#16
Marco Rusnati, Antonella Bugatti
Surface plasmon resonance (SPR) is an optical technique to evaluate biomolecular interactions. Briefly, SPR measures the capacity of two molecules to bind each other by detecting reflected light from a prism-gold film interface. One of the two putative interactants (called ligand) is chemically immobilized onto the gold film. When the sensor is exposed to a sample containing the second interactant (called analyte), its binding to the immobilized ligand causes a change of the refractive index of the material above the gold surface that is monitored as a real-time graph of the response units against time, producing a real-time graph called sensorgram...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27806411/anal-chromoendoscopy-using-gastroenterological-video-endoscopes-a-new-method-to-perform-high-resolution-anoscopy-for-diagnosing-intraepithelial-neoplasia-and-anal%C3%A2-carcinoma-in-hiv-infected-patients
#17
Mark Oette, Ulrike Wieland, Marko Schünemann, Johannes Haes, Stefan Reuter, Björn Erik Ole Jensen, Abdurrahman Sagir, Herbert Pfister, Dieter Häussinger
Introduction Anal carcinoma represents an increasing problem in HIV-infected patients. Anal intraepithelial neoplasia (AIN), the precursor lesion, is currently diagnosed by high-resolution anoscopy (HRA) using optical magnification derived from gynecological colposcopy. This prospective study evaluates anal chromoendoscopy (ACE) using standard gastroenterological video-endoscopes in diagnosing AIN. Methods After clinical examination, proctoscopy and surface staining with acetic acid followed by Lugol's solution, ACE was performed with a mucosectomy cap on the tip of the endoscope...
January 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27780490/evaluation-of-the-limiting-antigen-avidity-eia-lag-in-people-who-inject-drugs-in-greece
#18
G K Nikolopoulos, A Katsoulidou, M Kantzanou, C Rokka, C Tsiara, V Sypsa, D Paraskevis, M Psichogiou, S Friedman, A Hatzakis
This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected >6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons...
January 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/27753271/intravital-excitation-increases-detection-sensitivity-for-pulmonary-tuberculosis-by-whole-body-imaging-with-%C3%AE-lactamase-reporter-enzyme-fluorescence
#19
Fatemeh Nooshabadi, Hee-Jeong Yang, Yunfeng Cheng, Madeleine S Durkee, Hexin Xie, Jianghong Rao, Jeffrey D Cirillo, Kristen C Maitland
Tuberculosis is a pulmonary disease with an especially high mortality rate in immuno-compromised populations, specifically children and HIV positive individuals. The causative agent, Mycobacterium tuberculosis (Mtb), is a very slow growing and difficult organism to work with, making both diagnosis and development of effective treatments cumbersome. We utilize a fiber-optic fluorescence microendoscope integrated with a whole-body imaging system for in vivo Mtb detection. The system exploits an endogenous enzyme of Mtb (β-lactamase, or BlaC) using a BlaC-specific NIR fluorogenic substrate...
October 18, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27752180/-panuveitis-with-oral-and-genital-ulcer-misdiagnosed-as-behcet-s-disease-two-cases-report-and-literature-review
#20
Y Wang, L Yang, Z L Zhang
Here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. They were misdiagnosed with Behcet's disease at first glance. Two young males presented with acute uveitis with history of recurrent oral and genital ulcers. They initially presented with symptoms and signs resembling Behcet's disease and were treated with systemic steroids with suboptimal responses. Routine laboratory test revealed syphilis and human immunodeficiency virus (HIV) infection...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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