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https://www.readbyqxmd.com/read/29908510/role-of-drinking-water-biofilms-on-residual-chlorine-decay-and-trihalomethane-formation-an-experimental-and-modeling-study
#1
Jianeng Xu, Conghui Huang, Xiaoyang Shi, Shengkun Dong, Baoling Yuan, Thanh H Nguyen
PVC pipe loops were constructed to simulate household premise plumbing. These pipe loops were exposed to water treated by physical processes at three water treatment plants in Xiamen, China from August 2016 to June 2017. After the biofilms were allowed to develop inside the pipes, these pipes were deconstructed and exposed to organic-free chlorine solution buffered at pH 6.8 ± 0.2 for 48 h. The decay of chlorine by these biofilms was higher than by the effluent waters that were used to grow the biofilms...
June 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29908434/characterizing-within-subject-variability-in-quantified-measures-of-balance-control-a-cohort-study
#2
Lise C Worthen-Chaudhari, Scott M Monfort, Courtney Bland, Xueliang Pan, Ajit M W Chaudhari
BACKGROUND: To longitudinally assess individuals using quantified measures, we must characterize within-subject variability (WSV) of the measures. RESEARCH QUESTION: What is the natural within-subject variability (WSV) that can be expected in postural control over 3+ days? METHODS: Thirteen individuals without orthopedic or neurologic impairment (mean(SD) = 55 (9) years; 76 (18) kg; 11 females/2 males) were recruited from a community workplace and consented to participate...
June 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29908366/g-d3-ganglioside-enriched-extracellular-vesicles-stimulate-melanocyte-migration
#3
Andreia Hanada Otake, Renata de Freitas Saito, Ana Paula Marques Duarte, Alexandre Ferreira Ramos, Roger Chammas
Melanomas often accumulate gangliosides, sialic acid-containing glycosphingolipids found in the outer leaflet of plasma membranes, as disialoganglioside GD3 and its derivatives. Here, we have transfected the GD3 synthase gene (ST8Sia I) in a normal melanocyte cell line in order to evaluate changes in the biological behavior of non-transformed cells. GD3 -synthase expressing cells converted GM3 into GD3 and accumulated both GD3 and its acetylated form, 9-O-acetyl-GD3 . Melanocytes were rendered more migratory on laminin-1 surfaces...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908357/coronal-trunk-imbalance-in-idiopathic-scoliosis-does-gravity-line-localisation-confirm-the-physical-findings
#4
Thibault Hernandez, Thomas Thenard, Claudio Vergari, Leopold Robichon, Wafa Skalli, Raphaël Vialle
BACKGROUND: Adolescent idiopathic scoliosis (AIS) can require surgical procedures that have major consequences. Coronal imbalance as assessed clinically using a plumb line is a key criterion for selecting patients to surgery. Nevertheless, the reference standard for assessing postural balance of the trunk is gravity line localisation within a validated frame of reference. Recent studies have established that the gravity line can be localised after body contour reconstruction from biplanar radiographs...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29908067/effects-of-type-i-interferons-in-malaria
#5
REVIEW
Ismail Sebina, Ashraful Haque
Type I interferons are a family of cytokines with a wide range of biological activities including anti-viral and immune-regulatory functions. Here, we focus on the protozoan parasitic disease, malaria, and examine the effects of type I IFN-signalling during Plasmodium infection of humans and experimental mice. Since the 1960's, there have been many studies in this area, but a simple explanation for the role of type I IFN has not emerged. Although epidemiological data are consistent with roles for type I IFN in influencing malaria disease severity, functional proof of this remains sparse in humans...
June 16, 2018: Immunology
https://www.readbyqxmd.com/read/29907499/incidence-of-temporary-mechanical-circulatory-support-before-heart-transplantation-and-impact-on-post-transplant-outcomes
#6
David Ouyang, Gunsagar Gulati, Richard Ha, Dipanjan Banerjee
BACKGROUND: Proposed changes to the United Network for Organ Sharing heart transplant allocation protocol will prioritize patients receiving temporary mechanical circulatory support (tMCS), including extracorporeal membrane oxygenation (ECMO), percutaneous ventricular assist devices (PVADs), and intra-aortic balloon pumps (IABPs). We sought to evaluate contemporary trends in the incidence and outcomes of patients who required tMCS during the hospitalization before heart transplantation...
April 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29907353/determinants-of-skeletal-muscle-protein-turnover-following-severe-burn-trauma-in-children
#7
Ioannis Malagaris, David N Herndon, Efstathia Polychronopoulou, Victoria G Rontoyanni, Clark R Andersen, Oscar E Suman, Craig Porter, Labros S Sidossis
BACKGROUND & AIMS: Burns remain the fifth cause of non-fatal pediatric injuries globally, with muscle cachexia being a hallmark of the stress response to burns. Burn-induced muscle wasting is associated with morbidity, yet the determinants of muscle protein catabolism in response to burn trauma remains unclear. Our objective was to determine the effect of patient and injury characteristics on muscle protein kinetics in burn patients. METHODS: This retrospective, observational study was performed using protein kinetic data from pediatric patients who had severe burns (>30% of the total body surface area burned) and underwent cross-limb stable isotope infusions between 1999 and 2008 as part of prospective clinical trials...
June 4, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29905808/pharmacokinetic-modelling-of-darunavir-ritonavir-dose-reduction-800-100-to-400-100-mg-once-daily-in-a-darunavir-ritonavir-containing-regimen-in-virologically-suppressed-hiv-infected-patients-anrs-165-darulight-sub-study
#8
Minh P Lê, Marie-Laure Chaix, Sylvie Chevret, Julie Bertrand, François Raffi, Sébastien Gallien, El Mountacer Billah El Abbassi, Christine Katlama, Pierre Delobel, Yazdan Yazdanpanah, Juliette Saillard, Jean-Michel Molina, Gilles Peytavin
Background: In the ANRS 165 DARULIGHT study (NCT02384967) carried out in HIV-infected patients, the use of a darunavir/ritonavir-containing regimen with a switch to a reduced dose of darunavir maintained virological efficacy (≤50 copies/mL) for 48 weeks with a good safety profile. Objectives: To assess the total and unbound blood plasma pharmacokinetics of darunavir and associated antiretrovirals, and their penetration into semen before and after dose reduction...
June 13, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29905545/-a-comparative-evaluation-of-the-effect-of-dentures-from-various-materials-on-the-oral-cavity-s-immunological-and-redox-dependent-homeostasis
#9
Z Nakudashvili, I Mgebrishvili, I Barbakadze, T Sanikidze
The purpose of our study was a comparative analysis of the effect of dentures from various materials on the immunological and redox-dependent homeostasis of the oral cavity. We studied 60 patients with removable dentures made based on plastics Prothyl Hot, Vertex BasiQ 20 (differing by polymerization regime) and elastic thermoplastic polymer Perflex Flexi Nylon. The control group consisted of 15 volunteers with a practically healthy oral cavity, who did not use dentures. Saliva collected on an empty stomach in a glass tube without the use of a stimulator before the establishment of a denture and 3 days and 1 month after...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#10
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904917/lumichrome-inhibits-osteoclastogenesis-and-bone-resorption-through-suppressing-rankl-induced-nfat-activation-and-calcium-signaling
#11
Chuan Liu, Zhen Cao, Wen Zhang, Jennifer Tickner, Heng Qiu, Chao Wang, Kai Chen, Ziyi Wang, Renxiang Tan, Shiwu Dong, Jiake Xu
The dynamic balance between bone resorption and bone formation is crucial to maintain bone mass. Osteoclasts are key cells that perform bone resorption while osteoblasts and osteocytes function in bone formation. Osteoporosis, a bone metabolism disease characterized by bone loss and degradation of bone microstructure, occurs when osteoclastic bone resorption outstrips osteoblastic bone synthesis. The interaction between receptor activator of nuclear factor κB ligand (RANKL) and RANK on the surface of bone marrow macrophages promotes osteoclast differentiation and activation...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29904708/data-on-empirical-estimation-of-the-relationship-between-agency-costs-and-ownership-structure-in-italian-listed-companies-2002-2013
#12
Fabrizio Rossi, James R Barth, Richard J Cebula
The data presented in this article are related to the research article entitled "Do shareholder coalitions affect agency costs? Evidence from Italian-listed companies", Research in International Business and Finance , Forthcoming (Rossi et al., 2018) [1]. The study shows an empirical analysis using an extensive balanced panel dataset of 163 Italian listed companies for the period 2002-2013, which is a sample yielding 1956 firm-year observations. The sample consists primarily of manufacturing firms, but also includes some service enterprises...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904688/data-on-mass-spectrometry-based-proteomics-for-studying-the-involvement-of-cyld-in-the-ubiquitination-events-downstream-of-egfr-activation
#13
Virginia Sanchez-Quiles, Nerea Osinalde, Vyacheslav Akimov, Irina Kratchmarova, Blagoy Blagoev
The present data article corresponds to the proteomic data of the involvement of Cylindromatosis protein (CYLD) in the ubiquitination signaling initiated by EGF stimulation. CYLD tumor suppressor protein has Lys63-chain deubiquitinase activity that has been proved essential for the negative regulation of crucial signaling mechanisms, namely the NFkB pathway. Previous results have suggested the involvement of CYLD in the EGF-dependent signal transduction as well, showing its engagement within the tyrosine-phosphorylated complexes formed following the addition of the growth factor...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904418/acquired-hypophosphatemic-osteomalacia-is-easily-misdiagnosed-or-neglected-by-rheumatologists-a-report-of-9-cases
#14
Ling Li, Shu-Xia Wang, Hong-Mei Wu, Dong-Lan Luo, Guang-Fu Dong, Yuan Feng, Xiao Zhang
The aim of the present study was to assist rheumatologists in differentiating hypophosphatemic osteomalacia (HO) from mimic rheumatology diseases. Clinical data was obtained from 9 patients with acquired HO, initially misdiagnosed as mimic rheumatologic diseases. The data were retrospectively analyzed and a literature review was performed. The etiology of the cases was as follows: Adefovir dipivoxil-induced Fanconi syndrome was present in 6 of the cases, 2 were tumors and 1 case was chronic nephropathy. The chief complaint was thoracic or back pain and arthralgia, followed by progressive muscle weakness and dramatic movement limitation...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904348/berberine-regulates-treg-th17-balance-to-treat-ulcerative-colitis-through-modulating-the-gut-microbiota-in-the-colon
#15
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29904241/microbial-markers-in-colorectal-cancer-detection-and-or-prognosis
#16
REVIEW
Romain Villéger, Amélie Lopès, Julie Veziant, Johan Gagnière, Nicolas Barnich, Elisabeth Billard, Delphine Boucher, Mathilde Bonnet
Colorectal cancer (CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29903984/bolus-ingestion-of-whey-protein-immediately-post-exercise-does-not-influence-rehydration-compared-to-energy-matched-carbohydrate-ingestion
#17
Gethin H Evans, Lewis Mattin, Isabelle Ireland, William Harrison, Adora M W Yau, Victoria McIver, Tristan Pocock, Elizabeth Sheader, Lewis J James
Whey protein is a commonly ingested nutritional supplement amongst athletes and regular exercisers; however, its role in post-exercise rehydration remains unclear. Eight healthy male and female participants completed two experimental trials involving the ingestion of 35 g of whey protein (WP) or maltodextrin (MD) at the onset of a rehydration period, followed by ingestion of water to a volume equivalent to 150% of the amount of body mass lost during exercise in the heat. The gastric emptying rates of the solutions were measured using 13 C breath tests...
June 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29903912/molecular-principles-for-heparin-oligosaccharide-based-inhibition-of-neutrophil-elastase-in-cystic-fibrosis
#18
Apparao B Kummarapurugu, Daniel K Afosah, Nehru Viji Sankaranarayanan, Rahaman Navaz Gangji, Shuo Zheng, Thomas P Kennedy, Bruce K Rubin, Judith A Voynow, Umesh R Desai
Cystic fibrosis (CF)1 is a multi-factorial disease in which dysfunction of protease-antiprotease balance plays a key role. The current CF therapy relies on dornase alfa, low dose macrolide antibiotics, hypertonic saline and antibiotics, and does not address the high neutrophil elastase (NE) activity observed in the lung and sputum of CF patients. Our hypothesis is that variants of heparin, which potently inhibit NE but are not anticoagulant, would help restore the protease-antiprotease balance in CF. To realize this concept, we studied molecular principles governing the effectiveness of different heparins, especially 2-O,3-O-desulfated heparin (ODSH), in the presence of sputum components and therapeutic agents...
June 14, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29903906/parkin-negatively-regulates-the-antiviral-signaling-pathway-by-targeting-traf3-for-degradation
#19
Di Xin, Haiyan Gu, Enping Liu, Qinmiao Sun
Chronic neuroinflammation is a characteristic of Parkinson's disease (PD). Previous investigations have shown that Parkin gene mutations are related to the early-onset recessive form of PD and isolated juvenile-onset PD. Further, Parkin plays important roles in mitochondrial quality control and cytokine-induced cell death. However, whether Parkin regulates other cellular events is still largely unknown. In this study, we performed overexpression and knockout experiments, and found that Parkin negatively regulates antiviral immune responses against RNA and DNA viruses...
June 14, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29903649/cortical-activity-during-walking-and-balance-tasks-in-older-adults-and-in-people-with-parkinson-s-disease-a-structured-review
#20
REVIEW
Samuel Stuart, Rodrigo Vitorio, Rosie Morris, Douglas N Martini, Peter C Fino, Martina Mancini
An emerging body of literature has examined cortical activity during walking and balance tasks in older adults and in people with Parkinson's disease, specifically using functional near infrared spectroscopy (fNIRS) or electroencephalography (EEG). This review provides an overview of this developing area, and examines the disease-specific mechanisms underlying walking or balance deficits. Medline, PubMed, PsychInfo and Scopus databases were searched. Articles that described cortical activity during walking and balance tasks in older adults and in those with PD were screened by the reviewers...
July 2018: Maturitas
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