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https://www.readbyqxmd.com/read/28329707/dendritic-cells-display-subset-and-tissue-specific-maturation-dynamics-over-human-life
#1
Tomer Granot, Takashi Senda, Dustin J Carpenter, Nobuhide Matsuoka, Joshua Weiner, Claire L Gordon, Michelle Miron, Brahma V Kumar, Adam Griesemer, Siu-Hong Ho, Harvey Lerner, Joseph J C Thome, Thomas Connors, Boris Reizis, Donna L Farber
Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141(hi)CD13(hi)) and cDC2 (Sirp-α(+)CD1c(+)) subsets was a function of tissue site and was conserved between donors...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28329200/clinical-trends-in-surgical-minimally-invasive-and-transcatheter-aortic-valve-replacement%C3%A2
#2
Tom C Nguyen, Matthew D Terwelp, Vinod H Thourani, Yelin Zhao, Nidal Ganim, Carson Hoffmann, Monica Justo, Anthony L Estrera, Richard W Smalling, Prakash Balan, Joseph Lamelas
OBJECTIVES: Transcatheter aortic valve replacement (TAVR) and minimally invasive aortic valve replacement (MIAVR) have emerged as alternatives to surgical aortic valve replacement (SAVR) via traditional sternotomy. However, their effect on clinical practice remains unclear. The study's objective is to describe clinical trends between TAVR, MIAVR and SAVR in patients with severe aortic stenosis (AS). METHODS: This retrospective observational study analyzed trends in isolated severe aortic valve replacement (AVR) among three high volume TAVR, MIAVR and SAVR centres in the United States...
February 20, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28329081/a-new-preclinical-paradigm-for-testing-anti-aging-therapeutics
#3
Warren Ladiges, Jessica M Snyder, Erby Wilkinson, Denise M Imai, Tim Snider, Xuan Ge, Marcia Ciol, Christina Pettan-Brewer, Smitha P S Pillai, John Morton, Ellen Quarles, Peter Rabinovitch, Laura Niedernhofer, Denny Liggitt
Testing drugs for anti-aging effects has historically been conducted in mouse life-span studies, but are costly and time consuming, and more importantly, difficult to recapitulate in humans. In addition, life-span studies in mice are not well suited to testing drug combinations that target multiple factors involved in aging. Additional paradigms for testing therapeutics aimed at slowing aging are needed. A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a standardized set of guidelines developed to detect the presence or absence of low-impact histopathological lesions and to determine the level of severity of high-impact lesions in organs from aged mice...
February 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329015/adaptive-control-paradigm-for-photovoltaic-and-solid-oxide-fuel-cell-in-a-grid-integrated-hybrid-renewable-energy-system
#4
Sidra Mumtaz, Laiq Khan
The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system...
2017: PloS One
https://www.readbyqxmd.com/read/28328961/steroid-hormone-signaling-during-development-has-a-latent-effect-on-adult-male-sexual-behavior-in-the-butterfly-bicyclus-anynana
#5
Ashley Bear, Kathleen L Prudic, Antónia Monteiro
It is well established that steroid hormones regulate sexual behavior in vertebrates via organizational and activational effects. However, whether the organizational/activational paradigm applies more broadly to the sexual behavior of other animals such as insects is not well established. Here we describe the hormonal regulation of a sexual behavior in the seasonally polyphenic butterfly Bicyclus anynana is consistent with the characteristics of an organizational effect. By measuring hormone titer levels, quantifying hormone receptor gene expression in the brain, and performing hormone manipulations, we demonstrate steroid hormone signaling early in pupal development has a latent effect on adult male sexual behavior in B...
2017: PloS One
https://www.readbyqxmd.com/read/28328885/introducing-therioepistemology-the-study-of-how-knowledge-is-gained-from-animal-research
#6
REVIEW
Joseph P Garner, Brianna N Gaskill, Elin M Weber, Jamie Ahloy-Dallaire, Kathleen R Pritchett-Corning
This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the first time, the scale of the reproducibility and translatability crisis is widely understood beyond the small cadre of researchers who have been studying it and the pharmaceutical and biotech companies who have been living it. Here we argue that an emerging literature, including the papers in this focus issue, has begun to congeal around a set of recurring themes, which themselves represent a paradigm shift. This paradigm shift can be characterized at the micro level as a shift from asking "what have we controlled for in this model?" to asking "what have we chosen to ignore in this model, and at what cost?" At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328747/in-development-%C3%A2-a-new-paradigm-for-understanding-vascular-disease
#7
Nicholas A Flavahan
Under physiological conditions, the arterial endothelium exerts a powerful protective influence to maintain vascular homeostasis. However, during the development of vascular disease, these protective activities are lost and dysfunctional endothelial cells actually promote disease pathogenesis. Numerous investigations have analyzed the characteristics of dysfunctional endothelium with a view to understanding the processes responsible for the dysfunction and to determining their role in vascular pathology. The present review adopts an alternate approach: reviewing the mechanisms that contribute to the initial formation of a healthy protective endothelium and on how those mechanisms may be disrupted, precipitating the appearance of dysfunctional endothelial cells and the progression of vascular disease...
March 17, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28328574/the-long-term-reliability-of-static-and-dynamic-quantitative-sensory-testing-in-healthy-individuals
#8
Anna Marcuzzi, Paul J Wrigley, Catherine M Dean, Roger Adams, Julia M Hush
Quantitative sensory tests (QST) have been increasingly used to investigate alterations in somatosensory function in a wide range of painful conditions. The interpretation of these findings is based on the assumption that the measures are stable and reproducible. To date, reliability of QST has been investigated for short test-retest intervals. The aim of this study was to investigate the long-term reliability of a multimodal QST assessment in healthy people, with testing conducted on three occasions over 4-months...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28328499/importance-of-matching-physical-friction-hardness-and-texture-in-creating-realistic-haptic-virtual-surfaces
#9
Heather Culbertson, Katherine J Kuchenbecker
Interacting with physical objects through a tool elicits tactile and kinesthetic sensations that comprise your haptic impression of the object. These cues, however, are largely missing from interactions with virtual objects, yielding an unrealistic user experience. This article evaluates the realism of virtual surfaces rendered using haptic models constructed from data recorded during interactions with real surfaces. The models include three components: surface friction, tapping transients, and texture vibrations...
January 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28328297/a-revitalizing-look-at-simulation-education-and-at-new-paradigms-of-training-in-surgery-robotics-and-in-the-operating-room
#10
P Marco Fisichella
No abstract text is available yet for this article.
March 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28327983/changing-paradigms-in-the-endovascular-management-of-ruptured-anterior-communicating-artery-aneurysms
#11
Karam Moon, Min S Park, Felipe C Albuquerque, Michael R Levitt, Celene B Mulholland, Cameron G McDougall
BACKGROUND: Approximately 17% of ruptured anterior communicating artery (ACoA) aneurysms were deemed unsuitable for coil embolization during the Barrow Ruptured Aneurysm Trial (BRAT), most commonly due to unfavorable dome-to-neck ratio or small size. OBJECTIVE: To compare patients treated by coil embolization for ruptured ACoA aneurysms during the trial to those treated after the trial to determine whether advances in endovascular techniques have allowed for effective treatment of these lesions...
January 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327228/two-faces-of-social-psychological-realism
#12
Nicholas Hoover Wilson, Julie Y Huang
This commentary places Jussim (2012) in dialogue with sociological perspectives on social reality and the political-academic nature of scientific paradigms. Specifically, we highlight how institutions, observers, and what is being observed intersect, and discuss the implications of this intersection on measurement within the social world. We then identify similarities between Jussim's specific narrative regarding social perception research, with noted patterns of scientific change.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327216/the-expressive-rationality-of-inaccurate-perceptions
#13
Dan M Kahan
This commentary uses the dynamic of identity-protective cognition to pose a friendly challenge to Jussim (2012). Like other forms of information processing, this one is too readily characterized as a bias. It is no mistake, however, to view identity-protective cognition as generating inaccurate perceptions. The "bounded rationality" paradigm incorrectly equates rationality with forming accurate beliefs. But so does Jussim's critique.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327173/a-new-paradigm-for-aedes-spp-surveillance-using-gravid-ovipositing-sticky-trap-and-ns1-antigen-test-kit
#14
Sai Ming Lau, Tock H Chua, Wan-Yussof Sulaiman, Sylvia Joanne, Yvonne Ai-Lian Lim, Shamala Devi Sekaran, Karuthan Chinna, Balan Venugopalan, Indra Vythilingam
BACKGROUND: Dengue remains a serious public health problem in Southeast Asia and has increased 37-fold in Malaysia compared to decades ago. New strategies are urgently needed for early detection and control of dengue epidemics. METHODS: We conducted a two year study in a high human density dengue-endemic urban area in Selangor, where Gravid Ovipositing Sticky (GOS) traps were set up to capture adult Aedes spp. mosquitoes. All Aedes mosquitoes were tested using the NS1 dengue antigen test kit...
March 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28326988/discrimination-and-identification-of-a-third-formant-frequency-cue-to-place-of-articulation-by-young-children-and-adults
#15
Kelly Richardson, Joan E Sussman
Typically-developing children, 4 to 6 years of age, and adults participated in discrimination and identification speech perception tasks using a synthetic consonant-vowel continuum ranging from /da/ to /ga/. The seven-step synthetic /da/-/ga/ continuum was created by adjusting the first 40 ms of the third formant frequency transition. For the discrimination task, listeners participated in a Change/No-Change paradigm with four different stimuli compared to the endpoint-1 /da/ token. For the identification task, listeners labeled each token along the /da/-/ga/ continuum as either "DA" or "GA...
March 2017: Language and Speech
https://www.readbyqxmd.com/read/28326968/item-method-directed-forgetting-and-working-memory-capacity-a-hierarchical-multinomial-modeling-approach
#16
Ivan Marevic, Nina R Arnold, Jan Rummel
Intentional forgetting of information that has recently been encoded is regarded an active and adaptive process and is widely studied using the item-method or the list-method directed forgetting (DF) paradigm. In the present research, we tested whether inter-individual differences in working-memory capacity (WMC), that have been identified as a relevant predictor of DF within the list-method, are also related to stronger DF effects within the item-method. Furthermore, we investigated relationships between WMC and item-method DF at different processing stages by applying the multinomial storage-retrieval model (Riefer & Rouder, 1992) hierarchically to our data...
March 22, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28326919/an-introduction-to-the-origins-history-and-principles-of-ethnography
#17
Gemma Sinead Ryan
Background Ethnography is embedded in the history of research and has been considered a methodology in its own right. Its long history means those new to ethnography may find it complex to navigate the differing perspectives and its historical context. Philosophical perspectives further compound the complexities of understanding and making decisions about method. Aim To introduce the historical context of ethnography and its wide-ranging and differing perspectives. Discussion This paper provides an overview of the historical context of ethnography and discusses the different approaches to ethnography based on philosophical paradigms...
March 22, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/28326720/-novel-peer-instruction-oriented-dental-school-education
#18
Liu Chengcheng, Zhou Xuedong, Xu Xin
Peer instruction is one of the best recognized teaching methods in the world. In this study, we aim to discuss the necessity and feasibility of applying peer instruction to the current dental school education with respect to the specialty features of stomatology in China. We also propose a new paradigm of teaching based on peer instruction for the development of a more effective system to train elite dentists and meet the increasing needs of the society for oral health.
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326608/dnazyme-aptamer-or-aptamer-dnazyme-paradigm-biochemical-approach-for-aflatoxin-analysis
#19
Marzieh Jafari, Mohsen Rezaei, Heibatullah Kalantari, Maryam Tabarzad, Bahram Daraei
DNAzyme and aptamer conjugations have already been used for sensitive and accurate detection of several molecules. In this study, we tested the relationship between conjugation orientation of DNAzyme and Aflatoxin B1 aptamer and their subsequent peroxidase activity. Circular dichroism (CD) spectroscopy and biochemical analysis were used here to difference between these two conjugation patterns. Results showed that DNAzyme-aptamer has more catalytic activity and efficiency than aptamer-DNAzyme. Thereby, DNAzyme-aptamer with its superior efficiency can be used for design and development of more sensitive Aflatoxin B1 DNA based biosensors...
March 22, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28326228/innovations-from-the-ivory-tower-wilhelm-barthlott-and-the-paradigm-shift-in-surface-science
#20
Christoph Neinhuis
This article is mainly about borders that have tremendous influence on our daily life, although many of them exist and act mostly unrecognized. In this article the first objective will be to address more generally the relation between university and society or industry, borders within universities, borders in thinking and the huge amount of misunderstandings and losses resulting from these obvious or hidden borders. In the second part and in more detail, the article will highlight the impact of the research conducted by Wilhelm Barthlott throughout his scientific career during which not only one border was removed, shifted or became more penetrable...
2017: Beilstein Journal of Nanotechnology
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