keyword
MENU ▼
Read by QxMD icon Read
search

paradigms

keyword
https://www.readbyqxmd.com/read/28938336/arterial-stiffness-induced-by-carotid-calcification-leads-to-cerebral-gliosis-mediated-by-oxidative-stress
#1
Nataliya Sadekova, M Florencia Iulita, Diane Vallerand, Gervais Muhire, Mohamed Bourmoum, Audrey Claing, Hélène Girouard
BACKGROUND: Arterial stiffness is a risk factor for cognitive decline and dementia. However, its precise effects on the brain remain unexplored. Using a mouse model of carotid stiffness, we investigated its effect on glial activation and oxidative stress. METHODS: Arterial stiffness was induced by the application of calcium chloride to the adventitial region of the right carotid. Superoxide anion production, NADPH activity and levels, as well as glial activation were examined with immunohistochemical and biochemical approaches, 2-week postcalcification...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938124/the-kinetochore-receptor-for-the-cohesin-loading-complex
#2
Stephen M Hinshaw, Vasso Makrantoni, Stephen C Harrison, Adèle L Marston
The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. We have exploited this system to determine the mechanism of specific cohesin recruitment...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938114/the-eukaryotic-co2-concentrating-organelle-is-liquid-like-and-exhibits-dynamic-reorganization
#3
Elizabeth S Freeman Rosenzweig, Bin Xu, Luis Kuhn Cuellar, Antonio Martinez-Sanchez, Miroslava Schaffer, Mike Strauss, Heather N Cartwright, Pierre Ronceray, Jürgen M Plitzko, Friedrich Förster, Ned S Wingreen, Benjamin D Engel, Luke C M Mackinder, Martin C Jonikas
Approximately 30%-40% of global CO2 fixation occurs inside a non-membrane-bound organelle called the pyrenoid, which is found within the chloroplasts of most eukaryotic algae. The pyrenoid matrix is densely packed with the CO2-fixing enzyme Rubisco and is thought to be a crystalline or amorphous solid. Here, we show that the pyrenoid matrix of the unicellular alga Chlamydomonas reinhardtii is not crystalline but behaves as a liquid that dissolves and condenses during cell division. Furthermore, we show that new pyrenoids are formed both by fission and de novo assembly...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28938088/small-molecule-inhibitors-targeting-dna-repair-and-dna-repair-deficiency-in-research-and-cancer-therapy
#4
REVIEW
Sarah R Hengel, M Ashley Spies, Maria Spies
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude of deleterious DNA lesions, which arise constantly in every cell. Processes that support genome integrity in normal cells, however, allow cancer cells to develop resistance to radiation and DNA-damaging chemotherapeutics. Chemical inhibition of the key DNA repair proteins and pharmacologically induced synthetic lethality have become instrumental in both dissecting the complex DNA repair networks and as promising anticancer agents...
September 21, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28937994/modeling-of-annexin-a2-membrane-interactions-by-molecular-dynamics-simulations
#5
Davit Hakobyan, Volker Gerke, Andreas Heuer
The annexins are a family of Ca2+-regulated phospholipid binding proteins that are involved in membrane domain organization and membrane trafficking. Although they are widely studied and crystal structures are available for several soluble annexins their mode of membrane association has never been studied at the molecular level. Here we obtained molecular information on the annexin-membrane interaction that could serve as paradigm for the peripheral membrane association of cytosolic proteins by Molecular Dynamics simulations...
2017: PloS One
https://www.readbyqxmd.com/read/28937805/laparoscopic-partial-nephrectomy-a-narrative-review-and-comparison-with-open-and-robotic-partial-nephrectomy
#6
Andrew M Ng, Paras H Shah, Louis R Kavoussi
INTRODUCTION: Kidney cancer ranks among the top 10 most prevalent cancers in Western society, ∼90% of which are renal cell carcinomas. There has been a paradigm shift in the management of small renal masses with strong emphasis now placed on nephron-sparing surgery and increased utilization of laparoscopic approaches to partial nephrectomy. In this review, the current state of laparoscopic partial nephrectomy (LPN) is discussed. EVIDENCE ACQUISITION: The PubMed database was queried using the MeSH terms "laparoscopy" and "nephrectomy," as well as the search term "partial...
September 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28937772/terahertz-light-matter-interaction-beyond-unity-coupling-strength
#7
Andreas Bayer, Marcel Pozimski, Simon Schambeck, Dieter Schuh, Rupert Huber, Dominique Bougeard, Christoph Lange
Achieving control over light-matter interaction in custom-tailored nanostructures is at the core of modern quantum electrodynamics. In strongly and ultrastrongly coupled systems, the excitation is repeatedly exchanged between a resonator and an electronic transition at a rate known as the vacuum Rabi frequency ΩR. For ΩR approaching the resonance frequency ωc, novel quantum phenomena including squeezed states, Dicke superradiant phase transitions, the collapse of the Purcell effect, and a population of the ground state with virtual photon pairs are predicted...
September 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28937454/life-expectancy-and-metastatic-spine-scoring-systems-an-academic-institutional-experience
#8
Brian T Ragel, Gustavo A Mendez, Justin Reddington, David Ferachi, Charlotte D Kubicky, Travis C Philipp, Natalie L Zusman, Paul Klimo, Robert Hart, Jung Yoo, Alex C Ching
STUDY DESIGN: A retrospective data collection study with application of metastatic spine scoring systems. OBJECTIVES: To apply the Tomita and revised Tokuhashi scoring systems to a surgical cohort at a single academic institution and analyze spine-related surgical morbidity and mortality rates. SUMMARY OF BACKGROUND DATA: Surgical management of metastatic spine patients requires tools that can accurately predict patient survival, as well as knowledge of morbidity and mortality rates...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937410/cerebral-oxygenation-of-premature-lambs-supported-by-an-artificial-placenta
#9
Ahmed M El-Sabbagh, Brian W Gray, Andrew W Shaffer, Benjamin S Bryner, Joseph T Church, Jennifer S McLeod, Sara Zakem, Elena M Perkins, Renée A Shellhaas, John D E Barks, Alvaro Rojas-Peña, Robert H Bartlett, George B Mychaliska
An artificial placenta (AP) using venovenous extracorporeal life support (VV-ECLS) could represent a paradigm shift in the treatment of extremely premature infants. However, AP support could potentially alter cerebral oxygen delivery. We assessed cerebral perfusion in fetal lambs on AP support using near-infrared spectroscopy (NIRS) and carotid arterial flow (CAF). Fourteen premature lambs at EGA 130 days (term = 145) underwent cannulation of the right jugular vein and umbilical vein with initiation of VV-ECLS...
September 20, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28937301/attentional-modulation-and-individual-differences-in-explaining-the-changing-role-of-fundamental-frequency-in-korean-laryngeal-stop-perception
#10
Eun Jong Kong, Hyunjung Lee
Previous research has shown differential degrees of attention in processing hierarchical linguistic information where higher order cues require greater attention in speech processing. The current study investigated the influence of attentional resources on acoustic cue weightings in speech perception by examining Korean listeners' identifications of the three-way laryngeal stops (tense vs. lax vs. aspirated). Using a dual-task paradigm, we presented 28 adult Korean listeners with identification tasks blocked by no-distractor versus distractor conditions where arithmetic calculations distracted the listeners' speech processing...
September 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/28937118/how-can-we-provide-person-centred-dental-care
#11
N Apelian, J N Vergnes, R Hovey, C Bedos
Patient- or person-centred care is the current paradigm in the health profession yet there is still no clear understanding of what it means or how it could be implemented in dentistry. Building on a previously proposed person-centred model in clinical dentistry, in this article a person-centred dental clinical approach is presented. The approach consists of three guiding principles - humility, hospitality and mindfulness - that influence the different processes of the dental clinical encounter: connecting, examining, sharing, and intervening...
September 22, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28936394/intercultural-policy-in-times-of-crisis-theory-and-practice-in-the-case-of-turin-italy
#12
Tiziana Caponio, Davide Donatiello
In this article we analyse how interculturalism, intended as a new paradigm of immigrant integration policies, has been taking shape in an Italian city, i.e. Turin, in the context of the current economic crisis. We argue for the necessity of going beyond official statements on intercultural policy by undertaking a comparative analysis of policy practices in three Neighbourhood Houses (NHs, Case del quartiere), which are defined by the Municipality as open and intercultural spaces in which associations and citizens can develop activities aimed at expressing different cultural backgrounds, fostering participation and supporting social inclusion...
2017: Comparative Migration Studies
https://www.readbyqxmd.com/read/28936272/hereditary-gynaecologic-cancers-in-nepal-a-proposed-model-of-care-to-serve-high-risk-populations-in-developing-countries
#13
Hanoon P Pokharel, Neville F Hacker, Lesley Andrews
BACKGROUND: Endometrial, ovarian and breast cancers are paradigms for global health disparity. Women living in the developing world continue to present in later stages of disease and have fewer options for treatment than those in developed countries. Risk reducing surgery is of proven benefit for women at high risk of gynaecological cancer. There is no specific model for identification and management of such women in the developing world. METHODS: We have integrated data from our published audit of a major gynaecological oncology centre at Royal Hospital for Women in Australia, with data from our survey and a focus group discussion of Nepalese gynaecological health care professionals regarding genetic testing, and findings from the literature...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28936110/a-working-paradigm-for-the-treatment-of-obesity-in-gastrointestinal-practice
#14
Andres Acosta, Michael Camilleri
Obesity is a chronic, relapsing, multi-factorial disease characterized by abnormal or excessive adipose tissue accumulation that may impair health and increase disease risks. Despite the ever-increasing prevalence and economic and societal burden, the current approaches to treat obesity are not standardized or generally effective. In this manuscript, we describe a current working paradigm developed by a consensus approach for the multidisciplinary treatment of obesity in the GI practice. Obesity should be managed as a continuum of care focusing on weight loss, weight loss maintenance and prevention of weight regain...
January 2017: Techniques in Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28935966/silent-sentence-completion-shows-superiority-localizing-wernicke-s-area-and-activation-patterns-of-distinct-language-paradigms-correlate-with-genomics-prospective-study
#15
Kamel El Salek, Islam S Hassan, Aikaterini Kotrotsou, Srishti Abrol, Scott H Faro, Feroze B Mohamed, Pascal O Zinn, Wei Wei, Nan Li, Ashok J Kumar, Jeffrey S Weinberg, Jeffrey S Wefel, Shelli R Kesler, Ho-Ling Anthony Liu, Ping Hou, R Jason Stafford, Sujit Prabhu, Raymond Sawaya, Rivka R Colen
Preoperative mapping of language areas using fMRI greatly depends on the paradigms used, as different tasks harness distinct capabilities to activate speech processing areas. In this study, we compared the ability of 3 covert speech paradigms: Silent Sentence Completion (SSC), category naming (CAT) and verbal fluency (FAS), in localizing the Wernicke's area and studied the association between genomic markers and functional activation. Fifteen right-handed healthy volunteers and 35 mixed-handed patients were included...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935924/multipurpose-silicon-photonics-signal-processor-core
#16
Daniel Pérez, Ivana Gasulla, Lee Crudgington, David J Thomson, Ali Z Khokhar, Ke Li, Wei Cao, Goran Z Mashanovich, José Capmany
Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935774/immunotherapy-a-new-and-old-approach-to-treatment-of-soft-tissue-and-bone-sarcomas
#17
REVIEW
Michael J Nathenson, Anthony P Conley, Edward Sausville
Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28935548/chronic-subdural-hematoma-a-historical-and-clinical-perspective
#18
REVIEW
Ronald Sahyouni, Khodayar Goshtasbi, Amin Mahmoodi, Diem K Tran, Jefferson W Chen
Chronic subdural hematoma (cSDH) affects 1-5.3 per 100,000 individuals annually, with the incidence expected to rise as the U.S. population ages. The symptoms of cSDH are often nonspecific, with headaches being the most common complaint. Other symptoms include weakness, balance and gait problems, and memory problems. A variety of clinical factors must be taken into account in the treatment of cSDH, and the multifaceted treatment paradigms continue to evolve. This review aims to highlight the clinical complexity of cSDH, while presenting a brief historical discussion of cSDH...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28935479/progressive-ratio-pr-schedules-and-the-sipometer-do-they-measure-wanting-liking-and-or-reward-a-tribute-to-anthony-sclafani-and-karen-ackroff
#19
H R Kissileff, M Herzog
This paper honors the contributions made by Anthony (Tony) Sclafani and Karen Ackroff to both the Columbia University Seminar on Appetitive Behavior and to the field of ingestive behavior in general. We review their use of the progressive ratio (PR) licking paradigm, to determine whether the taste of sucrose, independent of its post-ingestive effects, is always positively reinforcing in animals. They demonstrated a monotonic increase in licking as concentration increased, and obtained results identical to those obtained with a lever-pressing paradigm, but licking was easier and more natural than lever pressing...
September 18, 2017: Appetite
https://www.readbyqxmd.com/read/28935268/repeated-cortisol-administration-does-not-reduce-intrusive-memories-a-double-blind-placebo-controlled-experimental-study
#20
Alexandra Heike Graebener, Tanja Michael, Elena Holz, Johanna Lass-Hennemann
PTSD is a severe mental disorder, which may develop after exposure to traumatic events and is characterized by intrusive memories. Intrusions are sudden brief sensory memories of the traumatic event, that cause immense distress and impairment in every day functioning. Thus, the reduction of intrusive memories is one of the main aims of PTSD therapy. Recently, the glucocorticoid cortisol has been proposed as a pharmacological option to reduce intrusive memories, because cortisol is known to have memory retrieval inhibiting effects...
September 18, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
keyword
keyword
100300
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"