Diabetes milletus

The sulfonylurea urea drug glyburide (glibenclamide) is widely used for the treatment of diabetes milletus and gestational diabetes. In previous studies monohydroxylated metabolites were identified and characterized for glyburide in different species, but the metabolite owing to the loss of cyclohexyl ring was identified only in mouse. Glyburide upon incubation with hepatic microsomes resulted in 10 metabolites for human. The current study identifies new metabolites of glyburide along with the hydroxylated metabolites that were reported earlier...

Diabetes Milletus is a disease which has a major impact in our society due to the number of people who suffer this disease; due to the multiple complications, both chronic and acute, which it can cause; due to the repercussions it causes among family and relatives,... Therefore, providing patients a good diabetic educational program which improves metabolic control and offers help in a patient's environment becomes very necessary; at the same time, it is essential to provide patients information about new techniques...

Stroke, caused by either infartion or subarachnoid haemorrhage, can have devastating and debilitating effect on its victims. Traditional therapy has focused on the risk factors of hypertension, hyperlipidemia, atherosclerotic heart disease and diabetes milletus. More recently, the literature has focused on smoking and the short and long term effects of cerebral blood flow. The purpose of this paper will be to review the most recent research literature on both the chronic and acute effects of smoking on the cerebral vascular system...