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https://www.readbyqxmd.com/read/28550007/associations-between-maternal-depressive-symptoms-and-nonresponsive-feeding-styles-and-practices-in-mothers-of-young-children-a-systematic-review
#1
Ana Cristina Lindsay, Tatiana Mesa, Mary L Greaney, Sherrie F Wallington, Julie A Wright
BACKGROUND: Childhood obesity is a significant global public health problem due to increasing rates worldwide. Growing evidence suggests that nonresponsive parental feeding styles and practices are important influences on children's eating behaviors and weight status, especially during early childhood. Therefore, understanding parental factors that may influence nonresponsive parental feeding styles and practices is significant for the development of interventions to prevent childhood obesity...
May 26, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28549558/the-kv1-3-channel-blocker-vm24-enhances-muscle-glucose-transporter-4-mobilization-but-does-not-reduce-body-weight-gain-in-diet-induced-obese-male-rats
#2
Lorraine Jaimes-Hoy, Georgina B Gurrola, Miguel Cisneros, Patricia Joseph-Bravo, Lourival D Possani, Jean-Louis Charli
AIMS: Voltage-gated potassium channels 1.3 (Kv1.3) can be targeted to reduce diet-induced obesity and insulin resistance in mice. Since species-specific differences in Kv1.3 expression and pharmacology have been observed, we tested the effect of Vm24, a high-affinity specific blocker of Kv1.3 channels from Vaejovis mexicanus smithi, on body weight (BW), glucose tolerance and insulin resistance in diet-induced obese rats. MATERIALS AND METHODS: Young adult male Wistar rats were switched to a high-fat/high-fructose (HFF) diet...
May 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/28547122/trauma-and-bmi-mortality
#3
REVIEW
Tejal S Brahmbhatt, Michael Hernon, Charles Jeffrey Siegert, Leneé Plauché, Lorrie S Young, Peter Burke
PURPOSE OF REVIEW: Obesity has been recognized as an impactful comorbid condition. It has been demonstrated to be an independent risk factor for morbidity and mortality following trauma. RECENT FINDINGS: Multiple studies and reviews have strongly suggested obesity to be associated with increased risk for post-injury morbidity and mortality. As obesity is associated with a pro-inflammatory state, it has been suggested to negatively affect the respiratory, cardiovascular, coagulation, and renal systems and the ability and manner in which an obese patient heals...
May 25, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28545035/novel-ppar%C3%AE-agonist-mhy553-alleviates-hepatic-steatosis-by-increasing-fatty-acid-oxidation-and-decreasing-inflammation-during-aging
#4
Seong Min Kim, Bonggi Lee, Hye Jin An, Dae Hyun Kim, Kyung Chul Park, Sang-Gyun Noh, Ki Wung Chung, Eun Kyeong Lee, Kyung Mok Kim, Do Hyun Kim, Su Jeong Kim, Pusoon Chun, Ho Jeong Lee, Hyung Ryong Moon, Hae Young Chung
Hepatic steatosis is frequently observed in obese and aged individuals. Because hepatic steatosis is closely associated with metabolic syndromes, including insulin resistance, dyslipidemia, and inflammation, numerous efforts have been made to develop compounds that ameliorate it. Here, a novel peroxisome proliferator-activated receptor (PPAR) α agonist, 4-(benzo[d]thiazol-2-yl)benzene-1,3-diol (MHY553) was developed, and investigated its beneficial effects on hepatic steatosis using young and old Sprague-Dawley rats and HepG2 cells...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544229/clinical-heterogeneity-of-type-1-diabetes-t1d-found-in-asia
#5
REVIEW
Yongsoo Park, Kupper A Wintergerst, Zhiguang Zhou
Diabetes mellitus among young patients in Asia is caused by a complex set of factors. Although T1D remains the most common form of diabetes in children, the recent unabated increase in obesity has resulted in the emergence of T2D as a new type of diabetes at adolescent and young adult age. In addition to the typical autoimmune type 1 diabetes (T1aD) and type 2 diabetes (T2D) patients, there is a variable incidence of cases of non-autoimmune types of T1D associated with insulin deficiency (T1bD). Additional forms have been described, including fulminant T1D (FT1D)...
May 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28543872/pai-1-gain-of-function-genotype-factors-increasing-pai-1-levels-and-airway-obstruction-the-gala-ii-cohort
#6
Michael G Sherenian, Seong H Cho, Albert Levin, Jin-Young Min, Sam S Oh, Donglei Hu, Joshua Galanter, Saunak Sen, Scott Huntsman, Celeste Eng, Jose R Rodriguez-Santana, Denise Serebrisky, Pedro C Avila, Ravi Kalhan, Lewis J Smith, Luisa N Borrell, Max A Seibold, L Keoki Williams, Esteban G Burchard, Rajesh Kumar
BACKGROUND: PAI-1 gain of function variants promote airway fibrosis, and are associated with asthma and with worse lung function in subjects with asthma. OBJECTIVE: We sought to determine if the association of a gain-of-function polymorphism in Plasminogen Activator Inhibitor -1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level. METHODS: We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort...
May 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28541599/improvement-of-left-ventricular-diastolic-function-and-left-heart-morphology-in-young-women-with-morbid-obesity-six-months-after-bariatric-surgery
#7
Katarzyna Kurnicka, Justyna Domienik-Karłowicz, Barbara Lichodziejewska, Maksymilian Bielecki, Marta Kozłowska, Sylwia Goliszek, Olga Dzikowska-Diduch, Wojciech Lisik, Maciej Kosieradzki, Piotr Pruszczyk
BACKGROUND: Obesity contributes to left ventricular diastolic dysfunction (LVDD) and may lead to diastolic heart failure. Weight loss (WL) after bariatric surgery (BS) may influence LV morphology and function. Using echocardiography, this study assessed the effect of WL on LV diastolic function (LVDF) and LV and left atrium (LA) morphology 6 months after BS in young women with morbid obesity. METHODS: Echocardiography was performed in 60 women with BMI ≥ 40kg/m², aged 37...
May 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28540309/diabetes-risk-score-in-a-young-student-population-in-jordan-a-cross-sectional-study
#8
Abdel-Ellah Al-Shudifat, Amjad Al-Shdaifat, Ahmad Ali Al-Abdouh, Mohammad Ibrahim Aburoman, Sara Mohammad Otoum, Amro Ghaleb Sweedan, Ibrahim Khrais, Ibrahim Hisham Abdel-Hafez, Asgeir Johannessen
Background. The Middle East is the home to the most obese population in the world, and type 2 diabetes mellitus is endemic in the region. However, little is known about risk factors for diabetes in the younger age groups. Methods. The Finnish Diabetes Risk Score (FINDRISC) is a simple, validated tool to identify persons at risk of diabetes. We investigated students at Hashemite University in Jordan with FINDRISC and measured fasting plasma glucose in those who were categorized in the high-risk group. Results...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28539724/anti-differentiation-effect-of-b-d-seco-limonoids-of-swietenia-mahogani
#9
Heejung Yang, Mina Choi, Dong Young Lee, Sang Hyun Sung
BACKGROUND: Obesity is a pathological state caused by abnormal or excessive accumulation of fat. Swietenia mahogani JACQ., known as West Indian mahogany, is a medium-sized semi-evergreen tree belonging to Meliaceae. Their seeds are used in Indonesian folk medicine as a treatment for hypertension, diabetes, malaria, and it also has anti-feedant activities. The major components of S. mahogani are B, D-seco limonoids, a type of irregular triterpenes are well known. OBJECTIVE: We tried to find the bioactive components, which have the inhibitory activity on adipocyte differentiation from the seeds of S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539336/nutritional-regulation-of-renal-lipogenic-factor-expression-in-mice-comparison-to-regulation-in-the-liver-and-skeletal-muscle
#10
Suk-Jeong Kim, Ji-Eun Kim, Yong-Woon Kim, Jong-Yeon Kim, So-Young Park
Regulation of lipogenesis by pathophysiological factors in the liver and skeletal muscle is well understood; however, regulation in the kidney is still unclear. To elucidate nutritional regulation of lipogenic factors in the kidney, we measured the renal expression of lipogenic transcriptional factors and enzymes during fasting and refeeding in chow-fed and high-fat-fed mice. We also examined the regulatory effect of the liver X receptor (LXR) on the expression of lipogenic factors. The renal gene expression of sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS) was reduced by fasting for 48 h and restored by refeeding, whereas the mRNA levels of forkhead box O (FOXO)1/3 were increased by fasting and restored by refeeding...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28535752/four-year-trends-in-adiposity-and-its-association-with-hypertension-in-serial-groups-of-young-adult-university-students-in-urban-cameroon-a-time-series-study
#11
Simeon-Pierre Choukem, André-Pascal Kengne, Maxime-Leolein Nguefack, Yannick Mboue-Djieka, Daniel Nebongo, Jackson T Guimezap, Jean Claude Mbanya
BACKGROUND: Obesity is a major risk factor for non-communicable diseases (NCDs) and is growing rapidly globally including in sub-Saharan Africa (SSA). We aimed to assess the trend in adiposity markers in Cameroonian university students, and investigated their associations with hypertension. METHODS: From 2009 to 2012, we annually measured weight, height, blood pressure, waist (WC) and hip circumferences, and calculated the body mass index (BMI) and other indices of adiposity in consecutive students aged 18 years or above, during their registration...
May 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28534931/leucine-rich-glioma-inactivated-3-integrative-analyses-support-its-role-in-the-cytokine-network
#12
Hyun A Kim, Nyoun Soo Kwon, Kwang Jin Baek, Dong-Seok Kim, Hye-Young Yun
Leucine-rich glioma inactivated (LGI)3 is a secreted protein member of LGI family. We previously repo-rted that LGI3 was upregulated in adipose tissues from obese mice and suppressed adipogenesis through its receptor, a disintegrin and metalloproteinase domain-containing protein 23 (ADAM23). We demonstrated that LGI3 regulated tumor necrosis factor-α and adiponectin, and proposed that LGI3 may be a pro-inflammatory adipokine involved in adipose tissue inflammation. In this study, we analyzed adipokine and cytokine profiles in LGI3 knockout mice and demonstrated that multiple factors were increased or decreased in the adipose tissues and plasma of the LGI3 knockout mice...
May 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28532405/red-meat-and-chicken-consumption-and-its-association-with-high-blood-pressure-and-obesity-in-south-korean-children-and-adolescents-a-cross-sectional-analysis-of-kshes-2011-2015
#13
Geum Hee Kim, Sang Won Shin, Juneyoung Lee, Jun Hyun Hwang, Soon-Woo Park, Jin Soo Moon, Hyun Jung Kim, Hyeong Sik Ahn
BACKGROUND: The impact of meat consumption on high blood pressure (HBP) and obesity in children and adolescents is a subject of debate. The aim of this study was thus to evaluate the association between meat consumption and both HBP and obesity in this group. METHODS: We performed a cross-sectional analysis using nationally representative samples of children and adolescents aged 9, 12, and 15 years old (n = 136,739) who were included in the Korea School Health Examination Survey (KSHES) for the 2011-2015 period...
May 22, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28527745/early-life-protein-intake-food-sources-correlates-and-tracking-across-the-first-5-years-of-life
#14
Karen J Campbell, Gavin Abbott, Miaobing Zheng, Sarah A McNaughton
BACKGROUND: High consumption of protein has been associated with accelerated growth and adiposity in early childhood. OBJECTIVE: To describe intake, food sources, correlates, and tracking of protein in young children. DESIGN: Secondary analysis of Melbourne Infant Feeding Activity and Nutrition Trial (InFANT). Dietary data were collected using three 24-hour dietary recalls at ages 9 and 18 months as well as 3.5 and 5 years. PARTICIPANTS/SETTING: First-time mothers and their child (n=542) participated in an 18-month intervention to prevent childhood obesity and the cohort was followed-up with no intervention when children were aged 3...
May 16, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#15
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
May 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28525800/what-is-the-association-between-healthy-weight-in-4-5-year-old-children-and-spatial-access-to-purposefully-constructed-play-areas
#16
Robin Poole, Graham Moon
BACKGROUND: Childhood obesity is a global issue. Understanding associated factors is essential in designing interventions to reduce its prevalence. There are knowledge gaps concerning the leptogenic potential of play areas for very young children and particularly whether there is an association between levels of childhood obesity and play area quality. METHODS: A cross-sectional observational study was conducted to investigate whether spatial access to play areas had an association with healthy weight status of 4-5-year-old children...
May 15, 2017: Health & Place
https://www.readbyqxmd.com/read/28525355/does-body-fat-percentage-predict-post-exercise-heart-rate-response-in-non-obese-children-and-adolescents
#17
Tatjana Jezdimirovic, Valdemar Stajer, Sasa Semeredi, Julio Calleja-Gonzalez, Sergej M Ostojic
BACKGROUND: A correlation between adiposity and post-exercise autonomic regulation has been established in overweight and obese children. However, little information exists about this link in non-obese youth. The main purpose of this cross-sectional study was to describe the relationship between body fat percentage (BFP) and heart rate recovery after exercise [post-exercise heart rate (PEHR)], a marker of autonomic regulation, in normal-weight children and adolescents. METHODS: We evaluated the body composition of 183 children and adolescents (age 15...
May 18, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28522388/trends-in-socioeconomic-costs-of-morbid-obesity-among-korean-adults-2009-2013-data-from-national-health-insurance-service
#18
Jae-Woo Lee, Young-Eun Choi, Dong-Wook Kim, Sunmi Lee, Kyung-Hee Cho
As the prevalence of morbid obesity increased in Korea, the estimation of the accurate socioeconomic costs by morbid obesity was required; we analysed national medical costs through the big data. From 2009 year to 2013 year, Direct Costs (DC) for medical costs, transit costs and nursing costs and Indirect Costs (IC) for Future Income Loss (FIL) and Productivity Loss (PL) of morbid obesity (BMI≥30) were calculated, and socioeconomic costs were estimated by applying Population Attributable Risk (PAR) proportion according to obesity related diseases...
May 15, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28521183/predictors-of-poor-visual-outcome-in-patients-with-idiopathic-intracranial-hypertension-iih-an-ambispective-cohort-study
#19
Amit Agarwal, Deepti Vibha, Kameshwar Prasad, Rohit Bhatia, Mamta Bhushan Singh, Ajay Garg, Rohit Saxena
OBJECTIVE: Idiopathic intracranial hypertension (IIH) is a disease of young with threat to vision if not diagnosed timely. This study looked at the putative predictors of poor visual outcome in patients with IIH at six months after presentation via a cohort study. PATIENTS AND METHODS: All patients diagnosed with IIH from January 2011 to May 2015 were enrolled. The study design was ambispective cohort study. The baseline clinical and radiological characteristics assessed were age, sex, body mass index (BMI), duration of symptoms, transient visual obscuration, cranial nerve palsy, diminution of vision, Cerebrospinal fluid (CSF) opening pressure, empty sella, optic nerve dilatation, global configuration and transverse sinus stenosis...
May 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28513622/human-milk-insulin-is-related-to-maternal-plasma-insulin-and-bmi-but-other-components-of-human-milk-do-not-differ-by-bmi
#20
B E Young, Z Patinkin, C Palmer, B de la Houssaye, L A Barbour, T Hernandez, J E Friedman, N F Krebs
BACKGROUND/OBJECTIVES: The impact of maternal BMI and insulin sensitivity on bioactive components of human milk (HM) is not well understood. As the prevalence of obesity and diabetes rises, it is increasingly critical that we understand how maternal BMI and hormones associated with metabolic disease relate to concentrations of bioactive components in HM. SUBJECTS/METHODS: This longitudinal cohort design followed 48 breastfeeding mothers through the first four months of lactation, collecting fasting morning HM samples at 2-weeks and 1, 2, 3 and 4-months, and fasting maternal blood at 2-weeks and 4-months...
May 17, 2017: European Journal of Clinical Nutrition
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