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https://www.readbyqxmd.com/read/29665829/effect-of-a-low-intensity-self-management-lifestyle-intervention-on-knee-pain-in-community-based-young-to-middle-aged-rural-women-a-cluster-randomised-controlled-trial
#1
Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R E Brady, Helena Teede, Flavia M Cicuttini
BACKGROUND: Knee pain is common with obesity and weight gain being important risk factors. Previous clinical trials have focused on overweight or obese adults with knee pain and osteoarthritis and demonstrated modest effects of intense weight loss programs on reducing knee pain despite very significant weight loss. There has been no lifestyle intervention that targets community-based adults to test its effect on prevention of knee pain. We aimed to determine the effect of a simple low-intensity self-management lifestyle intervention (HeLP-her), proven in randomised controlled trials to improve lifestyle and prevent weight gain, on knee pain in community-based young to middle-aged rural women...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29665658/effect-of-the-anti-il-17-antibody-on-allergic-inflammation-in-an-obesity-related-asthma-model
#2
Lin Liang, Jung Hur, Ji Young Kang, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee
Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in obese patients by inhibiting interleukin 17 (IL-17) expression. This study investigated the combined effects of pravastatin and anti-IL-17 antibody treatment on allergic inflammation in a mouse model of obesity-related asthma...
April 19, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29665358/hyperinsulinemic-euglycemic-clamp-over-the-first-year-of-use-of-depot-medroxyprogesterone-acetate-as-a-contraceptive
#3
Vaneska Melhado-Kimura, Gisele Almeida Batista, Aglécio Luiz de Souza, Priscilla de Nazaré Silva Dos Santos, Sarah Monte Alegre, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
OBJECTIVE: The literature lacks data on the use of the gold-standard hyperinsulinemic-euglycemic clamp (HEC) technique for the evaluation of insulin resistance (IR) in depot-medroxyprogesterone acetate (DMPA) users. This study assessed carbohydrate metabolism in non-obese users of DMPA using the HEC technique. STUDY DESIGN: A prospective, non-randomized, comparative study conducted at the Family Planning Clinic/Metabolic Unit, University of Campinas, Brazil. Forty-eight women aged 18-39 years underwent HEC: 30 initiating use of DMPA and 18 initiating use of a copper intrauterine device (IUD)...
April 14, 2018: Contraception
https://www.readbyqxmd.com/read/29665180/does-the-earned-income-tax-credit-increase-children-s-weight-the-impact-of-policy-driven-income-on-childhood-obesity
#4
Young Jo
I exploit substantial increases in the earned income tax credit to study how a policy-driven change in family income affects childhood obesity. Using the National Longitudinal Survey of Youth 1979, my difference-in-differences estimates indicate that the probability of being obese increased by 3 percentage points among children whose families experienced a greater income shock. A further investigation suggests that a reduction in maternal time with children played a greater role in children's weight gain than income...
April 17, 2018: Health Economics
https://www.readbyqxmd.com/read/29662264/chromosome-6q24-related-diabetes-mellitus
#5
Tohru Yorifuji, Shinji Higuchi, Yuki Hosokawa, Rie Kawakita
Chromosome 6q24-related diabetes mellitus is the most common cause of transient neonatal diabetes (TNDM), accounting for approximately two-thirds of all TNDM cases. Patients with 6q24-TNDM develop insulin-requiring diabetes soon after birth, followed by the gradual improvement and eventual remission of the disorder by 18 mo of age. The most important clinical feature of affected patients is a small-for-gestational age (SGA) birth weight, which reflects the lack of insulin in utero. It is believed that 6q24-TNDM is caused by the overexpression of the paternal allele of the imprinted locus in chromosome 6q24, which contains only two expressed genes, PLAGL1 and HYMAI...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29662088/tracing-of-the-fecal-microbiota-of-commercial-pigs-at-five-growth-stages-from-birth-to-shipment
#6
Geon Goo Han, Jun-Yeong Lee, Gwi-Deuk Jin, Jongbin Park, Yo Han Choi, Sang-Kee Kang, Byung Jo Chae, Eun Bae Kim, Yun-Jaie Choi
The intestinal microbiota affect various physiological traits of host animals such as brain development, obesity, age, and the immune system. In the swine industry, understanding the relationship between intestinal microbiota and growth stage is essential because growth stage is directly related to the feeding system of pigs, thus we studied the intestinal microbiota of 32 healthy pigs across five sows at 10, 21, 63, 93, and 147 d of ages. The intestinal microbiota were altered with growth of pigs and were separated into three distinct clusters...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662031/the-associations-between-sleep-duration-and-sleep-quality-with-body-mass-index-in-a-large-sample-of-young-adults
#7
Tomislav Krističević, Lovro Štefan, Goran Sporiš
BACKGROUND: The main aims of this study were to explore the associations between time spent in bed (as a proxy of sleep duration) and sleep quality with overweight/obesity status in a large sample of young adults. METHODS: In this cross-sectional study, participants were 2100 university students (49.6% of women). We used Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess time spent in bed and sleep quality. Body-mass index (BMI) was self-reported and dichotomized as normal (<25 kg/m²) vs...
April 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29661687/impact-of-weight-loss-with-intragastric-balloon-on-bone-density-and-microstructure-in-obese-adults
#8
Eduardo Madeira, Miguel Madeira, Erika Paniago Guedes, Thiago Thomaz Mafort, Rodrigo Oliveira Moreira, Laura Maria Carvalho de Mendonça, Inayá Correa Barbosa Lima, Leonardo Vieira Neto, Paulo Roberto Alves de Pinho, Agnaldo José Lopes, Maria Lucia Fleiuss Farias
The historical concept that obesity protects against bone fractures has been questioned. Weight loss appears to reduce bone mineral density (BMD); however, the results in young adults are inconsistent, and data on the effects of weight loss on bone microstructure are limited. This study aimed to evaluate the impact of weight loss using an intragastric balloon (IGB) on bone density and microstructure. Forty obese patients with metabolic syndrome (mean age 35.1 ± 7.3 yr) used an IGB continuously for 6 mo...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29659966/peri-urban-but-not-urban-residence-in-bolivia-is-associated-with-higher-odds-of-co-occurrence-of-overweight-and-anemia-among-young-children-and-of-households-with-an-overweight-woman-and-stunted-child
#9
Andrew D Jones, Lesli Hoey, Jennifer Blesh, Kathryn Janda, Ramiro Llanque, Ana María Aguilar
Background: Urban populations have grown globally alongside emerging simultaneous burdens of undernutrition and obesity. Yet, how heterogeneous urban environments are associated with this nutritional double burden is poorly understood. Objective: We aimed to determine: 1) the prevalence of the nutritional double burden and its components in urban, peri-urban, and rural areas of Bolivia; and 2) the association of residence in these areas with the nutritional double burden and its components...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659630/body-mass-index-of-92-027-patients-acutely-admitted-to-general-hospitals-in-denmark-associated-clinical-characteristics-and-30-day-mortality
#10
Sigrid Bjerge Gribsholt, Lars Pedersen, Bjørn Richelsen, Olaf Dekkers, Reimar Wernich Thomsen
BACKGROUND: Data are sparse on the range of BMI among patients acutely admitted to general hospitals. We investigated BMI values and associated patient characteristics, reasons for hospital admission, and mortality in Denmark. METHODS: We identified all persons with an acute inpatient admission 2011-2014 in Central Denmark Region and assessed BMI measurements recorded in the Clinical Information System. We used cross-sectional and cohort analyses to examine the BMI distribution and its association with demographic characteristics, comorbidities, medication use, tobacco smoking, reasons for admission, and 30-day mortality...
2018: PloS One
https://www.readbyqxmd.com/read/29658619/prevalence-of-risk-factors-for-noncommunicable-diseases-in-adults-key-findings-from-the-pakistan-steps-survey
#11
Ibrar Rafique, Muhammad A N Saqib, Muhammad A Munir, Huma Qureshi, Rizwanullah, Shahzad A Khan, Heba Fouad
Background: Pakistan lacks data on the prevalence of risk factors for common noncommunicable diseases (NCDs). Objectives: This study aimed to determine the prevalence of risk factors for NCDs among a population-based sample in Punjab and Sindh provinces, Pakistan. Methods: This study was conducted in 2013-2014. The NCD risk factors examined were: current daily smoking, eating fewer than 5 servings of fruits/vegetable a day, low physical activity, overweight and obesity...
April 5, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29657442/obesity-is-associated-with-higher-complication-rates-in-revision-total-hip-arthroplasty
#12
John W Kennedy, David Young, Dominic R M Meek, Sanjeev R Patil
We examined differences in complication rates between obese and non-obese patients undergoing revision total hip arthroplasty. Sixty-five patients with a BMI ≥30 kg/m2 and 54 patients with a BMI of <30 kg/m2 were identified. Obese patients were 2.5 times more likely to suffer a complication than non-obese (38.4% cf 14.8%, p = 0.02). Obese patients were more likely to experience dislocation, leg length discrepancy, fracture, implant loosening, infection and pulmonary embolus. The obese group had a significantly higher revision rate (12...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656595/pathways-of-association-from-stress-to-obesity-in-early-childhood
#13
REVIEW
Alison L Miller, Julie C Lumeng
OBJECTIVE: The objective of this study is to critically review the literature on early life stress in relation to obesity in humans, including the multiple biological and behavioral mechanisms through which early life stress exposure (birth to the age of 5 years) may associate with obesity risk during childhood. METHODS: A review of the literature was conducted to identify studies on associations between early childhood stress and risk for obesity and the mechanisms of association...
April 14, 2018: Obesity
https://www.readbyqxmd.com/read/29656036/laparoscopic-adjustable-gastric-banding-in-adolescents-with-severe-obesity-psychological-aspects-decision-makers-of-surgery-and-2-year-outcomes-a-case-series
#14
E Riquin, F Schmitt, N Bouhours-Nouet, M Beaumesnil, M Dinomais, J Malka, M Robin, R Coutant, P Duverger
BACKGROUND: The results of medical treatment of severe obesity in the adolescent population (balanced diet and physical activity) are often unsatisfactory, and bariatric surgery is questioned. The psychological determinants for requesting bariatric surgery in these adolescents are unclear. The objective of this study was to report the psychiatric and psychological aspects as well as the determinants of the medical decision for surgery in a cohort of obese adolescents requesting bariatric surgery by laparoscopic adjustable gastric banding...
April 11, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#15
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655778/self-reported-weight-and-predictors-of-missing-responses-in-youth
#16
Magaly Aceves-Martins, Ross Whitehead, Jo Inchley, Montse Giralt, Candace Currie, Rosa Solà
OBJECTIVE: The aims of the present manuscript are to analyse self-reported data on weight, including the missing data, from the 2014 Scottish Health Behaviour in School-Aged Children (HBSC) Study, and to investigate whether behavioural factors related with overweight and obesity, namely dietary habits, physical activity and sedentary behaviour, are associated with weight non-response. RESEARCH METHODS & PROCEDURES: 10839 11-, 13- and 15-year-olds participated in the cross-national 2014 Scottish HBSC Study...
February 12, 2018: Nutrition
https://www.readbyqxmd.com/read/29655497/the-aahks-clinical-research-award-intraosseous-regional-prophylaxis-provides-higher-tissue-concentrations-in-high-bmi-patients-in-total-knee-arthroplasty-a-randomized-trial
#17
Seung Joon Chin, Grant A Moore, Mei Zhang, Henry D Clarke, Mark J Spangehl, Simon W Young
BACKGROUND: Obesity is an established risk factor for periprosthetic joint infections after total knee arthroplasty (TKA). In obese patients, a larger dose of prophylactic vancomycin based on actual body weight is required to reach therapeutic concentrations. It is unclear how tissue concentrations are affected when intraosseous regional administration (IORA) is used in this population. This study compared tissue concentrations of low-dose vancomycin via IORA vs actual body weight-adjusted systemic intravenous (IV) dose in primary TKA...
March 15, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29653185/sex-differences-in-the-development-of-hepatic-steatosis-in-cafeteria-diet-induced-obesity-in-young-mice
#18
Fabiana Rodrigues Silva Gasparin, Fernando Olinto Carreño, Juliana Moraes Mewes, Eduardo Hideo Gilglioni, Clairce Luzia Salgueiro Pagadigorria, Maria Raquel Marçal Natali, Karina Sayuri Utsunomiya, Rodrigo Polimeni Constantin, Amanda Tomie Ouchida, Carlos Curti, Ingrid C Gaemers, Ronald Petrus Johannes Oude Elferink, Jorgete Constantin, Emy Luiza Ishii-Iwamoto
The present study was planned to improve our understanding about sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. Female (FCaf) and male (MCaf) mice fed a cafeteria diet had similar body weight gain and adiposity index, but FCaf had a more extensive steatosis than MCaf. FCaf livers exhibited a higher non-alcoholic fatty liver disease activity score, elevated lipid percentage area (+34%) in Sudan III staining and increased TG content (+25%) compared to MCaf...
April 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29651819/biochemical-predictors-of-early-onset-non-alcoholic-fatty-liver-disease-in-young-children-with-obesity
#19
Ju Young Kim, Jinmin Cho, Hye Ran Yang
BACKGROUND: The prevalence of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) and their associated risk factors are not well-established in young children with obesity. The purpose of this study was to evaluate the prevalence of early onset NAFLD and identify its biochemical predictors in obese children aged less than 10 years. METHODS: Anthropometric measurements, blood pressure, laboratory tests, and abdominal ultrasonography (USG) were performed in all subjects...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29651648/body-mass-index-and-mortality-in-patients-with-gastric-cancer-a-large-cohort-study
#20
Jung Hwan Lee, Boram Park, Jungnam Joo, Myeong-Cherl Kook, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Soo-Jeong Cho
BACKGROUND: The effects of obesity on prognosis in gastric cancer are controversial. AIMS: To evaluate the association between body mass index (BMI) and mortality in patients with gastric cancer. METHODS: A single-institution cohort of 7765 patients with gastric cancer undergoing curative gastrectomy between October 2000 and June 2016 was categorized into six groups based on BMI: underweight (< 18.5 kg/m2 ), normal (18.5 to < 23 kg/m2 ), overweight (23 to < 25 kg/m2 ), mildly obese (25 to < 28 kg/m2 ), moderately obese (28 to < 30 kg/m2 ), and severely obese (≥ 30 kg/m2 )...
April 12, 2018: Gastric Cancer
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