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https://www.readbyqxmd.com/read/29232526/prevention-of-childhood-obesity-in-child-health-services-follow-up-of-the-primrose-trial
#1
Johanna Enö Persson, Benjamin Bohman, Per Tynelius, Finn Rasmussen, Ata Ghaderi
BACKGROUND: Childhood obesity is an urgent public health concern, and there's a need for long-term, high-quality, primary prevention trials targeting parents of young children. The aim of the current study was to evaluate the long-term effect of a parental support program based on motivational interviewing (MI). METHODS: A cluster randomized controlled trial was carried out in eight Swedish counties. Participating families (N = 1355) were enrolled when the child was 9 months old, and participated in nine sessions during ∼39 months...
December 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29230947/dietary-slowly-digestible-starch-triggers-the-gut-brain-axis-in-obese-rats-with-accompanied-reduced-food-intake
#2
Like Y Hasek, Robert J Phillips, Genyi Zhang, Kimberly P Kinzig, Choon Young Kim, Terry L Powley, Bruce R Hamaker
SCOPE: Slowly digestible starch (SDS), as a functional carbohydrate providing a slow and sustained glucose release, may be able to modulate food intake through activation of the gut-brain axis. METHODS AND RESULTS: Diet-induced obese rats were used to test the effect on feeding behavior of high fat (HF) diets containing a SDS, fabricated to digest into the ileum, as compared to rapidly digestible starch (RDS). Ingestion of the HF-SDS diet over an 11-week period reduced daily food intake, through smaller meal size, to the same level as a lean body control group, while the group consuming the HF-RDS diet remained at a high food intake...
December 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29229888/the-association-between-body-mass-index-and-frequency-of-emergency-department-visits-and-hospitalization-for-asthma-exacerbation-in-a-pediatric-population
#3
Ghadah Abdulrahman Alhekail, Alaa Althubaiti, Sulaiman AlQueflie
BACKGROUND: The prevalence of both asthma and obesity are increasing. Although some studies suggest an association between body mass index (BMI) and frequency of emergency department (ED) visits and hospitalization for asthma exacerbation, any association remains unproven. OBJECTIVE: Estimate the frequency of asthma exacerbation in obese children, and identify any relationship between BMI and frequency of ED visits and hospitalization for asthma exacerbation. DESIGN: Retrospective review of medical records...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229660/rationale-and-design-of-geneius-a-prospective-observational-study-on-the-genetic-and-environmental-determinants-of-body-mass-index-evolution-in-canadian-undergraduate-students
#4
Rita E Morassut, Christine Langlois, Akram Alyass, Adeola F Ishola, Fereshteh T Yazdi, Alexandra J Mayhew, Hudson Reddon, James MacKillop, Marie Pigeyre, David Meyre
INTRODUCTION: Obesity is a global epidemic and is a risk factor for developing other comorbidities. Young adulthood is a critical period for body weight change and establishing healthy lifestyle behaviours. The 'Freshman 15' suggests that undergraduate students gain 15 lbs (6.8 kg) during their first year of university, although evidence estimates a more modest weight gain of approximately 3-5 lbs (1.4-2.3 kg). Previous studies have only investigated weight change in the first year and do not study potential risk factors...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29225439/exploring-the-obesity-paradox-as-a-correlate-of-cognitive-and-physical-function-in-community-dwelling-black-and-white-older-adults
#5
Jeannine S Skinner, Willie Mae Abel, Katryna McCoy, Consuelo H Wilkins
Objective: The obesity paradox has been documented in aged populations, yet it remains unclear if this paradox persists for physical and cognitive outcomes in community-dwelling older adult populations. Our study examines associations between body mass index (BMI) classification, cognitive function, and physical function. We also investigate whether these associations are modified by race or age. Design: Cross-sectional study. Setting: Senior residential sites and community centers in Saint Louis, Missouri...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29223856/modulation-of-glutathione-peroxidase-activity-by-age-dependent-carbonylation-in-glomeruli-of-diabetic-mice
#6
Tanja Wiedenmann, Nadine Dietrich, Thomas Fleming, Sandro Altamura, Leo E Deelman, Rob H Henning, Martina U Muckenthaler, Peter P Nawroth, Hans-Peter Hammes, Andreas H Wagner, Markus Hecker
AIMS: Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions. Here we studied the influence of age-dependent protein carbonylation on expression and activity of the anti-oxidative selenoenzyme glutathione peroxidase (GPx) in insulin-deficient Ins2Akita mice and type 2 diabetic obese db/db mice in context of diabetic nephropathy. METHODS: Protein carbonylation, GPx expression and activity were examined in kidney tissue and lysates by common histological and protein biochemical methods...
November 22, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29222051/long-term-fermented-soybean-paste-improves-metabolic-parameters-associated-with-non-alcoholic-fatty-liver-disease-and-insulin-resistance-in-high-fat-diet-induced-obese-mice
#7
Min-Seok Kim, Bobae Kim, Haryung Park, Yosep Ji, Wilhelm Holzapfel, Do-Young Kim, Chang-Kee Hyun
Recently, Korean traditional fermented soybean paste, called Doenjang, has attracted attention for its protective effect against diet-related chronic diseases such as obesity and type 2 diabetes. Long-term fermented soybean pastes (LFSPs) are made by fermentation with naturally-occurring microorganisms for several months, whereas short-term fermented soybean pastes (SFSPs) are produced by shorter-time fermentation inoculated with a starter culture. Here, we demonstrate that administration of LFSP, but not SFSP, protects high-fat diet (HFD)-fed obese mice against non-alcohol fatty liver disease (NAFLD) and insulin resistance...
December 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29220530/impaired-lipolysis-diminished-fat-oxidation-and-metabolic-inflexibility-in-obese-girls-with-polycystic-ovary-syndrome
#8
Joon Young Kim, Hala Tfayli, Sara F Michaliszyn, Silva Arslanian
CONTEXT: Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (RQ). Despite insulin resistance in glucose metabolism in PCOS women and adolescents, little is known about adipose tissue metabolism and metabolic flexibility. OBJECTIVE: To investigate whole-body lipolysis, substrate oxidation and metabolic flexibility in obese PCOS vs. non-PCOS girls. PATIENTS/DESIGN: Twenty-one obese (BMI 32...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29217318/ghrh-plus-arginine-and-arginine-administration-evokes-the-same-ratio-of-gh-isoforms-levels-in-young-patients-with-prader-willi-syndrome
#9
Antonello E Rigamonti, Antonino Crinò, Sarah Bocchini, Alessio Convertino, Martin Bidlingmaier, Michael Haenelt, Sofia Tamini, Silvano G Cella, Graziano Grugni, Alessandro Sartorio
Human GH is present in pituitary and circulation as several isoforms, the prevalent being 22kDa- and 20kDa-GH. Recently, we have demonstrated the preservation of a normal balance in GH isoforms after GH releasing hormone (GHRH) plus arginine (ARG) administration in adult patients with Prader-Willi syndrome (PWS), one of the most common causes of syndromic obesity, often associated with GH deficiency (GHD). Aim of the present study was to measure circulating levels of 22kDa- and 20kDa-GH in young PWS patients (n=24; F/M: 10/14; genotype UPD/DEL/met+: 11/11/2; age: 10...
November 27, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29216853/obesity-associates-with-vasomotor-symptoms-in-postmenopause-but-with-physical-symptoms-in-perimenopause-a-cross-sectional-study
#10
Seul Koo, Younjhin Ahn, Joong-Yeon Lim, Juhee Cho, Hyun-Young Park
BACKGROUND: Middle-aged women experience various menopausal symptoms during the menopause. These symptoms can affect their quality of life and health. Several epidemiological studies reported that obesity associates with menopausal symptoms. The aim of this cross-sectional study was to examine the associations between obesity and multiple menopausal symptoms at different stages of menopause in middle-aged Korean women. METHODS: The study population included women aged 44-56 years who visited a tertiary referral hospital for medical check-ups between November 2012 and March 2013 and were free from serious illness, could comprehend a questionnaire...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29214777/is-there-a-sex-related-difference-in-the-obesity-paradox-in-systolic-heart-failure-sex-related-difference-in-the-obesity-paradox
#11
Soonchang Hong, Ji Hyun Lee, Kyung Min Kim, Jun Won Lee, Young Jin Youn, Min Soo Ahn, Sung Gyun Ahn, Seung Hwan Lee, Junghan Yoon, Kyung Hoon Choe, Byung Su Yoo
PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29213285/low-levels-of-sex-hormone-binding-globulin-constitute-an-independent-risk-factor-for-arterial-stiffness-in-korean-women
#12
Kunhee Han, Hyejin Chun, Moon-Jong Kim, Doo-Yeoun Cho, Soo-Hyun Lee, Bo Youn Won, Kwang-Min Kim, Nam-Seok Joo, Young-Sang Kim
The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29212858/decreased-edhf-mediated-relaxation-is-a-major-mechanism-in-endothelial-dysfunction-in-resistance-arteries-in-aged-mice-on-prolonged-high-fat-sucrose-diet
#13
Shannon M Dunn, Kumuda C Das
High-fat sucrose (HFS) diet in aged individuals causes severe weight gain (obesity) with much higher risk of cardiovascular diseases such as hypertension or atherosclerosis. Endothelial dysfunction is a major contributor for these vascular disorders. We hypothesize that prolonged ingestion of HFS diet by aged mice would accentuate endothelial dysfunction in the small resistance arteries. Male C57BL/6J mice at 12 weeks of age were divided into four groups and fed either normal chow (NC) or high-fat sucrose diet (HFS)...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29212268/comp-angiopoietin-1-mitigates-changes-in-lipid-droplet-size-macrophage-infiltration-of-adipose-tissue-and-renal-inflammation-in-streptozotocin-induced-diabetic-mice
#14
Yu Jin Jung, Woong Park, Tung Nguyen-Thanh, Kyung Pyo Kang, Heung Young Jin, Suhn Hee Kim, Wonhee Suh, Won Kim
Adipose tissue is considered to be an endocrine organ, and adipocyte size correlates with insulin resistance and metabolic parameters in obesity. There is little data on the effects of angiopoietin-1 in adipose tissue and kidney in streptozotocin (STZ)-induced diabetes. In this study, we investigated the protective effect of COMP-angiopoietin-1 (COMP-Ang1), a potent variant of angiopoietin-1, on vascular endothelial cells in epididymal adipose tissue and its regulatory effect on other metabolic parameters, such as lipid droplet diameter, macrophage infiltration, and renal inflammation in STZ-treated mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209384/association-between-healthcare-utilization-and-depression-in-korean-women-with-cardiovascular-conditions
#15
Se Jin Park, Jung Won Jang, Ah Young Kim, Seungyeon Hong, Boram Yuk, Ye Won Min, Kyung A Park, Subin Park
Objective: This study aimed to examine the associations between depression and both coronary artery disease (CAD) and cardiovascular risk factors (CVRs) in Korean women. Furthermore, this study sought to determine whether depression was associated with use of healthcare services in women with CAD or CVRs. Methods: This cross-sectional study was conducted on 26,335 women who were aged 19 years or older, and who participated in the Korean National Health and Nutrition Examination Survey (2007-2014)...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29208554/intracutaneous-delivery-of-gelatins-induces-lipolysis-and-suppresses-lipogenesis-of-adipocytes
#16
Sung-Min An, Keum-Yong Seong, Sang-Gu Yim, Young Jun Hwang, Seong Hwan Bae, Seung Yun Yang, Beum-Soo An
Due to growing interest in cosmetics and medical applications, therapeutic medications that reduce the amount of local subcutaneous adipose tissue have potential for obesity treatment. However, conventional methods such as surgical operation are restricted due to risk of complications. Here, we report a simple and effective method for local reduction of subcutaneous adipose tissue (AT) by using microneedle-assisted transdermal delivery of natural polymers. After in vitro screening tests, gelatin was selected as a therapeutic polymer to reduce accumulation of AT...
December 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29206648/relationship-between-plasma-protein-s-levels-and-apolipoprotein-c-ii-in-japanese-middle-aged-obese-women-and-young-nonobese-women
#17
Yukiko Otsuka, Maiko Ueda, Eri Nakazono, Tomohide Tsuda, Xiuri Jin, Kenta Noguchi, Shihoko Sata, Hitomi Miyazaki, Shimako Abe, Katsumi Imai, Masako Iwamoto, Takashi Masuda, Ririko Moriguchi, Shuji Nakano, Hiroko Tsuda
: Protein S, a nonenzymatic cofactor to activated protein C, presents in two forms in plasma, free form and in a complex with C4b-binding protein. The aim of this study was to determine the association of plasma protein S levels with the variables related to cardiovascular disease risk. The relationships between plasma protein S levels with lipids, inflammation markers, and adiposity were first examined on middle-aged obese women (n = 62), then on young nonobese women (n = 160) to verify the findings in the obese women...
December 4, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29206210/immortalization-of-porcine-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-transgenic-liver-cells-using-sv40-large-t-antigen
#18
Hee Young Kang, Young-Kwon Choi, Yeon Ik Jeong, Kyung-Chul Choi, Sang-Hwan Hyun, Woo-Suk Hwang, Eui-Bae Jeung
Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG) fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29203751/-metabolic-syndrome-a-new-look-at-a-known-problem
#19
Sylwia Płaczkowska, Lilla Pawlik-Sobecka, Izabela Kokot, Agnieszka Piwowar
Civilization changes over the past decades have been associated with an increase in the incidence of various metabolic disorders, especially in the carbohydrate-lipid metabolism, which are not always associated with obesity. Metabolic syndrome, despite changing criteria of recognition, is a clinically established risk factor for civilization diseases development. On the other side, the incidence of complex metabolic disorders in non-obese people is increasing, which is referred to in the literature as metabolic obesity with normal body mass...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29199868/entry-body-mass-and-earnings-once-penalized-ever-penalized
#20
Tae Hyun Kim, Euna Han
It has previously been reported that an individual's body mass index (BMI) contemporaneously penalizes wages for women, but has no effect and sometimes rewards wages for men. In young adults, we estimate the association of BMI status with initial wages to assess whether initial BMI at the beginning of an individual's career affects initial and later earnings. We pooled data from 388 men and 305 women, aged 20-40 years, with BMI information for the first year of employment, using the Korean Labor and Income Panel Study...
2017: Biodemography and Social Biology
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