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https://www.readbyqxmd.com/read/28109285/korean-mistletoe-viscum-album-coloratum-extract-regulates-gene-expression-related-to-muscle-atrophy-and-muscle-hypertrophy
#1
Juseong Jeong, Choon-Ho Park, Inbo Kim, Young-Ho Kim, Jae-Min Yoon, Kwang-Soo Kim, Jong-Bae Kim
BACKGROUND: Korean mistletoe (Viscum album coloratum) is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions, being implicated in having anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. Recently, we also reported that Korean mistletoe extract (KME) improves endurance exercise in mice, suggesting its beneficial roles in enhancing the capacity of skeletal muscle. METHODS: We examined the expression pattern of several genes concerned with muscle physiology in C2C12 myotubes cells to identify whether KME inhibits muscle atrophy or promotes muscle hypertrophy...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28106613/relationship-of-sleep-duration-and-regularity-with-dietary-intake-among-preschool-aged-children-with-obesity-from-low-income-families
#2
Megan E Petrov, Kiley B Vander Wyst, Corrie M Whisner, Mihyun Jeong, Michaela Denniston, Michael W Moramarco, Martina R Gallagher, Elizabeth Reifsnider
OBJECTIVE: Diet is a modifiable factor associated with pediatric obesity outcomes, but few studies have evaluated the relationships of sleep duration and regularity on dietary intake of young preschool-aged children. The goal of this study was to evaluate whether short sleep duration and irregular sleep timing were associated with greater calorie, carbohydrate and fat consumption among young children with obesity from low-income families. METHODS: Fifty-one ethnically diverse children aged 2 to 4 years were recruited from the Special Supplemental Nutrition Program for Women, Infants, and Children clinics in a southeast Texas county...
January 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28106509/potential-epigenetic-biomarkers-of-obesity-related-insulin-resistance-in-human-whole-blood
#3
Samantha E Day, Richard L Coletta, Joon Young Kim, Luis A Garcia, Latoya E Campbell, Tonya R Benjamin, Lori R Roust, Elena A De Filippis, Lawrence J Mandarino, Dawn K Coletta
Obesity can increase the risk of complex metabolic diseases, including insulin resistance. Moreover, obesity can be caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are not well defined. Therefore, the identification of novel epigenetic biomarkers of obesity allows for a more complete understanding of the disease and its underlying insulin resistance. The aim of our study was to identify DNA methylation changes in whole-blood that were strongly associated with obesity and insulin resistance...
January 20, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28103626/nonalcoholic-fatty-liver-disease-in-adolescents-and-young-adults-the-next-frontier-in-the-epidemic
#4
REVIEW
Iliana Doycheva, Kymberly D Watt, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is a significant health burden in adolescents and young adults (AYAs) with substantial rise in prevalence over the last decades. This parallels high rates of obesity and metabolic syndrome in this age group, with unhealthy lifestyle also playing an independent role. Genetic factors, gender, and ethnicity should be considered in a risk stratification model. NAFLD and nonalcoholic steatohepatitis (NASH) in AYAs often go unrecognized and if untreated, can progress eventually to cirrhosis requiring liver transplantation before the age of 40...
January 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28102434/low-muscle-mass-and-risk-of-type-2-diabetes-in-middle-aged-and-older-adults-findings-from-the-koges
#5
Jang Won Son, Seong Su Lee, Sung Rae Kim, Soon Jib Yoo, Bong Yun Cha, Ho Young Son, Nam H Cho
AIMS/HYPOTHESIS: Asians have a propensity to develop type 2 diabetes with a lower BMI than Western populations. This discrepancy may be due to differences in body fat and muscle mass for a given BMI. However, unlike adiposity, it is unclear whether muscle mass affects the risk of type 2 diabetes in Asian populations. METHODS: We conducted a 2-yearly prospective assessment of 6895 participants who were free of diabetes at the baseline examination as part of the Korean Genome Epidemiology Study...
January 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28098516/germacrone-attenuates-hyperlipidemia-and-improves-lipid-metabolism-in-high-fat-diet-induced-obese-c57bl-6j-mice
#6
Yuan-Ri Guo, Se-Young Choung
We previously showed that Aster spathulifolius Maxim extract (ASE) reduced body weight gain and serum and liver lipid levels and significantly suppressed serum insulin and leptin concentrations in high-fat diet (HFD)-induced obese rats. Germacrone (GM) was identified as a potent bioactive constituent of ASE. In this study, we hypothesized that GM can attenuate hyperlipidemia by alleviating fatty acid (FA) synthesis/uptake and improve lipid metabolism by stimulating FA β-oxidation in HFD-induced obese C57BL/6J mice...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28096874/prevalence-of-metabolic-syndrome-in-patients-with-schizophrenia-in-korea-a-multicenter-nationwide-cross-sectional-study
#7
Jung Sun Lee, Jun Soo Kwon, Daeho Kim, Sung-Wan Kim, Jae-Jin Kim, Jong-Hoon Kim, Hee Jung Nam, Seunghyong Ryu, Il Ho Park, Suk Kyoon An, Hong-Seok Oh, Seunghee Won, Kanguk Lee, Kyu Young Lee, Seung-Hwan Lee, Yu Sang Lee, Jung-Seo Yi, Kyung Sue Hong, Yeon Ho Joo
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28096235/role-of-cardiotrophin-1-in-the-regulation-of-metabolic-circadian-rhythms-and-adipose-core-clock-genes-in-mice-and-characterization-of-24-h-circulating-ct-1-profiles-in-normal-weight-and-overweight-obese-subjects
#8
Miguel López-Yoldi, Kimber L Stanhope, Marta Garaulet, X Guoxia Chen, Beatriz Marcos-Gómez, María Paz Carrasco-Benso, Eva M Santa Maria, Xavier Escoté, Vivien Lee, Marinelle V Nunez, Valentina Medici, Eduardo Martínez-Ansó, Neira Sáinz, Ana E Huerta, Laura M Laiglesia, Jesús Prieto, J Alfredo Martínez, Matilde Bustos, Peter J Havel, Maria J Moreno-Aliaga
Cardiotrophin (CT)-1 is a regulator of glucose and lipid homeostasis. In the present study, we analyzed whether CT-1 also acts to peripherally regulate metabolic rhythms and adipose tissue core clock genes in mice. Moreover, the circadian pattern of plasma CT-1 levels was evaluated in normal-weight and overweight subjects. The circadian rhythmicity of oxygen consumption rate (Vo2) was disrupted in aged-obese CT-1-deficient (CT-1(-/-)) mice (12 mo). Although circadian rhythms of Vo2 were conserved in young-lean CT-1(-/-) mice (2 mo), CT-1 deficiency caused a phase shift of the acrophase...
January 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28096054/glycogen-storage-disease-type-ia-mice-with-less-than-2-of-normal-hepatic-glucose-6-phosphatase-%C3%AE-activity-restored-are-at-risk-of-developing-hepatic-tumors
#9
Goo-Young Kim, Young Mok Lee, Joon Hyun Kwon, Jun-Ho Cho, Chi-Jiunn Pan, Matthew F Starost, Brian C Mansfield, Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA) and carcinoma (HCC), is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC). We have previously shown that G6pc-/- mice receiving gene transfer mediated by rAAV-G6PC, a recombinant adeno-associated virus (rAAV) vector expressing G6Pase-α, and expressing 3-63% of normal hepatic G6Pase-α activity maintain glucose homeostasis and do not develop HCA/HCC. However, the threshold of hepatic G6Pase-α activity required to prevent tumor formation remained unknown...
January 10, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28095509/body-mass-index-at-accession-and-incident-cardiometabolic-risk-factors-in-us-army-soldiers-2001-2011
#10
Adela Hruby, Lakmini Bulathsinhala, Craig J McKinnon, Owen T Hill, Scott J Montain, Andrew J Young, Tracey J Smith
Individuals entering US Army service are generally young and healthy, but many are overweight, which may impact cardiometabolic risk despite physical activity and fitness requirements. This analysis examines the association between Soldiers' BMI at accession and incident cardiometabolic risk factors (CRF) using longitudinal data from 731,014 Soldiers (17.0% female; age: 21.6 [3.9] years; BMI: 24.7 [3.8] kg/m2) who were assessed at Army accession, 2001-2011. CRF were defined as incident diagnoses through 2011, by ICD-9 code, of metabolic syndrome, glucose/insulin disorder, hypertension, dyslipidemia, or overweight/obesity (in those not initially overweight/obese)...
2017: PloS One
https://www.readbyqxmd.com/read/28094877/hypothalamus-specific-re-introduction-of-snord116-into-otherwise-snord116-deficient-mice-increased-energy-expenditure
#11
Y Qi, L Purtell, M Fu, L Zhang, S Zolotukhin, L Campbell, H Herzog
The Snord116 gene cluster has been recognized as a critical contributor to the Prader-Willi Syndrome (PWS) with mice lacking Snord116 displaying many classical PWS phenotypes including low postnatal body weight, reduced bone mass and increased food intake. However, these mice do not develop obesity due to increased energy expenditure. To understand the physiological function of Snord116 better and potentially rescue the altered metabolism of Snord116(-/-) mice, we used an adeno-associated viral (AAV) approach to reintroduce the Snord116 gene product into the hypothalamus in Snord116(-/-) mice at different ages...
January 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28093873/diagnostic-and-management-challenges-from-childhood-puberty-through-to-transition-in-severe-insulin-resistance-due-to-insulin-receptor-mutations
#12
Christina Wei, Christine P Burren
Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15.3 mg/L) and heterozygous p.Pro1205Leu mutation in the INSR gene encoding the insulin receptor. She experienced postprandial hypoglycaemia on metformin; acarbose was trialled and discontinued aged 16 years, as she became normoglycaemic...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28093849/obesity-and-type-2-diabetes-are-associated-with-elevated-pcsk9-levels-in-young-women
#13
Amy E Levenson, Amy S Shah, Philip R Khoury, Thomas R Kimball, Elaine M Urbina, Sarah D de Ferranti, David M Maahs, Lawrence M Dolan, R Paul Wadwa, Sudha B Biddinger
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol and cardiovascular disease risk, and is an emerging therapeutic target. OBJECTIVE: We compared serum PCSK9 levels in young adults, with and without type 2 diabetes. SUBJECTS AND METHODS: Cross-sectional analysis was conducted in a cohort, aged 15 to 26 years, in Cincinnati, OH, from 2005 to 2010. Serum PCSK9 levels were measured in 94 youth with type 2 diabetes, 93 obese control subjects, and 99 lean control subjects...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28092931/the-criteria-of-metabolic-syndrome-and-national-health-checkup-and-education-system-in-japan
#14
Kazumasa Yamagishi, Hiroyasu Iso
Two major definitions of metabolic syndrome have been proposed. One focuses on accumulation of risk factors such as the American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) criteria; and the other focuses on abdominal obesity such as the International Diabetes Federation (IDF) and Japanese criteria. The latter consider waist circumference as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA and the other organizations attempted to unify these criteria, and waist circumference is no longer an obligatory component...
January 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28090739/obesity-related-genetic-polymorphisms-and-adiposity-indices-in-a-young-italian-population
#15
Laura Bordoni, Francesca Marchegiani, Marco Piangerelli, Valerio Napolioni, Rosita Gabbianelli
Pediatric obesity develops when a complex biological predisposition collides with an obesogenic environment. To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR). We also tested the combinations of identified risk genotypes and epistatic interactions among them to determine the existence of cumulative effects in predicting the predisposition to gain weight...
January 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28090470/acanthosis-nigricans-as-a-clinical-predictor-of-insulin-resistance-in-obese-children
#16
Young Kwon Koh, Jae Hee Lee, Eun Young Kim, Kyung Rye Moon
PURPOSE: This study aimed to evaluate the utility of acanthosis nigricans (AN) severity as an index for predicting insulin resistance in obese children. METHODS: The subjects comprised 74 obese pediatric patients who attended the Department of Pediatrics at Chosun University Hospital between January 2013 and March 2016. Waist circumference; body mass index; blood pressure; fasting glucose and fasting insulin levels; lipid profile; aspartate transaminase, alanine transaminase, glycated hemoglobin, C-peptide, and uric acid levels; and homeostatic model assessment insulin resistance (HOMA-IR) and quantitative insulin check sensitivity index (QUICKI) scores were compared between subjects with AN and those without AN...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28090227/symptomatic-gallstones-in-the-young-changing-trends-of-the-gallstone-disease-related-hospitalization-in-the-state-of-new-york-1996-2010
#17
Sridhar Chilimuri, Vinaya Gaduputi, Hassan Tariq, Suresh Nayudu, Trupti Vakde, Mariela Glandt, Harish Patel
BACKGROUND: The aim of the study was to evaluate if the gallstone-related hospitalizations in the young (< 20 years of age) have increased over time in both the Bronx County and New York State as a whole. METHODS: We retrospectively reviewed 15 years (1996 - 2010) of Statewide Planning and Research Cooperative System (SPARCS) data of New York State Department of Health. Patients with ICD-9 code diagnosis of 574 (cholelithiasis) among the first three discharge diagnoses were reviewed...
February 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28090039/interaction-between-the-rgs6-gene-and-psychosocial-stress-on-obesity-related-traits
#18
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min
Obesity is a major risk factor for chronic diseases and arises from the interactions between environmental factors and multiple genes. Psychosocial stress may affect the risk for obesity, modifying food intake and choice. A recent study suggested regulator of G-protein signaling 6 (RGS6) as a novel candidate gene for obesity in terms of reward-related feeding under stress. In this study, we tried to verify the unidentified connection between RGS6 and human obesity with psychosocial stress in a Korean population...
January 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28089924/water-juice-or-soda-mothers-and-grandmothers-of-preschoolers-discuss-the-acceptability-and-accessibility-of-beverages
#19
Karin Eli, Agneta Hörnell, Mahnoush Etminan Malek, Paulina Nowicka
Intake of sugary beverages is strongly associated with weight gain and obesity among children; however, differences between mothers' and grandmothers' attitudes and practices concerning young children's beverage consumption remain unclear. This is notable since about a quarter of families in the US and the UK rely on grandparents as the main providers of informal childcare. The aim of this study is to examine mothers' and maternal grandmothers' attitudes, knowledge, and practices regarding preschool-age children's beverage consumption...
January 12, 2017: Appetite
https://www.readbyqxmd.com/read/28089789/differing-clinical-characteristics-between-young-and-older-patients-presenting-with-myocardial-infarction
#20
Kyriakos Matsis, Ana Holley, Ali Al-Sinan, Phillip Matsis, Peter D Larsen, Scott A Harding
BACKGROUND: To date, there has been no detailed study of the risk factors and clinical characteristics of patients presenting with myocardial infarction (MI) at a young age in our region. The purpose of this study was to assess the rate and clinical profile of those presenting with young MI in New Zealand. METHODS: We identified a cohort of 1199 patients presenting with acute MI between January 2012 and November 2015 from the Wellington Acute Coronary Syndrome Registry...
November 11, 2016: Heart, Lung & Circulation
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