keyword
MENU ▼
Read by QxMD icon Read
search

succinate

keyword
https://www.readbyqxmd.com/read/29345466/flow-photochemistry-as-a-tool-for-the-total-synthesis-of-epigalcatin
#1
Kamil Lisiecki, Zbigniew Czarnocki
The first total synthesis of (+)-epigalcatin was completed in a highly stereoselective manner starting from piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate. l-Prolinol was used as a chiral auxiliary. The crucial step in this procedure involves the construction of the cyclolignan framework by continuous-flow photocyclization of a chiral atropisomeric 1,2-bisbenzylidenesuccinate amide ester.
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29343865/targeting-murine-leukemic-stem-cells-by-antibody-functionalized-mesoporous-silica-nanoparticles
#2
Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén, Christian Buske
Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short - term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342836/cool-climate-red-wines-chemical-composition-and-comparison-of-two-protocols-for-%C3%A2-h-nmr-analysis
#3
Violetta Aru, Klavs Martin Sørensen, Bekzod Khakimov, Torben Bo Toldam-Andersen, Søren Balling Engelsen
This study investigates the metabolome of 26 experimental cool-climate wines made from 22 grape varieties using two different protocols for wine analysis by proton nuclear magnetic resonance (¹H-NMR) spectroscopy. The wine samples were analyzed as-is (wet) and as dried samples. The NMR datasets were preprocessed by alignment and mean centering. No normalization or scaling was performed. The "wet" method preserved the inherent properties of the samples and provided a fast and effective overview of the molecular composition of the wines...
January 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342118/microbial-degradation-behavior-in-seawater-of-polyester-blends-containing-poly-3-hydroxybutyrate-co-3-hydroxyhexanoate-phbhhx
#4
Hitoshi Sashiwa, Ryuji Fukuda, Tetsuo Okura, Shunsuke Sato, Atsuyoshi Nakayama
The microbial degradation behavior of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and its compound with several polyesters such as poly(butylene adipate-co-telephtharate) (PBAT), poly(butylene succinate) (PBS), and polylactic acid (PLA) in seawater was tested by a biological oxygen demand (BOD) method. PHBHHx showed excellent biodegradation in seawater in this study. In addition, the biodegradation rate of several blends was much influenced by the weight ratio of PHBHHx in their blends and decreased in accordance with the decrement of PHBHHX ratio...
January 17, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29342099/poly-lactic-acid-pla-based-tear-resistant-and-biodegradable-flexible-films-by-blown-film-extrusion
#5
Norma Mallegni, Thanh Vu Phuong, Maria-Beatrice Coltelli, Patrizia Cinelli, Andrea Lazzeri
Poly(lactic acid) (PLA) was melt mixed in a laboratory extruder with poly(butylene adipate-co-terephthalate) (PBAT) and poly(butylene succinate) (PBS) in the presence of polypropylene glycol di glycidyl ether (EJ400) that acted as both plasticizer and compatibilizer. The process was then scaled up in a semi-industrial extruder preparing pellets having different content of a nucleating agent (LAK). All of the formulations could be processed by blowing extrusion and the obtained films showed mechanical properties dependent on the LAK content...
January 17, 2018: Materials
https://www.readbyqxmd.com/read/29341163/extent-of-surgery-for-phaeochromocytomas-in-the-genomic-era
#6
REVIEW
H M Rossitti, P Söderkvist, O Gimm
BACKGROUND: Germline mutations are present in 20-30 per cent of patients with phaeochromocytoma. For patients who develop bilateral disease, complete removal of both adrenal glands (total adrenalectomy) will result in lifelong adrenal insufficiency with an increased risk of death from adrenal crisis. Unilateral/bilateral adrenal-sparing surgery (subtotal adrenalectomy) offers preservation of cortical function and independence from steroids, but leaves the adrenal medulla in situ and thus at risk of developing new and possibly malignant disease...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29339836/the-role-of-metabolic-enzymes-in-mesenchymal-tumors-and-tumor-syndromes-genetics-pathology-and-molecular-mechanisms
#7
REVIEW
Inga-Marie Schaefer, Jason L Hornick, Judith V M G Bovée
The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur in enchondromas and chondrosarcomas in patients with the non-hereditary enchondromatosis syndromes Ollier disease and Maffucci syndrome and in sporadic tumors. IDH1/2 mutations result in excess production of the oncometabolite (D)-2-hydroxyglutarate...
January 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29338666/boosted-tca-cycle-enhances-survival-of-zebrafish-to-vibrio-alginolyticus-infection
#8
Man-Jun Yang, Zhi-Xue Cheng, Ming Jiang, Zao-Hai Zeng, Bo Peng, Xuan-Xian Peng, Hui Li
Vibrio alginolyticus is a waterborne pathogen that infects a wide variety of hosts including fish and human, and the outbreak of this pathogen can cause a huge economic loss in aquaculture. Thus, enhancing host's capability to survive from V. alginolyticus infection is key to fighting infection and this remains still unexplored. In the present study, we established a V. alginolyticus-zebrafish interaction model by which we explored how zebrafish survived from V. alginolyticus infection. We used GC-MS based metabolomic approaches to characterize differential metabolomes between survival and dying zebrafish upon infection...
January 17, 2018: Virulence
https://www.readbyqxmd.com/read/29337429/co-expression-of-orfcma-with-phb-depolymerase-phazcma-in-escherichia-coli-induces-efficient-whole-cell-biodegradation-of-polyesters
#9
Ming-Chieh Lee, En-Jung Liu, Cheng-Han Yang, Li-Jung Hsiao, Tzong-Ming Wu, Si-Yu Li
Whole-cell degradation of polyesters not only avoids the tedious process of enzyme separation, but also allows the degraded product to be reused as a carbon source. In this study, Escherichia coli BL21(DE3) harboring phaZCma , a gene encoding poly(3-hydroxybutyrate) (PHB) depolymerase from Caldimonas manganoxidans, was constructed. The extra-cellular fraction of E. coli/pPHAZ exhibited a fast PHB degradation rate where it only took 35 h to completely degrade PHB films, while C. manganoxidans took 81 h to do the same...
January 16, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29336527/sustainable-synthesis-of-oxalic-and-succinic-acid-via-aerobic-oxidation-of-c6-polyols-by-using-m-cnt-ncnt-m-fe-v-based-catalysts-in-mild-conditions
#10
Angela Dibenedetto, Maria Ventura, David Williamson, Francesco Lobefaro, Matthew D Jones, Davide Mattia, Francesco Nocito, Michele Aresta
Sustainable chemical industry encompasses the shift from fossil carbon to renewable carbon. The synthesis of chemicals from non-edible biomass (cellulosic or oily) represents one of the key steps for "greening" the chemical industry. In this paper we report the aerobic oxidation-cleavage of C6 polyols (5-HMF, glucose, fructose, sucrose) in water to oxalic acid-OA (and succinic acid-SA) under mild conditions using M@CNT/NCNT (M=Fe, V; CNT=carbon nanotubes; NCNT= N-doped CNT), which, under suitable conditions, are recoverable and reusable without any loss of efficiency...
January 16, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29330292/microenvironmental-derived-regulation-of-hif-signaling-drives-transcriptional-heterogeneity-in-glioblastoma-multiforme
#11
Dieter Henrik Heiland, Annette Gaebelein, Melanie Boerries, Jakob Woerner, Nils Pompe, Pamela Franco, Sabrina Heynckes, Mark D Bartholomä, Darren Ó hAilín, Maria Stella Carro, Marco Prinz, Stefan Weber, Irina Mader, Daniel Delev, Oliver Schnell
The evolving and highly heterogeneous nature of malignant brain tumors underlies their limited response to therapy and poor prognosis. In addition to genetic alterations, highly dynamic processes such as transcriptional and metabolic reprogramming play an important role in the development of tumor heterogeneity. The present study reports an adaptive mechanism in which the metabolic environment of malignant glioma drives transcriptional reprogramming. Multi-regional analysis of a glioblastoma patient biopsy revealed a metabolic landscape marked by varying stages of hypoxia and creatine enrichment...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29328042/dynamics-of-changes-in-indices-of-endogenous-intoxication-in-patients-with-acute-small-intestinal-obstruction-in-case-of-reamberin-use-in-the-comprehensive-treatment
#12
V Skrypko, A Kovalenko, E Talikova
The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29327126/antipyretic-effect-of-herba-ephedrae-ramulus-cinnamomi-herb-pair-on-yeast-induced-pyrexia-rats-a-metabolomics-study
#13
Xiao-Ming Wang, Wen-Jie Xu, Liang-Kui Xu, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the antipyretic mechanism of Herba Ephedrae (Eph)-Ramulus Cinnamomi (RC) herb pair on yeast-induced pyrexia in rats. METHODS: Totally 30 qualifified male SD rats were randomly assigned to the normal control (NC) group, the pyrexia model (model) group, the Eph, RC and Eph-RC treatment groups by a random digital table, 6 rats in each group. Each rat received a 20% aqueous suspension of yeast (10 mL/kg) except the NC group. The 3 treatment groups were administered 8...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29321642/profiling-of-metabolome-and-bacterial-community-dynamics-in-ensiled-medicago-sativa-inoculated-without-or-with-lactobacillus-plantarum-or-lactobacillus-buchneri
#14
X S Guo, W C Ke, W R Ding, L M Ding, D M Xu, W W Wang, P Zhang, F Y Yang
Using gas chromatography mass spectrometry and the PacBio single molecule with real-time sequencing technology (SMRT), we analyzed the detailed metabolomic profiles and microbial community dynamics involved in ensiled Medicago sativa (alfalfa) inoculated without or with the homofermenter Lactobacillus plantarum or heterofermenter Lactobacillus buchneri. Our results revealed that 280 substances and 102 different metabolites were present in ensiled alfalfa. Inoculation of L. buchneri led to remarkable up-accumulation in concentrations of 4-aminobutyric acid, some free amino acids, and polyols in ensiled alfalfa, whereas considerable down-accumulation in cadaverine and succinic acid were observed in L...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321189/gut-brain-signaling-in-energy-homeostasis-the-unexpected-role-of-microbiota-derived-succinate
#15
REVIEW
Filipe de Vadder, Gilles Mithieux
In the context of the obesity epidemic, dietary fibers that are found essentially in fruit and vegetables attract more and more attention, since they exert numerous metabolic benefits resulting in the moderation of body weight. Short-chain fatty acids, such as propionate and butyrate, produced through their fermentation by the intestinal microbiota, have long been thought to be the mediators of these benefits. In fact, propionate and butyrate were recently shown to activate intestinal gluconeogenesis, a function exerting metabolic benefits via its capacity of signaling to the brain by gastrointestinal nerves...
February 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29318897/in-vitro-and-in-silico-characterisation-of-lactobacillus-paraplantarum-d2-1-a-starter-culture-for-soymilk-fermentation
#16
Akihito Endo, Fuko Sasaki, Shintaro Maeno, Yu Kanesaki, Yu Hamaguchi, Glaezel Angelique Torres, Satoru Tomita, Junichi Nakagawa
Soymilk contains several functional nutrients and is thus a promising ingredient for production of functional foods. The present research aimed to study starter properties, functional characteristics and safety of Lactobacillus paraplantarum D2-1, a promising starter culture for soymilk fermentation. Strain D2-1 actively fermented soymilk within 24 h but had weak activity of additional acid production after 7 d. Succinate and acetoin, which could be linked to flavour and taste, were accumulated in fermented soymilk...
January 10, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29318721/catabolite-repression-in-campylobacter-jejuni-correlates-with-intracellular-succinate-levels
#17
Anne-Xander van der Stel, Chris H A van de Lest, Steven Huynh, Craig T Parker, Jos P van Putten, Marc M S M Wösten
Bacteria have evolved different mechanisms to catabolize carbon sources from nutrient mixtures. They first consume their preferred carbon source, before others are used. Regulatory mechanisms adapt the metabolism accordingly to maximize growth and to outcompete other organisms. The human pathogen Campylobacter jejuni is an asaccharolytic Gram-negative bacterium that catabolizes amino acids and organic acids for growth. It prefers serine and aspartate as carbon sources, however it lacks all regulators known to be involved in regulating carbon source utilization in other organisms...
January 10, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29318308/the-synthesis-of-7-substituted-2-3-dihydropyrido-4-3-d-pyridazine-1-4-diones-and-1-4-dioxo-7-substituted-1-2-3-4-tetrahydropyrido-4-3-d-pyridazine-6-oxides-from-methyl-ketones
#18
Benjamin Prek, Branko Stanovnik
A general four-step transformation of alkyl, cycloalkyl, aryl, and heteroaryl methyl ketones via 3-(dimethylamino)-1-substituted-prop-2-en-1-ones, followed by microwave [2+2] cycloaddition of dimethyl acetylenedicarboxylate, cyclization of (2E,3E)-2-[(dimethylamino)methylene]-3-(2-substituted)succinates with ammonia or hydroxylamine hydrochloride into 2-substituted-pyridine-4,5-dicarboxylates and their N-oxides and final cyclization with hydrazine hydrate into of 7-substituted-2,3-dihydropyrido[3,4-d]pyridazine-1,4-diones and 1,4-dioxo-7-substituted-1,2,3,4-tetrahydropyrido[4,3-d]pyridazine 6-oxides is shown...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29317344/redox-responsive-micelles-from-disulfide-bond-bridged-hyaluronic-acid-tocopherol-succinate-for-the-treatment-of-melanoma
#19
Junping Xia, Yunai Du, Liping Huang, Birendra Chaurasiya, Jiaheng Tu, Thomas J Webster, Chunmeng Sun
Nanotechnology-based chemotherapy is efficient in cancer treatment due to the targeted delivery of small molecules via nano-carriers, which are usually regarded as "inert". However, nano-materials are more preferred as carriers since many cause synergistic anti-tumor effects along with the drug cargo. In this study, a "bioactive" tocopherol succinate (TOS) was grafted to hyaluronic acid (HA) via of disulfide bonds to obtain HA-ss-TOS conjugates which can assemble into nano-micelles but dissociate when exposed to reducing environments in vitro and in vivo...
January 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29315239/mangiferin-accelerates-glycolysis-and-enhances-mitochondrial-bioenergetics
#20
Zhongbo Liu, Pasha Apontes, Ekaterina V Fomenko, Nan Chi, Victor L Schuster, Irwin J Kurland, Jeffrey E Pessin, Yuling Chi
One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by skeletal muscle, which can be exacerbated by chronic high caloric intake. Previously, we identified a natural compound, mangiferin (MGF) that improved glucose utilization in high fat diet (HFD)-induced insulin resistant mice. To further identify the molecular mechanisms of MGF action on glucose metabolism, we conducted targeted metabolomics and transcriptomics studies of glycolyic and mitochondrial bioenergetics pathways in skeletal muscle...
January 9, 2018: International Journal of Molecular Sciences
keyword
keyword
100287
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"