Na Wang, Feifei Ge, Cailian Cui, Yijing Li, Xiaowei Sun, Linlin Sun, Xinjuan Wang, Shuli Liu, Haolin Zhang, Yan Liu, Meng Jia, Mingda Yang
The prelimbic cortex (PL) and infralimbic cortex (IL) play a role in context-induced reinstatement of heroin seeking in an animal model of drug relapse. Both the PL and IL receive direct glutamatergic projections from the ventral CA1 (vCA1), which is also involved in context-induced reinstatement of cocaine and heroin seeking. Here we studied the role of vCA1-PL and vCA1-IL projections in context-induced reinstatement of heroin seeking by using electrophysiological, neuropharmacological, chemogenetic, and molecular methods...
November 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology