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ventral CA1

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https://www.readbyqxmd.com/read/28267433/hemi-ovariectomies-promote-a-decrease-in-the-dendritic-lengths-of-ca1-and-ca3-neurons-a-dimorphic-effect-of-the-cerebral-hemispheres
#1
Dolores Adriana Bravo Durán, Adriana Berenice Silva Gómez, Ana Coral Gutiérrez Rosas, Angélica Trujillo
Certain structures of the central nervous system (CNS) are morphologically and functionally related to the ovaries. Ovariectomy has been used to study the functional role of the ovaries in the CNS, as well as the role of the CNS on the reproductive system. In the present study, the effects of left and right hemi-ovariectomy on the morphology of pyramidal neurons from the CA1 and CA3 regions of the ventral hippocampus were studied. During the estrus phase, female Long-Evans rats underwent either left and right hemi-ovariectomies or left and right sham surgeries...
March 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28252602/-corticosterone-induced-changes-in-the-inhibitory-neurotransmission-in-hippocampal-ca1-synapses-depending-on-the-activity-of-inhibitory-synapses-that-express-cannabinoid-receptors
#2
E P Volkova, G G Nadareishvili, A P Bolshakov
AIM: To study an effect of corticosterone (100 nM) on spontaneous inhibitory postsynaptic currents (sIPSC) in pyramidal neurons of CA1 area and a role of inhibitory CB1-expressing synapses in the development of corticosterone-induced effects. MATERIAL AND METHODS: The experiments were performed on acute slices of the rat ventral hippocampus using whole-cell configuration of the patch-clamp technique. RESULTS AND CONCLUSION: The addition of corticosterone resulted in a small, but significant, increase in the frequency of sIPSCs during the first 10 minutes and then this parameter returned to the basal level...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28243162/segregated-cell-populations-enable-distinct-parallel-encoding-within-the-radial-axis-of-the-ca1-pyramidal-layer
#3
REVIEW
Tristan Geiller, Sebastien Royer, June-Seek Choi
Numerous studies have implicated the hippocampus in the encoding and storage of declarative and spatial memories. Several models have considered the hippocampus and its distinct subfields to contain homogeneous pyramidal cell populations. Yet, recent studies have led to a consensus that the dorso-ventral and proximo-distal axes have different connectivities and physiologies. The remaining deep-superficial axis of the pyramidal layer, however, remains relatively unexplored due to a lack of techniques that can record from neurons simultaneously at different depths...
February 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28218471/%C3%AE-4%C3%AE-%C3%AE-gabaa-receptors-in-dorsal-hippocampal-ca1-of-adolescent-female-rats-traffic-to-the-plasma-membrane-of-dendritic-spines-following-voluntary-exercise-and-contribute-to-protection-of-animals-from-activity-based-anorexia-through-localization-at-excitatory
#4
Chiye Aoki, Yi-Wen Chen, Tara Gunkali Chowdhury, Walter Piper
In hippocampal CA1 of adolescent female rodents, α4βδ-GABAA receptors (α4βδ-GABAA Rs) suppress excitability of pyramidal neurons through shunting inhibition at excitatory synapses. This contributes to anxiolysis of stressed animals. Socially isolated adolescent female rats with 8 days of wheel access, the last 4 days of which entail restricted food access, have been shown to exhibit excessive exercise, choosing to run instead of eat (activity-based anorexia [ABA]). Upregulation of α4βδ-GABAA Rs in the dorsal hippocampal CA1 (DH), seen among some ABA animals, correlates with suppression of excessive exercise...
February 20, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28218243/nmda-receptor-dependent-plasticity-in-the-bed-nucleus-of-the-stria-terminalis-triggers-long-term-anxiolysis
#5
Christelle Glangetas, Léma Massi, Giulia R Fois, Marion Jalabert, Delphine Girard, Marco Diana, Keisuke Yonehara, Botond Roska, Chun Xu, Andreas Lüthi, Stéphanie Caille, François Georges
Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSUB/CA1) inputs in regulating BNST activity at the single-cell level. Using trans-synaptic tracing from single-electroporated neurons and in vivo recordings, we show that vSUB/CA1 stimulation promotes opposite forms of in vivo plasticity at the single-cell level in the anteromedial part of the BNST (amBNST)...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28214898/early-development-of-parvalbumin-somatostatin-and-cholecystokinin-expressing-neurons-in-rat-brain-following-prenatal-immune-activation-and-maternal-iron-deficiency
#6
Patricia Boksa, Ying Zhang, Dominique Nouel, Alice Wong, Tak Pan Wong
Prenatal maternal infection and maternal iron deficiency during pregnancy are 2 early environmental insults associated with increased risk for schizophrenia in offspring. Substantial evidence suggests that abnormalities in inhibitory γ-aminobutyric acid (GABA) interneuron function, especially in the parvalbumin subtype of GABA interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28...
2016: Developmental Neuroscience
https://www.readbyqxmd.com/read/28176504/morphological-and-microstructural-changes-of-the-hippocampus-in-early-mci-a-study-utilizing-the-alzheimer-s-disease-neuroimaging-initiative-database
#7
Peter Lee, Hojin Ryoo, Jinah Park, Yong Jeong
BACKGROUND AND PURPOSE: With the aim of facilitating the early detection of Alzheimer's disease, the Alzheimer's Disease Neuroimaging Initiative proposed two stages based on the memory performance: early mild cognitive impairment (EMCI) and late mild cognitive impairment (LMCI). The current study was designed to investigate structural differences in terms of surface atrophy and microstructural changes of the hippocampus in EMCI and LMCI. METHODS: Hippocampal shape modeling based on progressive template surface deformation was performed on T1-weighted MRI images obtained from 20 cognitive normal (CN) subjects, 17 EMCI patients, and 20 LMCI patients...
January 25, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28121049/ventral-hippocampal-neurons-inhibit-postprandial-energy-intake
#8
Reilly C Hannapel, Yoko H Henderson, Rebecca Nalloor, Almira Vazdarjanova, Marise B Parent
Evidence suggests that the memory of a recently ingested meal limits subsequent intake. Given that ventral hippocampal (vHC) neurons are involved in memory and energy intake, the present experiment tested the hypothesis that vHC neurons contribute to the formation of a memory of a meal and inhibit energy intake during the postprandial period. We tested (1) whether pharmacological inactivation of vHC neurons during the period following a sucrose meal, when the memory of the meal would be undergoing consolidation, accelerates the onset of the next sucrose meal and increases intake and (2) whether sucrose intake increases vHC expression of the synaptic plasticity marker activity-regulated cytoskeletal-associated protein (Arc)...
March 2017: Hippocampus
https://www.readbyqxmd.com/read/28109982/altered-glutamate-metabolism-contributes-to-antiepileptogenic-effects-in-the-progression-from-focal-seizure-to-generalized-seizure-by-low-frequency-stimulation-in-the-ventral-hippocampus
#9
Hong-Liu Sun, Wei Zhu, Yu-Rong Zhang, Xiao-Hong Pan, Jun-Ru Zhang, Xiang-Ming Chen, Yu-Xia Liu, Shu-Cui Li, Qiao-Yun Wang, Da-Ping Deng
As a promising method for treating intractable epilepsy, the inhibitory effect of low-frequency stimulation (LFS) is well known, although its mechanisms remain unclear. Excessive levels of cerebral glutamate are considered a crucial factor for epilepsy. Therefore, we designed experiments to investigate the crucial parts of the glutamate cycle. We evaluated glutamine synthetase (GS, metabolizes glutamate), glutaminase (synthesizes glutamate), and glutamic acid decarboxylase (GAD, a γ-aminobutyric acid [GABA] synthetase) in different regions of the brain, including the dentate gyrus (DG), CA3, and CA1 subregions of the hippocampus, and the cortex, using western blots, immunohistochemistry, and enzyme activity assays...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28104542/hippocampal-morphology-and-cognitive-functions-in-community-dwelling-older-people-the-lothian-birth-cohort-1936
#10
Maria Del Carmen Valdés Hernández, Simon R Cox, Jaeil Kim, Natalie A Royle, Susana Muñoz Maniega, Alan J Gow, Devasuda Anblagan, Mark E Bastin, Jinah Park, John M Starr, Joanna M Wardlaw, Ian J Deary
Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking...
December 21, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28093473/differential-regulation-of-nmda-receptor-mediated-transmission-by-sk-channels-underlies-dorsal-ventral-differences-in-dynamics-of-schaffer-collateral-synaptic-function
#11
Walter E Babiec, Shekib A Jami, Ryan Guglietta, Patrick B Chen, Thomas J O'Dell
Behavioral, physiological, and anatomical evidence indicates that the dorsal and ventral zones of the hippocampus have distinct roles in cognition. How the unique functions of these zones might depend on differences in synaptic and neuronal function arising from the strikingly different gene expression profiles exhibited by dorsal and ventral CA1 pyramidal cells is unclear. To begin to address this question, we investigated the mechanisms underlying differences in synaptic transmission and plasticity at dorsal and ventral Schaffer collateral (SC) synapses in the mouse hippocampus...
February 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28025067/dopamine-d1-like-receptor-in-lateral-habenula-nucleus-affects-contextual-fear-memory-and-long-term-potentiation-in-hippocampal-ca1-in-rats
#12
Jiangping Chan, Xin Guan, Yiling Ni, Lilu Luo, Liqiang Yang, Pengyue Zhang, Jichuan Zhang, Yanmei Chen
The Lateral Habenula (LHb) plays an important role in emotion and cognition. Recent experiments suggest that LHb has functional interaction with the hippocampus and plays an important role in spatial learning. LHb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (VTA). However, the role of dopamine type 1 receptor (D1R) in LHb in learning and memory is not clear yet. In the present study, D1R agonist or antagonist were administered bilaterally into the LHb in rats...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27994542/the-retrograde-connections-and-anatomical-segregation-of-the-g%C3%A3-ttingen-minipig-nucleus-accumbens
#13
Anders C Meidahl, Dariusz Orlowski, Jens C H Sørensen, Carsten R Bjarkam
Nucleus accumbens (NAcc) has been implicated in several psychiatric disorders such as treatment resistant depression (TRD), and obsessive-compulsive disorder (OCD), and has been an ongoing experimental target for deep brain stimulation (DBS) in both rats and humans. In order to translate basic scientific results from rodents to the human setting a large animal model is needed to thoroughly study the effect of such therapeutic interventions. The aim of the study was, accordingly, to describe the basic anatomy of the Göttingen minipig NAcc and its retrograde connections...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27975173/acetyl-l-carnitine-via-upegulating-dopamine-d1-receptor-and-attenuating-microglial-activation-prevents-neuronal-loss-and-improves-memory-functions-in-parkinsonian-rats
#14
Sonu Singh, Akanksha Mishra, Neha Srivastava, Rakesh Shukla, Shubha Shukla
Parkinson's disease is accompanied by nonmotor symptoms including cognitive impairment, which precede the onset of motor symptoms in patients and are regulated by dopamine (DA) receptors and the mesocorticolimbic pathway. The relative contribution of DA receptors and astrocytic glutamate transporter (GLT-1) in cognitive functions is largely unexplored. Similarly, whether microglia-derived increased immune response affects cognitive functions and neuronal survival is not yet understood. We have investigated the effect of acetyl-L-carnitine (ALCAR) on cognitive functions and its possible underlying mechanism of action in 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats...
December 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27940080/sex-specific-recruitment-of-a-medial-prefrontal-cortex-hippocampal-thalamic-system-during-context-dependent-renewal-of-responding-to-food-cues-in-rats
#15
Lauren C Anderson, Gorica D Petrovich
Renewal, or reinstatement, of responding to food cues after extinction may explain the inability to resist palatable foods and change maladaptive eating habits. Previously, we found sex differences in context-dependent renewal of extinguished Pavlovian conditioned responding to food cues. Context-induced renewal involves cue-food conditioning and extinction in different contexts and the renewal of conditioned behavior is induced by return to the conditioning context (ABA renewal). Male rats showed renewal of responding while females did not...
March 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27922053/electrophysiological-properties-of-ca1-pyramidal-neurons-along-the-longitudinal-axis-of-the-mouse-hippocampus
#16
Giampaolo Milior, Maria Amalia Di Castro, Livio Pepe' Sciarria, Stefano Garofalo, Igor Branchi, Davide Ragozzino, Cristina Limatola, Laura Maggi
Evidence for different physiological properties along the hippocampal longitudinal axis is emerging. Here, we examined the electrophysiological features of neurons at different dorso-ventral sites of the mouse CA1 hippocampal region. Cell position was defined with respect to longitudinal coordinates of each slice. We measured variations in neuronal excitability, subthreshold membrane properties and neurotransmitter responses along the longitudinal axis. We found that (i) pyramidal cells of the dorsal hippocampus (DH) were less excitable than those of the ventral hippocampus (VH)...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27859884/repetition-reveals-ups-and-downs-of-hippocampal-thalamic-and-neocortical-engagement-during-mnemonic-decisions
#17
Zachariah M Reagh, Elizabeth A Murray, Michael A Yassa
The extent to which current information is consistent with past experiences and our capacity to recognize or discriminate accordingly are key factors in flexible memory-guided behavior. Despite a wealth of evidence linking hippocampal and neocortical computations to these phenomena, many important factors remain poorly understood. One such factor is repeated encoding of learned information. In this experiment, participants completed a task in which study stimuli were incidentally encoded either once or three separate times during high-resolution fMRI scanning...
November 16, 2016: Hippocampus
https://www.readbyqxmd.com/read/27857753/serotonin-regulates-brain-derived-neurotrophic-factor-expression-in-select-brain-regions-during-acute-psychological-stress
#18
De-Guo Jiang, Shi-Li Jin, Gong-Ying Li, Qing-Qing Li, Zhi-Ruo Li, Hong-Xia Ma, Chuan-Jun Zhuo, Rong-Huan Jiang, Min-Jie Ye
Previous studies suggest that serotonin (5-HT) might interact with brain-derived neurotrophic factor (BDNF) during the stress response. However, the relationship between 5-HT and BDNF expression under purely psychological stress is unclear. In this study, one hour before psychological stress exposure, the 5-HT1A receptor agonist 8-OH-DPAT or antagonist MDL73005, or the 5-HT2A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress. Immunohistochemistry and in situ hybridization revealed that after psychological stress, with the exception of the ventral tegmental area, BDNF protein and mRNA expression levels were higher in the 5-HT1A and the 5-HT2A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and the midbrain periaqueductal gray...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27764670/in-situ-transcription-profiling-of-single-cells-reveals-spatial-organization-of-cells-in-the-mouse-hippocampus
#19
Sheel Shah, Eric Lubeck, Wen Zhou, Long Cai
Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 cells to examine whether the hippocampus is organized into transcriptionally distinct subregions. We identified distinct layers in the dentate gyrus corresponding to the granule cell layer and the subgranular zone and, contrary to previous reports, discovered that distinct subregions within the CA1 and CA3 are composed of unique combinations of cells in different transcriptional states...
October 19, 2016: Neuron
https://www.readbyqxmd.com/read/27733611/reward-expectancy-strengthens-ca1-theta-and-beta-band-synchronization-and-hippocampal-ventral-striatal-coupling
#20
Carien S Lansink, Guido T Meijer, Jan V Lankelma, Martin A Vinck, Jadin C Jackson, Cyriel M A Pennartz
The use of information from the hippocampal memory system in motivated behavior depends on its communication with the ventral striatum. When an animal encounters cues that signal subsequent reward, its reward expectancy is raised. It is unknown, however, how this process affects hippocampal dynamics and their influence on target structures, such as ventral striatum. We show that, in rats, reward-predictive cues result in enhanced hippocampal theta and beta band rhythmic activity during subsequent action, compared with uncued goal-directed navigation...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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