keyword
MENU ▼
Read by QxMD icon Read
search

ventral CA1

keyword
https://www.readbyqxmd.com/read/29913405/carbamazepine-induced-suppression-of-repetitive-firing-in-ca1-pyramidal-neurons-is-greater-in-the-dorsal-hippocampus-than-the-ventral-hippocampus
#1
Madeline Collette Evans, Kelly Ann Dougherty
Medial temporal lobe epilepsy (mTLE)-the most common form of focal epilepsy-is defined by recurrent partial seizures originating within the medial temporal lobe. Such seizures are commonly associated with the anterior hippocampus (as opposed to the posterior hippocampus), and refractory to the currently available anti-epileptic drugs (AED) for about one third of patients. Unfortunately, the mechanisms driving seizure generation and AED efficacy along the longitudinal hippocampal axis remain poorly understood...
June 9, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29909994/the-bdnf-val66met-prodomain-disassembles-dendritic-spines-altering-fear-extinction-circuitry-and-behavior
#2
Joanna I Giza, Jihye Kim, Heidi C Meyer, Agustin Anastasia, Iva Dincheva, Crystal I Zheng, Katherine Lopez, Henrietta Bains, Jianmin Yang, Clay Bracken, Conor Liston, Deqiang Jing, Barbara L Hempstead, Francis S Lee
A human variant in the BDNF gene (Val66Met; rs6265) is associated with impaired fear extinction. Using super-resolution imaging, we demonstrate that the BDNF Met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. In vivo, ventral CA1 (vCA1) hippocampal neurons undergo similar morphological changes dependent on their transient co-expression of a SorCS2/p75NTR receptor complex during peri-adolescence. BDNF Met prodomain infusion into the vCA1 during this developmental time frame reduces dendritic spine density and prelimbic (PL) projections, impairing cued fear extinction...
June 2, 2018: Neuron
https://www.readbyqxmd.com/read/29807127/contextual-fear-retrieval-induced-fos-expression-across-early-development-in-the-rat-an-analysis-using-established-nervous-system-nomenclature-ontology
#3
Anthony J Santarelli, Arshad M Khan, Andrew M Poulos
The neural circuits underlying the acquisition, retention and retrieval of contextual fear conditioning have been well characterized in the adult animal. A growing body of work in younger rodents indicates that context-mediated fear expression may vary across development. However, it remains unclear how this expression may be defined across the full range of key developmental ages. Nor is it fully clear whether the structure of the adult context fear network generalizes to earlier ages. In this study, we compared context fear retrieval-induced behavior and neuroanatomically constrained immediate early-gene expression across infant (P19), early and late juvenile (P24 and P35), and adult (P90) male Long-Evans rats...
May 25, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29747244/nucleus-reuniens-of-the-thalamus-controls-fear-memory-intensity-specificity-and-long-term-maintenance-during-consolidation
#4
Fernanda Troyner, Maira A Bicca, Leandro J Bertoglio
The thalamic nucleus reuniens (NR) has been shown to support bidirectional medial prefrontal cortex-hippocampus communication and synchronization relevant for cognitive processing. Using non-selective or prolonged inactivation of the NR, previous studies reported its activity positively modulates aversive memory consolidation. Here we examined the NR's role in consolidating contextual fear memories with varied strength, at both recent and more remote time points, using muscimol-induced temporary inactivation in rats...
May 10, 2018: Hippocampus
https://www.readbyqxmd.com/read/29731678/expression-of-%C3%A2%C2%B5-opioid-receptor-in-ca1-hippocampal-astrocytes
#5
Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Jin Young Bae, Heeyoung An, Seahyung Park, Soo-Jin Oh, Eunju Kim, Eunmi Hwang, Yong Chul Bae, C Justin Lee
µ-opioid receptor (MOR) is a class of opioid receptors with a high affinity for enkephalins and beta-endorphin. In hippocampus, activation of MOR is known to enhance the neuronal excitability of pyramidal neurons, which has been mainly attributed to a disinhibition of pyramidal neurons via activating Gαi subunit to suppress the presynaptic release of GABA in hippocampal interneurons. In contrast, the potential role of MOR in hippocampal astrocytes, the most abundant cell type in the brain, has remained unexplored...
April 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/29691979/the-brain-derived-neurotrophic-factor-val68met-polymorphism-modulates-how-developmental-ethanol-exposure-impacts-the-hippocampus
#6
C W Bird, B C Baculis, J J Mayfield, G J Chavez, T Ontiveros, D J Paine, A J Marks, A L Gonzales, D Ron, C F Valenzuela
Prenatal exposure to alcohol causes a wide range of deficits known as fetal alcohol spectrum disorders (FASDs). Many factors determine vulnerability to developmental alcohol exposure including timing and pattern of exposure, nutrition and genetics. Here, we characterized how a prevalent single nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (val66met) modulates FASDs severity. This polymorphism disrupts BDNF's intracellular trafficking and activity-dependent secretion, and has been linked to increased incidence of neuropsychiatric disorders such as depression and anxiety...
April 24, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29681795/delta-opioid-receptor-signaling-promotes-resilience-to-stress-under-the-repeated-social-defeat-paradigm-in-mice
#7
Mathilde S Henry, Kanchan Bisht, Nathalie Vernoux, Louis Gendron, Angélica Torres-Berrio, Guy Drolet, Marie-Ève Tremblay
The adaptation to chronic stress is highly variable across individuals. Resilience to stress is a complex process recruiting various brain regions and neurotransmitter systems. The aim of this study was to investigate the involvement of endogenous opioid enkephalin (ENK) signaling in the development of stress resilience in mice. The translational model of repeated social defeat (RSD) stress was selected to mimic the unpredictable disruptions of daily life and induce resilience or vulnerability to stress. As in humans, adult C57BL/6J mice demonstrated a great variability in their response to stress under this paradigm...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29653257/%C3%AE-adrenergic-receptors-reduce-the-threshold-for-induction-and-stabilization-of-ltp-and-enhance-its-magnitude-via-multiple-mechanisms-in-the-ventral-but-not-the-dorsal-hippocampus
#8
Vassilios Papaleonidopoulos, Costas Papatheodoropoulos
The hippocampus is a functionally heterogeneous structure with the cognitive and emotional signal processing ascribed to the dorsal (DH) and the ventral hippocampus (VH) respectively. However, the underlying mechanisms are poorly understood. Noradrenaline is released in hippocampus during emotional arousal modulating synaptic plasticity and memory consolidation through activation of β adrenergic receptors (β-ARs). Using recordings of field excitatory postsynaptic potentials from the CA1 field of adult rat hippocampal slices we demonstrate that long-term potentiation (LTP) induced either by theta-burst stimulation (TBS) that mimics a physiological firing pattern of hippocampal neurons or by high-frequency stimulation is remarkably more sensitive to β-AR activation in VH than in DH...
May 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29624516/neural-pathways-in-medial-septal-cholinergic-modulation-of-chronic-pain-distinct-contribution-of-the-anterior-cingulate-cortex-and-ventral-hippocampus
#9
Ying-Ying Jiang, Shan Shao, Yu Zhang, Jie Zheng, Xi Chen, Shuang Cui, Feng-Yu Liu, You Wan, Ming Yi
One specific behavior can be synergistically modulated by different neural pathways. Medial septal (MS) cholinergic system innervates widespread cortical and subcortical regions and participates in pain modulation, but the underlying neural pathways are not fully understood. This study examined the contribution of MS cholinergic neurons and 2 neural pathways: MS-rostral anterior cingulate cortex (rACC) and MS-ventral hippocampal CA1 (vCA1), in modulating perceptual and affective pain behaviors in a mouse model of chronic inflammatory pain...
April 5, 2018: Pain
https://www.readbyqxmd.com/read/29606418/ventral-hippocampal-ca1-and-ca3-differentially-mediate-learned-approach-avoidance-conflict-processing
#10
Anett Schumacher, Franz R Villaruel, Alicia Ussling, Sadia Riaz, Andy C H Lee, Rutsuko Ito
Approach-avoidance conflict arises when an animal encounters a stimulus that is associated simultaneously with positive and negative valences [1]. The effective resolution of approach-avoidance conflict is critical for survival and is believed to go awry in a number of mental disorders, such as anxiety and addiction. An accumulation of evidence from both rodents and humans suggests that the ventral hippocampus (anterior in humans) plays a key role in approach-avoidance conflict processing [2-8], with one influential model proposing that this structure modulates behavioral inhibition in the face of conflicting goals by increasing the influence of negative valences [9]...
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29570499/ketamine-effects-on-mammalian-target-of-rapamycin-signaling-in-the-mouse-limbic-system-depend-on-functional-dopamine-d3-receptors
#11
Cristiano Chiamulera, Marzia di Chio, Laura Cavalleri, Marco Venniro, Laura Padovani, Ginetta Collo
Ketamine is a noncompetitive glutamate N-methyl-D-aspartic acid receptor antagonist. When acutely administered to rodents, it produces a rapid antidepressant effect. There is evidence that N-methyl-D-aspartic acid receptor blockade enhances glutamatergic transmission preferentially engaging α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leading to mTOR (mammalian target of rapamycin) pathways activation, thus resulting into downstream neuroadaptive changes in limbic structures. Recent in-vitro data on primary neuronal cultures showed that ketamine activates mTOR also in dopaminergic neurons, and this activation depends on the presence of functional dopamine D3 receptors...
May 23, 2018: Neuroreport
https://www.readbyqxmd.com/read/29550518/hippocampal-modulation-of-cardiorespiratory-function
#12
Itopa E Ajayi, Alice E McGovern, Alexandria K Driessen, Nicole F Kerr, Paul C Mills, Stuart B Mazzone
Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have focussed on the role of the prefrontal cortex in autonomic regulation. However, the role of the hippocampus, also important in limbic processing, has not been addressed in detail. Anaesthetised, instrumented rats were used to map the location of hippocampal sites capable of evoking changes in cardiorespiratory control showing that stimulation of discrete regions within the CA1 fields of both the dorsal and ventral hippocampus potently alter breathing and cardiovascular activity...
June 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29537707/effects-of-endogenous-and-exogenous-d1-d5-dopamine-receptor-activation-on-ltp-in-ventral-and-dorsal-ca1-hippocampal-synapses
#13
Vassilios Papaleonidopoulos, Stylianos Kouvaros, Costas Papatheodoropoulos
Hippocampus is importantly involved in dopamine-dependent behaviors and dopamine is a significant modulator of synaptic plasticity in the hippocampus. Moreover, the dopaminergic innervation appears to be disproportionally segregated along the hippocampal longitudinal (dorsoventral) axis with unknown consequences for synaptic plasticity. In this study we examined the actions of endogenously released dopamine and the effects of exogenous D1/D5 dopamine receptor agonists on theta-burst stimulation-induced long-term potentiation (LTP) of field excitatory synaptic potential (fEPSP) at Schaffer collateral-CA1 synapses in slices from dorsal (DH) and ventral hippocampus (VH)...
March 14, 2018: Synapse
https://www.readbyqxmd.com/read/29518566/abstinence-to-chronic-methamphetamine-switches-connectivity-between-striatal-hippocampal-and-sensorimotor-regions-and-increases-cerebral-blood-volume-response
#14
Ji-Kyung Choi, Grewo Lim, Yin-Ching Iris Chen, Bruce G Jenkins
Methamphetamine (meth), and other psychostimulants such as cocaine, present a persistent problem for society with chronic users being highly prone to relapse. We show, in a chronic methamphetamine administration model, that discontinuation of drug for more than a week produces much larger changes in overall meth-induced brain connectivity and cerebral blood volume (CBV) response than changes that occur immediately following meth administration. Areas showing the largest changes were hippocampal, limbic striatum and sensorimotor cortical regions as well as brain stem areas including the pedunculopontine tegmentum (PPTg) and pontine nuclei - regions known to be important in mediating reinstatement of drug-taking after abstinence...
July 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29432803/learning-and-memory-is-modulated-by-cannabidiol-when-administered-during-trace-fear-conditioning
#15
A L Uhernik, Z T Montoya, C D Balkissoon, J P Smith
Cannabidiol (CBD) is thought to have therapeutic potential for treating psychiatric conditions that affect cognitive aspects of learning and memory, including anxiety and post-traumatic stress disorder (PTSD). Studies have shown that CBD enhances extinction of fear memory when given after conditioning. This led us to hypothesize that CBD, if administered prior to fear conditioning, might modulate cognitive learning and memory processes in additional ways that would further guide its potential use for treating PTSD...
March 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29410218/cholinergic-neurons-in-medial-septum-maintain-anxiety-like-behaviors-induced-by-chronic-inflammatory-pain
#16
Ying-Ying Jiang, Yu Zhang, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
Cholinergic neurons in the medial septum (MS) participate in various cognitive and emotional behaviors, including innate anxiety. Chronic pain involves perceptual, cognitive and emotional components. Whether MS cholinergic system modulates pain-induced anxiety and the underlying neural circuits are involved remain unclear. In the present study, we showed that chemogenetic (DREADD) inhibition of MS cholinergic neurons relieved pain-induced anxiety-like behaviors in open field and elevated plus maze tests. Inhibiting the MS-rostral anterior cingulate cortex (rACC), but not the MS-ventral hippocampal CA1 pathway, achieved anxiolysis...
April 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29397273/anxiety-cells-in-a-hippocampal-hypothalamic-circuit
#17
Jessica C Jimenez, Katy Su, Alexander R Goldberg, Victor M Luna, Jeremy S Biane, Gokhan Ordek, Pengcheng Zhou, Samantha K Ong, Matthew A Wright, Larry Zweifel, Liam Paninski, René Hen, Mazen A Kheirbek
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vCA1 population projecting to the lateral hypothalamic area (LHA) but not to the basal amygdala (BA)...
February 7, 2018: Neuron
https://www.readbyqxmd.com/read/29377353/blockade-of-dopamine-d2-receptors-disrupts-intrahippocampal-connectivity-and-enhances-pain-related-working-memory-deficits-in-neuropathic-pain-rats
#18
H Cardoso-Cruz, M Dourado, C Monteiro, V Galhardo
BACKGROUND: Dopamine (DA) is thought to be important to local hippocampal networks integrity during spatial working memory (sWM) processing. Chronic pain may contribute to deficient dopaminergic signalling, which may in turn affect cognition. However, the neural mechanisms that determine this impairment are poorly understood. Here, we evaluated whether the sWM impairment characteristic of animal models of chronic pain is dependent on DA D2 receptor (D2r) activity. METHODS: To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 field (dvCA1) of rats and recorded the neuronal activity during a classical delayed food-reinforced T-maze sWM task...
May 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29355673/a-role-for-ca3-in-social-recognition-memory
#19
Ming-Ching Chiang, Arthur J Y Huang, Marie E Wintzer, Toshio Ohshima, Thomas J McHugh
Social recognition memory is crucial for survival across species, underlying the need to correctly identify conspecifics, mates and potential enemies. In humans the hippocampus is engaged in social and episodic memory, however the circuit mechanisms of social memory in rodent models has only recently come under scrutiny. Work in mice has established that the dorsal CA2 and ventral CA1 regions play critical roles, however a more comprehensive comparative analyses of the circuits and mechanisms required has not been reported...
February 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29233091/a-gradient-of-frequency-dependent-synaptic-properties-along-the-longitudinal-hippocampal-axis
#20
Vassilios Papaleonidopoulos, George Trompoukis, Andriana Koutsoumpa, Costas Papatheodoropoulos
BACKGROUND: The hippocampus is a functionally heterogeneous brain structure and specializations of the intrinsic neuronal network may crucially support the functional segregation along the longitudinal axis of the hippocampus. Short-term synaptic plasticity plays fundamental roles in information processing and may be importantly involved in diversifying the properties of local neuronal network along the hippocampus long axis. Therefore, we aimed to examine the properties of the cornu ammonis 1 (CA1) synapses along the entire dorsoventral axis of the rat hippocampus using field excitatory postsynaptic potentials from transverse rat hippocampal slices and a frequency stimulation paradigm...
December 12, 2017: BMC Neuroscience
keyword
keyword
100284
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"