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https://www.readbyqxmd.com/read/28927088/pcdh8-inhibits-glioma-cell-proliferation-by-negatively-regulating-the-akt-gsk3%C3%AE-%C3%AE-catenin-signaling-pathway
#1
Zhenkun Zong, Hui Pang, Rutong Yu, Yunqi Jiao
Protocadherin-8 (PCDH8), a member of the protocadherin superfamily of proteins, is frequently lost in numerous types of cancer. However, the role that PCDH8 serves in human glioma, and the molecular mechanisms underlying this, remain unclear. Data from the present study demonstrated that the expression levels of PCDH8 mRNA and protein were significantly decreased in human glioma tissue compared with normal brain tissue. This suggested that PCDH8 is associated with the development of glioma. Thus, the role of PCDH8 in glioma cell proliferation was investigated by silencing and overexpressing PCDH8 in U251 glioma cells...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927024/in-vitro-activities-of-enantiopure-and-racemic-1-acetoxychavicol-acetate-against-clinical-isolates-of-mycobacterium-tuberculosis
#2
Saradee Warit, Kamolchanok Rukseree, Therdsak Prammananan, Poonpilas Hongmanee, Pamaree Billamas, Sarinya Jaitrong, Angkana Chaiprasert, Birgit U Jaki, Guido F Pauli, Scott G Franzblau, Prasit Palittapongarnpim
In the process of evaluating the effect of several plant extracts against Mycobacterium tuberculosis using the Microplate Alamar Blue Assay (MABA), an extract of Thai herb Alpinia galanga rhizome and its major component, 1'-acetoxychavicol acetate (ACA), exhibited marked anti-tuberculosis activity. The minimal inhibition concentrations (MICs) of the S-enantiomer of ACA (S-ACA) against M. tuberculosis H37Ra ATCC 25177 and H37Rv ATCC 27294 strains were 0.2 µg/mL and 0.7 µg/mL, respectively. More than 95% of 100 drug-sensitive and 50 drug-resistant mycobacterial clinical isolates were inhibited by extracted S-ACA at 1...
September 18, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28923883/microtubules-associated-rac-regulation-of-endothelial-barrier-a-role-of-asef-in-acute-lung-injury
#3
Pratap Karki, Anna A Birukova
The endothelial barrier function regulated by the cytoskeletal reorganizations has been implicated in the pathogenesis of multiple lung diseases including asthma, sepsis, edema, and acute respiratory distress syndrome. The extensive studies have established that activation of small GTPase Rac is a key mechanism in endothelial barrier protection but the role of microtubules-associated Rac in the endothelial functions remains poorly understood. With the emerging evidences that microtubules disassembly also plays a critical role in actin cytoskeleton remodeling leading to endothelial permeability, the knowledge on microtubules-mediated regulation of endothelial barrier is imperative to better understand the etiology of lung injuries as well as to develop novel therapeutics against these disorders...
September 18, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28920944/the-dosage-dependent-effect-exerted-by-the-nm23-h1-h2-homolog-ndk-1-on-distal-tip-cell-migration-in-c-elegans
#4
Zsolt Farkas, Luca Fancsalszky, Éva Saskői, Alexandra Gráf, Krisztián Tárnok, Anil Mehta, Krisztina Takács-Vellai
Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are fundamental properties of metastatic cells. The first identified metastasis suppressor NM23-H1, which displays nucleoside-diphosphate kinase (NDPK) activity is involved in these processes. NM23-H1 inhibits the migratory and invasive potential of some cancer cells. Correspondingly, numerous invasive cancer cell lines (eg, breast, colon, oral, hepatocellular carcinoma, and melanoma) display low endogenous NM23 levels. In this review, we summarize mechanisms, which are linked to the anti-metastatic activity of NM23...
September 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28920626/mononuclear-salen-gallium-complexes-for-iso-selective-ring-opening-polymerization-rop-of-rac-lactide
#5
David Specklin, Christophe Fliedel, Frédéric Hild, Samir Mameri, Lydia Karmazin, Corinne Bailly, Samuel Dagorne
A series of mononuclear salen-supported gallium amido/alkoxide derivatives were prepared and structurally characterized and subsequently used as initiators in rac-lactide ring-opening polymerisation (ROP). The reaction of variously substituted salen ligands (1a-1f) with 0.5 equiv. of Ga2(NMe2)6 allowed the isolation of the corresponding (salen)Ga-NMe2 chelates (2b-2d, 2f) via an amine elimination route, as poorly soluble compounds in common solvents. The (salen)Ga-OBn derivatives (3a-3e) may be readily accessed by an amine-elimination/alcoholysis sequence and the molecular structures of 3a, 3d and 3e were confirmed through X-ray crystallography diffraction analysis...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28919642/membrane-binding-of-parkinson-s-protein-%C3%AE-synuclein-effect-of-phosphorylation-at-positions-87-and-129-by-the-s-to-d-mutation-approach
#6
Pravin Kumar, Nathalie Schilderink, Vinod Subramaniam, Martina Huber
Human α-synuclein, a protein relevant in the brain with so-far unknown function, plays an important role in Parkinson's disease. The phosphorylation state of αS was related to the disease, prompting interest in this process. The presumed physiological function and the disease action of αS involves membrane interaction. Here, we study the effect of phosphorylation at positions 87 and 129, mimicked by the mutations S87A, S129A (nonphosphorylated) and S87D, S129D (phosphorylated) on membrane binding. Local binding is detected by spin-label continuous-wave electron paramagnetic resonance...
July 2017: Israel Journal of Chemistry
https://www.readbyqxmd.com/read/28906441/bonding-behavior-of-deformed-steel-rebars-in-sustainable-concrete-containing-both-fine-and-coarse-recycled-aggregates
#7
Sun-Woo Kim, Wan-Shin Park, Young-Il Jang, Seok-Joon Jang, Hyun-Do Yun
In order to assess the bond behavior of deformed steel rebars in recycled-aggregate concrete (RAC) incorporating both fine and coarse recycled aggregate, pull-out tests were carried out in this study on 16-mm diameter deformed steel rebars embedded concentrically in RAC. The concrete was designed using equivalently mixed proportions of both recycled coarse aggregate and recycled fine aggregate. The tests employed five types of recycled aggregate replacement combinations and three types of rebar placement orientation (i...
September 14, 2017: Materials
https://www.readbyqxmd.com/read/28903685/evaluating-the-dimensionality-of-self-determination-theory-s-relative-autonomy-continuum
#8
Kennon M Sheldon, Evgeny N Osin, Tamara O Gordeeva, Dmitry D Suchkov, Oleg A Sychev
We conducted a theoretical and psychometric evaluation of self-determination theory's "relative autonomy continuum" (RAC), an important aspect of the theory whose validity has recently been questioned. We first derived a Comprehensive Relative Autonomy Index (C-RAI) containing six subscales and 24 items, by conducting a paired paraphrase content analysis of existing RAI measures. We administered the C-RAI to multiple U.S. and Russian samples, assessing motivation to attend class, study a major, and take responsibility...
September 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28901419/microrna%C3%A2-21-increases-cell-viability-and-suppresses-cellular-apoptosis-in-non%C3%A2-small-cell-lung-cancer-by-regulating-the-pi3k-akt-signaling-pathway
#9
Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Dai
MicroRNA (miRNA/miR), a type of non‑coding RNA molecule, is able to inhibit the expression of target genes at multiple stagess. There are 800‑1,000 known miRNAs in the human genome, which serve important roles in cell proliferation, differentiation, apoptosis and migration. Previous studies have demonstrated that the expression of miR‑21 is upregulated in numerous types of malignant tumor, and that miR‑21 participates in the occurrence and development of tumors via complex regulatory mechanisms. The present study aimed to investigate the association between miR‑21 expression, cell viability and apoptosis in a lung cancer cell line, and to elucidate the potential mechanisms...
September 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898496/cumulative-incidence-of-admission-to-permanent-residential-aged-care-for-australian-women-a-competing-risk-analysis
#10
Peta Forder, Julie Byles, Kha Vo, Cassie Curryer, Deborah Loxton
OBJECTIVE: To provide a direct estimate of the risk of admission to permanent residential aged care among older women while accounting for death, according to housing type and other variables. METHODS: A competing risk analysis from 8,867 Australian women born 1921-26, using linked data from the Australian Longitudinal Study on Women's Health (ALSWH), Residential Aged Care (RAC), and the Australian National Death Index. RESULTS: After accounting for deaths, around 35% of women will be admitted to RAC between ages 73 and 90...
September 12, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28894027/activation-status-coupled-transient-s-acylation-determines-membrane-partitioning-of-a-plant-rho-related-gtpase
#11
Nadav Sorek, Limor Poraty, Hasana Sternberg, Ella Buriakovsky, Einat Bar, Efraim Lewinsohn, Shaul Yalovsky
ROPs or RACs are plant Rho-related GTPases implicated in regulation of multitude of signaling pathways that function at the plasma membrane via posttranslational lipid modifications. The relations between ROP activation status and their membrane localization has not been established. Here, we show that endogenous ROPs, as well as a transgenic His6:GFP:AtROP6 fusion protein, were partitioned between Triton X-100 soluble and insoluble membranes. In contrast, the His6:GFP:Atrop6(CA) activated mutant accumulated exclusively in detergent resistant membranes...
September 11, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28893556/the-ilk-mmp9-mrtf-axis-is-crucial-for-endmt-differentiation-of-endothelial-cells-in-a-tumor-microenvironment
#12
Wojciech M Ciszewski, Katarzyna Sobierajska, Marta E Wawro, Wanda Klopocka, Natasza Chefczyńska, Angelika Muzyczuk, Kamil Siekacz, Agata Wujkowska, Jolanta Niewiarowska
Increasing evidence indicates that the tumor microenvironment is a critical factor supporting cancer progression, chemoresistance and metastasis. Recently, cancer-associated fibroblasts (CAFs) have been recognized as a crucial tumor stromal component promoting cancer growth and invasiveness via modulation of the extracellular matrix (ECM) structure, tumor metabolism and immune reprogramming. One of the main sources of CAFs are endothelial cells undergoing the endothelial-mesenchymal transition (EndMT). EndMT is mainly promoted by the Transforming Growth Factor-β (TGF-β) family secreted by tumor cells, though the role of particular members in EndMT regulation remains poorly understood...
September 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28888781/siglec-8-is-an-activating-receptor-mediating-%C3%AE-2-integrin-dependent-function-in-human-eosinophils
#13
Daniela J Carroll, Jeremy A O'Sullivan, David B Nix, Yun Cao, Michael Tiemeyer, Bruce S Bochner
BACKGROUND: Siglec-8 is a CD33 subfamily cell surface receptor that is selectively expressed on human eosinophils. Following cytokine-priming, Siglec-8 mAb or glycan ligand binding causes eosinophil apoptosis associated with reactive oxygen species (ROS) production. Most CD33-related Siglecs function as inhibitory receptors, but the ability of Siglec-8 to stimulate eosinophil ROS production and apoptosis suggests that Siglec-8 may instead function as an activating receptor. OBJECTIVE: To determine the role of IL-5 priming and to identify the signaling molecules involved in Siglec-8 function for human eosinophils...
September 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28886159/directional-migration-of-mesenchymal-stem-cells-under-an-sdf-1%C3%AE-gradient-on-a-microfluidic-device
#14
Siwan Park, Hwanseok Jang, Byung Soo Kim, Changmo Hwang, Gi Seok Jeong, Yongdoo Park
Homing of peripheral stem cells is regulated by one of the most representative homing factors, stromal cell-derived factor 1 alpha (SDF-1α), which specifically binds to the plasma membrane receptor CXCR4 of mesenchymal stem cells (MSCs) in order to initiate the signaling pathways that lead to directional migration and homing of stem cells. This complex homing process and directional migration of stem cells have been mimicked on a microfluidic device that is capable of generating a chemokine gradient within the collagen matrix and embedding endothelial cell (EC) monolayers to mimic blood vessels...
2017: PloS One
https://www.readbyqxmd.com/read/28884730/-pharmacological-effects-and-clinical-application-of-pantogam-and-pantogam-active
#15
T A Voronina, S A Litvinova
Clinical studies and experience in the use of pantogam (hopanthenic acid) and pantogam active (rac-gopantenic/D-, L-gopantenic acid) showed their efficacy and safety in patients with various pathologies. Pantogam has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal syndrome. Pantogam active, having also an additional anxiolytic effect, is characterized by bimodal activity, improves not only cognitive functions, but also emotional state in patients in psychiatric, neurological and cardiological practice with such diseases and conditions as anxiety/anxiety-depressive disorders, chronic brain ischemia, ischemic heart disease, chronic heart failure, arterial hypertension, epilepsy, craniocerebral trauma, schizophrenia as well as cognitive impairment in the structure of neurological and psychogenic deficiencies...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28878295/garcinone-e-induces-apoptosis-and-inhibits-migration-and-invasion-in-ovarian-cancer-cells
#16
Xiao-Huang Xu, Qian-Yu Liu, Ting Li, Jian-Lin Liu, Xin Chen, Li Huang, Wen-An Qiang, Xiuping Chen, Yitao Wang, Li-Gen Lin, Jin-Jian Lu
Ovarian cancer remains the most lethal gynecological malignant tumor. In this study, 24 xanthones were isolated and identified from the pericarps of mangosteen (Garcinia mangostana), and their anti-proliferative activities were tested in ovarian cancer cells. Garcinone E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones. It significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells as evidenced by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876913/stereoselective-bioaccumulation-of-water-and-soil-associated-dufulin-enantiomers-in-tubifex
#17
Jing Li, Ping Lu, Deyu Hu, Shouyi Wang, Qingtao Zhang, Yurong Yu, Song Zeng
In this study, the stereoselective bioaccumulation of rac-dufulin, pure S-(+)-dufulin, and pure R-(-)-dufulin in Tubifex (Oligochaeta, Tubificida) were analyzed in spiked-water and spiked-soil systems at low and high dose levels. In the bioaccumulation experiments treated with rac-dufulin, the enantioselective behaviors of the enantiomers show that the concentrations of R-(-)-dufulin are higher than those of S-(+)-dufulin at two dose levels. However, when treated with solely pure S-(+)-dufulin and R-(-)-dufulin, no significant difference of concentrations was detected in Tubifex...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28875350/enantioconvergent-hydrolysis-of-racemic-styrene-oxide-at-high-concentration-by-a-pair-of-novel-epoxide-hydrolases-into-r-phenyl-1-2-ethanediol
#18
Rui Wang, Die Hu, Xuncheng Zong, Jinping Li, Lei Ding, Minchen Wu, Jianfang Li
OBJECTIVES: To prepare (R)-phenyl-1,2-ethanediol ((R)-PED) with high enantiomeric excess (ee p) and yield from racemic styrene oxide (rac-SO) at high concentration by bi-enzymatic catalysis. RESULTS: The bi-enzymatic catalysis was designed for enantioconvergent hydrolysis of rac-SO by a pair of novel epoxide hydrolases (EHs), a Vigna radiata EH3 (VrEH3) and a variant (AuEH2(A250I)) of Aspergillus usamii EH2. The simultaneous addition mode of VrEH3 and AuEH2(A250I), exhibiting the highest average turnover frequency (aTOF) of 0...
September 5, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28873647/influence-of-biopolymers-on-the-solubility-of-branched-chain-amino-acids-and-stability-of-their-solutions
#19
Chi Rac Hong, Gyu Whan Lee, Hyun-Dong Paik, Pahn-Shick Chang, Seung Jun Choi
This study confirmed the possibility of biopolymer-type stabilizers to increase the saturation concentration of branched-chain amino acids by preventing their crystallization/precipitation. Although microfluidization increased the initial solubility, it failed to increase the saturation concentration of the branched-chain amino acids. The saturation concentration of the branched-chain amino acids increased from 3.81% to 4.42% and 4.85% after the incorporation of food hydrocolloids and proteins, respectively...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28870903/role-of-arhgap24-in-adp-ribosylation-factor-6-arf6-dependent-pseudopod-formation-in-human-breast-carcinoma-cells
#20
Shota Uehara, Koji Saito, Hisayo Asami, Yasutaka Ohta
BACKGROUND/AIM: The small GTPase ADP ribosylation factor 6 (ARF6) promotes carcinoma cell invasion and metastasis through remodeling of actin cytoskeleton and formation of pseudopod that is regulated by RAC. RHO GTPase activating protein 24 (ARHGAP24), a RAC-specific GTPase activating protein, binds to activated ARF6 and is recruited to the plasma membrane. The aim of the present study was to demonstrate if ARHGAP24 is involved in the ARF6-mediated formation of pseudopods in breast carcinoma cells...
September 2017: Anticancer Research
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