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https://www.readbyqxmd.com/read/29661929/arginase-1-expression-in-myeloid-cells-regulates-s-aureus-planktonic-but-not-biofilm-infection
#1
Kelsey J Yamada, Cortney E Heim, Amy L Aldrich, Casey M Gries, Anna G Staudacher, Tammy Kielian
S. aureus is a leading cause of device-associated biofilm infections, which represent a serious health care concern based on their chronicity and antibiotic resistance. We previously reported that S. aureus biofilms preferentially recruit myeloid-derived suppressor cells (MDSCs), which promote monocyte and macrophage anti-inflammatory properties. This is associated with increased myeloid arginase-1 (Arg-1) expression, which has been linked to anti-inflammatory and pro-fibrotic activity that are observed during S...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29652869/effect-of-sustained-hypoxia-on-autophagy-of-genioglossus-muscle-derived-stem-cells
#2
Dongsheng Zhang, Shanshan Jia, Hengkun Wang, Shengyun Huang, Lili Xiao, Li Ma, Guangping Liu, Kun Gong, Le Xu
BACKGROUND Previous studies have demonstrated that sustained hypoxia in people with obstructive sleep apnea (OSA) impairs upper airway muscle activity, but the underlying mechanism remains poorly understood. As autophagy acts as an important regulator under hypoxia stress, we performed an in vitro investigation of the effects of sustained hypoxia on autophagy of genioglossus muscle-derived stem cells (GG MDSC), an important component of the upper airway muscle. MATERIAL AND METHODS Genioglossus MDSCs were obtained from Sprague-Dawley (SD) rats and identified by using immunofluorescence staining for CD34, Sca-1, and desmin...
April 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29628788/the-role-of-hypoxia-in-shaping-the-recruitment-of-proangiogenic-and-immunosuppressive-cells-in-the-tumor-microenvironment
#3
REVIEW
Salem Chouaib, Viktor Umansky, Claudine Kieda
Hypoxia characterizes growing tumors and contributes significantly to their aggressiveness. Hypoxia-inducible factors (HIFs 1 and 2) are stabilized and act differentially as transcription factors on tumor growth and are responsible for important cancer hallmarks such as pathologic angiogenesis, cellular proliferation, apoptosis, differentiation and genetic instability as well as affecting tumor metabolism, tumor immune responses, invasion and metastasis. Taking into account the tumor tissue as a whole and considering the interplay of the various partners which react with hypoxia in the tumor site lead to reconsideration of the treatment strategies...
March 2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29621426/tumor-infiltrating-treg-mdsc-and-ido-expression-associated-with-outcomes-of-neoadjuvant-chemotherapy-of-breast-cancer
#4
Fangxuan Li, Yang Zhao, Lijuan Wei, Shixia Li, Juntian Liu
BACKGROUND: Regulatory T cells(Tregs) and myeloid-derived suppressor cells(MDSCs) represent two immunosuppressive cell populations that are important in the establishment and maintenance of cancer immune tolerance. MDSCs can express IDO and promote immune tolerance via expansion of Treg cell. METHOD: We use needle biopsy breast cancer tissues prior to neoadjuvant chemotherapy(NCT) staining for CD33, Foxp3 and IDO by immunohistochemistry to evaluate whether they were correlated with subsequent treatment responses in breast cancer...
April 5, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29621339/clarithromycin-expands-cd11b-gr-1-cells-via-the-stat3-bv8-axis-to-ameliorate-lethal-endotoxic-shock-and-post-influenza-bacterial-pneumonia
#5
Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu, Tomoko Betsuyaku
Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29619980/targeting-myeloid-derived-suppressor-cells-and-programmed-death-ligand-1-confers-therapeutic-advantage-of-ablative-hypofractionated-radiation-therapy-compared-with-conventional-fractionated-radiation-therapy
#6
Jie Lan, Rui Li, Li-Mei Yin, Lei Deng, Jun Gui, Bao-Qing Chen, Lin Zhou, Mao-Bin Meng, Qiao-Rong Huang, Xian-Ming Mo, Yu-Quan Wei, Bo Lu, Adam Dicker, Jian-Xin Xue, You Lu
PURPOSE: Ablative hypofractionated radiation therapy (AHFRT) presents a therapeutic advantage compared with conventional fractionated radiation therapy (CFRT) for primary and oligometastatic cancers. However, the underlying mechanisms remain largely unknown. In the present study, we compared the immune alterations in response to AHFRT versus CFRT and examined the significance of immune regulations contributing to the efficacy of AHFRT. METHODS AND MATERIALS: We established subcutaneous tumors using syngeneic lung cancer and melanoma cells in both immunocompetent and immunocompromised mice and treated them with AHFRT and CFRT under the same biologically equivalent dose...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29617574/circulating-and-tumor-myeloid-derived-suppressor-cells-in-resectable-non-small-cell-lung-cancer
#7
Yoshikane Yamauchi, Seyer Safi, Carolin Blattner, Anchana Rathinasamy, Ludmila Umansky, Simone Juenger, Arne Warth, Martin Eichhorn, Thomas Muley, Felix J F Herth, Hendrik Dienemann, Michael Platten, Philipp Beckhove, Jochen Utikal, Hans Hoffmann, Viktor Umansky
Rationale Myeloid-derived suppressor cell (MDSC) expansion has been found to play a role in disease progression in cancer patients. However, the characteristics of MDSCs in lung cancer are poorly understood. Objectives We prospectively investigated MDSCs and inflammatory factors in tumor and peripheral blood samples from patients with resectable non-small cell lung cancer (NSCLC) and studied their correlations with the disease prognosis. Methods A complex analysis of MDSC subsets and inflammatory mediators was performed using flow cytometry and a Bio-Plex assay...
April 4, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29614426/plasticity-and-biological-diversity-of-myeloid-derived-suppressor-cells
#8
REVIEW
Kerem Ben-Meir, Nira Twaik, Michal Baniyash
Myeloid derived suppressor cells (MDSCs) are immature myeloid cells characterized by diverse phenotypes and functions. They impair effector functions of immune cells and promote tumor growth, angiogenesis, and tissue damage. In pathologies characterized by chronic inflammation, MDSCs are arrested in their immature state and migrate from the bone marrow to the periphery and to the site of inflammation, where they mediate immunosuppression. When reaching new environments, which exhibit a different array of cytokines, chemokines, and pro-inflammatory mediators, MDSCs sense and adapt to the altered micro-environment by virtue of acquiring different suppressive features/functions that involve changing their cell fate, surface receptors, metabolism and intracellular as well as secreted molecules...
March 31, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29606341/myeloid-derived-suppressors-cells-mdsc-correlate-with-clinicopathologic-factors-and-pathologic-complete-response-pcr-in-patients-with-urothelial-carcinoma-uc-undergoing-cystectomy
#9
REVIEW
Moshe C Ornstein, Claudia Marcela Diaz-Montero, Patricia Rayman, Paul Elson, Samuel Haywood, James H Finke, Jin S Kim, Paul G Pavicic, Marcelo Lamenza, Sarah Devonshire, Priscilla Dann, Kim Schach, Andrew Stephenson, Steven Campbell, Hamid Emamekhoo, Marc S Ernstoff, Christopher J Hoimes, Timothy D Gilligan, Brian I Rini, Jorge A Garcia, Petros Grivas
BACKGROUND: Myeloid derived suppressor cells (MDSC) are heterogeneous immunosuppressive cells with potential predictive and prognostic roles in cancer. The association between MDSC, clinicopathologic factors, and pathologic response in patients with bladder urothelial carcinoma (UC) was explored. METHODS: Peripheral blood or tissue were collected from patients with UC undergoing definitive surgery. MDSCs levels were measured in peripheral blood mononuclear cells and fresh tumor tissue...
March 29, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29600976/impact-of-endostatin-gene-therapy-on-myeloid-derived-suppressor-cells-from-a-metastatic-renal-cell-carcinoma
#10
K C Chaves, E M Costa, L F Teixeira, M H Bellini
AIM: To evaluate the role of endostatin (ES) gene therapy on myeloid-derived suppressor cells (MDSC) in a metastatic model of renal cell carcinoma (RCC). MATERIALS AND METHODS: Balb/C mice bearing orthotopic Renca tumors were treated with NIH/3T3-LendSN or, as a control, with NIH/3T3-LXSN cells. At the end of in vivo experiment, plasma and tissue lung samples were collected. Plasma ES and granulocyte colony stimulating factor (G-CSF) levels were measured by ELISA and Milliplex, respectively...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29572968/implantable-synthetic-immune-niche-for-spatiotemporal-modulation-of-tumor-derived-immunosuppression-and-systemic-antitumor-immunity-postoperative-immunotherapy
#11
Hathaichanok Phuengkham, Chanyoung Song, Soong Ho Um, Yong Taik Lim
The development of biomaterial-based immune niches that can modulate immunosuppressive factors in tumor microenvironment (TME) will be a key technology for improving current cancer immunotherapy. Here, implantable, engineered 3D porous scaffolds are designed to generate synergistic action between myeloid-derived suppressor cell (MDSC)-depleting agents, which can accommodate the establishment of a permissive immunogenic microenvironment to counteract tumor-induced immunosuppression, and cancer vaccines consisting of whole tumor lysates and nanogel-based adjuvants, which can generate tumor antigen-specific T cell responses...
March 23, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29572232/il18-promotes-mdsc-mediated-immunosuppression-in-multiple-myeloma
#12
(no author information available yet)
IL18 drives bone marrow MDSC function to suppress T-cell activity and accelerate multiple myeloma.
March 23, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29563330/cd38-m-mdsc-expansion-characterizes-a-subset-of-advanced-colorectal-cancer-patients
#13
Tatiana A Karakasheva, George A Dominguez, Ayumi Hashimoto, Eric W Lin, Christopher Chiu, Kate Sasser, Jae W Lee, Gregory L Beatty, Dmitry I Gabrilovich, Anil K Rustgi
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a population of immature immune cells with several protumorigenic functions. CD38 is a transmembrane receptor-ectoenzyme expressed by MDSCs in murine models of esophageal cancer. We hypothesized that CD38 could be expressed on MDSCs in human colorectal cancer (CRC), which might allow for a new perspective on therapeutic targeting of human MDSCs with anti-CD38 monoclonal antibodies in this cancer. METHODS: Blood samples were collected from 41 CRC patients and 8 healthy donors, followed by peripheral blood mononuclear cell (PBMC) separation...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29563123/murine-cmv-induces-type-1-ifn-that-impairs-differentiation-of-mdscs-critical-for-transplantation-tolerance
#14
Anil Dangi, Lei Zhang, Xiaomin Zhang, Xunrong Luo
Clinical tolerance without immunosuppression has now been achieved for organ transplantation, and its scope will likely continue to expand. In this context, a previously understudied and now increasingly relevant area is how microbial infections might affect the efficacy of tolerance. A highly prevalent and clinically relevant posttransplant pathogen is cytomegalovirus (CMV). Its impact on transplantation tolerance and graft outcomes is not well defined. Employing a mouse model of CMV (MCMV) infection and allogeneic pancreatic islet transplantation in which donor-specific tolerance was induced by infusing donor splenocytes rendered apoptotic by treatment with ethylenecarbodiimide, we investigated the effect of CMV infection on transplantation tolerance induction...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29556233/s100a4-protects-myeloid-derived-suppressor-cells-from-intrinsic-apoptosis-via-tlr4-erk1-2-signaling
#15
Qingcui Li, Chengliang Dai, Rui Xue, Peigang Wang, Lin Chen, Yijie Han, Ulrike Erben, Zhihai Qin
Myeloid-derived suppressor cells (MDSCs) often expand during cancer or chronic inflammation and dampen immune responses. However, mechanisms underlying their capacity to escape intrinsic apoptosis in the inflammatory environment are still largely unknown. In this study, we investigated this in mouse tumor models with MDSC accumulation. Spontaneous rejection of tumors implanted into mice deficient for the small Ca2+ -binding protein S100A4 (S100A4-/- ) was accompanied by low numbers of peripheral MDSCs. This was independent of S100A4 expression on tumor cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29555056/myeloid-derived-suppressor-cells-accumulate-among-myeloid-cells-contributing-to-tumor-growth-in-matrix-metalloproteinase-12-knockout-mice
#16
Jiangchao Li, Xiaohan Zhang, Qing Liu, Mingming Yang, Zijun Zhou, Yuxiang Ye, Zeqi Zhou, Xiaodong He, Lijing Wang
Myeloid-derived suppressor cells (MDSCs) are found frequently in patients and mice bearing tumors, which derived from immature myeloid cells. In healthy individuals, immature myeloid cells formed in the bone marrow differentiating to dendritic cells, macrophages and neutrophils. However, it is unclear whether some gene deficiency will lead to MDSCs accumulation in mice without bearing tumor. Here, we observed that MDSCs accumulated in the bone marrow of matrix metalloproteinase 12 knockout mice (MMP12-/- mice) compared with wild type mice (MMP12+/+ mice)...
December 13, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29552012/targeting-myeloid-derived-suppressor-cells-to-bypass-tumor-induced-immunosuppression
#17
REVIEW
Viktor Fleming, Xiaoying Hu, Rebekka Weber, Vasyl Nagibin, Christopher Groth, Peter Altevogt, Jochen Utikal, Viktor Umansky
The immune system has many sophisticated mechanisms to balance an extensive immune response. Distinct immunosuppressive cells could protect from excessive tissue damage and autoimmune disorders. Tumor cells take an advantage of those immunosuppressive mechanisms and establish a strongly immunosuppressive tumor microenvironment (TME), which inhibits antitumor immune responses, supporting the disease progression. Myeloid-derived suppressor cells (MDSC) play a crucial role in this immunosuppressive TME. Those cells represent a heterogeneous population of immature myeloid cells with a strong immunosuppressive potential...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29547768/plasticity-of-myeloid-derived-suppressor-cells-in-cancer
#18
REVIEW
Evgenii Tcyganov, Jerome Mastio, Eric Chen, Dmitry I Gabrilovich
In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC). PMN-MSDC share phenotypic and morphologic features with neutrophils, whereas M-MDSC are similar to monocytes and are characterized by high plasticity...
March 13, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29544121/myeloid-derived-suppressor-cells-their-role-in-cancer-and-obesity
#19
REVIEW
Suzanne Ostrand-Rosenberg
Myeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity...
March 12, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29543758/characterization-of-multiple-cytokine-combinations-and-tgf-%C3%AE-on-differentiation-and-functions-of-myeloid-derived-suppressor-cells
#20
Cho-Rong Lee, Wongeun Lee, Steve K Cho, Sung-Gyoo Park
Myeloid-derived suppressor cells (MDSCs) regulate T cell immunity, and this population is a new therapeutic target for immune regulation. A previous study showed that transforming growth factor-β (TGF-β) is involved in controlling MDSC differentiation and immunoregulatory function in vivo. However, the direct effect of TGF-β on MDSCs with various cytokines has not previously been tested. Thus, we examined the effect of various cytokine combinations with TGF-β on MDSCs derived from bone marrow cells. The data show that different cytokine combinations affect the differentiation and immunosuppressive functions of MDSCs in different ways...
March 15, 2018: International Journal of Molecular Sciences
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