keyword
MENU ▼
Read by QxMD icon Read
search

mdsc

keyword
https://www.readbyqxmd.com/read/29436696/cxcr4-receptor-blockage-reduces-the-contribution-of-tumor-and-stromal-cells-to-the-metastatic-growth-in-the-liver
#1
Aitor Benedicto, Irene Romayor, Beatriz Arteta
The liver is a common site for the metastatic spread of primary malignancies including colorectal cancer, and liver metastasis is a main cause of death in cancer patients. This is due to the complexity of the interactions taking place in the liver between tumor and stromal cells. In fact, cancer‑associated fibroblasts (CAFs) have been shown to support tumor growth through the CXCL12/CXCR4 axis. However, along with cancer cells, myeloid‑derived suppressor cells (MDSCs), immature dendritic cells with immunosuppressive potential, also express CXCR4...
February 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29418061/platelets-couple-inflammation-to-tumorigenesis-a-bridge-too-far
#2
Matthew J Flick, Joseph S Palumbo
Platelets were first implicated in the pathogenesis of cancer and inflammatory pathologies decades ago, but an understanding of the mechanisms coupling platelet function to cancer progression is still a work in progress. In their paper, Servais et al. push the field forward by illustrating that platelets represent a crucial link between inflammatory disease and tumorigenesis [1]. This interesting paper presents data showing that platelets promote intestinal tumorigenesis in the context of inflammatory colitis by supporting the recruitment and/or expansion of myeloid-derived suppressor cells (MDSCs)...
February 8, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29416921/inhibition-of-rac-family-protein-impairs-colitis-and-colitis-associated-cancer-in-mice
#3
Yandong Guo, Jing Xiong, Jing Wang, Jing Wen, Fachao Zhi
The prevalence of inflammatory bowel disease (IBD) has increased worldwide and IBD has been demonstrated to promote the development of colorectal cancer. The Rac family of proteins are involved in key mitogenic pathways. However, to the best of our knowledge, no prior studies have investigated the expression and role of Rac on colitis and colitis-associated cancer (CAC). In the current study, Rac expression in patients with colitis was analyzed according to the expression value from NCBI GEO database (GDS3268)...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29414309/the-role-of-carboxyl-group-of-pressure-sensitive-adhesive-in-controlled-release-of-propranolol-in-transdermal-patch-quantitative-determination-of-ionic-interaction-and-molecular-mechanism-characterization
#4
Degong Yang, Xiaocao Wan, Peng Quan, Chao Liu, Liang Fang
Acrylic pressure sensitive adhesives (PSAs) are widely used in transdermal drug delivery system (TDDS). However, there was little research about the quantitative relationship between drug release and drug-PSAs interaction. In this study, five acrylic PSAs with different molar fraction of carboxyl group were designed and synthesized. Propranolol (PRO) was used as model drug to evaluate release profiles in the PSAs in vitro and in vivo. The drug release percent in the PSAs were 81.66, 78.22, 51.66, 21.81 and 11...
January 29, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29413890/indoleamine-2-3-dioxygenase-and-its-therapeutic-inhibition-in-cancer
#5
George C Prendergast, William J Malachowski, Arpita Mondal, Peggy Scherle, Alexander J Muller
The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization, and metastasis. IDO1 suppresses local CD8+ T effector cells and natural killer cells and induces CD4+ T regulatory cells (iTreg) and myeloid-derived suppressor cells (MDSC). The structurally distinct enzyme tryptophan dioxygenase (TDO) also has been implicated recently in immune escape and metastatic progression. Lastly, emerging evidence suggests that the IDO1-related enzyme IDO2 may support IDO1-mediated iTreg and contribute to B-cell inflammed states in certain cancers...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29399399/bromodomain-inhibition-exerts-its-therapeutic-potential-in-malignant-pleural-mesothelioma-by-promoting-immunogenic-cell-death-and-changing-the-tumor-immune-environment
#6
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomatà, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio, Riccardo Taulli
Systemic treatment of malignant pleural mesothelioma (MPM) is moderately active for the intrinsic pharmacological resistance of MPM cell and its ability to induce an immune suppressive environment. Here we showed that the expression of bromodomain (BRD) proteins BRD2, BRD4 and BRD9 was significantly higher in human primary MPM cells compared to normal mesothelial cells (HMC). Nanomolar concentrations of bromodomain inhibitors (BBIs) JQ1 or OTX015 impaired patient-derived MPM cell proliferation and induced cell-cycle arrest without affecting apoptosis...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29386427/-the-immunosuppressive-function-of-myeloid-derived-suppressor-cells-is-regulated-by-the-hmgb1-tlr4-axis
#7
Masashi Tachibana
 Myeloid-derived suppressor cells (MDSCs) accumulate under pathological conditions, including cancer and chronic inflammation, and they suppress various immune responses such as T cell proliferation. Although several inflammatory signals enhance the differentiation and/or function of MDSCs, it is not clear which factors regulate their differentiation and immunosuppressive function. It has been highlighted that damage-associated molecular patterns (DAMPs) play important roles in the induction of inflammation...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29383101/cxcr2-mdscs-promote-breast-cancer-progression-by-inducing-emt-and-activated-t-cell-exhaustion
#8
Ha Zhu, Yan Gu, Yiquan Xue, Ming Yuan, Xuetao Cao, Qiuyan Liu
Although myeloid-derived suppressor cells (MDSCs) have been demonstrated to contribute to tumor initiation, progression and metastasis, however, which MDSC subsets are preferentially expanded and activated, and what's the key molecular mechanism responsible for specific MDSC subsets in promoting tumor progression need to be fully addressed. Here we identify that Ly6GmiLy6CloCD11b+CXCR2+ subpopulation (named CXCR2+ MDSCs) are predominately expanded and recruited in systemic and local tumor microenvironment during breast cancer progression and metastasis...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382420/-blood-extracts-from-pilose-antler-changes-the-proportion-of-immune-cells-in-mammary-tumor-bearing-mice-and-inhibit-the-growth-of-transplanted-tumor
#9
Chenghao Fu, Chunying Jiang, Kexin Zheng, Shiliang Ma
Objective To study the influence of blood extracts from pilose antler on the immune system in healthy mice and tumor-bearing mice. Methods A mouse mammary tumor transplantation model was established and both the healthy and the tumor-bearing mice were gavaged with the blood extracts of pilose antler. The percentages of mouse peripheral blood CD3+ T cells, CD4+ T cells, CD8+ T cells, B220+ B cells and myeloid-derived suppressor cells (MDSCs) in the healthy and tumor-bearing mice were analyzed by flow cytometry...
December 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29374065/metformin-induced-reduction-of-cd39-and-cd73-blocks-myeloid-derived-suppressor-cell-activity-in-patients-with-ovarian-cancer
#10
Yi Zhang, Lifeng Li, Liping Wang, Jieyao Li, Zhirui Fan, Li Yang, Zhen Zhang, Chaoqi Zhang, Dongli Yue, Guohui Qin, Tengfei Zhang, Feng Li, Xinfeng Chen, Yu Ping, Dan Wang, Qun Gao, Qianyi He, Lan Huang, Hong Li, Jianmin Huang, Xuan Zhao, Wenhua Xue, Zhi Sun, Jingli Lu, Jane Yu, Jie Zhao, Bin Zhang
Metformin is a broadlyprescribed drug for type 2 diabetes that exerts antitumor activity, yet the mechanisms underlying this activity remain unclear. We show here that metformin treatment blocks the suppressive function of myeloid-derived suppressor cells (MDSC) in patients with ovarian cancer (OC) by downregulating the expression and ectoenzymatic activity of CD39 and CD73 on monocytic and polymononuclear MDSC subsets. Metformin triggered activation of AMP-activated protein kinase α (AMPKα) and subsequently suppressed hypoxia-inducible factor-α (HIF-1α), which was critical for induction of CD39/CD73 expression in MDSC...
January 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29363526/nitric-oxide-production-by-myeloid-derived-suppressor-cells-plays-a-role-in-impairing-fc-receptor-mediated-natural-killer-cell-function
#11
Andrew Stiff, Prashant Trikha, Bethany L Mundy-Bosse, Elizabeth L McMichael, Thomas A Mace, Brooke Benner, Kari Kendra, Amanda Campbell, Shalini Gautam, David Abood, Ian Landi, Vincent Hsu, Megan C Duggan, Robert Wesolowski, Matthew Old, John H Howard, Lianbo Yu, Nancy Stasik, Thomas Olencki, Natarajan Muthusamy, Susheela Tridandapani, John C Byrd, Michael A Caligiuri, William E Carson
PURPOSE: Monoclonal antibodies (mAb) are used to treat solid and hematological malignancies, and work in part through Fc receptors (FcR) on natural killer cells (NK). However, FcR mediated functions of NK cells from cancer patients are significantly impaired. Identifying the mechanisms of this dysfunction and impaired response to mAb therapy could lead to combination therapies and enhance mAb therapy.  Experimental Design: Co-cultures of autologous NK cells and MDSC from cancer patients were used to study the effect of MDSC on NK cell FcR mediated functions including antibody dependent cellular cytotoxicity, cytokine production, and signal transduction in vitro...
January 23, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29357251/salutaxel-a-conjugate-of-docetaxel-and-a-muramyl-dipeptide-mdp-analogue-acts-as-multi-functional-prodrug-that-inhibits-tumor-cell-growth-and-metastasis
#12
Xiaoming Wen, Purong Zheng, Yao Ma, Yingye Ou, Weixin Huang, Shuo Li, Shoujia Liu, Xuan Zhang, Ziyu Wang, Qianli Zhang, Wenming Cheng, Ruwen Lin, Hongzu Li, Youyou Cai, Chunyun Hu, Ningbin Wu, Long Wan, Tingting Pan, Jinlong Yao, Xuelu Bei, Wei-Bin Wu, Jian Jin, Jie Yan, Gang Liu
Salutaxel (3) is a conjugate of docetaxel (7) and a muramyl dipeptide (MDP) analogue. Docetaxel (7) has been recognized as a highly active chemotherapeutic agent against various cancers. MDP and its ana-logues are powerful potentiators of the anti-tumor actions of various tumor-necrotizing agents. This arti-cle documents the discovery of compound 3 and presents pharmacological proof of its biological func-tion in tumor-bearing mice. Drug candidate 3 was superior to compound 7 in its ability to prevent tumor growth and metastasis...
January 22, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#13
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
INTRODUCTION: Post Vasectomy Pain Syndrome (PVPS) is an uncommon urologic problem that remains a challenge to manage. We aim to evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for PVPS at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon from March 2002 to October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients and success was defined as NRS ≤1 for >4 hours...
January 20, 2018: BJU International
https://www.readbyqxmd.com/read/29345358/editorial-two-mdsc-faces-in-obesity-correcting-metabolic-dysfunctions-but-promoting-tumor-development
#14
EDITORIAL
Viktor Fleming, Viktor Umansky
No abstract text is available yet for this article.
December 15, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345342/high-fat-diet-and-leptin-promote-tumor-progression-by-inducing-myeloid-derived-suppressor-cells
#15
Virginia K Clements, Tiha Long, Ramses Long, Chas Figley, Daniel M C Smith, Suzanne Ostrand-Rosenberg
Obesity is a risk factor for cancer incidence and cancer mortality. The association of obesity and cancer is attributed to multiple factors, but the tightest linkage is with the chronic, low-grade inflammation that accompanies obesity. Myeloid-derived suppressor cells (MDSC) are known facilitators of cancer progression that act by suppressing the activation and function of tumor-reactive T cells. Because MDSC quantity and function are driven by chronic inflammation, we hypothesized that MDSC may accumulate in obese individuals and facilitate tumor growth by suppressing antitumor immunity...
January 3, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345064/tlr8-ligation-induces-apoptosis-of-monocytic-myeloid-derived-suppressor-cells
#16
Yushe Dang, Zina J Rutnam, Gregory Dietsch, Hailing Lu, Yi Yang, Robert Hershberg, Mary L Disis
Myeloid-derived suppressor cells (MDSCs) accumulate in tumors and the peripheral blood of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A limited number of agents are known to impact MDSC activity. TLR8 is expressed in myeloid cells. We investigated expression of TLR8 on MDSC and the effect of a TLR8 agonist, motolimod, on MDSC survival and function. TLR8 was highly expressed in monocytic MDSC (mMDSC) but absent in granulocytic MDSC (gMDSC). Treatment of human PBMC with motolimod reduced the levels of mMDSC in volunteers and cancer donors versus control (P < 0...
January 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29343444/activation-of-p53-in-immature-myeloid-precursor-cells-controls-differentiation-into-ly6c-cd103-monocytic-antigen-presenting-cells-in-tumors
#17
Madhav D Sharma, Paulo C Rodriguez, Brent H Koehn, Babak Baban, Yan Cui, Gang Guo, Michiko Shimoda, Rafal Pacholczyk, Huidong Shi, Eun-Joon Lee, Hongyan Xu, Theodore S Johnson, Yukai He, Taha Mergoub, Christopher Venable, Vincenzo Bronte, Jedd D Wolchok, Bruce R Blazar, David H Munn
CD103+ dendritic cells are critical for cross-presentation of tumor antigens. Here we have shown that during immunotherapy, large numbers of cells expressing CD103 arose in murine tumors via direct differentiation of Ly6c+ monocytic precursors. These Ly6c+CD103+ cells could derive from bone-marrow monocytic progenitors (cMoPs) or from peripheral cells present within the myeloid-derived suppressor cell (MDSC) population. Differentiation was controlled by inflammation-induced activation of the transcription factor p53, which drove upregulation of Batf3 and acquisition of the Ly6c+CD103+ phenotype...
January 16, 2018: Immunity
https://www.readbyqxmd.com/read/29340117/the-regulation-of-pre-metastatic-niche-formation-by-neutrophils
#18
REVIEW
Jadwiga Jablonska, Stephan Lang, Ronit Vogt Sionov, Zvi Granot
Metastasis is a multistep process requiring tumor cell detachment from the primary tumor and migration to target organs through the lymphatic or blood circulatory systems. Specific organs are predisposed to metastases in certain cancers and the formation of supportive metastatic microenvironment determines tumor cell homing. Such an environment is provided by a pre-metastatic niche that is formed through the recruitment of bone marrow-derived myeloid cells, however the mechanisms of its formation are not fully understood...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340095/tumoral-immune-infiltrate-if-pd-l1-expression-and-role-of-cd8-tia-1-lymphocytes-in-localized-osteosarcoma-patients-treated-within-protocol-isg-os1
#19
Emanuela Palmerini, Claudio Agostinelli, Piero Picci, Stefano Pileri, Teresa Marafioti, Pier-Luigi Lollini, Katia Scotlandi, Alessandra Longhi, Maria Serena Benassi, Stefano Ferrari
Background: We hypothesized that immune-infiltrates were associated with superior survival, and examined a primary osteosarcoma tissue microarrays (TMAs) to test this hypothesis. Methods: 129 patients (pts) with localized osteosarcoma treated within protocol ISG-OS1 were included in the study. Clinical characteristics, expression of CD8, CD3, FOXP3, CD20, CD68/CD163 (tumor associated macrophage, TAM), Tia-1 (cytotoxic T cell), CD303 (plasmacytoid dendritic cells: pDC), Arginase-1 (myeloid derived suppressor cells: MDSC), PD-1 on immune-cells (IC), and PD-L1 on tumoral cells (TC) and IC were analysed and correlated with outcome...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340089/lncrna-rncr3-promotes-chop-expression-by-sponging-mir-185-5p-during-mdsc-differentiation
#20
Wencong Shang, Zhenzhen Tang, Yunhuan Gao, Houbao Qi, Xiaomin Su, Yuan Zhang, Rongcun Yang
Myeloid-derived suppressor cells (MDSCs) play a critical role in regulating immune responses in cancer and other pathological conditions. Mechanism(s) regulating MDSC differentiation and function is not completely clear, especially epigenetic regulation. In this study, we found that MDSCs express retinal non-coding RNA3 (RNCR3), and the expression in MDSCs is upregulated by inflammatory and tumor associated factors. RNCR3 may function as a competing endogenous RNA (ceRNA) to promote Chop expression by sponging miR-185-5p during MDSC differentiation...
December 19, 2017: Oncotarget
keyword
keyword
10028
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"