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https://www.readbyqxmd.com/read/28092472/using-biomarkers-to-predict-and-to-prevent-cardiotoxicity-of-cancer-therapy
#1
Daniela Cardinale, Gina Biasillo, Michela Salvatici, Maria Teresa Sandri, Carlo Maria Cipolla
Cardiotoxicity is a common complication that may compromise the clinical effectiveness of anticancer therapy. The current standard for monitoring cardiac function detects cardiotoxicity only when a functional impairment has already occurred, not allowing for any early preventive strategy. Areas covered: A novel approach, based on the use of biomarkers has recently emerged, resulting in a very effective tool for early, real-time identification, and monitoring of cardiotoxicity. In particular, cardiac troponin elevation during chemotherapy allows to identify patients more prone to develop myocardial dysfunction and cardiac events...
January 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28065839/cardiovascular-function-in-long-term-hematopoietic-cell-transplantation-survivors
#2
Saro H Armenian, David Horak, Jessica M Scott, George Mills, Aida Siyahian, Jennifer Berano Teh, Pamela S Douglas, Stephen J Forman, Smita Bhatia, Lee W Jones
Peak oxygen consumption (VO2peak), as measured by cardiopulmonary exercise testing (CPET), is a powerful independent predictor of cardiovascular disease (CVD) and all-cause mortality in a broad range of populations. We assessed the safety and feasibility of CPET in aging long-term HCT survivors, a population at high risk for premature-onset of CVD. Next we examined how organ-specific impairments (e.g. cardiac, pulmonary, hematologic) impact VO2peak after HCT. Twenty consecutive HCT survivors underwent a comprehensive assessment of cardiopulmonary health that included CPET, echocardiography with strain, pulmonary function testing, six-minute walk test, and timed-up and go...
January 5, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28063262/quantification-of-mechanical-dyssynchrony-in-growth-restricted-fetuses-and-normal-controls-using-speckle-tracking-echocardiography-ste
#3
Kristina Krause, Mareike Möllers, Kerstin Hammer, Maria Karina Falkenberg, Ute Möllmann, Dennis Görlich, Walter Klockenbusch, Ralf Schmitz
PURPOSE: To evaluate longitudinal mechanical dyssynchrony in normally grown fetuses by speckle tracking echocardiography (STE) and to compare longitudinal mechanical dyssynchrony in fetal growth restriction (FGR) with normal controls. MATERIALS AND METHODS: A prospective study was performed on 30 FGR and 62 normally grown fetuses, including 30 controls matched by gestational age, using STE and a transversal four-chamber view. Data analysis was carried out with a high frame rate of about 175 frames/s...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28062567/short-term-high-fat-diet-compromises-myocardial-function-a-radial-strain-rate-imaging-study
#4
Julien Ternacle, Feng Wan, Daigo Sawaki, Mathieu Surenaud, Maria Pini, Raquel Mercedes, Laura Ernande, Etienne Audureau, Jean-Luc Dubois-Rande, Serge Adnot, Sophie Hue, Gabor Czibik, Genevieve Derumeaux
AIM: Long-term high-fat diet (HFD) induces both cardiac remodelling and myocardial dysfunction in murine models. The aim was to assess the time course and mechanisms of metabolic and cardiac modifications induced by short-term HFD in wild-type (WT) mice. METHODS AND RESULTS: Thirty-three WT mice were subjected to HFD (60% fat, n = 16) and chow diet (CD, 13% fat, n = 17). Metabolic and echocardiographic data were collected at baseline and every 5 weeks for 20 weeks...
January 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28060997/effect-of-hypercholesterolemia-on-myocardial-function-ischemia-reperfusion-injury-and-cardioprotection-by-preconditioning-postconditioning-and-remote-conditioning
#5
REVIEW
Ioanna Andreadou, Efstathios K Iliodromitis, Antigone Lazou, Anikó Görbe, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy
Hypercholesterolemia is considered to be a principle risk factor for cardiovascular disease, having direct negative effects on the myocardium itself, in addition to the development of atherosclerosis. Since hypercholesterolemia affects global cardiac gene expression profile, among many other factors, increased myocardial oxidative stress, mitochondrial dysfunction and inflammation trigger apoptosis and this may account for myocardial dysfunction and increased susceptibility of the myocardium to infarction. In addition, numerous experimental and clinical studies revealed that hyperlcholesterolemia may interfere with the cardioprotective potential of conditioning mechanisms...
January 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28054208/is-2d-speckle-tracking-echocardiography-useful-for-detecting-and-monitoring-myocardial-dysfunction-in-adult-m-3243a-g-carriers-a-retrospective-pilot-study
#6
S Koene, J Timmermans, G Weijers, P de Laat, C L de Korte, J A M Smeitink, M C H Janssen, L Kapusta
OBJECTIVES: Cardiomyopathy is a common complication of mitochondrial disorders, associated with increased mortality. Two dimensional speckle tracking echocardiography (2DSTE) can be used to quantify myocardial deformation. Here, we aimed to determine the usefulness of 2DSTE in detecting and monitoring subtle changes in myocardial dysfunction in carriers of the 3243A>G mutation in mitochondrial DNA. METHODS: In this retrospective pilot study, 30 symptomatic and asymptomatic carriers of the mitochondrial 3243A>G mutation of whom two subsequent echocardiograms were available were included...
January 4, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28053087/targeting-traf3ip2-by-genetic-and-interventional-approaches-inhibits-ischemia-reperfusion-induced-myocardial-injury-and-adverse-remodeling
#7
John M Erikson, Anthony J Valente, Srinivas Mummidi, Hemanthkumar Kandikattu, Vincent G DeMarco, Shawn B Bender, William P Fay, Ulrich Siebenlist, Bysani Chandrasekar
Re-establishing blood supply is the primary goal for reducing myocardial injury in subjects with ischemic heart disease. Paradoxically, reperfusion results in oxidative stress and a marked inflammatory response in the heart. TRAF3IP2 (TRAF3 Interacting Protein 2; previously known as CIKS or Act1) is an oxidative stress-responsive cytoplasmic adapter molecule that is an upstream regulator of both IκB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an important mediator of autoimmune and inflammatory responses...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28040191/left-ventricular-function-in-children-and-adolescents-with-arrhythmogenic-right-ventricular-cardiomyopathy
#8
Paweena Chungsomprasong, Robert Hamilton, Wietske Luining, Meena Fatah, Shi-Joon Yoo, Lars Grosse-Wortmann
The aim of this study was to determine if left ventricular (LV) contractility is reduced in children with arrhythmogenic right ventricular cardiomyopathy (ARVC). For this retrospective study, children and adolescents undergoing a workup for ARVC were characterized according to the revised Task Force Criteria (rTFC). LV strain, rotation, and torsion were measured by feature-tracking cardiovascular magnetic resonance imaging (CMR). Of 142 pediatric patients, 41% had no, 23% possible, 20% borderline, and 16% definite ARVC...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28039400/left-ventricular-endocardial-and-epicardial-strain-changes-with-apical-myocardial-ischemia-in-an-open-chest-porcine-model
#9
Kimberly Howard-Quijano, Melissa McCabe, Alexander Cheng, Wei Zhou, Kentaro Yamakawa, Einat Mazor, Jennifer C Scovotti, Aman Mahajan
Early detection of acute myocardial ischemia is critical to prevent permanent myocardial damage. The impact of apical ischemia on global left ventricular (LV) function can be difficult to characterize using traditional volume-based echocardiography measures. Myocardial strain imaging is a sensitive, quantitative marker of myocardial deformation that can measure ventricular function. Recent advances allow layer-specific measurement of endo- and epicardial strain, enhancing the ability to evaluate myocardial ischemia...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28033581/irhom2-is-involved-in-lipopolysaccharide-induced-cardiac-injury-in-vivo-and-in-vitro-through-regulating-inflammation-response
#10
Xue-Li Lu, Cui-Hua Zhao, Han Zhang, Xin-Liang Yao
Heart is a complex assembly of many cell types constituting of myocardium, endocardium and epicardium that intensively communicate to each other in order to maintain the proper cardiac function. Previous research has demonstrated that lipopolysaccharide (LPS) can induce myocardial dysfunction. iRhom2 is encoded by the gene Rhbdf2, regulating inflammation via tumor necrosis factor-α (TNF-α). In this study, we attempted to investigate the role of iRhom2 in LPS-induced cardiac injury and clarify the potential mechanism...
December 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28032633/estrogen-receptors-%C3%AE-and-%C3%AE-play-major-roles-in-ethanol-evoked-myocardial-oxidative-stress-and-dysfunction-in-conscious-ovariectomized-rats
#11
Fanrong Yao, Abdel A Abdel-Rahman
BACKGROUND: We documented the dependence of ethanol (EtOH)-evoked myocardial dysfunction on estrogen (E2 ), and our recent estrogen receptor (ER) blockade study, in proestrus rats, implicated ERα signaling in this phenomenon. However, a limitation of selective pharmacological loss-of-function approach is the potential contribution of the other 2 ERs to the observed effects because crosstalk exists between the 3 ERs. Here, we adopted a "regain"-of-function approach (using selective ER subtype agonists) to identify the ER subtype(s) required for unraveling the E2 -dependent myocardial oxidative stress/dysfunction caused by EtOH in conscious ovariectomized (OVX) rats...
December 29, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28005512/cardiac-mr-imaging-in-acute-coronary-syndrome-application-and-image-interpretation
#12
Farhood Saremi
Acute coronary syndrome (ACS) is a frequent cause of hospitalization and coronary interventions. Cardiac magnetic resonance (MR) imaging is an increasingly used technique for initial work-up of chest pain and early post-reperfusion and follow-up evaluation of ACS to identify patients at high risk of further cardiac events. Cardiac MR imaging can evaluate with accuracy a variety of prognostic indicators of myocardial damage, including regional myocardial dysfunction, infarct distribution, infarct size, myocardium at risk, microvascular obstruction, and intramyocardial hemorrhage in both acute setting and later follow-up examinations...
January 2017: Radiology
https://www.readbyqxmd.com/read/27999826/the-diagnosis-of-silent-myocardial-ischemia-motion-frozen-or-morphing-myocardial-perfusion-imaging
#13
EDITORIAL
Cheng Chang, Bo Ye, Wenhui Xie, Daoliang Zhang, Bei Lei, Xiaodan Ye
Silent myocardial ischemia is typically defined as objective evidence of myocardial ischemia in patients without subjective ischemia symptoms. Currently, coronary artery angiography is the gold standard for diagnosis of asymptomatic coronary artery disease (CAD). Computed tomography coronary angiography (CTCA) can visually demonstrate the morphology, trend and extent of coronary stenosis and is commonly used in clinical screening of CAD. Myocardial perfusion imaging can be used not only to identify whether anatomical stenosis causes myocardial dysfunction, but to also assess the risk stratification and prognosis of myocardial disease (MD)...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27999547/myocardial-contractile-dysfunction-is-present-without-histopathology-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2f-and-is-prevented-after-claudin-5-virotherapy
#14
Nima Milani-Nejad, Eric J Schultz, Jessica L Slabaugh, Paul M L Janssen, Jill A Rafael-Fortney
Mutations in several members of the dystrophin glycoprotein complex lead to skeletal and cardiomyopathies. Cardiac care for these muscular dystrophies consists of management of symptoms with standard heart medications after detection of reduced whole heart function. Recent evidence from both Duchenne muscular dystrophy patients and animal models suggests that myocardial dysfunction is present before myocardial damage or deficiencies in whole heart function, and that treatment prior to heart failure symptoms may be beneficial...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27976640/cardiac-functions-assessment-in-children-with-celiac-disease-and-its-correlation-with-the-degree-of-mucosal-injury-doppler-tissue-imaging-study
#15
Abeer Fathy, Hany M Abo-Haded, Najat Al-Ahmadi, Marwa M El-Sonbaty
BACKGROUND/AIMS: Celiac disease (CD)-associated cardiologic disorders is a growing concern. However, data regarding cardiac affection in children with CD are few. This study aimed at assessing the subclinical impact of CD on the global myocardial performance in Saudi children with CD using Doppler tissue imaging (DTI). PATIENTS AND METHODS: Conventional two-dimensional echocardiography was performed among 20 Saudi children with CDas well as 20 age and sex-matched healthy controls...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27973394/abnormal-mitochondrial-camp-pka-signaling-is-involved-in-sepsis-induced-mitochondrial-and-myocardial-dysfunction
#16
Remi Neviere, Florian Delguste, Arthur Durand, Jocelyn Inamo, Eric Boulanger, Sebastien Preau
Adrenergic receptors couple to Gs-proteins leading to transmembrane adenylyl cyclase activation and cytosolic cyclic adenosine monophosphate (cAMP) production. Cyclic AMP is also produced in the mitochondrial matrix, where it regulates respiration through protein kinase A (PKA)-dependent phosphorylation of respiratory chain complexes. We hypothesized that a blunted mitochondrial cAMP-PKA pathway would participate in sepsis-induced heart dysfunction. Adult male mice were subjected to intra-abdominal sepsis. Mitochondrial respiration of cardiac fibers and myocardial contractile performance were evaluated in response to 8Br-cAMP, PKA inhibition (H89), soluble adenylyl cyclase inhibition (KH7), and phosphodiesterase inhibition (IBMX; BAY60-7550)...
December 10, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27956001/relation-of-functional-status-to-risk-of-development-of-atrial-fibrillation
#17
Satish Ramkumar, Hong Yang, Ying Wang, Mark Nolan, Kazuaki Negishi, Prashanthan Sanders, Thomas Hugh Marwick
Identifying patients at risk is now important as there are demonstrable ways to alter disease progression which could potentially prevent atrial fibrillation (AF) and its complications. We sought whether impaired functional capacity was associated with risk of AF, independent of myocardial dysfunction. In this community-based study, asymptomatic participants aged ≥65 years were recruited if they had ≥1 risk factor (e.g., hypertension, diabetes mellitus, and obesity). Participants underwent baseline echocardiography (including measurement of myocardial mechanics) and six-minute walk test...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27941647/the-role-of-erk1-2-in-the-development-of-diabetic-cardiomyopathy
#18
REVIEW
Zheng Xu, Jian Sun, Qian Tong, Qian Lin, Lingbo Qian, Yongsoo Park, Yang Zheng
Diabetes mellitus is a chronic metabolic condition that affects carbohydrate, lipid and protein metabolism and may impair numerous organs and functions of the organism. Cardiac dysfunction afflicts many patients who experience the oxidative stress of the heart. Diabetic cardiomyopathy (DCM) is one of the major complications that accounts for more than half of diabetes-related morbidity and mortality cases. Chronic hyperglycemia and hyperlipidemia from diabetes mellitus cause cardiac oxidative stress, endothelial dysfunction, impaired cellular calcium handling, mitochondrial dysfunction, metabolic disturbances, and remodeling of the extracellular matrix, which ultimately lead to DCM...
December 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27925013/myocardial-dysfunction-in-children-with-intrauterine-growth-restriction-an-echocardiographic-study
#19
Katarzyna Niewiadomska-Jarosik, Justyna Zamojska, Agata Zamecznik, Agnieszka Wosiak, Piotr Jarosik, Jerzy Stańczyk
INTRODUCTION: The prevalence of intrauterine growth restriction (IUGR) is about 3-10% of live-born newborns and can be as high as 20% in developing countries. It may result in the occurrence of cardiovascular diseases later in life. METHODS: The aim of this study was echocardiographic evaluation, with the use of conventional and tissue Doppler parameters, of cardiac function in children born with IUGR, and comparison with healthy peers born as normally grown foetuses...
December 7, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27908343/a%C3%AE-amyloid-pathology-affects-the-hearts-of-patients%C3%A2-with%C3%A2-alzheimer-s-disease-mind%C3%A2-the-heart
#20
Luca Troncone, Marco Luciani, Matthew Coggins, Elissa H Wilker, Cheng-Ying Ho, Kari Elise Codispoti, Matthew P Frosch, Rakez Kayed, Federica Del Monte
BACKGROUND: Individually, heart failure (HF) and Alzheimer's disease (AD) are severe threats to population health, and their potential coexistence is an alarming prospect. In addition to sharing analogous epidemiological and genetic profiles, biochemical characteristics, and common triggers, the authors recently recognized common molecular and pathological features between the 2 conditions. Whereas cognitive impairment has been linked to HF through perfusion defects, angiopathy, and inflammation, whether patients with AD present with myocardial dysfunction, and if the 2 conditions bear a common pathogenesis as neglected siblings are unknown...
December 6, 2016: Journal of the American College of Cardiology
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