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https://www.readbyqxmd.com/read/28924131/takotsubo-like-myocardial-dysfunction-in-a-patient-with-botulism
#1
Shuichi Tonomura, Yoshiaki Kakehi, Masatoshi Sato, Yuki Naito, Hisao Shimizu, Yasunobu Goto, Nobuyuki Takahashi
Botulinum toxin A (BTXA) can disrupt the neuromuscular and autonomic functions. We herein report a case of autonomic system dysfunction that manifested as Takotsubo-like myocardial dysfunction in a patient with botulism. Takotsubo syndrome results in acute cardiac insufficiency, another fatal complication of botulism in addition to respiratory muscle paralysis, particularly in patients with cardiovascular disease.
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28912187/pediatric-cardiomyopathies
#2
REVIEW
Teresa M Lee, Daphne T Hsu, Paul Kantor, Jeffrey A Towbin, Stephanie M Ware, Steven D Colan, Wendy K Chung, John L Jefferies, Joseph W Rossano, Chesney D Castleberry, Linda J Addonizio, Ashwin K Lal, Jacqueline M Lamour, Erin M Miller, Philip T Thrush, Jason D Czachor, Hiedy Razoky, Ashley Hill, Steven E Lipshultz
Pediatric cardiomyopathies are rare diseases with an annual incidence of 1.1 to 1.5 per 100 000. Dilated and hypertrophic cardiomyopathies are the most common; restrictive, noncompaction, and mixed cardiomyopathies occur infrequently; and arrhythmogenic right ventricular cardiomyopathy is rare. Pediatric cardiomyopathies can result from coronary artery abnormalities, tachyarrhythmias, exposure to infection or toxins, or secondary to other underlying disorders. Increasingly, the importance of genetic mutations in the pathogenesis of isolated or syndromic pediatric cardiomyopathies is becoming apparent...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28912184/inflammatory-cardiomyopathic-syndromes
#3
REVIEW
Barry H Trachtenberg, Joshua M Hare
Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast, inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of the heart (or myocarditis) is the proximate cause of myocardial dysfunction, causing injury that can range from a fully recoverable syndrome to one that leads to chronic remodeling and dilated cardiomyopathy. The most common cause of inflammatory cardiomyopathies in developed countries is lymphocytic myocarditis most commonly caused by a viral pathogenesis...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28904845/biomarker-for-the-prediction-of-major-adverse-cardiac-events-in-patients-with-non-st-segment-elevation-myocardial-infarction
#4
REVIEW
Ho Sun Shon, Jang-Whan Bae, Kyoung Ok Kim, Eun Jong Cha, Kyung Ah Kim
N-terminal pro-brain natriuretic peptide (NT-proBNP) is a well-known biomarker for the diagnosis and prognosis of heart failure, and is directly associated with myocardial dysfunction. We evaluated the prognostic value of NT-proBNP for major adverse cardiac events (MACEs) among patients with non-ST-segment elevation myocardial infarction (NSTEMI) from the Korea Acute Myocardial Infarction Registry during their mid-term follow-up period. In this paper, we analyzed NT-proBNP according to various MACE and level of NT-proBNP...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28884343/prognostic-impact-of-isolated-right-ventricular-dysfunction-in-sepsis-and-septic-shock-an-8-year-historical-cohort-study
#5
Saraschandra Vallabhajosyula, Mukesh Kumar, Govind Pandompatam, Ankit Sakhuja, Rahul Kashyap, Kianoush Kashani, Ognjen Gajic, Jeffrey B Geske, Jacob C Jentzer
BACKGROUND: Echocardiographic myocardial dysfunction is reported commonly in sepsis and septic shock, but there are limited data on sepsis-related right ventricular dysfunction. This study sought to evaluate the association of right ventricular dysfunction with clinical outcomes in patients with severe sepsis and septic shock. METHODS: Historical cohort study of adult patients admitted to all intensive care units at the Mayo Clinic from January 1, 2007 through December 31, 2014 for severe sepsis and septic shock, who had an echocardiogram performed within 72 h of admission...
September 7, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28875298/2d-longitudinal-lv-speckle-tracking-strain-pattern-in-breast-cancer-survivors-sports-activity-vs-exercise-as-prescription-model
#6
Giorgio Galanti, Gianni Pedrizzetti, Stefano Pedri, Laura Stefani
Prevention strategies are important to optimize and to manage heart care in breast cancer survivors. Regular physical activity at moderate intensity is normally proposed to maintain myocardial performance; however, no data is available about the different impact of different levels of physical exercise. 2D speckle tracking echocardiography (2DSTE) is an accepted method for early detection of myocardial dysfunction. The study aims to monitor the cardiac performances in breast cancer survivors by 2DSTE analysis to manage sports activity vs physical activity...
September 5, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28873333/role-of-echocardiography-in-reducing-shock-reversal-time-in-pediatric-septic-shock-a-randomized-controlled-trial
#7
Ahmed A El-Nawawy, Aly M Abdelmohsen, Hadir M Hassouna
OBJECTIVE: To evaluate the role of echocardiography in reducing shock reversal time in pediatric septic shock. METHODS: A prospective study conducted in the pediatric intensive care unit (PICU) of a tertiary care teaching hospital from September 2013 to May 2016. Ninety septic shock patients were randomized in a 1:1 ratio for comparing the serial echocardiography-guided therapy in the study group with the standard therapy in the control group regarding clinical course, timely treatment, and outcomes...
September 2, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28852440/the-cardioprotective-effect-of-vanillic-acid-on-hemodynamic-parameters-malondialdehyde-and-infarct-size-in-ischemia-reperfusion-isolated-rat-heart-exposed-to-pm10
#8
Esmat Radmanesh, Mahin Dianat, Mohammad Badavi, Gholamreza Goudarzi, Seyyed Ali Mard
OBJECTIVES: Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS AND METHODS: Eighty male Wistar rats (250-300 g) were divided into 8 groups (n=10): Control, Sham, VAc, VA, PMa (0.5 mg/kg PM, intratracheal instillation), PMb (2...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28845215/ppar-%C3%AE-activation-prevents-septic-cardiac-dysfunction-via-inhibition-of-apoptosis-and-necroptosis
#9
Shiyan Peng, Junmei Xu, Wei Ruan, Suobei Li, Feng Xiao
Sepsis-induced cardiac dysfunction remains one of the major causes of death in intensive care units. Overwhelmed inflammatory response and unrestrained cell death play critical roles in sepsis-induced cardiac dysfunction. Peroxisome proliferator-activated receptor- (PPAR-) γ has been proven to be cardioprotective in sepsis. However, the mechanism of PPAR-γ-mediated cardioprotection and its relationship with inflammation and cell death are unclear. We hypothesized that activation of PPAR-γ by reducing cardiac inflammation, myocardial apoptosis, and necroptosis may prevent myocardial dysfunction in sepsis...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28844956/interleukin-6-deficiency-facilitates-myocardial-dysfunction-during-high-fat-diet-induced-obesity-by-promoting-lipotoxicity-and-inflammation
#10
Fan Chen, Dandan Chen, Xinmei Zhao, Shuai Yang, Zhe Li, Daniel Sanchis, Liang Jin, Xizhe Qiang, Kaiye Wang, Yitao Xu, Yubin Zhang, Junmei Ye
Objective Obesity is associated with metabolic disorder and chronic inflammation that plays a crucial role in cardiovascular diseases. IL-6 is involved in regulating obesity-related lipid metabolism and inflammation. In this study, we sought to determine the role of IL-6 in high-fat diet (HFD)-induced cardiomyopathy and explore the signaling pathway. METHODS: Female, 5-week-old IL-6 knockout (KO) and littermate mice were fed a normal diet (ND, 10% fat) or HFD (45% fat) for 14 weeks. At the end of treatment, cardiac function was assessed by echocardiography...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28843067/elevated-modified-shock-index-in-early-sepsis-is-associated-with-myocardial-dysfunction-and-mortality
#11
Namita Jayaprakash, Ognjen Gajic, Ryan D Frank, Nathan Smischney
PURPOSE: The aim of this study was to explore the association of an elevated modified shock index (MSI) in sepsis and myocardial dysfunction. METHODS: This single center exploratory retrospective cohort study was conducted at Mayo Clinic from 2011 to 2014. It includes adults admitted to the medical intensive care unit with severe sepsis or septic shock. The time MSI>1.3, area under the curve, in the first 6h was assessed using logistic regression for primary outcomes of myocardial dysfunction and depression and secondary outcomes including mortality and SOFA score...
August 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28838933/epigenome-wide-association-study-identifies-cardiac-gene-patterning-and-a-novel-class-of-biomarkers-for-heart-failure
#12
Benjamin Meder, Jan Haas, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Karen Frese, Alan Lai, Rouven Nietsch, Christina Scheiner, Stefan Mester, Diana Martins Bordalo, Ali Amr, Carsten Dietrich, Dietmar Pils, Dominik Siede, Hauke Hund, Andrea S Bauer, Daniel B Holzer, Arjang Ruhparwar, Matthias Mueller-Hennessen, Dieter Weichenhan, Christoph Plass, Tanja M Weis, Johannes Backs, Maximilian L Wuerstle, Andreas Keller, Hugo A Katus, Andreas E Posch
Background -Biochemical DNA modification resembles a crucial regulatory layer between genetic information, environmental factors and the transcriptome. To identify epigenetic susceptibility regions and novel biomarkers linked to myocardial dysfunction and heart failure, we performed the first multi-omics study in myocardial tissue and blood of patients with Dilated Cardiomyopathy (DCM) and controls. Methods -Infinium HumanMethylation450 was used for high-density epigenome-wide mapping of DNA methylation in left ventricular biopsies and whole peripheral blood of living probands...
August 24, 2017: Circulation
https://www.readbyqxmd.com/read/28826719/advanced-glycation-end-products-receptor-rage-controls-myocardial-dysfunction-and-oxidative-stress-in-high-fat-fed-mice-by-sustaining-mitochondrial-dynamics-and-autophagy-lysosome-pathway
#13
Yichi Yu, Lei Wang, Florian Delguste, Arthur Durand, Axel Guilbaud, Clementine Rousselin, Ann Marie Schmidt, Frédéric Tessier, Eric Boulanger, Remi Neviere
Oxidative stress and mitochondrial dysfunction are recognized as major contributors of cardiovascular damage in diabetes and high fat diet (HFD) fed mice. Blockade of receptor for advanced glycation end products (RAGE) attenuates vascular oxidative stress and development of atherosclerosis. We tested whether HFD-induced myocardial dysfunction would be reversed in RAGE deficiency mice, in association with changes in oxidative stress damage, mitochondrial respiration, mitochondrial fission and autophagy-lysosomal pathway...
August 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28816145/strain-imaging-detects-dose-dependent-segmental-cardiac-dysfunction-in-the-acute-phase-after-breast-irradiation
#14
Queenie Lo, Leia Hee, Vikneswary Batumalai, Christine Allman, Peter MacDonald, Denise Lonergan, Geoff P Delaney, Liza Thomas
PURPOSE: We examined the utility of echocardiographic 2-dimensional speckle tracking strain imaging (SI) for the evaluation of segmental myocardial dysfunction before and after radiation therapy (RT) and the relationship to dose exposure. METHODS AND MATERIALS: We prospectively recruited 40 women with left-sided breast cancer, undergoing only adjuvant RT to the left chest. Comparisons of traditional echocardiographic parameters and SI parameters at baseline and 6 weeks after RT were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807827/the-endotoxemia-cardiac-dysfunction-is-attenuated-by-ampk-mtor-signaling-pathway-regulating-autophagy
#15
Jie Zhang, Peng Zhao, Nanhu Quan, Lin Wang, Xu Chen, Courtney Cates, Thomas Rousselle, Ji Li
AMP-activated protein kinase (AMPK), an enzyme that plays a role in cellular energy homeostasis, modulates myocardial signaling in the heart. Myocardial dysfunction is a common complication of sepsis. Autophagy is involved in the aging related cardiac dysfunction. However, the role of AMPK in sepsis-induced cardiotoxicity has yet to be clarified, especially in aging. In this study, we explored the role of AMPK in lipopolysaccharide (LPS)-induced myocardial dysfunction and elucidated the potential mechanisms of AMPK/mTOR pathway regulating autophagy in young and aged mice...
October 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28804906/efficacy-of-a-mephentermine-based-product-as-a-vasopressor-and-a-cardiac-performance-enhancer-when-given-intramuscularly-to-cattle
#16
D N Q Cunha, C L Del Rio, B L Youngblood, E L Ferris, G E Geist, Y Ueyama, L C Franz, S Mathur, R L Hamlin
The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY(®) INJETÁVEL (POT), a mephentermine-based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized-complete-block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume-matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six-day washout period, cattle received the opposite compound...
August 14, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28799999/features-of-cardiovascular-disease-in-low-income-and-middle-income-countries-in-adults-and-children-living-with-hiv
#17
Andrew W McCrary, Chidozie U Nduka, Saverio Stranges, Gerald S Bloomfield
PURPOSE OF REVIEW: The current article addresses crucial issues in identifying risk of cardiovascular disease (CVD) in people living with HIV in low-income and middle-income countries (LMICs). These issues are in need of urgent attention to advance our knowledge and inform actions to mitigate CVD in this population. We address CVDs in adults living with HIV as well as the unique aspects pertaining to children living with HIV (CLHIV), a group sorely under-represented in this field. RECENT FINDINGS: CVDs affecting adults such as hypertension, dyslipidemia, coronary artery disease, and heart failure, in addition to myocardial dysfunction, vascular diseases, and autoimmune phenomena are also being reported in CLHIV...
August 10, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28795671/-two-dimensional-speckle-tracking-imaging-in-assessing-the-left-ventricular-systolic-function-and-its-dynamic-changes-of-patients-with-septic-shock
#18
Fei Yang, Yong Chen, Ruiqiang Zheng, Yong Ma, Haidi Yu, Wenjuan Zhang, Yang Zhang
OBJECTIVE: To evaluate early and dynamic changes of the left ventricular systolic function of patients with septic shock by two-dimensional speckle tracking imaging (2D-STI), and to provide guidance for treatment and prognosis. METHODS: Fifty-eight septic shock patients admitted to intensive care unit (ICU) of Subei People's Hospital from January 2016 to April 2017 were enrolled. The septic shock patients were given early fluid resuscitation. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), early diastolic mitral flow velocity/early diastolic mitral annular peak velocity (E/Em) were obtained by conventional echocardiography, and the left ventricular global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) were obtained by 2D-STI before fluid resuscitation and 1, 3, 7, 14 days after fluid resuscitation...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28795664/-roles-of-myd88-and-trif-in-cardiac-dysfunction-during-sepsis
#19
Yun Zhu, Ming Zhang, Minzhi Ouyang, Dan Zhou, Ling Li
OBJECTIVE: To investigate the roles of myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing interferon-β (TRIF) in sepsis-induced myocardial dysfunction, and to analyze whether strain rate (SR) can be early sensitive evaluation for septic heart failure. METHODS: Sixty-four healthy male C57BL/6 mice were divided into four groups by random number table (n = 16 in each group): sham group, cecum ligation and puncture (CLP)-induced sepsis model group, anti-MyD88 group and anti-TRIF group...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28793823/role-of-atp-sensitive-potassium-channels-in-remote-ischemic-preconditioning-induced-tissue-protection
#20
Sapna Aggarwal, Puneet Kaur Randhawa, Nirmal Singh, Amteshwar Singh Jaggi
Remote ischemic preconditioning (RIPC) is an innovative treatment strategy that alleviates ischemia-reperfusion injury, whereby short episodes of regional ischemia and reperfusion delivered to remote organs including hind limb, kidney and intestine, and so on provide protection to the heart. The RIPC is known to reduce infarct size, serum levels of cardiac enzymes, and myocardial dysfunction in various animal species as well as in patients. There have been a large number of studies suggesting that the ATP-sensitive potassium channels (KATP channel) play a significant role as a mediator or end effector in RIPC...
September 2017: Journal of Cardiovascular Pharmacology and Therapeutics
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