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https://www.readbyqxmd.com/read/28339702/subclinical-chronic-left-ventricular-systolic-dysfunction-resulting-from-phosphine-poisoning
#1
E Szymczyk, M Wiszniewska, J Walusiak-Skorupa, J D Kasprzak, P Lipiec
We present a case of a 32-year-old male crew member of a cargo ship, accidentally exposed to phosphine, a fumigating substance. He and other crew members developed increasing fatigue and digestive disorders 24 h later; two died from acute pulmonary oedema. The patient was admitted to hospital, where bilateral pneumonia, acute nephritis, hepatopathy, electrolyte imbalance and leucopenia were diagnosed. He was discharged from hospital 3 weeks later. He was examined 4 months later for possible chronic consequences of acute phosphine poisoning, which included echocardiography showing normal heart size and cardiac function...
February 21, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28338005/the-association-between-diffuse-myocardial-fibrosis-on-cardiac-magnetic-resonance-t1-mapping-and-myocardial-dysfunction-in-diabetic-rabbits
#2
Mu Zeng, Yingyan Qiao, Zhaoying Wen, Jun Liu, Enhua Xiao, Changlian Tan, Yibin Xie, Jing An, Zishu Zhang, Zhanming Fan, Debiao Li
The objective of this study was to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfunction. Thirty-six New Zealand white rabbits were classified into two groups: a control group (n = 18) and an alloxan-induced diabetes mellitus (DM) group (n = 18). For all rabbits, conventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T1 mapping were performed; all of the rabbits were then sacrificed for Masson's staining. The extracellular volume (ECV) was calculated from pre- and post-contrast T1 values and compared with myocardial function measured by echocardiography using Pearson's correlation...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333102/biological-effect-of-licochalcone-c-on-the-regulation-of-pi3k-akt-enos-and-nf-%C3%AE%C2%BAb-inos-no-signaling-pathways-in-h9c2-cells-in-response-to-lps-stimulation
#3
Sara Franceschelli, Mirko Pesce, Alessio Ferrone, Daniela Maria Pia Gatta, Antonia Patruno, Maria Anna De Lutiis, José Luis Quiles, Alfredo Grilli, Mario Felaco, Lorenza Speranza
Polyphenols compounds are a group molecules present in many plants. They have antioxidant properties and can also be helpful in the management of sepsis. Licochalcone C (LicoC), a constituent of Glycyrrhiza glabra, has various biological and pharmacological properties. In saying this, the effect of LicoC on the inflammatory response that characterizes septic myocardial dysfunction is poorly understood. The aim of this study was to determine whether LicoC exhibits anti-inflammatory properties on H9c2 cells that are stimulated with lipopolysaccharide...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332215/effects-of-increased-left-ventricular-wall-thickness-on-the-myocardium-in-severe-aortic-stenosis-with-normal-left-ventricular-ejection-fraction-two-and-three-dimensional-multilayer-speckle-tracking-echocardiography
#4
Eun Jeong Cho, Sung-Ji Park, Eun Kyoung Kim, Ga Yeon Lee, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park
BACKGROUND: The aim of this study was to determine the capability of real time three-dimensional echocardiography (RT3DE) and two-dimensional (2D) multilayer speckle tracking echocardiography (MSTE) for evaluation of early myocardial dysfunction triggered by increased left ventricular (LV) wall thickness in severe aortic stenosis (AS) with normal LV ejection fraction (EF≥55%). METHODS: Conventional, RT3D STE and 2D MSTE were performed in 45 patients (mean 68.9±9...
March 23, 2017: Echocardiography
https://www.readbyqxmd.com/read/28322888/review-manuscript-pneumolysin-as-a-potential-therapeutic-target-in-severe-pneumococcal-disease
#5
REVIEW
Ronald Anderson, Charles Feldman
Acute pulmonary and cardiac injury remain significant causes of morbidity and mortality in those afflicted with severe pneumococcal disease, with the risk for early mortality often persisting several years beyond clinical recovery. Although remaining to be firmly established in the clinical setting, a considerable body of evidence, mostly derived from murine models of experimental infection, has implicated the pneumococcal, cholesterol-binding, pore-forming toxin, pneumolysin (Ply), in the pathogenesis of lung and myocardial dysfunction...
March 16, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28321497/intra-procedural-determination-of-viability-by-myocardial-deformation-imaging-a-randomized-prospective-study-in-the-cardiac-catheter-laboratory
#6
Alexander Schuh, Vadim Karayusuf, Ertunc Altiok, Sandra Hamada, Jörg Schröder, Andras Keszei, Malte Kelm, Matias de la Fuente, Michael Frick, Klaus Radermacher, Nikolaus Marx, Michael Becker
BACKGROUND: The benefit of revascularization for functional recovery depends on the presence of viable myocardial tissue. OBJECTIVE: Myocardial deformation imaging allows determination of myocardial viability. METHODS: In a first approach, we assessed the optimal cutoff value to determine preserved viability by layer-specific echocardiographic myocardial deformation imaging at rest and low-dose dobutamine (DSE) echocardiography: regional endocardial circumferential strain (eCS) <-19% at rest was as accurate as eCS at DSE...
March 20, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28317158/left-ventricular-hypertrophy-or-storage-disease-the-incremental-value-of-speckle-tracking-strain-bull-s-eye
#7
REVIEW
Antonello D'Andrea, Juri Radmilovic, Piercarlo Ballo, Donato Mele, Eustachio Agricola, Matteo Cameli, Andrea Rossi, Roberta Esposito, Giuseppina Novo, Sergio Mondillo, Roberta Montisci, Sabina Gallina, Eduardo Bossone, Maurizio Galderisi
Left ventricular hypertrophy (LVH) develops in response to a variety of physical, genetic, and biochemical stimuli and represents the early stage of ventricular remodeling. In patients with LVH, subclinical left ventricular (LV) dysfunction despite normal ejection fraction (EF) may be present before the onset of symptoms, which portends a dismal prognosis. Strain measurement with two-dimensional speckle tracking echocardiography (STE) represents a highly reproducible and accurate alternative to LVEF determination...
March 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28314504/low-ejection-fraction-in-donor-hearts-is-not-directly-associated-with-increased-recipient-mortality
#8
Carol W Chen, Michael H Sprys, Ann C Gaffey, Jennifer J Chung, Kenneth B Margulies, Michael A Acker, Pavan Atluri
BACKGROUND: Reduced left ventricular ejection fraction (EF) in the donor heart is often a contraindication for transplant. However, small studies have validated the use of hearts with evidence of myocardial dysfunction to boost the number of organs available for transplant. We hypothesize that donor hearts with reduced EF undergo myocardial recovery after transplant and result in equivalent recipient survival compared with grafts with normal function. METHODS: We examined post-operative outcomes of heart recipients in the database of the United Network for Organ Sharing...
February 4, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28291104/new-approaches-to-modifying-inotropy-in-sepsis-induced-myocardial-dysfunction
#9
Keith R Walley
No abstract text is available yet for this article.
April 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28285861/cardioprotective-effect-of-nicorandil-against-myocardial-injury-following-cardiac-arrest-in-swine
#10
Li-Ning Liang, Xia Zhong, Yi Zhou, Zhi-Qiang Hou, Hao-Ran Hu, Fang-Fang Zhu, Ji-Bin Chen, Xian-Fei Ji, De-Ya Shang
INTRODUCTION: Nicorandil, a vasodilatory drug used to treat angina, was reported to protect against myocardial ischemia-reperfusion injury in various animal models. However, its cardioprotective action following cardiac arrest is unknown. We examined the cardioprotective effects of nicorandil in a porcine model of cardiac arrest and resuscitation. METHODS: Ventricular fibrillation was induced electrically for 4min in anesthetized domestic swine, followed by cardiopulmonary resuscitation...
March 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28276515/mri-assessment-of-cardiomyopathy-induced-by-%C3%AE-1-adrenoreceptor-autoantibodies-and-protection-through-%C3%AE-3-adrenoreceptor-overexpression
#11
Laetitia Vanhoutte, Céline Guilbaud, Ruben Martherus, Caroline Bouzin, Bernard Gallez, Chantal Dessy, Jean-Luc Balligand, Stéphane Moniotte, Olivier Feron
The cardiopathogenic role of autoantibodies (aabs) directed against β1-adrenoreceptors (β1-AR) is well established. In mouse models, they cause progressive dilated cardiomyopathy (DCM) whose characterization with echocardiography requires prolonged protocols with numerous animals, complicating the evaluation of new treatments. Here, we report on the characterization of β1-aabs-induced DCM in mice using 11.7T MRI. C57BL/6J mice (n = 10 per group) were immunized against the β1-AR and left ventricular (LV) systolic function was assessed at 10, 18 and 27 weeks...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262493/assessment-of-cardiovascular-impairment-in-obese-patients-limitations-and-troubleshooting-of-available-imaging-tools
#12
V Gaudieri, C Nappi, W Acampa, R Assante, E Zampella, M Magliulo, M Petretta, A Cuocolo
The prevalence and severity of obesity have increased over recent decades, reaching worldwide epidemics. Obesity is associated to coronary artery disease and other risk factors, including hypertension, heart failure and atrial fibrillation, which are all increased in the setting of obesity. Several noninvasive cardiac imaging modalities, such as echocardiography, cardiac computed tomography, magnetic resonance and cardiac gated single-photon emission computed tomography, are available in assessing coronary artery disease and myocardial dysfunction...
March 2, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28258912/risk-stratification-and-pattern-of-cardiotoxicity-in-pediatric-ewing-sarcoma
#13
Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat
INTRODUCTION: Anthracycline chemotherapy contributes to improved outcomes in Ewing sarcoma; however, the most feared complication is cardiotoxicity. Echocardiograms were routinely used to monitor cardiac function after anthracycline treatment. Nevertheless, indices chosen to assess cardiac toxicity vary significantly among different centers, and no uniform protocol has been accepted as ideal. METHODS: This retrospective study included children with Ewing sarcoma treated at Children's Cancer Hospital Egypt over 4years...
February 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28256321/trimetazidine-in-conditions-other-than-coronary-disease-old-drug-new-tricks
#14
REVIEW
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen
Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28241239/myocardial-dysfunction-in-tetralogy-of-fallot-and-its-association-with-outcome
#15
Craig S Broberg
No abstract text is available yet for this article.
February 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28219811/stress-echocardiography-in-patients-who-experienced-mechanical-ventilation-weaning-failure
#16
Manuel Ruiz-Bailén, Jesús Cobo-Molinos, Ana Castillo-Rivera, María Dolores Pola-Gallego-de-Guzmán, Antonio Cárdenas-Cruz, Antonio Martínez-Amat, María Sevilla-Martínez, Clara Hernández-Caballero
INTRODUCTION: Critically ill patients may suffer varying degrees of temporary myocardial dysfunction during respiratory weaning that could play an important role in weaning failure. OBJECTIVES: In this study, we tried to assess the existence of temporary diastolic dysfunction during respiratory weaning. METHODS: Inclusion period is from 2006 to 2015. In this study, we included 181 ventilated patients with cardiogenic shock that were being weaned from mechanical ventilation...
January 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28204860/left-ventricular-systolic-dysfunction-during-septic-shock-the-role-of-loading-conditions
#17
Florence Boissier, Keyvan Razazi, Aurélien Seemann, Alexandre Bedet, Arnaud W Thille, Nicolas de Prost, Pascal Lim, Christian Brun-Buisson, Armand Mekontso Dessap
PURPOSE: The clinical significance of septic myocardial dysfunction is controversial, a fact that may be explained by the influence of loading conditions. Many indices may be useful to characterize cardiac function during septic shock, but their feasibility and physiological coherence in the clinical setting are unknown. METHODS: Hemodynamic and echocardiographic data with tissue Doppler and speckle tracking were prospectively recorded on the first 3 days of human septic shock...
February 15, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28191665/apical-left-ventricular-myocardial-dysfunction-is-an-early-feature-of-cardiac-involvement-in-myotonic-dystrophy-type-1
#18
Rodrigue Garcia, Quentin Labarre, Bruno Degand, Pierre Ingrand, François Le Gal, Benjamin Bonnet, Anne Delaubier, Claire Guillou, Barnabas Gellen, Damien Coisne, Claire Bouleti, Luc Christiaens
INTRODUCTION: Left ventricular (LV) dysfunction is a major prognostic determinant in myotonic dystrophy type 1 (DM1). Therefore, markers of early-stage LV impairment may be useful. The aim of this study was to evaluate 2D echocardiographic LV strain in a cohort of DM1 patients with preserved left ventricular ejection fraction (LVEF) and to compare the results with matched controls. METHODS: This prospective single-center study included 33 consecutive DM1 patients between February 2014 and February 2015...
February 2017: Echocardiography
https://www.readbyqxmd.com/read/28184975/alkaline-phosphatase-a-biomarker-of-cardiac-function-in-pediatric-patients
#19
Elizabeth S Makil, Xinyu Tang, Elizabeth A Frazier, R Thomas Collins
Myocardial dysfunction and heart failure are common in pediatric patients with congenital and acquired heart disease. Alkaline phosphatase (AP) has been suggested as a biomarker for myocardial dysfunction after Fontan operation. We hypothesized that pediatric patients with myocardial dysfunction requiring orthotopic heart transplant (OHT) have diminished AP compared to normal. A retrospective review was performed in all patients who underwent OHT at Arkansas Children's Hospital between January 2007 and October 2012...
February 9, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28180202/applicability-and-technical-aspects-of-two-dimensional-ultrasonography-for-assessment-of-fetal-heart-function
#20
REVIEW
Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Luciano Marcondes Nardozza, Alex Sandro Souza, Edward Araujo Júnior
In recent years, fetal echocardiography has been used for the screening and diagnosis of anatomical heart defects and for the detailed study of fetal cardiac function. This method is characterized by its easy implementation and good reproducibility, allowing the diagnosis of myocardial dysfunction even in its subclinical phase. The functional assessment of the fetal heart should be routinely performed in fetuses with congenital heart disease and those without anatomical malformation. Several extra-cardiac conditions may alter fetal cardiac function, by increased placental resistance, volume overload or hyperdynamic circulation, compression, or maternal systemic disease with involvement of the fetal myocardium...
January 31, 2017: Medical Ultrasonography
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