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R Tafer, M Sleiman, A Boulkamh, C Richard
The photolysis of aqueous 5-chlorosalicylic acid (ClSA) and dihydroxybenzoic acid (DHBA), its main photoproduct, was studied to determine the extent of degradation caused by simulated solar light. Photoproducts identification was achieved using high resolution LC-MS and GC-MS. About 40 photoproducts from C19 to C1 were characterized, including a dihydroxycyclopentadienic acid, a ring contraction photoproduct, and numerous carbonyls and carboxylic acid derivatives that were detected thanks to derivatization...
October 15, 2016: Water Research
Alexandra Kodadová, Zuzana Vitková, Jarmila Oremusová, Petra Herdová, Anton Ťažký, Peter Mikuš
This work was aimed at a progressive formulation of drugs into chitosan hydrogels. It was taken into consideration that a therapeutic effect of the drugs could be enhanced by a combination of natural compounds with chemical (synthetic) drugs. In this work, sage essential oil (SEO) bicyclic monoterpenes with antiflogistic, antiseptic, and antimycotic properties were combined with terbinafine (TB) having a strong antimycotic activity. Detail optimization of the hydrogel-drugs composition (SEO monoterpenes, TB, chitosan, and polysorbate 80 concentrations), based on permeation experiment and UV absorption/GC-MS analysis of permeated species (eucalyptol, camphor, borneol, thujone, TB) in dialysates, was made...
October 22, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Xiaxia Meng, Dengwu Li, Dan Zhou, Dongmei Wang, Qiaoxiao Liu, Sufang Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus rigida is used as Tibetan and Mongolian medicine in China for the treatment of rheumatoid arthritis, nephritis, brucellosis and other various inflammatory diseases. AIM OF THE STUDY: To evaluate antibacterial potential of essential oils from J. rigida leaves against Klebsiella pneumoniae and to examine its possible related mechanisms. The study was undertaken in order to scientifically validate the traditional use of J. rigida...
October 18, 2016: Journal of Ethnopharmacology
Héloïse Coté, Marie-Anne Boucher, André Pichette, Benoit Roger, Jean Legault
ETHNOPHARMACOLOGICAL RELEVANCE: Oleoresin of Abies balsamea (L.) Mill. was used by Aboriginal people of the boreal forest of Canada and French Canadians to treat various infections, suggesting that oleoresin has antibacterial properties. AIM OF THE STUDY: In this study, the antibacterial activity of whole oleoresin from A. balsamea was investigated against E. coli, S. aureus and two methicillin-resistant S. aureus (MRSA) strains using a new sensitive assay developed to evaluate hydrophobic matrix and compounds...
October 18, 2016: Journal of Ethnopharmacology
Ali Reza Fardin-Kia
Non-conjugated geometric/positional isomers of linoleic acid (c9,c12-18:2) are often present in processed foods and oils. The following work presents a simple addition/elimination reaction for preparation of non-conjugated 18:2 fatty acid isomers. A mixture containing positional and geometric isomers of C18:2 fatty acids was produced by addition of hydrobromic acid to the fatty acid double bonds, followed by its elimination with a strong sterically hindered base. Pure 8,12-, 8,13-, 9,12-, and 9,13-18:2 fatty acid methyl esters were isolated from the synthetic mixture by a combination of sub-ambient RP-HPLC and Ag(+)-HPLC...
October 18, 2016: Chemistry and Physics of Lipids
Ji Ye Lee, Na Hyun Park, Wonwoong Lee, Eun Hye Kim, Young Ho Jin, Eun Kyung Seo, Jongki Hong
A comprehensive profiling method was established for the determination of various chemicals in Pinellia (P.) ternata and pedatisecta species. The profiling method comprises a fast ultrasonic extraction with various solvents, followed by GC-MS and LC-APCI-MS analysis. A total of 73 polar components as trimethylsilyl (TMS) derivatives were detected in methanol extract by GC-MS. The main components of the P. species were profiled as several kinds of fatty acids, amino acids, nucleic acids, carbohydrates, and phenolic compounds...
October 13, 2016: Journal of Chromatography. A
Ilaria Degano, Jacopo La Nasa, Elisa Ghelardi, Francesca Modugno, Maria Perla Colombini
Lipid binders have traditionally been determined in paintings by using gas chromatography/mass spectrometry (GC/MS) to identify the characteristic profiles and ratios of fatty acids . However, the presence of mixtures in contemporary and modern oil paints makes the GC/MS determination of fatty acids insufficient to fully characterize the lipid binding media. In this study we prove that triacylglycerol (TAG) profiling by high-performance liquid chromatography with high-resolution tandem mass spectrometry, using ESI in positive and negative ionization modes is highly effective...
December 1, 2016: Talanta
Gabrieli Bernardi, Magali Kemmerich, Lucila C Ribeiro, Martha B Adaime, Renato Zanella, Osmar D Prestes
An effective method has been developed and validated for the determination of residues of 55 pesticides in tobacco. The proposed sample preparation method is based on acetonitrile extraction, low-temperature precipitation (LTP) and dispersive solid phase extraction (d-SPE) clean-up. Gas chromatography and ultra-high performance liquid chromatography analysis, both coupled to tandem mass spectrometry (GC-MS/MS and UHPLC-MS/MS), were used for determination. LTP is easy to perform and was crucial to obtain a clean extract...
December 1, 2016: Talanta
Michael S Gross, Hernando J Olivos, Deena M Butryn, James R Olson, Diana S Aga
Hydroxylated polybrominated diphenyl ethers (OH-BDEs), which have anthropogenic and natural origins, have exhibited neurotoxic and endocrine disrupting effects in humans and wildlife. Therefore, there is an increased interest in the analysis of these compounds in biological matrices in order to assess their potential toxicological risks. Analysis of OH-BDEs is conventionally completed using liquid chromatography/mass spectrometry (LC/MS), or by gas chromatography/mass spectrometry (GC/MS) after derivatization...
December 1, 2016: Talanta
Rui Yang, Yuxin Liu, Xiangyang Yan, Shaomin Liu
A rapid, sensitive and accurate method for the simultaneous extraction and determination of five types of trace phthalate esters (PAEs) in environmental water and beverage samples using magnetic molecularly imprinted solid-phase extraction (MMIP-SPE) coupled with gas chromatography-mass spectrometry (GC-MS) was developed. A novel type of molecularly imprinted polymers on the surface of yolk-shell magnetic mesoporous carbon (Fe3O4@void@C-MIPs) was used as an efficient adsorbent for selective adsorption of phthalate esters based on magnetic solid-phase extraction (MSPE)...
December 1, 2016: Talanta
Nadia G Kandile, Mansoura I Mohamed, Hind M Ismaeel
New compounds based on oxindole moiety were synthesized via the reaction of 5-substitued isatins 1a-e with different nucleophiles such as benzidine, 3,3'-dimethoxybenzidine 2a,b and 2,6-diaminopyridine 3 to afford three different classes of bis-Schiff bases 4a-e, 5a-e and 6a-e, respectively. The structures of the new compounds were elucidated on the basis of their FTIR, (1)H NMR, (13)C NMR, GC/MS spectral data and elemental analysis. The in vitro antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four bacterial and two fungal pathogens and anticancer activities against HELA cervix...
October 21, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
Katayoun Mahdavi Ara, Farhad Raofie
Essential oils and volatile components of pomegranate (Punica granatum L.) peel of the Malas variety from Meybod, Iran, were extracted using supercritical fluid extraction (SFE) and hydro-distillation methods. The experimental parameters of SFE that is pressure, temperature, extraction time, and modifier (methanol) volume were optimized using a central composite design after a (2(4-1)) fractional factorial design. Detailed chemical composition of the essential oils and volatile components obtained by hydro-distillation and optimum condition of the supercritical CO2 extraction were analyzed by GC-MS, and seventy-three and forty-six compounds were identified according to their retention indices and mass spectra, respectively...
July 2016: Journal of Food Science and Technology
John J Guardiola, Juliane I Beier, K Cameron Falkner, Benjamin Wheeler, Craig James McClain, Matt Cave
BACKGROUND: Occupational vinyl chloride (VC) exposures have been associated with toxicant-associated steatohepatitis and liver cancer. Metabolomics has been used to clarify mode of action in drug-induced liver injury but has not been performed following VC exposures. METHODS: Plasma samples from 17 highly exposed VC workers without liver cancer and 27 unexposed healthy volunteers were obtained for metabolite extraction and GC/MS and LC/MS(2) analysis. Following ion identification/quantification, Ingenuity pathway analysis was performed...
October 17, 2016: Toxicology and Applied Pharmacology
Lêniféré Chantal Soro, Sylvie Munier, Yves Pelissier, Lidwine Grosmaire, Rickey Yada, David Kitts, Anin Louise Ocho-Anin Atchibri, Caroline Guzman, Frédéric Boudard, Chantal Menut, Jean Charles Robinson, Patrick Poucheret
ETHNOPHARMACOLOGICAL RELEVANCE: Lippia multiflora is a plant with nutritional and pharmaco-therapeutic properties that is native to central and occidental Africa. The potential effects of plants on health are associated with their chemical composition. Therefore, the present study aimed to identify chemical variations in essential oils of Lippia multiflora as a function of geographic origin and time of annual harvest to determine optimal chemical profiles for ethno-pharmacotherapeutic applications...
October 17, 2016: Journal of Ethnopharmacology
Dong Bok Jeon, Young Shin Hong, Ga Hyun Lee, Yu Min Park, Cheong Mi Lee, Eun Yeong Nho, Ji Yeon Choi, Nargis Jamila, Naeem Khan, Kyong Su Kim
Tea contains characteristic volatile organic compounds, polyphenols, caffeine and catechins, and is therefore among the most widely consumed beverages all over the world. In this study, fresh Jukro tea leaves collected from Damyang-gun (Jeollanam-do) at 40, 60 and 90day growth stages, were semi-fermented. The volatile organic compounds (VOCs) were extracted by simultaneous distillation-solvent extraction (SDE) and analyzed by gas chromatography/mass spectrometry (GC/MS). Catechins, caffeine and theanine were analyzed by high performance liquid chromatography (HPLC)...
March 15, 2017: Food Chemistry
Wenjing Chu, Haiyan Gao, Shifeng Cao, Xiangjun Fang, Hangjun Chen, Shangyue Xiao
The chemical composition and morphology of cuticular wax in mature fruit of nine blueberry cultivars were investigated using gas chromatography-mass spectrometry (GC-MS) and scanning electron microscope (SEM). Triterpenoids and β-diketones were the most prominent compounds, accounting for on average 64.2% and 16.4% of the total wax, respectively. Ursolic or oleanolic acid was identified as the most abundant triterpenoids differing in cultivars. Two β-diketones, hentriacontan-10,12-dione and tritriacontan-12,14-dione, were detected in cuticular wax of blueberry fruits for the first time...
March 15, 2017: Food Chemistry
Ramona Bosse Née Danz, Melanie Wirth, Annette Konstanz, Thomas Becker, Jochen Weiss, Monika Gibis
A simple, reliable and automated method was developed and optimized for qualification and quantification of aroma-relevant volatile marker compounds of North European raw ham using a headspace (HS)-Trap gas chromatography-mass spectrometry (GC-MS) and GC-flame ionization detector (FID) analysis. A total of 38 volatile compounds were detected with this HS-Trap GC-MS method amongst which the largest groups were ketones (12), alcohols (8), hydrocarbons (7), aldehydes (6) and esters (3). The HS-Trap GC-FID method was optimized for the parameters: thermostatting time and temperature, vial and desorption pressure, number of extraction cycles and salt addition...
March 15, 2017: Food Chemistry
Thais M Uekane, Luca Nicolotti, Alessandra Griglione, Humberto R Bizzo, Patrizia Rubiolo, Carlo Bicchi, Maria Helena M Rocha-Leão, Claudia M Rezende
The volatile fraction of murici, bacuri and sapodilla are here studied because of their increasing interest for consumers, abundance of production in Brazil, and the general demand for new flavors and aromas. Their volatile profiles were studied by two High Concentration Capacity Headspace techniques (HCC-HS), Headspace Solid Phase Microextraction (HS-SPME) and Headspace Sorptive Extraction (HSSE), in combination with GC-MS. Murici volatile fraction mainly contains esters (38%), carboxylic acids (19%), aldehydes (11%), alcohols (14%), others (13%) and sulfur compounds; bacuri is characterized by terpenes (41%), non-terpenic alcohols (24%), esters (15%), aldehydes (6%), and others (12%); sapodilla consists of esters (33%), alcohols (27%), terpenes (18%) and others (21%)...
March 15, 2017: Food Chemistry
D Shormanov, E P Tsatsua, T F Koropova, K Astashkina, Intern Yangolenko
The objective of the present study was to elucidate the peculiarities of the determination of 2-chloro-1,4-dihydrooxybenzene in the tissues of different organs and blood. The analytical methods used in the study included TLC, GC-MS, and UF-spectrophotometry. The study has demonstrated the usefulness of using acetone as an insulating solvent for the extraction of 2-chloro-1,4-dihydrooxybenzene from the biological materials. It was shown that the compound being analyzed can be separated from the endogenous substances contained in the biological matrices on the "Silasorb C-18" columns, 30 mcm...
2016: Sudebno-meditsinskaia Ekspertiza
Ioana-Coralia Feher, Zaharie Moldovan, Ioan Oprean
In this study, analysis of variance (ANOVA), cluster analysis (CA) and principal component analysis (PCA) were employed in order to evaluate the concentration profile of organic contaminants found in three main river from central Transylvania, Romania. Samples were collected from nine sampling stations, in two different sampling campaigns (wet season and dry season). Water samples were extracted using solid-phase extraction and analyzed using gas chromatography coupled with mass spectrometry (GC/MS). Twelve organic pollutants belonging to different classes were used for further interpretations...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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