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https://www.readbyqxmd.com/read/27908782/adaptive-responses-of-neuronal-mitochondria-to-bioenergetic-challenges-roles-in-neuroplasticity-and-disease-resistance
#1
REVIEW
Sophia M Raefsky, Mark P Mattson
An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca(2+), CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance. These pathways are also activated by aerobic exercise and food deprivation, two bioenergetic challenges of fundamental importance in the evolution of the brains of all mammals, including humans...
November 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27907236/suicide-by-intentional-air-embolism
#2
Gábor Simon, Evelin Rácz, Mátyás Mayer, Veronika Heckmann, Dénes Tóth, Zsolt Kozma
Venous air embolism occurs when air enters the venous system. The main causes of venous air embolism include medical procedures, neck and head trauma, and injuries of the genitals. Self-induced suicidal (and intentional) air embolism is extremely rare. The authors report a rare case of a suicidal air embolism committed using a self-made tool composed of a plastic bottle and an infusion set, injecting nearly 2000 mL of air into the cubital vein. The toxicological analysis suggested that midazolam, together with air, was also injected into the circulation using the same bottle and infusion set...
December 1, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27906849/carotid-artery-aneurysm-a-rare-cause-of-hemotympanum
#3
Selçuk Güneş, Zahide Mine Yazici, Hakan Selçuk, Baver Masallah Şimşek, Mustafa Çelik, Fatma Tülin Kayhan
Temporal bone fractures can occur as a result of various head trauma. The most common cause of the hemotympanum is traumatic temporal bone fracture. Facial paralysis and hearing loss can be seen associated with temporal bone fracture. The development of the internal carotid artery aneurysm after temporal bone fracture is extremely rare. In this article, the authors evaluated carotid artery aneurysm that developed after temporal fracture and aneurism compressed by coagulated blood mass which showed itself as a hemotympanum...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27904755/paraplegia-caused-by-cerebral-contusions-in-the-bilateral-precentral-gyri
#4
Hideaki Matsumura, Hiroyuki Fujimori, Naoaki Sato, Akira Matsumura
BACKGROUND: Paraplegia is mainly caused by spinal cord disease and rarely occurs due to head trauma. In this report, we describe a case of paraplegia caused by cerebral contusions in the bilateral precentral gyri. CASE DESCRIPTION: A 72-year-old man was admitted to our hospital with mildly impaired consciousness and severe pure motor paralysis in both legs. He was healthy until the morning of the day, but his wife found him injured in front of his house upon returning home...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27894562/todd-s-paresis-in-acute-mild-head-trauma
#5
Alan Cowley, David Wright, Thomas Breen, Richard Lyon
We present the case of an adult male who sustained Todd's paresis after a traumatically induced seizure in a patient with an isolated facial injury. The precipitating event was head trauma from a golf club. The patient had no previous history of seizures and went on to make a complete neurologic recovery with no cerebral pathology noted. A literature review suggests that Todd's paresis after trauma is very rare as opposed to occurring in the medical or long-term brain injury settings. Although the authors acknowledge that it may occur in trauma, the awareness within the prehospital setting is sufficiently rare for this case report to be of interest to prehospital clinicians; it is important prehospital clinicians are aware of this condition...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27893181/synaesthesia-lost-and-found-two-cases-of-person-and-music-colour-synaesthesia
#6
Francesca R Farina, Kevin J Mitchell, Richard A P Roche
Synaesthesia is a developmental condition involving cross-communication between sensory modalities or substreams whereby an inducer (e.g. a sound) automatically evokes a concurrent percept in another modality (e.g. a colour). Whether this condition arises due to atypical structural connectivity (e.g., between normally unconnected cortical areas) or altered neurochemistry remains a central question. We report the exceptional cases of two synaesthetes - subjects AB and CD - both of whom experience coloured auras around individuals, as well as coloured perceptions in response to music...
November 28, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27889010/neuropsychiatric-aspects-of-concussion
#7
REVIEW
Rajiv Radhakrishnan, Amir Garakani, Lawrence S Gross, Marcia K Goin, Janet Pine, Andrew E Slaby, Calvin R Sumner, David A Baron
Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cause of psychiatric morbidity, especially when the patient has no history of loss of consciousness or direct head trauma. Almost all of the extant literature focuses on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain injury, which has resulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat its varied neuropsychiatric symptoms...
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27885942/enlarged-subarachnoid-spaces-and-intracranial-hemorrhage-in-children-with-accidental-head-trauma
#8
Amanda K Fingarson, Maura E Ryan, Suzanne G McLone, Corey Bregman, Emalee G Flaherty
OBJECTIVE Benign external hydrocephalus (BEH) is an enlargement of the subarachnoid spaces (SASs) that can be seen in young children. It is controversial whether children with BEH are predisposed to developing subdural hemorrhage (SDH) with or without trauma. This issue is clinically relevant as a finding of unexplained SDH raises concerns about child abuse and often prompts child protection and law enforcement investigations. METHODS This retrospective study included children (1-24 months of age) who underwent head CT scanning after an accidental fall of less than 6 feet...
November 25, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27882255/tip-of-an-iceberg-skull-fracture-as-an-adult-presentation-of-encephalocraniocutaneous-lipomatosis
#9
Sinead Culleton, Christen D Barras, Hamed Asadi, Seamus Looby, Paul Brennan, Hong Kuan Kok
The severity of seizures presenting to the emergency department ranges from benign to life threatening. There are also a wide number of possible etiologies. Computed tomography (CT) emergency imaging may be required at presentation to elucidate a possible cause and assess signs of intracranial trauma. This case describes a serious seizure episode in a young man while on holiday. A CT brain showed a skull fracture as a consequence of seizure-related head trauma but unexpectedly there were image findings consistent with encephalocraniocutaneous lipomatosis...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27876657/clinical-predictors-of-intracranial-injuries-in-infants-with-minor-head-trauma
#10
Hidenori Ohbuchi, Shinji Hagiwara, Kengo Hirota, Hirokazu Koseki, Yasuhiro Kuroi, Naoyuki Arai, Hidetoshi Kasuya
OBJECTIVE: Minor head trauma is common in children. Though most cases are nonsignificant, minor head trauma can lead to the deterioration of intracranial injuries, which is preventable. The aim of this study was to identify clinical predictors of intracranial injuries in infants with minor head trauma. METHODS: We retrospectively enrolled infants under 11 months with minor head trauma between 2006 and 2013. The following data were recorded: age, sex, cause of trauma, fall height, vomiting, bad temper, size and location of scalp hematoma, fracture, and intracranial injuries on CT...
November 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27872225/the-head-trauma-amnesia-cure-the-making-of-a-medical-myth
#11
Nitin K Sethi, Mary V Spiers
No abstract text is available yet for this article.
November 22, 2016: Neurology
https://www.readbyqxmd.com/read/27865726/-falls-in-less-than-one-year-old-infants-management-in-the-emergency-department
#12
Elena Rubio García, Ana Jiménez de Domingo, Rafael Marañon Pardillo, Miriam Triviño Rodríguez, Luis Alberto Frontado Haiek, Nuria Gilabert Iriondo, Francesc Ripoll Oliveras, Cristina Remón García, Gloria Estopiña Ferrer, Cristina Muñoz López
OBJECTIVES: A study was performed in order to describe injuries associated with falls in children aged <1 year who attended the emergency department. The approaches used were examined, as well as the factors associated with the greater use of these approaches, and the management of the patient. PATIENTS AND METHODS: This was a multicentre, descriptive and analytical study that included all patients aged <1 year who had experienced a fall for which they attended the emergency departments of one of 8 Spanish Hospitals belonging to the "Unintentional Paediatric Injury Working Group" of the Spanish Paediatric Society...
November 16, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27864928/classification-of-porcine-cranial-fracture-patterns-using-a-fracture-printing-interface
#13
Feng Wei, Serhat Selçuk Bucak, Jennifer M Vollner, Todd W Fenton, Anil K Jain, Roger C Haut
Distinguishing between accidental and abusive head trauma in children can be difficult, as there is a lack of baseline data for pediatric cranial fracture patterns. A porcine head model has recently been developed and utilized in a series of studies to investigate the effects of impact energy level, surface type, and constraint condition on cranial fracture patterns. In the current study, an automated pattern recognition method, or a fracture printing interface (FPI), was developed to classify cranial fracture patterns that were associated with different impact scenarios documented in previous experiments...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27862642/external-validation-of-the-pecarn-head-trauma-prediction-rules-in-japan
#14
Kentaro Ide, Satoko Uematsu, Kenichi Tetsuhara, Satoshi Yoshimura, Takahiro Kato, Tohru Kobayashi
OBJECTIVES: The Pediatric Emergency Care Applied Research Network (PECARN) head trauma prediction rules are used to assist computed tomography (CT) decision-making for children with minor head trauma. Although the PECARN rules have been validated in North America and Europe, they have not yet been validated in Asia. In Japan, there are no clinical decision rules for children with minor head trauma. The rate of head CT for children with minor head trauma in Japan is high since CT is widely accessible across the country...
November 12, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27857923/a-case-of-traumatic-unilateral-internuclear-ophthalmoplegia-clinical-significance-of-susceptibility-weighted-imaging
#15
Shin-Heon Lee, Taek-Kyun Nam, Yong-Sook Park, Jeong-Taik Kwon
A 43-year-old man was admitted for head trauma after falling backward. The patient complained of diplopia. Unilateral internuclear ophthalmoplegia (INO) was diagnosed during the neurologic examination. Initially, no specific finding was shown on T2-weighted, T1-weighted, and fluid attenuated inversion recovery brain magnetic resonance image (MRI) or brain computed tomography (CT). However, susceptibility-weighted imaging (SWI) definitively demonstrated a tiny hemorrhage at the midline of the pontomesencephalic junction...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857918/effectiveness-of-cortical-atrophy-scale-and-indirect-indices-of-brain-atrophy-to-predict-chronic-subdural-hematoma-in-older-patients
#16
Eun-Oh Jeong, Seung-Won Choi, Jeong-Wook Lim, Hyon-Jo Kwon, Seon-Hwan Kim, Hyeon-Song Koh, Jin-Young Youm, Shi-Hun Song
OBJECTIVE: To determine whether baseline cerebral atrophy can predict the rate of future chronic subdural hematoma (CSDH) after head trauma and compare indirect markers of brain atrophy with volumetric analysis of computed tomography (CT). METHODS: Single institution case-control study involving 1,476 patients who visited our hospital after head trauma from January 2009 to December 2014. Forty-one patients with delayed CSDH were identified and age, gender matched 41 patients were selected as control group...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857915/correlation-between-head-trauma-and-outcome-of-chronic-subdural-hematoma
#17
Dong Han Kim, Eun Suk Park, Min Soo Kim, Sung Ho Park, Jun Bum Park, Soon Chan Kwon, In Uk Lyo, Hong Bo Sim
OBJECTIVE: Our study examined the prognostic factors involved in the outcome of patients with chronic subdural hematoma (CSDH) who had undergone burr hole drainage procedures, and investigated the association between outcome and traumatic head injury. In addition, we explored factors related to recurrence. METHODS: This study enrolled 238 patients with CSDH who had undergone burr hole drainage. Patients with history of head injury were categorized into the head trauma group and were compared with the no head trauma group...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857912/biomarkers-of-physiological-disturbances-for-predicting-mortality-in-decompressive-craniectomy
#18
Young Ha Jeong, So Hyun Kim, Eun Hee Choi, Kum Whang
OBJECTIVE: Of many critical care regimens, the management of physiological disturbances in serum is particularly drawing an attention in conjunction with patient outcome. The aim of this study was to assess the association of serum biochemical markers with mortality in head trauma patients with decompressive craniotomy. METHODS: Ninety six patients with acute subdural hematoma underwent decompressive craniectomy between January 2014 and December 2015. The clinical data and laboratory variables of these patients were recorded and analyzed retrospectively...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27856148/evaluation-of-benign-paroxysmal-positional-vertigo-following-le-fort-i-osteotomy
#19
K Deniz, S S Akdeniz, A Ö Koç, S Uçkan, L N Ozluoğlu
The Le Fort I osteotomy is widely used to correct dentofacial deformities. Benign paroxysmal positional vertigo (BPPV) is a common vestibular end organ disorder characterized by short, often recurrent episodes of vertigo. Head trauma is one of the known causes of BPPV. During pterygoid osteotomy, the surgical trauma induced by percussion with the surgical mallet and osteotomes can displace otoliths into the semicircular canal, resulting in BPPV. The aim of this study was to evaluate the potential risk of occurrence of BPPV in individuals undergoing Le Fort I osteotomy...
November 14, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27853132/traumatic-brain-injuries
#20
Kaj Blennow, David L Brody, Patrick M Kochanek, Harvey Levin, Ann McKee, Gerard M Ribbers, Kristine Yaffe, Henrik Zetterberg
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available...
November 17, 2016: Nature Reviews. Disease Primers
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