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https://www.readbyqxmd.com/read/29619424/liver-stiffness-measurement-predicted-liver-related-events-and-all-cause-mortality-a-systematic-review-and-nonlinear-dose-response-meta-analysis
#1
Junna Wang, Jiajun Li, Quan Zhou, Dandan Zhang, Qiu Bi, Yulin Wu, Wenxiang Huang
Numerous studies have investigated the prognosis value of the liver stiffness measurement (LSM) by transient elastography in assessing the risk of liver-related events (LREs) and all-cause mortality in patients with chronic liver disease (CLD). However, the shape of the dose-response relationship between them remains unclear. We searched PubMed, Embase, the Cochrane Library, and reference lists of articles for studies published up to July 1, 2017, that assessed the LSM in predicting LREs and all-cause mortality among subjects with CLD...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29595065/protease-inhibitor-therapy-for-hepatitis-c-virus-infection
#2
P de Leuw, C Stephan
The hepatitis C virus (HCV) has affected an estimated of 80 million individuals worldwide and is a strain on public health. Around 25-30% of patients in Europe and the US who are infected with HIV are coinfected with HCV. Prior to 2013, treatment modalities containing an NS3/4A protease inhibitor in combination with pegylated interferon and ribavirin improved sustained virological response (SVR) rates. However, rates of severe side effects were high. Nowadays, oral direct-acting antiviral (DAA) combination therapy offers excellent treatment efficacy, safety and tolerability...
April 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29577515/impact-of-previous-hepatitis-b-infection-on-the-clinical-outcomes-from-chronic-hepatitis-c-a-population-level-analysis
#3
H Wang, R Swann, E Thomas, H A Innes, H Valerio, P C Hayes, S Allen, S T Barclay, D Wilks, R Fox, D Bhattacharyya, N Kennedy, J Morris, A Fraser, A J Stanley, R Gunson, P G Mclntyre, A Hunt, S J Hutchinson, P R Mills, J F Dillon
Chronic coinfection with hepatitis C virus (HCV) and hepatitis B virus (HBV) is associated with adverse liver outcomes. The clinical impact of previous HBV infection on liver disease in HCV infection is unknown. We aimed at determining any association of previous HBV infection with liver outcomes using antibodies to the hepatitis B core antigen (HBcAb) positivity as a marker of exposure. The Scottish Hepatitis C Clinical Database containing data for all patients attending HCV clinics in participating health boards was linked to the HBV diagnostic registry and mortality data from Information Services Division, Scotland...
March 25, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29532619/effect-of-hepatitis-b-virus-on-steatosis-in-hepatitis-c-virus-co-infected-subjects-a-multi-center-study-and-systematic-review
#4
Nicolas Goossens, Claudio de Vito, Alessandra Mangia, Sophie Clément, Giovanni Cenderello, Francisco Barrera, Roberta D'Ambrosio, Nicola Coppola, Rosa Zampino, Maria Stanzione, Luigi Elio Adinolfi, Heiner Wedemeyer, Nasser Semmo, Beat Müllhaupt, David Semela, Raffaele Malinverni, Darius Moradpour, Markus Heim, Gaia Trincucci, Laura Rubbia-Brandt, Francesco Negro
It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-center cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls...
March 13, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29487874/epidemiological-profile-and-risk-factors-for-acquiring-hbv-and-or-hcv-in-hiv-infected-population-groups-in-nepal
#5
Manjula Bhattarai, Jagat Bahadur Baniya, Nirmal Aryal, Bimal Shrestha, Ramanuj Rauniyar, Anurag Adhikari, Pratik Koirala, Pardip Kumar Oli, Ram Deo Pandit, David A Stein, Birendra Prasad Gupta
HBV and HCV infections are widespread among the HIV-infected individuals in Nepal. The goals of this study were to investigate the epidemiological profile and risk factors for acquiring HBV and/or HCV coinfection in disadvantaged HIV-positive population groups in Nepal. We conducted a retrospective study on blood samples from HIV-positive patients from the National Public Health Laboratory at Kathmandu to assay for HBsAg, HBeAg, and anti-HCV antibodies, HIV viral load, and CD4+ T cell count. Among 579 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV coinfections was 3...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29434450/incidence-of-hepatocellular-carcinoma-in-patients-with-chronic-liver-disease-due-to-hepatitis-b-or-c-and-coinfected-with-the-human-immunodeficiency-virus-a-retrospective-cohort-study
#6
Patrícia Dos Santos Marcon, Cristiane Valle Tovo, Dimas Alexandre Kliemann, Patrícia Fisch, Angelo Alves de Mattos
AIM: To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS: A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29404490/survival-following-hospitalization-with-hepatocellular-carcinoma-among-people-notified-with-hepatitis-b-or-c-virus-in-australia-2000-2014
#7
Reem Waziry, Jason Grebely, Janaki Amin, Maryam Alavi, Behzad Hajarizadeh, Jacob George, Gail V Matthews, Matthew Law, Gregory J Dore
We assessed trends in HCC survival in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in New South Wales, Australia. Data on HBV (n = 54,399) and HCV (n = 96,908) notifications (1993-2012) were linked to a hospitalization database (July 2000-June 2014), the New South Wales Cancer Registry, and the New South Wales Death Registry. A total of 725 (1.3%) first HBV-hepatocellular carcinoma (HCC) and 1,309 (1.4%) first HCV-HCC hospitalizations were included. Death occurred in 60.4% of HBV-HCC and 69...
October 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29397016/risk-of-hepatitis-b-virus-reactivation-in-hepatitis-b-virus-hepatitis-c-virus-co-infected-patients-with-compensated-liver-cirrhosis-treated-with-ombitasvir-paritaprevir-r-dasabuvir-ribavirin
#8
C M Preda, C P Popescu, C Baicus, I Constantinescu, A Oproiu, T Voiosu, M Diculescu, L Negreanu, L Gheorghe, I Sporea, A Trifan, E Ceausu, D Proca, M Manuc
Hepatitis B virus may reactivate in patients with chronic hepatitis C treated with direct-acting antivirals. The aim of this study was to investigate the risk of hepatitis B virus (HBV) reactivation in HBV + hepatitis C virus (HCV)-co-infected patients with compensated liver cirrhosis treated with paritaprevir/ombitasvir/ritonavir, dasabuvir with ribavirin. We reviewed prospectively gathered data from a national cohort of 2070 hepatitis C virus patients with compensated liver cirrhosis who received reimbursed paritaprevir/ombitasvir/r, dasabuvir with ribavirin for 12 weeks from the Romanian National Health Agency during 2015-2016...
February 3, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29371017/hepatitis-b-virus-reactivation-during-direct-acting-antiviral-therapy-for-hepatitis-c-a-systematic-review-and-meta-analysis
#9
Marcus M Mücke, Lisa I Backus, Victoria T Mücke, Nicola Coppola, Carmen M Preda, Ming-Lun Yeh, Lydia S Y Tang, Pamela S Belperio, Eleanor M Wilson, Ming-Lung Yu, Stefan Zeuzem, Eva Herrmann, Johannes Vermehren
BACKGROUND: Direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection might pose a risk for hepatitis B virus (HBV) reactivation in patients coinfected with chronic or resolved HBV infection. The need for HBV antiviral prophylaxis during DAA treatment remains controversial. We aimed to analyse the absolute risk of HBV reactivation in patients with active or resolved HBV infection treated with DAAs for HCV infection. METHODS: For this systematic review and meta-analysis, we searched PubMed, Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, and Web of Science from Oct 1, 2010, to Sept 30, 2017, to identify studies of patients with chronic or resolved HBV infection at baseline treated with DAAs for chronic HCV infection...
January 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29369303/report-from-the-international-conference-on-viral-hepatitis-2017
#10
Vicente Soriano, Benjamin Young, Nancy Reau
The International Conference on Viral Hepatitis 2017 brought exciting news on the treatment of viral hepatitis. The most recent estimates of the burden for hepatitis B virus and hepatitis C virus (HCV) infections were presented. The current gaps and prospects for regional and global eradication of viral hepatitis were discussed on the light of the WHO roadmap until 2030. Debates focused on hepatitis C and expectations using the new approved HCV pan-genotypic, once daily, oral direct-acting antivirals (DAAs), glecaprevir-pibrentasvir, and sofosbuvir-velpatasvir-voxilaprevir...
January 25, 2018: AIDS Reviews
https://www.readbyqxmd.com/read/29322398/hepatitis-c-virus-infection-and-development-of-type-2-diabetes-mellitus-systematic-review-and-meta-analysis-of-the-literature
#11
REVIEW
Silvia Fabiani, Poupak Fallahi, Silvia Martina Ferrari, Mario Miccoli, Alessandro Antonelli
Type 2 diabetes mellitus (T2DM) is an endocrine disorder encompassing multifactorial mechanisms, and chronic hepatitis C virus infection (CHC) is a multifaceted disorder, associated with extrahepatic manifestations, including endocrinological disorders. CHC and T2DM are associated, but the subject remains controversial. We performed a systematic review and meta-analysis evaluating such association, searching on PubMed until February 29, 2016. Inclusion criteria were: 1) presence of at least one internal control group age- and gender-matched (non-hepatopathic controls; and/or hepatopathic, not HCV-positive, controls); 2) sufficient data to calculate odds ratio and relative risk...
January 11, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29299894/human-immunodeficiency-virus-hiv-and-hepatitis-virus-coinfection-among-hiv-infected-korean-patients-the-korea-hiv-aids-cohort-study
#12
Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, Jun Yong Choi
BACKGROUND: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29287028/hbv-or-hcv-coinfection-in-hiv-1-infected-pregnant-women-in-france-prevalence-and-pregnancy-outcomes
#13
Valérie Benhammou, Roland Tubiana, Sophie Matheron, Pierre Sellier, Laurent Mandelbrot, Jérôme Le Chenadec, Emmanuelle Marel, Babak Khoshnood, Josiane Warszawski
BACKGROUND: Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is frequent in HIV-infected persons but their impact on pregnant HIV-infected women is understudied. We explored whether these coinfections are associated with adverse pregnancy outcomes and lower response to antiretroviral therapy (ART). METHODS: Pregnancies in HIV-1-infected women included in the ANRS French Perinatal Cohort between 2005 and 2013 were analyzed if HBV and HCV infection statuses were available...
April 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29238510/epidemiology-transmission-diagnosis-and-outcome-of-hepatitis-c-virus-infection
#14
REVIEW
Seyed Hamid Moosavy, Parivash Davoodian, Mirza Ali Nazarnezhad, Abdolazim Nejatizaheh, Ebrahim Eftekhar, Hamidreza Mahboobi
Hepatitis C infection is one of the main causes of chronic liver disorders worldwide. Nearly three percent (3%) of the world population has an HCV infection. Prevalence of HCV infection was higher in some groups such as injected drug users (IDUs) and HIV positive populations. Acute hepatitis has proven asymptomatic in most cases, and delay of diagnosis might lead to late onset of hepatocellular carcinoma and cirrhosis. Some host characteristics such as age, gender, body mass index, and viral properties are associated with HCV outcome hepatitis...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238229/coinfections-with-hepatitis-b-and-c-virus-and-syphilis-among-hiv-infected-clients-in-southern-ethiopia-a-cross-sectional-study
#15
Techalew Shimelis, Yayheyirad Tassachew, Agete Tadewos, Mesfin Worku Hordofa, Anteneh Amsalu, Birkneh Tilahun Tadesse, Endale Tadesse
Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses of public health significance worldwide. Despite their severe clinical impact in HIV-infected patients, there is inadequate information regarding the epidemiology of hepatitis/HIV coinfections in Ethiopia. Thus, this study aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients at a tertiary hospital in Southern Ethiopia. Methods: Stored sera, which were originally collected for the investigation of syphilis among HIV-infected clients, were analyzed in this study...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29201776/viral-hepatitis-and-liver-diseases-in-mongolia
#16
REVIEW
Oidov Baatarkhuu, G Uugantsetseg, D Munkh-Orshikh, N Naranzul, S Badamjav, D Tserendagva, J Amarsanaa, Kim Do Young
Mongolia is known for its high endemicity for viral hepatitis. Previous studies report that the seroprevalence of hepatitis B virus (HBV) is 11.8% (178/1,512) among the unvaccinated population in 13 provinces and Ulaanbaatar city. The serosurvey of adults (>20 years of age) conducted during 2013 among persons in four provinces and in Ulaanbaatar showed that the overall prevalence of hepatitis B surface antigen (HBsAg) positivity was 10.6%. The overall prevalence of anti-hepatitis C virus (HCV) and HCV ribonucleic acid among 1,512 apparently healthy subjects was 15...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29178465/detection-of-human-immunodeficiency-virus-hepatitis-c-virus-and-hepatitis-b-virus-in-postmortem-blood-specimens-using-infectious-disease-assays-licensed-for-cadaveric-donor-screening
#17
Melissa A Greenwald, Stephen Kerby, Kori Francis, Anna C Noller, William T Gormley, Robin Biswas, Richard A Forshee
BACKGROUND: Evaluation of assay performance on postmortem blood specimens (obtained after cessation of the heartbeat) presents unique scientific and regulatory challenges. In the United States, assay performance is evaluated in part by spiking postmortem specimens. METHODS: Fifty-four specimens obtained from decedents known to be infected with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B virus (HBV), including some coinfections, were tested for each virus using Food and Drug Administration (FDA)-licensed donor screening tests for nucleic acid, antibody, and antigen...
February 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29174546/efficacy-of-ledipasvir-and-sofosbuvir-treatment-of-hcv-infection-in-patients-coinfected-with-hbv
#18
Chun-Jen Liu, Wan-Long Chuang, I-Shyan Sheen, Horng-Yuan Wang, Chi-Yi Chen, Kuo-Chih Tseng, Ting-Tsung Chang, Benedetta Massetto, Jenny C Yang, Chohee Yun, Steven J Knox, Anu Osinusi, Gregory Camus, Deyuan Jiang, Diana M Brainard, John G McHutchison, Tsung-Hui Hu, You-Chun Hsu, Gin-Ho Lo, Chi-Jen Chu, Jyh-Jou Chen, Cheng-Yuan Peng, Ron-Nan Chien, Pei-Jer Chen
BACKGROUND & AIMS: There have been reports of reactivation of hepatitis B virus (HBV) infection during treatment of hepatitis C virus (HCV) infection with direct-acting antiviral agents. We performed a prospective study of risks and outcomes of HCV infection treatment with ledipasvir and sofosbuvir in patients with HBV infection. METHODS: We performed a phase 3b, multicenter, open-label study in Taiwan of 111 patients with HCV infection (61% HCV genotype 1, 39% HCV genotype 2 infection; 62% women, 16% with compensated cirrhosis) along with HBV infection...
November 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29161880/hiv-hepatitis-b-virus-and-hepatitis-c-virus-prevalence-among-high-risk-populations-in-south-india
#19
Thongadi Ramesh Dinesha, Jayaseelan Boobalan, Sathasivam Sivamalar, Sunil S Solomon, Selvamuthu Poongulali, Ambrose Pradeep, Kailapuri G Murugavel, Pachamuthu Balakrishnan, Davey M Smith, Shanmugam Saravanan
No abstract text is available yet for this article.
January 17, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29143625/trends-in-hepatitis-b-virus-testing-practices-and-management-in-hiv-clinics-across-sub-saharan-africa
#20
REVIEW
Patrick A Coffie, Matthias Egger, Michael J Vinikoor, Marcel Zannou, Lameck Diero, Akouda Patassi, Mark H Kuniholm, Moussa Seydi, Guillaume Bado, Ponsiano Ocama, Monique I Andersson, Eugène Messou, Albert Minga, Philippa Easterbrook, Kathryn Anastos, François Dabis, Gilles Wandeler
BACKGROUND: Approximately 8% of HIV-infected individuals are co-infected with hepatitis B virus (HBV) in sub-Saharan Africa (SSA). Knowledge of HBV status is important to guide optimal selection of antiretroviral therapy (ART) and monitor/prevent liver-related complications. We describe changes in testing practices and management of HBV infection over a 3-year period in HIV clinics across SSA. METHODS: A medical chart review was conducted in large urban HIV treatment centers in Côte d'Ivoire (3 sites), Benin, Burkina Faso, Cameroon, Kenya, Senegal, South Africa, Togo, Uganda and Zambia (1 site each)...
November 1, 2017: BMC Infectious Diseases
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