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https://www.readbyqxmd.com/read/29201776/viral-hepatitis-and-liver-diseases-in-mongolia
#1
REVIEW
Oidov Baatarkhuu, G Uugantsetseg, D Munkh-Orshikh, N Naranzul, S Badamjav, D Tserendagva, J Amarsanaa, Kim Do Young
Mongolia is known for its high endemicity for viral hepatitis. Previous studies report that the seroprevalence of hepatitis B virus (HBV) is 11.8% (178/1,512) among the unvaccinated population in 13 provinces and Ulaanbaatar city. The serosurvey of adults (>20 years of age) conducted during 2013 among persons in four provinces and in Ulaanbaatar showed that the overall prevalence of hepatitis B surface antigen (HBsAg) positivity was 10.6%. The overall prevalence of anti-hepatitis C virus (HCV) and HCV ribonucleic acid among 1,512 apparently healthy subjects was 15...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29178465/detection-of-human-immunodeficiency-virus-hepatitis-c-virus-and-hepatitis-b-virus-in-post-mortem-blood-specimens-using-infectious-disease-assays-licensed-for-cadaveric-donor-screening
#2
Melissa A Greenwald, Stephen Kerby, Kori Francis, Anna C Noller, William T Gormley, Robin Biswas, Richard A Forshee
BACKGROUND: Evaluation of assay performance on post-mortem blood specimens (obtained after cessation of the heartbeat) presents unique scientific and regulatory challenges. In the United States, assay performance is evaluated in part by spiking postmortem specimens. METHODS: Fifty-four specimens obtained from decedents known to be infected with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B virus (HBV), including some coinfections, were tested for each virus using Food and Drug Administration (FDA)-licensed donor screening tests for nucleic acid, antibody, and antigen...
November 27, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29174546/efficacy-of-ledipasvir-and-sofosbuvir-treatment-of-hcv-infection-in-patients-coinfected-with-hbv
#3
Chun-Jen Liu, Wan-Long Chuang, I-Shyan Sheen, Horng-Yuan Wang, Chi-Yi Chen, Kuo-Chih Tseng, Ting-Tsung Chang, Benedetta Massetto, Jenny C Yang, Chohee Yun, Steven J Knox, Anu Osinusi, Gregory Camus, Deyuan Jiang, Diana M Brainard, John G McHutchison, Tsung-Hui Hu, You-Chun Hsu, Gin-Ho Lo, Chi-Jen Chu, Jyh-Jou Chen, Cheng-Yuan Peng, Ron-Nan Chien, Pei-Jer Chen
BACKGROUND & AIMS: There have been reports of reactivation of hepatitis B virus (HBV) infection during treatment of hepatitis C virus (HCV) infection with direct-acting antiviral agents. We performed a prospective study of risks and outcomes of HCV infection treatment with ledipasvir and sofosbuvir in patients with HBV infection. METHODS: We performed a phase 3b, multicenter, open-label study in Taiwan of 111 patients with HCV infection (61% HCV genotype 1, 39% HCV genotype 2 infection; 62% women, 16% with compensated cirrhosis) along with HBV infection...
November 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29161880/hiv-hbv-and-hcv-prevalence-among-high-risk-populations-in-south-india
#4
Thongadi Ramesh Dinesha, Jayaseelan Boobalan, Sathasivam Sivamalar, Sunil S Solomon, Selvamuthu Poongulali, Ambrose Pradeep, Kailapuri G Murugavel, Balakrishnan Pachamuthu, Davey M Smith, Shanmugam Saravanan
HBV and HCV coinfection with HIV has become a major concern for the survival of HIV patients. HBV, HCV coinfection with HIV is less reported in risk population especially in India. Persons presenting for HIV testing at a large testing center in Chennai, India were screened for HIV, HBV, and HCV infections with serologic testing. Prevalence of these infections was compared between heterosexual and injection drugs using (IDU) risk groups. Of 1612 persons presenting for testing, 502 (31%) were HIV infected, 131 (8%) were HBV infected and 618 (38%) were HCV infected...
November 22, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29143625/trends-in-hepatitis-b-virus-testing-practices-and-management-in-hiv-clinics-across-sub-saharan-africa
#5
REVIEW
Patrick A Coffie, Matthias Egger, Michael J Vinikoor, Marcel Zannou, Lameck Diero, Akouda Patassi, Mark H Kuniholm, Moussa Seydi, Guillaume Bado, Ponsiano Ocama, Monique I Andersson, Eugène Messou, Albert Minga, Philippa Easterbrook, Kathryn Anastos, François Dabis, Gilles Wandeler
BACKGROUND: Approximately 8% of HIV-infected individuals are co-infected with hepatitis B virus (HBV) in sub-Saharan Africa (SSA). Knowledge of HBV status is important to guide optimal selection of antiretroviral therapy (ART) and monitor/prevent liver-related complications. We describe changes in testing practices and management of HBV infection over a 3-year period in HIV clinics across SSA. METHODS: A medical chart review was conducted in large urban HIV treatment centers in Côte d'Ivoire (3 sites), Benin, Burkina Faso, Cameroon, Kenya, Senegal, South Africa, Togo, Uganda and Zambia (1 site each)...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29140988/sex-difference-in-the-interaction-of-alcohol-intake-hepatitis-b-virus-and-hepatitis-c-virus-on-the-risk-of-cirrhosis
#6
Tommaso Stroffolini, Evangelista Sagnelli, Angelo Andriulli, Guido Colloredo, Caterina Furlan, Giovanni Battista Gaeta, Filomena Morisco, Mario Pirisi, Floriano Rosina, Caterina Sagnelli, Antonina Smedile, Piero Luigi Almasio
BACKGROUND: The joint effect of the interaction of alcohol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) on the risk of cirrhosis is still unexplored because a large sample size is required for this investigation. OBJECTIVE: Evaluation of interaction of HBV, HCV and alcohol abuse on the risk of cirrhosis. DESIGN: We analysed 12,262 consecutive patients with chronic liver disease of various aetiologies referring to 95 Italian liver units in 2001 or 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29081251/an-update-on-the-treatment-options-for-hbv-hcv-coinfection
#7
Evangelista Sagnelli, Caterina Sagnelli, Margherita Macera, Mariantonietta Pisaturo, Nicola Coppola
Despite the reciprocal inhibition exerted by HBV and HCV genomes, dual HBV/HCV infection is associated with more severe forms of liver disease and warrant effective treatment. Areas covered: A careful evaluation of disease progression to establish the predominance of one virus over another, concomitant HIV infection and comorbidities is essential to make the best therapy choices. In most virological conditions interferon (IFN)-based treatment has been replaced by a combination of different classes of second generation directly acting antivirals (DAAs), which offer better tolerability and HCV eradication in 95% of cases...
November 2, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29027728/hepatitis-in-aids-patients
#8
REVIEW
Muhammad Imran Qadir
The individuals with HIV infection are more susceptible to develop coinfections with infectious pathogens such as HCV and HBV. The routes of transmission of these pathogens are the same including sexual contact, injection drug use, or at birth from mother to an infant. The main reason of morbidity and mortality in HIV infected individuals is a liver disease in the context of antiretroviral therapy, and coinfection such as HCV and HBV complicates this condition. Nucleos(t)ide analogues are used for HBV infection management, and treatment of HCV infection is done by PegIFN and ribavirin combination and protease inhibitors...
October 13, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28994127/the-negative-impact-of-hbv-hcv-coinfection-on-cirrhosis-and-its-consequences
#9
S Pol, G Haour, H Fontaine, C Dorival, V Petrov-Sanchez, M Bourliere, J Capeau, P Carrieri, D Larrey, C Larsen, P Marcellin, J-M Pawlostky, P Nahon, F Zoulim, P Cacoub, V de Ledinghen, P Mathurin, F Negro, G-P Pageaux, Y Yazdanpanah, L Wittkop, J-P Zarski, F Carrat
BACKGROUND: Hepatitis B virus (HBV)/hepatitis C virus (HCV) confection has been rarely studied in nonasian series. AIM: To compare the characteristics of HBV/HCV coinfected patients to those of HBV- or HCV-monoinfected patients in the ANRS CO22 HEPATHER cohort study. PATIENTS AND METHODS: Of the 20 936 included patients, 95 had HBV/HCV coinfection (hepatitis B surface antigen, anti-HCV antibody and HCV RNA positive) and were matched with 375 HBV- and 380 HCV-monoinfected patients on age, gender and time since HBV or HCV diagnosis...
October 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28965214/serological-and-molecular-markers-of-hepatitis-e-virus-infection-in-hiv-infected-patients-in-brazil
#10
A C Ferreira, Michele Soares Gomes-Gouvêa, G Lisboa-Neto, M C J Mendes-Correa, C M Picone, N A Salles, A Mendrone-Junior, F J Carrilho, J R R Pinho
In Brazil, the circulation of hepatitis E virus (HEV) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (HIV) infection is unknown. This study aimed to assess the frequency of serological and molecular HEV markers in individuals infected with HIV from São Paulo, Brazil. Serum and plasma samples of 354 HIV-infected patients collected between 2007 and 2013 were included. All samples were tested for anti-HEV IgG and IgM antibodies and HEV RNA...
September 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28954067/profile-of-hiv-subtypes-in-hiv-hbv-and-hiv-hcv-coinfected-patients-in-southern-brazil
#11
Valéria Miranda Avanzi, Bianca Arão Vicente, Nayara Carvalho Polido Beloto, Monica Maria Gomes-da-Silva, Clea Elisa Lopes Ribeiro, Felipe Francisco Tuon, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Sonia Mara Raboni
INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28951779/cd4-t-cells-and-natural-killer-cells-biomarkers-for-hepatic-fibrosis-in-human-immunodeficiency-virus-hepatitis-c-virus-coinfected-patients
#12
Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner, Jorge Quarleri
AIM: To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. METHODS: Peripheral mononuclear cells from 24 HIV/HCV (HBV negative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28951598/prevalence-and-predictors-of-liver-disease-in-hiv-infected-children-and-adolescents
#13
Maria Pokorska-Śpiewak, Aleksandra Stańska-Perka, Jolanta Popielska, Agnieszka Ołdakowska, Urszula Coupland, Konrad Zawadka, Małgorzata Szczepańska-Putz, Magdalena Marczyńska
Liver disease in HIV-infected patients may result from the infection itself, antiretroviral treatment or comorbidities. In this study, we analysed liver disease in 79 HIV-infected children and adolescents aged 14.0 ± 5.1 years. All the patients were receiving combination antiretroviral therapy (cART), with a mean duration of 11.5 ± 4.7 years. Six patients (8%) had detectable HIV viral load, and 8/79 (10%) of the participants were coinfected with hepatitis B or C virus (HCV, 6/8 or HBV, 2/8). Liver disease was defined as an elevation of any of the following parameters: alanine or aspartate aminotransferase (ALT and AST), total bilirubin, and gamma glutamyl transferase (GGTP)...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28947403/hepatitis%C3%A2-b-c-and-e-infection-among-hiv-infected-patients-in-franceville-gabon-retrospective-cross-sectional-study
#14
B Bivigou-Mboumba, F Rouet, A Mouinga-Ondeme, L Deleplancque, J Sica, A Ndjoyi-Mbiguino, R Njouom, S François-Souquière
Access to antiretrovirals has increased the life expectancy of patients living with HIV. However, HIV-viral hepatitis coinfections in countries endemic for these infections make management more difficult. To determine the extent of these coinfections in Gabon, we investigated markers of hepatitis B, C, and E viruses in 762 adults infected with HIV-1 by ELISA. We used real-time PCR to quantify plasma HBV DNA (HBV VL) and amplified HCV and HEV RNA by nested RT-PCR and PCR.The seroprevalence of chronic hepatitis B infection was 9...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28935244/contribution-of-hepatitis-b-virus-and-hepatitis-c-virus-to-liver-cancer-in-china-north-areas-experience-of-the-chinese-national-cancer-center
#15
Minjie Wang, Yuting Wang, Xiaoshuang Feng, Ruijun Wang, Yanmei Wang, Hongmei Zeng, Jun Qi, Hong Zhao, Ni Li, Jianqiang Cai, Chunfeng Qu
INTRODUCTION: The aim of this study was to determine the impact of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) on primary liver cancer (PLC) in China north areas. METHODS: A total of 2172 histologically confirmed PLC patients attending the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences during the period January 1, 2003 to December 31, 2014 were enrolled. Details of hepatitis B surface antigen (HBsAg), antibodies against HBV core antigen (anti-HBc), and antibodies against HCV (anti-HCV) status were recorded...
September 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28921677/clinical-profile-of-hepatitis-c-virus-infection-in-a-developing-country-india
#16
Ramit Mahajan, Vandana Midha, Omesh Goyal, Varun Mehta, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Dharmatma Singh, Rishu Bhanot, Ajit Sood
BACKGROUND: The epidemiology and clinical profile of hepatitis C virus (HCV) varies worldwide and data from developing countries is sparse. AIMS: To study the clinical profile of HCV infection in a developing country in South East Asia (India). METHODS: This observational study assessed patient demographics, viral characteristics, risk factors for virus acquisition and disease characteristics in HCV patients diagnosed between January 2004 and December 2015...
September 18, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28856290/recommendations-for-the-treatment-of-hepatitis-c-in-2017
#17
REVIEW
Waldemar Halota, Robert Flisiak, Jacek Juszczyk, Piotr Małkowski, Małgorzata Pawłowska, Krzysztof Simon, Krzysztof Tomasiewicz
The goals of treatment is to eliminate HCV infection, stop or reverse histological changes, reduce the risk of hepatocellular carcinoma development and transmission of the infection to other individuals. According to the recommendation of the Polish Group of Experts for HCV in 2017 all patients with chronic HCV infection should receive treatment, but it is not recommended in patients at high risk of short overall survival. If access to therapy is restricted, priority should be given to patients whose HCV infection can lead to an unfavourable outcome of the disease within a short time frame, particular to individuals with liver cirrhosis, rapidly progressing liver fibrosis, extrahepatic manifestations of HCV infection, chronic kidney diseases, patients before and after organ transplantation...
June 2017: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/28856286/hepatitis-d-b-and-c-virus-hdv-hbv-hcv-coinfection-as-a-diagnostic-problem-and-therapeutic-challenge
#18
Beata Lorenc, Katarzyna Sikorska, Piotr Stalke, Krzysztof Bielawski, Dominik Ziętkowski
Coinfection with hepatitis D virus (HDV) in chronic hepatitis B is associated with more rapid progression to liver cirrhosis. We present two cases of infection with hepatitis D, B and C viruses. Both male patients were primarily diagnosed as infected with hepatitis B virus (HBV) and hepatitis C virus (HCV), HBsAg-positive and anti-HCV-positive. The first patient was treated with interferon, lamivudine and pegylated interferon. A full virological and biochemical response was achieved. The second patient was treated with interferon and ribavirin, lamivudine and twice with pegylated interferon...
March 2017: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/28829824/a-syndemic-approach-to-assess-the-effect-of-substance-use-and-social-disparities-on-the-evolution-of-hiv-hcv-infections-in-british-columbia
#19
Zahid Ahmad Butt, Nabin Shrestha, Stanley Wong, Margot Kuo, Dionne Gesink, Mark Gilbert, Jason Wong, Amanda Yu, Maria Alvarez, Hasina Samji, Jane A Buxton, James C Johnston, Victoria J Cook, David Roth, Theodora Consolacion, Michelle Murti, Travis S Hottes, Gina Ogilvie, Robert Balshaw, Mark W Tyndall, Mel Krajden, Naveed Z Janjua
BACKGROUND: Co-occurrence of social conditions and infections may affect HIV/HCV disease risk and progression. We examined the changes in relationship of these social conditions and infections on HIV and hepatitis C virus (HCV) infections over time in British Columbia during 1990-2013. METHODS: The BC Hepatitis Testers Cohort (BC-HTC) includes ~1.5 million individuals tested for HIV or HCV, or reported as a case of HCV, HIV, HBV, or tuberculosis linked to administrative healthcare databases...
2017: PloS One
https://www.readbyqxmd.com/read/28774413/management-of-hepatitis-b-in-special-populations
#20
REVIEW
Kali Zhou, Norah Terrault
Special populations infected with chronic HBV include those with decompensated cirrhosis, coinfections (HIV, HCV, HDV), hemodialysis and renal failure, immunosuppressed including transplant patients, children and women in pregnancy. These populations differ in their natural history and risk for liver-related complications, the indications for anti-HBV therapy as well as the recommendations regarding the HBV drugs used, duration of therapy and anticipated endpoints. Reflecting the special populations with substantive changes in management in recent years, this review focuses on HBV-HIV coinfected patients, immunosuppressed patients at risk for reactivation, liver transplant recipients and pregnant women...
June 2017: Best Practice & Research. Clinical Gastroenterology
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