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https://www.readbyqxmd.com/read/28444158/reactivation-of-hepatitis-b-virus-following-treatment-of-hepatitis-c-virus-infection-in-coinfected-patients
#1
Resat Ozaras, Ilker Inanc Balkan, Mucahit Yemisen, Bilgul Mete, Fehmi Tabak
No abstract text is available yet for this article.
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28362065/alcohol-use-viral-hepatitis-and-liver-fibrosis-among-hiv-positive-persons-in-west-africa-a-cross-sectional-study
#2
Antoine Jaquet, Gilles Wandeler, Marcellin Nouaman, Didier K Ekouevi, Judicaël Tine, Akouda Patassi, Patrick A Coffie, Aristophane Tanon, Moussa Seydi, Alain Attia, François Dabis
INTRODUCTION: Liver fibrosis is often the first stage of liver disease in people living with HIV (PLWHIV) in industrialized countries. However, little is known about liver fibrosis and its correlates among PLWHIV in sub-Saharan Africa. METHODS: The study was undertaken in three HIV referral clinics in Côte d'Ivoire, Senegal and Togo. Enrolled PLWHIV underwent a non-invasive assessment of liver fibrosis combining liver stiffness measure (LSM) with transient elastography and the aspartate aminotransferase-to-platelet ratio index (APRI)...
February 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28343937/co-infection-of-blood-borne-viruses-in-blood-donors-a-cross-sectional-study-from-north-india
#3
Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Ganesh Singh Rawat, Jyoti Sharma, Devi Prasad Acharya, Gunjan Bhardwaj
BACKGROUND: There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors. MATERIALS AND METHODS: The cross-sectional analysis was conducted in blood donors. All donors were tested for anti-HIV I and II, HBsAg, anti-HBC IgM, anti-HCV, Malaria and syphilis by chemiluminescence and ID-NAT assay...
March 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28306597/diagnosis-of-viral-hepatitis
#4
Philippa J Easterbrook, Teri Roberts, Anita Sands, Rosanna Peeling
PURPOSE OF REVIEW: Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and HIV-HBV and HCV coinfection are major causes of chronic liver disease worldwide. Testing and diagnosis is the gateway for access to both treatment and prevention services, but there remains a large burden of undiagnosed infection globally. We review the global epidemiology, key challenges in the current hepatitis testing response, new tools to support the hepatitis global response (2016-2020 Global Hepatitis Health Sector strategy, and 2017 WHO guidelines on hepatitis testing) and future directions and innovations in hepatitis diagnostics...
May 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28296739/ugt1a1-28-relationship-with-abnormal-total-bilirubin-levels-in-chronic-hepatitis-c-patients-outcomes-from-a-case-control-study
#5
Marcelo Moreira Tavares de Souza, Victor Van Vaisberg, Rodrigo Martins Abreu, Aline Siqueira Ferreira, Camila daSilvaFerreira, Paulo Dominguez Nasser, Helena Scavone Paschoale, Flair José Carrilho, Suzane Kioko Ono
Gilbert syndrome (GS) is a frequent benign clinical condition, marked by intermittent unconjugated hyperbilirubinemia, mostly due to the polymorphism uridine diphosphate-glucuronosyltransferase 1A1*28 (UGT1A1*28). Hyperbilirubinemia has been reported in a GS patient undergoing hepatitis C treatment, and other UGT isoforms polymorphisms have been linked to worse outcomes in viral hepatitis. Yet, little is known to GS contributions' to the liver disease scenario. Our aim was to assess UGT1A1 genotypes' frequency in chronic hepatitis C (CHC) patients and correlate with total bilirubin (TB)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28248445/prevalence-and-distribution-of-hepatitis-c-virus-genotypes-in-spain-during-the-2000-2015-period-the-gehep-005-study
#6
Antonio Aguilera, Daniel Navarro, Francisco Rodríguez Frias, Isabel Viciana, Ana María Martínez-Sapiña, Mario José Rodríguez, Elisa Martró, María Del Carmen Lozano, Eleda Coletta, Laura Cardeñoso, Avelina Suárez, Matilde Trigo, Javier Rodríguez-Granjer, Natalia Montiel, Alberto de la Iglesia, Juan Carlos Alados, Cesar Vegas, Samuel Bernal, Felipe Fernández-Cuenca, María José Pena, Gabriel Reina, Silvia García-Bujalance, María Julia Echevarria, Laura Benítez, Sonia Pérez-Castro, Dolores Ocete, Isabel García-Arata, Carmen Guerrero, Manuel Rodríguez-Iglesias, Paz Casas, Federico García
AIM: We report the largest study on the prevalence and distribution of HCV genotypes in Spain (2000-2015), and we relate them with clinical, epidemiological and virological factors. METHODS: Patients from 29 hospitals in 10 autonomous communities (Andalusia, Aragon, Castilla-Leon, Catalonia, Galicia, Canary Islands, Madrid-Community, Valencian-Community, Murcia Region and Basque Country) have been studied. Annual distribution of HCV genotypes and subtypes, as well as gender, age, transmission route, HIV and/or HBV-coinfection, and treatment details were recorded...
March 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28239319/prevalence-of-hepatitis-b-hepatitis-c-and-human-immunodeficiency-viral-infections-in-patients-with-inflammatory-bowel-disease-in-north-india
#7
Parnita Harsh, Vipin Gupta, Saurabh Kedia, Sawan Bopanna, Sucharita Pilli, Surendernath, Govind Kumar Makharia, Vineet Ahuja
BACKGROUND/AIMS: Patients with inflammatory bowel disease (IBD) often require immunosuppressive therapy and blood transfusions and therefore are at a high risk of contracting infections due to hepatitis B (HBV) and hepatitis C (HCV) and human immunodeficiency virus (HIV). In the present study, we assessed the prevalence of these infections in patients with IBD. METHODS: This retrospective study included 908 consecutive patients with IBD (ulcerative colitis [UC], n=581; Crohn's disease [CD], n=327) who were receiving care at a tertiary care center...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28222098/multicenter-study-of-skin-rashes-and-hepatotoxicity-in-antiretroviral-na%C3%A3-ve-hiv-positive-patients-receiving-non-nucleoside-reverse-transcriptase-inhibitor-plus-nucleoside-reverse-transcriptase-inhibitors-in-taiwan
#8
Pei-Ying Wu, Chien-Yu Cheng, Chun-Eng Liu, Yi-Chien Lee, Chia-Jui Yang, Mao-Song Tsai, Shu-Hsing Cheng, Shih-Ping Lin, De-Yu Lin, Ning-Chi Wang, Yi-Chieh Lee, Hsin-Yun Sun, Hung-Jen Tang, Chien-Ching Hung
OBJECTIVES: Two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI (nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for antiretroviral-naive HIV-positive patients in Taiwan. The three most commonly used nNRTIs are nevirapine (NVP), efavirenz (EFV) and rilpivirine (RPV). This study aimed to determine the incidences of hepatotoxicity and skin rashes within 4 weeks of initiation of cART containing 1 nNRTI plus 2 NRTIs. METHODS: Between June, 2012 and November, 2015, all antiretroviral-naive HIV-positive adult patients initiating nNRTI-containing cART at 8 designated hospitals for HIV care were included in this retrospective observational study...
2017: PloS One
https://www.readbyqxmd.com/read/28202897/dual-infection-with-hepatitis-b-and-epstein-barr-virus-presenting-with-severe-jaundice-coagulopathy-and-hepatitis-b-virus-chronicity-outcome
#9
Sirish C Rao, Imran Ashraf, Fazia Mir, Sami Samiullah, Jamal A Ibdah, Veysel Tahan
BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B...
February 16, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28191540/hepatitis-c-in-cameroon-what-is-the-progress-from-2001-to-2016
#10
Borris Rosnay Tietcheu Galani, Richard Njouom, Paul Fewou Moundipa
Chronic hepatitis C is a major public health problem in sub-Saharan countries and particularly in Cameroon where the prevalence rate is around 7.6% in the age group of 55-59 years. Recent investigations into this infection allowed defining a national seroprevalence, characterizing virological and biological profiles of infected patients and identifying medicinal plants of potential interest in hepatitis C therapy. However, in Cameroon, no existing report currently presents a good overview of hepatitis C research in relation to these parameters...
December 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28105258/efficacy-and-safety-of-tenofovir-in-chronic-hepatitis-b-australian-real-world-experience
#11
Grace C Lovett, Tin Nguyen, David M Iser, Jacinta A Holmes, Robert Chen, Barbara Demediuk, Gideon Shaw, Sally J Bell, Paul V Desmond, Alexander J Thompson
AIM: To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting. METHODS: We performed a retrospective analysis of treatment outcomes among treatment-naïve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate (TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28071205/long-term-liver-diseases-after-initiation-of-antiretroviral-therapy-in-hiv-infected-patients-with-and-without-hbv-or-hcv-coinfection
#12
Sithakom Phusanti, Kwanhatai Manosudprasit, Somnuek Sungkanuparph
Coinfection of hepatitis B virus (HBV) or hepatitis C virus (HCV) with HIV is common and associated with increased mortality and increased risk of progression to chronic liver disease. We aimed to study long-term liver diseases after initiation of antiretroviral therapy (ART) in HIV-infected patients with and without HBV or HCV coinfection. A retrospective cohort of 92 patients (32 patients with HBV and/or HCV coinfection) was analyzed. Overall mean age was 38.3 years, and 54.3% were males. Immunological and virological responses were similar between the 2 groups ( P > ...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/27885757/role-of-primary-t-cell-immunodeficiency-and-hepatitis-b-coinfection-on-spontaneous-clearance-of-hepatitis-c-the-bc-hepatitis-testers-cohort
#13
N Islam, M Krajden, M Gilbert, P Gustafson, A Yu, M Kuo, M Chong, M Alvarez, J Wong, M W Tyndall, N Z Janjua
T-cell host immune response against hepatitis C virus (HCV) has been suggested to play an important role in determining HCV infection outcome. However, data from human studies are not available. This study examined the effect of primary T-cell deficiency along with other factors on the spontaneous clearance of HCV in a large population-based cohort in British Columbia, Canada. The BC Hepatitis Testers Cohort includes all individuals tested for HCV in BC in 1990-2013 linked with data on their medical visits, hospitalizations and prescription drugs...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27870801/relationship-between-uveitis-different-types-of-viral-hepatitis-and-liver-cirrhosis-a-12-year-nationwide-population-based-cohort-study
#14
Peng-Tai Tien, Chun-Ju Lin, Yi-Yu Tsai, Huan-Sheng Chen, De-Kuang Hwang, Chih-Hsin Muo, Jane-Ming Lin, Wen-Lu Chen
PURPOSE: This study investigates whether patients with viral hepatitis and cirrhosis are at risk of uveitis in the years following hepatitis. METHODS: We used data from Taiwan National Health Insurance system. The cases were patients newly diagnosed with viral hepatitis from 2000 to 2011. The end point of interest was a diagnosis of uveitis. A chi-square test was used for the difference of demographic characteristics between viral hepatitis and comparison. The risk of uveitis in hepatitis was stratified using Cox proportional hazard regression...
December 2016: Retina
https://www.readbyqxmd.com/read/27867437/sero-prevalence-and-correlates-of-hepatitis-b-and-c-co-infection-among-hiv-infected-individuals-in-two-regional-hospitals-in-cameroon
#15
Henry Namme Luma, Servais Albert Fiacre Bagnaka Eloumou, Domin Sone Majunda Ekaney, Fernando Kemta Lekpa, Olivier Donfack-Sontsa, Bertrand Hugo Mbatchou Ngahane, Yacouba Njankouo Mapoure
BACKGROUND: Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive. OBJECTIVE: We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals. METHODS: A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres...
2016: Open AIDS Journal
https://www.readbyqxmd.com/read/27858889/correlates-of-infection-and-molecular-characterization-of-blood-borne-hiv-hcv-and-hbv-infections-in-hiv-1-infected-inmates-in-italy-an-observational-cross-sectional-study
#16
MULTICENTER STUDY
Nunzia Sanarico, Stefania D'Amato, Roberto Bruni, Claudia Rovetto, Emanuela Salvi, Patrizia Di Zeo, Paola Chionne, Elisabetta Madonna, Giulio Pisani, Angela Costantino, Michele Equestre, Maria E Tosti, Alessandra Cenci, Maria T Maggiorella, Leonardo Sernicola, Emanuele Pontali, Alfredo Pansera, Rocco Quattrocchi, Sergio Carbonara, Fabio Signorile, Lorenzo Antonio Surace, Guido Federzoni, Elisa Garlassi, Giulio Starnini, Roberto Monarca, Sergio Babudieri, Maria Rapicetta, Maria G Pompa, Anna Caraglia, Barbara Ensoli, Anna R Ciccaglione, Stefano Buttò
Coinfection of blood-borne hepatitis B and hepatitis C viruses (HBV and HCV, respectively) in human immunodeficiency virus type 1 (HIV-1)-positive individuals frequently occurs in inmate population and peculiar viral strains and patterns of virological markers may be observed.Plasma from 69 HIV-1-positive inmates was obtained from 7 clinical centers connected with correctional centers in different towns in Italy. HIV, HBV, and HCV markers were tested by commercial assays. Virus genotyping was carried out by sequencing the protease and reverse transcriptase-encoding region (PR-RT region) for HIV and a region encompassing the NS5B gene for HCV and subsequent phylogenetic analysis...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27755152/hepatocellular-carcinoma-in-patients-with-hiv
#17
Imane El Dika, James J Harding, Ghassan K Abou-Alfa
PURPOSE OF REVIEW: Hepatocellular carcinoma (HCC) is becoming an important cause of mortality in patients with HIV, attributed to coinfection with hepatitis C virus, hepatitis B virus, and the longer survival advantage these patients are achieving after introducing the highly active antiretroviral therapy (HAART) regimens. RECENT FINDINGS: In addition to hepatitis infection, immunosuppression secondary to HIV infection, direct impact of the virus on liver parenchyma, and the use of hepatotoxic antiretroviral drugs, all contribute to HCC pathogenesis...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27750294/chronic-hepatitis-b-and-c-virus-infection-and-risk-for-non-hodgkin-lymphoma-in-hiv-infected-patients-a-cohort-study
#18
Qing Wang, Andrea De Luca, Colette Smith, Robert Zangerle, Helen Sambatakou, Fabrice Bonnet, Colette Smit, Philipp Schommers, Alicia Thornton, Juan Berenguer, Lars Peters, Vincenzo Spagnuolo, Adriana Ammassari, Andrea Antinori, Eugenia Quiros-Roldan, Cristina Mussini, Jose M Miro, Deborah Konopnicki, Jan Fehr, Maria A Campbell, Monique Termote, Heiner C Bucher
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27746337/hepatitis-delta-associated-mortality-in-hiv-hbv-coinfected-patients
#19
Charles Béguelin, Darius Moradpour, Roland Sahli, Franziska Suter-Riniker, Alexander Lüthi, Matthias Cavassini, Huldrych F Günthard, Manuel Battegay, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Dominique L Braun, Hansjakob Furrer, Andri Rauch, Gilles Wandeler
BACKGROUND & AIMS: Hepatitis delta virus (HDV) infection accelerates the progression of hepatitis B virus (HBV)-related liver disease. We assessed the epidemiological characteristics of HDV infection in the nationwide Swiss HIV Cohort Study and evaluated its impact on clinical outcomes. METHODS: All HIV-infected patients with a positive hepatitis B surface antigen test were considered and tested for anti-HDV antibodies. HDV amplification and sequencing were performed in anti-HDV-positive patients...
February 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/27596150/the-population-level-cascade-of-care-for-hepatitis-c-in-british-columbia-canada-the-bc-hepatitis-testers-cohort-bc-htc
#20
Naveed Z Janjua, Margot Kuo, Amanda Yu, Maria Alvarez, Stanley Wong, Darrel Cook, Jason Wong, Jason Grebely, Zahid A Butt, Hasina Samji, Alnoor Ramji, Mark Tyndall, Mel Krajden
BACKGROUND: Population-level monitoring of hepatitis C virus (HCV) infected people across the cascade of care identifies gaps in access and engagement in care and treatment. We characterized a population-level cascade of care for HCV in British Columbia (BC), Canada and identified factors associated with leakage at each stage. METHODS: The BC Hepatitis Testers Cohort (BC-HTC) includes 1.5million individuals tested for HCV, HIV, reported cases of hepatitis B, and active tuberculosis in BC from 1990 to 2013 linked to medical visits, hospitalizations, cancers, prescription drugs and mortality data...
October 2016: EBioMedicine
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