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https://www.readbyqxmd.com/read/27885757/role-of-primary-t-cell-immunodeficiency-and-hepatitis-b-coinfection-on-spontaneous-clearance-of-hepatitis-c-the-bc-hepatitis-testers-cohort
#1
N Islam, M Krajden, M Gilbert, P Gustafson, A Yu, M Kuo, M Chong, M Alvarez, J Wong, M W Tyndall, N Z Janjua
T-cell host immune response against hepatitis C virus (HCV) has been suggested to play an important role in determining HCV infection outcome. However, data from human studies are not available. This study examined the effect of primary T-cell deficiency along with other factors on the spontaneous clearance of HCV in a large population-based cohort in British Columbia, Canada. The BC Hepatitis Testers Cohort includes all individuals tested for HCV in BC in 1990-2013 linked with data on their medical visits, hospitalizations and prescription drugs...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27870801/relationship-between-uveitis-different-types-of-viral-hepatitis-and-liver-cirrhosis-a-12-year-nationwide-population-based-cohort-study
#2
Peng-Tai Tien, Chun-Ju Lin, Yi-Yu Tsai, Huan-Sheng Chen, De-Kuang Hwang, Chih-Hsin Muo, Jane-Ming Lin, Wen-Lu Chen
PURPOSE: This study investigates whether patients with viral hepatitis and cirrhosis are at risk of uveitis in the years following hepatitis. METHODS: We used data from Taiwan National Health Insurance system. The cases were patients newly diagnosed with viral hepatitis from 2000 to 2011. The end point of interest was a diagnosis of uveitis. A chi-square test was used for the difference of demographic characteristics between viral hepatitis and comparison. The risk of uveitis in hepatitis was stratified using Cox proportional hazard regression...
December 2016: Retina
https://www.readbyqxmd.com/read/27867437/sero-prevalence-and-correlates-of-hepatitis-b-and-c-co-infection-among-hiv-infected-individuals-in-two-regional-hospitals-in-cameroon
#3
Henry Namme Luma, Servais Albert Fiacre Bagnaka Eloumou, Domin Sone Majunda Ekaney, Fernando Kemta Lekpa, Olivier Donfack-Sontsa, Bertrand Hugo Mbatchou Ngahane, Yacouba Njankouo Mapoure
BACKGROUND: Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive. OBJECTIVE: We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals. METHODS: A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres...
2016: Open AIDS Journal
https://www.readbyqxmd.com/read/27858889/correlates-of-infection-and-molecular-characterization-of-blood-borne-hiv-hcv-and-hbv-infections-in-hiv-1-infected-inmates-in-italy-an-observational-cross-sectional-study
#4
Nunzia Sanarico, Stefania D'Amato, Roberto Bruni, Claudia Rovetto, Emanuela Salvi, Patrizia Di Zeo, Paola Chionne, Elisabetta Madonna, Giulio Pisani, Angela Costantino, Michele Equestre, Maria E Tosti, Alessandra Cenci, Maria T Maggiorella, Leonardo Sernicola, Emanuele Pontali, Alfredo Pansera, Rocco Quattrocchi, Sergio Carbonara, Fabio Signorile, Lorenzo Antonio Surace, Guido Federzoni, Elisa Garlassi, Giulio Starnini, Roberto Monarca, Sergio Babudieri, Maria Rapicetta, Maria G Pompa, Anna Caraglia, Barbara Ensoli, Anna R Ciccaglione, Stefano Buttò
Coinfection of blood-borne hepatitis B and hepatitis C viruses (HBV and HCV, respectively) in human immunodeficiency virus type 1 (HIV-1)-positive individuals frequently occurs in inmate population and peculiar viral strains and patterns of virological markers may be observed.Plasma from 69 HIV-1-positive inmates was obtained from 7 clinical centers connected with correctional centers in different towns in Italy. HIV, HBV, and HCV markers were tested by commercial assays. Virus genotyping was carried out by sequencing the protease and reverse transcriptase-encoding region (PR-RT region) for HIV and a region encompassing the NS5B gene for HCV and subsequent phylogenetic analysis...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27755152/hepatocellular-carcinoma-in-patients-with-hiv
#5
Imane El Dika, James J Harding, Ghassan K Abou-Alfa
PURPOSE OF REVIEW: Hepatocellular carcinoma (HCC) is becoming an important cause of mortality in patients with HIV, attributed to coinfection with hepatitis C virus, hepatitis B virus, and the longer survival advantage these patients are achieving after introducing the highly active antiretroviral therapy (HAART) regimens. RECENT FINDINGS: In addition to hepatitis infection, immunosuppression secondary to HIV infection, direct impact of the virus on liver parenchyma, and the use of hepatotoxic antiretroviral drugs, all contribute to HCC pathogenesis...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27750294/chronic-hepatitis-b-and-c-virus-infection-and-risk-for-non-hodgkin-lymphoma-in-hiv-infected-patients-a-cohort-study
#6
Qing Wang, Andrea De Luca, Colette Smith, Robert Zangerle, Helen Sambatakou, Fabrice Bonnet, Colette Smit, Philipp Schommers, Alicia Thornton, Juan Berenguer, Lars Peters, Vincenzo Spagnuolo, Adriana Ammassari, Andrea Antinori, Eugenia Quiros Roldan, Cristina Mussini, Jose M Miro, Deborah Konopnicki, Jan Fehr, Maria A Campbell, Monique Termote, Heiner C Bucher
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)...
October 18, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27746337/hepatitis-delta-associated-mortality-in-hiv-hbv-coinfected-patients
#7
Charles Béguelin, Darius Moradpour, Roland Sahli, Franziska Suter-Riniker, Alexander Lüthi, Matthias Cavassini, Huldrych F Günthard, Manuel Battegay, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Dominique L Braun, Hansjakob Furrer, Andri Rauch, Gilles Wandeler
BACKGROUND & AIMS: Hepatitis delta virus (HDV) infection accelerates the progression of hepatitis B virus (HBV)-related liver disease. We assessed the epidemiological characteristics of HDV infection in the nationwide Swiss HIV Cohort Study and evaluated its impact on clinical outcomes. METHODS: All HIV-infected patients with a positive hepatitis B surface antigen test were considered and tested for anti-HDV antibodies. HDV amplification and sequencing were performed in anti-HDV-positive patients...
October 14, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27596150/the-population-level-cascade-of-care-for-hepatitis-c-in-british-columbia-canada-the-bc-hepatitis-testers-cohort-bc-htc
#8
Naveed Z Janjua, Margot Kuo, Amanda Yu, Maria Alvarez, Stanley Wong, Darrel Cook, Jason Wong, Jason Grebely, Zahid A Butt, Hasina Samji, Alnoor Ramji, Mark Tyndall, Mel Krajden
BACKGROUND: Population-level monitoring of hepatitis C virus (HCV) infected people across the cascade of care identifies gaps in access and engagement in care and treatment. We characterized a population-level cascade of care for HCV in British Columbia (BC), Canada and identified factors associated with leakage at each stage. METHODS: The BC Hepatitis Testers Cohort (BC-HTC) includes 1.5million individuals tested for HCV, HIV, reported cases of hepatitis B, and active tuberculosis in BC from 1990 to 2013 linked to medical visits, hospitalizations, cancers, prescription drugs and mortality data...
August 25, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27588826/a-dual-role-for-mannan-binding-lectin-associated-serine-protease-2-masp-2-in-hiv-infection
#9
Angelica Beate Winter Boldt, Márcia Holsbach Beltrame, Sandra Jeremias Catarino, Caroline Grisbach Meissner, Regina Tizzot, Iara Jose Messias-Reason
BACKGROUND: Mannan-binding lectin (MBL) - associated serine protease 2 (MASP-2) co-activates the lectin pathway of complement in response to several viral infections. The quality of this response partly depends on MASP2 gene polymorphisms, which modulate MASP-2 function and serum levels. In this study we investigated a possible role of MASP2 polymorphisms, MASP-2 serum levels and MBL-mediated complement activation in the susceptibility to HIV/AIDS and HBV/HCV coinfection. METHODS: A total of 178 HIV patients, 89 (50%) coinfected with HBV/HCV, 51...
October 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27585801/hepatocellular-carcinoma-and-viral-hepatitis-in-new-york-city
#10
Miranda S Moore, Elena Ivanina, Katherine Bornschlegel, Baozhen Qiao, Maria J Schymura, Fabienne Laraque
BACKGROUND:  Hepatocellular carcinoma (HCC) incidence and mortality are increasing in the United States. Viral hepatitis infection is a primary risk factor for HCC. This study describes the relationship between viral hepatitis and HCC in New York City (NYC). METHODS:  Viral hepatitis cases reported to the NYC Department of Health from 1999-2012 were matched to HCC cases diagnosed from 2001-2012 and reported to the New York State Cancer Registry. HCC cases were stratified by presence or absence of viral hepatitis...
September 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27583932/maternal-hcv-infection-is-associated-with-intrauterine-fetal-growth-disturbance-a-meta-analysis-of-observational-studies
#11
Qi-Tao Huang, Li-Lin Hang, Mei Zhong, Yun-Fei Gao, Man-Ling Luo, Yan-Hong Yu
Since the evidence regarding the association between maternal hepatitis C virus (HCV) infection and impaired intrauterine fetal growth had not been conclusive, the aim of the present study was to evaluate the risk of maternal HCV infection in association with intrauterine fetal growth restriction (IUGR) and/or low birth weight infants (LBW). We performed an extensive literature search of PubMed, MEDLINE, and EMBASE through December 1, 2015. The odds ratios (ORs) of HCV infection and IUGR/LBW were calculated and reported with 95% confidence intervals (95% CIs)...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27569777/trends-in-hepatocellular-carcinoma-among-people-with-hbv-or-hcv-notification-in-australia-2000-2014
#12
Reem Waziry, Jason Grebely, Janaki Amin, Maryam Alavi, Behzad Hajarizadeh, Jacob George, Gail V Matthews, Matthew Law, Gregory J Dore
BACKGROUND & AIMS: This study evaluates trends in hepatocellular carcinoma (HCC) among people with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in New South Wales (NSW), Australia between 2000 and 2014. METHODS: Data on HBV and HCV notifications between January 1993 and December 2012 were linked to the NSW Admitted Patients Data Collection database between July 2000 and June 2014 and NSW Registry of Births Deaths and Marriages. The burden, crude and age-standardised incidence of HCC based on first hospitalization were calculated...
August 26, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27564643/t-cell-distribution-in-relation-to-hiv-hbv-hcv-coinfections-and-intravenous-drug-use
#13
Eveli Kallas, Kristi Huik, Silver Türk, Merit Pauskar, Ene-Ly Jõgeda, Marina Šunina, Tõnis Karki, Don Des Jarlais, Anneli Uusküla, Radko Avi, Irja Lutsar
Intravenous drug use (IDU) is one of the most important transmission routes for blood borne viruses, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). These infections alter the subset distributions of T cells; however, knowledge of such effects during HIV, HBV, and or HCV coinfection is limited. Therefore, we aimed to evaluate any associations between T cell distribution and the presence of HIV, HBV, and HCV coinfections among persons who inject drugs (PWID)...
October 2016: Viral Immunology
https://www.readbyqxmd.com/read/27490638/prevalence-and-predictors-of-low-muscle-mass-in-hiv-viral-hepatitis-coinfection
#14
Charitha Gowda, Todd T Brown, Charlene Compher, Kimberly A Forde, Jay Kostman, Pamela A Shaw, Phyllis C Tien, Vincent Lo Re
OBJECTIVE: Low muscle mass is associated with reduced survival in HIV, possibly mediated by systemic inflammation. Viral hepatitis coinfection can induce additional inflammation and hepatic dysfunction that may exacerbate low muscle mass. We determined the prevalence of and risk factors for low muscle mass in HIV/viral hepatitis coinfection. DESIGN AND METHODS: A cross-sectional study of participants in the Multicenter AIDS Cohort Study and Women's Interagency HIV Study with anthropometry performed after 1 January 2000...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27478915/elevated-alanine-aminotransferase-levels-in-hiv-infected-persons-without-hepatitis-b-or-c-virus-coinfection
#15
Saad Alghamdi, Abdullah Alrbiaan, Ali Alaraj, Ahmad Alhuraiji, Mohammad Alghamdi, Abdulrahman Alrajhi
BACKGROUND: Mortality related to human immunodeficiency (HIV) has improved with the use of antiretroviral therapy; however, liver disease-related mortality remains a major concern for the HIV population. Elevation of alanine aminotransferase (ALT) has been noted in HIV-infected persons even without viral hepatitis infection. OBJECTIVE: The objective of this study was to determine the incidence and prevalence of chronic alanine ALT elevation among patients infected with HIV who are negative for hepatitis B or C infection...
July 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27436414/twin-epidemics-of-new-and-prevalent-hepatitis-c-infections-in-canada-bc-hepatitis-testers-cohort
#16
Naveed Zafar Janjua, Amanda Yu, Margot Kuo, Maria Alvarez, Darrel Cook, Jason Wong, Mark W Tyndall, Mel Krajden
BACKGROUND: We characterized the twin epidemics of new and prevalent hepatitis C virus (HCV) infections in British Columbia, Canada to inform prevention, care and treatment programs. METHODS: The BC Hepatitis Testers Cohort (BC-HTC) includes individuals tested for HCV, HIV or reported as a case of HBV, HCV, HIV or active TB between 1990-2013 linked with data on their medical visits, hospitalizations, cancers, prescription drugs and mortality. Prevalent infection was defined as being anti-HCV positive at first test...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27367295/ledipasvir-and-sofosbuvir-for-hcv-infection-in-patients-coinfected-with-hbv
#17
Edward J Gane, Robert H Hyland, Di An, Evguenia S Svarovskaia, Diana Brainard, John G McHutchison
BACKGROUND: Currently there are no all-oral treatment regimens for HCV in patients coinfected with HBV. In this pilot study, we evaluated whether ledipasvir and sofosbuvir therapy can suppress HCV infection in patients coinfected with HBV. METHODS: Patients with HBV and genotype-1 HCV received 90 mg ledipasvir and 400 mg sofosbuvir daily for 12 weeks. The efficacy end point was sustained virological response (HCV RNA <15 IU/ml) 12 weeks after the end of treatment...
July 1, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27366331/pcr-based-molecular-diagnosis-of-hepatitis-virus-hbv-and-hdv-in-hcv-infected-patients-and-their-biochemical-study
#18
Muhammad Nasir Riaz, Muhammad Faheem, Muhammad Ayaz Anwar, Ummar Raheel, Yasmeen Badshah, Hashaam Akhtar, Kosar Tamanna, Muhammad Tahir, Najam Us Sahar Sadaf Zaidi, Ishtiaq Qadri
Seroprevalence of HCV indicates that HCV is found in more than 10% of HBV- or HDV-infected patients worldwide leading to liver disease. Here we show HBV and HDV coinfection association with HCV infected Pakistani patients, study of disease severity, and possible interpretation of associated risk factors in coinfected patients. A total of 730 liver diseased patients were included, out of which 501 were found positive for HCV infection via PCR. 5.1% of patients were coinfected with HBV while 1% were coinfected with HBV and HDV both...
2016: Journal of Pathogens
https://www.readbyqxmd.com/read/27329484/a-case-of-acute-hepatitis-b-in-a-chronic-hepatitis-c-patient-after-daclatasvir-and-asunaprevir-combination-therapy-hepatitis-b-virus-reactivation-or-acute-self-limited-hepatitis
#19
Kazuhiko Hayashi, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Daisaku Nishimura, Hidemi Goto, Yoshiki Hirooka
Reactivation of hepatitis B virus (HBV) in HBV surface antigen (HBsAg)-positive patients treated with cytotoxic chemotherapy is well known. HBV reactivation in patients with HBV and hepatitis C virus (HCV) coinfection caused by direct-acting antiviral (DAA) therapy has also recently been reported. We report a case of acute hepatitis B in a patient with HCV infection after DAA therapy. An 83-year-old woman was referred for chronic hepatitis C. She was infected with HCV genotype 1b and negative for HBsAg at baseline...
August 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27272189/complete-hepatitis-b-virus-prophylaxis-withdrawal-in-hepatitis-b-surface-antigen-positive-liver-transplant-recipients-after-longterm-minimal-immunosuppression
#20
Ilaria Lenci, Leonardo Baiocchi, Laura Tariciotti, Daniele Di Paolo, Martina Milana, Francesco Santopaolo, Tommaso Maria Manzia, Luca Toti, Valentina Svicher, Giuseppe Tisone, Carlo Federico Perno, Mario Angelico
Tailored approaches have been attempted to prevent hepatitis B virus (HBV) reinfection in antibodies against hepatitis B surface antigen (HBsAg)-positive liver transplantation (LT) recipients in order to minimize the use of hepatitis B immune globulin (HBIG) and nucleoside analogues (NAs). We report the results of complete HBV prophylaxis withdrawal after a follow-up of at least 6 years in LT recipients with undetectable serum HBV DNA and intrahepatic total HBV DNA and covalently closed circular DNA at LT. We included 30 HBsAg positive, hepatitis B e antigen-negative recipients, 6 with hepatitis C virus and 7 with hepatitis D virus coinfection, who had received HBIG plus NA for at least 5 years after LT...
September 2016: Liver Transplantation
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