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optical neuritis diagnostic

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https://www.readbyqxmd.com/read/29222573/incidence-and-causes-of-overdiagnosis-of-optic-neuritis
#1
Leanne Stunkel, Nathan H Kung, Bradley Wilson, Collin M McClelland, Gregory P Van Stavern
Importance: Diagnostic error is an important source of medical error. Overdiagnosis of optic neuritis may prompt unnecessary and costly diagnostic tests, procedures, and treatments. Objective: To assess the incidence of and characterize factors contributing to overdiagnosis of acute optic neuritis. Design, Setting, and Participants: In this retrospective clinic-based cross-sectional study of new patient encounters, 122 patients referred for acute optic neuritis at a university-based Midwestern neuro-ophthalmology clinic between January 2014 and October 2016 were studied...
December 7, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29195504/blinded-by-zika-a-missed-hiv-diagnosis-that-resulted-in-optic-neuropathy-and-blindness-a-case-report
#2
Tiffany Hirschel, Heimo Steffen, Victor Pecoul, Alexandra Calmy
BACKGROUND: Typical symptoms of an acute human immunodeficiency virus (HIV) infections like fever and rash are not specific and can be caused by a multitude of other pathogens, such as Zika or rickettsiosis. Up to 30% of primary HIV infection do not present with the typical flu-like symptoms and thus represent a diagnostic challenge. In this report, we describe a rare case of optic neuropathy as the initial presentation of primary HIV infection, which resulted in irreversible blindness...
December 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29166458/mog-igg-associated-optic-neuritis-is-not-multiple-sclerosis
#3
Bruna Klein da Costa, Giordani Rodrigues Dos Passos, Jefferson Becker, Douglas Kazutoshi Sato
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. METHODS AND RESULTS: Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29141797/diagnosis-and-management-of-neuromyelitis-optica-spectrum-disorder-nmosd-in-iran-a-consensus-guideline-and-recommendations
#4
REVIEW
Mohammad Ali Sahraian, Abdorreza Naser Moghadasi, Amir Reza Azimi, Nasrin Asgari, Fahimeh H Akhoundi, Roya Abolfazli, Shekoofeh Alaie, Fereshteh Ashtari, Hormoz Ayromlou, Seyed Mohammad Baghbanian, Nahid Beladi Moghadam, Farzad Fatehi, Mohsen Foroughipour, Hamidreza Ghalyanchi Langroodi, Nastaran Majdinasab, Alireza Nickseresht, Abbas Nourian, Vahid Shaygannejad, Hamid Reza Torabi
Neuromyelitis Optica Spectrum Disorder (NMOSD) is a relapsing neuro inflammatory disease of the central nervous system that typically presents with optic neuritis or myelitis and may cause severe disability. The diagnostic criteria have been updated and several immunosuppressive agents have been demonstrated to prevent acute exacerbations. As the disease rarely develops in a progressive course, management of acute attacks and proper prevention of exacerbations may change the long term out-come and prevent future disability...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29119196/-optical-coherence-tomography-in-neuromyelitis-optica-spectrum-disorders
#5
REVIEW
F C Oertel, H Zimmermann, A U Brandt, F Paul
Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory conditions of the central nervous system (CNS). In 55% of the cases of NMOSD optic neuritis (ON) is the most frequent first manifestation and can cause severe damage to the afferent visual system and the retina with resultant severe visual impairment. In recent years, investigations of the retina as part of the CNS by optical coherence tomography (OCT) has been shown to be a valid and efficient method for diagnostics and evaluation of the disease course in NMOSD...
November 8, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29103426/the-spectrum-of-inflammatory-acquired-demyelinating-syndromes-in-children
#6
Rinze Neuteboom, Colin Wilbur, Danielle Van Pelt, Moses Rodriguez, Ann Yeh
Acquired demyelinating syndromes in childhood comprise a spectrum of monophasic and recurrent inflammatory conditions of the central nervous system. Examples of monophasic conditions include, clinically isolated syndromes such as optic neuritis and transverse myelitis, as well as acute disseminated encephalomyelitis, whereas recurrent disorders include entities such as multiple sclerosis and neuromyelitis optica spectrum disorder. Knowledge about these disorders has expanded due to rigorously evaluated diagnostic criteria, magnetic resonance imaging features, outcomes, and serum biomarkers in these disorders...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29090843/changes-in-oxygen-saturation-and-the-retinal-nerve-fibre-layer-in-patients-with-optic-neuritis-a-pilot-study
#7
Tereza Svrčinová, Jan Mareš, Oldřich Chrapek, Irena Šínová, Martina Rybariková, Pavel Otruba, Petr Kaňovský, Martin Šín
PURPOSE: Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: Thirty-two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29055475/neuromyelitis-optica-spectrum-disorder-mimicking-multiple-sclerosis
#8
Lucas C van Rooij, Mike P Wattjes, Brigit A de Jong, Bob W van Oosten
BACKGROUND: MS is a demyelinating CNS disease and has distinct clinical and radiological features. Neuromyelitis optica spectrum disorder (NMOSD) is an antibody related auto-immune disease known for invalidating episodes of myelitis and optic neuritis. OBJECTIVE: Reporting the case of a 29-year old woman with a disease course typical for relapsing remitting MS with consistent radiological and spinal fluid findings, who developed longitudinally extensive transverse myelitis (LETM) with positive aquaporin 4 antibodies, fulfilling the diagnostic criteria for NMOSD...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055474/gender-differences-among-chinese-patients-with-neuromyelitis-optica-spectrum-disorders
#9
Hui Sun, Xuan Sun, Jie Li, Yunyun Huo, Lei Wu, Dehui Huang, Shengyuan Yu, Weiping Wu
BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune, inflammatory demyelinating diseases of the central nervous system, which have established variations in prevalence across different ethnicities and genders. The objective of this study was to investigate differences in clinical features among men and women with NMOSD, according to the 2015 diagnostic criteria. METHODS: A total of 97 patients with NMOSD were recruited from inpatient neurology clinics in this retrospective study...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#10
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29021839/diffusion-tensor-imaging-for-multilevel-assessment-of-the-visual-pathway-possibilities-for-personalized-outcome-prediction-in-autoimmune-disorders-of-the-central-nervous-system
#11
REVIEW
Joseph Kuchling, Alexander U Brandt, Friedemann Paul, Michael Scheel
The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28991690/neuromyelitis-optica-spectrum-disorders-with-antibodies-to-myelin-oligodendrocyte-glycoprotein-or-aquaporin-4-clinical-and-paraclinical-characteristics-in-algerian-patients
#12
Melissa Bouzar, Smail Daoudi, Samira Hattab, Amel A Bouzar, Kumaran Deiva, Brigitte Wildemann, Markus Reindl, Sven Jarius
BACKGROUND: Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder of the central nervous system. NMO and its abortive forms are referred to as NMO spectrum disorders (NMOSD). NMOSD are mostly associated with antibodies to aquaporin-4 (AQP4-IgG). However, recent studies have demonstrated antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) in a subset of patients. Data on NMOSD in North Africa are sparse. OBJECTIVE: To describe the frequency of MOG-IgG and AQP4-IgG among patients with optic neuritis (ON) and/or myelitis in Algeria as well as the clinical and paraclinical features associated with these antibodies...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28980518/a-population-based-prospective-study-of-optic-neuritis
#13
K Soelberg, S Jarius, Hpb Skejoe, H Engberg, J J Mehlsen, A C Nilsson, J S Madsen, M Reindl, B Wildemann, J Grauslund, K O Kyvik, T J Smith, S T Lillevang, F Paul, B G Weinshenker, N Asgari
BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28941527/pediatric-optic-neuritis
#14
Melinda Y Chang, Stacy L Pineles
Optic neuritis is rare in children in comparison to adults, but accounts for approximately 25% of pediatric acute demyelinating syndromes. Features of pediatric optic neuritis that differ from adults include a higher rate of bilaterality, poor visual acuity on presentation, and papillitis. Diagnostic work-up includes brain magnetic resonance imaging, lumbar puncture, and blood tests to exclude infectious and inflammatory disorders. Pediatric optic neuritis may occur following infection or vaccination, or in association with a systemic demyelinating process such as acute disseminated encephalomyelitis, neuromyelitis optica, or multiple sclerosis...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28887838/diagnostic-accuracy-of-optical-coherence-tomography-inter-eye-percentage-difference-for-optic-neuritis-in-multiple-sclerosis
#15
D Coric, L J Balk, B M J Uitdehaag, A Petzold
BACKGROUND AND PURPOSE: Multiple sclerosis-associated optic neuritis (MSON) causes atrophy of the inner retinal layers, which can be quantified by optical coherence tomography. It has been suggested that the inter-eye percentage difference (IEPD) of atrophy may be of diagnostic value in MSON. METHODS: This was a prospective, cross-sectional study in patients with multiple sclerosis and healthy controls (HCs). Spectral-domain optical coherence tomography of both eyes was performed, followed by automated retinal layer segmentation of the peri-papillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (mGCIPL)...
September 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28879451/prognostic-factors-and-disease-course-in-aquaporin-4-antibody-positive-chinese-patients-with-acute-optic-neuritis
#16
Hao Kang, Tingjun Chen, Hongyang Li, Quangang Xu, Shanshan Cao, Shihui Wei
The objective is to assess the frequency of AQP4-Ab in Chinese patients with optic neuritis (ON) and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients. The presence of aquaporin-4 (AQP4) antibodies in human AQP4-transfected cells was determined by indirect immunofluorescence, and the diagnostic and prognostic relevance of AQP4 antibodies in 215 Chinese patients with optic neuritis was evaluated. The patients were enrolled from the Chinese People's Liberation Army General Hospital (PLAGH) and followed up to 1-228 months...
October 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28814415/optical-coherence-tomography-angiography-enhances-the-detection-of-optic-nerve-damage-in-multiple-sclerosis
#17
Rebecca I Spain, Liang Liu, Xinbo Zhang, Yali Jia, Ou Tan, Dennis Bourdette, David Huang
BACKGROUND: Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS). OBJECTIVE: To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS. METHODS: Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic disc...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28806345/pediatric-optic-neuritis-what-is-new
#18
REVIEW
Mark Borchert, Grant T Liu, Stacy Pineles, Amy T Waldman
Few diseases blur the margins between their childhood and adult-onset varieties as much as optic neuritis. This report will review our state of knowledge of pediatric optic neuritis, as well as its relationship to the latest consensus definitions of neuroinflammatory disease. Current diagnostic and treatment options will be explored, as well as our potential to uncover an understanding of pediatric optic neuritis through systematic prospective studies. The risk of evolving multiple sclerosis is probably less than in adults, but pediatric optic neuritis is more likely to be an initial manifestation of acute disseminated encephalomyelitis...
September 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28733756/glial-and-neuronal-antibodies-in-patients-with-idiopathic-intracranial-hypertension
#19
Güneş Altıokka-Uzun, Ece Erdağ, Betül Baykan, John Tzartos, Duygu Gezen-Ak, Bedia Samancı, Erdinç Dursun, Paraskevi Zisimopoulou, Katerina Karagiorgou, Christos Stergiou, Erdi Şahin, Esme Ekizoğlu, Murat Kürtüncü, Erdem Tüzün
Headache and visual disturbances are the main presenting symptoms of idiopathic intracranial hypertension (IIH) characterized by increased intracranial pressure (ICP) with an unknown cause. We aimed to investigate the antibodies against optic neuritis-associated glial antigens, aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) and uncharacterized neuronal membrane antigens in IIH patients. Consecutive patients diagnosed according to Friedman revised diagnostic criteria and control subjects were included after their consent...
July 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28647756/role-of-coronal-high-resolution-diffusion-weighted-imaging-in-acute-optic-neuritis-a-comparison-with-axial-orientation
#20
Ping Lu, Yan Sha, Hailin Wan, Feng Wang, Guohong Tian
PURPOSE: Through a comparison with the axial orientation, we aimed to evaluate the role of coronal high-resolution diffusion-weighted imaging (DWI) in acute optic neuritis based on diagnostic accuracy and the reproducibility of apparent diffusion coefficient (ADC) measurements. METHODS: Orbital DWI, using readout-segmented, parallel imaging, and 2D navigator-based reacquisition (RESOLVE-DWI), was performed on 49 patients with acute vision loss. The coronal (thickness = 3 mm) and axial (thickness = 2 mm) diffusion images were evaluated by two neuroradiologists retrospectively...
August 2017: Neuroradiology
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