Marie-Luise Herrlein, Paul Schmanke, Fabian Elgner, Catarina Sabino, Sami Akhras, Daniela Bender, Mirco Glitscher, Denna Tabari, Catharina Scholl, Julia Stingl, Eberhard Hildt
Zika virus (ZIKV) is a flavivirus that is mainly transmitted by Aedes mosquitos and normally causes mild symptoms. During the outbreak in the Americas in 2015, it was associated with more severe implications, like microcephaly in new-borns and the Gullain-Barré syndrome. The lack of specific vaccines and cures strengthen the need for a deeper understanding of the virus life cycle and virus-host interactions. The restriction factor tetherin (THN) is an interferon-inducible cellular protein with broad antiviral properties...
December 22, 2021: Journal of Virology