keyword
MENU ▼
Read by QxMD icon Read
search

Epigenetics immune response

keyword
https://www.readbyqxmd.com/read/29780254/are-ovarian-cancer-stem-cells-the-target-for-innovative-immunotherapy
#1
REVIEW
Liang Wang, Tianmin Xu, Manhua Cui
Cancer stem cells (CSCs), a subpopulation of cancer cells with the ability of self-renewal and differentiation, are believed to be responsible for tumor generation, progression, metastasis, and relapse. Ovarian cancer, the most malignant gynecological cancer, has consistent pathology behavior with CSC model, which suggests that therapies based on ovarian cancer stem cells (OCSCs) can gain a more successful prognosis. Much evidence has proved that epigenetic mechanism played an important role in tumor formation and sustainment...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29777212/regulation-of-macrophage-immunometabolism-in-atherosclerosis
#2
REVIEW
Graeme J Koelwyn, Emma M Corr, Ebru Erbay, Kathryn J Moore
After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as discrete epigenetic changes, that can dictate both ongoing and future inflammatory responses. In atherosclerosis, in which macrophages play central roles in the initiation, growth, and ultimately rupture of arterial plaques, altered metabolism is a key feature that dictates macrophage function and subsequent disease progression. This Review explores how factors central to the plaque microenvironment (for example, altered cholesterol metabolism, oxidative stress, hypoxia, apoptotic and necrotic cells, and hyperglycemia) shape the metabolic rewiring of macrophages in atherosclerosis as well as how these metabolic shifts in turn alter macrophage immune-effector and tissue-reparative functions...
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29774218/new-insights-of-helicobacter-pylori-host-pathogen-interactions-the-triangle-of-virulence-factors-epigenetic-modifications-and-non-coding-rnas
#3
REVIEW
Farzam Vaziri, Samira Tarashi, Abolfazl Fateh, Seyed Davar Siadat
Helicobacter pylori ( H. pylori ) is a model organism for understanding host-pathogen interactions and infection-mediated carcinogenesis. Gastric cancer and H. pylori colonization indicates the strong correlation. The progression and exacerbation of H. pylori infection are influenced by some factors of pathogen and host. Several virulence factors involved in the proper adherence and attenuation of immune defense to contribute the risk of emerging gastric cancer, therefore analysis of them is very important...
May 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29774056/epigenetic-regulation-of-inflammation-in-stroke
#4
REVIEW
Gavin Yong-Quan Ng, Lim Yun-An, Christopher G Sobey, Thameem Dheen, David Yang-Wei Fann, Thiruma V Arumugam
Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammatory events occur during stroke, arising in part due to the body's immune response to brain injury. Neuroinflammation contributes significantly to neuronal cell death and the development of functional impairment and death in stroke patients...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29771197/emerging-insights-into-wnt-%C3%AE-catenin-signaling-in-head-and-neck-cancer
#5
K A Alamoud, M A Kukuruzinska
Head and neck cancer presents primarily as head and neck squamous cell carcinoma (HNSCC), a debilitating malignancy fraught with high morbidity, poor survival rates, and limited treatment options. Mounting evidence indicates that the Wnt/β-catenin signaling pathway plays important roles in the pathobiology of HNSCC. Wnt/β-catenin signaling affects multiple cellular processes that endow cancer cells with the ability to maintain and expand immature stem-like phenotypes, proliferate, extend survival, and acquire aggressive characteristics by adopting mesenchymal traits...
June 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29771158/global-methylation-profiles-in-buccal-cells-of-long-term-smokers-and-moist-snuff-consumers
#6
Walter J Jessen, Michael F Borgerding, G L Prasad
PURPOSE: Alternations in gene methylation and other epigenetic changes regulate normal development as well as drive disease progression. The aim of this study is to investigate global methylation changes in the buccal cells of smokers and smokeless tobacco users. MATERIALS AND METHODS: Generally healthy adult male subjects were recruited into Smoker (SMK), Moist Snuff Consumer (MSC) and Non-Tobacco Consumer (NTC) cohorts (40 subjects/cohort) (ClinicalTrials.gov Identifier: NCT01923402)...
May 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29760811/global-dna-methylation-changes-spanning-puberty-are-near-predicted-estrogen-responsive-genes-and-enriched-for-genes-involved-in-endocrine-and-immune-processes
#7
Emma E Thompson, Jessie Nicodemus-Johnson, Kyung Won Kim, James E Gern, Daniel J Jackson, Robert F Lemanske, Carole Ober
Background: The changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic and environmental factors have been associated with the onset or delay of puberty, and recent evidence has suggested a role for epigenetic changes in the initiation of puberty as well. Objective: To identify global DNA methylation changes that arise across the window of puberty in girls and boys...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29760044/nk-cells-mediate-synergistic-antitumor-effects-of-combined-inhibition-of-hdac6-and-bet-in-a-sclc-preclinical-model
#8
Yan Liu, Yuyang Li, Shengwu Liu, Dennis O Adeegbe, Camilla L Christensen, Max M Quinn, Ruben Dries, Shiwei Han, Kevin Buczkowski, Xiaoen Wang, Ting Chen, Peng Gao, Hua Zhang, Fei Li, Peter S Hammerman, James E Bradner, Steven N Quayle, Kwok-Kin Wong
Small cell lung cancer (SCLC) has the highest malignancy among all lung cancers, exhibiting aggressive growth and early metastasis to distant sites. For 30 years, treatment options for SCLC have been limited to chemotherapy, warranting the need for more effective treatments. Frequent inactivation of TP53 and RB1 as well as histone dysmodifications in SCLC suggest that transcriptional and epigenetic regulations play a major role in SCLC disease evolution. Here we performed a synthetic lethal screen using the BET inhibitor JQ1 and an shRNA library targeting 550 epigenetic genes in treatment-refractory SCLC xenograft models and identified HDAC6 as a synthetic lethal target in combination with JQ1...
May 14, 2018: Cancer Research
https://www.readbyqxmd.com/read/29757566/-traffic-related-air-pollution-and-allergic-rhinitis
#9
REVIEW
Guo Liu, Shi Xi Liu
Exposure to traffic-related air pollutants(TRAP)has been implicated in airway allergic diseases.Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of TRAP on allergic rhinitis(AR)and the biology underlying this impact.These studies have found that oxidative stress induced by TRAP could affect the axis of epithelial cell-dendritic cell-T cell towards a T-helper 2 immune response,which is the major mechanism between TRAP and AR.Further,epigenetics and microRNA might be involved in this process...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29754176/micrornas-regulatory-messengers-inside-and-outside-cancer-cells
#10
Simone Anfossi, Xiao Fu, Rahul Nagvekar, George A Calin
MicroRNAs (miRNAs) are a class of short non-coding RNAs (ncRNAs) with typical sequence lengths of 19-25 nucleotides and extraordinary abilities to regulate gene expression. Because miRNAs regulate multiple important biological functions of the cell (proliferation, migration, invasion, apoptosis, differentiation, and drug resistance), their expression is highly controlled. Genetic and epigenetic alterations frequently found in cancer cells can cause aberrant expression of miRNAs and, consequently, of their target genes...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29740313/epigenome-wide-association-study-of-soluble-tumor-necrosis-factor-receptor-2-levels-in-the-framingham-heart-study
#11
Michael M Mendelson, Roby Johannes, Chunyu Liu, Tianxiao Huan, Chen Yao, Xiao Miao, Joanne M Murabito, Josée Dupuis, Daniel Levy, Emelia J Benjamin, Honghuang Lin
Background: Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF receptor II (sTNFR2) can modify the inflammatory response of immune cells and is predictive of cardiovascular disease risk. We hypothesize that sTNFR2 is associated with epigenetic modifications of circulating leukocytes, which may relate to the pathophysiology underlying atherogenic risk. Methods: We conducted an epigenome-wide association study of sTNFR2 levels in the Framingham Heart Study Offspring cohort (examination 8; 2005-2008)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29735547/epigenetic-regulation-of-cxcl12-plays-a-critical-role-in-mediating-tumor-progression-and-the-immune-response-in-osteosarcoma
#12
Binghao Li, Zhan Wang, Hao Wu, Mingfeng Xue, Peng Lin, Shengdong Wang, Nong Lin, Xin Huang, Weibo Pan, Meng Liu, Xiaobo Yan, Hao Qu, Lingling Sun, Hengyuan Li, Yan Wu, Wangsiyuan Teng, Zenan Wang, Xingzhi Zhou, Huabiao Chen, Mark C Poznansky, Zhaoming Ye
The mechanism by which osteosarcomas metastasize is elusive, and challenges remain regarding its treatment with modalities including immunotherapy. CXCL12 is deeply involved in the process of tumor metastasis and T-cell homing, which is driven by a chemokine gradient, but healthy bones are supposed to preferentially express CXCL12. Here we show for the first time that osteosarcomas epigenetically downregulate CXCL12 expression via DNA methyltransferase 1 (DNMT1) and consequently acquire the ability to metastasize and impair cytotoxic T-cell homing to the tumor site...
May 7, 2018: Cancer Research
https://www.readbyqxmd.com/read/29734016/clinical-significance-of-pten-deletion-mutation-and-loss-of-pten-expression-in-de-novo-diffuse-large-b-cell-lymphoma
#13
Xiaoxiao Wang, Xin Cao, Ruifang Sun, Charlene Tang, Alexandar Tzankov, Jun Zhang, Ganiraju C Manyam, Min Xiao, Yi Miao, Kausar Jabbar, Xiaohong Tan, Yuyang Pang, Carlo Visco, Yan Xie, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L Richards, Eric D Hsi, William W L Choi, J Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J M Ferreri, Michael B Møller, Ben M Parsons, Jane N Winter, Miguel A Piris, Shaoying Li, Roberto N Miranda, L Jeffrey Medeiros, Yong Li, Zijun Y Xu-Monette, Ken H Young
PTEN loss has been associated with poorer prognosis in many solid tumors. However, such investigation in lymphomas is limited. In this study, PTEN cytoplasmic and nuclear expression, PTEN gene deletion, and PTEN mutations were evaluated in two independent cohorts of diffuse large B-cell lymphoma (DLBCL). Cytoplasmic PTEN expression was found in approximately 67% of total 747 DLBCL cases, more frequently in the activated B-cell-like subtype. Nuclear PTEN expression was less frequent and at lower levels, which significantly correlated with higher PTEN mRNA expression...
May 3, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29732386/naturally-occurring-canine-invasive-urothelial-carcinoma-a-model-for-emerging-therapies
#14
REVIEW
Breann C Sommer, Deepika Dhawan, Timothy L Ratliff, Deborah W Knapp
The development of targeted therapies and the resurgence of immunotherapy offer enormous potential to dramatically improve the outlook for patients with invasive urothelial carcinoma (InvUC). Optimization of these therapies, however, is crucial as only a minority of patients achieve dramatic remission, and toxicities are common. With the complexities of the therapies, and the growing list of possible drug combinations to test, highly relevant animal models are needed to assess and select the most promising approaches to carry forward into human trials...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29729581/immune-prophets-of-lung-cancer-the-prognostic-and-predictive-landscape-of-cellular-and-molecular-immune-markers
#15
REVIEW
Ivana Catacchio, Anna Scattone, Nicola Silvestris, Anita Mangia
Lung cancer is the leading cause of cancer deaths throughout the world. The majority of patients are diagnosed with locally advanced or metastatic disease when surgery, the best curative option, is no longer feasible. Thus, the prognosis of lung cancer remains poor and heterogeneous and new biomarkers are needed. As the immune system plays a pivotal role in cancer, the study of tumor microenvironment, with regard to the immune component, may provide valuable information for a better comprehension of the pathogenesis and progression of the disease...
May 2, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29718165/bisphenol-a-and-phthalates-modulate-peritoneal-macrophage-function-in-female-mice-involving-symd2-h3k36-dimethylation
#16
Quanxi Li, Catherine R Lawrence, Romana A Nowak, Jodi A Flaws, Milan K Bagchi, Indrani C Bagchi
Ample evidence suggests that environmental and occupational exposure to bisphenol A (BPA) and phthalate, two chemicals widely used in the plastics industry, disturbs homeostasis of innate immunity and causes inflammatory diseases. However, the underlying molecular mechanisms of these toxicants in the regulation of macrophage inflammatory functions remain poorly understood. In this study, we addressed the effect of chronic exposure to BPA or phthalate at levels relevant to human exposure, either in vitro or in vivo, on the inflammatory reprograming of peritoneal macrophages...
May 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29717661/cd4-t-cell-activation-during-the-newborn-period-barriers-against-and-pathways-toward-th1-immunity
#17
Luke S Uebelhoer, Christina L Lancioni
During the period of transition from intrauterine to extrauterine life, the neonatal immune system must learn to rapidly identify pathogens while balancing pro-inflammatory, antimicrobial responses with immune regulation that allows for resolution of inflammation and limits responses to commensal organisms and benign environmental antigens. However, the naive immune system of neonates is presented with several barriers that limit robust proinflammatory immune responses. Specifically, epigenetic modifications to neonatal naive CD4+ T cells, heightened neonatal regulatory T cell frequency and function, and limitations in the co-stimulatory potential of neonatal antigen presenting cells restrict development of CD4+ T cells with a T-helper 1 type functional profile...
2018: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/29710412/post-translational-modifications-in-priming-the-plant-immune-system-ripe-for-exploitation
#18
REVIEW
Daniel de Vega, Adrian C Newton, Ari Sadanandom
Microbes constantly challenge plants, and some can successfully infect their host and cause disease. Basal immunity against plant pathogens in many cases is not enough for survival and leads to disease and, ultimately, a premature death of the host plant. However, the plant immune system can be temporarily and even trans-generationally primed; this 'primed state' leads to changes in the plant involving transcriptional, post-translational, metabolic, physiological and epigenetic reprogramming, which enables fine-tuning defence mechanisms for a rapid and/or more robust response after abiotic and/or biotic stress...
April 30, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29709672/of-pleiotropy-and-trajectories-does-the-tgfb-pathway-link-childhood-asthma-and-copd
#19
Avery DeVries, Donata Vercelli
The study of developmental trajectories is where epigenetics truly shines. The "epi" in epi-genetics captures the fact that although epigenetic processes also preside over the maintenance and termination of gene expression, the unfolding and remodeling of chromatin architecture are especially critical to prepare genes for regulated transcription. These properties imply being on a path, a trajectory to events that will occur later on thanks to epigenetic programming. Thus, epigenetics is about timed and timely events...
April 27, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29703886/plasma-cell-differentiation-is-controlled-by-multiple-cell-division-coupled-epigenetic-programs
#20
Christopher D Scharer, Benjamin G Barwick, Muyao Guo, Alexander P R Bally, Jeremy M Boss
The genomic loci associated with B cell differentiation that are subject to transcriptional and epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the development of humoral immune responses. Here, using an in vivo T cell independent B cell differentiation model, we define a cellular division-dependent cis-regulatory element road map using ATAC-seq. Chromatin accessibility changes correlate with gene expression and reveal the reprogramming of transcriptional networks and the genes they regulate at specific cell divisions...
April 27, 2018: Nature Communications
keyword
keyword
100232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"