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https://www.readbyqxmd.com/read/29454750/a-newly-discovered-antifibrotic-pathway-regulated-by-two-fatty-acid-receptors-gpr40-and-gpr84
#1
Lyne Gagnon, Martin Leduc, Jean-Francois Thibodeau, Ming-Zhi Zhang, Brigitte Grouix, Francois Sarra-Bournet, William Gagnon, Kathy Hince, Mikaël Tremblay, Lilianne Geerts, Christopher R J Kennedy, Richard L Hébert, Alex Gutsol, Chet E Holterman, Eldjonai Kamto, Liette Gervais, Jugurtha Ouboudinar, Jonathan Richard, Alexandra Felton, Alexandre Laverdure, Jean-Christophe Simard, Sylvie Létourneau, Marie-Pier Cloutier, Francois A Leblond, Shaun D Abbott, Christopher Penney, Jean-Simon Duceppe, Boulos Zacharie, Jocelyn Dupuis, Angelino Calderone, Quang Trinh Nguyen, Raymond C Harris, Pierre Laurin
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein-coupled receptors with free fatty acid ligands and are associated with metabolic and inflammatory disorders. Although GPR40 and GPR84 are involved in diverse physiological processes, no evidence has demonstrated the relevance of GPR40 and GPR84 in fibrosis pathways. Using PBI-4050 (3-pentylbenzeneacetic acid sodium salt), a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively, we uncovered an antifibrotic pathway involving these receptors...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29453318/integration-of-distinct-shca-signaling-complexes-promotes-breast-tumor-growth-and-tyrosine-kinase-inhibitor-resistance
#2
Jacqueline R Ha, Ryuhjin Ahn, Harvey W Smith, Valerie Sabourin, Steven Hėbert, Eduardo Cepeda Cañedo, Young Kyuen Im, Claudia Kleinman, William J Muller, Josie Ursini-Siegel
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. Receptor tyrosine kinases (RTKs), such as ErbB2, engage the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29448145/concurrent-nicotine-and-tobacco-product-use-among-homeless-smokers-and-associations-with-cigarette-dependence-and-other-factors-related-to-quitting
#3
Julie Neisler, Lorraine R Reitzel, Lorra Garey, Darla E Kenzdor, Emily T Hébert, Maya Vijayaraghavan, Michael S Businelle
BACKGROUND: Cigarette smoking rates among homeless adults are exceptionally high, contributing to health disparities experienced by this disadvantaged population. Concurrent nicotine and tobacco product use have been shown to result in greater health problems than cigarette smoking alone, and little is known about the rates, motives, and perceived impacts of concurrent use in this group. The purpose of this study is to explore concurrent use rates and constructs of interest among homeless adult daily smokers and to examine differences between concurrent users and non-concurrent users on cigarette dependence, perceived risk of smoking, readiness to quit, and the receipt of recent cessation intervention...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29447712/n%C3%A2-355-fondements-physiologiques-de-la-douleur-pendant-le-travail-et-l-accouchement-approche-de-soulagement-bas%C3%A3-e-sur-les-donn%C3%A3-es-probantes
#4
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
No abstract text is available yet for this article.
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#5
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29446488/spatial-trends-in-a-biomagnifying-contaminant-application-of-amino-acid-compound-specific-stable-nitrogen-isotope-analysis-to-the-interpretation-of-bird-mercury-levels
#6
Svetlana Dolgova, Brian N Popp, Kevin Courtoreille, Rick H M Espie, Bruce Maclean, Mark McMaster, Jason R Straka, Gerald R Tetreault, Steve Wilkie, Craig E Hebert
Levels of biomagnifying contaminants are greatest in high trophic level biota, e.g. predatory birds such as gulls. Gull eggs have been used to assess contaminant spatial patterns and sources but such assessments must consider how organism trophic position may influence spatial inferences. Stable nitrogen isotopes (δ 15 N) in bulk tissue are routinely used in this context. However, bulk δ 15 N values are only useful if spatial differences in baseline δ 15 N values are considered. Amino acid-compound specific stable nitrogen isotope analysis (AA-CSIA) can generate estimates of baseline and trophic position δ 15 N from the same sample...
February 15, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29446003/development-of-a-ready-to-use-tool-that-includes-preventability-for-the-assessment-of-adverse-drug-events-in-oncology
#7
Guillaume Hébert, Florence Netzer, Sylvain Landry Kouakou, François Lemare, Etienne Minvielle
Background Adverse drug events (ADEs) occur frequently in oncology and justify continuous assessment and monitoring. There are several methods for detecting them, but the trigger tool method seems the most appropriate. Although a generic tool exists, its use for ADEs in oncology has not been convincing. The development of a focused version is therefore necessary. Objective To provide an oncology-focused trigger tool that evaluates the prevalence, harm, and preventability in a standardised method for pragmatic use in ADE surveillance...
February 14, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29444120/computer-tomography-based-body-surface-area-evaluation-for-drug-dosage-quantitative-radiology-versus-anthropomorphic-evaluation
#8
Antoine Iannessi, Hubert Beaumont, Christophe Hebert, Claire Dittlot, Marie Noëlle Falewee
OBJECTIVE: The measure of body surface area (BSA) is a standard for planning optimal dosing in oncology. This index is derived from a model having questionable performances. In this study, we proposed measurement of BSA from whole body CT images (iBSA). We tested the reliability of iBSA assessments and simulated the impact of our approach on patient chemotherapy dosage planning. METHODS: We first evaluated accuracy and precision of iBSA in measuring 14 phantom and 11 CT test-retest images...
2018: PloS One
https://www.readbyqxmd.com/read/29440393/granule-stored-muc5b-mucins-are-packed-by-the-non-covalent-formation-of-n-terminal-head-to-head-tetramers
#9
Sergio Trillo-Muyo, Harriet E Nilsson, Christian V Recktenwald, Anna Ermund, Caroline Ridley, Lauren N Meiss, Andrea Bahr, Nikolai Klymiuk, Jeffrey J Wine, Philip J Koeck, David J Thornton, Hans Hebert, Gunnar C Hansson
Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers, which are further packed into larger assemblies because of low pH and high Ca2+ in the secretory granule of the mucin-producing cell. We purified the recombinant MUC5B N-terminal covalent dimer and used single-particle electron microscopy to study its structure under intracellular conditions. We found that at intragranular pH, the dimeric MUC5B organized into head-to-head noncovalent tetramers where the von Willebrand D1-D2 domains hooked into each other...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29439509/dietary-inflammatory-index-and-cardiovascular-risk-and-mortality-a-meta-analysis
#10
REVIEW
Nitin Shivappa, Justyna Godos, James R Hébert, Michael D Wirth, Gabriele Piuri, Attilio F Speciani, Giuseppe Grosso
Diet and chronic inflammation have been suggested to be risk factors in the development of cardiovascular disease (CVD) and related mortality. The possible link between the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII ® ) and CVD has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from 14 studies were eligible, of which two were case-control, eleven were cohort, and one was cross-sectional...
February 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29435202/podocyte-derived-microparticles-promote-proximal-tubule-fibrotic-signaling-via-p38-mapk-and-cd36
#11
Mercedes N Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E Holterman, Rania Nasrallah, Richard L Hébert, Christopher R J Kennedy, Dylan Burger
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100-1000 nm vesicles shed from injured cells that are implicated in intercellular signalling. Our lab recently observed the formation of MPs from podocytes and their release into urine of animal models of type 1 and 2 diabetes and in humans with type 1 diabetes. The purpose of the present study was to examine the role of podocyte MPs in tubular epithelial cell fibrotic responses...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29433936/microrna-219-reduces-viral-load-and-pathologic-changes-in-theiler-s-virus-induced-demyelinating-disease
#12
Ana Lis Moyano, Jeffrey Steplowski, Haibo Wang, Kyung-No Son, Diana I Rapolti, Jeffrey Marshall, Vince Elackattu, Michael S Marshall, Amy K Hebert, Cory R Reiter, Viviana Ulloa, Katarzyna C Pituch, Maria I Givogri, Q Richard Lu, Howard L Lipton, Ernesto R Bongarzone
Analysis of microRNA (miR) expression in the central nervous system white matter of SJL mice infected with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV) revealed a significant reduction of miR-219, a critical regulator of myelin assembly and repair. Restoration of miR-219 expression by intranasal administration of a synthetic miR-219 mimic before disease onset ameliorates clinical disease, reduces neurogliosis, and partially recovers motor and sensorimotor function by negatively regulating proinflammatory cytokines and virus RNA replication...
January 17, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29431698/mef2c-phosphorylation-is-required-for-chemotherapy-resistance-in-acute-myeloid-leukemia
#13
Fiona C Brown, Eric Still, Richard P Koche, Christina Y Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B Ficarro, Peter Romanienko, Willie Mark, Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée, Josée Hébert, Andrei V Krivstov, Ari Melnick, Elisabeth M Paietta, Martin S Tallman, Anthony Letai, Guy Sauvageau, Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A Armstrong, Alex Kentsis
In acute myeloid leukemia, chemotherapy resistance remains prevalent and poorly understood. Using functional proteomics of patient AML specimens, we identified MEF2C S222 phosphorylation as a specific marker of primary chemoresistance. We found that Mef2c S222A/S222A knock-in mutant mice engineered to block MEF2C phosphorylation exhibited normal hematopoiesis, but were resistant to leukemogenesis induced by MLL-AF9. MEF2C phosphorylation was required for leukemia stem cell maintenance, and induced by MARK kinases in cells...
February 5, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29430610/mentoring-training-and-scholarly-productivity-experiences-of-cancer-related-health-disparities-research-trainees-do-outcomes-differ-for-underrepresented-scientists
#14
Tisha M Felder, Kathryn L Braun, Lisa Wigfall, Maria Sevoyan, Shraddha Vyas, Samira Khan, Heather M Brandt, Charles Rogers, Sora Tanjasiri, Cheryl A Armstead, James R Hébert
The study aims to explore variation in scholarly productivity outcomes by underrepresented status among a diverse sample of researchers in a community-engaged training program. We identified 141 trainees from a web-based survey of researchers in the National Cancer Institute-funded, Community Networks Program Centers (CNPCs) (2011-2016). We conducted a series of multiple logistic regression models to estimate the effect of National Institutes of Health (NIH)-defined underrepresented status on four, self-reported, scholarly productivity outcomes in the previous 5 years: number of publications (first-authored and total) and funded grants (NIH and any agency)...
February 12, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29428880/multiple-traumas-and-resilience-among-street-children-in-haiti-psychopathology-of-survival
#15
Jude Mary Cénat, Daniel Derivois, Martine Hébert, Laetitia Mélissande Amédée, Amira Karray
In Haiti, as in several developing countries, the phenomenon of street children has become a major public health issue. These children are often victims of traumas and adverse life events. This article aimed to investigate traumas experienced by street children and their coping and resilience strategies used to deal with adversities in a logic of survival, relying on a mixed method approach. A group of 176 street children, aged 7-18 (n = 21 girls), recruited in Port-au-Prince, completed measures assessing PTSD, social support and resilience...
February 8, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29427526/nup98-bptf-gene-fusion-identified-in-primary-refractory-acute-megakaryoblastic-leukemia-of-infancy
#16
Mathieu Roussy, Mélanie Bilodeau, Loubna Jouan, Pauline Tibout, Louise Laramée, Emmanuelle Lemyre, Sophie Cardin, Camille Sauvageau, Françoise Couture, Aurélien Choblet, Natalie Patey, Patrick Gendron, Michel Duval, Pierre Teira, Josée Hébert, Brian T Wilhelm, John K Choi, Tanja A Gruber, Henrique Bittencourt, Sonia Cellot
The advent of large scale genomic sequencing technologies significantly improved the molecular classification of acute megakaryoblastic leukaemia (AMKL). AMKL represents a subset (∼10%) of high fatality pediatric acute myeloid leukemia (AML). Recurrent and mutually exclusive chimeric gene fusions associated with pediatric AMKL are found in 60-70% of cases and include RBM15-MKL1, CBFA2T3-GLIS2, NUP98-KDM5A and MLL rearrangements. In addition, another 4% of AMKL harbor NUP98 rearrangements (NUP98r), with yet undetermined fusion partners...
February 10, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29426751/the-dietary-inflammatory-index-and-current-wheeze-among-children-and-adults-in-the-united-states
#17
Yueh-Ying Han, Erick Forno, Nitin Shivappa, Michael D Wirth, James R Hébert, Juan C Celedón
BACKGROUND: A proinflammatory diet may increase allergic airway inflammation by affecting innate and adaptive immune responses. OBJECTIVE: In this study, we examine the relation between the diet's inflammatory potential, measured by the Dietary Inflammatory Index (DII), and current asthma, current wheeze, and lung function in U.S. children and adults. METHODS: We analyzed data from 8,175 children (aged 6-17 years) and 22,294 adults (aged 18-79 years) who participated in the 2007-2012 National Health and Nutrition Examination Survey...
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29414858/lower-dietary-inflammatory-index-scores-are-associated-with-lower-glycemic-index-scores-among-college-students
#18
Yeonsoo Kim, Jie Chen, Michael D Wirth, Nitin Shivappa, James R Hebert
The association between the Dietary Inflammatory Index (DII®), the glycemic index (GI), and the glycemic load (GL) is not known, although it is known that carbohydrates are pro-inflammatory. We aimed to measure the association between the DII and both GI and GL among college students. In this cross-sectional study, 110 college students completed a 3-day food diary, which was used to calculate the DII, the GI, the GL, and the healthy eating index (HEI)-2010. Least square means and 95% confidence intervals of the GI, the GL, and the HEI-2010 were presented per DII tertile using generalized linear mixed models...
February 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29408485/integrative-structural-investigation-on-the-architecture-of-human-importin4_histone-h3-h4_asf1a-complex-and-its-histone-h3-tail-binding
#19
Jungmin Yoon, Seung Joong Kim, Sojin An, Saehyun Cho, Alexander Leitner, Taeyang Jung, Ruedi Aebersold, Hans Hebert, Uhn-Soo Cho, Ji-Joon Song
Importin4 transports histone H3/H4 in complex with Asf1a to the nucleus for chromatin assembly. Importin4 recognizes the nuclear localization sequence located at the N-terminal tail of histones. Here, we analyzed the structures and interactions of human Importin4, histones and Asf1a by cross-linking mass spectrometry (XL-MS), X-ray crystallography, negative-stain electron microscopy, small-angle X-ray scattering and integrative modeling. The XL-MS data showed that the C-terminal region of Importin4 was extensively crosslinked with the histone H3 tail...
January 30, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29407687/cognitive-deficits-in-individuals-with-methamphetamine-use-disorder-a-meta-analysis
#20
REVIEW
Stéphane Potvin, Julie Pelletier, Stéphanie Grot, Catherine Hébert, Alastair Barr, Tania Lecomte
BACKGROUND: Methamphetamine has long been considered as a neurotoxic substance causing cognitive deficits. Recently, however, the magnitude and the clinical significance of the cognitive effects associated with methamphetamine use disorder (MUD) have been debated. To help clarify this controversy, we performed a meta-analysis of the cognitive deficits associated with MUD. METHODS: A literature search yielded 44 studies that assessed cognitive dysfunction in 1592 subjects with MUD and 1820 healthy controls...
January 30, 2018: Addictive Behaviors
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