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https://www.readbyqxmd.com/read/28548969/transcriptome-profiling-in-preadipocytes-identifies-long-noncoding-rnas-as-sam68-targets
#1
Naomi Li, Steven Hébert, Jingwen Song, Claudia L Kleinman, Stéphane Richard
The KH-type RNA binding protein Sam68 is required for adipogenesis. We have previously shown that Sam68-deficient mice have a lean phenotype and are protected against dietary-induced obesity due to defects in mTOR and S6K1 alternative splicing. Herein we profiled the transcriptome of Sam68 wild type and deficient 3T3-L1 mouse preadipocytes. We identified 652 protein-coding genes and 9 ncRNAs that were significantly altered with the loss of Sam68. As expected, downregulated genes were significantly associated with GO terms linked to cell migration, motility, and fat cell differentiation, while upregulated genes were mostly associated with GO terms linked to neurogenesis...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544794/inflammatory-potential-of-diet-weight-gain-and-incidence-of-overweight-obesity-the-sun-cohort
#2
Raúl Ramallal, Estefanía Toledo, J Alfredo Martínez, Nitin Shivappa, James R Hébert, Miguel A Martínez-González, Miguel Ruiz-Canela
OBJECTIVE: This study prospectively assessed the association of the inflammatory potential of a diet using the dietary inflammatory index (DII) with average yearly weight changes and incident overweight/obesity. METHODS: Seven thousand and twenty-seven university graduates with body mass index <25 from the Seguimiento Universidad de Navarra (SUN) cohort were followed up during a median of 8.1 years. The DII, a validated tool based on scientific evidence to appraise the relationship between dietary parameters and inflammatory biomarkers, was used...
June 2017: Obesity
https://www.readbyqxmd.com/read/28542873/a-map-of-the-phosphoproteomic-alterations-that-occur-after-a-bout-of-maximal-intensity-contractions
#3
Gregory K Potts, Rachel M McNally, Rocky Blanco, Jae-Sung You, Alexander S Hebert, Michael S Westphall, Joshua J Coon, Troy A Hornberger
The maintenance of skeletal muscle mass is essential for health and quality of life. It is well recognized that maximal-intensity contractions, such as those which occur during resistance exercise, promote an increase in muscle mass. Yet, the molecules that sense the mechanical information and convert it into the signalling events (e.g. phosphorylation) that drive the increase in muscle mass remain undefined. Here we describe a phosphoproteomics workflow to examine the effects of electrically evoked maximal-intensity contractions (MIC) on protein phosphorylation in mouse skeletal muscle...
May 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28537268/global-mapping-of-carm1-substrates-defines-enzyme-specificity-and-substrate-recognition
#4
Evgenia Shishkova, Hao Zeng, Fabao Liu, Nicholas W Kwiecien, Alexander S Hebert, Joshua J Coon, Wei Xu
Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent role in normal physiology and disease. PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for cancer therapy; however, few CARM1 substrates are known, and its mechanism of substrate recognition is poorly understood. Here we employed a quantitative mass spectrometry approach to globally profile CARM1 substrates in breast cancer cell lines...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534479/efficient-protein-production-inspired-by-how-spiders-make-silk
#5
Nina Kronqvist, Médoune Sarr, Anton Lindqvist, Kerstin Nordling, Martins Otikovs, Luca Venturi, Barbara Pioselli, Pasi Purhonen, Michael Landreh, Henrik Biverstål, Zigmantas Toleikis, Lisa Sjöberg, Carol V Robinson, Nicola Pelizzi, Hans Jörnvall, Hans Hebert, Kristaps Jaudzems, Tore Curstedt, Anna Rising, Jan Johansson
Membrane proteins are targets of most available pharmaceuticals, but they are difficult to produce recombinantly, like many other aggregation-prone proteins. Spiders can produce silk proteins at huge concentrations by sequestering their aggregation-prone regions in micellar structures, where the very soluble N-terminal domain (NT) forms the shell. We hypothesize that fusion to NT could similarly solubilize non-spidroin proteins, and design a charge-reversed mutant (NT*) that is pH insensitive, stabilized and hypersoluble compared to wild-type NT...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28531379/the-association-between-an-inflammatory-diet-and-global-cognitive-function-and-incident-dementia-in-older-women-the-women-s-health-initiative-memory-study
#6
Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, Linda G Snetselaar, Oleg Zaslavsky, Stephen R Rapp
INTRODUCTION: The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. METHODS: Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28528388/fertility-sparing-for-young-patients-with-gynecologic-cancer-how-mri-can-guide-patient-selection-prior-to-conservative-management
#7
REVIEW
Sinead H McEvoy, Stephanie Nougaret, Nadeem R Abu-Rustum, Hebert Alberto Vargas, Elizabeth A Sadowski, Christine O Menias, Fuki Shitano, Shinya Fujii, Ramon E Sosa, Joanna G Escalon, Evis Sala, Yulia Lakhman
Historically, cancer treatment has emphasized measures for the "cure" regardless of the long-term consequences. Advances in cancer detection and treatment have resulted in improved outcomes bringing to the fore various quality of life considerations including future fertility. For many young cancer patients, fertility preservation is now an integral component of clinical decision-making and treatment design. Optimal fertility-sparing options for young patients with gynecologic cancer are influenced by patient age, primary cancer, treatment regimens, and patient preferences...
May 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28509823/progression-of-fatty-muscle-degeneration-in-atraumatic-rotator-cuff-tears
#8
Jonah Hebert-Davies, Sharlene A Teefey, Karen Steger-May, Aaron M Chamberlain, William Middleton, Kathryn Robinson, Ken Yamaguchi, Jay D Keener
BACKGROUND: The purpose of this prospective study was to examine the progression of fatty muscle degeneration over time in asymptomatic shoulders with degenerative rotator cuff tears. METHODS: Subjects with an asymptomatic rotator cuff tear in 1 shoulder and pain due to rotator cuff disease in the contralateral shoulder were enrolled in a prospective cohort. Subjects were followed annually with shoulder ultrasonography, which evaluated tear size, location, and fatty muscle degeneration...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28503716/dietary-inflammatory-index-and-non-hodgkin-lymphoma-risk-in-an-italian-case-control-study
#9
Nitin Shivappa, James R Hébert, Martina Taborelli, Maurizio Montella, Massimo Libra, Antonella Zucchetto, Anna Crispo, Maria Grimaldi, Carlo La Vecchia, Diego Serraino, Jerry Polesel
BACKGROUND: While dietary factors have been shown to play an important etiologic role in non-Hodgkin lymphoma (NHL), little is known about the association between inflammatory properties of diet and NHL risk. METHODS: We explored the association between the dietary inflammatory index (DII) and NHL risk in a multicenter Italian case-control study conducted between 1999 and 2014. Cases were 536 subjects with incident, histologically confirmed NHL from three areas in Italy...
May 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28500906/feasibility-and-reliability-of-a-mobile-tool-to-evaluate-exposure-to-tobacco-product-marketing-and-messages-using-ecological-momentary-assessment
#10
Emily T Hébert, Elizabeth A Vandewater, Michael S Businelle, Melissa B Harrell, Steven H Kelder, Cheryl L Perry
INTRODUCTION: Existing measures of tobacco marketing and messaging exposure are limited, relying on recall, recognition, or proxy measures. This study aimed to determine the feasibility and reliability of a mobile application for the measurement of tobacco and e-cigarette marketing and message exposure using ecological momentary assessment (EMA). METHODS: Young adults from Austin, TX (n=181, ages 18-29) were instructed to use a mobile application to record all sightings of marketing or social media related to tobacco (including e-cigarettes) in real-time for 28days (Event EMAs)...
May 3, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28494774/expanding-conceptualizations-of-harm-reduction-results-from-a-qualitative-community-based-participatory-research-study-with-people-who-inject-drugs
#11
L M Boucher, Z Marshall, A Martin, K Larose-Hébert, J V Flynn, C Lalonde, D Pineau, J Bigelow, T Rose, R Chase, R Boyd, M Tyndall, C Kendall
BACKGROUND: The perspectives of people who use drugs are critical in understanding why people choose to reduce harm in relation to drug use, what practices are considered or preferred in conceptualizations of harm reduction, and which environmental factors interfere with or support the use of harm reduction strategies. This study explores how people who inject drugs (PWID) think about harm reduction and considers the critical imperative of equity in health and social services delivery for this community...
May 12, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28493362/associations-of-prenatal-and-early-life-dietary-inflammatory-potential-with-childhood-adiposity-and-cardiometabolic-risk-in-project-viva
#12
S Sen, S L Rifas-Shiman, N Shivappa, M D Wirth, J R Hebert, D R Gold, M W Gillman, E Oken
BACKGROUND: Limited information exists regarding the association between early-life diet and cardiometabolic risk. OBJECTIVES: Examine associations of dietary inflammatory index (DII) in pregnancy and early childhood (3-5 years) with adiposity, blood pressure and metabolic markers in mid-childhood (6-10 years). METHODS: Among 992 mother-child pairs from Project Viva, a pre-birth cohort, we examined associations of DII scores with outcomes using multivariable linear regression adjusted for child age and sex and maternal age, BMI, education, parity, smoking, race and income...
May 10, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28488928/do-subjective-assessments-of-running-patterns-reflect-objective-parameters
#13
Thibault Lussiana, Cyrille Gindre, Laurent Mourot, Kim Hébert-Losier
Running patterns are often categorized into subgroups according to common features before data analysis and interpretation. The Volodalen(®) method is a simple field-based tool used to classify runners into aerial or terrestrial using a 5-item subjective rating scale. We aimed to validate the Volodalen(®) method by quantifying the relationship between its subjective scores and 3D biomechanical measures. Fifty-four runners ran 30 s on a treadmill at 10, 12, 14, 16, and 18 km h(-1) while their kinematics were assessed subjectively using the Volodalen(®) method and objectively using 3D motion capture...
May 10, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28487804/exploring-a-third-confirmed-case-of-hemoperitoneum-following-open-inguinal-hernia-repair-caused-by-sampson-artery-hemorrhage
#14
Jordan Hebert, Manoj Jagtiani, Alexander Hsu, David Schmelzer, Fred Wolodiger
Hemoperitoneum is a rare complication of open inguinal hernia repair. This is the third reported case of this complication attributed to the same bleeding source: Sampson's artery. Sampson's artery courses along the round ligament of the uterus in the inguinal canal of females, originating from the arcade formed between the uterine and ovarian arteries. Usually obliterated in postembryonic development, this artery can persist in some adult female patients. Disruption of Sampson's artery can lead to hemoperitoneum following ligation of the uterine round ligament during open inguinal hernia repair in females...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28487182/mitochondria-bioenergetic-and-cognitive-functions-the-cannabinoid-link
#15
Giacomo Mancini, Tamas L Horvath
Despite the well-known role of chronic mitochondrial dysfunction in the pathophysiology of the brain, the impact of acute impairment of mitochondrial activity by cannabinoids on higher brain functions is unknown. In a recent paper in Nature, Hebert-Chatelain et al. elegantly uncovered the essential role that bioenergetic processes have in the regulation of higher brain functions, such as learning and memory.
June 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28487151/dietary-inflammatory-potential-is-linked-to-cardiovascular-disease-risk-burden-in-the-us-adult-population
#16
Stefanos Tyrovolas, Ai Koyanagi, Georgios A Kotsakis, Demosthenes Panagiotakos, Nitin Shivappa, Michael D Wirth, James R Hébert, Josep Maria Haro
BACKGROUND: Dietary guidelines are a key tool in the public health quiver. Single nutrients have been linked to cardiovascular diseases, but existing metrics do not capture the overall effect of diet on inflammatory diseases. The aim of this study was to examine the association between dietary inflammatory potential and cardiovascular diseases risk factors (CVD-RFs) in a nationally-representative sample of non-institutionalized US adults using data from the continuous National Health and Nutrition Examination Survey (NHANES) (2007-2012)...
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28486621/changes-in-the-inflammatory-potential-of-diet-over-time-and-risk-of-colorectal-cancer-in-postmenopausal-women
#17
Fred K Tabung, Susan E Steck, Yunsheng Ma, Angela D Liese, Jiajia Zhang, Dorothy S Lane, Gloria Y F Ho, Lifang Hou, Linda Snetselaar, Judith K Ockene, James R Hebert
We examined the associations between changes in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal women recruited from 1993-1998 into the Women's Health Initiative. Food frequency questionnaire data were used to compute patterns of change in dietary inflammatory index (DII) scores and cumulative average DII scores over 3 years. Cox regression models were used to estimate hazard ratios for CRC risk. After a median 16.2 years follow-up, 1,038 CRC cases were diagnosed...
May 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28483978/fgf-dependent-context-driven-role-for-frs-adapters-in-the-early-telencephalon
#18
Sayan Nandi, Grigoriy Gutin, Christopher A Blackwood, Nachiket G Kamatkar, Kyung W Lee, Gordon Fishell, Fen Wang, Mitchell Goldfarb, Jean M Hébert
FGF signaling, an important component of intercellular communication, is required in many tissues throughout development to promote diverse cellular processes. Whether FGF receptors (FGFRs) accomplish such varied tasks in part by activating different intracellular transducers in different contexts remains unclear. Here we use the developing mouse telencephalon as an example to study the role of the FRS adapters, FRS2 and FRS3, in mediating the functions of FGFRs. Using tissue-specific and germline mutants, we examine the requirement of Frs genes in two FGFR-dependent processes...
May 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28481985/dietary-inflammatory-index-and-acute-myocardial-infarction-in-a-large-italian-case-control-study
#19
Nitin Shivappa, Alessandra Tavani, James R Hébert, Valentina Rosato, Carlo La Vecchia
Diet and inflammation have been implicated to play a role in the incidence of acute myocardial infarction (AMI). In this Italian case-control study conducted between 1995 and 2003, we explored the association between the dietary inflammatory index (DII TM ) and AMI. Cases were 760 patients, below age 79 years, with a first episode of nonfatal AMI and controls were 682 patients admitted to hospital for acute conditions unrelated to diet. The DII was computed based on dietary intake assessed using a reproducible and validated 78-item food frequency questionnaire...
May 6, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28481633/the-best-of-both-worlds-avatar-assisted-therapy-offers-the-benefits-of-therapist-assisted-and-internet-based-interventions
#20
Darla E Kendzor, Emily T Hébert
No abstract text is available yet for this article.
May 8, 2017: American Journal of Drug and Alcohol Abuse
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