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https://www.readbyqxmd.com/read/28437475/the-school-malaise-trap-program-coupling-educational-outreach-with-scientific-discovery
#1
Dirk Steinke, Vanessa Breton, Emily Berzitis, Paul D N Hebert
The School Malaise Trap Program (SMTP) provides a technologically sophisticated and scientifically relevant educational experience that exposes students to the diversity of life, enhancing their understanding of biodiversity while promoting environmental stewardship. Since 2013, the SMTP has allowed 15,000 students at 350 primary and secondary schools to explore insect diversity in Canadian schoolyards. Students at each school collected hundreds of insects for an analysis of DNA sequence variation that enabled their rapid identification to a species...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28436231/the-utility-of-real-time-quantitative-polymerase-chain-reaction-genotype-detection-in-the-diagnosis-of-urinary-tract-infections-in-children
#2
Jon R Felt, Chelsey Yurkovich, Danielle M Garshott, Deepak Kamat, Ahmad Farooqi, Andrew M Fribley, Michael U Callaghan, Katherine Hebert
Urinary tract infections (UTIs) are the most common serious bacterial infection in children with significant morbidity with delayed diagnosis. Polymerase chain reaction (PCR) is very accurate in detecting bacteria and widely available, but has never been evaluated to detect UTIs in children. To assess the utility of PCR as a rapid diagnostic tool, we conducted a prospective cohort study of 193 urine samples from children younger than 36 months undergoing evaluation for UTI in the emergency department over a 10-month period...
April 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28434623/does-unilateral-insular-resection-disturb-personality-a-study-with-epileptic-patients
#3
Benjamin Hébert-Seropian, Olivier Boucher, Carole Sénéchal, Isabelle Rouleau, Alain Bouthillier, Franco Lepore, Dang Khoa Nguyen
The insula is now regarded as a potential site of epileptogenesis in drug-resistant epilepsy, and the advent of microsurgical techniques has allowed insular cortectomy to become a treatment of choice when the insular cortex is involved in the seizure focus. However, considering the evidence of an insular role in socio-emotional processing, it remains unknown whether these cortical resections disturb personality and social behavior as experienced in daily life. We examined such changes in a group of patients (n=19) who underwent epilepsy surgery involving partial or complete resection of the insula, and compared them to a group of patients who underwent standard temporal lobe epilepsy (TLE) surgery (n=19) as a lesion-control group...
April 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28424183/biomarker-calibrated-nutrient-intake-and-healthy-diet-index-associations-with-mortality-risks-among-older-and-frail-women-from-the-women-s-health-initiative
#4
Oleg Zaslavsky, Shira Zelber-Sagi, James R Hebert, Susan E Steck, Nitin Shivappa, Fred K Tabung, Michael D Wirth, Yunqi Bu, James M Shikany, Tonya Orchard, Robert B Wallace, Linda Snetselaar, Lesley F Tinker
Background: Although studies to date have confirmed the association between nutrition and frailty, the impact of dietary intake and dietary patterns on survivorship in those with frailty is yet to be examined in a well-powered cohort with validated frailty status. Moreover, previous studies were limited by measurement error from dietary self-reports.Objective: We derived biomarker-calibrated dietary energy and protein intakes to address dietary self-report error. Using these data, we then evaluated the association of mortality in older women with frailty and dietary intake and healthy diet indexes, such as the alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII)...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28420273/role-of-inflammation-in-the-association-between-the-western-dietary-pattern-and-metabolic-syndrome-among-lebanese-adults
#5
Farah Naja, Nitin Shivappa, Lara Nasreddine, Samer Kharroubi, Leila Itani, Nahla Hwalla, Abla Mehio Sibai, James R Hebert
The aim of this study was to investigate whether inflammation mediates the previously observed direct association between the western dietary pattern (WDP) and metabolic syndrome (MetS) among Lebanese adults. Sociodemographic, lifestyle, dietary pattern scores, anthropometric and biochemical data of 331 adults were used in this study. Inflammation indicators considered were: serum C-reactive protein (CRP) and the dietary inflammatory index (DII). The scores of the WDP were significantly associated with DII (r = ...
April 19, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28417881/understanding-gpcr-signaling-in-the-brain-the-path-to-cns-drug-discovery
#6
EDITORIAL
David Chatenet, Terence E Hébert
No abstract text is available yet for this article.
February 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28413429/falling-under-the-umbrella-cells-a-single-institutional-experience-and-literature-review-of-urothelial-carcinoma-presenting-as-a-primary-pancreatic-mass-on-endoscopic-ultrasound-guided-fine-needle-aspiration
#7
Michael Chambers, Konrad Krall, Shantel Hébert-Magee
Metastases to the pancreas are much less common than primary pancreatic lesions, and there are few reports in the literature of metastatic urothelial carcinoma (UC) found in the pancreas. We report two cases of metastatic UC mimicking a primary pancreatic lesion. Two female patients, aged 48 and 83 years, presented with isolated pancreatic lesions causing obstructive jaundice suspicious for pancreatic adenocarcinoma and underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with rapid on-site evaluation (ROSE)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28411093/association-between-diet-inflammatory-index-and-osteoporotic-hip-fracture-in-elderly-chinese-population
#8
Zhe-Qing Zhang, Wen-Ting Cao, Nitin Shivappa, James R Hebert, Bao-Lin Li, Juan He, Xin-Yi Tang, Ya-Yong Liang, Yu-Ming Chen
BACKGROUND: Chronic inflammation provides the substrate for various mechanisms involved in osteoporotic fracture. The Dietary Inflammatory Index (DII) could shed light on the effect of the inflammatory potential of the diet on osteoporotic hip fracture. OBJECTIVE: This study tested the hypothesis that higher DII scores are associated with greater hip fracture risk in an elderly Chinese population. METHODS: A 1:1 age- (±3 years), sex- and region-matched case-control study of 1050 pairs (female/male: 781/269) of elderly (age range = 52-83 years) Chinese was conducted in Guangdong, China (2009-2015)...
April 11, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28405929/thermodynamics-in-cancers-opposing-interactions-between-ppar-gamma-and-the-canonical-wnt-beta-catenin-pathway
#9
REVIEW
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert
Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated receptor gamma (PPAR gamma) in cancers and their implications from an energetic and metabolic point of view. In numerous tissues, PPAR gamma activation induces inhibition of beta-catenin pathway, while the activation of the canonical WNT/beta-catenin pathway inactivates PPAR gamma. In most cancers but not all, PPAR gamma is downregulated while the WNT/beta-catenin pathway is upregulated...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28390945/intraoperative-factors-that-predict-the-successful-placement-of-essure-microinserts
#10
Chloé J Arthuis, Emmanuel G Simon, Thomas Hébert, Henri Marret
OBJECTIVE: To determine whether the number of coils visualized in the uterotubal junction at the end of hysteroscopic microinsert placement predicts successful tubal occlusion. DESIGN: Cohort retrospective study (Canadian Task Force classification II-2). SETTING: Department of obstetrics and gynecology in a teaching hospital. PATIENTS: One hundred and fifty-three women underwent tubal microinsert placement for permanent birth control from 2010 through 2014...
April 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28383256/phosphoproteomics-with-activated-ion-electron-transfer-dissociation
#11
Nicholas M Riley, Alexander S Hebert, Gerhard Dürnberger, Florian Stanek, Karl Mechtler, Michael S Westphall, Joshua J Coon
The ability to localize phosphosites to specific amino acid residues is crucial to translating phosphoproteomic data into biological meaningful contexts. In a companion manuscript ( Anal. Chem. 2017 , DOI: 10.1021/acs.analchem.7b00213 ), we described a new implementation of activated ion electron transfer dissociation (AI-ETD) on a quadrupole-Orbitrap-linear ion trap hybrid MS system (Orbitrap Fusion Lumos), which greatly improved peptide fragmentation and identification over ETD and other supplemental activation methods...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28383247/implementation-of-activated-ion-electron-transfer-dissociation-on-a-quadrupole-orbitrap-linear-ion-trap-hybrid-mass-spectrometer
#12
Nicholas M Riley, Michael S Westphall, Alexander S Hebert, Joshua J Coon
Using concurrent IR photoactivation during electron transfer dissociation (ETD) reactions, i.e., activated ion ETD (AI-ETD), significantly increases dissociation efficiency resulting in improved overall performance. Here we describe the first implementation of AI-ETD on a quadrupole-Orbitrap-quadrupole linear ion trap (QLT) hybrid MS system (Orbitrap Fusion Lumos) and demonstrate the substantial benefits it offers for peptide characterization. First, we show that AI-ETD can be implemented in a straightforward manner by fastening the laser and guiding optics to the instrument chassis itself, making alignment with the trapping volume of the QLT simple and robust...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28380932/self-corrected-chip-based-dual-comb-spectrometer
#13
Nicolas Bourbeau Hébert, Jérôme Genest, Jean-Daniel Deschênes, Hugo Bergeron, George Y Chen, Champak Khurmi, David G Lancaster
We present a dual-comb spectrometer based on two passively mode-locked waveguide lasers integrated in a single Er-doped ZBLAN chip. This original design yields two free-running frequency combs having a high level of mutual stability. We developed in parallel a self-correction algorithm that compensates residual relative fluctuations and yields mode-resolved spectra without the help of any reference laser or control system. Fluctuations are extracted directly from the interferograms using the concept of ambiguity function, which leads to a significant simplification of the instrument that will greatly ease its widespread adoption and commercial deployment...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28379929/associations-between-physician-empathy-physician-characteristics-and-standardized-measures-of-patient-experience
#14
Alexander Chaitoff, Bob Sun, Amy Windover, Daniel Bokar, Joseph Featherall, Michael B Rothberg, Anita D Misra-Hebert
PURPOSE: To identify correlates of physician empathy and determine whether physician empathy is related to standardized measures of patient experience. METHOD: Demographic, professional, and empathy data were collected during 2013-2015 from Cleveland Clinic Health System physicians prior to participation in mandatory communication skills training. Empathy was assessed using the Jefferson Scale of Empathy. Data were also collected for seven measures (six provider communication items and overall provider rating) from the visit-specific and 12-month Consumer Assessment of Healthcare Providers and Systems Clinician and Group (CG-CAHPS) surveys...
April 4, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28376792/dietary-inflammatory-index-and-risk-of-first-myocardial-infarction-a-prospective-population-based-study
#15
Stina Bodén, Maria Wennberg, Bethany Van Guelpen, Ingegerd Johansson, Bernt Lindahl, Jonas Andersson, Nitin Shivappa, James R Hebert, Lena Maria Nilsson
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up...
April 4, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28368304/pre-pregnancy-body-mass-index-is-associated-with-dietary-inflammatory-index-and-c-reactive-protein-concentrations-during-pregnancy
#16
Dayeon Shin, Junguk Hur, Eun-Hee Cho, Hae-Kyung Chung, Nitin Shivappa, Michael D Wirth, James R Hébert, Kyung Won Lee
There have been a limited number of studies examining the association between pre-pregnancy body mass index (BMI) and dietary inflammation during pregnancy. Our aim is to examine the association between pre-pregnancy BMI and the Dietary Inflammatory Index (DII)™ and C-reactive protein (CRP) concentrations during pregnancy. The study included 631 pregnant American women from the National Health and Nutrition Examination Survey (NHANES) cross-sectional examinations from 2003 to 2012. Pre-pregnancy BMI was calculated based on self-reported pre-pregnancy weight and measured height...
April 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28364023/rna-activation-independent-dna-targeting-of-the-type-iii-crispr-cas-system-by-a-csm-complex
#17
Kwang-Hyun Park, Yan An, Tae-Yang Jung, In-Young Baek, Haemin Noh, Woo-Chan Ahn, Hans Hebert, Ji-Joon Song, Jeong-Hoon Kim, Byung-Ha Oh, Eui-Jeon Woo
The CRISPR-Cas system is an adaptive and heritable immune response that destroys invading foreign nucleic acids. The effector complex of the Type III CRISPR-Cas system targets RNA and DNA in a transcription-coupled manner, but the exact mechanism of DNA targeting by this complex remains elusive. In this study, an effector Csm holocomplex derived from Thermococcus onnurineus is reconstituted with a minimalistic combination of Csm1121334151, and shows RNA targeting and RNA-activated single-stranded DNA (ssDNA) targeting activities...
March 31, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28361111/perspectives-of-patients-caregivers-and-researchers-on-research-priorities-in-donation-and-transplantation-in-canada-a-pilot-workshop
#18
Julie Allard, Céline Durand, Samantha J Anthony, Vincent Dumez, David Hartell, Marie-Josée Hébert, Lori J West, Linda Wright, Marie-Chantal Fortin
BACKGROUND: It is vitally important to seek input from key stakeholders to increase the quality and relevance of health-related research and accelerate its adoption into practice. Patients and caregivers have rarely been involved in setting research priorities in the transplantation and donation field. The objectives of this explorative study are: (i) to discuss research priorities within the Canadian National Transplant Research Program during a priority-setting exercise with patients, caregivers, organ donors and researchers and (ii) to compare the identified priorities with research published in 2 prestigious transplantation journals...
February 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28360267/decoupling-genetics-lineages-and-microenvironment-in-idh-mutant-gliomas-by-single-cell-rna-seq
#19
Andrew S Venteicher, Itay Tirosh, Christine Hebert, Keren Yizhak, Cyril Neftel, Mariella G Filbin, Volker Hovestadt, Leah E Escalante, McKenzie L Shaw, Christopher Rodman, Shawn M Gillespie, Danielle Dionne, Christina C Luo, Hiranmayi Ravichandran, Ravindra Mylvaganam, Christopher Mount, Maristela L Onozato, Brian V Nahed, Hiroaki Wakimoto, William T Curry, A John Iafrate, Miguel N Rivera, Matthew P Frosch, Todd R Golub, Priscilla K Brastianos, Gad Getz, Anoop P Patel, Michelle Monje, Daniel P Cahill, Orit Rozenblatt-Rosen, David N Louis, Bradley E Bernstein, Aviv Regev, Mario L Suvà
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between IDH-mutant astrocytoma and oligodendroglioma can be primarily explained by distinct TME and signature genetic events, whereas both tumor types share similar developmental hierarchies and lineages of glial differentiation...
March 31, 2017: Science
https://www.readbyqxmd.com/read/28356432/the-inflammatory-potential-of-the-diet-is-associated-with-depressive-symptoms-in-different-subgroups-of-the-general-population
#20
Moufidath Adjibade, Valentina A Andreeva, Cédric Lemogne, Mathilde Touvier, Nitin Shivappa, James R Hébert, Michael D Wirth, Serge Hercberg, Pilar Galan, Chantal Julia, Karen E Assmann, Emmanuelle Kesse-Guyot
Background: Low-grade chronic inflammation, which can be modulated by diet, has been suggested as an important risk factor for depression, but few studies have investigated the association between the inflammatory potential of the diet and depression.Objective: We investigated the prospective association between the inflammatory potential of the diet, measured by the Dietary Inflammatory Index (DII), and incident depressive symptoms and tested the potential modulating effect of sex, age, physical activity, and smoking status...
March 29, 2017: Journal of Nutrition
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