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https://www.readbyqxmd.com/read/28222283/systematic-mapping-of-rna-chromatin-interactions-in%C3%A2-vivo
#1
Bharat Sridhar, Marcelo Rivas-Astroza, Tri C Nguyen, Weizhong Chen, Zhangming Yan, Xiaoyi Cao, Lucie Hebert, Sheng Zhong
No abstract text is available yet for this article.
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28216327/combined-whole-body-and-multi-parametric-prostate-mri-as-a-single-step-approach-for-the-simultaneous-assessment-of-local-recurrence-and-metastatic-disease-after-radical-prostatectomy
#2
Nicola L Robertson, Evis Sala, Matthias Benz, Jonathan Landa, Peter Scardino, Howard I Scher, Hedvig Hricak, Hebert A Vargas
PURPOSE: To report our initial experience using "whole body and dedicated prostate (WB+P)" MRI as a single exam for the assessment of local recurrence and metastatic disease in patients with suspected recurrent prostate cancer (PCa) after radical prostatectomy (RP). MATERIALS AND METHODS: IRB-approved retrospective single-center study. 76 consecutive patients with clinically suspected recurrent PCa following RP underwent combined WB+P-MRI in a single session (10/2014-01/2016)...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28213606/parental-health-literacy-and-outcomes-of-childhood-nephrotic-syndrome
#3
Karlota Borges, Cathryn Sibbald, Neesha Hussain-Shamsy, Jovanka Vasilevska-Ristovska, Tonny Banh, Viral Patel, Josefina Brooke, Monica Piekut, Michele Reddon, Kimberly Aitken-Menezes, Ashley McNaughton, Rachel J Pearl, Valerie Langlois, Seetha Radhakrishnan, Christoph P B Licht, Tino D Piscione, Leo Levin, Damien Noone, Diane Hebert, Rulan S Parekh
OBJECTIVE: Determine the association of parental health literacy with treatment response among children with nephrotic syndrome. METHODS: This was a cohort study of children aged 1-18 with nephrotic syndrome and their parent. Health literacy was measured using the validated Short Test of Functional Health Literacy in Adults assessing reading comprehension and numeracy. Outcomes included initial relapse-free period, frequently relapsing disease, relapse rate, second-line medication use, and complete remission after therapy...
February 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/28213525/conformational-profiling-of-the-at1-angiotensin-ii-receptor-reflects-biased-agonism-g-protein-coupling-and-cellular-context
#4
Dominic Devost, Rory Sleno, Darlaine Petrin, Alice Zhang, Yuji Shinjo, Rakan Okde, Junken Aoki, Asuka Inoue, Terence E Hebert
Here, we report the design and use of GPCR-based biosensors to monitor ligand-mediated conformational changes in receptors in intact cells. These biosensors use Bioluminescence Resonance Energy Transfer (BRET) with Renilla luciferase (RlucII) as an energy donor, placed at the distal end of the receptor C-tail and the small fluorescent molecule FlAsH, as an energy acceptor, its binding site inserted at different positions throughout the intracellular loops and carboxy-terminal tail of the angiotensin II type I receptor (AT1R)...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28212762/sensitivity-and-specificity-of-bp180-nc16a-enzyme-linked-immunosorbent-assay-for-the-diagnosis-of-pemphigoid-gestationis
#5
Fatimah Al Saif, Fabienne Jouen, Vivien Hebert, Helene Chiavelli, Basma Darwish, Sophie Duvert-Lehembre, Pascal Joly
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28211886/a-novel-approach-for-the-identification-of-efficient-combination-therapies-in-primary-human-acute-myeloid-leukemia-specimens
#6
I Baccelli, J Krosl, G Boucher, I Boivin, V-P Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
Appropriate culture methods for the interrogation of primary leukemic samples were hitherto lacking and current assays for compound screening are not adapted for large-scale investigation of synergistic combinations. In this study, we report a novel approach that efficiently distills synthetic lethal interactions between small molecules active on primary human acute myeloid leukemia (AML) specimens. In single-dose experiments and under culture conditions preserving leukemia stem cell activity, our strategy considerably reduces the number of tests needed for the identification of promising compound combinations...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28208475/exotic-phase-transitions-of-k-cores-in-clustered-networks
#7
Uttam Bhat, Munik Shrestha, Laurent Hébert-Dufresne
The giant k-core-maximal connected subgraph of a network where each node has at least k neighbors-is important in the study of phase transitions and in applications of network theory. Unlike Erdős-Rényi graphs and other random networks where k-cores emerge discontinuously for k≥3, we show that transitive linking (or triadic closure) leads to 3-cores emerging through single or double phase transitions of both discontinuous and continuous nature. We also develop a k-core calculation that includes clustering and provides insights into how high-level connectivity emerges...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207975/stabilization-of-renal-function-after-the-first-year-of-follow-up-in-kidney-transplant-recipients-treated-for-significant-bk-polyomavirus-infection-or-bk-polyomavirus-associated-nephropathy
#8
Marie-Christine Simard-Meilleur, Paule Bodson-Clermont, Gilles St-Louis, Michel R Pâquet, Catherine Girardin, Marie-Chantal Fortin, Héloïse Cardinal, Marie-Josée Hébert, Reneé Lévesque, Edith Renoult
BACKGROUND: BK polyomavirus virus (BKPyV) screening and immunosuppression reduction effectively prevent graft loss due to BKPyV-associated nephropathy (BKPVAN) during the first year after transplantation. The aim of our study was to evaluate the impact of this infection during longer follow-up periods. METHODS: We reviewed the outcome of our screening and immunosuppression reduction protocol in 305 patients who received a kidney transplant between March 2008 and January 2013...
February 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28202389/targeting-the-hdac2-hnf-4a-mir-101b-ampk-pathway-rescues-tauopathy-and-dendritic-abnormalities-in-alzheimer-s-disease
#9
Dan Liu, Hui Tang, Xin-Yan Li, Man-Fei Deng, Na Wei, Xiong Wang, Ya-Fan Zhou, Ding-Qi Wang, Peng Fu, Jian-Zhi Wang, Sébastien S Hébert, Jian-Guo Chen, Youming Lu, Ling-Qiang Zhu
Histone deacetylase 2 (HDAC2) plays a major role in the epigenetic regulation of gene expression. Previous studies have shown that HDAC2 expression is strongly increased in Alzheimer's disease (AD), a major neurodegenerative disorder and the most common form of dementia. Moreover, previous studies have linked HDAC2 to Aβ overproduction in AD; however, its involvement in tau pathology and other memory-related functions remains unclear. Here, we show that increased HDAC2 levels strongly correlate with phosphorylated tau in a mouse model of AD...
February 12, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28202323/cumulative-adverse-childhood-experiences-and-sexual-satisfaction-in-sex-therapy-patients-what-role-for-symptom-complexity
#10
Noémie Bigras, Natacha Godbout, Martine Hébert, Stéphane Sabourin
INTRODUCTION: Patients consulting for sexual difficulties frequently present additional personal or relational disorders and symptoms. This is especially the case when they have experienced cumulative adverse childhood experiences (CACEs), which are associated with symptom complexity. CACEs refer to the extent to which an individual has experienced an accumulation of different types of adverse childhood experiences including sexual, physical, and psychological abuse; neglect; exposure to inter-parental violence; and bullying...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28199861/the-vato-project-development-and-validation-of-a-dynamic-transfer-model-of-tritium-in-grassland-ecosystem
#11
S Le Dizès, C Aulagnier, D Maro, M Rozet, F Vermorel, D Hébert, C Voiseux, L Solier, C Godinot, B Fievet, P Laguionie, O Connan, O Cazimajou, M Morillon
In this paper, a dynamic compartment model with a high temporal resolution has been investigated to describe tritium transfer in grassland ecosystems exposed to atmospheric (3)H releases from nuclear facilities under normal operating or accidental conditions. TOCATTA-χ model belongs to the larger framework of the SYMBIOSE modelling and simulation platform that aims to assess the fate and transport of a wide range of radionuclides in various environmental systems. In this context, the conceptual and mathematical models of TOCATTA-χ have been designed to be relatively simple, minimizing the number of compartments and input parameters required...
February 12, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28199177/comment-on-decisional-conflict-regret-and-the-burden-of-rational-decision-making
#12
Anita D Misra-Hebert, Michael W Kattan
No abstract text is available yet for this article.
February 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28193086/association-between-inflammatory-potential-of-diet-and-stress-levels-in-adolescent-women-in-iran
#13
Nitin Shivappa, James R Hebert, Bahram Rashidkhani
BACKGROUND: The relation between diet and stress has not been widely explored. In this study, we examined the association between the inflammatory potential of diet and levels of stress among adolescent girls in Iran. METHODS: A total of 299 adolescent girls aged 15-18 years were recruited during 2014-2015. Stress was assessed using the Depression, Anxiety and Stress Scale (DASS)-21 scale. Data were analyzed as continuous DASS scores and as a dichotomous outcome with a cut-off value of 9...
February 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28187722/effectiveness-of-differing-levels-of-support-for-family-meals-on-obesity-prevention-among-head-start-preschoolers-the-simply-dinner-study
#14
Holly E Brophy-Herb, Mildred Horodynski, Dawn Contreras, Jean Kerver, Niko Kaciroti, Mara Stein, Hannah Jong Lee, Brittany Motz, Sheilah Hebert, Erika Prine, Candace Gardiner, Laurie A Van Egeren, Julie C Lumeng
BACKGROUND: Despite slight decreases in obesity prevalence in children, nearly 25% of preschool-aged children are overweight or obese. Most interventions focused on promoting family meals as an obesity-prevention strategy target meal planning skills, knowledge and modeling of healthy eating without addressing the practical resources that enable implementation of family meals. There is a striking lack of evidence about what level of resources low-income parents need to implement family meals...
February 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28182863/randomized-controlled-trial-of-a-community-health-worker-self-management-support-intervention-among-low-income-adults-with-diabetes-seattle-washington-2010-2014
#15
Karin Nelson, Leslie Taylor, Julie Silverman, Meghan Kiefer, Paul Hebert, Dan Lessler, James Krieger
INTRODUCTION: Community health workers (CHWs) can improve diabetes outcomes; however, questions remain about translating research findings into practical low-intensity models for safety-net providers. We tested the effectiveness of a home-based low-intensity CHW intervention for improving health outcomes among low-income adults with diabetes. METHODS: Low-income patients with glycated hemoglobin A1c (HbA1c) of 8.0% or higher in the 12 months before enrollment from 3 safety-net providers were randomized to a 12-month CHW-delivered diabetes self-management intervention or usual care...
February 9, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28179489/the-dietary-inflammatory-index-is-associated-with-colorectal-cancer-risk-in-the-multiethnic-cohort
#16
Brook E Harmon, Michael D Wirth, Carol J Boushey, Lynne R Wilkens, Emma Draluck, Nitin Shivappa, Susan E Steck, Lorne Hofseth, Christopher A Haiman, Loic Le Marchand, James R Hébert
Background: Diet is known to influence systemic inflammation, a recognized risk factor for colorectal cancer (CRC). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and CRC incidence are limited.Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and CRC incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of CRC, and that these associations may differ across racial/ethnic groups...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28177841/dna-barcoding-as-an-aid-for-species-identification-in-austral-black-flies-insecta-diptera-simuliidae
#17
Luis Miguel Hernandez-Triana, Fernanda Montes DE Oca, Sean W J Prosser, Paul D N Hebert, Ryan Gregory, Shelley McMurtrie
In this paper, the utility of a partial sequence of the COI gene, the DNA barcoding region, for the identification of species of black flies in the Austral Region was assessed. Twenty eight morphospecies were analysed, 8 in the genus Austrosimulium (4 species in the subgenus Austrosimulium s.str., 3 in the subgenus Novaustrosimulium, and 1 species unassigned to subgenus), 2 of the genus Cnesia, 8 of Gigantodax, 3 of Paracnephia, 1 Paraustrosimulium and 4 species to Simulium, subgenera (Morops, Nevermannia, and Pternaspatha)...
November 21, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28177734/association-between-dietary-inflammatory-index-dii-and-risk-of-pre-diabetes-a-case-control-study
#18
Farhad Vahid, Nitin Shivappa, Mohsen Karamati, Alireza Jafari Naeini, James R Hebert, Sayed Hossein Davoodi
BACKGROUND: The possible relationship between diet-related inflammation and the risk of pre-diabetes requires further investigation, especially in non-Western populations. We examined the ability of the dietary inflammatory index (DII) to predict the risk of pre-diabetes in a case-control study conducted at specialized centers in Esfahan, Iran. METHODS: A total of 214 incident cases of pre-diabetes were selected with the non-random sampling procedure; and 200 controls randomly selected from the same clinics were frequency-matched on age (±5 years) and sex...
December 15, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177722/association-between-maternal-dietary-inflammatory-index-dii-and-abortion-in-iranian-women-and-validation-of-dii-with-serum-concentration-of-inflammatory-factors-case-control-study
#19
Farhad Vahid, Nitin Shivappa, Azita Hekmatdoost, James R Hebert, Sayed Hossein Davoodi, Mohammadreza Sadeghi
BACKGROUND: Previous studies have shown that some dietary components may be implicated in the etiology of abortion. However, the possible relationship between diet-related inflammation and the risk of abortion has not yet been investigated. METHODS: We examined the ability of the literature-derived dietary inflammatory index (DII) to predict the abortion incidence in women suffering from recurrent abortion in a case-control study conducted from April 2010 to March 2011...
January 9, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28175463/142%C3%A2-genetic-and-nongenetic-determinants-of-cellular-architecture-in-idh1-mutant-oligodendrogliomas-and-astrocytomas-using-single-cell-transcriptome-analysis
#20
Andrew Sean Venteicher, Itay Tirosh, Christine Hebert, Leah Escalante, Robert L Martuza, Brian V Nahed, William T Curry, Daniel P Cahill, Bradley Bernstein, David N Louis, Aviv Regev, Mario Suva
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
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