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https://www.readbyqxmd.com/read/29029109/early-diagnosis-of-acute-coronary-syndrome
#1
Hugo Katus, André Ziegler, Okan Ekinci, Evangelos Giannitsis, Wendy Gattis Stough, Stephan Achenbach, Stefan Blankenberg, Martina Brueckmann, Paul Collinson, Dorin Comaniciu, Filippo Crea, Wilfried Dinh, Grégory Ducrocq, Frank A Flachskampf, Keith A A Fox, Matthias G Friedrich, Kathy A Hebert, Anders Himmelmann, Mark Hlatky, Dominik Lautsch, Bertil Lindahl, Daniel Lindholm, Nicholas L Mills, Giorgio Minotti, Martin Möckel, Torbjørn Omland, Véronique Semjonow
The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29025058/cohort-profile-genetics-of-diabetes-audit-and-research-in-tayside-scotland-godarts
#2
Harry L Hébert, Bridget Shepherd, Keith Milburn, Abirami Veluchamy, Weihua Meng, Fiona Carr, Louise A Donnelly, Roger Tavendale, Graham Leese, Helen M Colhoun, Ellie Dow, Andrew D Morris, Alexander S Doney, Chim C Lang, Ewan R Pearson, Blair H Smith, Colin N A Palmer
No abstract text is available yet for this article.
September 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024625/effect-of-health-plan-financial-incentive-offering-on-employees-with-prediabetes
#3
Anita D Misra-Hebert, Bo Hu, Phuc H Le, Michael B Rothberg
Background Prediabetes may be improved or reversed with lifestyle interventions. A worksite wellness program offering financial incentives for participation may be effective in improving the health of employees with prediabetes. We studied the effect of employee health plan financial incentives on health outcomes for employees with prediabetes. Methods We conducted a retrospective cohort study using electronic medical record (EMR) data from January 2008- December 2012. Our study participants were employees with prediabetes and propensity-matched non-employees with prediabetes and commercial health insurance, all receiving care within one health system...
October 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29019343/the-association-between-dietary-inflammatory-properties-and-bone-mineral-density-and-risk-of-fracture-in-us-adults
#4
M Mazidi, N Shivappa, M D Wirth, J R Hebert, H Vatanparast, A P Kengne
BACKGROUND/OBJECTIVES: To examine the associations of dietary inflammatory index (DII) with bone mineral density (BMD) and fracture risk in adult Americans.Subjects/Method:The United States National Health and Nutrition Examination Survey participants during 2005-2010 were included if they had measured data on dietary intake and BMD. DII scores were calculated from estimated micro- and macronutrients from a single 24-h dietary recall. BMD was measured using dual-energy X-ray absorptiometry densitometers...
October 11, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29018920/pro-inflammatory-dietary-pattern-is-associated-with-fractures-in-women-an-eight-year-longitudinal-cohort-study
#5
N Veronese, B Stubbs, A Koyanagi, J R Hébert, C Cooper, M G Caruso, G Guglielmi, J Y Reginster, R Rizzoli, S Maggi, N Shivappa
In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders. INTRODUCTION: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people...
October 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29017757/effects-of-retinoic-acid-signaling-on-extraocular-muscle-myogenic-precursor-cells-in-vitro
#6
Sadie L Hebert, Krysta R Fitzpatrick, Samantha A McConnell, Anja Cucak, Ching Yuan, Linda K McLoon
One major difference between limb and extraocular muscles (EOM) is the presence of an enriched population of Pitx2-positive myogenic precursor cells in EOM compared to limb muscle. We hypothesize that retinoic acid regulates Pitx2 expression in EOM myogenic precursor cells and that its effects would differ in leg muscle. The two muscle groups expressed differential retinoic acid receptor (RAR) and retinoid X receptor (RXR) levels. RXR co-localized with the Pitx2-positive cells but not with those expressing Pax7...
October 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28990552/-mitochondria-link-between-cannabinoid-and-memory
#7
Étienne Hébert-Chatelain, Giovanni Marsicano
No abstract text is available yet for this article.
June 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28988195/eus-guided-fine-needle-biopsy-of-pancreatic-masses-can-yield-true-histology-results-of-a-randomised-trial
#8
Ji Young Bang, Shantel Hebert-Magee, Udayakumar Navaneethan, Muhammad K Hasan, Robert Hawes, Shyam Varadarajulu
No abstract text is available yet for this article.
October 7, 2017: Gut
https://www.readbyqxmd.com/read/28985169/cervical-cancer-in-african-american-women-optimizing-prevention-to-reduce-disparities
#9
EDITORIAL
Anita D Misra-Hebert
No abstract text is available yet for this article.
October 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28981317/an-analysis-of-avoidant-and-approach-coping-as-mediators-of-the-relationship-between-paternal-and-maternal-attachment-security-and-outcomes-in-child-victims-of-sexual-abuse
#10
Martine Hébert, Marie-Ève Daspe, Mireille Cyr
OBJECTIVE: Prior studies have documented the potential role of nonoffending parent support in promoting recovery of adult survivors following sexual abuse (SA). However, few studies have distinguished the maternal and paternal role and the mechanisms by which quality of the parent-child relationship might foster more positive outcomes in child victims. The purpose of this study was to examine coping strategies as mediators of the link between mother-child and father-child relationship and outcomes following child SA...
October 5, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28976724/impact-of-glycemic-control-on-the-diabetes-complications-severity-index-score-and-development-of-complications-in-people-with-newly-diagnosed-type-2-diabetes
#11
Kevin M Pantalone, Anita D Misra-Hebert, Todd M Hobbs, Brian J Wells, Sheldon X Kong, Kevin Chagin, Tanujit Dey, Adam Milinovich, Wayne Weng, Janine M Bauman, Bartolome Burguera, Robert S Zimmerman, Michael W Kattan
AIMS: To assess the longitudinal accumulation of diabetes-related complications and the impact of glycemic control on the diabetes complications severity index (DCSI) score in people with newly-diagnosed type 2 diabetes (T2D). METHODS: A retrospective cohort study was conducted using electronic health records (EHR) from a large integrated healthcare system. People with newly-diagnosed T2D were identified between 2005-2016 and stratified by initial glycosylated hemoglobin (A1C) category (<7%, <8%, ≥8%)...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28976313/assessment-of-rigid-registration-quality-measures-in-ultrasound-guided-radiotherapy
#12
Roozbeh Shams, Yiming Xiao, Francois Hebert, Matthew Abramowitz, Rupert Brooks, Hassan Rivaz
Image guidance has become the standard of care for patient positioning in radiotherapy, where image registration is often a critical step to help manage patient motion. However, in practice, verification of registration quality is often adversely affected by difficulty in manual inspection of 3D images and time constraint, thus affecting the therapeutic outcome. Therefore, we proposed to employ both bootstrapping and the supervised learning methods of linear discriminant analysis and random forest to help robustly assess registration quality in ultrasound-guided radiotherapy...
September 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28965984/a-novel-microrna-124-ptpn1-signal-pathway-mediates-synaptic-and-memory-deficits-in-alzheimer-s-disease
#13
Xiong Wang, Dan Liu, He-Zhou Huang, Zhi-Hao Wang, Tong-Yao Hou, Xin Yang, Pei Pang, Na Wei, Ya-Fan Zhou, Marie-Josée Dupras, Frédéric Calon, Yu-Tian Wang, Heng-Ye Man, Jian-Guo Chen, Jian-Zhi Wang, Sébastien S Hébert, Youming Lu, Ling-Qiang Zhu
BACKGROUND: Synaptic loss is an early pathological event in Alzheimer's disease (AD), but its underlying molecular mechanisms remain largely unknown. Recently, microRNAs (miRNAs) have emerged as important modulators of synaptic function and memory. METHODS: We used miRNA array and quantitative polymerase chain reaction to examine the alteration of miRNAs in AD mice and patients as well as the Morris water maze to evaluate learning and memory in the mice. We also used adeno-associated virus or lentivirus to introduce tyrosine-protein phosphatase non-receptor type 1 (PTPN1) expression of silencing RNAs...
August 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28957369/medication-adherence-medical-record-accuracy-and-medication-exposure-in-real-world-patients-using-comprehensive-medication-monitoring
#14
Timothy P Ryan, Ryan D Morrison, Jeffrey J Sutherland, Stephen B Milne, Kendall A Ryan, J Scott Daniels, Anita Misra-Hebert, J Kevin Hicks, Eric Vogan, Kathryn Teng, Thomas M Daly
BACKGROUND: Poor adherence to medication regimens and medical record inconsistencies result in incomplete knowledge of medication therapy in polypharmacy patients. By quantitatively identifying medications in the blood of patients and reconciling detected medications with the medical record, we have defined the severity of this knowledge gap and created a path toward optimizing medication therapy. METHODS AND FINDINGS: We validated a liquid chromatography-tandem mass spectrometry assay to detect and/or quantify 38 medications across a broad range of chronic diseases to obtain a comprehensive survey of patient adherence, medical record accuracy, and exposure variability in two patient populations...
2017: PloS One
https://www.readbyqxmd.com/read/28952050/gender-diversity-in-a-stem-subfield-analysis-of-a-large-scientific-society-and-its-annual-conferences
#15
Evgenia Shishkova, Nicholas W Kwiecien, Alexander S Hebert, Michael S Westphall, Jessica E Prenni, Joshua J Coon
Speaking engagements, serving as session chairs, and receiving awards at national meetings are essential stepping stones towards professional success for scientific researchers. Studies of gender parity in meetings of national scientific societies repeatedly uncover bias in speaker selection, engendering underrepresentation of women among featured presenters. To continue this dialogue, we analyzed membership data and annual conference programs of a large scientific society (>7000 members annually) in a male-rich (~70% males), technology-oriented STEM subfield...
September 26, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28950945/adhesion-gpcrs-in-regulating-immune-responses-and-inflammation
#16
Hsi-Hsien Lin, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg, Jörg Hamann
The adhesion family comprises one of the five major clades of G protein-coupled receptors (GPCRs). Unlike conventional GPCRs, adhesion GPCRs (aGPCRs) have extended ectodomains with various protein folds that facilitate protein-protein interactions and, hence, putative cellular adhesive functions. Juxtaposed to the seven-pass transmembrane domain is a GPCR autoproteolysis-inducing domain that enables autoproteolytic cleavage of the receptor, resulting in a bipartite structure of many aGPCRs. aGPCRs are widely distributed and play critical roles in many developmental processes; yet, the underlying mechanisms of activation and signal transduction have emerged only recently...
2017: Advances in Immunology
https://www.readbyqxmd.com/read/28943182/the-relationship-between-the-dietary-inflammatory-index-and-incident-frailty-a-longitudinal-cohort-study
#17
Nitin Shivappa, Brendon Stubbs, James R Hébert, Matteo Cesari, Patricia Schofield, Pinar Soysal, Stefania Maggi, Nicola Veronese
OBJECTIVE: Inflammation is key risk factor for several conditions in the elderly. However, the relationship between inflammation and frailty is still unclear. We investigated whether higher dietary inflammatory index (DII) scores were associated with higher incidence of frailty in a cohort of North Americans. DESIGN: Longitudinal, with a follow-up of 8 years. SETTING: Osteoarthritis Initiative. PARTICIPANTS: A total of 4421 participants with, or at high risk of, knee osteoarthritis...
September 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28938289/discussing-benefits-and-risks-of-tracheostomy-what-physicians-actually-say
#18
Lauren M Hebert, Anne C Watson, Vanessa Madrigal, Tessie W October
OBJECTIVES: When contemplating tracheostomy placement in a pediatric patient, a family-physician conference is often the setting for the disclosure of risks and benefits of the procedure. Our objective was to compare benefits and risks of tracheostomy presented during family-physician conferences to an expert panel's recommendations for what should be presented. DESIGN: We conducted a retrospective review of 19 transcripts of audio-recorded family-physician conferences regarding tracheostomy placement in children...
September 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28938252/emotional-impact-of-end-of-life-decisions-on-professional-relationships-in-the-icu-an-obstacle-to-collegiality
#19
Alexandra Laurent, Magalie Bonnet, Gilles Capellier, Pierre Aslanian, Paul Hebert
OBJECTIVES: End-of-life decisions are not only common in the ICU but also frequently elicit strong feelings among health professionals. Even though we seek to develop more collegial interprofessional approaches to care and health decision-making, there are many barriers to successfully managing complex decisions. The aim of this study is to better understand how emotions influence the end-of-life decision-making process among professionals working in ICU. DESIGN: Qualitative study with clinical interviews...
September 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28937801/clinical-implications-of-hand-position-and-lower-limb-length-measurement-method-on-y-balance-test-scores-and-interpretation
#20
Kim Hébert-Losier
CONTEXT:   The Lower Quarter Y-Balance Test (LQ-YBT) was developed to provide an effective and efficient screen for injury risk in sports. Earlier protocol recommendations for the LQ-YBT involved the athlete placing the hands on the hips and the clinician normalizing scores to lower limb length measured from the anterior-superior iliac spine to the lateral malleolus. The updated LQ-YBT protocol recommends the athlete's hands be free moving and the clinician measure lower limb length to the medial malleolus...
September 22, 2017: Journal of Athletic Training
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