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https://www.readbyqxmd.com/read/29676034/stable-baselines-of-temporal-turnover-underlie-high-beta-diversity-in-tropical-arthropod-communities
#1
Michelle L D'Souza, Paul D N Hebert
While the high species diversity of tropical arthropod communities has often been linked to marked spatial heterogeneity, their temporal dynamics have received little attention. This study addresses this gap by examining spatio-temporal variation in the arthropod communities of a tropical montane forest in Honduras. By employing DNA barcode analysis and Malaise trap sampling across four years and five sites, 51,596 specimens were assigned to 8,193 presumptive species. High beta diversity was linked more strongly to elevation than geographic distance, decreasing by 12% when only the dominant species were considered...
April 19, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29675557/association-between-the-dietary-inflammatory-index-dii-and-urinary-enterolignans-and-c-reactive-protein-from-the-national-health-and-nutrition-examination-survey-2003-2008
#2
Nitin Shivappa, Michael D Wirth, E Angela Murphy, Thomas G Hurley, James R Hébert
BACKGROUND: Enterolignans are important biomarkers of microbiota diversity, with higher levels indicating greater diversity. Diet and inflammation have been shown to play a role in maintaining microbiota diversity. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory Index (DII® ) has an impact on levels of urinary enterolignans in the National Health and Nutrition Examination Survey (NHANES) 2003-2008. We also carried out construct validation of the DII with C-reactive protein (CRP)...
April 19, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29674595/developmental-and-oncogenic-programs-in-h3k27m-gliomas-dissected-by-single-cell-rna-seq
#3
Mariella G Filbin, Itay Tirosh, Volker Hovestadt, McKenzie L Shaw, Leah E Escalante, Nathan D Mathewson, Cyril Neftel, Nelli Frank, Kristine Pelton, Christine M Hebert, Christine Haberler, Keren Yizhak, Johannes Gojo, Kristof Egervari, Christopher Mount, Peter van Galen, Dennis M Bonal, Quang-De Nguyen, Alexander Beck, Claire Sinai, Thomas Czech, Christian Dorfer, Liliana Goumnerova, Cinzia Lavarino, Angel M Carcaboso, Jaume Mora, Ravindra Mylvaganam, Christina C Luo, Andreas Peyrl, Mara Popović, Amedeo Azizi, Tracy T Batchelor, Matthew P Frosch, Maria Martinez-Lage, Mark W Kieran, Pratiti Bandopadhayay, Rameen Beroukhim, Gerhard Fritsch, Gad Getz, Orit Rozenblatt-Rosen, Kai W Wucherpfennig, David N Louis, Michelle Monje, Irene Slavc, Keith L Ligon, Todd R Golub, Aviv Regev, Bradley E Bernstein, Mario L Suvà
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29673757/the-effects-of-cryoprotectants-on-sperm-motility-of-the-chinese-pearl-oyster-pinctada-fucata-martensii
#4
Xing Zheng, Zhifeng Gu, Zhiwei Huang, Haifeng Ding, Hebert Ely Vasquez, Yibing Liu, Yaohua Shi, Aimin Wang
Cryopreservation has been widely employed to preserve genetic material of aquatic animals. Although of common use in bivalves, resulting effects due to the toxicity of the cryoprotectants dimethyl sulfoxide (DMSO), propanediol (PG), methanol (MET) and ethylene glycol (EG), upon sperm motility in the Chinese pearl oyster, Pinctada fucata martensii, has remained undocumented. This study endeavors to identify the least toxic among the effective cryoprotectant agents by observing and comparing their toxic effects on sperm motility under varying concentrations and duration of exposure...
April 16, 2018: Cryobiology
https://www.readbyqxmd.com/read/29672869/age-of-transfused-blood-in-critically-ill-adult-trauma-patients-a-prespecified-nested-analysis-of-the-age-of-blood-evaluation-randomized-trial
#5
Robert S Green, Mete Erdogan, Jacques Lacroix, Paul C Hébert, Alan T Tinmouth, Elham Sabri, Tinghua Zhang, Dean A Fergusson, Alexis F Turgeon
BACKGROUND: Blood transfusion is common in the resuscitation of patients with traumatic injury. However, the clinical impact of the length of storage of transfused blood is unclear in this population. STUDY DESIGN AND METHODS: We undertook a prespecified nested analysis of 372 trauma victims of the 2510 critically ill patients from 64 centers treated as part of the Age of Blood Evaluation (ABLE) randomized controlled trial. Patients were randomized according to their trauma status to receive either a transfusion of fresh blood stored not more than 7 days or standard-issue blood...
April 19, 2018: Transfusion
https://www.readbyqxmd.com/read/29670379/assessment-of-an-accessorized-pre-filled-syringe-for-home-administered-benralizumab-in-severe-asthma
#6
Gary T Ferguson, Adel H Mansur, Joshua S Jacobs, Jacques Hebert, Corbin Clawson, Wenli Tao, Yanping Wu, Mitchell Goldman
Background: Patients prefer at-home subcutaneous administration of biologics across different diseases, yet no biologic is approved for at-home use for severe, uncontrolled asthma. Objective: We assessed at-home functionality, reliability, and performance of an accessorized pre-filled syringe (APFS) for subcutaneous benralizumab administration, an anti-eosinophil monoclonal antibody indicated for add-on maintenance treatment of patients with severe eosinophilic asthma...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29668651/examining-trends-in-obstetric-quality-measures-for-monitoring-health-care-disparities
#7
Teresa Janevic, Natalia N Egorova, Jennifer Zeitlin, Amy Balbierz, Paul L Hebert, Elizabeth A Howell
BACKGROUND: Elective delivery (ED) before 39 weeks, low-risk cesarean delivery, and episiotomy are routinely reported obstetric quality measures and have been the focus of quality improvement initiatives over the past decade. OBJECTIVE: To estimate trends and differences in obstetric quality measures by race/ethnicity. RESEARCH DESIGN: We used 2008-2014 linked birth certificate-hospital discharge data from New York City to measure ED before 39 gestational weeks (ED <39), low-risk cesarean, and episiotomy by race/ethnicity...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29666368/a-large-planetary-body-inferred-from-diamond-inclusions-in-a-ureilite-meteorite
#8
Farhang Nabiei, James Badro, Teresa Dennenwaldt, Emad Oveisi, Marco Cantoni, Cécile Hébert, Ahmed El Goresy, Jean-Alix Barrat, Philippe Gillet
Planetary formation models show that terrestrial planets are formed by the accretion of tens of Moon- to Mars-sized planetary embryos through energetic giant impacts. However, relics of these large proto-planets are yet to be found. Ureilites are one of the main families of achondritic meteorites and their parent body is believed to have been catastrophically disrupted by an impact during the first 10 million years of the solar system. Here we studied a section of the Almahata Sitta ureilite using transmission electron microscopy, where large diamonds were formed at high pressure inside the parent body...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661051/association-between-inflammatory-potential-of-diet-and-odds-of-gestational-diabetes-mellitus-among-iranian-women
#9
Nitin Shivappa, James R Hébert, Mahdieh Akhoundan, Parvin Mirmiran, Bahram Rashidkhani
BACKGROUND: The possible relationship between diet-related inflammation and the risk of gestational diabetes mellitus (GDM) requires further investigation, especially in non-Western populations. We examined the association between dietary inflammatory index (DII) scores and GDM in a case-control study conducted in Iran. METHODS: This study included 122 GDM cases and 266 controls hospitalized for acute non-neoplastic diseases. Cases were pregnant women aged 18-40 years, who visited major general hospitals in different regions of Tehran...
April 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29660080/contributions-of-ankle-knee-hip-and-trunk-muscle-function-to-gait-performance-in-people-with-multiple-sclerosis-a-cross-sectional-analysis
#10
Mark M Mañago, Jeffrey R Hebert, John Kittelson, Margaret Schenkman
Background: The relative importance of lower extremity and trunk muscle function to gait in people with multiple sclerosis (MS) is unknown. Objective: This study aimed to investigate the association of lower extremity and trunk muscle function with gait performance in people who have MS and mild to moderate disability. Design: This was a cross-sectional, observational study. Methods: Participants were people who had an Expanded Disability Status Scale score of ≤ 5...
April 6, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29655776/association-between-dietary-inflammatory-index-and-hodgkin-s-lymphoma-in-an-italian-case-control-study
#11
Nitin Shivappa, James R Hébert, Martina Taborelli, Antonella Zucchetto, Maurizio Montella, Massimo Libra, Carlo La Vecchia, Diego Serraino, Jerry Polesel
OBJECTIVES: The components of a diet can modulate inflammation and may have an effect on the development of Hodgkin's lymphoma (HL). Little is known about the inflammatory potential of diet in relation to HL. METHODS: Data from an Italian multicenter case-control study that was conducted between 1992 and 2008 were used to estimate the relation between a dietary inflammatory index (DII® ) and the risk of HL. The data included 179 cases with incident, histologically confirmed HL and 186 control cases who were hospitalized for acute non-neoplastic diseases...
February 12, 2018: Nutrition
https://www.readbyqxmd.com/read/29652371/highly-coherent-free-running-dual-comb-chip-platform
#12
Nicolas Bourbeau Hébert, David G Lancaster, Vincent Michaud-Belleau, George Y Chen, Jérôme Genest
We characterize the frequency noise performance of a free-running dual-comb source based on an erbium-doped glass chip running two adjacent mode-locked waveguide lasers. This compact laser platform, contained only in a 1.2 L volume, rejects common-mode environmental noise by 20 dB thanks to the proximity of the two laser cavities. Furthermore, it displays a remarkably low mutual frequency noise floor around 10  Hz2 /Hz, which is enabled by its large-mode-area waveguides and low Kerr nonlinearity. As a result, it reaches a free-running mutual coherence time of 1 s since mode-resolved dual-comb spectra are generated even on this time scale...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29651020/gfi1-facilitates-efficient-dna-repair-by-regulating-prmt1-dependent-methylation-of-mre11-and-53bp1
#13
Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Zhenbao Yu, Jonathan Boulais, Jordan Pinder, Daria Frank, Cyrus Khandanpour, Josée Hébert, Graham Dellaire, Jean-François Côté, Stéphane Richard, Alexandre Orthwein, Elliot Drobetsky, Tarik Möröy
GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GFI1 is required in T cells for the regulation of key DNA damage signaling and repair proteins. Specifically, GFI1 interacts with the arginine methyltransferase PRMT1 and its substrates MRE11 and 53BP1. We demonstrate that GFI1 enables PRMT1 to bind and methylate MRE11 and 53BP1, which is necessary for their function in the DNA damage response...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29649921/prostate-cancer-information-available-in-health-care-provider-offices-an-analysis-of-content-readability-and-cultural-sensitivity
#14
Seul Ki Choi, Jessica S Seel, Brooks Yelton, Susan E Steck, Douglas P McCormick, Johnny Payne, Anthony Minter, Elizabeth K Deutchki, James R Hébert, Daniela B Friedman
Prostate cancer (PrCA) is the most common cancer affecting men in the United States, and African American men have the highest incidence among men in the United States. Little is known about the PrCA-related educational materials being provided to patients in health-care settings. Content, readability, and cultural sensitivity of materials available in providers' practices in South Carolina were examined. A total of 44 educational materials about PrCA and associated sexual dysfunction was collected from 16 general and specialty practices...
April 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29649709/the-relationship-between-the-dietary-inflammatory-index-dii-%C3%A2-and-incident-depressive-symptoms-a-longitudinal-cohort-study
#15
Nitin Shivappa, James R Hébert, Nicola Veronese, Maria Gabriella Caruso, Maria Notarnicola, Stefania Maggi, Brendon Stubbs, Joseph Firth, Michele Fornaro, Marco Solmi
BACKGROUND: Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII® ), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults. METHODS: This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29629902/humanized-mouse-model-of-rasmussen-s-encephalitis-supports-the-immune-mediated-hypothesis
#16
Hania Kebir, Lionel Carmant, François Fontaine, Kathie Béland, Ciprian M Bosoi, Nathalie T Sanon, Jorge I Alvarez, Sébastien Desgent, Camille L Pittet, David Hébert, Marie-Josée Langlois, Rose-Marie Rébillard, Dang K Nguyen, Cécile Cieuta-Walti, Gregory L Holmes, Howard P Goodkin, John R Mytinger, Mary B Connolly, Alexandre Prat, Elie Haddad
Rasmussen's encephalitis (RE) is a chronic inflammatory brain disorder that causes frequent seizures and unilateral hemispheric atrophy with progressive neurological deficits. Hemispherectomy remains the only treatment that leads to seizure freedom for this refractory epileptic syndrome. The absence of an animal model of disease has been a major obstacle hampering the development of effective therapies. Here, we describe an experimental mouse model that shares several clinical and pathological features with the human disease...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29629806/comparative-effectiveness-of-transarterial-embolization-and-sorafenib-for-hepatocellular-carcinoma-a-population-based-study
#17
Sharon W Kwan, William P Harris, Laura S Gold, Paul L Hebert
OBJECTIVE: The purpose of this study was to compare the clinical effectiveness of embolization with that of sorafenib in the management of hepatocellular carcinoma as practiced in real-world settings. MATERIALS AND METHODS: This population-based observational study was conducted with the Surveillance, Epidemiology, and End Results-Medicare linked database. Patients 65 years old and older with a diagnosis of primary liver cancer between 2007 and 2011 who underwent embolization or sorafenib treatment were identified...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29626121/reproducibility-and-repeatability-of-semi-quantitative-18-f-fluorodihydrotestosterone-fdht-uptake-metrics-in-castration-resistant-prostate-cancer-metastases-a-prospective-multi-center-study
#18
Hebert Alberto Vargas, Gem M Kramer, Andrew M Scott, Andrew Weickhardt, Andreas A Meier, Nicole Parada, Bradley J Beattie, John L Humm, Kevin D Staton, Pat B Zanzonico, Serge K Lyashchenko, Jason S Lewis, Maqsood Yaqub, Ramon E Sosa, Alfons J van den Eertwegh, Ian D Davis, Uwe Ackermann, Kunthi Pathmaraj, Robert C Schuit, Albert D Windhorst, Sue Chua, Wolfgang A Weber, Steven M Larson, Howard I Scher, Adriaan A Lammertsma, Otto Hoekstra, Michael J Morris
18 F-fluorodihydrotestosterone (18 F-FDHT) is a radiolabeled analogue of the androgen receptor's primary ligand that is currently being credentialed as a biomarker for prognosis, response, and pharmacodynamic effects of new therapeutics. As part of the biomarker qualification process, we prospectively assessed its reproducibility and repeatability in men with metastatic castration-resistant prostate cancer (mCRPC). Methods: We conducted a prospective multi-institutional study of mCRPC patients undergoing two (test/re-test)18 F-FDHT PET/CT scans on two consecutive days...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29623142/chronic-pain-in-the-emergency-department-a-pilot-interdisciplinary-program-demonstrates-improvements-in-disability-psychosocial-function-and-healthcare-utilization
#19
Joshua A Rash, Patricia A Poulin, Yaadwinder Shergill, Heather Romanow, Jeffrey Freeman, Monica Taljaard, Guy Hebert, Ian G Stiell, Catherine E Smyth
Objective: To evaluate the feasibility of an individualized interdisciplinary chronic pain care plan as an intervention to reduce emergency department (ED) visits and improve clinical outcomes among patients who frequented the ED with concerns related to chronic pain. Methods: A prospective cohort design was used in an urban tertiary care hospital. As a pilot program, fourteen patients with chronic pain who frequented the ED (i.e., >12 ED visits within the last year, of which ≥50% were for chronic pain) received a rapid interdisciplinary assessment and individualized care plan that was uploaded to an electronic medical record system (EMR) accessible to the ED and patient's primary care provider...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29621713/analysis-of-endocrine-activity-in-drinking-water-surface-water-and-treated-wastewater-from-six-countries
#20
Frederic D L Leusch, Peta A Neale, Charlotte Arnal, Natalie H Aneck-Hahn, Patrick Balaguer, Auguste Bruchet, Beate I Escher, Mar Esperanza, Marina Grimaldi, Gaela Leroy, Marco Scheurer, Rita Schlichting, Merijn Schriks, Armelle Hebert
The aquatic environment can contain numerous micropollutants and there are concerns about endocrine activity in environmental waters and the potential impacts on human and ecosystem health. In this study a complementary chemical analysis and in vitro bioassay approach was applied to evaluate endocrine activity in treated wastewater, surface water and drinking water samples from six countries (Germany, Australia, France, South Africa, the Netherlands and Spain). The bioassay test battery included assays indicative of seven endocrine pathways, while 58 different chemicals, including pesticides, pharmaceuticals and industrial compounds, were analysed by targeted chemical analysis...
March 27, 2018: Water Research
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