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https://www.readbyqxmd.com/read/29782610/castration-induces-satellite-cell-activation-that-contributes-to-skeletal-muscle-maintenance
#1
Alanna Klose, Wenxuan Liu, Nicole D Paris, Sophie Forman, John J Krolewski, Kent L Nastiuk, Joe V Chakkalakal
Background: Sarcopenia, the age-related loss of skeletal muscle, is a side effect of androgen deprivation therapy (ADT) for prostate cancer patients. Resident stem cells of skeletal muscle, satellite cells (SCs), are an essential source of progenitors for the growth and regeneration of skeletal muscle. Decreased androgen signaling and deficits in the number and function of SCs are features of aging. Although androgen signaling is known to regulate skeletal muscle, the cellular basis for ADT-induced exacerbation of sarcopenia is unknown...
2018: JCSM rapid communications
https://www.readbyqxmd.com/read/29777438/no-evidence-of-binding-items-to-spatial-configuration-representations-in-visual-working-memory
#2
Rob Udale, Simon Farrell, Christopher Kent
When detecting changes in visual features (e.g., colour or shape), object locations, represented as points within a configuration, might also be automatically represented in working memory. If the configuration of a scene is represented automatically, the locations of individual items might form part of this representation, irrespective of their relevance to the task. Participants took part in a change-detection task in which they studied displays containing different sets of items (shapes, letters, objects), which varied in their task relevance...
May 17, 2018: Memory & Cognition
https://www.readbyqxmd.com/read/29771502/atmospheric-co2-enrichment-and-reactive-nitrogen-inputs-interactively-stimulate-soil-cation-losses-and-acidification
#3
Li Zhang, Yunpeng Qiu, Lei Cheng, Yi Wang, Lingli Liu, Cong Tu, Dan C Bowman, Kent O Burkey, Xinmin Bian, Weijian Zhang, Shuijin Hu
Reactive N inputs (Nr) may alleviate N-limitation of plant growth and are assumed to help sustain plant responses to the rising atmospheric CO2 (eCO2). However, Nr and eCO2 may elicit a cascade reaction that alters soil chemistry and nutrient availability, shifting the limiting factors of plant growth, particularly in acidic tropical and subtropical croplands with low organic matter and low nutrient cations. Yet, few have so far examined the interactive effects of Nr and eCO2 on the dynamics of soil cation nutrients and soil acidity...
May 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29768488/correction-clinicians-perspectives-on-incidentally-discovered-silent-brain-infarcts-a-qualitative-study
#4
Lester Y Leung, Paul K J Han, Christine Lundquist, Gene Weinstein, David E Thaler, David M Kent
[This corrects the article DOI: 10.1371/journal.pone.0194971.].
2018: PloS One
https://www.readbyqxmd.com/read/29767985/imaging-nanometer-phase-coexistence-at-defects-during-the-insulator-metal-phase-transformation-in-vo-2-thin-films-by-resonant-soft-x-ray-holography
#5
Luciana Vidas, Christian Guenther, Timothy Miller, Bastian Pfau, Daniel Perez, Elias Martinez, Michael Schneider, Erik Guehrs, Robert E Marvel, Kent Hallman, Richard F Haglund, Stefan Eisebitt, Simon Wall
We use resonant soft X-ray holography to image the insulator-metal phase transition in vanadium dioxide with element and polarization specificity and nanometer spatial resolution. We observe that nanoscale inhomogenity in the film results in spatial-dependent transition pathways between the insulating and metallic states. Additional nanoscale phases form in the vicinity of defects which are not apparent in the initial or final states of the system, which would be missed in area-integrated X-ray absorption measurements...
May 16, 2018: Nano Letters
https://www.readbyqxmd.com/read/29766842/continuous-low-dose-antibiotic-prophylaxis-to-prevent-urinary-tract-infection-in-adults-who-perform-clean-intermittent-self-catheterisation-the-antic-rct
#6
Robert Pickard, Thomas Chadwick, Yemi Oluboyede, Catherine Brennand, Alexander von Wilamowitz-Moellendorff, Doreen McClurg, Jennifer Wilkinson, Laura Ternent, Holly Fisher, Katherine Walton, Elaine McColl, Luke Vale, Ruth Wood, Mohamed Abdel-Fattah, Paul Hilton, Mandy Fader, Simon Harrison, James Larcombe, Paul Little, Anthony Timoney, James N'Dow, Heather Armstrong, Nicola Morris, Kerry Walker, Nikesh Thiruchelvam
BACKGROUND: People carrying out clean intermittent self-catheterisation (CISC) to empty their bladder often suffer repeated urinary tract infections (UTIs). Continuous once-daily, low-dose antibiotic treatment (antibiotic prophylaxis) is commonly advised but knowledge of its effectiveness is lacking. OBJECTIVE: To assess the benefit, harms and cost-effectiveness of antibiotic prophylaxis to prevent UTIs in people who perform CISC. DESIGN: Parallel-group, open-label, patient-randomised 12-month trial of allocated intervention with 3-monthly follow-up...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29766380/effects-of-race-are-rarely-included-in-clinical-prediction-models-for-cardiovascular-disease
#7
Jessica K Paulus, Benjamin S Wessler, Christine M Lundquist, David M Kent
No abstract text is available yet for this article.
May 15, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29766303/comparison-between-laparoscopic-and-open-hartmann-s-reversal-results-of-a-decade-long-multicenter-retrospective-study
#8
Nir Horesh, Yonatan Lessing, Yaron Rudnicki, Ilan Kent, Haguy Kammar, Almog Ben-Yaacov, Yael Dreznik, Shmuel Avital, Eli Mavor, Nir Wasserberg, Hanoch Kashtan, Joseph Klausner, Mordechai Gutman, Oded Zmora, Hagit Tulchinsky
BACKGROUND: Hartmann's reversal is a challenging surgical procedure with significant postoperative morbidity rates. Various surgical methods have been suggested to lower the risk of postoperative complications. In this study, we aimed to compare the postoperative results between open and laparoscopic techniques for Hartmann's reversal. METHODS: A retrospective study of all patients who underwent Hartmann's reversal in five centers in central Israel between January 2004 and June 2015 was conducted...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29762313/experiences-of-undergraduate-nursing-students-in-peer-assisted-learning-in-clinical-practice-a-qualitative-systematic-review
#9
Matthew C Carey, Bridie Kent, Jos M Latour
OBJECTIVES: The objective of this qualitative systematic review was to identify and synthesize the best available evidence on experiences of peer assisted learning (PAL) among student nurses in clinical practice so as to understand the value of PAL for this population. INTRODUCTION: Peer-assisted learning considers the benefits of peers working in collaboration and supporting each other in professional roles. This approach to facilitate learning is effective within universities, but there is limited exploration within the clinical practice environment...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761766/factors-associated-with-the-rapid-and-durable-decline-in-malaria-incidence-in-el-salvador-1980-2017
#10
Robert A Burton, José Eduardo Romero Chévez, Mauricio Sauerbrey, Caterina Guinovart, Angela Hartley, Geoffrey Kirkwood, Matthew Boslego, Mirna Elizabeth Gavidia, Jaime Enrique Alemán Escobar, Rachel Turkel, Richard W Steketee, Laurence Slutsker, Kammerle Schneider, Carlos C Kent Campbell
A decade after the Global Malaria Eradication Program, El Salvador had the highest burden of malaria in Mesoamerica, with approximately 20% due to Plasmodium falciparum . A resurgence of malaria in the 1970s led El Salvador to alter its national malaria control strategy. By 1995, El Salvador recorded its last autochthonous P. falciparum case with fewer than 20 Plasmodium vivax cases annually since 2011. By contrast, its immediate neighbors continue to have the highest incidences of malaria in the region. We reviewed and evaluated the policies and interventions implemented by the Salvadoran National Malaria Program that likely contributed to this progress toward malaria elimination...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29760442/cross-ancestry-genome-wide-association-analysis-of-corneal-thickness-strengthens-link-between-complex-and-mendelian-eye-diseases
#11
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29759500/antibacterial-envelope-is-associated-with-low-infection-rates-after-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-therapy-device-replacement-results-of-the-citadel-and-centurion-studies
#12
Charles A Henrikson, M Rizwan Sohail, Helbert Acosta, Eric E Johnson, Lawrence Rosenthal, Roman Pachulski, Dan Dan, Walter Paladino, Farhat S Khairallah, Kent Gleed, Ibrahim Hanna, Alan Cheng, Daniel R Lexcen, Grant R Simons
OBJECTIVES: This study sought to determine whether the nonabsorbable TYRX Antibacterial Envelope (TYRX) reduces major cardiovascular implantable electronic device (CIED) infections 12 months after implant. BACKGROUND: TYRX is a monofilament polypropylene mesh impregnated with minocycline and rifampin specifically designed to hold a CIED in place and elute antimicrobials over time. There are limited data on its ability to reduce CIED infections. METHODS: We prospectively enrolled patients who underwent generator replacement with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy device (CRT), treated with TYRX...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754597/re-wired-treatment-and-peer-support-for-men-who-have-sex-with-men-who-use-methamphetamine
#13
Kent Burgess, Garth Parkhill, Jeremy Wiggins, Simon Ruth, Mark Stoovè
Background This paper examines a methamphetamine treatment and peer support program for gay men and other men who have sex with men (MSM) who use methamphetamine. Australian MSM use illicit drugs including methamphetamine at significantly higher rates than the broader community.1,2 Methamphetamine rates are higher again amongst HIV positive MSM. Methamphetamine in the MSM community is associated with sexual activity and may be associated with psychosocial harms including risk of the transmission of HIV and sexually transmissible infections...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29753639/nrem-parasomnias-a-treatment-approach-based-upon-a-retrospective-case-series-of-512-patients
#14
Panagis Drakatos, Lucy Marples, Rexford Muza, Sean Higgins, Nadia Gildeh, Raluca Macavei, Eptehal M Dongol, Alexander Nesbitt, Ivana Rosenzweig, Elaine Lyons, Grainne d'Ancona, Joerg Steier, Adrian J Williams, Brian D Kent, Guy Leschziner
BACKGROUND: Non-REM parasomnias are not uncommon conditions in the general population. Current treatment options are based on small case series and reports. In this study, we aimed to present the clinical experience from a large cohort of patients. PATIENTS: Five hundred and twelve patients with Non-REM parasomnia or parasomnia overlap disorder (POD), who had undergone a video polysomnography and were exposed to treatment, were retrospectively identified. Treatment outcome was assessed based on patients' reports, and treatment approach on a locally accepted hierarchy of interventions...
April 10, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29752761/spatial-analysis-of-lipid-metabolites-and-expressed-genes-reveals-tissue-specific-heterogeneity-of-lipid-metabolism-in-high-and-low-oil-brassica-napus-l-seeds
#15
Shaoping Lu, Drew Sturtevant, Mina Aziz, Cheng Jin, Qing Li, Kent D Chapman, Liang Guo
Despite the importance of oilseeds to worldwide human nutrition, and more recently to the production of bio-based diesel fuels, the detailed mechanisms regulating seed oil biosynthesis remain partly understood, especially from a tissue-specific perspective. Here, we investigated the spatial distributions of lipid metabolites and transcripts involved in oil biosynthesis from seeds of two low-erucic acid genotypes of Brassica napus with high and low seed oil content. Integrated results from matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) of lipids in situ, lipidome profiling of extracts from seed tissues, and tissue-specific transcriptome analysis revealed complex spatial distribution patterns of lipids and transcripts...
May 11, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29752462/the-role-of-radiography-and-mri-for-eligibility-assessment-in-dmoad-trials-of-knee-oa
#16
REVIEW
Frank W Roemer, C Kent Kwoh, Daichi Hayashi, David T Felson, Ali Guermazi
Currently, no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Past clinical trials have failed for several reasons, including the commonly applied definition of eligibility based on radiographic assessment of joint structure. In the context of precision medicine, finding the appropriate patient for a specific treatment approach will be of increasing relevance. Phenotypic stratification by use of imaging at the time of determining eligibility for clinical trials will be paramount and cannot be achieved using radiography alone...
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752053/anterior-laxity-lateral-tibial-slope-and-in-situ-acl-force-differentiate-knees-exhibiting-distinct-patterns-of-motion-during-a-pivoting-event-a-human-cadaveric-study
#17
Robert N Kent, Mark J Amirtharaj, Brendan M Hardy, Andrew D Pearle, Thomas L Wickiewicz, Carl W Imhauser
Knee instability following anterior cruciate ligament (ACL) rupture compromises function and increases risk of injury to the cartilage and menisci. To understand the biomechanical function of the ACL, previous studies have primarily reported the net change in tibial position in response to multiplanar torques, which generate knee instability. In contrast, we retrospectively analyzed a cohort of 13 consecutively tested cadaveric knees and found distinct motion patterns, defined as the motion of the tibia as it translates and rotates from its unloaded, initial position to its loaded, final position...
April 11, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29750857/residue-specific-dynamics-and-local-environmental-change-in-a%C3%AE-40-oligomer-and-fibril-formation
#18
Haiyang Liu, Clifford Morris, Richard Lantz, Thomas W Kent, Esmail A Elbassal, Ewa P Wojcikiewicz, Deguo Du
Elucidation of local dynamics of protein aggregation is crucial for understanding the mechanistic details of protein amyloidogenesis. Herein, we studied the residue-specific dynamics and the local environmental changes of Aβ40 along the course of aggregation, using p-cyanophenylalanine (PheCN) as a fluorescent and vibrational probe. Our results show that the PheCN residues studied at various positions all exhibit immediate decay of fluorescence intensity, indicating a relatively synergistic process in the early oligomer formation...
May 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29750551/where-are-they-now-assessing-if-persons-returned-to-hiv-care-following-loss-to-follow-up-by-public-health-case-workers-were-engaged-in-care-in-follow-up-years
#19
Chi-Chi N Udeagu, Sharmila Shah, Kavita Misra, Kent A Sepkowitz, Sarah L Braunstein
We examined care engagement and viral suppression (VS) over a 1- to 5-year period among persons re-engaged in HIV care using retrospective cohort study and longitudinal follow-up. The population comprised five cohorts of persons re-engaged in care from 2009 to 2013. We used surveillance data [CD4 T cell count or HIV viral load (VL) RNA] to measure four outcomes 1-5 years post-care engagement. Engagement-in-care indicated persons with laboratory reports in each follow-up year. Continuous engagement or sustained engagement, respectively, included persons with ≥1 or ≥2 (separated by 90 days) CD4 or VL reports in each follow-up year...
May 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29750252/whole-exome-sequencing-of-an-exceptional-longevity-cohort
#20
Haakon B Nygaard, E Zeynep Erson-Omay, Xiujuan Wu, Brianne A Kent, Cecily Q Bernales, Daniel M Evans, Matthew J Farrer, Carles Vilariño-Güell, Stephen M Strittmatter
Centenarians represent a unique cohort to study the genetic basis for longevity and factors determining the risk of neurodegenerative disorders, including Alzheimer's disease (AD). The estimated genetic contribution to longevity is highest in centenarians and supercententenarians, but few genetic variants have been shown to clearly impact this phenotype. While the genetic risk for AD and other dementias is now well understood, the frequency of known dementia risk variants in centenarians is not fully characterized...
May 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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