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https://www.readbyqxmd.com/read/29148383/porcine-astrovirus-type-3-in-central-nervous-system-of-swine-with-polioencephalomyelitis
#1
Bailey Arruda, Paulo Arruda, Melissa Hensch, Qi Chen, Ying Zheng, Chenghuai Yang, Igor Renan Honorato Gatto, Franco Matias Ferreyra, Phil Gauger, Kent Schwartz, Laura Bradner, Karen Harmon, Ben Hause, Ganwu Li
Using next-generation sequencing, we identified and genetically characterized a porcine astrovirus type 3 strain found in tissues from the central nervous system of 1 piglet and 3 sows with neurologic signs and nonsuppurative polioencephalomyelitis. Further studies are needed to understand the potential for cross-species transmission and clinical impact.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29148264/negative-symptoms-in-first-episode-psychosis-clinical-correlates-and-1-year-follow-up-outcomes-in-london-early-intervention-services
#2
Aikaterini Rammou, Helen L Fisher, Sonia Johnson, Barnaby Major, Nikola Rahaman, Nick Chamberlain-Kent, James M Stone
AIM: Negative symptoms (NS) have been associated with poor outcome and remain difficult to treat in patients with psychosis. This study examined the association of NS with clinical features at first presentation to mental health services for psychosis and with outcomes at 1-year follow-up. METHODS: Clinical data were utilized from five London Early Intervention Services (EIS) included in the MiData audit database. The sample comprised 484 first-episode psychosis patients with complete Positive and Negative Syndrome Scale data at baseline and 1-year follow-up...
November 16, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29146299/functional-connectivity-during-affective-mentalizing-in-criminal-offenders-with-psychotic-disorders-associations-with-clinical-symptoms
#3
Carla L Harenski, Vince D Calhoun, Juan R Bustillo, Brian W Haas, Jean Decety, Keith A Harenski, Michael F Caldwell, Gregory J Van Rybroek, Michael Koenigs, David M Thornton, Kent A Kiehl
Psychotic disorders are associated with neurobehavioral impairments in mental state attribution (mentalizing). These impairments are most severe in psychotic patients with elevated symptom levels, particularly negative and cognitive symptoms. There have been few studies of functional connectivity related to mentalizing in psychotic disorders and associations with symptoms. We conducted a functional MRI study of affective mentalizing in individuals with psychotic disorders and varying symptom levels (positive, negative, cognitive)...
November 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29144450/corrigendum-high-throughput-discovery-of-novel-developmental-phenotypes
#4
Mary E Dickinson, Ann M Flenniken, Xiao Ji, Lydia Teboul, Michael D Wong, Jacqueline K White, Terrence F Meehan, Wolfgang J Weninger, Henrik Westerberg, Hibret Adissu, Candice N Baker, Lynette Bower, James M Brown, L Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J Daly, James M Denegre, Brendan Doe, Mary E Dolan, Sarah M Edie Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R Horner, Chih-Wei Hsu, Sara J Johnson, Sowmya Kalaga, Lance C Keith, Louise Lanoue, Thomas N Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L McElwee, Susan Newbigging Lauryl M J Nutter, Kevin A Peterson, Ramiro Ramirez-Solis, Douglas J Rowland, Edward Ryder, Kaitlin E Samocha, John R Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B West, Leeyean Wong, Atsushi Yoshiki, Wolfgang Wurst, Daniel G MacArthur, Glauco P Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C Skarnes, Monica J Justice, Helen E Parkinson, Mark Moore, Sara Wells, Robert E Braun, Karen L Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R Mark Henkelman, Steve D M Brown, David J Adams, K C Kent Lloyd, Colin McKerlie, Arthur L Beaudet, Maja Bućan Stephen A Murray
This corrects the article DOI: 10.1038/nature19356.
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29143540/association-between-nutrition-resource-stress-and-dietary-consumption-results-from-a-u-s-nationally-representative-survey
#5
Emily Grenen, Erin E Kent, Erin Hennessy, Jada G Hamilton, Rebecca A Ferrer
BACKGROUND: There is little research on how affective reactions (e.g., stress) to perceptions of nutritious food accessibility contribute to dietary behaviors. AIMS: This study explores whether stress associated with limited access to nutritious foods-termed nutrition resource stress (NRS)-contributes to diet outcomes, and whether these associations are mediated by health-related self-efficacy. METHOD: Using data from the cross-sectional National Cancer Institute's Health Information National Trends Survey, analyses were conducted to examine whether reported NRS was associated with specific dietary behaviors (i...
November 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29142941/the-longitudinal-study-of-liver-cysts-in%C3%A2-patients-with-autosomal-dominant-polycystic-kidney-disease-and-polycystic-liver-disease
#6
Ryo Matsuura, Kenjiro Honda, Yoshifumi Hamasaki, Kent Doi, Eisei Noiri, Masaomi Nangaku
Introduction: Although polycystic liver disease (PCLD) is one of the extrarenal complications in patients with autosomal dominant polycystic kidney disease (ADPKD), longitudinal changes and the association with total liver volume (TLV) have not been clearly elucidated yet. Methods: Patients with ADPKD were chosen who underwent computed tomography or magnetic resonance imaging twice or more during August 2003 through December 2015. TLV, each cyst volume, and the proportion of parenchyma were measured...
January 2017: KI Reports
https://www.readbyqxmd.com/read/29141625/microrna-profiling-of-dogs-with-transitional-cell-carcinoma-of-the-bladder-using-blood-and-urine-samples
#7
Michael S Kent, Allison Zwingenberger, Jodi L Westropp, Laura E Barrett, Blythe P Durbin-Johnson, Paramita Ghosh, Ruth L Vinall
BACKGROUND: Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC which could be fatal. The development of a non-invasive clinical test for TCC could dramatically reduce mortality. To determine whether microRNAs (miRNAs) can be used as non-invasive diagnostic biomarkers, we assessed miRNA expression in blood and/or urine from dogs with clinically normal bladders (n = 28), LUTD (n = 25), and TCC (n = 17)...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29138276/metabolic-reprogramming-ensures-cancer-cell-survival-despite-oncogenic-signaling-blockade
#8
Hui-Wen Lue, Jennifer Podolak, Kevin Kolahi, Larry Cheng, Soumya Rao, Devin Garg, Chang-Hui Xue, Juha K Rantala, Jeffrey W Tyner, Kent L Thornburg, Ann Martinez-Acevedo, Jen-Jane Liu, Christopher L Amling, Charles Truillet, Sharon M Louie, Kimberly E Anderson, Michael J Evans, Valerie B O'Donnell, Daniel K Nomura, Justin M Drake, Anna Ritz, George V Thomas
There is limited knowledge about the metabolic reprogramming induced by cancer therapies and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K-AKT-mTOR signaling markedly decreased glycolysis and restrained tumor growth, these signaling and metabolic restrictions triggered autophagy, which supplied the metabolites required for the maintenance of mitochondrial respiration and redox homeostasis. Specifically, we found that survival of cancer cells was critically dependent on phospholipase A2 (PLA2) to mobilize lysophospholipids and free fatty acids to sustain fatty acid oxidation and oxidative phosphorylation...
November 14, 2017: Genes & Development
https://www.readbyqxmd.com/read/29136434/change-in-testing-awareness-of-hemoglobin-a1c-result-and-glycemic-control-in-us-adults-2007-2014
#9
Saeid Shahraz, Anastassios G Pittas, Mojdeh Saadati, Cindy P Thomas, Christine M Lundquist, David M Kent
No abstract text is available yet for this article.
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29134961/the-impact-of-combinations-of-alcohol-nicotine-and-cannabis-on-dynamic-brain-connectivity
#10
Victor M Vergara, Barbara J Weiland, Kent Hutchison, Vince D Calhoun
Alcohol, nicotine and cannabis are among the most commonly used drugs. A prolonged and combined use of these substances can alter normal brain wiring in different ways depending on the consumed cocktail mixture. Brain connectivity alterations and their change with time can be assessed using functional magnetic resonance imaging (fMRI) because of its spatial and temporal content. Here, we estimated dynamic functional network connectivity (dFNC) as derived from fMRI data to investigate the effects of single or combined use of alcohol, nicotine and cannabis...
November 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29134728/recent-advances-in-veterinary-radiation-oncology
#11
EDITORIAL
Michael S Kent, Michelle M Turek, John Farrelly
No abstract text is available yet for this article.
November 13, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29134613/dfd-01-reduces-transepidermal-water-loss-and-improves-skin-hydration-and-flexibility
#12
J Mark Jackson, Gary L Grove, Kent Allenby, Tim Houser
INTRODUCTION: In plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0.05%) is a formulation composed of a topical steroid in an emollient-like vehicle that enhances penetration to the target site of inflammation in the skin. The aim of this study was to assess the effect of DFD-01 and its vehicle on skin hydration and barrier function in compromised skin and to evaluate its effect on flexibility in healthy skin...
November 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29132832/the-proposed-concordance-statistic-for-benefit-provided-a-useful-metric-when-modeling-heterogeneous-treatment-effects
#13
David van Klaveren, Ewout W Steyerberg, Patrick W Serruys, David M Kent
OBJECTIVES: Clinical prediction models that support treatment decisions are usually evaluated for their ability to predict the risk of an outcome rather than treatment benefit - the difference between outcome risk with versus without therapy. We aimed to define performance metrics for a model's ability to predict treatment benefit. STUDY DESIGN AND SETTING: We analyzed data of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial, and of 3 recombinant tissue plasminogen activator trials...
November 10, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29132346/less-healthy-breakfast-cereals-are-promoted-more-frequently-in-large-supermarket-chains-in-canada
#14
Monique Potvin Kent, Erika Rudnicki, Crystal Usher
BACKGROUND: The majority of food expenditures are made in supermarkets and this environment influences our purchasing and food intake. Breakfast cereals are frequently marketed as healthy food choices. The objective of this study was to examine the frequency of in-store promotions for cold breakfast cereals in Canadian supermarkets and to determine whether healthier or less healthy breakfast cereals are promoted more frequently. METHODS: Data was collected once per week over a four-week period from a convenience sample of the five largest Canadian supermarkets in the Ottawa/Gatineau area...
November 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29131587/cell-migration-and-bone-formation-from-mesenchymal-stem-cell-spheroids-in-alginate-hydrogels-are-regulated-by-adhesive-ligand-density
#15
Steve S Ho, Andrew T Keown, Bennett Addison, J Kent Leach
The adhesion and migration of cells entrapped in engineered materials is regulated by available adhesive ligands. Although mesenchymal stem cell (MSC) spheroids injected into damaged tissues promote repair, their transplantation in biomaterials which regulate cell migration from the aggregate may further enhance their therapeutic potential. Alginate hydrogels were modified with Arginine-Glycine-Aspartic acid (RGD) at increasing concentrations, and osteogenically induced human MSC spheroids were entrapped to assess cell migration, survival, and differentiation...
November 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29131514/quantitative-trait-loci-associated-with-soybean-seed-weight-and-composition-under-different-phosphorus-levels
#16
Gokhan Hacisalihoglu, Amy L Burton, Jeffery L Gustin, Selim Eker, Safiye Asikli, Elif Hakli Heybet, Levent Ozturk, Ismail Cakmak, Atilla Yazici, Kent O Burkey, James Orf, A Mark Settles
Seed size and composition are important traits in food crops and can be affected by nutrient availability in the soil. Phosphorus (P) is a non-renewable, essential macronutrient, and P deficiency limits soybean (Glycine max) yield and quality. To investigate the associations of seed traits in low- and high-P environments, soybean recombinant inbred lines (RILs) from the cross of cultivars Fiskeby III and Mandarin (Ottawa) were grown under contrasting P availability environments. Traits including individual seed weight, seed number, and intact mature pod weight were significantly affected by soil P levels and showed transgressive segregation among the RILs...
November 13, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29131394/shaken-or-stirred-evaluating-the-combination-of-budesonide-surfactant-for-survival-free-of-bronchopulmonary-dysplasia
#17
Kent Willis, Mark Weems
No abstract text is available yet for this article.
November 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29131227/controlling-electron-and-energy-transfer-paths-by-selective-excitation-in-a-zinc-porphyrin-bodipy-c60-multi-modular-triad
#18
Christopher O Obondi, Gary N Lim, Priscilla Martinez, Varghese Swamy, Francis D'Souza
A multi-modular donor-acceptor triad composed of zinc porphyrin, BF2-chelated dipyrromethene (BODIPY), and C60 was newly synthesized, with the BODIPY entity at the central position. Using absorbance and emission spectral, electrochemical redox, and computational optimization results, energy level diagrams for the ZnP-BODIPY dyad and ZnP-BODIPY-C60 triad were constructed to envision the different photochemical events upon selective excitation of the BODIPY and ZnP entities. By transient absorption spectral studies covering a wide femtosecond-to-millisecond time scale, evidence for the different photochemical events and their kinetic information was secured...
November 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29130869/effects-of-a-museum-based-social-prescription-intervention-on-quantitative-measures-of-psychological-wellbeing-in-older-adults
#19
Linda J Thomson, Bridget Lockyer, Paul M Camic, Helen J Chatterjee
AIMS: To assess psychological wellbeing in a novel social prescription intervention for older adults called Museums on Prescription and to explore the extent of change over time in six self-rated emotions ('absorbed', 'active', 'cheerful', 'encouraged', 'enlightened' and 'inspired'). METHODS: Participants ( n = 115) aged 65-94 years were referred to museum-based programmes comprising 10 weekly sessions, by healthcare and third sector organisations using inclusion criteria (e...
November 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/29130147/callous-unemotional-traits-modulate-brain-drug-craving-response-in-high-risk-young-offenders
#20
Gina M Vincent, Lora M Cope, Jean King, Prashanth Nyalakanti, Kent A Kiehl
Adults with psychopathy have a high propensity for substance abuse, generally starting from a young age. This investigation tested hypotheses about differences in the neural responses associated with drug craving among high-risk young offenders with histories of abuse of stimulants and other drugs as a function of psychopathic traits. Fifty-four male adolescents (44 with a history of stimulant abuse and 10 controls) incarcerated at a maximum-security facility (M age = 17.08 years) completed a drug-cue exposure task while brain hemodynamic activity was monitored using functional magnetic resonance imaging (fMRI) with a mobile MRI scanner stationed at the facility...
November 13, 2017: Journal of Abnormal Child Psychology
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