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https://www.readbyqxmd.com/read/28750477/anti-pcsk9-antibodies-for-hypercholesterolaemia-overview-of-clinical-data-and-implications-for-primary-care
#1
REVIEW
Olivier S Descamps, Uwe Fraass, Ricardo Dent, Winfried März, Ioanna Gouni-Berthold
OBJECTIVES: To put data from our recent systematic review of phase 3 studies of anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies into the context of clinical practice. METHODS: Data from studies previously identified by a systematic review of phase 3 studies of alirocumab and evolocumab and additional references from non-systematic literature searches were used. We evaluated the hypothetical cardiovascular (CV) benefit in cases of typical patients in whom anti-PCSK9 antibodies may be recommended, using preliminary major CV event (CVE) rates from long-term clinical trials of anti-PCSK9 antibodies and from extrapolations derived from correlation between low-density lipoprotein cholesterol (LDL-C) reduction and CV benefit with other lipid-lowering therapies (LLTs)...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750345/are-brief-alcohol-interventions-targeting-alcohol-use-efficacious-in-military-and-veteran-populations-a-meta-analysis
#2
REVIEW
A M Doherty, C Mason, N T Fear, R Rona, N Greenberg, L Goodwin
BACKGROUND: Rates of hazardous and harm-related drinking are higher in the military and veteran populations compared to the general population. Brief alcohol interventions (BAIs) targeting alcohol use appear to reduce harmful drinking in the general population. However, less is known about the efficacy of BAIs targeting alcohol in military and veteran populations. METHODS: A systematic review and meta-analysis was conducted to assess the type and efficacy of BAIs used to reduce alcohol use in military and veteran populations conducted from 2000 onwards...
July 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28750310/manual-therapy-exercise-therapy-or-combined-treatment-in-the-management-of-adult-neck-pain-a-systematic-review-and-meta-analysis
#3
REVIEW
Ken Fredin, Håvard Lorås
BACKGROUND: Neck pain is a common and often disabling musculoskeletal condition. Two therapies frequently prescribed for its management are manual therapy (MT) and exercise therapy (ET), and combining these treatment approaches are common. OBJECTIVE: To assess whether or not combined treatment consisting of MT and ET is more effective than either therapy alone in relieving pain and improving function in adult patients with grade I-II neck pain. DESIGN: Systematic review with meta-analysis...
July 21, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28750264/the-perpetrators-of-medical-child-abuse-munchausen-syndrome-by-proxy-a-systematic-review-of-796-cases
#4
REVIEW
Gregory Yates, Christopher Bass
INTRODUCTION: Little is known about the perpetrators of medical child abuse (MCA) which is often described as "Munchausen's syndrome by proxy" or "factitious disorder imposed on another". The demographic and clinical characteristics of these abusers have yet to be described in a sufficiently large sample. We aimed to address this issue through a systematic review of case reports and series in the professional literature. METHOD: A systematic search for case reports and series published since 1965 was undertaken using MEDLINE, Web of Science and EMBASE...
July 24, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28750245/antecedents-and-outcomes-of-nurses-rest-break-organization-a-scoping-review
#5
REVIEW
Johannes Wendsche, Argang Ghadiri, Amelie Bengsch, Jürgen Wegge
OBJECTIVES: To prevent an accumulation of strain during work and to reduce error risk, many countries have made rest breaks mandatory. In the nursing literature, insufficient rest break organization is often reported. However, the outcomes of nurses' rest break organization and its anteceding factors are less clear. DATA SOURCES: We searched for academic literature on nurses' rest break organization in electronic databases (PubMed, Medline, PsycArticles, PsycINFO, CINAHL)...
July 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28750220/effects-of-medicinal-food-plants-on-impaired-glucose-tolerance-a-systematic-review-of-randomized-controlled-trials
#6
REVIEW
A Demmers, H Korthout, F S van Etten-Jamaludin, F Kortekaas, J M Maaskant
BACKGROUND: The objective of this systematic review was to assess available scientific data on the efficacy and safety of medicinal food plants for the treatment of impaired glucose tolerance. METHODS: We included randomized controlled trials (RCTs) with a minimum follow-up period of 6weeks. The diagnosis was determined by fasting plasma glucose values after two-hour oral glucose tolerance testing (OGTT). Two authors independently extracted data and evaluated bias...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28750216/efficacy-of-low-carbohydrate-diet-for-type-2-diabetes-mellitus-management-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Yan Meng, Hao Bai, Shijun Wang, Zhaoping Li, Qian Wang, Liyong Chen
AIMS: The objective of this systematic review and meta-analysis is to assess the efficacy of Low Carbohydrate Diet (LCD) compared with a normal or high carbohydrate diet in patients with type 2 diabetes. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library database for randomized controlled trials. Researches which reported the change in weight loss, blood glucose, and blood lipid levels were included. RESULTS: A total of 9 studies with 734 patients with diabetes were included...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28750208/understanding-low-levels-of-physical-activity-in-people-with-intellectual-disabilities-a-systematic-review-to-identify-barriers-and-facilitators
#8
REVIEW
L W M Bossink, Annette Aj van der Putten, Carla Vlaskamp
BACKGROUND: People with intellectual disabilities (ID) undertake extremely low levels of physical activity. AIMS: To enhance understanding concerning low levels of physical activity in people with ID, this study has three aims: (1) to identify barriers to and facilitators of physical activity in people with ID; (2) to examine differences in barriers and facilitators between levels of ID (mild, moderate, severe, and profound); (3) to examine differences in barriers and facilitators between various stakeholder groups...
July 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28750173/the-experiences-of-parenting-a-child-with-an-acquired-brain-injury-a-meta-synthesis-of-the-qualitative-literature
#9
Emma Tyerman, Fiona J R Eccles, Victoria Gray
OBJECTIVE: To systematically review and then synthesize the qualitative literature on the experience of parenting a child with an acquired brain injury (ABI). DESIGN: Systematic literature review and meta-synthesis Methods. A systematic search of the literature was conducted in four databases. Papers which met the inclusion criterion were assessed for quality using the Critical Skills Appraisal Programme (CASP) tool and then synthesized according to Noblit and Hare's (1988) guidelines for meta-ethnography...
July 27, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28750145/severity-assessments-used-for-inclusion-criteria-and-baseline-severity-evaluation-in-atopic-dermatitis-clinical-trials-a-systematic-review
#10
Rishi Chopra, Paras P Vakharia, Eric L Simpson, Amy S Paller, Jonathan I Silverberg
BACKGROUND: Numerous inclusion criteria and baseline severity assessments are used in clinical trials of atopic dermatitis (AD), which may limit comparison of results. OBJECTIVE: We sought to characterize the inclusion criteria and baseline severity assessments used in randomized controlled trials (RCT) of AD internationally. METHODS: We performed a systematic review of RCT with a pharmacological intervention from 2007-2016. Cochrane Library, EMBASE, GREAT, LILACS, MEDLINE and Scopus were searched...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28750095/serum-tumor-associated-autoantibodies-as-diagnostic-biomarkers-for-lung-cancer-a-systematic-review-and-meta-analysis
#11
Zhen-Ming Tang, Zhou-Gui Ling, Chun-Mei Wang, Yan-Bin Wu, Jin-Liang Kong
OBJECTIVE: We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC). METHODS: We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test. RESULTS: The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28749983/how-does-mandibular-advancement-with-or-without-maxillary-procedures-affect-pharyngeal-airways-an-overview-of-systematic-reviews
#12
Su Keng Tan, Wai Keung Leung, Alexander Tin Hong Tang, Roger A Zwahlen
BACKGROUND: Mandibular advancement surgery may positively affect pharyngeal airways and therefore potentially beneficial to obstructive sleep apnea (OSA). OBJECTIVE: To collect evidence from published systematic reviews that have evaluated pharyngeal airway changes related to mandibular advancement with or without maxillary procedures. METHODOLOGY: PubMed, EMBASE, Web of Science, and Cochrane Library were searched without limiting language or timeline...
2017: PloS One
https://www.readbyqxmd.com/read/28749981/a-systematic-review-and-meta-analysis-on-herpes-zoster-and-the-risk-of-cardiac-and-cerebrovascular-events
#13
Nathaniel Erskine, Hoang Tran, Leonard Levin, Christine Ulbricht, Joyce Fingeroth, Catarina Kiefe, Robert J Goldberg, Sonal Singh
BACKGROUND: Patients who develop herpes zoster or herpes zoster ophthalmicus may be at risk for cerebrovascular and cardiac complications. We systematically reviewed the published literature to determine the association between herpes zoster and its subtypes with the occurrence of cerebrovascular and cardiac events. METHODS/RESULTS: Systematic searches of PubMed (MEDLINE), SCOPUS (Embase) and Google Scholar were performed in December 2016. Eligible studies were cohort, case-control, and self-controlled case-series examining the association between herpes zoster or subtypes of herpes zoster with the occurrence of cerebrovascular and cardiac events including stroke, transient ischemic attack, coronary heart disease, and myocardial infarction...
2017: PloS One
https://www.readbyqxmd.com/read/28749971/pediatric-cancer-risk-in-association-with-birth-defects-a-systematic-review
#14
Kimberly J Johnson, Jong Min Lee, Kazi Ahsan, Hannah Padda, Qianxi Feng, Sonia Partap, Susan A Fowler, Todd E Druley
BACKGROUND: Many epidemiological studies have examined associations between birth defects (BDs) and pediatric malignancy over the past several decades. Our objective was to conduct a systematic literature review of studies reporting on this association. METHODS: We used librarian-designed searches of the PubMed Medline and Embase databases to identify primary research articles on pediatric neoplasms and BDs. English language articles from PubMed and Embase up to 10/12/2015, and in PubMed up to 5/12/2017 following an updated search, were eligible for inclusion if they reported primary epidemiological research results on associations between BDs and pediatric malignancies...
2017: PloS One
https://www.readbyqxmd.com/read/28749970/effectiveness-of-physical-activity-on-patients-with-depression-and-parkinson-s-disease-a-systematic-review
#15
Pei-Ling Wu, Megan Lee, Tzu-Ting Huang
AIM: In this paper we aimed to systematically review the literature on physical activity's effect on depressive symptoms in Parkinson disease. BACKGROUND: Depression is a common symptom of Parkinson's disease and is associated with increased disability, rapid progression of motor symptoms, mortality, and adverse effects on Quality of Life. DESIGN: A systematic review of primary research was undertaken and conducted according to the Preferred Reporting Items for Systematic Reviews...
2017: PloS One
https://www.readbyqxmd.com/read/28749877/sucrose-as-analgesia-in-neonates-undergoing-painful-procedures
#16
Erin Matsuda
Editor's note: This is a summary of a nursing care-related systematic review from the Cochrane Library. For more information, see http://nursingcare.cochrane.org.
August 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28749855/outcomes-of-patient-and-family-centered-care-interventions-in-the-icu-a-systematic-review-and-meta-analysis
#17
Michael J Goldfarb, Lior Bibas, Virginia Bartlett, Heather Jones, Naureen Khan
OBJECTIVE: To determine whether patient- and family-centered care interventions in the ICU improve outcomes. DATA SOURCES: We searched MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library databases from inception until December 1, 2016. STUDY SELECTION: We included articles involving patient- and family-centered care interventions and quantitative, patient- and family-important outcomes in adult ICUs. DATA EXTRACTION: We extracted the author, year of publication, study design, population, setting, primary domain investigated, intervention, and outcomes...
July 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28749769/a-systematic-review-and-meta-analysis-of-practices-exposing-humans-to-avian-influenza-viruses-their-prevalence-and-rationale
#18
Guillaume Fournié, Erling Høg, Tony Barnett, Dirk U Pfeiffer, Punam Mangtani
Almost all human infections by avian influenza viruses (AIVs) are transmitted from poultry. A systematic review was conducted to identify practices associated with human infections, their prevalence, and rationale. Observational studies were identified through database searches. Meta-analysis produced combined odds ratio estimates. The prevalence of practices and rationales for their adoptions were reported. Of the 48,217 records initially identified, 65 articles were included. Direct and indirect exposures to poultry were associated with infection for all investigated viral subtypes and settings...
May 15, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28749768/evidence-based-guidelines-for-screening-and-management-of-strongyloidiasis-in-non-endemic-countries
#19
Ana Requena-Méndez, Dora Buonfrate, Joan Gomez-Junyent, Lorenzo Zammarchi, Zeno Bisoffi, José Muñoz
Strongyloidiasis is an intestinal parasitic infection becoming increasingly important outside endemic areas, not only because of the high prevalence found in migrant populations, but also because immunosuppressed patients may suffer a potentially fatal disseminated disease. The aim of these guidelines is to provide evidence-based guidance for screening and treatment of strongyloidiasis in non-endemic areas. A panel of experts focused on three main clinical questions (who should be screened and how, how to treat), and reviewed pertinent literature available in international databases of medical literature and in documents released by relevant organizations/societies...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28749700/radiographic-diagnosis-of-root-fractures-a-systematic-review-meta-analyses-and-sources-of-heterogeneity
#20
Fernanda Cristina Sales Salineiro, Solange Kobayashi-Velasco, Mariana Minatel Braga, Marcelo Gusmão Paraiso Cavalcanti
OBJECTIVE: Many studies to evaluate the accuracy of root fracture diagnosis have been conducted. However, there is a scarcity of studies to assess the quality and the sources of heterogeneity in the literature. For this reason, the aim of this study was to conduct systematic reviews and meta-analyses to summarize the available evidence on detection of root fractures by CBCT and PR images and the interference of artifact by investigating possible sources of heterogeneity. METHODS: Studies reporting root fracture detection, from January 2010 to February 2016, were selected...
July 27, 2017: Dento Maxillo Facial Radiology
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