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systematic reviews

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https://www.readbyqxmd.com/read/29668073/sequential-systematic-anti-mold-prophylaxis-with-micafungin-and-voriconazole-results-in-very-low-incidence-of-invasive-mold-infections-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#1
Claudia Rosillo, Ana Maria Avila, Yao-Ting Huang, Sean Devlin, Christina Cho, Juan Montoro, Molly A Maloy, Genovefa A Papanicolaou, Pere Barba, Miguel-Angel Perales
BACKGROUND AND OBJECTIVES: Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk for invasive mold infections (IMI). The goal of the study is to describe the incidence and outcome of IMI in patients after allo-HSCT in a large cohort of patients receiving anti-mold prophylaxis. METHODS: We conducted a retrospective review of 988 consecutive adults who underwent allo-HSCT in our center from 2008 through 2014. Standard prophylaxis consisted of micafungin 150mg IV daily from admission to day +7 +/- 3 followed by voriconazole until day +75 to +100...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667936/automated-algorithms-for-detecting-sleep-period-time-using-a-multi-sensor-pattern-recognition-activity-monitor-from-24-h-free-living-data-in-older-adults
#2
Veronica Cabanas-Sanchez, Sara Higueras-Fresnillo, Miguel Ángel De La Camara, Oscar L Veiga, David Martinez-Gomez
The aims of the present study were: (i) to develop automated algorithms to identify the sleep period time in 24-h data from the Intelligent Device for Energy Expenditure and Activity (IDEEA) in older adults, and (ii) to analyze the agreement of these algorithms to identify the sleep period time as compared to self-reported data and expert visual analysis of accelerometer raw data.
 Approach. This study comprised 50 participants, aged 65 to 85 years. Fourteen automated algorithms were developed. Participants reported their bedtime and wake time in the days wearing the device...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667892/ct-colonography-performance-for-the-detection-of-polyps-and-cancer-in-adults-%C3%A2-65-years-old-systematic-review-and-meta-analysis
#3
Perry J Pickhardt, Loredana Correale, Silvia Delsanto, Daniele Regge, Cesare Hassan
OBJECTIVE: We sought to perform a systematic review and meta-analysis of published CT colonography (CTC) studies assessing lesion detection in senior-age (≥ 65 years old) cohorts. MATERIALS AND METHODS: We conducted a systematic review of CTC studies published between January 1994 and August 2017 containing data on senior-age adults. The primary endpoint was the CTC-positive rate for large colorectal polyps (≥ 10 mm) and masses. Secondary endpoints included lesions ≥ 6 mm, proven advanced neoplasia, and colorectal cancer (CRC)...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667863/leo-kanner-and-autism-a-75-year-perspective
#4
James Harris
In 1943, Leo Kanner published the first systematic description of early infantile autism. He concluded that this was a neurodevelopmental disorder and that 'these children have come into the world with an innate inability to form the usual, biologically provided contact with people'. Moreover, his astute descriptions of parental behavior in his first publications were prescient and underlie later recognition of the importance of genetics. Our understanding has grown over the ensuing years with revisions in diagnostic classification, recognition of the broader autism phenotype in families, appreciation of the importance of developmental models, advances in genetic methodology, better understanding of the relationship to intellectual deficits, recognition of syndromic autism in neurogenetic sydromes, advances in neuroimaging, and advances in animal models, both mutant mouse models and transgenic non human primate models...
April 18, 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29667725/parent-centered-communication-at-time-of-pediatric-cancer-diagnosis-a-systematic-review
#5
REVIEW
Cristiana Hentea, Erika R Cheng, Nerissa S Bauer, Emily L Mueller
There are limited data focused on parental communication needs surrounding the time when a child is diagnosed with cancer. In this systematic review, we synthesized current literature on communication preferences of parents at the time of their child's diagnosis of cancer. We identified 16 studies that yielded 4 major themes parents recognized as important: communication style, content, logistics, and healthcare team. We further identified several concepts that inform parent-centered communication practice...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667572/neurobiological-findings-associated-with-high-cognitive-performance-in-older-adults-a-systematic-review
#6
Wyllians Vendramini Borelli, Lucas Porcello Schilling, Graciane Radaelli, Luciana Borges Ferreira, Leonardo Pisani, Mirna Wetters Portuguez, Jaderson Costa da Costa
ABSTRACTObjectives:to perform a comprehensive literature review of studies on older adults with exceptional cognitive performance. DESIGN: We performed a systematic review using two major databases (MEDLINE and Web of Science) from January 2002 to November 2017. RESULTS: Quantitative analysis included nine of 4,457 studies and revealed that high-performing older adults have global preservation of the cortex, especially the anterior cingulate region, and hippocampal volumes larger than normal agers...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667571/is-it-all-bleak-a-systematic-review-of-factors-contributing-to-relationship-change-in-dementia
#7
Erin R Conway, Brittany Watson, Gemma Tatangelo, Marita McCabe
ABSTRACTBackground:The care of community-dwelling people with dementia often occurs in the context of pre-existing family relationships. The presence of dementia can result in changes to the quality of those relationships. The purpose of this systematic review is to identify factors that enhance or challenge the quality of spousal or offspring relationships in the context of dementia. METHODS: Both qualitative and quantitative studies were included in a systematic review of the literature...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667568/is-there-an-optimal-time-to-move-to-a-care-home-for-a-person-with-dementia-a-systematic-review-of-the-literature
#8
Laura Cole, Kritika Samsi, Jill Manthorpe
ABSTRACTBackground:There is limited evidence regarding how the decision evolves about whether and when it is best for a person with dementia to move to a care home. The factors leading to the timing of the decision remain particularly unclear. This systematic review of existing literature aims to gain an understanding of the decision-making timing and process to distinguish the drivers of these decisions, and to identify if there is an "optimal" or best time (if any) for a person with dementia to move to a care home...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667497/how-do-contextual-factors-influence-implementation-and-receipt-of-positive-youth-development-programs-addressing-substance-use-and-violence-a-qualitative-meta-synthesis-of-process-evaluations
#9
Kelly Dickson, G J Melendez-Torres, Adam Fletcher, Kate Hinds, James Thomas, Claire Stansfield, Simon Murphy, Rona Campbell, Chris Bonell
OBJECTIVE: Positive youth development (PYD) often aims to prevent tobacco, alcohol, and drugs use and violence. We systematically reviewed PYD interventions, synthesizing process, and outcomes evidence. Synthesis of outcomes, published elsewhere, found no overall evidence of reducing substance use or violence but notable variability of fidelity. Our synthesis of process evaluations examined how implementation varied and was influenced by context. DATA SOURCE: Process evaluations of PYD aiming to reduce substance use and violence...
May 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29667439/what-is-the-impact-of-the-2017-cochrane-systematic-review-and-meta-analysis-that-evaluated-the-use-of-pcsk9-inhibitors-for-lowering-cardiovascular-disease-and-mortality
#10
Mohamed A Jalloh, Eric J Ip, Shadi Doroudgar
In 2017, Schmidt et al. conducted a Cochrane systematic review and meta-analysis to evaluate the effect of using proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors to reduce low-density-lipoprotein- cholesterol (LDL-C) and cardiovascular disease (CVD). The Cochrane review was a systematic review and meta-analysis of 20 randomized, double-blinded trials that compared the use of PCSK9 inhibitors with statins/ezetimibe, ezetimibe, or placebo for a treatment duration of at least 24 weeks. The use of PCSK9 inhibitors lowered the risk for CVD (OR 0...
April 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29667385/chance-of-reimbursement-for-add-on-therapies-in-poland-and-in-the-world-review-of-the-reimbursement-recommendations
#11
Ewa Borowiack, Magdalena Marzec, Anna Nowotarska, Joanna Jarosz, Agata Orkisz, Patrycja Prząda-Machno
INTRODUCTION: Oncology drugs combined with standard therapies (so-called add-on therapies, e.g. bevacizumab, palbociclib) often receive negative recommendations regarding the legitimacy of public financing, issued by government agencies responsible for their assessment, i.e. health technology assessment agencies. The aim of the study was to estimate the scale of the problem related to the reimbursement of add-on therapies used in the treatment of breast and genitourinary cancers in Poland and in the world...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667259/the-cost-effectiveness-of-preventive-integrated-care-for-community-dwelling-frail-older-people-a-systematic-review
#12
REVIEW
Wilhelmina Mijntje Looman, Robbert Huijsman, Isabelle Natalina Fabbricotti
Integrated care is increasingly promoted as an effective and cost-effective way to organise care for community-dwelling frail older people with complex problems but the question remains whether high expectations are justified. Our study aims to systematically review the empirical evidence for the effectiveness and cost-effectiveness of preventive, integrated care for community-dwelling frail older people and close attention is paid to the elements and levels of integration of the interventions. We searched nine databases for eligible studies until May 2016 with a comparison group and reporting at least one outcome regarding effectiveness or cost-effectiveness...
April 17, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#13
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667198/alcohol-availability-and-onset-and-recurrence-of-alcohol-use-disorder-examination-in-a-longitudinal-cohort-with-co-sibling-analysis
#14
Katherine J Karriker-Jaffe, Henrik Ohlsson, Kenneth S Kendler, Won Kim Cook, Kristina Sundquist
BACKGROUND: Recent reviews of associations of alcohol availability with alcohol outcomes suggest findings are highly inconsistent and highlight a lack of longitudinal and causal evidence. Effect modification (moderation or statistical interaction), which could contribute to the inconsistent picture in the existing literature, has not been systematically assessed. We examined associations of alcohol availability with onset and recurrence of alcohol use disorder (AUD) using multi-level, longitudinal population data from Sweden and test hypothesized effect modifiers to identify groups for whom increased alcohol availability may be particularly risky...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667160/correction-to-relative-age-effects-across-and-within-female-sport-contexts-a-systematic-review-and-meta-analysis
#15
Kristy L Smith, Patricia L Weir, Kevin Till, Michael Romann, Stephen Cobley
An Online First version of this article was made available at https://link.springer.com/article/10.1007/s40279-018-0890-8 on 13 March 2018. Some errors were subsequently identified by the authors, particularly in regard to Table 4. Although the details pertained to in the table were correct in the original manuscript, it appears that errors were introduced during production of the article. The published article has now been updated with a corrected version of Table 4. This corrected version of the table is also shown below...
April 17, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29667159/physical-activity-throughout-the-adult-life-span-and-domain-specific-cognitive-function-in-old-age-a-systematic-review-of-cross-sectional-and-longitudinal-data
#16
REVIEW
Tobias Engeroff, Tobias Ingmann, Winfried Banzer
BACKGROUND: A growing body of literature suggests that physical activity might alleviate the age-related neurodegeneration and decline of cognitive function. However, most of this evidence is based on data investigating the association of exercise interventions or current physical activity behavior with cognitive function in elderly subjects. OBJECTIVE: We performed a systematic review and hypothesize that physical activity during the adult life span is connected with maintained domain-specific cognitive functions during late adulthood defined as age 60+ years...
April 17, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29667132/obesity-and-episodic-memory-function
#17
REVIEW
Paul D Loprinzi, Emily Frith
Obesity-related lifestyle factors, such as physical activity behavior and dietary intake, have been shown to be associated with episodic memory function. From animal work, there is considerable biological plausibility linking obesity with worse memory function. There are no published systematic reviews evaluating the effects of obesity on episodic memory function among humans, and examining whether physical activity and diet influences this obesity-memory link. Thus, the purpose of this systematic review was to evaluate the totality of research examining whether obesity is associated with episodic memory function, and whether physical activity and dietary behavior confounds this relationship...
April 17, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29667048/ethanol-lock-is-effective-on-reducing-the-incidence-of-tunneled-catheter-related-bloodstream-infections-in-hemodialysis-patients-a-systematic-review-and-meta-analysis
#18
REVIEW
Tingting Zhao, Hong Liu, Jibin Han
PURPOSE: The purpose of this meta-analysis is to evaluate the effect of ethanol lock on the incidence of catheter-related bloodstream infection (CRBSI) in patients with central venous catheters. METHODS: RCTs comparing ethanol lock with another solution lock for prevention of CRBSI were obtained by searching databases of PubMed, Embase, Web of Science and Cochrane Central Register of clinical trials for eligible randomized controlled trials (inception to December 2017)...
April 17, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29667038/complex-drug-drug-gene-disease-interactions-involving-cytochromes-p450-systematic-review-of-published-case-reports-and-clinical-perspectives
#19
REVIEW
Flavia Storelli, Caroline Samer, Jean-Luc Reny, Jules Desmeules, Youssef Daali
Drug pharmacokinetics (PK) is influenced by multiple intrinsic and extrinsic factors, among which concomitant medications are responsible for drug-drug interactions (DDIs) that may have a clinical relevance, resulting in adverse drug reactions or reduced efficacy. The addition of intrinsic factors affecting cytochromes P450 (CYPs) activity and/or expression, such as genetic polymorphisms and diseases, may potentiate the impact and clinical relevance of DDIs. In addition, greater variability in drug levels and exposures has been observed when such intrinsic factors are present in addition to concomitant medications perpetrating DDIs...
April 17, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29666970/histopathological-and-molecular-predictors-of-growth-patterns-and-recurrence-in-craniopharyngiomas-a-systematic-review
#20
REVIEW
Josephine R Coury, Brittany N Davis, Christoforos P Koumas, Giovanna S Manzano, Amir R Dehdashti
Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines...
April 17, 2018: Neurosurgical Review
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