keyword
https://read.qxmd.com/read/38531550/blood-pressure-trends-following-birth-in-infants-born-under-25-weeks-gestational-age-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Emma Persad, Björn Brindefalk, Alexander Rakow
OBJECTIVE: The aim of our study was to describe postnatal blood pressure (BP) trends and evaluate relevant dynamics and outcomes for a subgroup of extremely preterm (EPT) infants. DESIGN: Retrospective observational cohort study. SETTING: Patients admitted to Karolinska University Hospital Stockholm. PATIENTS: EPT infants born between 22+0 and 24+6 weeks' gestational age (GA) undergoing invasive, continuous BP monitoring through an umbilical arterial catheter...
March 25, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38457475/time-to-full-enteral-feeds-in-hospitalised-preterm-and-very-low-birth-weight-infants-in-nigeria-and-kenya
#2
JOURNAL ARTICLE
Zainab O Imam, Helen M Nabwera, Olukemi O Tongo, Pauline E A Andang'o, Isa Abdulkadir, Chinyere V Ezeaka, Beatrice N Ezenwa, Iretiola B Fajolu, Martha K Mwangome, Dominic D Umoru, Abimbola E Akindolire, Walter Otieno, Macrine Olwala, Grace M Nalwa, Alison W Talbert, Ismaela Abubakar, Nicholas D Embleton, Stephen J Allen
BACKGROUND: Preterm (born < 37 weeks' gestation) and very low birthweight (VLBW; <1.5kg) infants are at the greatest risk of morbidity and mortality within the first 28 days of life. Establishing full enteral feeds is a vital aspect of their clinical care. Evidence predominantly from high income countries shows that early and rapid advancement of feeds is safe and reduces length of hospital stay and adverse health outcomes. However, there are limited data on feeding practices and factors that influence the attainment of full enteral feeds among these vulnerable infants in sub-Saharan Africa...
2024: PloS One
https://read.qxmd.com/read/38446238/factors-affecting-neurodevelopmental-outcome-following-surgical-necrotising-enterocolitis-a-systematic-review
#3
REVIEW
E I Okten, M Frankl, S Wu, H Gamaty, H Thompson, I E Yardley
Surgically treated necrotising enterocolitis (sNEC) is associated with significantly worse neurodevelopmental outcomes than that seen in premature infants without NEC. We aim to review the association between factors involved in the surgical treatment of NEC and subsequent neurodevelopmental outcomes to identify potential areas for improvement. The PubMed and Embase databases were interrogated for articles reporting neurodevelopmental outcomes in babies treated surgically for NEC using key terms including: "Infant", "Necrotising enterocolitis", "Surgical", "Neurodevelopmental" and "Outcomes"...
March 6, 2024: Pediatric Surgery International
https://read.qxmd.com/read/38438129/nutrition-of-newborns-with-hypoxic-ischaemic-encephalopathy-during-therapeutic-hypothermia-a-survey-of-practice-in-polish-neonatal-care-units
#4
JOURNAL ARTICLE
Aleksandra Warchoł, Przemko Kwinta
BACKGROUND: The nutritional practice for newborns with hypoxic-ischaemic encephalopathy during therapeutic hypothermia differs among Polish neonatal care units, as no guidelines are provided. We assessed the prevailing procedures. MATERIAL AND METHODS: Data was collected through an anonymous, web-based questionnaire. We surveyed aspects of the current nutritional practices and the reasoning behind the choice of the feeding strategy. RESULTS: Thirty-one responses were obtained (31/33, 94%)...
February 1, 2024: Journal of mother and child
https://read.qxmd.com/read/38427039/influence-of-gastric-residual-assessment-in-preterm-neonates-on-time-to-achieve-enteral-feeding-the-grass-trial-multi-centre-assessor-blinded-randomised-clinical-trial
#5
JOURNAL ARTICLE
A Branagan, C Murphy, A O'Sullivan, I Bodnarova, S Feyereislova, I Berka, J Miletin, Z Stranak
PURPOSE: Gastric residual measurement is routinely performed in premature infants prior to feeding despite a lack of evidence of benefit. We aimed to evaluate if the exclusion of routine gastric residual measurement and evaluation has an impact on the time taken to achieve full enteral feeding in preterm neonates. METHODS: International multi-centre randomised controlled trial. Clinically stable, appropriate for gestational age infants between 26+0 and 30+6  weeks of gestation and less than 1...
March 1, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38342497/ursodeoxycholic-acid-for-preventing-parenteral-nutrition-associated-cholestasis-in-neonates-a-systematic-review-and-meta-analysis
#6
REVIEW
Rajendra Prasad Anne, Srikanth Puttaiah Kadyada, Abhishek Somasekhara Aradhya, Tejo Pratap Oleti
BACKGROUND: While ursodeoxycholic acid is used in treating parenteral nutrition-associated cholestasis (PNAC) in neonates, its role in prevention is unclear. OBJECTIVES: In this systematic review and meta-analysis, we attempted to determine the role of ursodeoxycholic acid in preventing PNAC in neonates. METHODS: PubMed, Embase, Cochrane Library, Scopus, and CINAHL databases were searched on September 16, 2023, for interventional studies comparing ursodeoxycholic acid with placebo...
February 11, 2024: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/38303965/gut-microbiome-derived-short-chain-fatty-acids-promising-strategies-in-necrotising-enterocolitis
#7
JOURNAL ARTICLE
María P Cifuentes, Jonathan A Chapman, Christopher J Stewart
Necrotising enterocolitis (NEC) is a devastating condition that poses a significant risk of morbidity and mortality, particularly among preterm babies. Extensive research efforts have been directed at identifying optimal treatment and diagnostic strategies but results from such studies remain unclear and controversial. Among the most promising candidates are prebiotics, probiotics and their metabolites, including short chain fatty acids (SCFAs). Such metabolites have been widely explored as possible biomarkers of gut health for different clinical conditions, with overall positive effects on the host observed...
2024: Current research in microbial sciences
https://read.qxmd.com/read/38237961/hydrocortisone-in-very-preterm-neonates-for-bpd-prevention-meta-analysis-and-effect-size-modifiers
#8
JOURNAL ARTICLE
Daniele De Luca, Sara Ferraioli, Kristi L Watterberg, Olivier Baud, Maria Rosaria Gualano
OBJECTIVES: To clarify if systemic hydrocortisone, in protocols allowing to start it before the 15th day of life, prevents bronchopulmonary dysplasia (BPD) or other adverse outcomes in very preterm neonates, and to identify any possible effect size modifiers. STUDY DESIGN: Systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Additional analyses included meta-regressions and review of biological plausibility...
January 17, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38229029/epidemiology-risk-factors-clinical-presentation-and-complications-of-late-onset-neonatal-sepsis-among-preterm-neonates-in-cyprus-a-prospective-case-control-study
#9
JOURNAL ARTICLE
Paraskevi Stylianou-Riga, Theodora Boutsikou, Panayiotis Kouis, Kyriaki Michailidou, Paraskevi Kinni, Rozeta Sokou, Zoi Iliodromiti, Constantinos Pitsios, Panayiotis K Yiallouros, Nicoletta Iacovidou
BACKGROUND: Late-onset neonatal sepsis (LOS) is common in preterm neonates, with increasing incidence in recent years. In the present study, we examined the epidemiology, clinical presentation, and complications of LOS in Cyprus and quantified possible risk factors for the development of this condition. METHODS: The study subjects were preterm neonates admitted in the Neonatal Intensive Care Unit (NICU) of Archbishop Makarios III Hospital, the only neonatal tertiary centre in Cyprus...
January 16, 2024: BMC Pediatrics
https://read.qxmd.com/read/38212403/retinopathy-of-prematurity-screening-prevalence-and-risk-factors-of-ophthalmic-complications-in-non-treated-preterm-infants
#10
JOURNAL ARTICLE
Jacob I Strelnikov, Rakesh Rao, Shahriyar Majidi, Gregg Lueder, Andrew Lee, Margaret M Reynolds
INTRODUCTION: Retinopathy of prematurity (ROP) is a vision-threatening disease of premature infants. Practice guidelines recommend that all infants screened for ROP receive follow-up eye examinations to screen for ophthalmic complications.1 The purpose of this study was to identify risk factors for the development of strabismus, amblyopia, high refractive error, and cataracts among ROP-screened, non-treated infants. METHODS: Retrospective single-centre study of ROP-screened, non-treated premature infants with ophthalmic follow-up...
January 11, 2024: Eye
https://read.qxmd.com/read/38212106/early-parenteral-nutrition-is-associated-with-improved-growth-in-very-low-birth-weight-infants-a-retrospective-study
#11
JOURNAL ARTICLE
René Liang Shen, Christian Ritz, Yanqi Li, Per Torp Sangild, Ping-Ping Jiang
OBJECTIVE: To assess the association between early initiation of parenteral nutrition (PN) and body growth in preterm infants with very low birth weight (VLBW). DESIGN: Causal inference analysis with confounders preselected by causal diagram based on the NeoNutriNet cohort containing data of infants born between 2011 and 2014 from 13 hospitals from 5 continents. PATIENTS: Neonates with birth weight ≤1500 g. INTERVENTIONS: PN initiated within the first day of life (early PN) versus within day 2-5 (delayed PN)...
January 11, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38182549/evaluation-of-the-management-of-intestinal-perforation-in-very-low-birth-infants-a-10-year-review
#12
JOURNAL ARTICLE
Ali Ahmed Raba, John Coleman, Katie Cunningham
AIM: The aim of this study was to assess outcomes of peritoneal drainage and laparotomy in the management of intestinal perforation secondary to necrotizing enterocolitis (NEC) and spontaneous intestinal perforation. METHODS: A retrospective review of all preterm infants (birthweight ≤1500 g) who underwent surgical intervention (peritoneal drainage and/or laparotomy) for intestinal perforation between March 2010 and March 2020. RESULTS: A total of 43 infants who underwent surgical intervention for intestinal perforation were included [19 (44%) with NEC and 24 (56%) with spontaneous intestinal perforation]...
January 5, 2024: Acta Paediatrica
https://read.qxmd.com/read/38163988/outcomes-and-characteristics-in-term-infants-with-necrotising-enterocolitis-and-chd
#13
JOURNAL ARTICLE
Sean T Kelleher, John Coleman, Colin J McMahon, Adam James
BACKGROUND: CHD is a significant risk factor for the development of necrotising enterocolitis. Existing literature does not differentiate between term and preterm populations. Long-term outcomes of these patients are not well understood. The aim was to investigate the baseline characteristics and outcomes of term normal birth weight infants with CHD who developed necrotising enterocolitis. METHODS: A retrospective review was performed of infants from a single tertiary centre with CHD who developed necrotising enterocolitis of Bell's Stage 1-3, over a ten-year period...
January 2, 2024: Cardiology in the Young
https://read.qxmd.com/read/38114242/factors-associated-with-the-response-to-postnatal-dexamethasone-use-in-very-low-birthweight-infants-a-nationwide-cohort-study
#14
JOURNAL ARTICLE
Seung Hwan Baek, Jeong Eun Shin, Jungho Han, In Gyu Song, Joonsik Park, Su Min Lee, Sungbo Shim, Ho Seon Eun, Soon Min Lee, Joohee Lim, So Jin Yoon, Wook Chang, Min Soo Park
BACKGROUND: Dexamethasone is widely used as a systemic corticosteroid to treat and prevent bronchopulmonary dysplasia (BPD) in preterm infants. We evaluated the current epidemiology of dexamethasone use to prevent BPD and analyse the factors associated with the response to dexamethasone in very low birthweight infants using a nationwide database. METHODS: We included very low birthweight infants born between January 2013 and December 2020 with a gestational age of 23-31 weeks using data from the Korean Neonatal Network registry...
December 18, 2023: BMJ Paediatrics Open
https://read.qxmd.com/read/38104186/fetal-inflammatory-response-spectrum-mapping-its-impact-on-severity-of-necrotising-enterocolitis
#15
JOURNAL ARTICLE
Abdul Razak, Atul Malhotra
No abstract text is available yet for this article.
December 16, 2023: Pediatric Research
https://read.qxmd.com/read/38071522/bronchopulmonary-dysplasia-temporal-trend-from-2010-to-2019-in-the-brazilian-network-on-neonatal-research
#16
JOURNAL ARTICLE
Camila Stolz, Daniela Testoni Costa-Nobre, Adriana Sanudo, Daniela Marques de Lima Mota Ferreira, José Mariano Sales Alves, Julia Paula Dos Santos, Milton Harumi Miyoshi, Nathalia Moura de Mello Silva, Fernanda Pegoraro de Godoi Melo, Regina Vieira Cavalcanti da Silva, Dafne Barcala, Marynea Silva Vale, Ligia Maria Suppo de Souza Rugolo, Edna Maria Albuquerque Diniz, Manoel Ribeiro, Sérgio T M Marba, Silvia Cwajg, José Luiz Muniz Bandeira Duarte, Walusa Assad Gonçalves Ferri, Renato S Procianoy, Leni Marcia Anchieta, José Maria de Andrade Lopes, Maria Fernanda B de Almeida, Ruth Guinsburg
OBJECTIVE: To evaluate the temporal trend of bronchopulmonary dysplasia (BPD) in preterm infants who survived to at least 36 weeks' post-menstrual age (PMA) and BPD or death at 36 weeks' PMA, and to analyse variables associated with both outcomes. DESIGN: Retrospective cohort with data retrieved from an ongoing national registry. SETTING: 19 Brazilian university public hospitals. PATIENTS: Infants born between 2010 and 2019 with 23-31 weeks and birth weight 400-1499 g...
November 27, 2023: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38059644/low-dose-diazoxide-is-safe-and-effective-in-infants-with-transient-hyperinsulinism
#17
JOURNAL ARTICLE
Neha Malhotra, Daphne Yau, Annaruby Cunjamalay, Buddhi Gunasekara, Athanasakopoulou S, Clare Gilbert, Kate Morgan, Mehul Dattani, Antonia Dastamani
OBJECTIVE: Transient hyperinsulinism (THI) is the most common form of recurrent hypoglycaemia in neonates beyond the first week of life. Although self-resolving, treatment can be required. Consensus guidelines recommend the lower end of the diazoxide 5-15 mg/kg/day range in THI to reduce the risk of adverse events. We sought to determine if doses <5 mg/kg/day of diazoxide can be effective in THI. DESIGN, PATIENTS, MEASURMENTS: Infants with THI (duration <6 months) were treated with low-dose diazoxide from October 2015 to February 2021...
December 7, 2023: Clinical Endocrinology
https://read.qxmd.com/read/38059616/commentary-on-studies-investigating-low-dose-diazoxide-in-hyperinsulinism
#18
JOURNAL ARTICLE
Tony Huynh
No abstract text is available yet for this article.
December 7, 2023: Clinical Endocrinology
https://read.qxmd.com/read/38032241/automated-oxygen-delivery-for-preterm-infants-with-respiratory-dysfunction
#19
REVIEW
Isabella G Stafford, Nai Ming Lai, Kenneth Tan
BACKGROUND: Many preterm infants require respiratory support to maintain an optimal level of oxygenation, as oxygen levels both below and above the optimal range are associated with adverse outcomes. Optimal titration of oxygen therapy for these infants presents a major challenge, especially in neonatal intensive care units (NICUs) with suboptimal staffing. Devices that offer automated oxygen delivery during respiratory support of neonates have been developed since the 1970s, and individual trials have evaluated their effectiveness...
November 30, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38004396/ppar-gamma-receptor-a-novel-target-to-improve-morbidity-in-preterm-babies
#20
REVIEW
Suresh Victor, Ben Forbes, Anne Greenough, A David Edwards
Worldwide, three-quarters of a million babies are born extremely preterm (<28 weeks gestation) with devastating outcomes: 20% die in the newborn period, a further 35% develop bronchopulmonary dysplasia (BPD), and 10% suffer from cerebral palsy. Pioglitazone, a Peroxisome Proliferator Activated Receptor Gamma (PPARγ) agonist, may reduce the incidence of BPD and improve neurodevelopment in extreme preterm babies. Pioglitazone exerts an anti-inflammatory action mediated through Nuclear Factor-kappa B repression...
October 27, 2023: Pharmaceuticals
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