keyword
MENU ▼
Read by QxMD icon Read
search

CJC

keyword
https://www.readbyqxmd.com/read/27710891/the-study-of-doping-market-how-to-produce-intelligence-from-internet-forums
#1
Thomas Pineau, Adrien Schopfer, Lionel Grossrieder, Julian Broséus, Pierre Esseiva, Quentin Rossy
Despite the predominant role played by Internet in the distribution of doping substances, little is currently known about the online offer of doping products. Therefore, the study focuses on the detection of doping substances and suppliers discussed in Internet forums. It aims at having a comprehensive understanding of products and sellers to lead an operational monitoring of the online doping market. Thirteen community forums on the Internet were investigated and one million topics were extracted with source code scrappers...
September 27, 2016: Forensic Science International
https://www.readbyqxmd.com/read/26879649/qualitative-identification-of-growth-hormone-releasing-hormones-in-human-plasma-by-means-of-immunoaffinity-purification-and-lc-hrms-ms
#2
Andre Knoop, Andreas Thomas, Eric Fichant, Philippe Delahaut, Wilhelm Schänzer, Mario Thevis
The use of growth hormone-releasing hormones (GHRHs) is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA). The aim of the present study was to develop a method for the simultaneous detection of four different GHRHs and respective metabolites from human plasma by means of immunoaffinity purification and subsequent nano-ultrahigh performance liquid chromatography-high resolution/high accuracy (tandem) mass spectrometry. The target analytes included Geref (Sermorelin), CJC-1293, CJC-1295, and Egrifta (Tesamorelin) as well as two metabolites of Geref and CJC-1293, which were captured from plasma samples using a polyclonal GHRH antibody in concert with protein A/G monolithic MSIA™ D...
May 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26771670/netnography-of-female-use-of-the-synthetic-growth-hormone-cjc-1295-pulses-and-potions
#3
REVIEW
Marie Claire Van Hout, Evelyn Hearne
BACKGROUND: Communal online folk pharmacology fuels the drive for short cuts in attaining muscle enhancement, fat loss, and youthful skin. OBJECTIVES: The study used "netnography" to explore female use of CJC-1295, a synthetic growth hormone analogue from the perspectives contained in Internet forum activity. METHODS: A systematic Internet search was conducted using variation of the term "CJC-1295"; and combined with "forum." Ninety-six hits related to bodybuilding websites where CJC-1295 was mentioned...
January 2, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/26382721/expanded-test-method-for-peptides-2-kda-employing-immunoaffinity-purification-and-lc-hrms-ms
#4
Andreas Thomas, Katja Walpurgis, Laura Tretzel, Paul Brinkkötter, Eric Fichant, Philippe Delahaut, Wilhelm Schänzer, Mario Thevis
Bioactive peptides with an approximate molecular mass of 2-12 kDa are of considerable relevance in sports drug testing. Such peptides have been used to manipulate several potential performance-enhancing processes in the athlete's body and include for example growth hormone releasing hormones (sermorelin, CJC-1293, CJC-1295, tesamorelin), synthetic/animal insulins (lispro, aspart, glulisine, glargine, detemir, degludec, bovine and porcine insulin), synthetic ACTH (synacthen), synthetic IGF-I (longR(3) -IGF-I) and mechano growth factors (human MGF, modified human MGF, 'full-length' MGF)...
November 2015: Drug Testing and Analysis
https://www.readbyqxmd.com/read/25575340/indacaterol-a-once-daily-beta2-agonist-versus-twice-daily-beta%C3%A2-agonists-or-placebo-for-chronic-obstructive-pulmonary-disease
#5
REVIEW
James B Geake, Eli J Dabscheck, Richard Wood-Baker, Christopher J Cates
BACKGROUND: Indacaterol is an inhaled long-acting beta2-agonist that is administered once daily and has been investigated as a treatment for chronic obstructive pulmonary disease (COPD). Four different doses have been investigated (75 mcg, 150 mcg, 300 mcg and 600 mcg). The relative effects of different doses of once-daily indacaterol in the management of patients with COPD are uncertain. OBJECTIVES: To compare the efficacy and safety of indacaterol versus placebo and alternative twice-daily long-acting beta2-agonists for the treatment of patients with stable COPD...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25530012/adult-consumers-of-cranberry-juice-cocktail-have-lower-c-reactive-protein-levels-compared-with-nonconsumers
#6
Kiyah J Duffey, Lisa A Sutherland
Flavonoids are important bioactive plant constituents found in abundance in berries, including cranberries. Cranberry beverages have been shown to beneficially impact urinary and cardiovascular health in clinical and observational studies, but their association with anthropometric outcomes is unknown. We examined the association between cranberry juice cocktail (CJC) consumption with flavonoid intake, and cardiometabolic and anthropometric outcomes among adults in the US data for adults (≥19 years, n = 10334) were drawn from cross-sectional National Health and Nutrition Examination Survey combined 2005-2008 survey...
February 2015: Nutrition Research
https://www.readbyqxmd.com/read/25382550/detecting-peptidic-drugs-drug-candidates-and-analogs-in-sports-doping-current-status-and-future-directions
#7
Mario Thevis, Andreas Thomas, Wilhelm Schänzer
With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry. Proving the exogenous origin of peptidic drugs and respective analogs at lowest concentration levels in biological specimens (commonly blood, serum and urine) of rather limited volume is required to pursue an action against cheating athletes...
December 2014: Expert Review of Proteomics
https://www.readbyqxmd.com/read/24049900/campylobacter-microagglutination-tests-of-swine-with-proliferative-enteritis
#8
K Chang, H J Kurtz, G E Ward, C J Gebhart
A microagglutination test was developed to determine campylobacter titers in swine with proliferative enteritis. Formalinized whole cell antigens from 24 Campylobacter isolates, including C hyointestinalis (CHI), C sputorum ss mucosalis (CSM), C jejuni/coli (CJC), C fetus ss fetus (CFF), and C fecalis (CF), were tested with 9 rabbit antisera prepared against each of 3 strains of CHI, CSM, and CJC. The CHI appeared to be antigenically homogeneous. All 6 isolates of CHI agglutinated with homologous antisera at high dilutions and did not react with CSM antisera...
July 1984: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/23351409/evidence-that-cranberry-juice-may-improve-augmentation-index-in-overweight-men
#9
RANDOMIZED CONTROLLED TRIAL
Guillaume Ruel, Annie Lapointe, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoît Lamarche, Charles Couillard
The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in order to examine the effect of consuming low-calorie cranberry juice cocktail (CJC), a source of polyphenols, on arterial stiffness in abdominally obese men. We hypothesize that regular CJC consumption will reduce circulating oxidized low-density lipoproteins concentrations and have a beneficial impact on endothelial function...
January 2013: Nutrition Research
https://www.readbyqxmd.com/read/23318763/doping-control-analysis-of-seven-bioactive-peptides-in-horse-plasma-by-liquid-chromatography-mass-spectrometry
#10
Wai Him Kwok, Emmie N M Ho, Ming Yip Lau, Gary N W Leung, April S Y Wong, Terence S M Wan
In recent years, there has been an ongoing focus for both human and equine doping control laboratories on developing detection methods to control the misuse of peptide therapeutics. Immunoaffinity purification is a common extraction method to isolate peptides from biological matrices and obtain sufficient detectability in subsequent instrumental analysis. However, monoclonal or polyclonal antibodies for immunoaffinity purification may not be commercially available, and even if available, such antibodies are usually very costly...
March 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/21871962/immunoaffinity-purification-of-peptide-hormones-prior-to-liquid-chromatography-mass-spectrometry-in-doping-controls
#11
REVIEW
Andreas Thomas, Wilhelm Schänzer, Philippe Delahaut, Mario Thevis
For most peptide hormones prohibited in elite sports the concentrations in plasma or urine are very low (pg/mL). Accordingly, hyphenated purification and enrichment steps prior to mass spectrometric detection are required to obtain sufficient doping control assays. Immunoaffinity purification in combination with nano-scale liquid chromatography coupled to high resolution/high accuracy mass spectrometry was found to have the potential of providing the necessary sensitivity and unambiguous specificity to produce reliable results...
February 2012: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/21480803/oral-consumption-of-cranberry-juice-cocktail-inhibits-molecular-scale-adhesion-of-clinical-uropathogenic-escherichia-coli
#12
Yuanyuan Tao, Paola A Pinzón-Arango, Amy B Howell, Terri A Camesano
Cranberry juice cocktail (CJC) has been shown to inhibit the formation of biofilm by uropathogenic Escherichia coli. In order to investigate whether the anti-adhesive components could reach the urinary tract after oral consumption of CJC, a volunteer was given 16 oz of either water or CJC. Urine samples were collected at 0, 2, 4, 6, and 8 hours after consumption of a single dose. The ability of compounds in the urine to influence bacterial adhesion was tested for six clinical uropathogenic E. coli strains, including four P-fimbriated strains (B37, CFT073, BF1023, and J96) and two strains not expressing P-fimbriae but exhibiting mannose-resistant hemagglutination (B73 and B78)...
July 2011: Journal of Medicinal Food
https://www.readbyqxmd.com/read/21208359/an-overview-of-once-weekly-glucagon-like-peptide-1-receptor-agonists-available-efficacy-and-safety-data-and-perspectives-for-the-future
#13
REVIEW
S Madsbad, U Kielgast, M Asmar, C F Deacon, S S Torekov, J J Holst
Incretin-based therapies, such as the injectable glucagon-like peptide-1 (GLP-1) receptor agonists and orally administered dipeptidyl peptidase-4 (DPP-4) inhibitors, have recently been introduced into clinical practice. At present, the GLP-1 receptor agonists need to be administered once or twice daily. Several once-weekly GLP-1 receptor agonists are in phase 3 development. This review examines the efficacy, safety and perspective for the future of the once-weekly GLP-1 receptor agonists: exenatide once weekly, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC, and compared them to the currently available agonists, exenatide BID and liraglutide QD...
May 2011: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/21204297/identification-of-cjc-1295-a-growth-hormone-releasing-peptide-in-an-unknown-pharmaceutical-preparation
#14
John Henninge, Milaim Pepaj, Ingunn Hullstein, Peter Hemmersbach
Several peptide drugs are being manufactured illicitly, and in some cases they are being made available to the public before entering or completing clinical trials. At the request of Norwegian police and customs authorities, unknown pharmaceutical preparations suspected to contain peptide drugs are regularly subjected to analysis. In 2009, an unknown pharmaceutical preparation was submitted for analysis by liquid chromatography-high resolution tandem mass spectrometry (LC-HRMS/MS). The preparation was found to contain a 29 amino acid peptide with a C-terminal amide function...
November 2010: Drug Testing and Analysis
https://www.readbyqxmd.com/read/20568234/direct-adhesion-force-measurements-between-e-coli-and-human-uroepithelial-cells-in-cranberry-juice-cocktail
#15
Yatao Liu, Paola A Pinzón-Arango, Amparo M Gallardo-Moreno, Terri A Camesano
SCOPE: Atomic force microscopy (AFM) was used to directly measure the nanoscale adhesion forces between P-fimbriated Escherichia coli (E. coli) and human uroepithelial cells exposed to cranberry juice, in order to reveal the molecular mechanisms by which cranberry juice cocktail (CJC) affects bacterial adhesion. METHODS AND RESULTS: Bacterial cell probes were created by attaching P-fimbriated E. coli HB101pDC1 or non-fimbriated E. coli HB101 to AFM tips, and the cellular probes were used to directly measure the adhesion forces between E...
December 2010: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/20516270/plasma-matrix-metalloproteinase-mmp-9-levels-are-reduced-following-low-calorie-cranberry-juice-supplementation-in-men
#16
Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Simone Lemieux, Benoît Lamarche, Charles Couillard
OBJECTIVE: Matrix metalloproteinase (MMP)-9, also known as gelatinase B, is implicated in the development of hypertension and atherosclerotic plaque vulnerability to rupture, an important step in the etiology of cardiovascular diseases. Studies have suggested that flavonoid consumption may be cardioprotective, and its favorable impact on circulating MMP-9 concentrations could partly explain this association. The aim of the present study was to determine the effect of consuming increasing daily doses of low-calorie cranberry juice cocktail (CJC) on plasma MMP-9 concentrations of abdominally obese men...
December 2009: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/20425571/once-weekly-glp-1-agonists-how-do-they-differ-from-exenatide-and-liraglutide
#17
REVIEW
Mikkel Christensen, Filip K Knop
Incretin mimetics offer a new modality in diabetes treatment. This modality is based on the effects of the naturally occurring glucoregulatory gut hormone glucagon-like peptide-1 (GLP-1), which counteracts several pathophysiologic traits in type 2 diabetes. GLP-1 receptor agonists with extended half-lives entailing fewer injections and presumably an improved throughout-the-day glycemic control are in clinical development. This article summarizes the physiologic effects of GLP-1; the effects of the already marketed GLP-1 analogues for daily dosing, exenatide and liraglutide; and reviews the presently published data (with emphasis on clinical pharmacokinetics, efficacy, and safety) on GLP-1 agonists, which currently are in development and intended for once-weekly dosing: albiglutide/albugon, CJC-1131, CJC-1134-PC, exenatide once weekly, and taspoglutide...
April 2010: Current Diabetes Reports
https://www.readbyqxmd.com/read/19386527/activation-of-the-gh-igf-1-axis-by-cjc-1295-a-long-acting-ghrh-analog-results-in-serum-protein-profile-changes-in-normal-adult-subjects
#18
Lucila Sackmann-Sala, Juan Ding, Lawrence A Frohman, John J Kopchick
OBJECTIVE: To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum. BACKGROUND: The search for new markers of GH activity has received extensive attention given that the current biomarkers (IGF-1, IGFBP-3 and collagen peptides) show substantial variability in the population, and are not reliably predictive of either the physiologic effects of GH therapy or the detection of GH abuse by athletes. GH releasing hormone (GHRH) is a polypeptide synthesized in the hypothalamus that binds to receptors on pituitary somatotropes to promote the synthesis and release of GH...
December 2009: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/19332789/neuronal-m3-muscarinic-acetylcholine-receptors-are-essential-for-somatotroph-proliferation-and-normal-somatic-growth
#19
Dinesh Gautam, Jongrye Jeon, Matthew F Starost, Sung-Jun Han, Fadi F Hamdan, Yinghong Cui, Albert F Parlow, Oksana Gavrilova, Ildiko Szalayova, Eva Mezey, Jürgen Wess
The molecular pathways that promote the proliferation and maintenance of pituitary somatotrophs and other cell types of the anterior pituitary gland are not well understood at present. However, such knowledge is likely to lead to the development of novel drugs useful for the treatment of various human growth disorders. Although muscarinic cholinergic pathways have been implicated in regulating somatotroph function, the physiological relevance of this effect and the localization and nature of the receptor subtypes involved in this activity remain unclear...
April 14, 2009: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/19257836/role-of-cranberry-on-bacterial-adhesion-forces-and-implications-for-escherichia-coli-uroepithelial-cell-attachment
#20
Paola A Pinzón-Arango, Yatao Liu, Terri A Camesano
Previous clinical research has suggested that the consumption of cranberry products prevents the adhesion of Escherichia coli to uroepithelial cells by causing changes in bacterial fimbriae. Atomic force microscopy was used to probe the adhesion forces between E. coli (nonfimbriated strain HB101 and the P-fimbriated variant HB101pDC1) and a model surface (silicon nitride), to determine the effect of growth in cranberry products on bacterial adhesion. Bacteria were grown in tryptic soy broth supplemented with either light cranberry juice cocktail (L-CJC) or cranberry proanthocyanidins (PACs)...
April 2009: Journal of Medicinal Food
keyword
keyword
100215
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"