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Manish Sahni, Kamal Kishor Lakhera, Ravindra Gothwal, Suresh Singh, Harsha N Mehta, Rajgovind Sharma
Angiosarcoma of bone is very rare entity, accounting for less than 1% of all primary bone sarcomas with associated poor prognosis. We hereby present a case report of angiosarcoma of tibia in a young boy and reviewed its literature and management of the disease. A 21-year young male presented to us with complaints of pain and swelling over left lower leg since last 3 months. On evaluation, MRI lower leg revealed multiloculated lesion of size 32×36×52 mm showing multiple fluid-fluid levels which was hyperintense on T2 images in left distal tibial metaphysis showing endosteal scalloping with cortical destruction along lateral border and abuts the physis...
March 2024: Indian Journal of Surgical Oncology
#22
JOURNAL ARTICLE
Encarnación Gutiérrez-Carretero, Eduardo Arana-Rueda, Antonio Ortiz-Carrellán, Alonso Pedrote-Martínez, Mariano García-de-la-Borbolla, Arístides De Alarcón
Background: Cardiac device infections are serious adverse events associated with considerable morbidity and mortality, significant costs, and increased healthcare utilization. The aim of this study is to calculate the costs of treatment of cardiac implantable electrostimulation device (CIED)-related infections for different types of infection (local or systemic) and therapeutic approaches. Patients and Methods : Single-center cohort (1985-2018). The costs of the CIED-related infections were analyzed according to initial treatment (antimicrobial treatment exclusively, local approach, or transvenous lead extraction (TLE))...
March 7, 2024: Microorganisms
#23
JOURNAL ARTICLE
Yoji Okahara, Kyoko Aoyagi, Hiroto Iwasa, Yoshinori Higuchi
Background : In temporal lobe epilepsy (TLE), estimating the potential risk of language dysfunction before surgery is a necessary procedure. Functional MRI (fMRI) is considered the most useful to determine language lateralization noninvasively. However, there are no standardized language fMRI protocols, and several issues remain unresolved. In particular, the language tasks normally used are predominantly active paradigms that require the overt participation of patients, making assessment difficult for pediatric patients or patients with intellectual disabilities...
March 15, 2024: Journal of Clinical Medicine
#24
JOURNAL ARTICLE
Eunju Leem, Sehwan Kim, Chanchal Sharma, Youngpyo Nam, Tae Yeon Kim, Minsang Shin, Seok-Geun Lee, Jaekwang Kim, Sang Ryong Kim
Although granule cell dispersion (GCD) in the hippocampus is known to be an important feature associated with epileptic seizures in temporal lobe epilepsy (TLE), the endogenous molecules that regulate GCD are largely unknown. In the present study, we have examined whether there is any change in AEG-1 expression in the hippocampus of a kainic acid (KA)-induced mouse model of TLE. In addition, we have investigated whether the modulation of astrocyte elevated gene-1 ( AEG-1 ) expression in the dentate gyrus (DG) by intracranial injection of adeno-associated virus 1 (AAV1) influences pathological phenotypes such as GCD formation and seizure susceptibility in a KA-treated mouse...
March 20, 2024: Biomolecules
#25
JOURNAL ARTICLE
Carlos Nascimento, Vasco Guerreiro-Pinto, Seweryn Pawlak, Ana Caulino-Rocha, Laia Amat-Garcia, Diana Cunha-Reis
Novelty detection, crucial to episodic memory formation, is impaired in epileptic patients with mesial temporal lobe resection. Mismatch novelty detection, that activates the hippocampal CA1 area in humans and is vital for memory reformulation and reconsolidation, is also impaired in patients with hippocampal lesions. In this work, we investigated the response to mismatch novelty, as occurs with the new location of known objects in a familiar environment, in the Li2+ -pilocarpine rat model of TLE and its correlation with hippocampal monoaminergic markers...
March 12, 2024: Biomedicines
#26
JOURNAL ARTICLE
Alessandro Gaeta, Lilian Juliana Lissner, Veronica Alfano, Pierangelo Cifelli, Alessandra Morano, Cristina Roseti, Angela Di Iacovo, Eleonora Aronica, Eleonora Palma, Gabriele Ruffolo
Among the most prevalent neurological disorders, epilepsy affects about 1% of the population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism that drives the pathological phenomena that ultimately lead to generation and recurrence of seizures. Using both a "microtransplantation technique" and synaptosomes preparations from drug-resistant temporal lobe epilepsies (TLEs), we used the technique of two-electrode voltage clamp to record GABA-evoked currents, focusing selectively on the synaptic "fast inhibition" mediated by low-affinity GABAA receptors...
March 2, 2024: Membranes
#27
JOURNAL ARTICLE
Pae Sun Suh, Ji Eun Park, Yun Hwa Roh, Seonok Kim, Mina Jung, Yong Seo Koo, Sang-Ahm Lee, Yangsean Choi, Ho Sung Kim
OBJECTIVE: To evaluate the diagnostic performance and image quality of 1.5-mm slice thickness MRI with deep learning-based image reconstruction (1.5-mm MRI + DLR) compared to routine 3-mm slice thickness MRI (routine MRI) and 1.5-mm slice thickness MRI without DLR (1.5-mm MRI without DLR) for evaluating temporal lobe epilepsy (TLE). MATERIALS AND METHODS: This retrospective study included 117 MR image sets comprising 1.5-mm MRI + DLR, 1.5-mm MRI without DLR, and routine MRI from 117 consecutive patients (mean age, 41 years; 61 female; 34 patients with TLE and 83 without TLE)...
April 2024: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
#28
REVIEW
Lorenza Guarnieri, Nicola Amodio, Francesca Bosco, Sara Carpi, Martina Tallarico, Luca Gallelli, Vincenzo Rania, Rita Citraro, Antonio Leo, Giovambattista De Sarro
Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy. The identification of innovative clinical biomarkers capable of categorizing patients with TLE, allowing for improved treatment and outcomes, still represents an unmet need. Circulating microRNAs (c-miRNAs) are short non-coding RNAs detectable in body fluids, which play crucial roles in the regulation of gene expression. Their characteristics, including extracellular stability, detectability through non-invasive methods, and responsiveness to pathological changes and/or therapeutic interventions, make them promising candidate biomarkers in various disease settings...
March 17, 2024: Non-Coding RNA
#29
JOURNAL ARTICLE
Tong Jiang, Shuyu Liang, Xiaohan Zhang, Shasha Dong, HaiFang Zhu, Ying Wang, Yanping Sun
A growing number of clinical and animal studies suggest that the nucleus accumbens (NAc), especially the shell, is involved in the pathogenesis of temporal lobe epilepsy (TLE). However, the role of parvalbumin (PV) GABAergic neurons in the NAc shell involved in TLE is still unclear. In this study, we induced a spontaneous TLE model by intrahippocampal administration of kainic acid (KA), which generally induce acute seizures in first 2 h (acute phase) and then lead to spontaneous recurrent seizures after two months (chronic phase)...
March 22, 2024: Neurobiology of Disease
#30
JOURNAL ARTICLE
Sam S Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Michael R Sperling, Joseph I Tracy
OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node. We implemented a more selective, edge-wise approach that allowed for identification of the individual connections unique to FBTCS. METHODS: T1-weighted and diffusion-weighted images were obtained from 22 patients with solely focal seizures (FS), 43 FBTCS patients, and 65 age/sex-matched healthy participants (HPs), yielding streamline (STR) connectome matrices...
March 22, 2024: Epilepsia
#31
JOURNAL ARTICLE
Lara C Schipmann, Viviane Moeller, Juliane Krimnitz, Marwin Bannehr, Tobias Siegfried Kramer, Anja Haase-Fielitz, Christian Butter
INTRODUCTION: Infections associated with cardiac implantable electronic devices (CIEDs) are a multifactorial disease that leads to increased morbidity and mortality. OBJECTIVE: The aim was to analyze patient-, disease- and treatment-related characteristics including microbiological and bacterial spectrum according to survival status and to identify risk factors for 1- and 3-year mortality in patients with local and systemic CIED infection. METHODS: In a retrospective cohort study, we analyzed data from patients with CIED-related local or systemic infection undergoing successful transvenous lead extraction (TLE)...
March 21, 2024: Heart and Vessels
#32
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
#33
JOURNAL ARTICLE
Justin Z Lee, Fahimeh Talaei, Min-Choon Tan, Komandoor Srivathsan, Dan Sorajja, Arturo Valverde, Luis Scott, Samuel J Asirvatham, Fred Kusumoto, Siva K Mulpuru, Yong-Mei Cha
BACKGROUND: Long-term outcomes of sterile lead management strategies of lead abandonment (LA) or transvenous lead extraction (TLE) remain unclear. METHODS: We performed a retrospective study of a population residing in southeastern Minnesota with follow-up at the Mayo Clinic and its health systems. Patients who underwent LA or TLE of sterile leads from January 1, 2000, to January 1, 2011, and had follow-up for at least 10 years or until their death were included...
March 15, 2024: Pacing and Clinical Electrophysiology: PACE
#34
JOURNAL ARTICLE
Alfonso Fajardo-Valdez, Vicente Camacho-Téllez, Raúl Rodríguez-Cruces, María Luisa García-Gomar, Erick Humberto Pasaye, Luis Concha
Temporal lobe epilepsy (TLE) is a common form of medically intractable epilepsy. Although seizures originate in mesial temporal structures, there are widespread abnormalities of gray and white matter beyond the temporal lobes that negatively impact functional networks and cognition. Previous studies have focused either on the global impact on functional networks, or on the functional correlates of specific cognitive abilities. Here, we use a two-pronged approach to evaluate the link between whole-brain functional connectivity (FC) anomalies to overall cognitive performance, and how such abnormal connectivity alters the fronto-parietal brain regions involved in working memory (WMem), a cognitive disability often reported by TLE patients...
2024: PloS One
#35
JOURNAL ARTICLE
Norihiko Kawaguchi, Yushi Inoue, Kiyohito Terada, Naotaka Usui
OBJECTIVE: Enduring anterograde amnesia is caused by lesions in bilateral mesial temporal lobes. However, whether transient dysfunction of bilateral mesial temporal regions induces reversible amnesia has not been proven. We investigated this association in patients with epilepsy and analyzed the electroclinical correlation during pure amnestic seizures (PAS). PAS are defined as seizures with anterograde amnesia as the only ictal manifestation, accompanied by preserved responsiveness and other cognitive functions...
March 13, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
#36
JOURNAL ARTICLE
Yuchao Jiang, Wei Li, Jinmei Li, Xiuli Li, Heng Zhang, Xiutian Sima, Luying Li, Kang Wang, Qifu Li, Jiajia Fang, Lu Jin, Qiyong Gong, Dezhong Yao, Dong Zhou, Cheng Luo, Dongmei An
Artificial intelligence provides an opportunity to try to redefine disease subtypes based on similar pathobiology. Using a machine-learning algorithm (Subtype and Stage Inference) with cross-sectional MRI from 296 individuals with focal epilepsy originating from the temporal lobe (TLE) and 91 healthy controls, we show phenotypic heterogeneity in the pathophysiological progression of TLE. This study was registered in the Chinese Clinical Trials Registry (number: ChiCTR2200062562). We identify two hippocampus-predominant phenotypes, characterized by atrophy beginning in the left or right hippocampus; a third cortex-predominant phenotype, characterized by hippocampus atrophy after the neocortex; and a fourth phenotype without atrophy but amygdala enlargement...
March 12, 2024: Nature Communications
#37
JOURNAL ARTICLE
Liesbeth François, Alessia Romagnolo, Mark J Luinenburg, Jasper J Anink, Patrice Godard, Marek Rajman, Jonathan van Eyll, Angelika Mühlebner, Andrew Skelton, James D Mills, Stefanie Dedeurwaerdere, Eleonora Aronica
Epilepsy is a chronic and heterogenous disease characterized by recurrent unprovoked seizures, that are commonly resistant to antiseizure medications. This study applies a transcriptome network-based approach across epilepsies aiming to improve understanding of molecular disease pathobiology, recognize affected biological mechanisms and apply causal reasoning to identify therapeutic hypotheses. This study included the most common drug-resistant epilepsies (DREs), such as temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), and mTOR pathway-related malformations of cortical development (mTORopathies)...
March 11, 2024: Nature Communications
#38
JOURNAL ARTICLE
Melanie Widmann, Andreas Lieb, Barbara Fogli, Angela Steck, Anna Mutti, Christoph Schwarzer
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures in males...
March 9, 2024: Experimental Neurology
#39
JOURNAL ARTICLE
Kun Guo, Zhiyong Quan, Guiyu Li, Baojuan Li, Fei Kang, Jing Wang
OBJECTIVE: This study utilized a data-driven Bayesian model to automatically identify distinct latent disease factors represented by overlapping glucose metabolism patterns from 18 F-Fluorodeoxyglucose PET (18 F-FDG PET) to analyze heterogeneity among patients with TLE. METHODS: We employed unsupervised machine learning to estimate latent disease factors from 18 F-FDG PET scans, representing whole-brain glucose metabolism patterns in seventy patients with TLE. We estimated the extent to which multiple distinct factors were expressed within each participant and analyzed their relevance to epilepsy burden, including seizure onset, duration, and frequency...
March 8, 2024: Neurological Sciences
#40
JOURNAL ARTICLE
SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Pegah Mirzapour, Arian Afzalian, Ramin Shahidi, Mohsen Dashti, Afsaneh Ghasemzadeh, Parinaz Paranjkhoo, Zahra Parsaei, Ava Pashaei, Parsa Mohammadi, Mohammad Sadeq Najafi, Sona Mahrokhi, Parisa Matini, Ali Moradi, Amirali Karimi, Solaiman Afroughi, Esmaeil Mehraeen, Omid Dadras
INTRODUCTION: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused the outbreak of coronavirus disease 2019 (COVID-19) in late 2019 in Wuhan, China. In early 2020, the disease spread rapidly around the world. Since the pandemic, SARS-CoV-2 has evolved dramatically into a wide variety of variants endowed with devastating properties. As of March 6, 2022, five SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, Delta, and Omicron strains have been identified...
March 5, 2024: Infectious Disorders Drug Targets
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