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https://www.readbyqxmd.com/read/29772217/altered-activity-and-information-flow-in-the-default-mode-network-of-pilocarpine-induced-epilepsy-rats
#1
Yan Cui, Shuang Yu, Tianjiao Zhang, Yangsong Zhang, Yang Xia, Dezhong Yao, Daqing Guo
Temporal lobe epilepsy (TLE) is considered a brain activity disorder that is likely related to allomnesia and conscious disturbance. In rodents, TLE epileptiform discharges can be triggered by systemic administration of a dose of pilocarpine. However, how these pilocarpine-induced epileptiform discharges generate and propagate through the whole brain has not been well studied. In this study, we sought to assess alterations of activity and information flow in the default mode network (DMN) during TLE epileptiform discharges in pilocarpine-induced TLE rats...
May 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29767353/influences-of-temporal-lobe-epilepsy-and-temporal-lobe-resection-on-olfaction
#2
Richard L Doty, Isabelle Tourbier, Jessica K Neff, Jonathan Silas, Bruce Turetsky, Paul Moberg, Taehoon Kim, John Pluta, Jaqueline French, Ashwini D Sharan, Michael J Sperling, Natasha Mirza, Anthony Risser, Gordon Baltuch, John A Detre
Although temporal lobe epilepsy (TLE) and resection (TLR) impact olfactory eloquent brain structures, their influences on olfaction remain enigmatic. We sought to more definitively assess the influences of TLE and TLR on olfaction using three well-validated olfactory tests and measuring  the tests' associations with the volume of numerous temporal lobe brain structures. The University of Pennsylvania Smell Identification Test and an odor detection threshold test were administered to 71 TLE patients and 71 age- and sex-matched controls; 69 TLE patients and controls received an odor discrimination/memory test...
May 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29745545/-tract-based-spatial-statistics-analysis-on-the-white-matter-of-patients-with-temporal-lobe-epilepsy-and-automatic-recognition
#3
Di Zhao, Shengwen Guo, Congling Wu, Chunren Lai, Lina Cheng, Wensheng Wang
This study aims to determine the salient brain regions with abnormal changes in white matter structures from diffusion tensor imaging (DTI) images of the patients with temporal lobe epilepsy (TLE), and to discriminate the patients with TLE from normal controls (NCs). Firstly, the DTI images from 50 subjects (28 NCs and 22 TLE) were acquired. Secondly, the four measures including the fractional anisotropy (FA), the mean diffusivity (MD), the axial diffusivity (AD) and the radial diffusivity (RD) were calculated...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29743900/complications-of-electrotherapy-the-dark-side-of-treatment-with-cardiac-implantable-electronic-devices
#4
REVIEW
Szymon Domagała, Michał Domagała, Jakub Chyła, Celina Wojciechowska, Marianna Janion, Anna Polewczyk
In the past years we have been observing the dynamic development of electrotherapy, as evidenced by the steadily rising number of implanted pacemakers (PM), as well as devices used in the treatment of dangerous arrhythmia and heart failure, such as implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy (CRT-P/D). This is a consequence of the ageing of the populations of the majority of developed countries and also the gradually widening indications for the use of such devices. Along with the observed rise in the number of new implantations, the number of complications of electrotherapy is rising as well...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29740014/different-patterns-of-epileptiform-like-activity-are-generated-in-the-sclerotic-hippocampus-from-patients-with-drug-resistant-temporal-lobe-epilepsy
#5
Selvin Z Reyes-Garcia, Carla A Scorza, Noemi S Araújo, Nancy N Ortiz-Villatoro, Anaclara Prada Jardim, Ricardo Centeno, Elza Márcia Targas Yacubian, Jean Faber, Esper A Cavalheiro
Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737322/robotic-assisted-minimally-invasive-oesophagectomy-for-cancer-an-initial-experience
#6
Chinnusamy Palanivelu, Sumanta Dey, Sandeep Sabnis, Raghavendra Gupta, Bharath Cumar, Saravana Kumar, Ramesh Natarajan, Parthasarathi Ramakrishnan
Background: The morbidity related to radical oesophagectomy can be reduced by adopting minimally invasive techniques. Over 250 thoraco-laparoscopic oesophagectomy (TLE) was done in our centre over the last 15 years, before adopting robotic surgery as the latest innovation in the field of minimally invasive surgery. Here, we share our initial experience of robotic-assisted minimally invasive oesophagectomy (RAMIE) for carcinoma oesophagus. Methods: A prospective observational study conducted from February to December 2017...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29736224/prognostic-value-of-ictal-onset-patterns-in-postsurgical-outcome-of-temporal-lobe-epilepsy
#7
Jafar Mehvari-Habibabadi, Reza Basiratnia, Houshang Moein, Mohamad Zare, Majid Barakatain, Yahya Aghakhani, Nasim Tabrizi
Background: To investigate ictal onset patterns (IOP) in scalp electroencephalography (EEG) of patients with temporal lobe epilepsy (TLE) and their prognostic effect on the postoperative outcome. Methods: We conducted a retrospective cohort study between 2011 and 2015 in our referral Epilepsy Surgery Center enrolling adult patients with refractory TLE and a visible epileptogenic lesion in magnetic resonance imaging (MRI), who underwent epilepsy surgery. Demographic, clinical and MRI findings were collected and ictal findings during video-EEG monitoring were reviewed in detail...
October 7, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29729534/the-surgical-outcome-of-patients-with-bilateral-temporal-lobe-epilepsy
#8
Xiaoxia Zhou, Tao Yu, Guojun Zhang, Duanyu Ni, Liang Qiao, Xueyuan Wang, Cuiping Xu, Chang Liu, Yuping Wang, Yongjie Li
OBJECTIVES: The purpose of this study is to explore the surgical outcome of unilateral anterior temporal lobectomy (ATL) for patients with bilateral temporal lobe epilepsy (BTLE). METHODS: We retrospectively reviewed the data of patients who were diagnosed with BTLE by scalp electroencephalogram (EEG) and underwent ATL from 2001 to 2015. In addition, 80 patients were randomly selected as a control group. RESULTS: One hundred seventeen patients were included in this study and were divided into four groups by intracranial recordings as follows: 78 patients with unilateral seizure onset (Group 1), 13 patients with lateralizable dominant seizure onset (Group 2), 14 patients with lateralizable neuroimaging abnormalities (Group 3), and 12 patients without lateralizable dominant seizure onset or neuroimaging abnormalities (Group 4)...
April 26, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29728816/quantitative-mr-spectroscopy-reveals-metabolic-changes-in-the-dorsolateral-prefrontal-cortex-of-patients-with-temporal-lobe-epilepsy
#9
Qiaoyue Tan, Huaiqiang Sun, Weina Wang, Xintong Wu, Nanya Hao, Xiaorui Su, Xibiao Yang, Simin Zhang, Jingkai Su, Qiang Yue, Qiyong Gong
OBJECTIVE: To characterize possible metabolic changes of the dorsolateral prefrontal cortex (DLPFC) in patients with temporal lobe epilepsy (TLE). METHODS: Quantitative proton magnetic resonance spectroscopy (1H-MRS) studies were performed on 24 TLE patients and 22 healthy controls. Metabolite concentrations were calculated using a linear combination model (LCModel) and corrected for cerebrospinal fluid contamination. Comparisons were performed between the TLE patients and the controls and between the left DLPFC and right DLPFC in each group...
May 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29723519/bio-electrochemical-microelectrode-arrays-for-glutamate-and-electrophysiology-detection-in-hippocampus-of-temporal-lobe-epileptic-rats
#10
Ziyue Li, Yilin Song, Guihua Xiao, Fei Gao, Shengwei Xu, Mixia Wang, Yu Zhang, Fengru Guo, Jie Liu, Yang Xia, Xinxia Cai
Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder, characterized by sudden, repeated and transient central nervous system dysfunction. For better understanding of TLE, bio-nanomodified microelectrode arrays (MEA) are designed, for the achievement of high-quality simultaneous detection of glutamate signals (Glu) and multi-channel electrophysiological signals including action potentials (spikes) and local field potentials (LFPs). The MEA was fabricated by Micro-Electro-Mechanical System fabrication technology and all recording sites were modified with platinum black nano-particles, the average impedance decreased by nearly 90 times...
April 30, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29709878/genetic-polymorphisms-of-the-5ht-receptors-are-not-related-with-depression-in-temporal-lobe-epilepsy-caused-by-hippocampal-sclerosis
#11
Silvia Vincentiis, Juliana Alcantara, Patricia Rzezak, Daniel S Kerr, Wagner F Gattaz, Helio van der Linden, Bernardo Dos Santos, Sebastiao E Melo-Souza, Francisco Arruda, Paulo Ragazzo, Tiffany Chaim-Avancini, Mauricio H Serpa, Fernando Fernandes, Ricardo A Moreno, Geraldo Busatto, Ruda Alessi, Renata Demarque, Kette D Valente
BACKGROUND: Temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS) is the most frequent form of drug-resistant epilepsy in adults. Mood disorders are the most frequent psychiatric comorbidities observed in these patients. Common pathophysiological mechanisms of epilepsy and psychiatric comorbidities include abnormalities in the serotonin pathway. The primary goal of this study was to determine the possible association between polymorphisms of genes encoding the serotonin receptors 5HT1A (rs6295), 5HT1B (rs6296), and 5HT2C (rs6318) and the presence of mood disorders in patients with TLE-HS...
April 27, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29698733/evidence-for-degraded-low-frequency-verbal-concepts-in-left-resected-temporal-lobe-epilepsy-patients
#12
M Visser, C Forn, M A Lambon Ralph, P Hoffman, A Gómez Ibáñez, A Sanjuan-Tomas, P Rosell Negre, V Villanueva, C Ávila
According to a large neuropsychological and neuroimaging literature, the bilateral anterior temporal lobe (ATL) is a core region for semantic processing. It seems therefore surprising that semantic memory appears to be preserved in temporal lobe epilepsy (TLE) patients with unilateral ATL resection. However, recent work suggests that the bilateral semantic system is relatively robust against unilateral damage and semantic impairments under these circumstances only become apparent with low frequency specific concepts...
April 23, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29697139/increased-cardiac-stiffness-is-associated-with-autonomic-dysfunction-in-patients-with-temporal-lobe-epilepsy
#13
Guilherme L Fialho, Peter Wolf, Roger Walz, Katia Lin
Autonomic dysfunction is linked to sudden death regardless of the presence of structural heart disease. The pathway from autonomic dysfunction to sudden death is not fully understood, but myocardial sympathetic stimulation leading to arrhythmia and/or cardiac fibrosis might play a role. Our goal was to evaluate cardiac stiffness by echocardiography and its association with clinical, structural, and autonomic variables in people with epilepsy (PWE) compared to healthy controls. A 12-lead electrocardiogram, treadmill testing, and transthoracic echocardiography from 30 patients with temporal lobe epilepsy (TLE) without any known cardiovascular disorders were compared to 30 individuals without epilepsy matched by sex, age, and body mass index...
April 26, 2018: Epilepsia
https://www.readbyqxmd.com/read/29696792/agkihpin-a-distinct-svtle-from-the-venom-of-gloydius-halys-pallas-purification-characterization-and-structure-activity-determination
#14
Yulu Tang, Miao Huang, Qiping Hu, Huayu Wu, Jiali Yao, Kejian Sun, Xiaolong Li
Blood clots produced by Snake-venom thrombin-like enzymes (SVTLEs) are cleared rapidly, that makes SVTLEs attractive as potential candidates for antithrombotic therapy. We isolated a SVTLE, agkihpin, from the venom of Gloydius halys Pallas. Agkihpin was confirmed to a single-chain TLE with molecular mass of 25.5 kD, pI of 7.43, optimal pH of 8.0 (hydrolyzing TAME), linked carbohydrate absent, and weak fibrinogen clotting activity. It also found that (1) G. Halys might be the latest species in SVTLEs phylogenetic tree; (2) different level of conservation was shown among the SVTLEs from the Viperidae snakes...
April 25, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29692969/emotional-stimuli-provoked-seizures-potentially-misdiagnosed-as-psychogenic-non-epileptic-attacks-a-case-of-temporal-lobe-epilepsy-with-amygdala-enlargement
#15
Hidetaka Tamune, Go Taniguchi, Susumu Morita, Yousuke Kumakura, Shinsuke Kondo, Kiyoto Kasai
The association between emotional stimuli and temporal lobe epilepsy (TLE) is largely unknown. Here, we report the case of a depressed, 50-year-old female complaining of episodes of a "spaced out" experience precipitated by emotional stimuli. Psychogenic non-epileptic attacks were suspected. However, video-EEG coupled with emotional stimuli-provoked procedures and MRI findings of amygdala enlargement, led to the diagnosis of left TLE. Accurate diagnosis and explanation improved her subjective depression and seizure frequency...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29685768/accelerated-long-term-forgetting-and-behavioural-difficulties-in-children-with-epilepsy
#16
Michael B Gascoigne, Mary Lou Smith, Belinda Barton, Richard Webster, Deepak Gill, Suncica Lah
Patients with epilepsy have been shown to exhibit a range of memory deficits, including the rapid forgetting of newly-learned material over long, but not short, delays (termed accelerated long-term forgetting; ALF). Behavioural problems, such as mood disorders and social difficulties, are also overrepresented among children with epilepsy, when compared to patients with other chronic diseases and the general population. We investigated whether ALF was associated with behavioural or psychosocial deficits in children with epilepsy...
March 30, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29680731/automatic-ictal-onset-source-localization-in-presurgical-epilepsy-evaluation
#17
Johannes Koren, Gerhard Gritsch, Susanne Pirker, Johannes Herta, Hannes Perko, Tilmann Kluge, Christoph Baumgartner
OBJECTIVE: To test the diagnostic accuracy of a new automatic algorithm for ictal onset source localization (IOSL) during routine presurgical epilepsy evaluation following STARD (Standards for Reporting of Diagnostic Accuracy) criteria. METHODS: We included 28 consecutive patients with refractory focal epilepsy (25 patients with temporal lobe epilepsy (TLE) and 3 with extratemporal epilepsy) who underwent resective epilepsy surgery. Ictal EEG patterns were analyzed with a novel automatic IOSL algorithm...
June 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29678905/phosphorylation-of-xiap-at-threonine-180-controls-its-activity-in-wnt-signaling
#18
Victoria H Ng, Brian I Hang, Leah M Sawyer, Leif R Neitzel, Emily E Crispi, Kristie L Rose, Tessa M Popay, Alison Zhong, Laura A Lee, William P Tansey, Stacey Huppert, Ethan Lee
X-linked Inhibitor of Apoptosis (XIAP) plays an important role in preventing apoptotic cell death. XIAP has been shown to participate in signaling pathways, including Wnt signaling. XIAP regulates Wnt signaling by promoting the monoubiquitination of the co-repressor Groucho/TLE, decreasing its affinity for TCF/Lef and allowing assembly of transcriptionally active β-catenin-TCF/Lef complexes. We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180 and that an alanine mutant (XIAPT180A ) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos...
April 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29672695/new-onset-of-phrenic-nerve-palsy-after-laser-assisted-transvenous-lead-extraction-a-single-centre-experience
#19
Tardu Özkartal, François Regoli, Giulio Conte, Maria Luce Caputo, Catherine Klersy, Tiziano Moccetti, Angelo Auricchio
Aims: Phrenic nerve palsy (PNP) after mechanical transvenous lead extraction (TLE) was recently described for the first time. We aimed to analyse our TLE database for the presence of PNP. Methods and results: All consecutive patients referred to our institution were included in this study. Every available post-procedural chest X-ray was compared to the routinely performed pre-procedural radiographs. A newly elevated hemidiaphragm ipsilateral to TLE was considered indicative of PNP...
April 16, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29668992/pediatric-temporal-lobe-epilepsy-surgery-in-bonn-and-review-of-the-literature
#20
D Ryan Ormond, Hans Clusmann, Robert Sassen, Christian Hoppe, Christoph Helmstaedter, Johannes Schramm, Alexander Grote
BACKGROUND: Epilepsy surgery is well established as safe and successful for children with temporal lobe epilepsy (TLE). Despite evidence from available data, there remains some reluctance to refer children with medically refractory epilepsy for preoperative evaluation and workup for possible surgery. OBJECTIVE: To present the largest case series of pediatric (TLE) patients thus far, in order to better understand the predictability of preoperative evaluation on seizure outcome, and to better understand longitudinal outcomes in a large pediatric cohort...
April 13, 2018: Neurosurgery
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