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https://www.readbyqxmd.com/read/29141184/unrecognized-venous-injuries-after-cardiac-implantable-electronic-device-transvenous-lead-extraction
#1
Khaldoun G Tarakji, Walid Saliba, Danny Markabawi, E Rene Rodriguez, Yoaav Krauthammer, Michael P Brunner, Ayman A Hussein, Bryan Baranowski, Daniel J Cantillon, Mohamed Kanj, Mark Niebauer, Jack Rickard, Thomas Callahan, Mingyuan Shao, David O Martin, Oussama M Wazni, Bruce L Wilkoff, Carmela D Tan
BACKGROUND: Major complication rate of transvenous lead extraction (TLE) is estimated around 1-2.0%. Laceration of the central veins can be fatal. OBJECTIVES: to define the incidence and extent of venous injuries on a microscopic level after TLE and compare it with the incidence of clinically documented events of venous laceration. METHODS: We studied all patients who underwent TLE at our tertiary center within 30 months via a variety of techniques...
November 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29134387/should-the-rectal-defect-be-closed-following-transanal-local-excision-of-rectal-tumors-a-systematic-review-and-meta-analysis
#2
REVIEW
B Menahem, A Alves, R Morello, J Lubrano
BACKGROUND: Transanal local excision (TLE) has become the treatment of choice for benign and early-stage selected malignant tumors. However, closure of the rectal wall defect remains a controversial point and the available literature still remains unclear. Our aim was to determine through a systematic review of the literature and a meta-analysis of relevant studies whether or not the wall defect following TLE of rectal tumors should be closed. METHODS: Medline and the Cochrane Trials Register were searched for trials published up to December 2016 comparing open versus closed management of the surgical rectal defect after TLE of rectal tumors...
November 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29130506/animal-models-of-acquired-epilepsy-insights-into-mechanisms-of-human-epileptogenesis
#3
Albert J Becker
In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth but develop later in life. This holds particularly true for epilepsies with a focal seizure origin including focal cortical dysplasias (FCDs) and temporal lobe epilepsy (TLE). TLE most frequently has its seizure onset in the hippocampal formation. Hippocampal biopsies of pharmacoresistant TLE patients undergoing epilepsy surgery for seizure control most frequently reveal the damage pattern of hippocampal sclerosis, i...
November 12, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29128469/the-different-patterns-of-seizure-induced-aphasia-in-temporal-lobe-epilepsies
#4
Agnès Trebuchon, Isabelle Lambert, Bernard Guisiano, Aileen McGonigal, Charline Perot, Francesca Bonini, Romain Carron, Catherine Liegeois-Chauvel, Patrick Chauvel, Fabrice Bartolomei
OBJECTIVES: Ictal language disturbances may occur in dominant hemisphere temporal lobe epilepsy (TLE), but little is known about the precise anatomoelectroclinical correlations. This study investigated the different facets of ictal aphasia in intracerebrally recorded TLE. METHODS: Video-stereoelectroencephalography (SEEG) recordings of 37 seizures in 17 right-handed patients with drug-resistant TLE were analyzed; SEEG electroclinical correlations between language disturbance and involvement of temporal lobe structures were assessed...
November 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29126704/decreased-neurite-density-within-frontostriatal-networks-is-associated-with-executive-dysfunction-in-temporal-lobe-epilepsy
#5
Anny Reyes, Vedang S Uttarwar, Yu-Hsuan A Chang, Akshara R Balachandra, Chris J Pung, Donald J Hagler, Briana M Paul, Carrie R McDonald
OBJECTIVE: Executive dysfunction is observed in a sizable number of patients with refractory temporal lobe epilepsy (TLE). The frontostriatal network has been proposed to play a significant role in executive functioning, however, because of the complex architecture of these tracts, it is difficult to generate measures of fiber tract microstructure using standard diffusion tensor imaging. To examine the association between frontostriatal network compromise and executive dysfunction in TLE, we applied an advanced, multishell diffusion model, restriction spectrum imaging (RSI), that isolates measures of intraaxonal diffusion and may provide better estimates of fiber tract compromise in TLE...
November 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29111385/jnk1-inhibition-by-licochalcone-a-leads-to-neuronal-protection-against-excitotoxic-insults-derived-of-kainic-acid
#6
Oriol Busquets, Miren Ettcheto, Ester Verdaguer, Rubén Dario, Carme Auladell, Carlos Beas-Zarate, Jaume Folch, Antoni Camins
The mitogen-activated protein kinase family (MAPK) is an important group of enzymes involved in cellular responses to diverse external stimuli. One of the members of this family is the c-Jun-N-terminal kinase (JNK). The activation of the JNK pathway has been largely associated with the pathogenesis that occurs in epilepsy and neurodegeneration. Kainic acid (KA) administration in rodents is an experimental approach that induces status epilepticus (SE) and replicates many of the phenomenological features of human temporal lobe epilepsy (TLE)...
October 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29107200/the-association-of-psychosocial-variables-with-adherence-to-antiepileptic-drugs-in-patients-with-temporal-lobe-epilepsy
#7
Shan Wang, Cong Chen, Bo Jin, Linglin Yang, Yao Ding, Yi Guo, Yi Chen, Shuang Wang, Meiping Ding
OBJECTIVE: The aim of this study was to explore the association between psychosocial factors and adherence to antiepileptic drugs (AEDs) in patients with temporal lobe epilepsy (TLE). METHODS: This cross-sectional study was conducted with 123 individuals with TLE, admitted to our epilepsy center from December 2015 to May 2017. The participants completed standardized self-report questionnaires measuring medication adherence, anxiety, depression, and family and social support...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29105058/verbal-memory-decline-from-hippocampal-depth-electrodes-in-temporal-lobe-surgery-for-epilepsy
#8
Hanna Ljung, Arto Nordlund, Maria Strandberg, Johan Bengzon, Kristina Källén
OBJECTIVE: To explore whether patients with refractory mesial temporal lobe epilepsy risk aggravated verbal memory loss from intracranial electroencephalography (EEG) recording with longitudinal hippocampal electrodes in the language-dominant hemisphere. METHODS: A long-term neuropsychological follow-up (mean 61.5 months, range 22-111 months) was performed in 40 patients after ictal registration with left hippocampal depth electrodes (study group, n = 16) or no invasive EEG, only extracranial registration (reference group, n = 24)...
November 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29104261/neurochemical-changes-and-c-fos-mapping-in-the-brain-after-carisbamate-treatment-of-rats-subjected-to-lithium-pilocarpine-induced-status-epilepticus
#9
José Eduardo Marques-Carneiro, Astrid Nehlig, Jean-Christophe Cassel, Eduardo Ferreira Castro-Neto, Julia Julie Litzahn, Anne Pereira de Vasconcelos, Maria da Graça Naffah-Mazacoratti, Maria José da Silva Fernandes
The administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model. When treated with CRS, about 50% of rats undergoing LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of convulsive ones (commonly observed in TLE). The goal of this work was to determine some of the early changes that occur after CRS administration, as they could be involved in the insult- and epileptogenesis-modifying effects of CRS...
November 1, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29101217/epigenetic-histone-deacetylation-inhibition-prevents-the-development-and-persistence-of-temporal-lobe-epilepsy
#10
Sandesh D Reddy, Bryan C Clossen, Doodipala Samba Reddy
Epilepsy is a chronic brain disease characterized by repeated unprovoked seizures. Currently, no drug therapy exists for curing epilepsy or disease-modification in people at risk. Despite several emerging mechanisms, there have been few studies of epigenetic signaling in epileptogenesis, the process whereby a normal brain becomes progressively epileptic because of precipitating factors. Here, we report a novel role of histone deacetylation as critical epigenetic mechanism in epileptogenesis. Experiments were conducted using the histone deacetylase (HDAC) inhibitor sodium butyrate in the hippocampus kindling model of temporal lobe epilepsy (TLE), a classic model heavily used to approve drugs for treatment of epilepsy...
November 3, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29099058/diverse-effects-of-an-acetylcholinesterase-inhibitor-donepezil-on-hippocampal-neuronal-death-after-pilocarpine-induced-seizure
#11
Jeong Hyun Jeong, Bo Young Choi, A Ra Kho, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Sang Yup Lee, Hong Ki Song, Hui Chul Choi, Sang Won Suh
Epileptic seizures are short episodes of abnormal brain electrical activity. Many survivors of severe epilepsy display delayed neuronal death and permanent cognitive impairment. Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer's disease. However, the role of donepezil in seizure-induced hippocampal injury remains untested. Temporal lobe epilepsy (TLE) was induced by intraperitoneal injection of pilocarpine (25 mg/kg). Donepezil (2.5 mg/kg/day) was administered by gavage in three different settings: (1) pretreatment for three days before the seizure; (2) for one week immediately after the seizure; and (3) for three weeks from three weeks after the seizure...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29094314/volumetric-changes-in-hippocampal-subregions-and-memory-performance-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#12
Caihong Ji, Lujia Zhu, Cong Chen, Shuang Wang, Leilei Zheng, Hong Li
In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients (21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors (CA1) exhibited maximum atrophy...
November 1, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29093635/beneficial-effects-of-silibinin-against-kainic-acid-induced-neurotoxicity-in-the-hippocampus-in-vivo
#13
Sehwan Kim, Un Ju Jung, Yong-Seok Oh, Min-Tae Jeon, Hyung-Jun Kim, Won-Ho Shin, Jungwan Hong, Sang Ryong Kim
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have not been examined yet. In order to investigate the effects of silibinin against epileptic seizures, we used a relevant mouse model in which seizures are manifested as status epilepticus, induced by kainic acid (KA) treatment. Silibinin was injected intraperitoneally, starting 1 day before an intrahippocampal KA injection and continued daily until analysis of each experiment...
October 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29088985/anticonvulsant-effect-of-gentamicin-on-the-seizures-induced-by-kainic-acid
#14
Yuxiao Zhao, Ziyi Wang, Wenwen Lao, Ping Kuang, Nan Jiang, Tao Yin, Weide Lin, Hongyan Zhu, Yonghua Ji
OBJECTIVE:  Epilepsy is a chronic neurological disorder affecting approximately 0.5-2% of the population worldwide. Gentamicin (GM) is an aminoglycoside antibiotic used to treat several types of bacterial infections. We investigate whether the administration of GM can reduce seizures in temporal lobe epilepsy (TLE). METHODS: The animal model of temporal lobe epilepsy (TLE) was established by kainic acid (KA) intrahippocampal injection. Behavioral test and Electroencephalography (EEG) recordings were performed to detect the effects of GM on the seizures triggered by KA injection in rats...
October 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/29080418/long-term-forgetting-in-temporal-lobe-epilepsy-is-this-phenomenon-a-norm
#15
Israel Contador, Abraham Sánchez, Michael D Kopelman, Jesús González de la Aleja
OBJECTIVES: This research investigated forgetting rates of patients with temporal lobe epilepsy (TLE) at brief and longer intervals. METHODS: The sample is formed by 5 patients with TLE and 10 healthy individuals. One of the patients received the diagnosis of transient epileptic amnesia (TEA). All patients underwent a standardized clinical protocol for diagnosis including a comprehensive neuropsychological assessment. In addition, two experimental tasks were used to assess the forgetting rates at 4 intervals (30s, 10min, 1day, and 1week): a story task to evaluate verbal cued recall and a route task to assess visuospatial cued recall...
October 25, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29080083/evaluation-of-metformin-effects-in-the-chronic-phase-of-spontaneous-seizures-in-pilocarpine-model-of-temporal-lobe-epilepsy
#16
Soraya Mehrabi, Nima Sanadgol, Mahmood Barati, Ali Shahbazi, Gelareh Vahabzadeh, Mitra Barzroudi, Morteza Seifi, Mazaher Gholipourmalekabadi, Fereshteh Golab
Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we have investigated the effects of metformin in the rat pilocaroin model of TLE. Male rats were treated with intra peritoneal injection of pilocarpine hydrochloride, in dose of 360 mg/kg to induce status epilepticus (SE). At 45 day after induction of SE, metformin was injected intraperitoneally in dose of 250 mg/kg/day for 5 days. We show that metformin potently reduces the progression of seizures and blocks seizure-induced over-expression of brain-derived neurotropic factor (BDNF) and its receptor, Tropomyosin receptor kinase B (TrkB)...
October 27, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29076425/cytotoxic-effects-and-production-of-cytokines-induced-by-the-endophytic-paenibacillus-polymyxa-rnc-d-in-vitro
#17
Débora Meira Neris, Genoveva Lourdes Flores Luna, Joice Margareth de Almeida Rodolpho, Ana Carolina Urbaczek, Ricardo de Oliveira Correia, Karina Alves Feitosa, Nadja Fernanda Gonzaga Serrano, Cristina Paiva de Sousa, Fernanda de Freitas Anibal
BACKGROUND: Prominent among all the organisms that have a potential value for the pro-duction of new medicines, are endophytes, fungi and bacteria that live inside plants without harming them. In this study, a total lyophilized extract (TLE) of Paenibacillus polymyxa RNC-D was used. The P. polymyxa lineages are known for their capacity to segregate a large number of extracellular enzymes and bioactive substances. METHODS: The TLE of Paenibacillus polymyxa RNC-D was tested in cell viability assays for cytotoxicity and cytokine production in BALB/3T3 and J774A...
October 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29075561/using-machine-learning-to-classify-temporal-lobe-epilepsy-based-on-diffusion-mri
#18
John Del Gaizo, Neda Mofrad, Jens H Jensen, David Clark, Russell Glenn, Joseph Helpern, Leonardo Bonilha
BACKGROUND: It is common for patients diagnosed with medial temporal lobe epilepsy (TLE) to have extrahippocampal damage. However, it is unclear whether microstructural extrahippocampal abnormalities are consistent enough to enable classification using diffusion MRI imaging. Therefore, we implemented a support vector machine (SVM)-based method to predict TLE from three different imaging modalities: mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA). While MD and FA can be calculated from traditional diffusion tensor imaging (DTI), MK requires diffusion kurtosis imaging (DKI)...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29075252/carbon-allocation-in-rhodococcus-jostii-rha1-in-response-to-disruption-and-overexpression-of-nlpr-regulatory-gene-based-on-13-c-labeling-analysis
#19
Martín A Hernández, Gerd Gleixner, Dirk Sachse, Héctor M Alvarez
Nitrogen lipid regulator (NlpR) is a pleiotropic regulator that positively controls genes associated with both nitrogen and lipid metabolism in the oleaginous bacterium Rhodococcus jostii RHA1. In this study, we investigated the effect of nlpR disruption and overexpression on the assimilation of (13)C-labeled glucose as carbon source, during cultivation of cells under nitrogen-limiting and nitrogen-rich conditions, respectively. Label incorporation into the total lipid extract (TLE) fraction was about 30% lower in the mutant strain in comparison with the wild type strain under low-nitrogen conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29074125/status-epilepticus-triggers-long-lasting-activation-of-complement-c1q-c3-signaling-in-the-hippocampus-that-correlates-with-seizure-frequency-in-experimental-epilepsy
#20
Nicole D Schartz, Season K Wyatt-Johnson, Lauren R Price, Samantha A Colin, Amy L Brewster
Status epilepticus (SE) triggers a myriad of neurological alterations that include unprovoked seizures, temporal lobe epilepsy (TLE), and cognitive deficits. Although SE-induced loss of hippocampal dendritic structures and synaptic remodeling are often associated with this pathophysiology, the underlying mechanisms remain elusive. Recent evidence points to the classical complement pathway as a potential mechanism. Signaling through the complement protein C1q to C3, which is cleaved into smaller biologically active fragments including C3b and iC3b, contributes to the elimination of synaptic structures in the normal developing brain and in models of neurodegenerative disorders...
October 23, 2017: Neurobiology of Disease
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