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https://www.readbyqxmd.com/read/27932302/hippocampal-asymmetry-differences-in-the-left-and-right-hippocampus-proteome-in-the-rat-model-of-temporal-lobe-epilepsy
#1
Leila Sadeghi, Albert Anatolyevich Rizvanov, Ilnur Ildusovich Salafutdinov, Bahareh Dabirmanesh, Mohammad Sayyah, Yaghoub Fathollahi, Khosro Khajeh
: The hippocampus is a complex brain structure and undergoes severe sclerosis and gliosis in temporal lobe epilepsy (TLE) as the most common type of epilepsy. The key features of the TLE may be reported in chronic animal models of epilepsy, such as pilocarpine model. Therefore, the current study was conducted in a rat pilocarpine model of acquired epilepsy. Two-dimensional gel electrophoresis based proteomic technique was used to compare the proteome map of the left and right hippocampus in both control and epileptic rats...
December 5, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27929068/evolution-of-the-net-noca-nlz-elbow-tlp-1-protein-family-in-metazoans-insights-from-expression-data-and-phylogenetic-analysis
#2
Filipe Pereira, Sara Duarte-Pereira, Raquel M Silva, Luís Teixeira da Costa, Isabel Pereira-Castro
The NET (for NocA, Nlz, Elbow, TLP-1) protein family is a group of conserved zinc finger proteins linked to embryonic development and recently associated with breast cancer. The members of this family act as transcriptional repressors interacting with both class I histone deacetylases and Groucho/TLE co-repressors. In Drosophila, the NET family members Elbow and NocA are vital for the development of tracheae, eyes, wings and legs, whereas in vertebrates ZNF703 and ZNF503 are important for the development of the nervous system, eyes and limbs...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924527/cognitive-functioning-in-temporal-lobe-epilepsy-a-bold-fmri-study
#3
Lili Guo, Genji Bai, Hui Zhang, Daoyan Lu, Jiyong Zheng, Gang Xu
We aimed to analyze the association between resting-state functional magnetic resonance imaging (re-fMRI) and cognitive function (including language, executive, and memory functions) in temporal lobe epilepsy (TLE) patients, which will help to explore the mechanism of brain function in patients. 15 TLE patients and 15 non-TLE patients were recruited. All subjects underwent neuropsychological testing and memory functional evaluation. Changes in verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), full intelligence quotient (FIQ), and memory quotient (MQ) were compared between two groups...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27905510/remarkable-alterations-of-nav1-6-in-reactive-astrogliosis-during-epileptogenesis
#4
Hongyan Zhu, Yuxiao Zhao, Hao Wu, Nan Jiang, Ziyi Wang, Weide Lin, Jiahui Jin, Yonghua Ji
Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical induction of status epilepticus (SE). To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct animal models of temporal lobe epilepsy (TLE) including a post-SE model induced by kainic acid (KA) intrahippocampal injection and a kindling model evoked by pentylenetetrazole (PTZ)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897304/-the-role-of-diffusion-tensor-imaging-in-the-pre-surgical-study-of-temporal-lobe-epilepsy
#5
M A Garcia-Pallero, C V Torres, R Manzanares-Soler, E Camara, R G Sola
INTRODUCTION: Diffusion tensor imaging (DTI) is a non-invasive technique that can be used to assess the integrity of the white matter in the brain. AIMS: To investigate the usefulness of DTI in patients with temporal lobe epilepsy (TLE) and to observe its relationship with lateralisation of the epileptogenic focus in these patients. PATIENTS AND METHODS: We analysed 11 patients diagnosed with TLE in accordance with the pre-surgical protocol of our epilepsy unit, and who were seizure-free two years after performing a temporal lobectomy plus amygdalohippocampectomy (Spencer technique)...
December 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27888083/clinical-and-imaging-evaluation-of-the-transuncus-selective-amygdalo-hippocampectomy
#6
Enrico Ghizoni, Roger Matias, Stefan Lieber, Brunno Machado de Campos, Clarissa Lin Yasuda, João Paulo Sant Ana Santos de Souza, Pamela Castro Pereira, Augusto Amato, Andrei Fernandes Joaquim, Tátila Martins Lopes, Helder Tedeschi, Fernando Cendes
BACKGROUND: Various reports described the transuncus approach (TU) as a selective route to the amygdala and hippocampus, but this approach has not yet being submitted to a solid post operative imaging analysis. The objective of this study was to evaluate the anatomy, surgical technique, postoperative imaging analysis and outcome in a series of temporal lobe epilepsy (TLE) patients who underwent to selective amigdalo-hippocampectomy (SHA) via TU. METHODS: This is a prospective study of 25 consecutive patients who underwent to selective amigdalo-hippocampectomy through TU...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27873133/altered-expression-of-cxcl13-and-cxcr5-in-intractable-temporal-lobe-epilepsy-patients-and-pilocarpine-induced-epileptic-rats
#7
Ruohan Li, Limin Ma, Hao Huang, Shu Ou, Jinxian Yuan, Tao Xu, Xinyuan Yu, Xi Liu, Juan Yang, Yangmei Chen, Xi Peng
The mechanisms that underlie the pathogenesis of epilepsy are still unclear. Recent studies have indicated that inflammatory processes occurring in the brain are involved in a common and crucial mechanism in epileptogenesis. C-X-C motif chemokine ligand 13 (CXCL13) and its only receptor, C-X-C motif chemokine receptor 5 (CXCR5), are highly expressed in the central nervous system (CNS) and participate in inflammatory responses. The present study aimed to assess the expression of CXCL13 and CXCR5 in the brain tissues of both patients with intractable epilepsy (IE) and a rat model (lithium-pilocarpine) of temporal lobe epilepsy (TLE) to identify possible roles of the CXCL13-CXCR5 signaling pathway in epileptogenesis...
November 21, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27873132/mechanisms-of-excessive-extracellular-glutamate-accumulation-in-temporal-lobe-epilepsy
#8
Jan Albrecht, Magdalena Zielińska
There is compelling evidence that initiation and maintenance of epileptic seizures in temporal lobe epilepsy (TLE) is facilitated by excessive accumulation in the extracellular (perisynaptic) space of the excitatory neurotransmitter glutamate (Glu). This review discusses the mechanisms underlying this phenomenon. Glu released from neurons is taken up by astrocytes and activated there by glutamine synthetase (GS) to form glutamine (Gln) which upon entry to neurons is degraded back to Glu by phosphate-activated glutaminase (PAG): this chain of reactions has been defined as the glutamine/glutamate/cycle (GGC)...
November 21, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27872690/the-effects-of-kainic-acid-induced-seizure-on-gene-expression-of-brain-neurotransmitter-receptors-in-mice-using-rt-2-pcr-array
#9
Taghi Naserpour Farivar, Marjan Nassiri-Asl, Pouran Johari, Reza Najafipour, Farid Hajiali
INTRODUCTION: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes in the gene expression of brain neurotransmitter receptors one week after administration of kainic acid in the mouse hippocampus...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27866308/establishing-a-mathematical-equations-and-improving-the-production-of-l-tert-leucine-by-uniform-design-and-regression-analysis
#10
Wei Jiang, Chao-Zhen Xu, Si-Zhi Jiang, Tang-Duo Zhang, Shi-Zhen Wang, Bai-Shan Fang
L-tert-Leucine (L-Tle) and its derivatives are extensively used as crucial building blocks for chiral auxiliaries, pharmaceutically active ingredients, and ligands. Combining with formate dehydrogenase (FDH) for regenerating the expensive coenzyme NADH, leucine dehydrogenase (LeuDH) is continually used for synthesizing L-Tle from α-keto acid. A multilevel factorial experimental design was executed for research of this system. In this work, an efficient optimization method for improving the productivity of L-Tle was developed...
November 19, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27864929/temporal-lobe-epilepsy-and-focal-cortical-dysplasia-in-children-a-tip-to-find-the-abnormality
#11
Luca Bartolini, Matthew T Whitehead, Cheng-Ying Ho, Leigh N Sepeta, Chima O Oluigbo, Kathryn Havens, Emily R Freilich, John M Schreiber, William D Gaillard
OBJECTIVE: To demonstrate an association between magnetic resonance imaging (MRI) findings and pathologic characteristics in children who had surgery for medically refractory epilepsy due to focal cortical dysplasia (FCD). METHODS: We retrospectively studied 110 children who had epilepsy surgery. Twenty-seven patients with FCD were included. Thirteen had temporal lobe epilepsy (TLE) and 14 had extra-temporal lobe epilepsy (ETLE). Three patients had associated mesial temporal sclerosis...
November 16, 2016: Epilepsia
https://www.readbyqxmd.com/read/27864825/individual-hippocampal-subfield-assessment-indicates-that-matrix-macromolecules-and-gliosis-are-key-elements-for-the-increased-t2-relaxation-time-seen-in-temporal-lobe-epilepsy
#12
Jose Eduardo Peixoto-Santos, Ludmyla Kandratavicius, Tonicarlo Rodrigues Velasco, Joao Alberto Assirati, Carlos Gilberto Carlotti, Renata Caldo Scandiuzzi, Carlos Ernesto Garrido Salmon, Antonio Carlos Dos Santos, Joao Pereira Leite
OBJECTIVE: Increased T2 relaxation time is often seen in temporal lobe epilepsy (TLE) with hippocampal sclerosis. Water content directly affects the effective T2 in a voxel. Our aim was to evaluate the relation between T2 values and two molecules associated with brain water homeostasis aquaporin 4 (AQP4) and chondroitin sulfate proteoglycan (CSPG), as well as cellular populations in the hippocampal region of patients with TLE. METHODS: Hippocampal T2 imaging and diffusion tensor imaging (DTI) were obtained from 42 drug-resistant patients with TLE and 20 healthy volunteers (radiologic controls, RCs)...
November 18, 2016: Epilepsia
https://www.readbyqxmd.com/read/27852925/anticodon-like-binding-of-the-hiv-1-trna-like-element-to-human-lysyl-trna-synthetase
#13
Sheng Liu, Roopa Comandur, Christopher P Jones, Pearl Tsang, Karin Musier-Forsyth
A critical step in the HIV-1 lifecycle involves reverse transcription of the viral genomic RNA (gRNA). Human tRNA(Lys3) serves as a primer for transcription initiation and is selectively enriched in virus particles. Human lysyl-tRNA synthetase (hLysRS) is also packaged into virions. Recently, a tRNA-like element (TLE) within the HIV-1 gRNA was shown to mimic the global tRNA fold and bind competitively to hLysRS, suggesting a mechanism of tRNA targeting to the primer binding site (PBS) and release from the synthetase...
December 2016: RNA
https://www.readbyqxmd.com/read/27852797/modulation-of-mir-146a-complement-factor-h-mediated-inflammatory-responses-in-a-rat-model-of-temporal-lobe-epilepsy
#14
Fang He, Bei Liu, Qiang Meng, Yang Sun, Weiwen Wang, Chao Wang
Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory RNA molecules that have been shown to act as negative regulators of gene expression controlling different biological processes, including immune-system homeostasis and function. We investigated the expression and cellular distribution of miRNA-146a (miR-146a) in a rat model of TLE. Prominent upregulation of miR-146a activation was evident at 1 week after status epilepticus (SE) and persisted in the chronic phase...
November 16, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27852056/tle1-function-and-therapeutic-potential-in-cancer
#15
REVIEW
Da Yuan, Xue Yang, Zhenpeng Yuan, Yanqing Zhao, Junchao Guo
Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27833066/activations-in-temporal-areas-using-visual-and-auditory-naming-stimuli-a-language-fmri-study-in-temporal-lobe-epilepsy
#16
Gloria G Gonzálvez, Karin Trimmel, Anja Haag, Louis A van Graan, Matthias J Koepp, Pamela J Thompson, John S Duncan
OBJECTIVE: Verbal fluency functional MRI (fMRI) is used for predicting language deficits after anterior temporal lobe resection (ATLR) for temporal lobe epilepsy (TLE), but primarily engages frontal lobe areas. In this observational study we investigated fMRI paradigms using visual and auditory stimuli, which predominately involve language areas resected during ATLR. METHODS: Twenty-three controls and 33 patients (20 left (LTLE), 13 right (RTLE)) were assessed using three fMRI paradigms: verbal fluency, auditory naming with a contrast of auditory reversed speech; picture naming with a contrast of scrambled pictures and blurred faces...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27816897/epileptic-networks-in-patients-with-bitemporal-epilepsy-the-role-of-seeg-for-the-selection-of-good-surgical-candidates
#17
REVIEW
L Di Vito, F Mauguière, H Catenoix, S Rheims, P Bourdillon, A Montavont, J Isnard
OBJECTIVE: In this study we investigated the electrical characteristics of seizures recorded by stereo-EEG (SEEG) in a cohort of patients with bitemporal lobe epilepsy (BTLE), in the attempt to verify the presence/absence of different seizure patterns and to identify good surgical candidates. METHODS: We retrospectively reviewed 14 consecutive patients with medically refractory BTLE confirmed by scalp video-EEG (VEEG) recording of bitemporal independent or non-lateralizing seizure onset...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27814647/role-of-jnk-isoforms-in-the-kainic-acid-experimental-model-of-epilepsy-and-neurodegeneration
#18
Carme Auladell, Luisa de Lemos, Ester Verdaguer, Miren Ettcheto, Oriol Busquets, Alberto Lazarowski, Carlos Beas-Zarate, Jordi Olloquequi, Jaume Folch, Antoni Camins
Chemoconvulsants that induce status epilepticus in rodents have been widely used over the past decades due to their capacity to reproduce with high similarity neuropathological and electroencephalographic features observed in patients with temporal lobe epilepsy (TLE). Kainic acid  is one of the most used chemoconvulsants in experimental models. KA administration mainly induces neuronal loss in the hippocampus. We focused the present review inthe c-Jun N-terminal kinase-signaling pathway (JNK), since it has been shown to play a key role in the process of neuronal death following KA activation...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27807516/the-morphological-and-functional-effects-of-exercise-in-the-aquatic-environment-performed-before-and-or-after-sciatic-nerve-compression-in-wistar-rats
#19
Camila Mayumi Martin Kakihata, Jéssica Aline Malanotte, Jhenifer Karvat, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro, Gladson Ricardo Flor Bertolini
The aim of this study was to evaluate the effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats on morphological and functional parameters. Twenty-five Wistar rats were divided into the following groups: control (C), lesion (L), trained+lesion (TL), lesion+exercise (LE), and training+lesion+exercise (TLE), who underwent right sciatic nerve compression on day 21 of the experiment. The TL and TLE groups were submitted to a jumping exercise in a water environment for 20 days prior to injury and the LE and TLE groups after injury...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27789303/stone-attenuation-values-measured-by-average-hounsfield-units-and-stone-volume-as-predictors-of-total-laser-energy-required-during-ureteroscopic-lithotripsy-using-holmium-yttrium-aluminum-garnet-lasers
#20
Mitsuo Ofude, Takashi Shima, Satoshi Yotsuyanagi, Daisuke Ikeda
OBJECTIVE: To evaluate the predictors of the total laser energy (TLE) required during ureteroscopic lithotripsy (URS) using the holmium:yttrium-aluminum-garnet (Ho:YAG) laser for a single ureteral stone. MATERIALS AND METHODS: We retrospectively analyzed the data of 93 URS procedures performed for a single ureteral stone in our institution from November 2011 to September 2015. We evaluated the association between TLE and preoperative clinical data, such as age, sex, body mass index, and noncontrast computed tomographic findings, including stone laterality, location, maximum diameter, volume, stone attenuation values measured using average Hounsfield units (HUs), and presence of secondary signs (severe hydronephrosis, tissue rim sign, and perinephric stranding)...
October 24, 2016: Urology
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