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https://www.readbyqxmd.com/read/28938604/inflammation-and-stem-markers-association-to-pim1-pim2-kinase-induced-tumors-in-breast-and-uterus
#1
Manuel-Pedro Jiménez-García, Antonio Lucena-Cacace, María-José Robles-Frías, Irene Ferrer, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of Ser/Thr kinase proteins has been implicated in tumorigenesis at different levels. PIM proteins are overexpressed in several tumor types and have been associated with chemoresistance. However, their role in hormone-dependent female tissues has not been explored, especially in the uterus, breast and ovary. We generated conditional transgenic mice with confined expression of human PIM1 or PIM2 genes in these tissues. We characterized the tumoral response to these genetic alterations corroborating their role as oncogenes since they induce hyperproliferation in all tissues and tumors in mammary gland and uterus...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28926107/fenofibrate-reverses-changes-induced-by-high-fat-diet-on-metabolism-in-mice-muscle-and-visceral-adipocytes
#2
Flávia de Toledo Frias, Karina Cunha E Rocha, Mariana de Mendonça, Gilson Massahiro Murata, Hygor Nunes Araujo, Luís Gustavo Oliveira de Sousa, Érica de Souza, Sandro Massao Hirabara, Nayara de Carvalho Leite, Everardo Magalhães Carneiro, Rui Curi, Leonardo Reis Silveira, Alice Cristina Rodrigues
The effect of fenofibrate on the metabolism of skeletal muscle and visceral white adipose tissue of diet-induced obese (DIO) mice was investigated. C57BL/6J male mice were fed either a control or high-fat diet for eight weeks. Fenofibrate (50 mg/Kg b.w., daily) was administered by oral gavage during the last two weeks of the experimental period. Insulin-stimulated glucose metabolism in soleus muscles, glucose tolerance test, insulin tolerance test, indirect calorimetry, lipolysis of visceral white adipose tissue, expression of miR-103-3p in adipose tissue and miR-1a, miR-133a/b, miR-206, let7b-5p, miR-23b-3p, miR-29-3p, miR-143-3p in soleus muscle, genes related to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were investigated...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28922580/accuracy-of-the-defining-characteristics-of-the-nursing-diagnosis-hypothermia-in-newborns
#3
Wislla Ketlly Menezes de Aquino, Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva, Nathaly Bianka Moraes Fróes, Angélica Paixão de Menezes, Aline de Aquino Peres Almeida, Bianca Alves Sobreira
PURPOSE: To analyze the accuracy of the defining characteristics of hypothermia in newborns and to verify associations between defining characteristics and clinical variables. METHODS: A cross-sectional accuracy study with statistical analysis. FINDINGS: Slow capillary refill, decrease in ventilation, peripheral vasoconstriction, and insufficient weight gain were the defining characteristics with the highest specificity values, while slow gastric emptying, skin cool to touch, irritability, and bradycardia were the defining characteristics with the highest values for both sensitivity and specificity...
September 18, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28895536/impact-of-kitchen-organization-on-oral-intake-of-malnourished-inpatients-a-two-center-study
#4
Alicia Calleja-Fernández, Cristina Velasco-Gimeno, Alfonso Vidal-Casariego, Begoña Pintor-de-la-Maza, Laura Frías-Soriano, Rocío Villar-Taibo, Pilar García-Peris, Isidoro Cano-Rodríguez, Camino García-Fernández, María D Ballesteros-Pomar
AIM: To determine the impact of the type of hospital kitchen on the dietary intake of patients. METHODS: A cross-sectional, two-centre study, of cooking in a traditional kitchen (TK) and in a chilled kitchen (CK). Subjective global assessment (SGA) was used for nutritional diagnosis. Before study start, a dietician performed a nutritional assessment of the menus of each hospital. All dishes were weighed upon arrival to the ward and at the end of the meal. RESULTS: 201 and 41 patients from the centres with TK and CK respectively were evaluated...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28892129/invariant-natural-killer-t-cell-development-and-function-with-loss-of-microrna-155
#5
Adolfo B Frias, Heather M Buechel, Arpan Neupane, Louise M D'Cruz
Invariant Natural Killer T (iNKT) cells are adaptive T cells with innate-like characteristics including rapid cytokine production and proliferative response to stimulation. Development of these cells in the thymus is dependent on expression of the microRNA (miRNA) processing enzyme Dicer indicating iNKT cells likely have distinct miRNA requirements for gene regulation during development. The miRNA, miR-155, has previously been shown to have numerous roles in T cells, including regulation of proliferation and differentiation and positive modulation of IFN-γ expression...
September 11, 2017: Immunology
https://www.readbyqxmd.com/read/28873045/gadolinium-chelate-safety-in-pregnancy-barely-detectable-gadolinium-levels-in-the-juvenile-nonhuman-primate-after-in-utero-exposure
#6
Joao Prola-Netto, Mark Woods, Victoria H J Roberts, Elinor L Sullivan, Christina Ann Miller, Antonio E Frias, Karen Y Oh
Purpose To determine whether gadolinium remains in juvenile nonhuman primate tissue after maternal exposure to intravenous gadoteridol during pregnancy. Materials and Methods Gravid rhesus macaques and their offspring (n = 10) were maintained, as approved by the institutional animal care and utilization committee. They were prospectively studied as part of a pre-existing ongoing research protocol to evaluate the effects of maternal malnutrition on placental and fetal development. On gestational days 85 and 135, they underwent placental magnetic resonance imaging after intravenous gadoteridol administration...
September 4, 2017: Radiology
https://www.readbyqxmd.com/read/28859102/factors-associated-with-last-dental-visit-or-not-to-visit-the-dentist-by-brazilian-adolescents-a-population-based-study
#7
Emílio P da Fonseca, Antonio C Frias, Fábio L Mialhe, Antonio C Pereira, Marcelo de C Meneghim
OBJECTIVES: We investigated the factors associated with no dental visit within the last two years by adolescents in the state of São Paulo, Brazil, by using data from the Oral Health Conditions of São Paulo state population Project (SBSP-2015) conducted in 2015. METHODS: This was a cross-sectional epidemiological study with a representative sample of adolescents aged 15 to higher years residing in São Paulo State. The examiners were calibrated and dental visits were measured categorically as 1- Less than 1 year, 2- One to two years, 3 - Three years or more, 4- I have never visited the dentist...
2017: PloS One
https://www.readbyqxmd.com/read/28857451/effect-of-ertugliflozin-on-glucose-control-body-weight-blood-pressure-and-bone-density-in-type-2-diabetes-mellitus-inadequately-controlled-on-metformin-monotherapy-vertis-met
#8
Julio Rosenstock, Juan Frias, Dénes Páll, Bernard Charbonnel, Raluca Pascu, Didier Saur, Amanda Darekar, Susan Huyck, Harry Shi, Brett Lauring, Steven G Terra
INTRODUCTION: We evaluated efficacy and safety of ertugliflozin, an SGLT2 inhibitor, in type 2 diabetes mellitus (T2DM) inadequately controlled (HbA1c, 7.0-10.5%) on metformin monotherapy (≥1500 mg/day for ≥8 weeks). METHODS: Double-blind, 26-week, multicentre study with ongoing 78-week extension; 621 participants randomized 1:1:1 to placebo, ertugliflozin 5 or 15 mg/day. Primary endpoint: change from baseline in HbA1c at week 26. Secondary efficacy endpoints: change from baseline at week 26 in fasting plasma glucose (FPG), body weight, systolic/diastolic blood pressure (SBP/DBP); participants with HbA1c <7...
August 31, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28854934/social-vulnerability-and-factors-associated-with-oral-impact-on-daily-performance-among-adolescents
#9
Inara Pereira da Cunha, Antônio Carlos Pereira, Antônio Carlos Frias, Vladen Vieira, Marcelo de Castro Meneghim, Marília Jesus Batista, Karine Laura Cortellazzi, Jaqueline Vilela Bulgareli
BACKGROUND: Oral disorders may negatively affect the quality of life (QoL) of adolescents. To investigate how social vulnerability and oral-health status factors affect QoL in 15-19 years olds who participated in the "SB São Paulo 2015" state survey. METHODS: The relationship of several independent variables, namely Paulista Social Vulnerability Index (PSVI) score, gender, skin color, family income, age, untreated caries, tooth loss [determined by the Decayed, Missing, Filled-Teeth (DMF-T) index], toothache, periodontal condition [determined by the Community Periodontal Index (CPI)], and malocclusion (maxillary overjet, cross bite, or open bite) affect daily life, measured by the Oral Impacts on Daily Performance (OIDP) instrument...
August 30, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28833873/early-maladaptive-schemas-associated-with-dimensional-and-categorical-psychopathology-in-patients-with-borderline-personality-disorder
#10
Álvaro Frías, Sara Navarro, Carol Palma, Núria Farriols, Ferrán Aliaga, Ana Salvador, Elena Aluco, Bárbara Martínez, Laia Solves
OBJECTIVE: To ascertain the foundations for a schema-focused therapy model for the treatment of borderline personality disorder. METHODS: The sample consisted of 102 borderline personality disorder outpatients. Dimensional psychopathology was assessed using the Scale for Suicidal Ideation, the Aggression Questionnaire, and the Symptom CheckList Revised. Categorical psychopathology was measured using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders, Patient Edition...
August 17, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28833584/binding-mode-and-selectivity-of-a-scorpiand-like-polyamine-ligand-to-single-and-double-stranded-dna-and-rna-metal-and-ph-driven-modulation
#11
Mario Inclán, Lluis Guijarro, Isabel Pont, Juan C Frias, Carmen Rotger, Francisca Orvay, Antoni Costa, Enrique Garcia-España, M Teresa Albelda Gimeno
The interaction of a polyazacyclophane ligand, having an ethylamine pendant arm functionalized with an anthryl group (L), with the ss-polynucleotides poly A, poly G, poly U and poly C as well as with the ds-polynucleotides poly A - poly U, poly (dAT)2 and poly (dGC)2 has been followed by UV-Vis, steady state fluorescence spectroscopy and thermal denaturation measurements. In the case of ss-polynucleotides, UV-Vis and fluorescence titrations permit to distinguish between sequences containing purine and pyrimidine bases...
August 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28832844/capturing-deaths-not-informed-to-the-ministry-of-health-proactive-search-of-deaths-in-brazilian-municipalities
#12
Wanessa da Silva de Almeida, Célia Landmann Szwarcwald, Paulo Germano de Frias, Paulo Roberto Borges de Souza, Raquel Barbosa de Lima, Dácio de Lyra Rabello, Juan José Cortez Escalante
Introduction: The proactive search of deaths is a strategy for capturing events that were not informed to the Mortality Information System of Ministry of Health. Its importance to reduce underreporting of deaths and to evaluate the operation of the information system is widely known. Objective: To describe the methodology and main findings of the Proactive Search of Deaths, 2013, establishing the contribution of different information sources. Methods: The research was carried out in 79 Brazilian municipalities...
April 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28832758/risk-factors-for-syphilis-in-women-case-control-study
#13
Vilma Costa de Macêdo, Pedro Israel Cabral de Lira, Paulo Germano de Frias, Luciana Maria Delgado Romaguera, Silvana de Fátima Ferreira Caires, Ricardo Arraes de Alencar Ximenes
OBJECTIVE: To determine the sociodemographic, behavioral, and health care factors related to the occurrence of syphilis in women treated at public maternity hospitals. METHODS: This is a case-control study (239 cases and 322 controls) with women admitted to seven maternity hospitals in the municipality of Recife, Brazil, from July 2013 to July 2014. Eligible women were recruited after the result of the VDRL (Venereal Disease Research Laboratory) under any titration...
August 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28832560/corrigendum-effects-of-growth-hormone-treatment-on-growth-plate-bone-and-mineral-metabolism-of-young-rats-with-uremia-induced-by-adenine
#14
Débora Claramunt, Helena Gil-Peña, Rocío Fuente, Enrique García-López, Olaya Hernández Frías, Flor A Ordoñez, Julián Rodríguez-Suárez, Fernando Santos
Pediatric Research accepted article preview online, 23 August 2017. doi:10.1038/pr.2017.205.
August 23, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28822051/new-basal-insulins-a-clinical-perspective-of-their-use-in-the-treatment-of-type-2-diabetes-and-novel-treatment-options-beyond-basal-insulin
#15
REVIEW
Patrick F Frias, Juan Pablo Frias
PURPOSE OF REVIEW: The purpose of this review was to review advances in basal insulin formulations and new treatment options for patients with type 2 diabetes not achieving glycemic targets despite optimized basal insulin therapy. RECENT FINDINGS: Advances in basal insulin formulations have resulted in products with increasingly favorable pharmacokinetic and pharmacodynamic properties, including flatter, peakless action profiles, less inter- and intra-patient variability, and longer duration of activity...
August 18, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28799976/effect-of-gene-gene-and-gene-environment-interactions-associated-with-antituberculosis-drug-induced-hepatotoxicity
#16
Julián G Chamorro, Jorge P Castagnino, Omar Aidar, Rosa M Musella, Ana Frías, Mabel Visca, Mabel Nogueras, Lucas Costa, Alessandro Perez, Fabio Caradonna, Gabriela F de Larrañaga
OBJECTIVES: This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires...
October 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28796309/formulation-characterization-and-stability-assessment-of-a-food-derived-tripeptide-leucine-lysine-proline-loaded-chitosan-nanoparticles
#17
Minna K Danish, Giuliana Vozza, Hugh J Byrne, Jesus M Frias, Sinéad M Ryan
The chicken- or fish-derived tripeptide, leucine-lysine-proline (LKP), inhibits the angiotensin converting enzyme and may be used as an alternative treatment for prehypertension. However, it has low permeation across the small intestine. The formulation of LKP into a nanoparticle (NP) has the potential to address this issue. LKP-loaded NPs were produced using an ionotropic gelation technique, using chitosan (CL113). Following optimization of unloaded NPs, a mixture amount design was constructed using variable concentration of CL113 and tripolyphosphate at a fixed LKP concentration...
August 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28791306/therapeutic-potential-of-epigallocatechin-gallate-nanodelivery-systems
#18
REVIEW
Andreia Granja, Iúri Frias, Ana Rute Neves, Marina Pinheiro, Salette Reis
Nowadays, the society is facing a large health problem with the rising of new diseases, including cancer, heart diseases, diabetes, neurodegenerative diseases, and obesity. Thus, it is important to invest in substances that enhance the health of the population. In this context, epigallocatechin gallate (EGCG) is a flavonoid found in many plants, especially in tea. Several studies support the notion that EGCG has several benefits in fighting cancer, heart diseases, diabetes, and obesity, among others. Nevertheless, the poor intestinal absorbance and instability of EGCG constitute the main drawback to use this molecule in prevention and therapy...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28782970/review-of-cold-war-freud-psychiatry-in-communist-europe-and-psiquiatr%C3%A3-a-psico%C3%A3-nalisis-y-cultura-comunista-batallas-ideol%C3%A3-gicas-en-la-guerra-fria-psychiatry-psychoanalysis-and-communist-culture-ideological-battles-in-the-cold-war
#19
Marco Innamorati
Reviews the books, Cold War Freud by D. Herzog (2016), Psychiatry in Communist Europe edited by M. Savelli and S. Marks (2015), and Psiquiatría, Psicoánalisis y Cultura Comunista: Batallas Ideológicas en la Guerra Fria [Psychiatry, psychoanalysis and communist culture: Ideological battles in the Cold War] by H. Vezzetti. On the whole, the three books show how the Cold War influenced, in various ways, psychiatric and psychotherapeutic cultures. Beyond the Iron Curtain, as one can perceive from the book edited by Savelli and Marks (2015), politics explicitly set the agenda for the psychological sciences, using them even to invent ad hoc nosologies, useful for purposes related to power...
August 2017: History of Psychology
https://www.readbyqxmd.com/read/28768173/the-sustained-effects-of-a-dual-gip-glp-1-receptor-agonist-nnc0090-2746-in-patients-with-type-2-diabetes
#20
Juan Pablo Frias, Edward J Bastyr, Louis Vignati, Matthias H Tschöp, Christophe Schmitt, Klara Owen, Rune Haubo Christensen, Richard D DiMarchi
Unimolecular dual incretins derived from hybridized glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) sequences have demonstrated synergistic reduction of adiposity in animal models and reductions of hyperglycemia in short-duration human trials. Here, we extend the characterization of NNC0090-2746 (also known as RG7697), a fatty-acylated dual agonist possessing in vitro balanced GIPR and GLP-1R agonism. In this 12-week, randomized, placebo-controlled, double-blind phase 2a trial, patients with type 2 diabetes inadequately controlled with metformin received 1...
August 1, 2017: Cell Metabolism
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