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https://www.readbyqxmd.com/read/29760780/derivative-chromosomes-involving-5p-large-rearranged-segments-went-unnoticed-with-the-use-of-conventional-cytogenetics
#1
Emiy Yokoyama, Victoria Del Castillo, Silvia Sánchez, Sandra Ramos, Bertha Molina, Leda Torres, María José Navarro, Silvia Avila, José Luis Castrillo, Benilde García-De Teresa, Bárbara Asch, Sara Frías
Background: In countries where comparative genomic hybridization arrays (aCGH) and next generation sequencing are not widely available due to accessibility and economic constraints, conventional 400-500-band karyotyping is the first-line choice for the etiological diagnosis of patients with congenital malformations and intellectual disability. Conventional karyotype analysis can rule out chromosomal alterations greater than 10 Mb. However, some large structural abnormalities, such as derivative chromosomes, may go undetected when the analysis is performed at less than a 550-band resolution and the size and banding pattern of the interchanged segments are similar...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29754207/acute-toxicity-of-ammonia-nitrite-and-nitrate-to-shrimp-litopenaeus-vannamei-postlarvae-in-low-salinity-water
#2
Gladys Valencia-Castañeda, Martin G Frías-Espericueta, Ruth C Vanegas-Pérez, Jesús A Pérez-Ramírez, María C Chávez-Sánchez, Federico Páez-Osuna
Shrimp farming in low salinities waters is an alternative to increasing production, and counteracting disease problems in brackish and marine waters. However, in low-salinity waters, toxicity of nitrogen compounds increases, and there is no available data of its acute toxicity in shrimp postlarvae. This study determined the acute toxicity of ammonia, nitrite and nitrate in Litopenaeus vannamei postlarvae in 1 and 3 g/L salinity, as well as the safety levels. The LC50 confirms that nitrite is more toxic than ammonia and nitrate in low salinity waters, and that its toxicity increases with a decrease in salinity...
May 12, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29751343/clavanin-a-bioconjugated-fe-3-o-4-silane-core-shell-nanoparticles-for-thermal-ablation-of-bacterial-biofilms
#3
Kalline L Ribeiro, Isaac A M Frías, Octavio L Franco, Simoni C Dias, Ailton A Sousa-Junior, Osmar N Silva, Andris F Bakuzis, Maria D L Oliveira, Cesar A S Andrade
The use of central venous catheters (CVC) is highly associated with nosocomial blood infections and its use largely requires a systematic assessment of benefits and risks. Bacterial contamination of these tubes is frequent and may result in development of microbial consortia also known as biofilm. The woven nature of biofilm provides a practical defense against antimicrobial agents, facilitating bacterial dissemination through the patient's body and development of antimicrobial resistance. In this work, the authors describe the modification of CVC tubing by immobilizing Fe3 O4 -aminosilane core-shell nanoparticles functionalized with antimicrobial peptide clavanin A (clavA) as an antimicrobial prophylactic towards Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29749491/expression-analysis-of-st3gal4-transcripts-in-cervical-cancer-cells
#4
Lorena Roa-de La Cruz, Patricia Martínez-Morales, Irene Morán-Cruz, Lorena Milflores-Flores, Nora Rosas-Murrieta, César González-Ramírez, Claudia Ortiz-Mateos, Ricardo Monterrosas-Santamaría, Celestina González-Frías, Carlos Rodea-Ávila, Teresa Apresa-García, Adriana Aguilar-Lemarroy, Luis Jave-Suarez, Gerardo Santos-López, Julio Reyes-Leyva, Verónica Vallejo-Ruiz
ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x). The present study evaluated the presence of three mRNA variants (V1, V2 and V3) in cervical cancer cell lines, detecting the three variants...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29738370/biologics-and-cardiovascular-disease
#5
John S Van Taunay, M Teresa Albelda, Juan Carlos Frias, Michael J Lipinski
The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations. Atherosclerosis, myocardial infarction, and heart failure have been closely linked to the inflammatory response. Accordingly, cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 have been targeted...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29732137/anaplasic-astrocytoma-with-exophytic-growth-in-sylvian-fissure-in-a-pediatric-patient-a-case-report
#6
José Raúl Guerra-Mora, Ulises Bravo-Ángel, Rodrigo Efraín Hernández-Reséndiz, Rosa María Vicuña-González, Jessica Frías-Guillén, Irina Jeanette Bercholc-Urinowsky, Carlos Cesar Bravo-Reyna, Ulises García-González
Gliomas are the most frequent supratentorial intracranial tumors in the pediatric population. Usually, they are intra-axial lesions with a characteristic image pattern, however, there are few reported cases of gliomas with exophytic growth. There are no previous reports in the literature of gliomas with exophytic growth in the Sylvian fissure. Fourteen year-old female patient who started with seizures. In imaging studies, a neoplasic mass with an exophytic portion in the left Sylvian fissure was found. Macroscopically, total resection was performed, definitive diagnosis was anaplastic astrocytoma...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29727732/luffa-operculata-fruit-aqueous-extract-induces-motor-impairments-anxiety-like-behavior-and-testis-damage-in-rats
#7
Cinthia Dos S Alves, Humberto V Frias, Thiago B Kirsten, Flora Cordeiro, Maria M Bernardi, Ivana B Suffredini
ETHNOPHARMACOLOGICAL RELEVANCE: Luffa operculata (L.) Cogn., Cucurbitaceae (buchinha-do-norte), aqueous extract (EBN) is popularly used to relieve symptoms of sinusitis and as abortive. AIM OF THE STUDY: As neurotoxicity and toxicity studies on the male reproductive system are scarce, the present study aimed at quantitatively addressing the question. MATERIALS AND METHODS: Male adult rats were observed in the open field (OF) and in the light-dark box test (LDB) to evaluate locomotion and anxiety...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29720634/blastocyst-like-structures-generated-solely-from-stem-cells
#8
Nicolas C Rivron, Javier Frias-Aldeguer, Erik J Vrij, Jean-Charles Boisset, Jeroen Korving, Judith Vivié, Roman K Truckenmüller, Alexander van Oudenaarden, Clemens A van Blitterswijk, Niels Geijsen
The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic tissues, including the placenta. It consists of a spherical thin-walled layer, known as the trophectoderm, that surrounds a fluid-filled cavity sheltering the embryonic cells 1 . From mouse blastocysts, it is possible to derive both trophoblast 2 and embryonic stem-cell lines 3 , which are in vitro analogues of the trophectoderm and embryonic compartments, respectively. Here we report that trophoblast and embryonic stem cells cooperate in vitro to form structures that morphologically and transcriptionally resemble embryonic day 3...
May 2018: Nature
https://www.readbyqxmd.com/read/29699769/papulopustular-rosacea-response-to-treatment-with-oral-azithromycin
#9
M Lova Navarro, P Sánchez-Pedreño Guillen, A M Victoria Martínez, T Martínez Menchón, R Corbalán Vélez, J Frías Iniesta
INTRODUCTION: Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option. MATERIAL AND METHOD: We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel...
April 23, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29689251/deregulated-psgl-1-expression-in-b-cells-and-dendritic-cells-may-be-implicated-in-human-systemic-sclerosis-development
#10
Javier Silván, Rafael González-Tajuelo, Esther Vicente-Rabaneda, Alicia Pérez-Frías, Marina Espartero-Santos, Antonio Muñoz-Cañejas, Elena García-Lorenzo, Carlos Gamallo, Santos Castañeda, Ana Urzainqui
Systemic sclerosis (SSc) is an autoimmune disorder with high morbidity and mortality, difficult early diagnosis and without curative treatment. PSGL-1 is a leukocyte receptor whose deficiency in mice promotes an SSc-like disease. ADAM8, a metalloprotease that cleaves PSGL-1, is implicated in inflammatory processes. Our goal was to evaluate whether PSGL-1 and ADAM8 contribute to the pathogenesis of human SSc. We found that patients with SSc presented increased PSGL-1 expression on monocytes, dendritic cells (DCs) and T cells, and decreased expression of PSGL-1 on B cells...
April 21, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29684535/sodium-caprate-enables-the-blood-pressure-lowering-effect-of-ile-pro-pro-and-leu-lys-pro-in-spontaneously-hypertensive-rats-by-indirectly-overcoming-pept1-inhibition
#11
John P Gleeson, Jesús M Frías, Sinéad M Ryan, David J Brayden
The tripeptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), inhibit angiotensin-converting enzyme (ACE) resulting in lowered blood pressure. Our hypothesis was that the medium chain fatty acid permeation enhancer, sodium caprate (C10 ), may prevent the decrease in permeability of the tripeptides when PepT1 is inhibited by glycyl-sarcosine (Gly-Sar), a situation that may occur in the presence of food hydrolysates. Using Caco-2 monolayers and isolated rat jejunal tissue, the apparent permeability coefficients (Papp ) of [3 H]-IPP and [3 H]-LKP were assessed in the presence of Gly-Sar with and without C10 ...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29683221/development-and-application-of-asymmetric-organocatalytic-mukaiyama-and-vinylogous-mukaiyama-type-reactions
#12
José Alemán, Alberto Garrido, Alberto Fraile, Francisco Yuste, Maria Frias, Wioleta Cieslik, Anielka Rosado
Organocatalysis is a growing area that is benefiting from advances in many fields. Its implementation has begun in areas such as supramolecular chemistry, organic chemistry and natural product syntheses. While a considerable number of important publications in the field of organocatalytic Mukaiyama-type additions have been reported, they are yet to be fully covered in a review. Therefore, we would like to highlight the applications of various kinds of organocatalysts in Mukaiyama-type reactions, while also including the vinylogous Mukaiyama variant...
April 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29679073/author-correction-machine-learning-for-the-meta-analyses-of-microbial-pathogens-volatile-signatures
#13
Susana I C J Palma, Ana P Traguedo, Ana R Porteira, Maria J Frias, Hugo Gamboa, Ana C A Roque
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29676854/effects-of-candidatus-liberibacter-solanacearum-haplotype-b-on-bactericera-cockerelli-fitness-and-vitellogenesis
#14
Angélica Albuquerque Tomilhero Frias, Freddy Ibanez, Azucena Mendoza, William Mario de Carvalho Nunes, Cecilia Tamborindeguy
'Candidatus Liberibacter solanacearum' (Lso) are phloem-restricted and unculturable gram-negative bacteria. Presently five haplotypes have been identified worldwide; but only haplotypes A and B are associated with the vector Bactericera cockerelli (Šulc.) in the Americas. Previous studies showed that Lso-infection reduces B. cockerelli reproductive output and that Lso haplotype B is more pathogenic than Lso haplotype A. To understand the interaction of Lso haplotype B and B. cockerelli, the fitness of Lso-free and Lso B-infected insects, and the expression of vitellogenin (BcVg1-like), a gene involved directly in the insect reproduction were analyzed...
April 20, 2018: Insect Science
https://www.readbyqxmd.com/read/29669837/amino-acid-substitutions-within-hla-b-27-restricted-t-cell-epitopes-prevent-recognition-by-hepatitis-delta-virus-specific-cd8-t-cells
#15
Hadi Karimzadeh, Muthamia M Kiraithe, Anna D Kosinska, Manuel Glaser, Melanie Fiedler, Valerie Oberhardt, Elahe Salimi Alizei, Maike Hofmann, Juk Yee Mok, Melanie Nguyen, Wim J E van Esch, Bettina Budeus, Jan Grabowski, Maria Homs, Antonella Olivero, Hossein Keyvani, Francisco Rodríguez-Frías, David Tabernero, Maria Buti, Andreas Heinold, Seyed Moayed Alavian, Tanja Bauer, Julian Schulze Zur Wiesch, Bijan Raziorrouh, Daniel Hoffmann, Antonina Smedile, Mario Rizzetto, Heiner Wedemeyer, Jörg Timm, Iris Antes, Christoph Neumann-Haefelin, Ulrike Protzer, Michael Roggendorf
Virus-specific CD8 T-cell response seems to play a significant role in the outcome of hepatitis delta virus (HDV) infection. However, the HDV-specific T-cell epitope repertoire and mechanisms of CD8 T-cell failure in HDV infection have merely been characterized. We therefore aimed to characterize HDV-specific CD8 T cell epitopes and the impact of viral mutations on immune escape. In this study, we predicted peptide epitopes binding the most frequent HLA types and assessed their HLA binding capacity. These epitopes were characterized in HDV-infected patients by intracellular IFN-γ staining...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29668813/factors-influencing-the-impact-of-oral-health-on-the-daily-activities-of-adolescents-adults-and-older-adults
#16
Jaqueline Vilela Bulgareli, Eduardo Tanajura de Faria, Karine Laura Cortellazzi, Luciane Miranda Guerra, Marcelo de Castro Meneghim, Glaucia Maria Bovi Ambrosano, Antonio Carlos Frias, Antonio Carlos Pereira
OBJECTIVE: Analyze if clinical, sociodemographic and access to dental services variables influence the impact of oral health on the daily activities of adolescents, adults and older adults. METHODS: A cross-sectional study with secondary data from the State Oral Health Survey (SB São Paulo 2015) conducted in 163 cities of São Paulo. A total of 17,560 individuals from three age groups: 15-19-year-old (n = 5,558), 35-44-year-old (n = 6,051), and older people of 65 years or more (n = 5,951) participated in the survey...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29659194/detection-of-hepatitis-e-virus-rna-in-saliva-for-diagnosis-of-acute-infection
#17
A Rivero-Juarez, M Frias, P Lopez-Lopez, A Martinez-Peinado, M Á Risalde, T Brieva, I Machuca, Á Camacho, I García-Bocanegra, J C Gomez-Villamandos, A Rivero
Diagnosis of acute hepatitis E virus (HEV) infection is established by detection of anti-HEV IgM antibodies by ELISA or by amplification of serum viral RNA. Here, we evaluate the diagnostic value of testing HEV RNA in saliva to identify patients with acute HEV infection. Prospective proof-of-concept study including patients with acute hepatitis. Whole blood and neat saliva samples were obtained from all patients. Saliva samples were processed and analysed for HEV RNA by RT-PCR within 2 hr after collection...
April 16, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29622220/individual-contributions-of-savinase-and-lactobacillus-plantarum-to-lentil-functionalization-during-alkaline-ph-controlled-fermentation
#18
Sara Bautista-Expósito, Elena Peñas, Montserrat Dueñas, José Manuel Silván, Juana Frias, Cristina Martínez-Villaluenga
Legumes offer the possibility to develop multifunctional foods with benefits for metabolic syndrome. Our objective was to study the effect of alkaline fermentation by Lactobacillus plantarum and Savinase (FLPS) as well the individual effects of both processes on peptides, phenolics and bioactivity of lentil. FLPS increased peptides and some flavonoids and enhanced antioxidant activity, inhibition of angiotensin I-converting enzyme (ACE) and intestinal maltase activities of lentil soluble fraction. Savinase contributed to peptide release, ACE inhibitory and antioxidant activities of lentil soluble fraction...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29608751/t2candida-mr-as-a-predictor-of-outcome-in-patients-with-suspected-invasive-candidiasis-starting-empirical-antifungal-treatment-a-prospective-pilot-study
#19
Patricia Muñoz, Antonio Vena, Marina Machado, Francesca Gioia, María Carmen Martínez-Jiménez, Elia Gómez, Julia Origüen, María Ángeles Orellana, Francisco López-Medrano, Mario Fernández-Ruiz, Paloma Merino, Fernando González-Romo, Isabel Frías, María-Jesús Pérez-Granda, José María Aguado, Jesús Fortún, Emilio Bouza
Objectives: We assessed the potential role of T2Candida MR (T2MR) and serological biomarkers [β-d-glucan (BDG) or Candida albicans germ tube antibodies (CAGTA)], alone or in combination with standard cultures, for identifying patients with suspected invasive candidiasis (IC), who may benefit from maintaining antifungal therapy. Methods: Prospective observational multicentre study including all adult patients receiving empirical antifungal therapy for suspected IC, from January to June 2017...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29607824/lymphoid-proliferation-in-eyelid-a-primary-follicular-lymphoma-case
#20
Deivy Cruzado-Sánchez, Walter Andree Tellez, Solon Serpa-Frias, Grisnery Maquera
Ocular adnexal lymphoma (OAL) constitutes 8% of all extranodal lymphomas, being rare in the eyelids (5-20%). The objective was to report a case of eyelid follicular lymphoma in a young adult woman. A 35-year-old female with swelling in left lower eyelid with development for 2 months. The visual acuity was 20/20 in both eyes, the tumor mass was 3 cm wide and 1.5 cm long. The contrast-enhanced computed tomography showed a soft-tissue injury in the left lower eyelid but had no signs of local spread according to description...
January 2018: Gulf Journal of Oncology
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