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https://www.readbyqxmd.com/read/29136193/early-first-trimester-uteroplacental-flow-and-the-progressive-disintegration-of-spiral-artery-plugs-new-insights-from-contrast-enhanced-ultrasound-and-tissue-histopathology
#1
V H J Roberts, T K Morgan, P Bednarek, M Morita, G J Burton, J O Lo, A E Frias
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believed. WHAT IS KNOWN ALREADY: During placental establishment and remodeling of maternal spiral arteries, endovascular trophoblast cells invade and accumulate in the lumen of these vessels to form 'trophoblast plugs'...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29133065/-functional-tricuspid-regurgitation-and-apical-hypertrophic-cardiomyopathy-diagnostic-and-therapeutic-strategy-regarding-a-clinical-case
#2
Jesús Piqueras-Flores, Alfonso Jurado-Román, Pedro Pérez-Díaz, Ramón Maseda-Uriza, Germán Hernández-Herra, M Ángeles Pérez-Martínez, María Thiscal López-Lluva, Juan Antonio Requena-Ibáñez, Raquel Frías-García, Ignacio Sánchez-Pérez, Fernando Lozano-Ruiz-Poveda
No abstract text is available yet for this article.
November 10, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29132921/empirical-data-demonstrates-risk-tradeoffs-between-landscapes-for-herbivorous-fish-may-promote-reef-resilience
#3
Caitlin R Fong, Matthew Frias, Nicholas Goody, Sarah Joy Bittick, Rachel J Clausing, Peggy Fong
Herbivores balance resource requirements with predation risk, which can differ among landscapes; hence, landscape can shape these trade-offs, influencing herbivore distribution and behavior. While this paradigm has been well established on coral-dominated reefs, tropical reefs worldwide are shifting to algal dominance. If herbivores avoid algae due to higher risk and forage in coral, these algal states may be stabilized. However, if herbivores forage more in resource-rich algal states, this may promote coral recovery...
November 6, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29126749/corrigendum-to-efficacy-of-e2-glycoprotein-fused-to-porcine-cd154-as-a-novel-chimeric-subunit-vaccine-to-prevent-classical-swine-fever-virus-vertical-transmission-in-pregnant-sows
#4
Sara Muñoz-González, Yusmel Sordo, Marta Pérez-Simó, Marisela Suarez, Albert Canturri, Maria Pilar Rodriguez, María Teresa Frías-Lepoureau, Mariano Domingo, Mario Pablo Estrada, Llilianne Ganges
Here we evaluated the effect of double vaccination with a novel subunit marker vaccine candidate based in the CSFV E2 glycoprotein fused to the porcine CD154 to prevent CSFV vertical transmission. A lentivirus-based gene delivery system was used to obtain a stable recombinant HEK 293 cell line for the expression of E2 fused to porcine CD154 molecule. Six pregnant sows were distributed in two groups and at 64days of gestation animals numbered 1-4 (group 1) were vaccinated via intramuscular inoculation with 50μg of E2-CD154 subunit vaccine...
November 7, 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29117209/persistence-of-hepatitis-e-virus-in-the-liver-of-non-viremic-naturally-infected-wild-boar
#5
María A Risalde, Antonio Rivero-Juárez, Fernando Romero-Palomo, Mario Frías, Pedro López-López, David Cano-Terriza, Ignacio García-Bocanegra, Saúl Jiménez-Ruíz, Ángela Camacho, Isabel Machuca, José C Gomez-Villamandos, Antonio Rivero
Hepatitis E virus (HEV) is an emerging zoonotic pathogen with pigs and wild boar serving as reservoirs for human infection through direct contact with infected animals or the consumption of raw or undercooked pork products. The liver is considered the main target site of HEV replication in swine and an important organ in the pathogenesis of the disease. The aim of this study was to characterize the target liver cells for HEV entry in naturally infected wild boar and to evaluate the type and severity of the pathological changes in order to reach a better understanding of the hepatic pathogenic mechanisms involved in hepatitis E...
2017: PloS One
https://www.readbyqxmd.com/read/29111406/panic-like-escape-response-elicited-in-mice-by-exposure-to-co2-but-not-hypoxia
#6
Ailton Spiacci, Heloisa H Vilela-Costa, Ana Beatriz Sant'Ana, Gabriel Gripp Fernandes, Alana Tercino Frias, Glauber S Ferreira da Silva, José Antunes-Rodrigues, Hélio Zangrossi
Exposure to elevated concentrations of CO2 or hypoxia has been widely used in psychiatric research as a panic provoking stimulus. However, the use of these respiratory challenges to model panic-like responses in experimental animals has been less straightforward. Little data is available, from behavioral and endocrine perspectives, to support the conclusion that a marked aversive situation, such as that experienced during panic attacks, was evoked in these animals. We here compared the behavioral responses of male CB57BL/6 mice during exposure to 20% CO2 or 7% O2 and its consequence on plasma levels of corticosterone...
October 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29099112/enfermedad-de-castleman-an%C3%A3-lisis-histopatol%C3%A3-gico-e-inmunohistoqu%C3%A3-mico-de-39-casos
#7
Diana Brisa Sevilla-Lizcano, Christian Lizette Frias-Soria, Carlos Ortiz-Hidalgo
Introduction: Castleman disease (CD) is a rare lymphoproliferative that comprises two distinct clinical subtypes (unicentric and multicentric) and has two basic histopathology patterns that are hyaline-vascular (HV) and plasma-cell (PC) type. Some cases of multicentric PC disease are associated with HHV-8 infection. Objective: To present the histopathologic and immunohistochemical characteristics of 39 cases of CD. Methods: A review of cases with the diagnosis CD from the files of the Department of Pathology of the ABC Medical Centre in Mexico City was performed...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29093589/-practical-issues-in-diagnostic-tests-for-helicobacter-pylori-infection-a-narrative-review
#8
Juan Sebastián Frías Ordoñez, William Otero Regino
H. pylori diagnosis is important because of the different clinical conditions associated with its presence, taking into account the different recommended indications for Helicobacter pylori erradication therapy and the broad spectrum of available diagnostic methods, it is necessary to achieve a timely diagnosis before and after eradication therapy. The success in the diagnosis is obtained from methods with high precision, those whose sensitivity and specificity is greater than 90%. This article aims to present advances in the various methods related to its detection, emphasizing their contributions and possible defects...
July 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29076159/lichen-planus-pigmentosus-and-its-variants-review-and-update
#9
REVIEW
Juan Carlos Robles-Méndez, Paulina Rizo-Frías, Maira Elizabeth Herz-Ruelas, Amit G Pandya, Jorge Ocampo Candiani
Lichen planus pigmentosus (LPP) is considered a rare variant of lichen planus (LP). It is characterized by acquired dark brown to gray macular pigmentation located on sun-exposed areas of the face, neck, and flexures, commonly found in dark-skinned patients. In patients with LPP, an inflammatory lichenoid response results in marked pigmentary incontinence. It has been associated with hepatitis C virus, sun exposure, and contactants such as mustard oil and nickel. LPP-inversus affects fair and dark skin, predominantly involving flexural and intertriginous areas, while sun-exposed areas are spared; friction is an associated trigger...
October 26, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29053644/dental-approach-for-apert-syndrome-in-children-a-systematic-review
#10
A-S López-Estudillo, M-A Rosales-Bérber, S Ruiz-Rodríguez, A Pozos-Guillén, M-Á Noyola-Frías, A Garrocho-Rangel
BACKGROUND: Apert Syndrome (AS), or type I acrocephalosyndactyly, is a rare, congenital craniosynostosis condition resulting from missense mutations in the gene encoding fibroblast growth factor receptor 2. It is characterized by three specific clinical features: brachycephalic skull; midface hypoplasia, and limb abnormalities (syndactyly of hands and feet). The disorder exhibits variable presentations in bones, brain, skin, internal organs, and in the oral/maxillofacial region. The aim of the present paper was to show the main results from a systematic review of AS...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29049043/challenges-of-healthcare-administration-optimizing-quality-and-value-at-an-affordable-cost-in-pediatric-cardiology
#11
Mitchell I Cohen, Patricio A Frias
PURPOSE OF REVIEW: The purpose of this review is to explore the paradigm shift in healthcare delivery that will need to take place over the next few years away from an emphasis on supply-driven health care to better quality transparent-driven health care whose focus is on the consumer's best interest. RECENT FINDINGS: The current healthcare system is fragmented and costs continue to rise. The best way to contain costs is to improve quality to the consumer, the patient...
October 18, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29040484/esophagocardioplasty-vagotomy-antrectomy-and-roux-en-y-gastrojejunostomy-indication-in-cases-with-severe-esophageal-motor-disfunction
#12
I Braghetto, O Korn, A Csendes, J C Frias
Almost 10% of patients with Crest syndrome associated with severe gastroesophageal reflux and 5-10% of patients with failed cardiomyotomy for achalasia present with cardial or distal esophageal organic stricture. Some of these cases are poor risk patients for surgery and therefore the surgeon must offer a safe procedure with low morbimortality, keeping in mind the pathophysiological motor pattern of these patients.In order to treat the stricture to improve the esophageal transit we treated patients with esophagocardioplasty associated with vagotomy-antrectomy and Roux-en-Y gastrojejunostomy, thereby avoiding the potential acid or biliary reflux in poor risk patients in whom esophagectomy would be a very deleterious procedure...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040261/effects-of-growth-hormone-treatment-on-growth-plate-bone-and-mineral-metabolism-of-young-rats-with-uremia-induced-by-adenine
#13
Débora Claramunt, Helena Gil-Peña, Rocío Fuente, Enrique García-López, Olaya Hernández Frías, Flor A Ordoñez, Julián Rodríguez-Suárez, Fernando Santos
This corrects the article DOI: 10.1038/pr.2017.95.
November 2017: Pediatric Research
https://www.readbyqxmd.com/read/29038590/chronic-hepatitis-c-liver-microenvironment-role-of-the-th17-treg-interplay-related-to-fibrogenesis
#14
Daniela Alejandra Rios, Pamela Valva, Paola Cecilia Casciato, Silvia Frias, María Soledad Caldirola, María Isabel Gaillard, Liliana Bezrodnik, Juan Bandi, Omar Galdame, Beatriz Ameigeiras, Diana Krasniansky, Carlos Brodersen, Eduardo Mullen, Elena Noemí De Matteo, María Victoria Preciado
The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in adult CHC patients. CD4(+) lymphocytes were predominant in the liver, with high Foxp3(+) but low IL-17A(+) frequency. IL-17A(+) lymphocytes and IL-17A(+)/Foxp3(+) ratio displayed association with advanced fibrosis (p = 0...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035820/real-time-monitoring-of-amyloid-fibrillation-by-electrical-impedance-spectroscopy
#15
Rafael R da Silva, Sandro V de Lima, Helinando P de Oliveira, Celso P de Melo, Isaac A M Frías, Maria D L Oliveira, César A S Andrade
Electrical impedance spectroscopy (EIS) appears a promising label-free methodology for the investigation of processes related to the aggregation of macromolecules in solution. Here, we explore the EIS technique as a convenient tool for studying the irreversible aggregation of human insulin and describing its corresponding fibrillation kinetics. The in situ measurement of the electrical response of pure insulin solutions at 60°C allows for the real-time monitoring of the protein fibrillation as a function of the incubation time...
October 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29033884/commentary-psychological-science-s-aversion-to-the-null
#16
Jose D Perezgonzalez, Dolores Frías-Navarro, Juan Pascual-Llobell
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29032925/current-status-of-the-etiology-of-candidiasis-in-mexico
#17
María Del Rocío Reyes-Montes, Esperanza Duarte-Escalante, Erick Martínez-Herrera, Gustavo Acosta-Altamirano, María Guadalupe Frías-De León
This study presents a systematic review of the literature on the etiology of superficial and invasive candidiasis in Mexico reported from 2005 to 2015. The data have shown that Candida albicans is the most prevalent species with an increasing tendency of the non-C. albicans Candida species, as reported in other countries. The use of phenotypical methods in the identification of the yeasts limits the identification at the species level, particularly in species that are part of complexes, this is important because the identification only at the genus level leads to inadequate treatment due to the different susceptibility to the antifungals among species...
October 9, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29017058/androgen-receptor-pathway-independent-prostate-cancer-is-sustained-through-fgf-signaling
#18
Eric G Bluemn, Ilsa M Coleman, Jared M Lucas, Roger T Coleman, Susana Hernandez-Lopez, Robin Tharakan, Daniella Bianchi-Frias, Ruth F Dumpit, Arja Kaipainen, Alexandra N Corella, Yu Chi Yang, Michael D Nyquist, Elahe Mostaghel, Andrew C Hsieh, Xiaotun Zhang, Eva Corey, Lisha G Brown, Holly M Nguyen, Kenneth Pienta, Michael Ittmann, Michael Schweizer, Lawrence D True, David Wise, Paul S Rennie, Robert L Vessella, Colm Morrissey, Peter S Nelson
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often through neuroendocrine (NE) transdifferentiation. Through the molecular assessment of mPCs over two decades, we find a phenotypic shift has occurred in mPC with the emergence of an AR-null NE-null phenotype. These "double-negative" PCs are notable for elevated FGF and MAPK pathway activity, which can bypass AR dependence...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28994557/increasing-survival-of-metastatic-breast-cancer-through-locoregional-surgery
#19
Begoña Díaz de la Noval, Laura Frías Aldeguer, María Á Leal García, Enrique García López, Mariana Díaz Almirón, María Herrera de la Muela
BACKGROUND: Surgery for the primary tumor in metastatic breast cancer is usually not recommended, assuming that local therapy provides no advantage. Recent reports suggest a survival improvement after locoregional treatment, but this is still controversial. We aimed to evaluate the effectiveness of locoregional treatment in primary metastatic breast cancer and to determine associated factors. METHODS: A retrospective analysis of 39 women with de novo metastatic breast cancer at Hospital Universitario La Paz, from January-2012 to June-2016 grouped by locoregional treatment (n=23) or not (n=16)...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28988126/quantitative-characterization-of-hepatitis-delta-virus-genome-edition-by-next-generation-sequencing
#20
Sara Sopena, Cristina Godoy, David Tabernero, Maria Homs, Josep Gregori, Mar Riveiro-Barciela, Alicia Ruiz, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías
AIM: To determine the capacity of next-generation sequencing (NGS) for quantifying edited and unedited HDV populations, and to confirm if edition is a general phenomenon taking place along the entire HDV region analyzed, as we previously reported (Homs M et al. PLoS One 2016, 11, e0158557). METHODS: Four serum samples from 4 patients with chronic HDV/HBV infection were included in the study. The region selected for analysis covered 360 nucleotides (nt), positions 910-1270 of the HDV genome, which included the HDAg ORF editing site (nt 1014 within codon 196)...
October 4, 2017: Virus Research
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