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https://www.readbyqxmd.com/read/29330418/hla-b-hla-c-and-kir-improve-the-predictive-value-of-ifnl3-for-hepatitis-c-spontaneous-clearance
#1
Mario Frias, Antonio Rivero-Juárez, Diego Rodriguez-Cano, Ángela Camacho, Pedro López-López, María Ángeles Risalde, Bárbara Manzanares-Martín, Teresa Brieva, Isabel Machuca, Antonio Rivero
IFNL3 is the strongest predictor of spontaneous resolution (SR) of hepatitis C virus (HCV), however, consideration of IFNL3 genotype alone is of limited clinical value for the prediction of SR or chronic HCV infection. The objective of this study was to analyze the impact of HLA-B, HLA-C and KIRs on SR, as well as their additive effects on the predictive value of the IFNL3 genotype. We conducted a retrospective study of HIV patients that included both SR and chronic HCV patients. In our study, 61.6% of patients with IFNL3 CC achieved SR, and 81...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329853/ph-controlled-fermentation-in-mild-alkaline-conditions-enhances-bioactive-compounds-and-functional-features-of-lentil-to-ameliorate-metabolic-disturbances
#2
Sara Bautista-Expósito, Elena Peñas, José Manuel Silván, Juana Frias, Cristina Martínez-Villaluenga
Lentil fermentation has a promising potential as a strategy for development of multifunctional ingredients targeting metabolic syndrome (MetS). Response surface methodology was applied to optimize lentil fermentation and study its effects on generation of peptides, soluble phenolics and bioactivities. Fermentation using Lactobacillus plantarum and Savinase® 16 L was carried out at different pH (6.5-8.5) and times (5.5-30 h). Analysis of variance was performed to evaluate linear, quadratic and interaction effects between fermentation parameters...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#3
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29316164/effects-of-exenatide-once-weekly-plus-dapagliflozin-exenatide-once-weekly-or-dapagliflozin-added-to-metformin-monotherapy-on-body-weight-systolic-blood-pressure-and-triglycerides-in-patients-with-type-2-diabetes-in-the-duration-8-study
#4
Serge A Jabbour, Juan P Frías, Cristian Guja, Elise Hardy, Azazuddin Ahmed, Peter Öhman
This post hoc analysis assessed the effects on cardiovascular risk factors of body weight, systolic blood pressure (SBP), and triglycerides after 28 weeks' treatment with exenatide once weekly (QW) plus dapagliflozin, as compared with exenatide QW or dapagliflozin, in patient subpopulations from the DURATION-8 trial of patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin alone. Subgroups of patients were stratified according to their baseline body weight, SBP, and triglycerides...
January 5, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29314370/bioinspired-electro-organocatalytic-material-efficient-for-hydrogen-production
#5
Ruben Mas-Balleste, Octavio Gonzalez-Del Moral, Arnau Call, Federico Franco, Alicia Moya, Jose Antonio Nieto, María Frias, Jose L G Fierro, Miquel Costas, Julio Lloret-Fillol, José Alemán
Commercial carbon fibers can be used as electrodes with high conductive surfaces in reduced devices. Oxidative treatment of such electrodes results in a chemically robust material with high catalytic activity for electrochemical proton reduction, enabling the measurement of quantitative faradaic yields (>95%) and high current densities. Combination of experiments and theoretic calculations reveals that the presence of carboxylic groups triggers such electro-catalytic activity in a bioinspired manner. Analogously to the known Hantzsch esters, the oxidized carbon fiber material is able to transfer hydrides, which can react with protons generating H2 or with organic substrates resulting in their hydrogenation...
January 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29313398/a-15-year-review-of-secondary-and-tertiary-optic-nerve-sheath-fenestration-for-idiopathic-intracranial-hypertension
#6
Andrew J Anzeljc, Patrick Frias, Brent R Hayek, Nancy Canter Weiner, Ted H Wojno, H Joon Kim
PURPOSE: Optic nerve sheath fenestration (ONSF) is a common surgical option for patients with idiopathic intracranial hypertension (IIH) with vision loss refractory to medical management. Little is known about the visual benefit of repeated ONSF. The authors aimed to assess the efficacy of secondary and tertiary ONSF in patients with IIH. METHODS: A retrospective chart review was performed on all patients with repeat ONSF for IIH at Emory University from 1999 to 2016...
January 9, 2018: Orbit
https://www.readbyqxmd.com/read/29311336/troy-brain-stem-cells-cycle-through-quiescence-and-regulate-their-number-by-sensing-niche-occupancy
#7
Onur Basak, Teresa G Krieger, Mauro J Muraro, Kay Wiebrands, Daniel E Stange, Javier Frias-Aldeguer, Nicolas C Rivron, Marc van de Wetering, Johan H van Es, Alexander van Oudenaarden, Benjamin D Simons, Hans Clevers
The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate behavior of NSCs remain poorly defined. Here we propose a model in which the fate of active NSCs is coupled to the total number of neighboring NSCs in a shared niche. Using knock-in reporter alleles and single-cell RNA sequencing, we show that the Wnt target Tnfrsf19/Troy identifies both active and quiescent NSCs. Quantitative analysis of genetic lineage tracing of individual NSCs under homeostasis or in response to injury reveals rapid expansion of stem-cell number before some return to quiescence...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29294905/anxiety-and-depression-in-cyberbullied-college-students-a-retrospective-study
#8
Cristina Jenaro, Noelia Flores, Cinthia Patricia Frías
Cyberbullying is a worldwide phenomenon and its effects can be severe. To better understand the personal and situational factors in cyberbullying, we approach it from the perspective of the general aggression model. More specifically, we analyze the medium and long-term impact of past experiences of cyberbullying on university students. We also compare their psychological adjustment with peers who have not been cyberbullied by examining the recall of cyberbullying while attending secondary school of 1,593 university students...
September 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290318/-an-unusual-location-of-urethral-leiomyoma-the-most-common-pelvic-tumour-in-the-female
#9
Rubén Martínez-Castillo, Lucía Molina-Jiménez, María Jesús Pareja-Megía, Antonio Félix Conde-Martín, Antonio Robles-Frías
Urethral leiomyoma is a rare benign mesenchymal tumour arising from the smooth muscle of the urethra. It most often appears in females of reproductive age. Approximately 100 cases have been reported to date. The most usual presentation is urinary infection, hematuria or a mass. We report a case of a 42 year old woman who presented with sporadic hematuria, dysuria and dyspareunia. Histopathological studies confirmed urethral leiomyoma.
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29287906/mexican-consensus-on-lysosomal-acid-lipase-deficiency-diagnosis
#10
R Vázquez-Frias, J E García-Ortiz, P F Valencia-Mayoral, G E Castro-Narro, P G Medina-Bravo, Y Santillán-Hernández, J Flores-Calderón, R Mehta, C A Arellano-Valdés, L Carbajal-Rodríguez, J I Navarrete-Martínez, M L Urbán-Reyes, M T Valadez-Reyes, F Zárate-Mondragón, A Consuelo-Sánchez
INTRODUCTION: Lysosomal acid lipase deficiency (LAL-D) causes progressive cholesteryl ester and triglyceride accumulation in the lysosomes of hepatocytes and monocyte-macrophage system cells, resulting in a systemic disease with various manifestations that may go unnoticed. It is indispensable to recognize the deficiency, which can present in patients at any age, so that specific treatment can be given. The aim of the present review was to offer a guide for physicians in understanding the fundamental diagnostic aspects of LAL-D, to successfully aid in its identification...
December 26, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29259059/protocol-for-the-brecar-study-a-prospective-cohort-follow-up-on-the-impact-of-breast-reconstruction-timing-on-health-related-quality-of-life-in-women-with-breast-cancer
#11
Maria Herrera de la Muela, Enrique García López, Laura Frías Aldeguer, Paloma Gómez-Campelo
INTRODUCTION: The completion of postmastectomy breast reconstruction (BR) in women with breast cancer can last from months to years, and to our knowledge, there is a lack of studies that analyse how the different types and times of reconstruction impact on the patient's quality of life and psychosocial adjustment.The primary aim of the BREast Cancer Reconstruction (BRECAR Study) is twofold. First, to describe health-related quality of life (HRQoL), overall satisfaction with surgery and psychological impact (body image, self-esteem, depression and anxiety) on women who will have undergone a mastectomy with planned BR, considering the varied timing of BR procedures (immediate BR (iBR), delayed BR (dBR) and two-stage BR (2sBR))...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29245109/autosomal-recessive-hypercholesterolemia-in-spain
#12
Rosa María Sánchez-Hernández, Pablo Prieto-Matos, Fernando Civeira, Eduardo Esteve Lafuente, Manuel Frías Vargas, José T Real, Fernando Goñi Goicoechea, Francisco J Fuentes, Miguel Pocovi, Mauro Boronat, Ana María Wägner, Luis Masana
BACKGROUND AND AIMS: Autosomal recessive hypercholesterolemia (ARH) is a very rare disease, caused by mutations in LDL protein receptor adaptor 1 (LDLRAP1). It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature cardiovascular disease. We aimed to characterize ARH in Spain. METHODS: Data were collected from the Dyslipidemia Registry of the Spanish Atherosclerosis Society. A literature search was performed up to June 2017, and all diagnostic genetic studies for familial hypercholesterolemia of Spain were reviewed...
December 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29239718/new-hepatitis-c-virus-genotype-1-subtype-naturally-harbouring-resistance-associated-mutations-to-ns5a-inhibitors
#13
Laura Ordeig, Damir Garcia-Cehic, Josep Gregori, Maria Eugenia Soria, Leonardo Nieto-Aponte, Celia Perales, Meritxell Llorens, Qian Chen, Mar Riveiro-Barciela, Maria Buti, Rafael Esteban, Juan Ignacio Esteban, Francisco Rodriguez-Frias, Josep Quer
Hepatitis C virus (HCV) is a highly divergent virus currently classified into seven major genotypes and 86 subtypes (ICTV, June 2017), which can have differing responses to therapy. Accurate genotyping/subtyping using high-resolution HCV subtyping enables confident subtype identification, identifies mixed infections and allows detection of new subtypes. During routine genotyping/subtyping, one sample from an Equatorial Guinea patient could not be classified into any of the subtypes. The complete genomic sequence was compared to reference sequences by phylogenetic and sliding window analysis...
December 14, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29239555/analytical-report-of-the-2016-dengue-outbreak-in-c%C3%A3-rdoba-city-argentina
#14
Camilo Rotela, Laura Lopez, María Frías Céspedes, Gabriela Barbas, Andrés Lighezzolo, Ximena Porcasi, Mario A Lanfri, Carlos M Scavuzzo, David E Gorla
After elimination of the Aedes aegypti vector in South America in the 1960s, dengue outbreaks started to reoccur during the 1990s; strongly in Argentina since 1998. In 2016, Córdoba City had the largest dengue outbreak in its history. In this article we report this outbreak including spatio-temporal analysis of cases and vectors in the city. A total of 653 dengue cases were recorded by the laboratory-based dengue surveillance system and georeferenced by their residential addresses. Case maps were generated from the epidemiological week 1 (beginning of January) to week 19 (mid-May)...
November 6, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29238724/dna-damage-as-a-driver-for-growth-delay-chromosome-instability-syndromes-with-intrauterine-growth-retardation
#15
REVIEW
Benilde García-de Teresa, Mariana Hernández-Gómez, Sara Frías
DNA is constantly exposed to endogenous and exogenous mutagenic stimuli that are capable of producing diverse lesions. In order to protect the integrity of the genetic material, a wide array of DNA repair systems that can target each specific lesion has evolved. Despite the availability of several repair pathways, a common general program known as the DNA damage response (DDR) is stimulated to promote lesion detection, signaling, and repair in order to maintain genetic integrity. The genes that participate in these pathways are subject to mutation; a loss in their function would result in impaired DNA repair and genomic instability...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238183/gene-and-mirna-expression-profiles-in-pbmcs-from-patients-with-severe-and-mild-emphysema-and-pizz-alpha1-antitrypsin-deficiency
#16
Cristina Esquinas, Sabina Janciauskiene, Ricardo Gonzalo, Gemma Mas de Xaxars, Beata Olejnicka, Irene Belmonte, Miriam Barrecheguren, Esther Rodriguez, Alexa Nuñez, Francisco Rodriguez-Frias, Marc Miravitlles
Introduction: COPD has complex etiologies involving both genetic and environmental determinants. Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD). Nonetheless, AATD patients present a heterogeneous clinical evolution, which has not been completely explained by sociodemographic or clinical factors. Here we performed the gene expression profiling of blood cells collected from mild and severe COPD patients with PiZZ AATD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29232161/characterization-of-novel-missense-variants-of-serpina1-gene-causing-alpha-1-antitrypsin-deficiency
#17
Nerea Matamala, Beatriz Lara, Gema Gomez-Mariano, Selene Martínez, Diana Retana, Taiomara Fernandez, Ramona Angeles Silvestre, Irene Belmonte, Francisco Rodriguez-Frias, Marçal Vilar, Raquel Sáez, Igor Iturbe, Silvia Castillo, María Molina-Molina, Anna Texido, Gema Tirado-Conde, Jose Luis Lopez-Campos, Manuel Posada, Ignacio Blanco, Sabina Janciauskiene, Beatriz Martinez-Delgado
SERPINA1 gene is highly polymorphic, with more than one hundred variants described in databases. The SERPINA1 encodes alpha-1 antitrypsin (AAT) protein, and the severe deficiency of AAT is a major contributor to pulmonary emphysema and liver diseases. We report seven new variants in Spanish patients with AAT deficiency. All variants involved amino acid substitutions in different exons: PiSDonosti (S+Ser14Phe), PiTijarafe (Ile50Asn), PiSevilla (Ala58Asp), PiCadiz (Glu151Lys), PiTarragona (Phe227Cys), PiPuerto Real (Thr249Ala) and PiValencia (Lys328Glu)...
December 12, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29229476/recurrent-chylothorax-due-to-secondary-superior-vena-cava-obstruction
#18
Alicia Cerezo Lajas, Jesús Javier Martín Pinacho, Ingrid Frías Benzant, Javier de Miguel-Díez
No abstract text is available yet for this article.
December 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29229235/valproic-acid-disrupts-the-oscillatory-expression-of-core-circadian-rhythm-transcription-factors
#19
Chanel A Griggs, Scott W Malm, Rosa Jaime-Frias, Catharine L Smith
Valproic acid (VPA) is a well-established therapeutic used in treatment of seizure and mood disorders as well as migraines and a known hepatotoxicant. About 50% of VPA users experience metabolic disruptions, including weight gain, hyperlipidemia, and hyperinsulinemia, among others. Several of these metabolic abnormalities are similar to the effects of circadian rhythm disruption. In the current study, we examine the effect of VPA exposure on the expression of core circadian transcription factors that drive the circadian clock via a transcription-translation feedback loop...
December 8, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29223706/cross-over-clinical-trial-for-evaluating-the-safety-of-camel-s-milk-intake-in-patients-who-are-allergic-to-cow-s-milk-protein
#20
E M Navarrete-Rodríguez, L A Ríos-Villalobos, C R Alcocer-Arreguín, B E Del-Rio-Navarro, J M Del Rio-Chivardi, O J Saucedo-Ramírez, J J L Sienra-Monge, R V Frias
BACKGROUND: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. METHODS: Crossed clinical trial for the use of camel's milk vs...
December 6, 2017: Allergologia et Immunopathologia
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