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J Solbiati, J Frias-Lopez
The last few decades have witnessed an increasing interest in studying the human microbiome and its role in health and disease. The focus of those studies was mainly the characterization of changes in the composition of the microbial communities under different conditions. As a result of those studies, we now know that imbalance in the composition of the microbiome, also referred to as microbial dysbiosis, is directly linked to developing certain conditions. Dysbiosis of the oral microbiome is a prime example of how this imbalance leads to disease in the case of periodontal disease...
March 1, 2018: Journal of Dental Research
Adrián Lázaro-Frías, Sergio Gómez-Medina, Lucas Sánchez-Sampedro, Karl Ljungberg, Mart Ustav, Peter Liljeström, César Muñoz-Fontela, Mariano Esteban, Juan García-Arriaza
Zaire and Sudan ebolavirus species cause a severe disease in humans and non-human primates (NHPs) characterized by high mortality rate. There are no licensed therapies or vaccines against Ebola virus disease (EVD), and the recent 2013-2016 outbreak in West Africa highlighted the need of EVD-specific medical countermeasures. Here, we have generated and characterized head-to-head the immunogenicity and efficacy of five vaccine candidates against Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV) based on the highly attenuated poxvirus vector modified vaccinia virus Ankara (MVA), expressing either the virus glycoprotein (GP) or GP together with the virus protein 40 (VP40) forming virus-like particles (VLPs)...
March 7, 2018: Journal of Virology
Raquel Fuentes-Irigoyen, Ana María Martín de Rosales Cabrera, Ana Cristina Riestra, María Nieves Vila, Carmela Dávila-Pousa, José María Alonso Herreros, Carmen López-Cabezas, Carmen Cañete, María Sagrario Pernía-López, Marta Garcia-Palomo, Pedro Arriola Villalobos, Lucía Ibares-Frías, José Luís Urcelay Segura, Jacobo Ramón Yañez Martínez
There are many medicinal products that, although having shown efficacy and  safety in different ophthalmological indications, they are not authorized or  commercially available for ophthalmic administration. This implies, on one hand,  that they must be used according to legislation that regulates the availability of  medicines in special situations and, on the other hand, that they must be  prepared in the pharmacy services for ophthalmic administration, according to  quality criteria to ensure its effectiveness, stability and sterility...
March 1, 2018: Farmacia Hospitalaria
Victoria Kathryn Meader, Mallory G John, Laysa M Frias Batista, Syeda Ahsan, Katharine Moore Tibbetts
Plasmas with dense concentrations of reactive species such as hydrated electrons and hydroxyl radicals are generated from focusing intense femtosecond laser pulses into aqueous media. These radical species can reduce metal ions such as Au3+ to form metal nanoparticles (NPs). However, the formation of H₂O₂ by the recombination of hydroxyl radicals inhibits the reduction of Ag⁺ through back-oxidation. This work has explored the control of hydroxyl radical chemistry in a femtosecond laser-generated plasma through the addition of liquid ammonia...
February 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Juan Egea-Valenzuela, Begoña González Suárez, Cristian Sierra Bernal, José Francisco Juanmartiñena Fernández, Marisol Luján-Sanchís, Mileidis San Juan Acosta, Blanca Martínez Andrés, Vicente Pons Beltrán, Violeta Sastre Lozano, Cristina Carretero Ribón, Félix de Vera Almenar, Joaquín Sánchez Cuenca, Fernando Alberca de Las Parras, Cristina Rodríguez de Miguel, Julio Valle Muñoz, Ignacio Férnandez-Urién Sainz, Carolina Torres González, Pilar Borque Barrera, Enrique Pérez-Cuadrado Robles, Noelia Alonso Lázaro, Pilar Martínez García, César Prieto de Frías, Fernando Carballo Álvarez
BACKGROUND: Capsule endoscopy (CE) is the first-line investigation in cases of suspected Crohn's disease (CD) of the small bowel, but the factors associated with a higher diagnostic yield remain unclear. OBJECTIVE: Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers. PATIENTS AND METHODS: Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index...
February 27, 2018: European Journal of Gastroenterology & Hepatology
C M Jaramillo-Esparza, A Consuelo-Sánchez, C P Acosta-Rodríguez-Bueno, G Ramón-García, S W Sadowinski-Pine, M A Escobar-Sánchez, I Castorena-Villa, F Gaytán-Morales, R Vázquez-Frias
INTRODUCTION AND AIMS: Graft-versus-host disease (GVHD) is a common multisystemic complication of allogeneic hematopoietic cell transplantation. The most frequent presentations of graft-versus-host disease involve the skin, the gastrointestinal tract, and the liver. The aim of the present study was to know the frequency of gastrointestinal tract and liver GVHD and the characteristics of disease presentation in pediatric patients that underwent hematopoietic stem cell transplantation (HSCT) at a tertiary care hospital center in Mexico City...
February 24, 2018: Revista de Gastroenterología de México
Bernhard Ludvik, Juan P Frías, Francisco J Tinahones, Julio Wainstein, Honghua Jiang, Kenneth E Robertson, Luis-Emilio García-Pérez, D Bradley Woodward, Zvonko Milicevic
BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors improve glycaemic control and reduce bodyweight in patients with type 2 diabetes through different mechanisms. We assessed the safety and efficacy of the addition of the once-weekly GLP-1 receptor agonist dulaglutide to the ongoing treatment regimen in patients whose diabetes is inadequately controlled with SGLT2 inhibitors, with or without metformin. METHODS: AWARD-10 was a phase 3b, double-blind, parallel-arm, placebo-controlled, 24-week study done at 40 clinical sites in Austria, Czech Republic, Germany, Hungary, Israel, Mexico, Spain, and the USA...
February 23, 2018: Lancet Diabetes & Endocrinology
Antonio Rivero-Juarez, María A Risalde, Mario Frias, Ignacio García-Bocanegra, Pedro Lopez-Lopez, David Cano-Terriza, Angela Camacho, Saul Jimenez-Ruiz, Jose C Gomez-Villamandos, Antonio Rivero
BACKGROUND: It has been shown that wildlife can serve as natural reservoirs of hepatitis E virus (HEV). The wild boar (Sus scrofa) is probably the main natural reservoir of HEV and could therefore represent an important route of transmission in Europe, especially in regions where game meat is widely consumed. We evaluated the prevalence of HEV infection in wild boar in the south of Spain, with the aim of identifying associated risk factors. A cross-sectional study that included hunted wild boar was carried out during the 2015/2016 hunting season (October 15 to February 15) in Andalusia (southern Spain)...
February 27, 2018: BMC Veterinary Research
Cristian Guja, Juan P Frías, Aniko Somogyi, Serge Jabbour, Hui Wang, Elise Hardy, Julio Rosenstock
AIMS: To compare the efficacy and safety of adding the glucagon-like peptide-1 receptor agonist exenatide once weekly (QW) 2 mg or placebo among patients with type 2 diabetes inadequately controlled despite titrated insulin glargine (IG) ± metformin. METHODS: This multicentre, double-blind study randomized (1:1) patients with persistent hyperglycaemia after 8-week IG titration (glycated haemoglobin [HbA1c] 7.0-10.5% [53-91 mmol/mol]) to exenatide QW or placebo...
February 23, 2018: Diabetes, Obesity & Metabolism
Alfonso Alejo-Armijo, Nicolás Glibota, María P Frías, Joaquín Altarejos, Antonio Gálvez, Sofía Salido, Elena Ortega-Morente
Natural A-type procyanidins have shown very interesting biological activities, such as their proven antiadherence properties against pathogenic bacteria. In order to find the structural features responsible for their activities, we describe herein the design and synthesis of six A-type procyanidin analogues and the evaluation of their antimicrobial and antibiofilm properties against 12 resistant bacteria, both Gram positive and Gram negative, isolated from organic foods. The natural A-type procyanidin A-2, which had known antiadherence activity, was also tested as a reference compound for the comparative studies...
February 21, 2018: Journal of Agricultural and Food Chemistry
Susana I C J Palma, Ana P Traguedo, Ana R Porteira, Maria J Frias, Hugo Gamboa, Ana C A Roque
Non-invasive and fast diagnostic tools based on volatolomics hold great promise in the control of infectious diseases. However, the tools to identify microbial volatile organic compounds (VOCs) discriminating between human pathogens are still missing. Artificial intelligence is increasingly recognised as an essential tool in health sciences. Machine learning algorithms based in support vector machines and features selection tools were here applied to find sets of microbial VOCs with pathogen-discrimination power...
February 20, 2018: Scientific Reports
Rosario Casillas, David Tabernero, Josep Gregori, Irene Belmonte, Maria Francesca Cortese, Carolina González, Mar Riveiro-Barciela, Rosa Maria López, Josep Quer, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías
AIM: To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. METHODS: Serum samples from 246 individuals were included and divided into 3 groups: patients with chronic HBV infection (CHB) ( n = 41, 73% Caucasians), patients with resolved HBV infection ( n = 100, 100% Caucasians) and an HBV-uninfected control group ( n = 105, 100% Caucasians)...
February 14, 2018: World Journal of Gastroenterology: WJG
Lays Janaina Prazeres Marques, Dayane da Rocha Pimentel, Conceição Maria de Oliveira, Mirella Bezerra Rodrigues Vilela, Paulo Germano Frias, Cristine Vieira do Bonfim
OBJECTIVE: to assess the agreement and describe the causes and preventability of infant deaths before and after the investigation. METHODS: investigation files and death certificates of infants under one year, of mothers living in Recife, Brazil, in 2014 were used; the Cohen kappa index was adopted for agreement analysis of the underlying causes of death; the list of preventable causes of deaths by interventions of the Brazilian National Health System was also adopted...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Ronnie Aronson, Juan Frias, Allison Goldman, Amanda Darekar, Brett Lauring, Steven G Terra
AIM: This phase III, multicenter, randomised study evaluated the efficacy and safety of ertugliflozin monotherapy in adults with inadequately controlled type 2 diabetes (glycated haemoglobin [HbA1c] 7.0% to 10.5% [53-91 mmol/mol]) despite diet and exercise. MATERIALS AND METHODS: The 52-week study comprised a 26-week, double-blind, placebo-controlled period (phase A) where 461 participants received placebo, ertugliflozin 5-mg/day, or ertugliflozin 15-mg/day. This was followed by a 26-week active-controlled period (phase B) where participants in the placebo group who had not received glycaemic rescue therapy had blinded metformin added...
February 8, 2018: Diabetes, Obesity & Metabolism
Maxim Dragoun, Thomas Günther, Corazon Frias, Albrecht Berkessel, Aram Prokop
PURPOSE: We report on our preclinical findings of a simple salicylic diamine compound (THG 1213) which has yielded exceptional results as a potential chemotherapeutic drug. THG 1213 is an easy to synthesize chiral and metal-free salan compound. METHODS: THG 1213 was tested on several leukemia, lymphoma and solid tumor cell lines in vitro. The effects have been studied by LDH release essay, FACS flow cytometry, photometric cell count, immunoblotting, and NMR spectroscopy...
January 27, 2018: Journal of Cancer Research and Clinical Oncology
Pablo Toledo Frías, María Rosa Fernández Olmo, Mónica Recio Vázquez, Miren Morillas Bueno, Ana Peinado Esteban, Manuel Abeytua Jiménez
No abstract text is available yet for this article.
January 16, 2018: Revista Española de Cardiología
Sebastián Marciano, Leila Haddad, María Virginia Reggiardo, Mirta Peralta, Cecilia Vistarini, Mónica Marino, Valeria Inés Descalzi, Claudia D'Amico, Sebastián Figueroa Escuti, Luis Alejandro Gaite, Roberto Pérez Ravier, Cristina Longo, Silvia Mabel Borzi, Omar Andrés Galdame, Fernando Bessone, Hugo Alberto Fainboim, Silvia Frías, Mariano Cartier, Adrián Carlos Gadano
We report the first real-world prospective multicenter cohort study that evaluated the effectiveness and safety of original or generic sofosbuvir-based regimens in patients with chronic hepatitis C in Latin America. The main endpoints were assessment of sustained virological response and serious adverse events rates. A total of 321 patients with chronic hepatitis C treated with the following regimens were included: sofosbuvir plus daclatasvir for 12 (n = 34) or 24 (n = 135) weeks, sofosbuvir plus daclatasvir plus ribavirin for 12 (n = 84) or 24 (n = 56) weeks, or sofosbuvir plus ribavirin for 12 (n = 8) or 24 (n = 2) weeks...
January 19, 2018: Journal of Medical Virology
Alec J Hirsch, Victoria H J Roberts, Peta L Grigsby, Nicole Haese, Matthias C Schabel, Xiaojie Wang, Jamie O Lo, Zheng Liu, Christopher D Kroenke, Jessica L Smith, Meredith Kelleher, Rebecca Broeckel, Craig N Kreklywich, Christopher J Parkins, Michael Denton, Patricia Smith, Victor DeFilippis, William Messer, Jay A Nelson, Jon D Hennebold, Marjorie Grafe, Lois Colgin, Anne Lewis, Rebecca Ducore, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Ashlee V Moses, Terry K Morgan, Antonio E Frias, Daniel N Streblow
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi...
January 17, 2018: Nature Communications
Isabel Pont, Aracely Calatayud-Pascual, Alicia López-Castellano, Elena P Albelda, Enrique García-España, Luis Martí-Bonmatí, Juan C Frias, M Teresa Albelda
Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.
2018: PloS One
Abril K Romo-Piñera, Ofelia Escobar-Sánchez, Jorge Ruelas-Inzunza, Martín G Frías-Espericueta
We evaluated the total Hg concentration in different tissues of squalid callista Megapitaria squalida in order to measure Hg distribution in tissue and to estimate human health risk. Samples were obtained by free diving in the SW Gulf of California, Mexico. Concentrations are given on a wet weight basis. A total of 89 squalid callista specimens were obtained, presenting an average Hg concentration of 0.07 ± 0.04 µg g-1. There were no significant differences (p > 0.05) in Hg concentration between tissues (visceral mass = 0...
January 15, 2018: Bulletin of Environmental Contamination and Toxicology
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