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Fabián E Olazaran, Gildardo Rivera, Alondra M Pérez-Vázquez, Cynthia M Morales-Reyes, Aldo Segura-Cabrera, Isaías Balderas-Rentería
Potential anticancer activity of 16 azetidin-2-one derivatives was evaluated showing that compound 6 [N-(p-methoxy-phenyl)-2-(p-methyl-phenyl)-3-phenoxy-azetidin-2-one] presented cytotoxic activity in SiHa cells and B16F10 cells. The caspase-3 assay in B16F10 cells displayed that azetidin-2-one derivatives induce apoptosis. Microarray and molecular analysis showed that compound 6 was involved on specific gene overexpression of cytoskeleton regulation and apoptosis due to the inhibition of some cell cycle genes...
January 12, 2017: ACS Medicinal Chemistry Letters
J Rolando Bastida-Zavala, Alondra Sofía Rodríguez Buelna, Jesús Angel DE León-González, Karla Andrea Camacho-Cruz, Isabel Carmona
Sabellids and serpulids are two well represented families in the polychaete fauna of the Tropical Eastern Pacific, with 31 and 34 species respectively; however, most records come from the Gulf of California or the western coast of Baja California Peninsula. Only a few records are from localities in the large expanse of the central and southern Mexican Pacific. Thus, sabellids and serpulids were collected from several shallow water habitats along the coast of Mexican Pacific, such as coastal lagoons, coral reefs, rocky shores and from man-made structures as marinas, piers and ships of several harbors; additionally, specimens from national collections were revised...
November 7, 2016: Zootaxa
Alondra Escudero-Castellanos, Blanca E Ocampo-García, Ma Victoria Domínguez-García, Jaime Flores-Estrada, Miriam V Flores-Merino
Hydrogels are suitable materials to promote cell proliferation and tissue support because of their hydrophilic nature, porous structure and sticky properties. However, hydrogel synthesis involves the addition of additives that can increase the risk of inducing cytotoxicity. Sterilization is a critical process for hydrogel clinical use as a proper scaffold for tissue engineering. In this study, poly(ethylene glycol) (PEG), poly(ethylene glycol)-chitosan (PEG-CH) and multi-arm PEG hydrogels were synthesized by free radical polymerization and sterilized by gamma irradiation or disinfected using 70 % ethanol...
December 2016: Journal of Materials Science. Materials in Medicine
Alondra Frías, Alex Ortiz, Miriam Soto, Francisco Muñoz, Carolina Chacón
We report a 41-year-old man with HIV and a chronic obstructive pulmonary disease, treated for seven months with Fluticasone/Salmeterol and antiretroviral therapy (Lamivudine, Tenofovir, Atazanavir and Ritonavir). While using these medications, the patients developed a Cushing syndrome in a period of five months. After performing laboratory and imaging tests, it was concluded that the most probable cause of the syndrome was the interaction of inhaled steroids with Ritonavir. After discontinuing these medications the syndrome reverted in a period of 8 months...
July 2016: Revista Médica de Chile
Alondra Nelson
No abstract text is available yet for this article.
October 2016: American Journal of Public Health
Alondra Nelson
Black Lives Matter was first articulated just a few years ago, but it has been the leitmotif of antiracist struggles for generations. The Movement for Black Lives extends the work of previous movements that challenged forms of oppression that act on Black bodies with impunity. It should be understood in the context of Ida B. Wells' anti-lynching campaign, Fannie Lou Hamer's reproductive justice demands, and the Black Panther Party's health activism. The 50th anniversary of the Black Panther Party is an occasion to recall that its work confronted the callous neglect and the corporeal surveillance and abuse of poor Black communities...
October 2016: American Journal of Public Health
Rosa Elena Arroyo-Carmona, Ana Laura López-Serrano, Alondra Albarado-Ibañez, Francisca María Fabiola Mendoza-Lucero, David Medel-Cajica, Ruth Mery López-Mayorga, Julián Torres-Jácome
According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which are commonly used, do not suggest the diabetes progress in the patient. In this study, the streptozotocin model in mice (cDM) was used as early diagnostic criterion to reduce the side effects related to the illness...
2016: Journal of Diabetes Research
Namyr A Martinez, Alondra M Ayala, Magdiel Martinez, Freddyson J Martinez-Rivera, Jorge D Miranda, Walter I Silva
Damage to the CNS can cause a differential spatio-temporal release of multiple factors, such as nucleotides, ATP and UTP. The latter interact with neuronal and glial nucleotide receptors. The P2Y2 nucleotide receptor (P2Y2R) has gained prominence as a modulator of gliotic responses after CNS injury. Still, the molecular mechanisms underlying these responses in glia are not fully understood. Membrane-raft microdomains, such as caveolae, and their constituent caveolins, modulate receptor signaling in astrocytes; yet, their role in P2Y2R signaling has not been adequately explored...
June 3, 2016: Journal of Biological Chemistry
Alondra Schweizer Burguete, Sandra Almeida, Fen-Biao Gao, Robert Kalb, Michael R Akins, Nancy M Bonini
Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neuritic granules that undergo active transport into distal neuritic segments. In cultured mammalian spinal cord neurons, the presence of neuritic GGGGCC repeat RNA correlates with neuronal branching defects, and the repeat RNA localizes to granules that label with fragile X mental retardation protein (FMRP), a transport granule component...
December 9, 2015: ELife
Alondra M Idrovo Encalada, Maria F Basanta, Eliana N Fissore, Maria D De'Nobili, Ana M Rojas
The effect of particle size (53, 105 and 210 μm) of carrot fiber (CF) on their hydration properties and antioxidant capacity as well as on the performance of the CF-composite films developed with commercial low methoxyl pectin (LMP) was studied. It was determined that CF contained carotenoids and phenolics co-extracted with polysaccharides (80%), rich in pectins (15%). CF showed antioxidant activity and produced homogeneous calcium-LMP-based composites. The 53-μm-CF showed the lowest hydration capability and produced the least elastic and deformable composite film due probably to CF bridged by calcium-crosslinked LMP chains...
January 20, 2016: Carbohydrate Polymers
Juan G Sierra-Madero, Susan S Ellenberg, Mohammed S Rassool, Ann Tierney, Pablo F Belaunzarán-Zamudio, Alondra López-Martínez, Alicia Piñeirúa-Menéndez, Luis J Montaner, Livio Azzoni, César Rivera Benítez, Irini Sereti, Jaime Andrade-Villanueva, Juan L Mosqueda-Gómez, Benigno Rodriguez, Ian Sanne, Michael M Lederman
BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is a common complication of antiretroviral therapy (ART) in patients with HIV. IRIS is associated with an increased risk of admission to hospital and death. We assessed whether CCR5 blockade with maraviroc reduces the risk of IRIS. METHODS: The CADIRIS study was a double-blind, randomised, placebo-controlled trial that recruited participants from five clinical sites in Mexico and one in South Africa and followed them for 1 year...
November 2014: Lancet HIV
Juan G Sierra-Madero, Susan Ellenberg, Mohammed S Rassool, Ann Tierney, Pablo F Belaunzarán-Zamudio, Alondra López-Martínez, Alicia Piñeirúa-Menéndez, Luis J Montaner, Livio Azzoni, César Rivera Benítez, Irini Sereti, Jaime Andrade-Villanueva, Juan L Mosqueda-Gómez, Benigno Rodriguez, Ian Sanne, Michael M Lederman
BACKGROUND: Immune Reconstitution Inflammatory Syndrome (IRIS) is a common complication of antiretroviral therapy (ART) in HIV-infected patients. IRIS is associated with an increased risk of hospitalization and death. We ascertained whether CCR5 blockade using maraviroc reduces the risk of IRIS. METHODS: The CADIRIS study was a randomized, double-blind, placebo-controlled, clinical trial that accrued subjects from five clinical sites in Mexico and one in South Africa between November 2009 and January 2012, and followed them for one year...
November 1, 2014: Lancet HIV
Fernando Guardado-Bermúdez, Araceli Aguilar-Jaimes, Fernando Josafat Ardisson-Zamora, Luis Alberto Guerrero-Silva, Estefanie Villanueva-Rodríguez, Nubia Alondra Gómez-de Leija
BACKGROUND: Spontaneous cholecystocutaneous fistula is defined as a gallbladder communication with the external environment through the abdominal wall rupture; the first reports were written in the seventeenth century by Thilesus. During the past 50 years 25 cases have been reported. CLINICAL CASE: We report a case of a 30-year-old woman presented with a five-year history of biliary colic, six months prior to medical assessment presents outlet of biliary material and gallstones spontaneously in the right upper quadrant...
January 2015: Cirugia y Cirujanos
Federica Messina, Massimo Curini, Chiara Di Sano, Claudia Zadra, Giulia Gigliarelli, Luisa Alondra Rascón-Valenzuela, Ramón Enrique Robles Zepeda, Maria Carla Marcotullio
A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The antiproliferative activity of the major compounds was evaluated in different murine cancer cell lines (M12.C3.F6 and RAW264.7) and human cancer cells (A549, HeLa, and PC-3). The new compounds (1-3) did not show significant antiproliferative activity...
May 22, 2015: Journal of Natural Products
Luisa Alondra Rascón Valenzuela, Manuel Jiménez Estrada, Carlos Arturo Velázquez Contreras, Adriana Garibay Escobar, Luis Angel Medina Juárez, Nohemi Gámez Meza, Ramón Enrique Robles Zepeda
CONTEXT: Asclepias subulata Decne. (Apocynaceae) is a shrub used in the Mexican traditional medicine for the treatment of cancer. OBJECTIVE: The objective of this study was to evaluate the antiproliferative activity of methanol extract of aerial parts of A. subulata and its fractions against different cancer cell lines. Additionally, we analyzed the mechanism of action of the active fractions. MATERIALS AND METHODS: Methanol extract fractions were prepared by serial extraction with n-hexane, ethyl acetate, and ethanol...
2015: Pharmaceutical Biology
Esther A Torres, Namyr A Martínez, Patricia Martínez, Alondra M Ayala, Daniel Millián, Celia Rivera, Marien Saadé, Jean Davis
OBJECTIVE: To describe the profile of the average organ non-donor, compare it to that of the average donor, and identify characteristics that predict the likelihood that a given individual will be a non-donor. METHODS: The charts of 397 consenting potential organ donors of LifeLink of Puerto Rico from 2009 through 2011 were reviewed. Data regarding gender, age, BMI, the presence of diabetes, hypertension and/or kidney injury, death from cerebrovascular accident, and smoking were collected...
September 2014: Puerto Rico Health Sciences Journal
Fernando Guardado-Bermúdez, Armando Javier Azuara-Turrubiates, Fernando Josafat Ardisson-Zamora, Luis Alberto Guerrero-Silva, Estefanie Villanueva-Rodríguez, Nubia Alondra Gómez-de Leija
BACKGROUND: The most frequent etiology of pancreatic pseudocyst is acute pancreatitis and exacerbations of chronic pancreatitis, presenting spontaneous resolution in 50% of the cases. Treatment is indicated in symptomatic or complicated persistent pseudocysts. The OBJECTIVE of this article is to present a case and management options of pancreatic pseudocyst defined as a collection of fluid in the omental bursa. CLINICAL CASE: We present the case of a 59-year-old female patient with a history of laparoscopic cholecystectomy and necrotizing pancreatitis...
July 2014: Cirugia y Cirujanos
Alondra Torres Trueba, Maaike C Kroon, Cor J Peters, Igor L Moudrakovski, Christopher I Ratcliffe, Saman Alavi, John A Ripmeester
Prospective industrial applications of clathrate hydrates as materials for gas separation require further knowledge of cavity distortion, cavity selectivity, and defects induction by guest-host interactions. The results presented in this contribution show that under certain temperature conditions the guest combination of CH3F and a large polar molecule induces defects on the clathrate hydrate framework that allow intercage guest dynamics. (13)C NMR chemical shifts of a CH3F/CH4/TBME sH hydrate and a temperature analysis of the (2)H NMR powder lineshapes of a CD3F/THF sII and CD3F/TBME sH hydrate, displayed evidence that the populations of CH4 and CH3F in the D and D' cages were in a state of rapid exchange...
June 7, 2014: Journal of Chemical Physics
Cristina Torres-Machí, Alondra Chamorro, Carlos Videla, Eugenio Pellicer, Víctor Yepes
Pavement maintenance is one of the major issues of public agencies. Insufficient investment or inefficient maintenance strategies lead to high economic expenses in the long term. Under budgetary restrictions, the optimal allocation of resources becomes a crucial aspect. Two traditional approaches (sequential and holistic) and four classes of optimization methods (selection based on ranking, mathematical optimization, near optimization, and other methods) have been applied to solve this problem. They vary in the number of alternatives considered and how the selection process is performed...
2014: TheScientificWorldJournal
Alondra M Díaz-Lameiro, Taras K Oleksyk, Fernando J Bird-Picó, Juan Carlos Martínez-Cruzado
Little is known about the natural history of the Sphaerodactylus species endemic to the three islands located in the Mona Passage separating the Greater Antillean islands of Hispaniola and Puerto Rico. In this study, parts of two mitochondrial genes, 16S rRNA and 12S rRNA, were sequenced to determine the relationships between the sphaerodactylids that live in the Mona Passage and other Caribbean species from the same genus. While the main goal was to identify the biogeographical origin of these species, we also identified a genetically distinct type of dwarf gecko that warrants future evaluation as a possible new species...
November 2013: Ecology and Evolution
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