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Cortney A Franklin, Alondra D Garza
The aftermath of sexual assault warrants further attention surrounding the responses provided by those to whom survivors disclose, especially when perpetrator type or victim race may affect whether the bystander response is supportive or attributes culpability to the victim. Disclosure responses have significant consequences for survivors' posttrauma mental health and formal help-seeking behavior. The current study used a sample of 348 self-report, paper-and-pencil surveys administered during the fall 2015 semester to a purposive sample of undergraduate students with a mean age of 20...
March 1, 2018: Journal of Interpersonal Violence
Ana Alondra Sobrevilla-Navarro, Ana Sandoval-Rodríguez, Jesús Javier García-Bañuelos, Juan Armendariz-Borunda, Adriana María Salazar-Montes
Adenoviruses are the most common vectors used in clinical trials of gene therapy. In 2017, 21.2% of clinical trials used rAds as vectors. Systemic administration of rAds results in high tropism in the liver. Interferon types α and β are the major antiviral cytokines which orchestrate the host's immune response against rAd, limiting therapeutic gene expression and preventing subsequent vector administration. siRNA is small double-strand RNAs that temporally inhibit the expression of a specific gene. The aim is to evaluate the effect of IFN-α blocking by a specific siRNA on Ad-GFP transduction and on transgene expression in Huh7 cells in culture...
February 24, 2018: Molecular Biotechnology
Alondra P Harris, Kareem A Ismail, Martha Nunez, Ira Martopullo, Alejandro Lencinas, Ornella I Selmin, Raymond B Runyan
Exposure to trichloroethylene (TCE) is linked to formation of congenital heart defects in humans and animals. Prior interactome analysis identified the transcription factor, Hepatocyte Nuclear Factor 4 alpha (HNF4a), as a potential target of TCE exposure. As a role for HNF4a is unknown in the heart, we examined developing avian hearts for HNF4a expression and for sensitivity to TCE and the HNF4a agonist, Benfluorex. In vitro analysis using a HNF4a reporter construct showed both TCE and HFN4a to be antagonists of HNF4a-mediated transcription at the concentrations tested...
January 3, 2018: Toxicology Letters
Stephanie A Valenzuela, Alondra J Cortés, Zakery J E Tippins, Morgan H Daly, Terell E Keel, Benjamin F Gherman, John D Spence
A combined computational and experimental study was conducted to examine the effect of extended benzannelation orientation on C(1)-C(5) and C(1)-C(6) cyclization of acyclic quinoxalenediynes. Calculations (mPW1PW91/cc-pVTZ//mPW1PW91/6-31G(d,p)) on terminal and phenylethynyl-substituted 5,6-diethynylquinoxaline and 6,7-diethynylquinoxaline showed C(1)-C(6) Bergman cyclization as the favored thermodynamic reaction pathway, with larger C(1)-C(6) preference for the angular quinoxalenediynes due to gain of a new aromatic sextet...
November 21, 2017: Journal of Organic Chemistry
Irma Palma Manríquez, Claudia Moreno Standen, Andrea Álvarez Carimoney, Alondra Richards
OBJECTIVES: To explore the ways in which medical abortion pills are obtained and used by university students in Chile in a clandestine context. STUDY DESIGN: Using a qualitative approach, we conducted in-depth interviews with 30 young women who had had a medical abortion between 2006 and 2016 while attending university. We recorded the details of their pathways to abortion and their experience of abortion, and how they used networks in the university to find the pills and learn how to use them...
February 2018: Contraception
Giulia Gigliarelli, Claudia Zadra, Lina Cossignani, Ramon Enrique Robles Zepeda, Luisa Alondra Rascón-Valenzuela, Carlos Arturo Velázquez-Contreras, Maria Carla Marcotullio
Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells...
September 18, 2017: Natural Product Research
Deborah Jacobs-Sera, Oana Catinas, Mariceli Fernandez-Martinez, Amelia Garcia, Rebecca A Garlena, Carlos A Guerrero Bustamante, Michelle H Larsen, Rosa H Medellin, Martin Y Melendez-Ortiz, Crystal M Melendez-Rivera, Alondra K Mercado-Andino, Abner J Mercado-Delgado, Cathia P Ortiz-Ortiz, Ana M Quesada-Gordillo, Jacqueline M Ramos, Michael R Rubin, Daniel A Russell, Rachna A Sadana, Sanghamitra Saha, Edwin Vazquez, David Villarreal, Graham F Hatfull
We describe the genome sequences of three closely related mycobacteriophages, Kerberos, Pomar16, and StarStuff, isolated at similar times but from geographically distinct regions. All three genomes are similar to those of other subcluster A2 phages, such as L5 and D29, are temperate, and have siphoviral virion morphologies.
August 10, 2017: Genome Announcements
David García-Gudiño, Emmanuel Landa, Joel Mendoza-Temis, Alondra Albarado-Ibañez, Juan C Toledo-Roy, Irving O Morales, Alejandro Frank
When a complex dynamical system is externally disturbed, the statistical moments of signals associated to it can be affected in ways that depend on the nature and amplitude of the perturbation. In systems that exhibit phase transitions, the statistical moments can be used as Early Warnings (EW) of the transition. A natural question is thus to wonder what effect external disturbances have on the EWs of system. In this work we study the impact of external noise added to the system on the EWs, with particular focus on understanding the importance of the amplitude and complexity of the noise...
2017: PloS One
Diane C Mitchell, Javier Castro, Tracey L Armitage, Alondra J Vega-Arroyo, Sally C Moyce, Daniel J Tancredi, Deborah H Bennett, James H Jones, Tord Kjellstrom, Marc B Schenker
OBJECTIVE: The California heat illness prevention study (CHIPS) devised methodology and collected physiological data to assess heat related illness (HRI) risk in Latino farmworkers. METHODS: Bilingual researchers monitored HRI across a workshift, recording core temperature, work rate (metabolic equivalents [METs]), and heart rate at minute intervals. Hydration status was assessed by changes in weight and blood osmolality. Personal data loggers and a weather station measured exposure to heat...
July 2017: Journal of Occupational and Environmental Medicine
Matthew Zook, Solon Barocas, Danah Boyd, Kate Crawford, Emily Keller, Seeta Peña Gangadharan, Alyssa Goodman, Rachelle Hollander, Barbara A Koenig, Jacob Metcalf, Arvind Narayanan, Alondra Nelson, Frank Pasquale
No abstract text is available yet for this article.
March 2017: PLoS Computational Biology
Fabián E Olazaran, Gildardo Rivera, Alondra M Pérez-Vázquez, Cynthia M Morales-Reyes, Aldo Segura-Cabrera, Isaías Balderas-Rentería
Potential anticancer activity of 16 azetidin-2-one derivatives was evaluated showing that compound 6 [N-(p-methoxy-phenyl)-2-(p-methyl-phenyl)-3-phenoxy-azetidin-2-one] presented cytotoxic activity in SiHa cells and B16F10 cells. The caspase-3 assay in B16F10 cells displayed that azetidin-2-one derivatives induce apoptosis. Microarray and molecular analysis showed that compound 6 was involved on specific gene overexpression of cytoskeleton regulation and apoptosis due to the inhibition of some cell cycle genes...
January 12, 2017: ACS Medicinal Chemistry Letters
J Rolando Bastida-Zavala, Alondra Sofía Rodríguez Buelna, Jesús Angel DE León-González, Karla Andrea Camacho-Cruz, Isabel Carmona
Sabellids and serpulids are two well represented families in the polychaete fauna of the Tropical Eastern Pacific, with 31 and 34 species respectively; however, most records come from the Gulf of California or the western coast of Baja California Peninsula. Only a few records are from localities in the large expanse of the central and southern Mexican Pacific. Thus, sabellids and serpulids were collected from several shallow water habitats along the coast of Mexican Pacific, such as coastal lagoons, coral reefs, rocky shores and from man-made structures as marinas, piers and ships of several harbors; additionally, specimens from national collections were revised...
November 7, 2016: Zootaxa
Alondra Escudero-Castellanos, Blanca E Ocampo-García, Ma Victoria Domínguez-García, Jaime Flores-Estrada, Miriam V Flores-Merino
Hydrogels are suitable materials to promote cell proliferation and tissue support because of their hydrophilic nature, porous structure and sticky properties. However, hydrogel synthesis involves the addition of additives that can increase the risk of inducing cytotoxicity. Sterilization is a critical process for hydrogel clinical use as a proper scaffold for tissue engineering. In this study, poly(ethylene glycol) (PEG), poly(ethylene glycol)-chitosan (PEG-CH) and multi-arm PEG hydrogels were synthesized by free radical polymerization and sterilized by gamma irradiation or disinfected using 70 % ethanol...
December 2016: Journal of Materials Science. Materials in Medicine
Alondra Frías, Alex Ortiz, Miriam Soto, Francisco Muñoz, Carolina Chacón
We report a 41-year-old man with HIV and a chronic obstructive pulmonary disease, treated for seven months with Fluticasone/Salmeterol and antiretroviral therapy (Lamivudine, Tenofovir, Atazanavir and Ritonavir). While using these medications, the patients developed a Cushing syndrome in a period of five months. After performing laboratory and imaging tests, it was concluded that the most probable cause of the syndrome was the interaction of inhaled steroids with Ritonavir. After discontinuing these medications the syndrome reverted in a period of 8 months...
July 2016: Revista Médica de Chile
Alondra Nelson
No abstract text is available yet for this article.
October 2016: American Journal of Public Health
Alondra Nelson
Black Lives Matter was first articulated just a few years ago, but it has been the leitmotif of antiracist struggles for generations. The Movement for Black Lives extends the work of previous movements that challenged forms of oppression that act on Black bodies with impunity. It should be understood in the context of Ida B. Wells' anti-lynching campaign, Fannie Lou Hamer's reproductive justice demands, and the Black Panther Party's health activism. The 50th anniversary of the Black Panther Party is an occasion to recall that its work confronted the callous neglect and the corporeal surveillance and abuse of poor Black communities...
October 2016: American Journal of Public Health
Rosa Elena Arroyo-Carmona, Ana Laura López-Serrano, Alondra Albarado-Ibañez, Francisca María Fabiola Mendoza-Lucero, David Medel-Cajica, Ruth Mery López-Mayorga, Julián Torres-Jácome
According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which are commonly used, do not suggest the diabetes progress in the patient. In this study, the streptozotocin model in mice (cDM) was used as early diagnostic criterion to reduce the side effects related to the illness...
2016: Journal of Diabetes Research
Namyr A Martinez, Alondra M Ayala, Magdiel Martinez, Freddyson J Martinez-Rivera, Jorge D Miranda, Walter I Silva
Damage to the CNS can cause a differential spatio-temporal release of multiple factors, such as nucleotides, ATP and UTP. The latter interact with neuronal and glial nucleotide receptors. The P2Y2 nucleotide receptor (P2Y2R) has gained prominence as a modulator of gliotic responses after CNS injury. Still, the molecular mechanisms underlying these responses in glia are not fully understood. Membrane-raft microdomains, such as caveolae, and their constituent caveolins, modulate receptor signaling in astrocytes; yet, their role in P2Y2R signaling has not been adequately explored...
June 3, 2016: Journal of Biological Chemistry
Alondra Schweizer Burguete, Sandra Almeida, Fen-Biao Gao, Robert Kalb, Michael R Akins, Nancy M Bonini
Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neuritic granules that undergo active transport into distal neuritic segments. In cultured mammalian spinal cord neurons, the presence of neuritic GGGGCC repeat RNA correlates with neuronal branching defects, and the repeat RNA localizes to granules that label with fragile X mental retardation protein (FMRP), a transport granule component...
December 9, 2015: ELife
Alondra M Idrovo Encalada, Maria F Basanta, Eliana N Fissore, Maria D De'Nobili, Ana M Rojas
The effect of particle size (53, 105 and 210 μm) of carrot fiber (CF) on their hydration properties and antioxidant capacity as well as on the performance of the CF-composite films developed with commercial low methoxyl pectin (LMP) was studied. It was determined that CF contained carotenoids and phenolics co-extracted with polysaccharides (80%), rich in pectins (15%). CF showed antioxidant activity and produced homogeneous calcium-LMP-based composites. The 53-μm-CF showed the lowest hydration capability and produced the least elastic and deformable composite film due probably to CF bridged by calcium-crosslinked LMP chains...
January 20, 2016: Carbohydrate Polymers
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