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JOURNAL ARTICLE
Mario Enrique Alcocer-Ávila, Alexandre Larouze, Jean-Emmanuel Groetz, Elif Hindié, Christophe Champion
BACKGROUND: Monte Carlo simulations have been considered for a long time the gold standard for dose calculations in conventional radiotherapy and are currently being applied for the same purpose in innovative radiotherapy techniques such as targeted radionuclide therapy (TRT). PURPOSE: We present in this work a benchmarking study of the latest version of the Transport d'Ions Lourds Dans l'Aqua & Vivo (TILDA-V ) Monte Carlo track structure code, highlighting its capabilities for describing the full slowing down of <mml:math xmlns:mml="https://www...
March 13, 2024: Medical Physics
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JOURNAL ARTICLE
Vittorio Picchio, Roberto Gaetani, Francesca Pagano, Yuriy Derevyanchuk, Olivia Pagliarosi, Erica Floris, Claudia Cozzolino, Giacomo Bernava, Antonella Bordin, Filipe Rocha, Ana Rita Simões Pereira, Augusto Ministro, Ana Teresa Pinto, Elena De Falco, Gianpaolo Serino, Diana Massai, Radia Tamarat, Maurizio Pesce, Susana Constantino Rosa Santos, Elisa Messina, Isotta Chimenti
Radiotherapy-induced cardiac toxicity and consequent diseases still represent potential severe late complications for many cancer survivors who undergo therapeutic thoracic irradiation. We aimed to assess the phenotypic and paracrine features of resident cardiac mesenchymal stromal cells (CMSCs) at early follow-up after the end of thoracic irradiation of the heart as an early sign and/or mechanism of cardiac toxicity anticipating late organ dysfunction. Resident CMSCs were isolated from a rat model of fractionated thoracic irradiation with accurate and clinically relevant heart dosimetry that developed delayed dose-dependent cardiac dysfunction after 1 year...
March 1, 2024: International Journal of Molecular Sciences
#23
JOURNAL ARTICLE
Fumiyasu Matsubayashi, Taro Takahashi, Hikaru Miyauchi, Yasushi Ito, Arisa Harada, Yasuo Yoshioka
The purpose of this study was to evaluate the dose attenuation of Motiva Flora® (Flora, Establishment Labs, Alajuela, Costa Rica) tissue expander with a radiofrequency identification port locator and to develop a model for accurate postmastectomy radiation therapy planning. Dose attenuation was measured using an EBT3 film (Ashland, Bridgewater, NJ), and the optimal material and density assignment for the radiofrequency identification coil for dose calculation were investigated using the AcurosXB algorithm on the Eclipse (Varian Medical Systems, Palo Alto, CA) treatment planning system...
March 8, 2024: Journal of Radiation Research
#24
JOURNAL ARTICLE
Per Gerde, Carl-Olof Sjöberg, Helen Bäckroos, Joakim Englund, Marit Wangheim, Helena Litorp
BACKGROUND: In development of inhaled drugs- and formulations the measured concentration in the systemic circulation is often used as a surrogate for local dosimetry in the lungs. To further elucidate regional differences in the fate of drugs in the lungs, different aerodynamic sizes of aerosols have been used to target major airway regions. An alternative approach to achieve regional targeting of aerosols, is to use a defined aerosol bolus together with a bolus breath hold strategy. A small volume of test aerosol is intercalated and stopped at different penetration depths, to achieve increased drug deposition at chosen lung locations...
March 7, 2024: European Journal of Pharmaceutical Sciences
#25
JOURNAL ARTICLE
Adriaan L Frencken, Devon Richtsmeier, R Lee Leonard, Aleia G Williams, Charles E Johnson, Jacqueline A Johnson, Barbara Blasiak, Andrzej Orlef, Agnieszka Skorupa, Maria Sokół, Boguslaw Tomanek, Wayne Beckham, Magdalena Bazalova-Carter, Frank C J M van Veggel
Ionizing radiation has become widely used in medicine, with application in diagnostic techniques, such as computed tomography (CT) and radiation therapy (RT), where X-rays are used to diagnose and treat tumors. The X-rays used in CT and, in particular, in RT can have harmful side effects; hence, an accurate determination of the delivered radiation dose is of utmost importance to minimize any damage to healthy tissues. For this, medical specialists mostly rely on theoretical predictions of the delivered dose or external measurements of the dose...
March 6, 2024: ACS Applied Materials & Interfaces
#26
JOURNAL ARTICLE
Tetsuro Tago, Muneyuki Sakata, Masakatsu Kanazawa, Shigeyuki Yamamoto, Kenji Ishii, Jun Toyohara
PURPOSE: Histone deacetylase 6 (HDAC6) has emerged as a therapeutic target for neurodegenerative diseases such as Alzheimer's disease. Noninvasive imaging of HDAC6 in the brain by positron emission tomography (PET) would accelerate research into its roles in these diseases. We recently discovered an 18 F-labeled derivative of the selective HDAC6 inhibitor SW-100 ([18 F]FSW-100) as a potential candidate for brain HDAC6 radioligand. As a mandatory step prior to clinical translation, we performed preclinical validation of [18 F]FSW-100...
March 5, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#27
JOURNAL ARTICLE
Oksana Cherednichenko, Anastassiya Pilyugina, Serikbai Nuraliev, Dinara Azizbekova
The dosimetry and control of exposure for individuals chronically exposed to ionizing radiation are important and complex issues. Assessment may be optimized by evaluating individual adaptation and radiosensitivity, but it is not possible for a single model to account for all relevant parameters. Our goal was to develop approaches for the calculation of doses for persons chronically exposed to ionizing radiation, taking their radiosensitivities into consideration. On the basis of ex vivo radiation of blood samples, dose-effect models were constructed for dose ranges 0...
2024: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
#28
JOURNAL ARTICLE
Matthew James Large, Aishah Bashiri, Yashiv Dookie, Joanne McNamara, Luca Antognini, Saba Aziz, Lucio Calcagnile, Anna Paola Caricato, Roberto Catalano, Deborah Chila, Giuseppe Antonio Pablo Cirrone, Tomasso Croci, Giacomo Cuttone, Sylvain Dunand, Michele Fabi, Luca Frontini, Catia Grimani, Maria Ionica, Keida Kanxheri, Valentino Liberali, Martino Maurizio, Giuseppe Maruccio, Giovanni Mazza, Mauro Menichelli, Anna Grazia Monteduro, Arianna Morozzi, Francesco Moscatelli, Stefania Pallotta, Daniele Passeri, Maddalena Pedio, Giada Petringa, Francesca Peverini, Lorenzo Piccolo, Pisana Placidi, Gianluca Quarta, Silvia Rizzato, Federico Sabbatini, Leonello Servoli, Alberto Stabile, Cinzia Talamonti, Jonathan Emanuel Thomet, Luca Tosti, Mattia Villani, Richard James Wheadon, Nicolas Wyrsch, Nicola Zema, Marco Petasecca
BACKGROUND: The increasing use of complex and high dose-rate treatments in radiation therapy necessitates advanced detectors to provide accurate dosimetry. Rather than relying on pre-treatment quality assurance (QA) measurements alone, many countries are now mandating the use of in vivo dosimetry, whereby a dosimeter is placed on the surface of the patient during treatment. Ideally, in vivo detectors should be flexible to conform to a patient's irregular surfaces. PURPOSE: This study aims to characterize a novel hydrogenated amorphous silicon (a-Si:H) radiation detector for the dosimetry of therapeutic x-ray beams...
March 3, 2024: Medical Physics
#29
JOURNAL ARTICLE
Manisha Bhateria, Isha Taneja, Kajal Karsauliya, Ashish Kumar Sonker, Yukihiro Shibata, Hiromi Sato, Sheelendra Pratap Singh, Akihiro Hisaka
In vitro methods are widely used in modern toxicological testing; however, the data cannot be directly employed for risk assessment. In vivo toxicity of chemicals can be predicted from in vitro data using physiologically based toxicokinetic (PBTK) modelling-facilitated reverse dosimetry (PBTK-RD). In this study, a minimal-PBTK model was constructed to predict the in-vivo kinetic profile of fenarimol (FNL) in rats and humans. The model was verified by comparing the observed and predicted pharmacokinetics of FNL for rats (calibrator) and further applied to humans...
February 29, 2024: Toxicology and Applied Pharmacology
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JOURNAL ARTICLE
Christian Burri, Simon Salzmann, Jasmin Wandel, Leonie Hoffmann, Boris Považay, Christoph Meier, Martin Frenz
Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2 , radiant exposure: 247 to 1975 mJ/µm2 ). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay...
December 1, 2023: Biomedical Optics Express
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JOURNAL ARTICLE
D Franck, O Meisenberg, T Beaumont, W Buchholz, M A López, J F Navarro, B Pérez, K Hürkamp, B Breustedt, F Vanhavere
The EIVIC project was launched in 2020, and the main goal was the organisation of a European intercomparison of in-vivo monitoring laboratories dealing with direct measurements of gamma-emitting radionuclides incorporated into the body of exposed workers. This project was organised jointly by members of EURADOS Working Group 7 on internal dosimetry (WG7), the Federal Office for Radiation Protection (BfS, Germany) and the Radioprotection and Nuclear Safety Institute (IRSN, France). The objective was to assess the implementation of individual-monitoring requirements in EU Member States on the basis of in-vivo measurements and to gain insight into the performance of in-vivo measurements using whole-body counters...
February 27, 2024: Radiation and Environmental Biophysics
#32
JOURNAL ARTICLE
Sonja Wegener, Stefan Weick, Robert Schindhelm, Jörg Tamihardja, Otto A Sauer, Gary Razinskas
MOTIVATION: Online adaptive radiotherapy with Ethos is based on the anatomy determined from daily cone beam computed tomography (CBCT) images. Dose optimization and computation are performed on the density map of a synthetic CT (sCT), a deformable registration of the initial planning CT (pCT) onto the current CBCT. Large density changes as present in the lung region are challenging the system. METHODS: Treatment plans for Ethos were created and delivered for 1, 2, and 3 cm diameter lung lesions in an anthropomorphic phantom, combining different insets in the pCT and during adaptive and non-adaptive treatment sessions...
February 22, 2024: Journal of Applied Clinical Medical Physics
#33
JOURNAL ARTICLE
Shreya Bendre, Helen Merkens, Hsiou-Ting Kuo, Pauline Ng, Antonio A W L Wong, Wing Sum Lau, Zhengxing Zhang, Sara Kurkowska, Chao-Cheng Chen, Carlos Uribe, François Bénard, Kuo-Shyan Lin
Fibroblast activation protein-α (FAP) is a marker of cancer-associated fibroblasts (CAFs) that constitute a significant portion of most carcinomas. Since it plays a critical role in tumor growth and metastasis, its timely detection to identify tumor lesions in early developmental stages using targeted radiopharmaceuticals has gained significant impetus. In the present work, two novel FAP-targeted precursors SB03178 and SB04033 comprising of an atypical benzo[h]quinoline construct were synthesized and either chelated to diagnostic radionuclide gallium-68 or therapeutic radionuclide lutetium-177, with ≥90% radiochemical purities and 22-76% decay-corrected radiochemical yields...
February 13, 2024: European Journal of Medicinal Chemistry
#34
JOURNAL ARTICLE
Anjong Florence Tikum, Jessica P Ketchemen, Alireza Doroudi, Anand K Nambisan, Hanan Babeker, Fabrice Ngoh Njotu, Humphrey Fonge
Eighty percent of colorectal cancers (CRCs) overexpress epidermal growth factor receptor (EGFR). Kirsten rat sarcoma viral oncogene (KRAS) mutations are present in 40% of CRCs and drive de novo resistance to anti-EGFR drugs. BRAF oncogene is mutated in 7%-10% of CRCs, with even worse prognosis. We have evaluated the effectiveness of [225 Ac]Ac-macropa-nimotuzumab in KRAS mutant and in KRAS wild-type and BRAFV600E mutant EGFR-positive CRC cells in vitro and in vivo. Anti-CD20 [225 Ac]Ac-macropa-rituximab was developed and used as a nonspecific radioimmunoconjugate...
February 15, 2024: Journal of Nuclear Medicine
#35
JOURNAL ARTICLE
Mabroor Ahmed, Sandra Bicher, Stephanie Elisabeth Combs, Rainer Lindner, Susanne Raulefs, Thomas E Schmid, Suzana Spasova, Jessica Stolz, Jan Jakob Wilkens, Johanna Winter, Stefan Bartzsch
Microbeam radiation therapy (MRT) is a still pre-clinical form of spatially fractionated radiotherapy, which uses an array of micrometer-wide, planar beams of X-ray radiation. The dose modulation in MRT has proven effective in the treatment of tumors while being well tolerated by normal tissue. Research on understanding the underlying biological mechanisms mostly requires large third-generation synchrotrons. In this study, we aimed to develop a preclinical treatment environment that would allow MRT independent of synchrotrons...
January 30, 2024: Cancers
#36
JOURNAL ARTICLE
Anders Josefsson, Angel G Cortez, Jing Yu, Sunipa Majumdar, Abhinav Bhise, Robert F Hobbs, Jessie R Nedrow
Patients with HER2-positive and triple negative breast cancer (TNBC) are associated with increased risk to develop metastatic disease including reoccurring disease that is resistant to standard and targeted therapies. The αV β3 has been implicated in BC including metastatic disease. The aims of this study were to investigate the potential of αV β3 -targeted peptides to deliver radioactive payloads to BC tumors expressing αV β3 on the tumor cells or limited to the tumors' neovascular...
February 6, 2024: Nuclear Medicine and Biology
#37
JOURNAL ARTICLE
Nils Florian Trautwein, Johannes Schwenck, Christian Seitz, Ferdinand Seith, Eduardo Calderón, Sebastian von Beschwitz, Stephan Singer, Gerald Reischl, Rupert Handgretinger, Jürgen Schäfer, Peter Lang, Bernd J Pichler, Johannes H Schulte, Christian la Fougère, Helmut Dittmann
Background: The tumor-associated disialoganglioside GD2 is a bona fide immunotherapy target in neuroblastoma and other childhood tumors, including Ewing sarcoma and osteosarcoma. GD2-targeting antibodies proved to be effective in neuroblastoma and GD2-targeting chimeric antigen receptors (CAR)- expressing T cells as well as natural killer T cells (NKTs) are emerging. However, assessment of intra- and intertumoral heterogeneity has been complicated by ineffective immunohistochemistry as well as sampling bias in disseminated disease...
2024: Theranostics
#38
JOURNAL ARTICLE
Rydlova Gabriela, Vozandychova Vera, Rehulka Pavel, Rehulkova Helena, Sirak Igor, Davidkova Marie, Markova Marketa, Myslivcova-Fucikova Alena, Tichy Ales
The increased risk of acute large-scale radiological exposure for the world's population underlines the need for optimal radiation biomarkers. Ionizing radiation triggers a complex response by the genome, proteome, and metabolome, all of which have been reported as suitable indicators of radiation-induced damage in vivo. This study analyzed peripheral blood samples from total-body irradiation (TBI) leukemia patients through mass spectrometry (MS) to identify and quantify differentially regulated proteins in plasma before and after irradiation...
February 5, 2024: Radiation Research
#39
JOURNAL ARTICLE
Daline Tho, Cédric Bélanger, Erik B Jørgensen, Jérémie Tanguay, Haydee M L Rosales, Sam Beddar, Jacob G Johansen, Gustavo Kertzscher, Marie-Claude Lavallée, Luc Beaulieu
PURPOSE: To use quantities measurable during in vivo dosimetry to build unique channel identifiers, that enable detection of brachytherapy errors. MATERIALS AND METHODS: Treatment plan of 360 patients with prostate cancer who underwent high-dose-rate brachytherapy (range, 16-25 catheters; mean, 17) were used. A single point virtual dosimeter was placed at multiple positions within the treatment geometry, and the source-dosimeter distance and dwell time were determined for each dwell position in each catheter...
January 27, 2024: Brachytherapy
#40
REVIEW
Anil Sethi, Sebastien Gros, Patrik Brodin, Beth Ghavidel, Xuedong Chai, Marija Popovic, Wolfgang Axel Tomé, Samuel Trichter, Xiaofeng Yang, Hualin Zhang, Valery Uhl
This report covers clinical implementation of a low kV intraoperative radiation therapy (IORT) program with the INTRABEAM® System (Carl Zeiss Meditec AG, Jena, Germany). Based on collective user experience from eight institutions, we discuss best methods of INTRABEAM quality assurance (QA) tests, commissioning measurements, clinical workflow, treatment planning, and potential avenues for research. The guide provides pertinent background information and clinical justification for IORT. It describes the INTRABEAM system and commissioning measurements along with a TG100 risk management analysis to ensure safety and accuracy of the IORT program...
January 26, 2024: Journal of Applied Clinical Medical Physics
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