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in-vivo dosimetry

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https://www.readbyqxmd.com/read/28314198/automated-segmentation-of-mr-imaging-to-determine-normative-central-nervous-system-cerebrospinal-fluid-volumes-in-healthy-volunteers
#1
J Levi Chazen, Jonathan P Dyke, Robert W Holt, Laura Horky, Rachel A Pauplis, Jacob Y Hesterman, P David Mozley, Ajay Verma
An accurate non-invasive method to determine total body cerebrospinal fluid volume has a number of potential diagnostic and therapeutic applications. Herein we describe a technique for automated segmentation of total body MRI data to determine cranial and spinal CSF volume in 15 healthy adults. These in vivo estimates of CSF volume exceed the standard reported volume of 150mL in human adults and provide normative data for diagnosis of disease states such as hydrocephalus and therapy including pharmacologic dosimetry...
March 2, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28306552/precise-determination-of-the-heat-delivery-during-in-vivo-magnetic-nanoparticle-hyperthermia-with-infrared-thermography
#2
Harley Rodrigues, Gustavo Capistrano, Francyelli Mello, Nicholas Zufelato, Elisangela Silveira-Lacerda, Andris F Bakuzis
Monitoring noninvasively and in real-time the heat delivery during magnetic nanoparticle hyperthermia is of fundamental importance to predict clinical outcome for cancer treatment. Infrared thermography (IRT) can inform the surface temperature due to three-dimensional heat delivery inside a subcutaneous tumor, an argument that is supported by numerical simulations. However, for precise temperature determination, it is of crucial relevance to use a correct experimental configuration. This work reports a magnetic nanoparticle hyperthermia study (MNH) using a sarcoma 180 murine tumor containing 3...
March 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28302759/preclinical-evaluation-of-11-c-sarcosine-as-a-substrate-of-proton-coupled-amino-acid-transporters-and-first-human-application-in-prostate-cancer
#3
Morand Piert, Xia Shao, David M Raffel, Mathew S Davenport, Jeffrey Montgomery, Lakshmi Kunju, Brian G Hockley, Javed Siddiqui, Peter J H Scott, Arul Chinnaiyan, Thekkelnaycke Rajandiran
Sarcosine is a known substrate of proton-coupled amino acid transporters (PAT), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness and progression. Methods: Carbon-11 radiolabeled sarcosine ((11)C-sarcosine) was tested as a new positron emission tomography (PET) imaging probe in comparison with (11)C-choline in two prostate cancer tumor xenograft models (DU-145 and PC-3)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302144/a-dosimetric-model-for-the-heterogeneous-delivery-of-radioactive-nanoparticles-in-vivo-a-feasibility-study
#4
Andrew B Satterlee, Peter Attayek, Bentley Midkiff, Leaf Huang
ᅟ: Accurate and quantitative dosimetry for internal radiation therapy can be especially challenging, given the heterogeneity of patient anatomy, tumor anatomy, and source deposition. Internal radiotherapy sources such as nanoparticles and monoclonal antibodies require high resolution imaging to accurately model the heterogeneous distribution of these sources in the tumor. The resolution of nuclear imaging modalities is not high enough to measure the heterogeneity of intratumoral nanoparticle deposition or intratumoral regions, and mathematical models do not represent the actual heterogeneous dose or dose response...
March 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28297338/epid-based-in-vivo-dosimetry-system-clinical-experience-and-results
#5
Sofia Celi, Emilie Costa, Claas Wessels, Alejandro Mazal, Alain Fourquet, Pascal Francois
Mandatory in several countries, in vivo dosimetry has been recognized as one of the next milestones in radiation oncology. Our department has implemented clinically an EPID based in vivo dosimetry system, EPIgray, by DOSISOFT S.A., since 2006. An analysis of the measurements per linac and energy over a two-year period was performed, which included a more detailed examination per technique and treatment site over a six-month period. A comparison of the treatment planning system doses and the doses estimated by EPIgray shows a mean of the differences of 1...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297336/effect-of-electron-contamination-on-in-vivo-dosimetry-for-lung-block-shielding-during-tbi
#6
Ganesh Narayanasamy, Wilbert Cruz, Daniel L Saenz, Sotirios Stathakis, Niko Papanikolaou, Neil Kirby
Our institution performs in vivo verification measurement for each of our total body irradiation (TBI) patients with optically stimulated luminescent dosimeters (OSLD). The lung block verification measurements were commonly higher than expected. The aim of this work is to understand this discrepancy and improve the accuracy of these lung block verification measurements. Initially, the thickness of the lung block was increased to provide adequate lung sparing. Further tests revealed the increase was due to electron contamination dose emanating from the lung block...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297294/real-time-in-vivo-dosimetry-for-sbrt-prostate-treatment-using-plastic-scintillating-dosimetry-embedded-in-a-rectal-balloon-a-case-study
#7
Justin L Cantley, Chee-Wai Cheng, Fredrick B Jesseph, Tarun K Podder, Valdir C Colussi, Bryan J Traughber, Lee E Ponsky, Rodney J Ellis
A novel FDA approved in vivo dosimetry device system using plastic scintillating detectors placed in an endorectal balloon to provide real-time in vivo dosimetry for prostatic rectal interface was tested for use with stereotactic body radiotherapy (SBRT). The system was used for the first time ever to measure dose during linear accelerator based SBRT. A single patient was treated with a total dose of 36.25 Gy given in 5 fractions. Delivered dose was measured for each treatment with the detectors placed against the anterior rectal wall near the prostate rectal interface...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297286/the-dose-penumbra-of-a-custom-made-shield-used-in-hemibody-skin-electron-irradiation
#8
Charlotte I Rivers, Ismail AlDahlawi, Iris Z Wang, Anurag K Singh, Matthew B Podgorsak
We report our technique for hemibody skin electron irradiation with a custom-made plywood shield. The technique is similar to our clinical total skin electron irradiation (TSEI), performed with a six-pair dual field (Stanford technique) at an extended source-to-skin distance (SSD) of 377 cm, with the addition of a plywood shield placed at 50 cm from the patient. The shield is made of three layers of standard 5/8" thick plywood (total thickness of 4.75 cm) that are clamped securely on an adjustable-height stand...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291159/67cu-radiolabeling-of-a-multimeric-rgd-peptide-for-%C3%AE-v%C3%AE-3-integrin-targeted-radionuclide-therapy-stability-therapeutic-efficacy-and-safety-studies-in-mice
#9
Zhao-Hui Jin, Takako Furukawa, Tomoyuki Ohya, Mélissa Degardin, Aya Sugyo, Atsushi B Tsuji, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tatsuya Higashi, Didier Boturyn, Pascal Dumy, Tsuneo Saga
OBJECTIVE: Copper-67 (Cu) is one of the most promising radionuclides for internal radiation therapy. Globally, several projects have recently been initiated for developing innovative approaches for the large-scale production of Cu. Encouraged by these, we performed Cu-radiolabeling of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide conjugate, cyclam-RAFT-c(-RGDfK-)4, which selectively targets αVβ3 integrin (αVβ3), the transmembrane receptor involved in tumor invasion, angiogenesis, and metastasis...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28274404/in-vivo-dosimetry-with-optically-stimulated-luminescent-dosimeters-for-conformal-and-intensity-modulated-radiation-therapy-a-2-year-multicenter-cohort-study
#10
Adam C Riegel, Yu Chen, Ajay Kapur, Laura Apicello, Abraham Kuruvilla, Anthony J Rea, Abolghassem Jamshidi, Louis Potters
PURPOSE: Optically stimulated luminescent dosimeters (OSLDs) are utilized for in vivo dosimetry (IVD) of modern radiation therapy techniques such as intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). Dosimetric precision achieved with conventional techniques may not be attainable. In this work, we measured accuracy and precision for a large sample of clinical OSLD-based IVD measurements. METHODS AND MATERIALS: Weekly IVD measurements were collected from 4 linear accelerators for 2 years and were expressed as percent differences from planned doses...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28273495/-99m-tc-labeling-and-evaluation-of-a-hynic-modified-small-molecular-inhibitor-of-prostate-specific-membrane-antigen
#11
Xiaoping Xu, Jianping Zhang, Silong Hu, Simin He, Xiao Bao, Guang Ma, Jianmin Luo, Jingyi Cheng, Yingjian Zhang
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is a well-established target in the development of radiopharmaceuticals for the diagnosis and therapy of prostate cancer (PCa). In this study, we evaluated a novel (99m)Tc-labeled small molecular inhibitor of PSMA. METHODS: This new small-molecular inhibitor of PSMA, 6-hydrazinonicotinate-Aminocaproic acid-Lysine-Urea-Glutamate (HYNIC-ALUG) was radiolabeled by (99m)Tc and was evaluated both in vitro and in vivo using PCa models (PC-3 and LNCaP)...
January 28, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28256929/a-method-for-evaluating-treatment-quality-using-in-vivo-epid-dosimetry-and-statistical-process-control-in-radiation-therapy
#12
Todsaporn Fuangrod, Peter B Greer, John Simpson, Benjamin J Zwan, Richard H Middleton
Purpose Due to increasing complexity, modern radiotherapy techniques require comprehensive quality assurance (QA) programmes, that to date generally focus on the pre-treatment stage. The purpose of this paper is to provide a method for an individual patient treatment QA evaluation and identification of a "quality gap" for continuous quality improvement. Design/methodology/approach A statistical process control (SPC) was applied to evaluate treatment delivery using in vivo electronic portal imaging device (EPID) dosimetry...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28252444/real-time-dosimetry-with-yb-doped-silica-optical-fibres
#13
Ivan Veronese, Norberto Chiodini, Simone Cialdi, Eduardo D'Ippolito, Mauro Fasoli, Salvatore Gallo, Stefano La Torre, Eleonora Mones, Anna Vedda, Gianfranco Loi
Over the years, many efforts have been done to develop radiation detectors to afford the complex issues of small field dosimetry and to fulfil the needs of increasing accuracy, precision and in-vivo dose monitoring required by the new advanced treatment modalities. In this context, a growing interest has surged in the development of sensors based on scintillating optical fibres. In this paper, the near-infrared radioluminescence and dosimetric properties of Yb-doped silica optical fibres, coupled with a laboratory prototype based on an avalanche photo-diode, were studied by irradiating the fibres with photons and electron beams generated by a Varian Trilogy accelerator...
March 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28241841/real-time-in-vivo-rectal-wall-dosimetry-using-moskin-detectors-during-linac-based-stereotactic-radiotherapy-with-rectal-displacement
#14
Kimberley Legge, Peter B Greer, Daryl J O'Connor, Lee Wilton, Matthew Richardson, Perry Hunter, Alex Wilfert, Jarad Martin, Anatoly Rosenfeld, Dean Cutajar
BACKGROUND: MOSFET dosimetry is a method that has been used to measure in-vivo doses during brachytherapy treatments and during linac based radiotherapy treatment. Rectal displacement devices (RDDs) allow for safe dose escalation for prostate cancer treatment. This study used dual MOSkin detectors to assess real-time in vivo rectal wall dose in patients with an RDD in place during a high dose prostate stereotactic body radiation therapy (SBRT) boost trial. METHODS: The PROMETHEUS study commenced in 2014 and provides a prostate SBRT boost dose with a RDD in place...
February 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28205452/in-vivo-dosimetry-in-uk-external-beam-radiotherapy-current-and-future-usage
#15
Niall D MacDougall, Michael Graveling, Vibeke N Hansen, Kevin Brownsword, Andrew Morgan
OBJECTIVE: Towards Safer Radiotherapy recommended that radiotherapy (RT) centres should have protocols in place for in vivo dosimetry (IVD) monitoring at the beginning of patient treatment courses (Donaldson S. Towards safer radiotherapy. R Coll Radiol 2008). This report determines IVD implementation in the UK in 2014, the methods used and makes recommendations on future use. METHODS: Evidence from peer-reviewed journals was used in conjunction with the first survey of UK RT centre IVD practice since the publication of Towards Safer Radiotherapy...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28194655/practical-time-considerations-for-optically-stimulated-luminescent-dosimetry-osld-in-total-body-irradiation
#16
Martin Butson, Mamoon Haque, Leon Smith, Ethan Butson, David Odgers, Dane Pope, Tina Gorjiana, May Whitaker, Johnny Morales, Angela Hong, Robin Hill
Total body irradiation (TBI) treatments are used to treat the whole body in preparation for hematopoietic stem cell (or bone marrow) transplantation. Our standard clinical regimen is a 12 Gy in 6 fraction, bi-daily technique using 6 MV X-rays at an extended Source-to-Surface distance (SSD) of 300 cm. Utilizing these characteristics, the beam dose rate is reduced below 7 cGy/min as is standard for TBI treatment. Dose received by the patient is monitored using optically stimulated luminescent dosimetry (OSLD)...
February 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28193503/clinical-translation-of-a-psma-inhibitor-for-99m-tc-based-spect
#17
Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O García-Pérez
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. (68)Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare (99m)Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ((99m)Tc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as the (99m)Tc-EDDA/HYNIC-iPSMA normal biodistribution in humans and the preliminary uptake in patients with prostate cancer...
February 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28193241/present-state-and-issues-in-iort-physics
#18
REVIEW
Frank W Hensley
Literature was reviewed to assess the physical aspects governing the present and emerging technologies used in intraoperative radiation therapy (IORT). Three major technologies were identified: treatment with electrons, treatment with external generators of kV X-rays and electronic brachytherapy. Although also used in IORT, literature on brachytherapy with radioactive sources is not systematically reviewed since an extensive own body of specialized literature and reviews exists in this field. A comparison with radioactive sources is made in the use of balloon catheters for partial breast irradiation where these are applied in almost an identical applicator technique as used with kV X-ray sources...
January 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28166056/on-the-in-vivo-photochemical-rate-parameters-for-pdt-reactive-oxygen-species-modeling
#19
Michele M Kim, Ashwini A Ghogare, Alexander Greer, Timothy C Zhu
Photosensitizer photochemical parameters are crucial data in accurate dosimetry for photodynamic therapy (PDT) based on photochemical modeling. Progress has been made in the last few decades in determining the photochemical properties of commonly used photosensitizers (PS), but mostly in solution or in vitro. Recent developments allow for the estimation of some of these photochemical parameters in vivo. This review will cover the currently available in vivo photochemical properties of photosensitizers as well as the techniques for measuring those parameters...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28143574/feasibility-of-real-time-mr-thermal-dose-mapping-for-predicting-radiofrequency-ablation-outcome-in-the-myocardium-in-vivo
#20
Solenn Toupin, Pierre Bour, Matthieu Lepetit-Coiffé, Valéry Ozenne, Baudouin Denis de Senneville, Rainer Schneider, Alexis Vaussy, Arnaud Chaumeil, Hubert Cochet, Frédéric Sacher, Pierre Jaïs, Bruno Quesson
BACKGROUND: Clinical treatment of cardiac arrhythmia by radiofrequency ablation (RFA) currently lacks quantitative and precise visualization of lesion formation in the myocardium during the procedure. This study aims at evaluating thermal dose (TD) imaging obtained from real-time magnetic resonance (MR) thermometry on the heart as a relevant indicator of the thermal lesion extent. METHODS: MR temperature mapping based on the Proton Resonance Frequency Shift (PRFS) method was performed at 1...
January 25, 2017: Journal of Cardiovascular Magnetic Resonance
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