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https://www.readbyqxmd.com/read/29658563/preclinical-evaluation-of-a-novel-engineered-recombinant-human-anti-cd44v6-antibody-for-potential-use-in-radio-immunotherapy
#1
Anja C Mortensen, Diana Spiegelberg, Anna-Karin Haylock, Hans Lundqvist, Marika Nestor
CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either 177Lu or 131I as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with 177Lu, 125I or 131I. The therapeutic effects of 177Lu-AbN44v6 and 131I-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29658397/inflammation-coagulation-response-and-thrombotic-effects-induced-by-silica-nanoparticles-in-zebrafish-embryos
#2
Junchao Duan, Shuang Liang, Yang Yu, Yang Li, Lijing Wang, Zehao Wu, Yueyue Chen, Mark R Miller, Zhiwei Sun
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica nanoparticles (SiNPs) could induce vascular endothelial damage. However, the subsequent toxicologic response to SiNPs-induced endothelial damage was still largely unknown. In this study, we explored the inflammation-coagulation response and thrombotic effects of SiNPs in endothelial cells and zebrafish embryos. For in vitro study, swollen mitochondria and autophagosome were observed in ultrastructural analysis...
April 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29609819/exradin-w1-plastic-scintillation-detector-for-in-vivo-skin-dosimetry-in-passive-scattering-proton-therapy
#3
Fahed Alsanea, Landon Wootton, Narayan Sahoo, Rajat Kudchadker, Usama Mahmood, Sam Beddar
In vivo skin dosimetry is desirable in passive scattering proton therapy because of the possibility of high entrance dose with a small number of fields. However, suitable detectors are needed to determine skin dose in proton therapy. Plastic scintillation detectors (PSDs) are particularly well suited for applications in proton therapy because of their water equivalence, small size, and ease of use. We investigated the utility of the Exradin W1, a commercially available PSD, for in vivo skin dosimetry during passive scattering proton therapy...
March 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29594217/treatment-constraints-for-single-dose-external-beam-preoperative-partial-breast-irradiation-in-early-stage-breast-cancer
#4
Ramona K Charaghvandi, Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H J G van den Bongard, Janet K Horton
Background: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. Purpose: Develop practical guidelines for single dose external beam preoperative APBI...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29584651/molecular-binding-contributes-to-concentration-dependent-acrolein-deposition-in-rat-upper-airways-cfd-and-molecular-dynamics-analyses
#5
Jinxiang Xi, Qin Hu, Linlin Zhao, Xiuhua April Si
Existing in vivo experiments show significantly decreased acrolein uptake in rats with increasing inhaled acrolein concentrations. Considering that high-polarity chemicals are prone to bond with each other, it is hypothesized that molecular binding between acrolein and water will contribute to the experimentally observed deposition decrease by decreasing the effective diffusivity. The objective of this study is to quantify the probability of molecular binding for acrolein, as well as its effects on acrolein deposition, using multiscale simulations...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29558363/signal-intensity-analysis-and-optimization-for-i-in-vivo-i-imaging-of-cherenkov-and-excited-luminescence
#6
Ethan Phillip M LaRochelle, Jennifer R Shell, Jason R Gunn, Scott C Davis, Brian W Pogue
During external beam radiotherapy (EBRT), in vivo Cherenkov optical emissions can be used as a dosimetry tool or to excite luminescence, termed Cherenkov-excited luminescence (CEL) with microsecond-level time-gated cameras. The goal of this work was to develop a complete theoretical foundation for the detectable signal strength, in order to provide guidance on optimization of the limits of detection and how to optimize near real time imaging. The key parameters affecting photon production, propagation and detection were considered and experimental validation with both tissue phantoms and a murine model are shown...
March 20, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29550875/intelligent-testing-strategy-and-analytical-techniques-for-the-safety-assessment-of-nanomaterials
#7
REVIEW
Rui Chen, Jiyan Qiao, Ru Bai, Yuliang Zhao, Chunying Chen
Nanomaterials (NMs) are widely used in various areas because of their unique and useful physicochemical properties. However, they may pose toxicity risks to human health after exposure. Applicable and reliable approaches are needed for risk assessment of NMs. Herein, an intelligent analytical strategy for safety assessment of NMs is proposed that focuses on toxicity assessment using an in vitro cell model. The toxicity assessment by testing on the adverse outcome pathway in a cell culture system was defined by application of a tiered testing approach...
March 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29502416/click-mediated-pretargeted-radioimmunotherapy-of-colorectal-carcinoma
#8
Rosemery Membreno, Brendon E Cook, Kimberly Fung, Jason S Lewis, Brian M Zeglis
Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) represents a promising strategy for leveraging the affinity and specificity of antibodies without their pharmacokinetic drawbacks. Herein, we present an investigation of the in vivo efficacy and dosimetry of a PRIT strategy for colorectal carcinoma based on the ligation between a177 Lu-labeled Tz radioligand (177 Lu-DOTA-PEG7 -Tz) and a TCO-bearing immunoconjugate of the huA33 antibody (huA33-TCO)...
March 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29485430/-44sc-sc-psma-617-biodistribution-and-dosimetry-in-patients-with-metastatic-castration-resistant-prostate-carcinoma
#9
Ambreen Khawar, Elisabeth Eppard, Jean Phlippe Sinnes, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh
AIM: [Sc]Sc-PSMA-617 with 3.9-hour half-life, in vitro and in vivo characteristics similar to [Lu]Lu-PSMA-617 and possibility of delayed imaging after 24 hours or later, implies it to be advantageous than [ Ga]Ga-PSMA-617 for pretherapeutic dosimetric assessment for [Lu]Lu-PSMA-617 in metastatic castration-resistant prostate carcinoma (mCRPC) patients. In this study, we investigated biodistribution and radiation exposure to normal organs with [Sc]Sc-PSMA-617 in mCRPC patients. METHODS: Five mCRPC patients (mean age, 69 years) enrolled for [Lu]Lu-PSMA-617 therapy were injected with 40-62 MBq [Sc]Sc-PSMA-617 intravenously; Siemens Biograph 2 PET/CT system was used to acquire dynamic PET data (30 minutes) in list mode over the abdomen, followed by the collection of static PET/CT images (skull to mid-thigh) at 45 minutes, 2 and approximately 20 hours postinjection...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29474504/the-first-in-vivo-multiparametric-comparison-of-different-radiation-exposure-biomarkers-in-human-blood
#10
Ales Tichy, Sylwia Kabacik, Grainne O'Brien, Jaroslav Pejchal, Zuzana Sinkorova, Adela Kmochova, Igor Sirak, Andrea Malkova, Caterina Gomila Beltran, Juan Ramon Gonzalez, Jakub Grepl, Matthaeus Majewski, Elizabeth Ainsbury, Lenka Zarybnicka, Jana Vachelova, Alzbeta Zavrelova, Marie Davidkova, Marketa Markova Stastna, Michael Abend, Eileen Pernot, Elisabeth Cardis, Christophe Badie
The increasing risk of acute large-scale radiological/nuclear exposures of population underlines the necessity of developing new, rapid and high throughput biodosimetric tools for estimation of received dose and initial triage. We aimed to compare the induction and persistence of different radiation exposure biomarkers in human peripheral blood in vivo. Blood samples of patients with indicated radiotherapy (RT) undergoing partial body irradiation (PBI) were obtained soon before the first treatment and then after 24 h, 48 h, and 5 weeks; i...
2018: PloS One
https://www.readbyqxmd.com/read/29456472/electron-beam-intraoperative-radiotherapy-eliot-in-pregnant-women-with-breast-cancer-from-in-vivo-dosimetry-to-clinical-practice
#11
Maria Leonardi, Agnese Cecconi, Rosa Luraschi, Elena Rondi, Federica Cattani, Roberta Lazzari, Anna Morra, Santos Soto, Vanna Zanagnolo, Viviana Galimberti, Oreste Gentilini, Fedro Peccatori, Barbara Jereczek-Fossa, Roberto Orecchia
Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29454148/-68-ga-galmydar-biodistribution-and-radiation-dosimetry-studies-in-rodents
#12
Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma
INTRODUCTION: 68 Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68 Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging...
December 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29452866/intrapatient-study-comparing-3d-printed-bolus-versus-standard-vinyl-gel-sheet-bolus-for-postmastectomy-chest-wall-radiation-therapy
#13
James L Robar, Kathryn Moran, James Allan, James Clancey, Tami Joseph, Krista Chytyk-Praznik, R Lee MacDonald, John Lincoln, Parisa Sadeghi, Robert Rutledge
PURPOSE: This patient study evaluated the use of 3-dimensional (3D) printed bolus for chest wall radiation therapy compared with standard sheet bolus with regard to accuracy of fit, surface dose measured in vivo, and efficiency of patient setup. By alternating bolus type over the course of therapy, each patient served as her own control. METHODS AND MATERIALS: For 16 patients undergoing chest wall radiation therapy, a custom 5.0 mm thick bolus was designed based on the treatment planning computed tomography scan and 3D printed using polylactic acid...
December 24, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29432473/setup-in-a-clinical-workflow-and-impact-on-radiotherapy-routine-of-an-in-vivo-dosimetry-procedure-with-an-electronic-portal-imaging-device
#14
Jie Li, Angelo Piermattei, Pei Wang, Shengwei Kang, Mingyong Xiao, Bin Tang, Xiongfei Liao, Xin Xin, Mattia Grusio, Lucia Clara Orlandini
High conformal techniques such as intensity-modulated radiation therapy and volumetric-modulated arc therapy are widely used in overloaded radiotherapy departments. In vivo dosimetric screening is essential in this environment to avoid important dosimetric errors. This work examines the feasibility of introducing in vivo dosimetry (IVD) checks in a radiotherapy routine. The causes of dosimetric disagreements between delivered and planned treatments were identified and corrected during the course of treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29413751/evaluation-of-18f-fnm-biodistribution-and-dosimetry-based-on-whole-body-pet-imaging-of-rats
#15
Anne-Sophie Salabert, Erick Mora-Ramirez, Marie Beaurain, Mathieu Alonso, Charlotte Fontan, Hafid Belhadj Tahar, Marie Laure Boizeau, Mathieu Tafani, Manuel Bardiès, Pierre Payoux
INTRODUCTION: The aim of this work was to study the biodistribution, metabolism and radiation dosimetry of rats injected with [18F]FNM using PET/CT images. This novel radiotracer targeting NMDA receptor has potential for investigation for neurological and psychiatric diseases. METHODS: Free fraction and stability in fresh human plasma were determined in vitro. PET/CT was performed on anesthetized rats. Organs were identified and 3D volumes of interest (VOIs) were manually drawn on the CT in the center of each organ...
December 21, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29368623/isd3-a-particokinetic-model-for-predicting-the-combined-effects-of-particle-sedimentation-diffusion-and-dissolution-on-cellular-dosimetry-for-in-vitro-systems
#16
Dennis G Thomas, Jordan N Smith, Brian D Thrall, Donald R Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen, Justin G Teeguarden
BACKGROUND: The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard ranking from high-throughput systems, and now allows for translation of exposures across in vitro and in vivo test systems. Complimentary particokinetic models that address processes controlling delivery of both particles and released ions to cells, and the influence of particle size changes from dissolution on particle delivery for cell-culture systems would help advance our understanding of the role of particles and ion dosimetry on cellular toxicology...
January 25, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29350236/dose-optimization-of-total-or-partial-skin-electron-irradiation-by-thermoluminescent-dosimetry
#17
Lars Schüttrumpf, Klement Neumaier, Cornelius Maihoefer, Maximilian Niyazi, Ute Ganswindt, Minglun Li, Peter Lang, Michael Reiner, Claus Belka, Stefanie Corradini
BACKGROUND: Due to the complex surface of the human body, total or partial skin irradiation using large electron fields is challenging. The aim of the present study was to quantify the magnitude of dose optimization required after the application of standard fields. METHODS: Total skin electron irradiation (TSEI) was applied using the Stanford technique with six dual-fields. Patients presenting with localized lesions were treated with partial skin electron irradiation (PSEI) using large electron fields, which were individually adapted...
January 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29333465/in-vivo-exposure-effects-of-99m-tc-methoxyisobutylisonitrile-on-the-fdxr-and-xpa-genes-expression-in-human-peripheral-blood-lymphocytes
#18
Mohammad Taghi Bahreyni-Toossi, Habibeh Vosoughi, Hosein Azimian, Abdul Rahim Rezaei, Mehdi Momennezhad
Objectives: In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radiation. In order to detect molecular changes, high-sensitivity techniques must be utilized. The aim of this study was to assess the effect of a low-dose (below 10 mSv) gamma ray on gene expression using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29330552/dosimetry-prediction-for-clinical-translation-of-64-cu-pembrolizumab-immunopet-targeting-human-pd-1-expression
#19
Arutselvan Natarajan, Chirag B Patel, Frezghi Habte, Sanjiv S Gambhir
The immune checkpoint programmed death 1 receptor (PD-1) expressed on some tumor-infiltrating lymphocytes, and its ligand (PD-L1) expressed on tumor cells, enable cancers to evade the immune system. Blocking PD-1 with the monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying the presence of PD-1 expression in the tumor microenvironment prior to initiation of immune checkpoint blockade may identify the patients likely to respond to therapy. We have developed a 64 Cu-pembrolizumab radiotracer and evaluated human dosimetry...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314080/a-simple-model-for-transit-dosimetry-based-on-a-water-equivalent-epid
#20
S Deshpande, S J Blake, A Xing, P E Metcalfe, L C Holloway, P Vial
PURPOSE: The aim of this study was to demonstrate a new model for implementing a transit dosimetry system as a means of in vivo dose verification with a water equivalent electronic portal imaging device (WE-EPID) and a conventional treatment planning system (TPS). METHOD AND MATERIALS: A standard amorphous silicon (a-Si) EPID was modified to a WE-EPID configuration by replacing the metal-plate/phosphor screen situated above the photodiode detector with a 3 cm thick water equivalent plastic x ray converter material...
March 2018: Medical Physics
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