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in-vivo dosimetry

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https://www.readbyqxmd.com/read/28721684/pharmacokinetics-microscale-distribution-and-dosimetry-of-alpha-emitter-labeled-anti-pd-l1-antibodies-in-an-immune-competent-transgenic-breast-cancer-model
#1
Jessie R Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, George Sgouros
BACKGROUND: Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted delivery of high LET radiation to the tumor microenvironment via an immune checkpoint inhibitor. METHODS: The impact of protein concentration on the distribution of (111)In-DTPA-anti-PD-L1-BC, an (111)In-antibody conjugate targeted to PD-L1, was evaluated in an immunocompetent mouse model of breast cancer...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28714454/a-back-projection-algorithm-in-the-presence-of-an-extra-attenuating-medium-towards-epid-dosimetry-for-the-mr-linac
#2
I Torres-Xirau, I Olaciregui-Ruiz, R A Rozendaal, P González, B J Mijnheer, J-J Sonke, U A van der Heide, A Mans
In external beam radiotherapy, electronic portal imaging devices (EPIDs) are frequently used for pre-treatment and for in vivo dose verification. Currently, various MR-guided radiotherapy systems are being developed and clinically implemented. Independent dosimetric verification is highly desirable. For this purpose we adapted our EPID-based dose verification system for use with the MR-Linac combination developed by Elekta in cooperation with UMC Utrecht and Philips. In this study we extended our back-projection method to cope with the presence of an extra attenuating medium between the patient and the EPID...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28712278/in-vivo-dosimetry-and-acute-toxicity-in-breast-cancer-patients-undergoing-intraoperative-radiotherapy-as-boost
#3
Jason Joon Bock Lee, Jinhyun Choi, Sung Gwe Ahn, Joon Jeong, Ik Jae Lee, Kwangwoo Park, Kangpyo Kim, Jun Won Kim
PURPOSE: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28696500/development-of-a-silicon-diode-detector-for-skin-dosimetry-in-radiotherapy
#4
Nikolina Vicoroski, Anthony Espinoza, Mitchell Duncan, Bradley Michael Oborn, Martin Carolan, Peter Metcalfe, David Menichelli, Vladimir L Perevertaylo, Michael L F Lerch, Anatoly B Rosenfeld, Marco Petasecca
PURPOSE: The aim of in-vivo skin dosimetry is to measure the absorbed dose to the skin during radiotherapy, when treatment planning calculations cannot be relied on. It is of particularly importance in hypo-fractionated stereotactic modalities, where excessive dose can lead to severe skin toxicity. Currently commercial diodes for such applications are with water equivalent depths ranging from 0.5 to 0.8 mm. In this study, we investigate a new detector for skin dosimetry based on a silicon epitaxial diode, referred to as the skin diode...
July 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28663056/from-in-vitro-to-in-vivo-integration-of-the-virtual-cell-based-assay-with-physiologically-based-kinetic-modelling
#5
Alicia Paini, Jose Vicente Sala Benito, Jos Bessems, Andrew P Worth
Physiologically based kinetic (PBK) models and the virtual cell based assay can be linked to form so called physiologically based dynamic (PBD) models. This study illustrates the development and application of a PBK model for prediction of estragole-induced DNA adduct formation and hepatotoxicity in humans. To address the hepatotoxicity, HepaRG cells were used as a surrogate for liver cells, with cell viability being used as the in vitro toxicological endpoint. Information on DNA adduct formation was taken from the literature...
June 27, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28654303/imaging-and-dosimetry-for-radium-223-the-potential-for-personalized-treatment
#6
Glenn D Flux
Radium-223 ((223)Ra) offers a new option for the treatment of bone metastases from prostate cancer. As cancer treatment progresses towards personalization, the potential for an individualized approach is exemplified in treatments with radiotherapeutics due to the unique ability to image in vivo the uptake and retention of the therapeutic agent. This is unmatched in any other field of medicine. Currently, (223)Ra is administered according to standard fixed administrations, modified according to patient weight...
June 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28643752/dosimetric-characterization-of-optically-stimulated-luminescence-dosimeter-with-therapeutic-photon-beams-for-use-in-clinical-radiotherapy-measurements
#7
Retna Ponmalar, Ravikumar Manickam, K M Ganesh, Sathiyan Saminathan, Arun Raman, Henry Finlay Godson
AIM: The modern radiotherapy techniques impose new challenges for dosimetry systems with high precision and accuracy in in vivo and in phantom dosimetric measurements. The knowledge of the basic characterization of a dosimetric system before patient dose verification is crucial. This incites the investigation of the potential use of nanoDot optically stimulated luminescence dosimeter (OSLD) for application in radiotherapy with therapeutic photon beams. MATERIALS AND METHODS: Measurements were carried out with nanoDot OSLDs to evaluate the dosimetric characteristics such as dose linearity, dependency on field size, dose rate, energy and source-to-surface distance (SSD), reproducibility, fading effect, reader stability, and signal depletion per read out with cobalt-60 (60 Co) beam, 6 and 18 MV therapeutic photon beams...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28641969/determining-3d-kinematics-of-the-hip-using-video-fluoroscopy-guidelines-for-balancing-radiation-dose-and-registration-accuracy
#8
Fabio D'Isidoro, Patrik Eschle, Thomas Zumbrunn, Christian Sommer, Stephan Scheidegger, Stephen J Ferguson
BACKGROUND: Video fluoroscopy is a technique currently used to retrieve the in vivo three-dimensional kinematics of human joints during activities of daily living. Minimization of the radiation dose absorbed by the subject during the measurement is a priority and has not been thoroughly addressed so far. This issue is critical for the motion analysis of the hip joint, because of the proximity of the gonads. The aims of this study were to determine the x-ray voltage and the irradiation angle that minimize the effective dose and to achieve the best compromise between delivered dose and accuracy in motion retrieval...
May 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28613198/lu-177-psma-617-prostate-specific-membrane-antigen-inhibitor-therapy-in-patients-with-castration-resistant-prostate-cancer-stability-bio-distribution-and-dosimetry
#9
Levent Kabasakal, Türkay Toklu, Nami Yeyin, Emre Demirci, Mohammad Abuqbeitah, Meltem Ocak, Aslan Aygün, Emre Karayel, Hüseyin Pehlivanoğlu, Nalan Alan Selçuk
OBJECTIVE: The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617. METHODS: For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.6 to 7.4 GBq with a mean of 5.2±1.8 GBq. The stability of radiotracer in saline was calculated up to 48 h...
June 1, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28596540/preparation-and-in-vivo-characterization-of-51-mncl2-as-pet-tracer-of-ca-2-channel-mediated-transport
#10
Stephen A Graves, Reinier Hernandez, Hector F Valdovinos, Paul A Ellison, Jonathan W Engle, Todd E Barnhart, Weibo Cai, Robert J Nickles
Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing (52g)Mn (t1/2: 5.6 d, β(+): 29%) show promise for a variety of applications including cell tracking, neural tract tracing, immunoPET, and functional β-cell mass quantification. The half-life and confounding gamma emissions of (52g)Mn are prohibitive to clinical translation, but the short-lived (51)Mn (t1/2: 46 min, β(+): 97%) represents a viable alternative...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585491/a-simple-method-for-2-d-in-vivo-dosimetry-by-portal-imaging
#11
Stefano Peca, Derek Wilson Brown, Wendy Lani Smith
PURPOSE: To improve patient safety and treatment quality, verification of dose delivery in radiotherapy is desirable. We present a simple, easy-to-implement, open-source method for in vivo planar dosimetry of conformal radiotherapy by electronic portal imaging device (EPID). METHODS: Correlation ratios, which relate dose in the mid-depth of slab phantoms to transit EPID signal, were determined for multiple phantom thicknesses and field sizes. Off-axis dose is corrected for by means of model-based convolution...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28585490/in-vivo-portal-imaging-dosimetry-identifies-delivery-errors-in-rectal-cancer-radiotherapy-on-the-belly-board-device
#12
Stefano Peca, Richie Siddhartha Sinha, Derek Wilson Brown, Wendy Lani Smith
PURPOSE: We recently developed a novel, open-source in vivo dosimetry that uses the electronic portal imaging device to detect dose delivery discrepancies. We applied our method on patients with rectal cancer treated on a belly board device. METHODS: In vivo dosimetry was performed on 10 patients with rectal cancer treated prone on the belly board with a 4-field box arrangement. Portal images were acquired approximately once per week from each treatment beam. Our dosimetry method used these images along with the planning CT to reconstruct patient planar dose at isocenter depth...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28585232/in-vitro-in-silico-based-analysis-of-the-dose-dependent-in-vivo-estrogenicity-of-the-soy-phytoestrogen-genistein-in-humans
#13
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens
BACKGROUND AND PURPOSE: In vivo estrogenicity of genistein and its glycoside genistin is still under debate. The present study aimed to develop a physiologically based kinetic (PBK) model that provides insight in dose-dependent plasma concentrations of genistein aglycone and its metabolites and enables prediction of in vivo estrogenic effective dose levels of genistein and genistin in humans. EXPERIMENTAL APPROACH: A PBK model for genistein and genistin in humans was developed based on in vitro metabolic parameters...
June 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28584811/erratum-assessment-of-a-2d-electronic-portal-imaging-devices-based-dosimetry-algorithm-for-pretreatment-and-in-vivo-midplane-dose-verification
#14
(no author information available yet)
[This corrects the article on p. 171 in vol. 5, PMID: 28028511.].
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28576581/in-vivo-dosimetry-for-lung-radiotherapy-including-sbrt
#15
REVIEW
Boyd M C McCurdy, Peter M McCowan
SBRT for lung cancer is being rapidly adopted as a treatment option in modern radiotherapy centres. This treatment is one of the most complex in common clinical use, requiring significant expertise and resources. It delivers a high dose per fraction (typically ∼6-30Gy/fraction) over few fractions. The complexity and high dose delivered in only a few fractions make powerful arguments for the application of in vivo dosimetry methods for these treatments to enhance patient safety. In vivo dosimetry is a group of techniques with a common objective - to estimate the dose delivered to the patient through a direct measurement of the treatment beam(s)...
May 30, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28574221/validation-of-a-method-for-in%C3%A2-vivo-3d-dose-reconstruction-in-sbrt-using-a-new-transmission-detector
#16
Yuji Nakaguchi, Takeshi Ono, Masato Maruyama, Yoshinobu Shimohigashi, Yudai Kai
Stereotactic body radiation therapy (SBRT) involves the delivery of substantially larger doses over fewer fractions than conventional therapy. Therefore, SBRT treatments will strongly benefit patients using vivo patient dose verification, because the impact of the fraction is large. For in vivo measurements, a commercially available quality assurance (QA) system is the COMPASS system (IBA Dosimetry, Germany). For measurements, the system uses a new transmission detector (Dolphin, IBA Dosimetry). In this study, we evaluated the method for in vivo 3D dose reconstruction for SBRT using this new transmission detector...
June 2, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28572491/new-fetal-radiation-doses-for-18-f-fdg-based-on-human-data
#17
Paolo Zanotti-Fregonara, Michael G Stabin
Current standard values of fetal dosimetry deriving from (18)F-FDG injection in pregnant women are estimated from animal data. The present communication offers a revision of fetal dosimetry values calculated from recently published human data, in which fetal (18)F-FDG uptake was directly observed in vivo. The final doses were obtained from the observed time-integrated activity coefficients and a new generation of anthropomorphic voxel-based pregnancy phantoms.
June 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28548289/effects-of-food-borne-nanomaterials-on-gastrointestinal-tissues-and-microbiota
#18
REVIEW
Hans Bouwmeester, Meike van der Zande, Mark A Jepson
Ingestion of engineered nanomaterials is inevitable due to their addition to food and prevalence in food packaging and domestic products such as toothpaste and sun cream. In the absence of robust dosimetry and particokinetic data, it is currently challenging to accurately assess the potential toxicity of food-borne nanomaterials. Herein, we review current understanding of gastrointestinal uptake mechanisms, consider some data on the potential for toxicity of the most commonly encountered classes of food-borne nanomaterials (including TiO2 , SiO2, ZnO, and Ag nanoparticles), and discuss the potential impact of the luminal environment on nanoparticle properties and toxicity...
May 26, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28536392/personalized-dosimetry-for-radionuclide-therapy-using-molecular-imaging-tools
#19
REVIEW
Michael Ljungberg, Katarina Sjögreen Gleisner
For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is labelled to a molecule that plays the active part in the localization of the tumor. Since the aim is to impart lethal damage to tumor cells while maintaining possible side-effects to normal tissues at tolerable levels, a proper and accurate personalized dosimetry should be a pre-requisite...
November 15, 2016: Biomedicines
https://www.readbyqxmd.com/read/28535921/out-of-field-in-vivo-dosimetry-using-tld-in-sabr-for-primary-kidney-cancer-involving-mixed-photon-fields
#20
P Lonski, S Keehan, S Siva, D Pham, R D Franich, M L Taylor, T Kron
PURPOSE: To assess out-of-field dose using three different variants of LiF thermoluminescence dosimeters (TLD) for ten patients who underwent stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) and compare with treatment planning system (TPS) dose calculations. METHODS AND MATERIALS: Thermoluminescent dosimeter (TLD) measurements were conducted at 20, 30, 40 and 50cm from isocentre on ten patients undergoing SABR for primary RCC...
May 2017: Physica Medica: PM
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