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in-vivo dosimetry

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https://www.readbyqxmd.com/read/29456472/electron-beam-intraoperative-radiotherapy-eliot-in-pregnant-women-with-breast-cancer-from-in-vivo-dosimetry-to-clinical-practice
#1
Maria Leonardi, Agnese Cecconi, Rosa Luraschi, Elena Rondi, Federica Cattani, Roberta Lazzari, Anna Morra, Santos Soto, Vanna Zanagnolo, Viviana Galimberti, Oreste Gentilini, Fedro Peccatori, Barbara Jereczek-Fossa, Roberto Orecchia
Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29454148/-68-ga-galmydar-biodistribution-and-radiation-dosimetry-studies-in-rodents
#2
Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma
INTRODUCTION: 68 Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68 Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging...
December 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29452866/intrapatient-study-comparing-3d-printed-bolus-versus-standard-vinyl-gel-sheet-bolus-for-postmastectomy-chest-wall-radiation-therapy
#3
James L Robar, Kathryn Moran, James Allan, James Clancey, Tami Joseph, Krista Chytyk-Praznik, R Lee MacDonald, John Lincoln, Parisa Sadeghi, Robert Rutledge
PURPOSE: This patient study evaluated the use of 3-dimensional (3D) printed bolus for chest wall radiation therapy compared with standard sheet bolus with regard to accuracy of fit, surface dose measured in vivo, and efficiency of patient setup. By alternating bolus type over the course of therapy, each patient served as her own control. METHODS AND MATERIALS: For 16 patients undergoing chest wall radiation therapy, a custom 5.0 mm thick bolus was designed based on the treatment planning computed tomography scan and 3D printed using polylactic acid...
December 24, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29432473/setup-in-a-clinical-workflow-and-impact-on-radiotherapy-routine-of-an-in-vivo-dosimetry-procedure-with-an-electronic-portal-imaging-device
#4
Jie Li, Angelo Piermattei, Pei Wang, Shengwei Kang, Mingyong Xiao, Bin Tang, Xiongfei Liao, Xin Xin, Mattia Grusio, Lucia Clara Orlandini
High conformal techniques such as intensity-modulated radiation therapy and volumetric-modulated arc therapy are widely used in overloaded radiotherapy departments. In vivo dosimetric screening is essential in this environment to avoid important dosimetric errors. This work examines the feasibility of introducing in vivo dosimetry (IVD) checks in a radiotherapy routine. The causes of dosimetric disagreements between delivered and planned treatments were identified and corrected during the course of treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29413751/evaluation-of-18f-fnm-biodistribution-and-dosimetry-based-on-whole-body-pet-imaging-of-rats
#5
Anne-Sophie Salabert, Erick Mora-Ramirez, Marie Beaurain, Mathieu Alonso, Charlotte Fontan, Hafid Belhadj Tahar, Marie Laure Boizeau, Mathieu Tafani, Manuel Bardiès, Pierre Payoux
INTRODUCTION: The aim of this work was to study the biodistribution, metabolism and radiation dosimetry of rats injected with [18F]FNM using PET/CT images. This novel radiotracer targeting NMDA receptor has potential for investigation for neurological and psychiatric diseases. METHODS: Free fraction and stability in fresh human plasma were determined in vitro. PET/CT was performed on anesthetized rats. Organs were identified and 3D volumes of interest (VOIs) were manually drawn on the CT in the center of each organ...
December 21, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29368623/isd3-a-particokinetic-model-for-predicting-the-combined-effects-of-particle-sedimentation-diffusion-and-dissolution-on-cellular-dosimetry-for-in-vitro-systems
#6
Dennis G Thomas, Jordan N Smith, Brian D Thrall, Donald R Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen, Justin G Teeguarden
BACKGROUND: The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard ranking from high-throughput systems, and now allows for translation of exposures across in vitro and in vivo test systems. Complimentary particokinetic models that address processes controlling delivery of both particles and released ions to cells, and the influence of particle size changes from dissolution on particle delivery for cell-culture systems would help advance our understanding of the role of particles and ion dosimetry on cellular toxicology...
January 25, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29350236/dose-optimization-of-total-or-partial-skin-electron-irradiation-by-thermoluminescent-dosimetry
#7
Lars Schüttrumpf, Klement Neumaier, Cornelius Maihoefer, Maximilian Niyazi, Ute Ganswindt, Minglun Li, Peter Lang, Michael Reiner, Claus Belka, Stefanie Corradini
BACKGROUND: Due to the complex surface of the human body, total or partial skin irradiation using large electron fields is challenging. The aim of the present study was to quantify the magnitude of dose optimization required after the application of standard fields. METHODS: Total skin electron irradiation (TSEI) was applied using the Stanford technique with six dual-fields. Patients presenting with localized lesions were treated with partial skin electron irradiation (PSEI) using large electron fields, which were individually adapted...
January 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29333465/in-vivo-exposure-effects-of-99mtc-methoxyisobutylisonitrile-on-the-fdxr-and-xpa-genes-expression-in-human-peripheral-blood-lymphocytes
#8
Mohammad Taghi Bahreyni-Toossi, Habibeh Vosoughi, Hosein Azimian, Abdul Rahim Rezaei, Mehdi Momennezhad
Objectives: In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radiation. In order to detect molecular changes, high-sensitivity techniques must be utilized. The aim of this study was to assess the effect of a low-dose (below 10 mSv) gamma ray on gene expression using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29330552/dosimetry-prediction-for-clinical-translation-of-64cu-pembrolizumab-immunopet-targeting-human-pd-1-expression
#9
Arutselvan Natarajan, Chirag B Patel, Frezghi Habte, Sanjiv S Gambhir
The immune checkpoint programmed death 1 receptor (PD-1) expressed on some tumor-infiltrating lymphocytes, and its ligand (PD-L1) expressed on tumor cells, enable cancers to evade the immune system. Blocking PD-1 with the monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying the presence of PD-1 expression in the tumor microenvironment prior to initiation of immune checkpoint blockade may identify the patients likely to respond to therapy. We have developed a 64Cu-pembrolizumab radiotracer and evaluated human dosimetry...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314080/a-simple-model-for-transit-dosimetry-based-on-a-water-equivalent-epid
#10
S Deshpande, S J Blake, A Xing, P E Metcalfe, L C Holloway, P Vial
PURPOSE: To demonstrate a new model for implementing a transit dosimetry system as a means of in vivo dose verification with a water-equivalent electronic portal imaging device (WE-EPID) and a conventional treatment planning system (TPS). METHOD AND MATERIALS: A standard amorphous silicon (a-Si) EPID was modified to a WE-EPID configuration by replacing the metal-plate/phosphor screen situated above the photodiode detector with a 3 cm thick water equivalent plastic x-ray converter material...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29234833/towards-a-generic-physiologically-based-kinetic-model-to-predict-in-vivo-uterotrophic-responses-in-rats-by-reverse-dosimetry-of-in-vitro-estrogenicity-data
#11
Mengying Zhang, Bennard van Ravenzwaay, Eric Fabian, Ivonne M C M Rietjens, Jochem Louisse
Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration-response data. In the present study, the potential of this approach to predict the dose-dependent increase of uterus weight in rats upon exposure to estrogenic chemicals was assessed. In vitro concentration-response data of 17β-estradiol (E2) and bisphenol A (BPA) obtained in the MCF-7/BOS proliferation assay, the U2OS ER-CALUX assay and the yeast estrogen screen (YES) assay, were translated into in vivo dose-response data in rat, using a PBK model with a minimum number of in vitro and in silico determined parameter values...
December 12, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29195567/review-of-technologies-and-procedures-of-clinical-dosimetry-for-scanned-ion-beam-radiotherapy
#12
REVIEW
S Giordanengo, L Manganaro, A Vignati
In the last few years, the use of ions in radiation therapy is gaining interest and it is being considered medically necessary for a growing subset of tumours. Concurrently, the technologies involved in a particle therapy treatment are rapidly evolving, as well as the accuracy in the dose delivery in spite of the increased complexity. Since nowadays, the pencil beam scanning technique is showing very interesting features in terms of dose conformation and overall treatment outcome, the present review is intended to summarize the main procedures, detectors and tools adopted for the clinical dose verification...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173920/evaluation-and-clinical-implementation-of-in-vivo-dosimetry-for-kv-radiotherapy-using-radiochromic-film-and-micro-silica-bead-thermoluminescent-detectors
#13
Antony L Palmer, Shakardokht M Jafari, Ioanna Mone, Sarah Muscat
PURPOSE: kV radiotherapy treatment calculations are based on flat, homogenous, full-scatter reference conditions. However, clinical treatments often include surface irregularities and inhomogeneities, causing uncertainty. Therefore, confirmation of actual delivered doses in vivo is valuable. The current study evaluates, and implements, radiochromic film and micro silica bead TLD for in vivo kV dosimetry. METHODS: The kV energy and dose response of EBT3 film and silica bead TLD was established and uncertainty budgets determined...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173910/epid-based-in-vivo-dosimetry-for-stereotactic-body-radiotherapy-of-non-small-cell-lung-tumors-initial-clinical-experience
#14
R Consorti, A Fidanzio, V Brainovich, F Mangiacotti, M De Spirito, M A Mirri, A Petrucci
PURPOSE: EPID-based in vivo dosimetry (IVD) has been implemented for stereotactic body radiotherapy treatments of non-small cell lung cancer to check both isocenter dose and the treatment reproducibility comparing EPID portal images. METHODS: 15 patients with lung tumors of small dimensions and treated with volumetric modulated arc therapy were enrolled for this initial experience. IVD tests supplied ratios R between in vivo reconstructed and planned isocenter doses...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29165319/comparison-of-forward-and-back-projection-in-vivo-epid-dosimetry-for-vmat-treatment-of-the-prostate
#15
James L Bedford, Ian Maddock Hanson, Vibeke N Hansen
In the forward-projection method of portal dosimetry for volumetric modulated arc therapy (VMAT), the integrated signal at the electronic portal imaging device (EPID) is predicted at the time of treatment planning, against which the measured integrated image is compared. In the back-projection method, the measured signal at each gantry angle is back-projected through the patient CT scan to give a measure of total dose to the patient. This study aims to investigate the practical agreement between the two types of EPID dosimetry for prostate radiotherapy...
November 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29164632/characterization-of-nanodot-optically-stimulated-luminescence-detectors-and-high-sensitivity-mcp-n-thermoluminescent-detectors-in-the-40-300-kvp-energy-range
#16
Yannick Poirier, Svetlana Kuznetsova, Jose Eduardo Villarreal-Barajas
PURPOSE: To investigate empirically the energy dependence of the detector response of two in-vivo luminescence detectors, LiF:Mg,Cu,P (MCP-N) high-sensitivity TLDs and Al2 O3 :C OSLDs, in the 40-300-kVp energy range in the context of in-vivo surface dose measurement. As these detectors become more prevalent in clinical and pre-clinical in-vivo measurements, knowledge of the variation of the empirical dependence of the measured response of these detectors across a wide spectrum of beam qualities is important...
November 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/29152840/on-the-use-of-bolus-for-pacemaker-dose-measurement-and-reduction-in-radiation-therapy
#17
Huagang Yan, Fanqing Guo, Dengsong Zhu, Stefan Stryker, Sharron Trumpore, Kenneth Roberts, Susan Higgins, Ravinder Nath, Zhe Chen, Wu Liu
Special attention is required in planning and administering radiation therapy to patients with cardiac implantable electronic devices (CIEDs), such as pacemaker and defibrillator. The range of dose to CIEDs that can induce malfunction is large among CIEDs. Clinically significant defects have been reported at dose as low as 0.15 Gy. Therefore, accurate estimation of dose to CIED and dose reduction are both important even if the dose is expected to be less than the often-used 2-Gy limit. We investigated the use of bolus in in vivo dosimetry for CIEDs...
November 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29140458/direct-measurements-of-skin-eye-lens-and-thyroid-dose-during-pediatric-brain-ct-examinations
#18
Agapi Ploussi, Ioannis Stathopoulos, Vasileios Syrgiamiotis, Triantafillia Makri, Christiana Hatzigiorgi, Kalliopi Platoni, Eleftheria Carinou, Efstathios P Efstathopoulos
Pediatric brain computed tomography (CT) is identified as the most frequent CT examination in children. The aim of the study is the direct measurement of skin, eye lens and thyroid dose in pediatric patients during brain CT examinations. The study included 35 pediatric patients who underwent brain CT examinations. The patients were categorized in three age groups: Group A (age range: 0.8-1 years), Group B (age range: 2.0-4.9 years) and Group C (age range: 5.5-15.5 years). thermoluminescent dosimeters (TLDs) were placed on the eyes, the frontal region of the head, the mastoid apophysis and the thyroid gland...
November 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29136280/transitqa-a-new-method-for-transit-dosimetry-of-tomotherapy-patients
#19
Olivier Pisaturo, Frédéric Miéville, Pierre-Alain Tercier, Abdelkarim Said Allal
PURPOSE: TransitQA is an innovative method for Tomotherapy transit dosimetry using the on-board detector (OBD). Our previously published model for Tomotherapy treatment plan verification (AirQA) has been enhanced to take into account patient and couch transmission. AirQA estimates the OBD signal during irradiation with nothing in the beam path from the leaf control sinogram, allowing us to check whether the planned treatment is correctly delivered by the machine. TransitQA allows us to check the treatment delivery with the patient on the couch, potentially showing the effects of changes in the patient anatomy and delivery errors...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29129050/metal-free-cycloaddition-chemistry-driven-pretargeted-radioimmunotherapy-using-%C3%AE-particle-radiation
#20
Manan Shah, Xiuli Zhang, Raffaella Rossin, Marc S Robillard, Darrell Fisher, Tyler Bueltmann, Freek J M Hoeben, Thomas Quinn
The pretargeted radioimmunotherapy approach (PRIT) decouples the administration of tumor targeting monoclonal antibodies (mAb) from that of the radiolabeled ligand. This multi-step strategy allows delivery of high doses of radiation to tumor cells while minimizing non-specific normal tissue irradiation. In this study, we evaluated the potential of pretargeted α-particle radioimmunotherapy based on inverse electron demand Diels-Alder reaction (IEDAA) between trans-cyclooctene (TCO) and tetrazine (Tz). Two tetrazine based chelators, DOTA-Tz and TCMC-Tz, were synthesized and compared for their radiolabeling efficiency with 212Pb, radiochemical stability and in-vivo pharmacokinetics...
November 12, 2017: Bioconjugate Chemistry
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