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in-vivo dosimetry

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https://www.readbyqxmd.com/read/27908159/a-preclinical-microbeam-facility-with-a-conventional-x-ray-tube
#1
Stefan Bartzsch, Craig Cummings, Stephan Eismann, Uwe Oelfke
PURPOSE: Microbeam radiation therapy is an innovative treatment approach in radiation therapy that uses arrays of a few tens of micrometer wide and a few hundreds of micrometer spaced planar x-ray beams as treatment fields. In preclinical studies these fields efficiently eradicated tumors while normal tissue could effectively be spared. However, development and clinical application of microbeam radiation therapy is impeded by a lack of suitable small scale sources. Until now, only large synchrotrons provide appropriate beam properties for the production of microbeams...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27904871/in-vivo-measurement-and-characterization-of-a-novel-formulation-of-177-lu-dota-octreotate
#2
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David Lh Chan, Alireza Aslani, Paul J Roach
OBJECTIVES: Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) (177)Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr(3))-octreotate with NCA (177)Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) (177)Lu imaging...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27895688/electromagnetic-tracking-for-treatment-verification-in-interstitial-brachytherapy
#3
REVIEW
Christoph Bert, Markus Kellermeier, Kari Tanderup
Electromagnetic tracking (EMT) is used in several medical fields to determine the position and orientation of dedicated sensors, e.g., attached to surgical tools. Recently, EMT has been introduced to brachytherapy for implant reconstruction and error detection. The manuscript briefly summarizes the main issues of EMT and error detection in brachytherapy. The potential and complementarity of EMT as treatment verification technology will be discussed in relation to in vivo dosimetry and imaging.
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27894688/dna-and-chromosomal-damage-in-medical-workers-exposed-to-anaesthetic-gases-assessed-by-the-lymphocyte-cytokinesis-block-micronucleus-cbmn-assay-a-critical-review
#4
REVIEW
Pavel Vodicka, Ludovit Musak, Giovanni Fiorito, Veronika Vymetalkova, Ludmila Vodickova, Alessio Naccarati
The lymphocyte cytokinesis-block micronucleus (CBMN) assay has been applied in hundreds of in vivo biomonitoring studies of humans exposed either environmentally or occupationally to genotoxic chemicals. However, there is an emerging need to re-evaluate the use of MN and other biomarkers within the lymphocyte CBMN cytome assay as quantitative indicators of exposure to main classes of chemical genotoxins. The main aim of the present report is to systematically review published studies investigating the use of the lymphocyte CBMN assay to determine DNA damage in subjects exposed to anaesthetic gases...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27890808/use-of-physiologically-based-kinetic-modeling-facilitated-reverse-dosimetry-of-in-vitro-toxicity-data-for-prediction-of-in-vivo-developmental-toxicity-of-tebuconazole-in-rats
#5
Hequn Li, Mengying Zhang, Jacques Vervoort, Ivonne M C M Rietjens, Bennard van Ravenzwaay, Jochem Louisse
Toxicological hazard and risk assessment largely rely on animal testing. For economic and ethical reasons, the development and validation of reliable alternative methods for these animal studies, such as in vitro assays, are urgently needed. In vitro concentration-response curves, however, need to be translated into in vivo dose-response curves for risk assessment purposes. In the present study, we translated in vitro concentration-response data of the antifungal compound tebuconazole, obtained in the ES-D3 cell differentiation assay, into predicted in vivo dose-response data for developmental toxicity using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry...
November 24, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27867173/evaluation-of-in-vivo-volumetric-dosimetry-for-prostate-cancer-using-electronic-portal-imaging-device
#6
Toshikazu Imae, Shigeharu Takenaka, Yuuichi Watanabe, Yukari Okano, Makoto Nedu, Shigeki Saegusa, Yukihiro Takeuchi, Keiichi Yano, Akihiro Haga, Kenshirou Shiraishi, Hideomi Yamashita, Keiichi Nakagawa
PURPOSE: Volumetric modulated arc therapy (VMAT) is capable of acquiring projection images using electronic portal imaging device (EPID). Commercial EPID-based dosimetry software, dosimetry check (DC), allows in vivo dosimetry using projection images. The purpose of this study was to evaluate in vivo dosimetry for prostate cancer using VMAT. METHOD: VMAT plans were generated for eight patients with prostate cancer using treatment planning system (TPS), and patient quality assurances (QAs) were carried out with phantom...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27842982/in-vivo-skin-dose-measurement-using-moskin-detectors-in-tangential-breast-radiotherapy
#7
W L Jong, N M Ung, J H D Wong, K H Ng, W Z Wan Ishak, R Abdul Malik, V C E Phua, D L Cutajar, P E Metcalfe, A B Rosenfeld, G F Ho
The purpose of this study is to measure patient skin dose in tangential breast radiotherapy. Treatment planning dose calculation algorithm such as Pencil Beam Convolution (PBC) and in vivo dosimetry techniques such as radiochromic film can be used to accurately monitor radiation doses at tissue depths, but they are inaccurate for skin dose measurement. A MOSFET-based (MOSkin) detector was used to measure skin dose in this study. Tangential breast radiotherapies ("bolus" and "no bolus") were simulated on an anthropomorphic phantom and the skin doses were measured...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27842981/effect-of-verification-imaging-on-in-vivo-dosimetry-results-using-gafchromic-ebt3-film
#8
Trent Aland, Rebecca Moylan, Tanya Kairn, Jamie Trapp
In this work, the apparent treatment dose that kV planar or CBCT imaging contributes to Gafchromic EBT3 film used for in vivo dosimetry, was investigated. Gafchromic EBT3 film pieces were attached to a variety of phantoms and irradiated using the linear accelerator's built-in kV imaging system, in both kV planar mode and CBCT mode. To evaluate the sensitivity of the film in the clinical scenario where dose contributions are received from both imaging and treatment, additional pieces of film were irradiated using base doses of 50cGy and then irradiated using selected kV planar and CBCT techniques...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27818715/optical-fibre-sensors-their-role-in-in-vivo-dosimetry-for-prostate-cancer-radiotherapy
#9
REVIEW
P Woulfe, F J Sullivan, S O'Keeffe
Review is made of dosimetric studies of current optical fibre technology in radiotherapy for therapeutic applications, focusing particularly on in vivo dosimetry for prostate radiotherapy. We present the various sensor designs along with the main advantages and disadvantages associated with this technology. Optical fibres are ideally placed for applications in radiotherapy dosimetry; due to their small size they are lightweight and immune to electromagnetic interferences. The small dimensions of optical fibres allows it to be easily guided within existing brachytherapy equipment; for example, within the seed implantation needle for direct tumour dose analysis, in the urinary catheter to monitor urethral dose, or within the biopsy needle holder of the transrectal ultrasound probe to monitor rectal wall dose...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/27815601/integrating-in-vitro-data-and-physiologically-based-kinetic-pbk-modelling-to-assess-the-in-vivo-potential-developmental-toxicity-of-a-series-of-phenols
#10
Marije Strikwold, Bert Spenkelink, Laura H J de Haan, Ruud A Woutersen, Ans Punt, Ivonne M C M Rietjens
Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use of in vitro toxicity outcomes in the safety assessment of chemicals. The aim of the present study was to translate in vitro embryotoxicity data for a series of phenols to in vivo developmental toxic potency values for the rat by physiologically based kinetic (PBK) modelling-based reverse dosimetry...
November 4, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27806603/a-depth-sensing-technique-on-3d-printed-compensator-for-total-body-irradiation-patient-measurement-and-treatment-planning
#11
Min-Young Lee, Bin Han, Cesare Jenkins, Lei Xing, Tae-Suk Suh
PURPOSE: The purpose of total body irradiation (TBI) techniques is to deliver a uniform radiation dose to the entire volume of a patient's body. Due to variations in the thickness of the patient, it is difficult to produce such a uniform dose distribution throughout the body. In many techniques, a compensator is used to adjust the dose delivered to various sections of the patient. The current study aims to develop and validate an innovative method of using depth-sensing cameras and 3D printing techniques for TBI treatment planning and compensator fabrication...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27805056/interaction-of-benzo-a-pyrene-diol-epoxide-isomers-with-human-serum-albumin-site-specific-characterisation-of-adducts-and-associated-kinetics
#12
Hitesh V Motwani, Emelie Westberg, Margareta Törnqvist
Carcinogenicity of benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)} involves DNA-modification by B[a]P diol epoxide (BPDE) metabolites. Adducts to serum albumin (SA) are not repaired, unlike DNA adducts, and therefore considered advantageous in assessment of in vivo dose of BPDEs. In the present work, kinetic experiments were performed in relation to the dose (i.e. concentration over time) of different BPDE isomers, where human SA (hSA) was incubated with respective BPDEs under physiological conditions...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27790075/practical-issues-regarding-angular-and-energy-response-in-in-vivo-intraoperative-electron-radiotherapy-dosimetry
#13
Juan López-Tarjuelo, Ana Bouché-Babiloni, Virginia Morillo-Macías, Agustín Santos-Serra, Carlos Ferrer-Albiach
AIM: To estimate angular response deviation of MOSFETs in the realm of intraoperative electron radiotherapy (IOERT), review their energy dependence, and propose unambiguous names for detector rotations. BACKGROUND: MOSFETs have been used in IOERT. Movement of the detector, namely rotations, can spoil results. MATERIALS AND METHODS: We propose yaw, pitch, and roll to name the three possible rotations in space, as these unequivocally name aircraft rotations...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27776176/evaluation-of-cd146-as-target-for-radioimmunotherapy-against-osteosarcoma
#14
Sara Westrøm, Tina B Bønsdorff, Nasir Abbas, Øyvind S Bruland, Thora J Jonasdottir, Gunhild M Mælandsmo, Roy H Larsen
BACKGROUND: Osteosarcoma is a rare form of cancer but with a substantial need for new active drugs. There is a particular need for targeted therapies to combat metastatic disease. One possible approach is to use an antibody drug conjugate or an antibody radionuclide conjugate to target the osteosarcoma metastases and circulating tumor cells. Herein we have evaluated a radiolabeled monoclonal antibody targeting CD146 both in vitro and in vivo. METHODS AND RESULTS: A murine monoclonal anti-CD146 IgG1 isotype antibody, named OI-3, was developed along with recombinant chimeric versions with human IgG1 or human IgG3 Fc sequences...
2016: PloS One
https://www.readbyqxmd.com/read/27768849/use-of-physiologically-based-kinetic-modeling-based-reverse-dosimetry-to-predict-in-vivo-toxicity-from-in-vitro-data
#15
Jochem Louisse, Karsten Beekmann, Ivonne Magdalena Catharina Maria Rietjens
The development of reliable non-animal based testing strategies, such as in vitro bioassays, is the holy grail in current human safety testing of chemicals. However, the use of in vitro toxicity data in risk assessment is not straightforward. One of the main issues is that concentration-response curves from in vitro models need to be converted to in vivo dose-response curves. These dose-response curves are needed in toxicological risk assessment to obtain a point of departure to determine safe exposure levels for humans...
October 21, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27765857/assessment-of-tryptophan-uptake-and-kinetics-using-1-2-18f-fluoroethyl-l-tryptophan-and-%C3%AE-11c-methyl-l-tryptophan-pet-imaging-in-mice-implanted-with-patient-derived-brain-tumor-xenografts
#16
Sharon K Michelhaugh, Otto Muzik, Anthony R Guastella, Neil V Klinger, Lisa A Polin, Hancheng Cai, Yanchun Xin, Thomas J Mangner, Shaohui Zhang, Csaba Juhasz, Sandeep Mittal
: Abnormal tryptophan metabolism via the kynurenine pathway (KP) is involved in the pathophysiology of a variety of human diseases including cancers. α-[(11)C]-methyl-L-tryptophan ((11)C-AMT) positron emission tomography (PET) imaging demonstrated increased tryptophan uptake and trapping in epileptic foci and brain tumors, but the short half-life of (11)C limits its widespread clinical application. Recent in vitro studies suggested that the novel radiotracer 1-(2-[(18)F]fluoroethyl)-L-tryptophan ((18)F-FETrp) may be useful to assess tryptophan metabolism via the KP...
October 20, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27754748/improved-pharmacokinetics-following-pegylation-and-dimerization-of-a-c-rgd-ach-k-conjugate-used-for-tumor-positron-emission-tomography-imaging
#17
Ji Woong Lee, Yong Jin Lee, Un Chol Shin, Suhng Wook Kim, Byung Il Kim, Kyo Chul Lee, Jung Young Kim, Ji-Ae Park
Improving the in vivo pharmacokinetics (PK) of positron emission tomography (PET) radiotracers is of critical importance to tumor diagnosis and therapy. In the case of peptide-based radiotracers, the modification and addition of a linker or spacer functional group often offer faster in vivo pharmacokinetic behavior. In this study, the authors introduced two new PEGlyated dimeric c(RGD-ACH-K) conjugates, in which an aminocyclohexane carboxylic acid (ACH) is inserted into the ring chain of the cyclic RGD peptides, with a common bifunctional chelator (DOTA or NOTA) used for labeling with radiometals (including (68)Ga and (64)Cu)...
October 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27748899/feasibility-of-imaging-of-epidermal-growth-factor-receptor-expression-with-zegfr-2377-affibody-molecule-labeled-with-99mtc-using-a-peptide-based-cysteine-containing-chelator
#18
Ken G Andersson, Maryam Oroujeni, Javad Garousi, Bogdan Mitran, Stefan Ståhl, Anna Orlova, John Löfblom, Vladimir Tolmachev
The epidermal growth factor receptor (EGFR) is overexpressed in a number of malignant tumors and is a molecular target for several specific anticancer antibodies and tyrosine kinase inhibitors. The overexpression of EGFR is a predictive biomarker for response to several therapy regimens. Radionuclide molecular imaging might enable detection of EGFR overexpression by a non-invasive procedure and could be used repeatedly. Affibody molecules are engineered scaffold proteins, which could be selected to have a high affinity and selectivity to predetermined targets...
October 5, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27675144/in-vivo-dosimetry-with-optically-stimulated-luminescent-dosimeters-for-conformal-and-intensity-modulated-radiation-therapy-a-2-year-multicenter-cohort-study
#19
A C Riegel, Y Chen, A Kapur, L Apicello, A Kuruvilla, A Rea, A Jamshidi, L Potters
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673962/in-vivo-dosimetry-with-2-methods-during-single-dose-intraoperative-electron-radiation-therapy-for-accelerated-partial-breast-irradiation
#20
A Petoukhova, I Rüssel, K van Wingerden, P Koper, A Marinelli, J van der Sijp, H Struikmans
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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