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https://www.readbyqxmd.com/read/29748892/updated-pharmacological-management-of-rheumatoid-arthritis-for-women-before-during-and-after-pregnancy-reflecting-recent-guidelines
#1
Kieran E Murray, Louise Moore, Celine O'Brien, Anne Clohessy, Caroline Brophy, Patricia Minnock, Oliver FitzGerald, Eamonn S Molloy, Anne-Barbara Mongey, Shane Higgins, Mary F Higgins, Fionnuala M Mc Auliffe, Douglas J Veale
BACKGROUND: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can cause significant disability, morbidity, mortality, and impaired fertility. It commonly affects women of childbearing age. Managing rheumatoid arthritis (RA) in the perinatal period poses challenges. There is concern about the teratogenic effects of many traditional disease-modifying anti-rheumatic drugs (DMARDs) and an ever-growing list of new therapeutic options with limited data in pregnancy and breastfeeding...
May 10, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29721500/antioxidant-enzyme-activities-and-secondary-metabolite-profiling-of-oil-palm-seedlings-treated-with-combination-of-npk-fertilizers-infected-with-ganoderma-boninense
#2
Mahbod Sahebi, Mohamed M Hanafi, Hasmah Mohidin, M Y Rafii, Parisa Azizi, Abu Seman Idris, A Fariz, Rambod Abiri, Sima Taheri, Mehdi Moradpoor
Oil palm ( Elaeis guineensis Jacq) is one of the major sources of edible oil. Reducing the effect of Ganoderma, main cause of basal stem rot (BSR) on oil palm, is the main propose of this study. Understanding the oil palm defense mechanism against Ganoderma infection through monitoring changes in the secondary metabolite compounds levels before/after infection by Ganoderma under different fertilizing treatment is required. Oil palm requires macro- and microelements for growth and yield. Manipulating the nutrient for oil palm is a method to control the disease...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29706792/distribution-and-depth-of-bottom-simulating-reflectors-in-the-nankai-subduction-margin
#3
Akihiro Ohde, Hironori Otsuka, Arata Kioka, Juichiro Ashi
Surface heat flow has been observed to be highly variable in the Nankai subduction margin. This study presents an investigation of local anomalies in surface heat flows on the undulating seafloor in the Nankai subduction margin. We estimate the heat flows from bottom-simulating reflectors (BSRs) marking the lower boundaries of the methane hydrate stability zone and evaluate topographic effects on heat flow via two-dimensional thermal modeling. BSRs have been used to estimate heat flows based on the known stability characteristics of methane hydrates under low-temperature and high-pressure conditions...
2018: Earth, Planets, and Space: EPS
https://www.readbyqxmd.com/read/29700132/draft-genome-sequence-of-the-phytopathogenic-fungus-ganoderma-boninense-the-causal-agent-of-basal-stem-rot-disease-on-oil-palm
#4
Condro Utomo, Zulfikar Achmad Tanjung, Redi Aditama, Rika Fithri Nurani Buana, Antonius Dony Madu Pratomo, Reno Tryono, Tony Liwang
Ganoderma boninense is the dominant fungal pathogen of basal stem rot (BSR) disease on Elaeis guineensis We sequenced the nuclear genome of mycelia using both Illumina and Pacific Biosciences platforms for assembly of scaffolds. The draft genome comprised 79.24 Mb, 495 scaffolds, and 26,226 predicted coding sequences.
April 26, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29691967/new-classification-of-maxillary-sinus-contours-and-its-relation-to-sinus-floor-elevation-surgery
#5
Lixuan Niu, Juan Wang, Huajie Yu, Lixin Qiu
BACKGROUND: It is complicated to select an appropriate sinus floor elevation and the procedure for sinus floor elevation lacks of consensus. Sinus contour plays an important role in choosing a surgery approach. But there are still no published articles revealing the influence of sinus contours to sinus floor elevation surgery. PURPOSE: We propose a new classification depending on sinus contours from cone-beam computed tomography (CBCT), analyze clinical characters of different types, and investigate the relationship between sinus contours and sinus floor elevation...
April 25, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29681896/new-insights-into-the-mechanisms-and-biological-roles-of-d-amino-acids-in-complex-eco-systems
#6
REVIEW
Alena Aliashkevich, Laura Alvarez, Felipe Cava
In the environment bacteria share their habitat with a great diversity of organisms, from microbes to humans, animals and plants. In these complex communities, the production of extracellular effectors is a common strategy to control the biodiversity by interfering with the growth and/or viability of nearby microbes. One of such effectors relies on the production and release of extracellular D-amino acids which regulate diverse cellular processes such as cell wall biogenesis, biofilm integrity, and spore germination...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29562683/screening-of-genes-related-to-early-and-late-flowering-in-tree-peony-based-on-bulked-segregant-rna-sequencing-and-verification-by-quantitative-real-time-pcr
#7
Xiaogai Hou, Qi Guo, Weiqiang Wei, Lili Guo, Dalong Guo, Lin Zhang
Tree peony ( Paeonia suffruticosa Andrews) is a perennial woody shrub bearing large and colorful flowers. However, the flowering period is short and relatively uniform, which to an important extent hinders the cultivation and exploitation of ornamental peonies. In this study, the segregation of an F₁ population derived from P. ostti 'Feng Dan' (an early-flowering cultivar) × P. suffruticosa 'Xin Riyuejin' (a late-flowering cultivar) was used to screen and analyze candidate genes associated with flowering period of the two parents...
March 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29491869/development-of-molecular-markers-linked-to-powdery-mildew-resistance-gene-pm4b-by-combining-snp-discovery-from-transcriptome-sequencing-data-with-bulked-segregant-analysis-bsr-seq-in-wheat
#8
Peipei Wu, Jingzhong Xie, Jinghuang Hu, Dan Qiu, Zhiyong Liu, Jingting Li, Miaomiao Li, Hongjun Zhang, Li Yang, Hongwei Liu, Yang Zhou, Zhongjun Zhang, Hongjie Li
Powdery mildew resistance gene Pm4b , originating from Triticum persicum , is effective against the prevalent Blumeria graminis f. sp. tritici ( Bgt ) isolates from certain regions of wheat production in China. The lack of tightly linked molecular markers with the target gene prevents the precise identification of Pm4b during the application of molecular marker-assisted selection (MAS). The strategy that combines the RNA-Seq technique and the bulked segregant analysis (BSR-Seq) was applied in an F2:3 mapping population (237 families) derived from a pair of isogenic lines VPM1/7∗ Bainong 3217 F4 (carrying Pm4b ) and Bainong 3217 to develop more closely linked molecular markers...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29488247/selective-measurement-of-1-h-1-h-scalar-couplings-from-crowded-chemical-shift-regions-combined-pure-shift-and-spin-echo-modulation-approach
#9
Veera Mohana Rao Kakita, Kanaka Mahalakshmi Jerripothula, Sahithya Phani Babu Vemulapalli, Jagadeesh Bharatam
JHH scalar couplings carry rich structural information and their measurements are fundamental in the 1 H NMR based elucidation of small and medium molecules, which, however, are hampered in the presence of large J-coupling network. Further, enhanced spectral resolution is often essential for precise determination of a specific set of 1 H-1 H J-couplings among the complex J-multiplets. In the light of the recent advancements in homodecoupling pure shift strategies, here, we report absorption mode, band-selective refocused pure shift spin-echo method, which helps in determining 1 H-1 H J-couplings from crowded spectral regions...
February 27, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29485029/construction-and-characterization-of-an-infectious-molecular-clone-of-novel-duck-reovirus
#10
Qiaomei Wu, Mingyang Ding, Chuanfeng Li, Guangqing Liu, Zongyan Chen
Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is currently an infectious agent for ducks. Studies on NDRV replication and pathogenesis have been hampered by the lack of an available reverse-genetics system. In this study, a plasmid-based reverse-genetics system that is free of helper viruses has been developed. In this system, 10 full-length gene segments of wild-type NDRV TH11 strain are transfected into BSR-T7/5 cells that express bacteriophage T7 RNA polymerase...
April 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29479875/clinical-utility-of-ordered-pathology-blood-smear-reviews-an-overused-resource
#11
Michelle E Kurt-Mangold, Caleb V Grieme, Matthew D Krasowski, Nancy S Rosenthal
BACKGROUND: Blood smear reviews by pathologists (BSR) are ordered frequently at our institution, take time to evaluate, and result in a written report. Minimal research has been done regarding the amount of novel data reported and its clinical utility. METHODS: Detailed chart review was performed on BSR orders from January 1, 2015 to March 31, 2015 to assess reasons for smear review, if results were mentioned in the chart, if laboratory-driven reviews were already performed, and if novel, clinically influential data was reported...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29477061/development-of-biochemical-sulfide-potential-bsp-test-for-sulfidogenic-biotechnology-application
#12
Lin Chen, To-Hung Tsui, George A Ekama, Hamish R Mackey, Tianwei Hao, Guanghao Chen
The determination of organics biodegradability and corresponding biodegradation kinetics provides valuable information on the optimal design and operation of anaerobic biotechnology especially for sulfidogenesis. This study proposes a deterministic method, i.e. a biochemical sulfide potential (BSP) test, and compares it to the conventional biochemical methane potential (BMP) test in terms of their ability to characterize sulfate-laden organic waste biodegradability. It demonstrated 1.48 times higher degradation of volatile suspended solids (VSS) and 2...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29432165/loss-of-function-of-a-rice-tpr-domain-rna-binding-protein-confers-broad-spectrum-disease-resistance
#13
Xiaogang Zhou, Haicheng Liao, Mawsheng Chern, Junjie Yin, Yufei Chen, Jianping Wang, Xiaobo Zhu, Zhixiong Chen, Can Yuan, Wen Zhao, Jing Wang, Weitao Li, Min He, Bingtian Ma, Jichun Wang, Peng Qin, Weilan Chen, Yuping Wang, Jiali Liu, Yangwen Qian, Wenming Wang, Xianjun Wu, Ping Li, Lihuang Zhu, Shigui Li, Pamela C Ronald, Xuewei Chen
Crops carrying broad-spectrum resistance loci provide an effective strategy for controlling infectious disease because these loci typically confer resistance to diverse races of a pathogen or even multiple species of pathogens. Despite their importance, only a few crop broad-spectrum resistance loci have been reported. Here, we report the identification and characterization of the rice bsr-k1 (broad-spectrum resistance Kitaake-1) mutant, which confers broad-spectrum resistance against Magnaporthe oryzae and Xanthomonas oryzae pv oryzae with no major penalty on key agronomic traits...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29406604/allelic-variation-for-broad-spectrum-resistance-and-susceptibility-to-bacterial-pathogens-identified-in-a-rice-magic-population
#14
Ana M Bossa-Castro, Cheick Tekete, Chitra Raghavan, Emily E Delorean, Alexis Dereeper, Karim Dagno, Ousmane Koita, Gloria Mosquera, Hei Leung, Valérie Verdier, Jan E Leach
Quantitative trait loci (QTL) that confer broad-spectrum resistance (BSR), or resistance that is effective against multiple and diverse plant pathogens, have been elusive targets of crop breeding programmes. Multiparent advanced generation intercross (MAGIC) populations, with their diverse genetic composition and high levels of recombination, are potential resources for the identification of QTL for BSR. In this study, a rice MAGIC population was used to map QTL conferring BSR to two major rice diseases, bacterial leaf streak (BLS) and bacterial blight (BB), caused by Xanthomonas oryzae pathovars (pv...
February 6, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29405525/inhibition-and-kinetic-studies-of-cellulose-and-hemicellulose-degrading-enzymes-of-ganoderma-boninense-by-naturally-occurring-phenolic-compounds
#15
A Surendran, Y Siddiqui, N S Ali, S Manickam
AIM: Ganoderma sp, the causal pathogen of the basal stem rot (BSR) disease of oil palm, secretes extracellular hydrolytic enzymes. These play an important role in the pathogenesis of BSR by nourishing the pathogen through the digestion of cellulose and hemicellulose of the host tissue. Active suppression of hydrolytic enzymes secreted by Ganoderma boninense by various naturally occurring phenolic compounds and estimation of their efficacy on pathogen suppression is focused in this study...
February 5, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29370223/breeding-sex-ratio-and-population-size-of-loggerhead-turtles-from-southwestern-florida
#16
Jacob A Lasala, Colin R Hughes, Jeanette Wyneken
Species that display temperature-dependent sex determination are at risk as a result of increasing global temperatures. For marine turtles, high incubation temperatures can skew sex ratios towards females. There are concerns that temperature increases may result in highly female-biased offspring sex ratios, which would drive a future sex ratio skew. Studying the sex ratios of adults in the ocean is logistically very difficult because individuals are widely distributed and males are inaccessible because they remain in the ocean...
2018: PloS One
https://www.readbyqxmd.com/read/29326278/an-update-on-the-management-of-gout
#17
(no author information available yet)
Gout is the most common form of inflammatory arthritis and its incidence in the UK has steadily increased from 1.5% in 1997 to 2.5% in 2012.1,2 It is characterised by deposition of monosodium urate crystals in joints and tissues and usually presents with intermittent painful attacks followed by long periods of remission.3 It has been suggested that the management of gout in the UK remains suboptimal.1 In 2004, we concluded that there was a woeful lack of evidence to guide treatment or prophylaxis for gout, particularly with regard to choice of drug or doses...
January 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29317305/investigation-of-putative-invasion-determinants-of-actinobacillus-species-using-comparative-genomics
#18
Adina R Bujold, Andrew E Shure, Rui Liu, Andrew M Kropinski, Janet I MacInnes
Actinobacillus spp. are Gram-negative bacteria associated with mucosal membranes. While some are commensals, others can cause important human and animal diseases. A. pleuropneumoniae causes severe fibrinous hemorrhagic pneumonia in swine but not systemic disease whereas other species invade resulting in septicemia and death. To understand the invasive phenotype of Actinobacillus spp., complete genomes of eight isolates were obtained and pseudogenomes of five isolates were assembled and annotated. Phylogenetically, A...
January 6, 2018: Genomics
https://www.readbyqxmd.com/read/29281878/synthesis-of-hexaconazole-zinc-aluminum-layered-double-hydroxide-nanocomposite-fungicide-nanodelivery-system-for-controlling-ganoderma-disease-in-oil-palm
#19
Isshadiba F Mustafa, Mohd Zobir Hussein, Bullo Saifullah, Abu Seman Idris, Nur Hailini Z Hilmi, Sharida Fakurazi
A fungicide, hexaconazole was successfully intercalated into the intergalleries of zinc/aluminum-layered double hydroxide (ZALDH) using the ion-exchange method. Due to the intercalation of hexaconazole, the basal spacing of the ZALDH was increased from 8.7 Å in ZALDH to 29.4 Å in hexaconazole-intercalated ZALDH (HZALDH). The intercalation of hexaconazole into the interlayer of the nanocomposite was confirmed using the Fourier-transform infrared (FTIR) study. This supramolecular chemistry intercalation process enhanced the thermal stability of the hexaconazole moiety...
January 31, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29142128/interaction-between-a-unique-minor-protein-and-a-major-capsid-protein-of-bluetongue-virus-controls-virus-infectivity
#20
Eiko Matsuo, Kiyoshi Yamazaki, Hiroki Tsuruta, Polly Roy
Among the Reoviridae family of double-stranded RNA viruses, only members of the Orbivirus genus possess a unique structural protein, termed VP6, within their particles. Bluetongue virus (BTV), an important livestock pathogen, is the prototype Orbivirus The BTV VP6 is an ATP-dependent RNA helicase and it is indispensable for virus replication. In this report, we investigated how VP6 might be recruited to the virus capsid and whether the BTV structural protein VP3, which forms the internal layer of the virus capsid core, is involved in VP6 recruitment...
November 15, 2017: Journal of Virology
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