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Mingming Wang, Wei Zhan
The grand scale, ultimate efficiency, and sustainability of natural photosynthesis have inspired generations of researchers in biomimetic light energy utilization. As an essential and ubiquitous component in all photosynthetic machinery, lipids and their assemblies have long been recognized as powerful molecular scaffolds in building artificial photosynthetic systems. Model lipid bilayers, such as black lipid membranes and liposomes (vesicles), have been extensively used to host natural as well as synthetic photo- and redox-active species, thereby enabling key photosynthetic processes, such as energy transfer and photoinduced electron transfer, to be examined in well-defined, natural-like membrane settings...
October 19, 2016: Accounts of Chemical Research
Fengyang Xu, Jie Liu, Jian Tian, Lingfeng Gao, Xiaju Cheng, Yue Pan, Ziling Sun, Xinming Li
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule firstly tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e...
October 19, 2016: ACS Applied Materials & Interfaces
Jamal Mohammadi Ayenehdeh, Bahareh Niknam, Seyed Mahmoud Hashemi, Hossein Rahavi, Nima Rezaei, Masoud Soleimani, Nader Tajik
BACKGROUND: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functional islets and transplantation are crucial. METHODS: The present study has introduced an experimental model that overcomes some critical issues in islet transplantation, including in situ pancreas perfusion by digestive enzymes through common bile duct...
October 18, 2016: Iranian Biomedical Journal
Carla Ferreri, Bernard T Golding, Ullrich Jahn, Jean-Luc Ravanat
The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for four years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defences, WG4 - Bio-inspired synthetic strategies. International collaborations have been established among the participating 80 research groups with brilliant interdisciplinary achievements. Free radical research with a biomimetic approach has been realized in the COST Action and are summarized in this overview by the four WG leaders...
October 17, 2016: Free Radical Research
Morteza Amjadi, Metin Sitti
There is an increasing demand for soft actuators because of their importance in soft robotics, artificial muscles, biomimetic devices, and beyond. However, the development of soft actuators capable of low-voltage operation, powerful actuation, and programmable shape-changing is still challenging. In this work, we propose programmable bilayer actuators that operate based on the large hygroscopic contraction of the copy paper and simultaneously large thermal expansion of the polypropylene film upon increasing the temperature...
October 16, 2016: ACS Nano
Hwan D Kim, Hae Lin Jang, Hyo-Yong Ahn, Hye Kyoung Lee, Jungha Park, Eun-Seo Lee, Eunjee A Lee, Yong-Hoon Jeong, Do-Gyoon Kim, Ki Tae Nam, Nathaniel S Hwang
Bone remodeling process relies on complex signaling pathway between osteoblasts and osteoclasts and control mechanisms to achieve homeostasis of their growth and differentiation. Despite previous achievements in understanding complicated signaling pathways between cells and bone extracellular matrices during bone remodeling process, a role of local ionic concentration remains to be elucidated. Here, we demonstrate that synthetic whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) nanoparticles can recapitulate early-stage of bone regeneration through stimulating osteogenic differentiation, prohibiting osteoclastic activity, and transforming into mechanically enhanced hydroxyapatite (HAP)-neo bone tissues by continuous supply of PO4(3-) and Mg(2+) under physiological conditions...
October 11, 2016: Biomaterials
Tracy N Clevenger, Gabriel Luna, Daniel Boctor, Steven K Fisher, Dennis O Clegg
One of the most common regenerative therapies is autologous fat grafting, which frequently suffers from unexpected volume loss. One approach is to deliver adipose stem cells encapsulated in the engineered hydrogels supportive of cell survival, differentiation, and integration after transplant. We describe an encapsulating, biomimetic poly(ethylene)-glycol hydrogel, with embedded peptides for attachment and biodegradation. Poly(ethylene)-glycol hydrogels containing an Arg-Gly-Asp attachment sequence and a matrix metalloprotease 3/10 cleavage site supported adipose stem cell survival and showed remodeling initiated by adipogenic differentiation...
January 2016: Journal of Tissue Engineering
Emilio Brunetti, Steven Moerkerke, Johan Wouters, Kristin Bartik, Ivan Jabin
The development of chemosensors that can selectively detect phosphatidylcholines (PCs) in biological samples is of medical relevance considering the importance of these phospholipids in cell growth and survival. Their selective sensing over phosphatidylethanolamines (PEs) is however a challenging task. We report here on the chemosensing capacities of calix[6]tris-pyrenylurea 1, which is able to selectively interact with phosphatidylcholine-type lipids in organic media. Host 1 also binds them in a biphasic chloroform/water solution, opening the way to the design of selective chemosensors for these lipids in biological media...
October 12, 2016: Organic & Biomolecular Chemistry
Klaus Speck, Raphael Wildermuth, Thomas Magauer
The cationic cyclization of polyenes constitutes a powerful and elegant transformation, which has been utilized by nature's biosynthetic machinery for the construction of complex polycyclic terpenoids. Previous studies by chemists to mimic this cyclization in the laboratory were limited to different modes of activation using biosynthetic-like precursors, which accommodate only simple methyl-derived substituents. Here we describe the development of an unprecedented and highly efficient polyene cyclization of an aryl enol ether containing substrate...
October 12, 2016: Angewandte Chemie
Pascal Magne, Luís Henrique Schlichting
Currently, no dental material can exactly match the unique properties of dentin and enamel. Recently, a revolutionary approach was introduced in which a real tooth was utilized in combination with computer-aided design/computer-aided manufacturing (CAD/CAM) technology to obtain a natural CAD/CAM restoration. After 4 years of clinical service, the case was reevaluated and revealed an optimal condition of the biomimetic restoration.
2016: International Journal of Esthetic Dentistry
Lukmaan A Bawazer, Ciara S McNally, Christopher J Empson, William J Marchant, Tim P Comyn, Xize Niu, Soongwon Cho, Michael J McPherson, Bernard P Binks, Andrew deMello, Fiona C Meldrum
Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach uses a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated...
October 2016: Science Advances
Chun-Chieh Huang, Raghuvaran Narayanan, Satish Alapati, Sriram Ravindran
Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use of exosomes as biomimetic tools to induce stem cell differentiation. Working on the hypothesis that cell-type specific exosomes can trigger lineage-specific differentiation of stem cells, we have evaluated the potential of exosomes derived from dental pulp cells cultured on under growth and odontogenic differentiation conditions to induce odontogenic differentiation of naïve human dental pulp stem cells (DPSCs) and human bone marrow derived stromal cells (HMSCs) in vitro and in vivo...
September 30, 2016: Biomaterials
Brian Helmuth, Francis Choi, Allison Matzelle, Jessica L Torossian, Scott L Morello, K A S Mislan, Lauren Yamane, Denise Strickland, P Lauren Szathmary, Sarah E Gilman, Alyson Tockstein, Thomas J Hilbish, Michael T Burrows, Anne Marie Power, Elizabeth Gosling, Nova Mieszkowska, Christopher D G Harley, Michael Nishizaki, Emily Carrington, Bruce Menge, Laura Petes, Melissa M Foley, Angela Johnson, Megan Poole, Mae M Noble, Erin L Richmond, Matt Robart, Jonathan Robinson, Jerod Sapp, Jackie Sones, Bernardo R Broitman, Mark W Denny, Katharine J Mach, Luke P Miller, Michael O'Donnell, Philip Ross, Gretchen E Hofmann, Mackenzie Zippay, Carol Blanchette, J A Macfarlan, Eugenio Carpizo-Ituarte, Benjamin Ruttenberg, Carlos E Peña Mejía, Christopher D McQuaid, Justin Lathlean, Cristián J Monaco, Katy R Nicastro, Gerardo Zardi
At a proximal level, the physiological impacts of global climate change on ectothermic organisms are manifest as changes in body temperatures. Especially for plants and animals exposed to direct solar radiation, body temperatures can be substantially different from air temperatures. We deployed biomimetic sensors that approximate the thermal characteristics of intertidal mussels at 71 sites worldwide, from 1998-present. Loggers recorded temperatures at 10-30 min intervals nearly continuously at multiple intertidal elevations...
October 11, 2016: Scientific Data
Juan Liu, Viktoriia Y Postupalenko, Samuel Loercher, Dalin Wu, Mohamed Chami, Wolfgang Meier, Cornelia G Palivan
Self-organization of nano-components was mainly focused on solid nanoparticles, quantum dots or liposomes to generate complex architectures with specific properties, but intrinsically limited or not developed enough, to mimic sophisticated structures with biological functions in cells. Here, we present a biomimetic strategy to self-organize synthetic nano-compartments (polymersomes) into clusters with controlled properties and topology by exploiting DNA hybridization to interconnect polymersomes. Molecular- and external factors affecting the self-organization served to design clusters mimicking the connection of natural organelles: fine tune of the distance between tethered polymersomes, different topologies, no fusion of clustered polymersomes and no aggregation...
October 11, 2016: Nano Letters
Maren Jannasch, Tobias Weigel, Lisa Engelhardt, Judith Wiezoreck, Sabine Gaetzner, Heike Walles, Tobias Schmitz, Jan Hansmann
Surgical implantation of a biomaterial triggers foreign-body-induced fibrous encapsulation. Two major mechanisms of this complex physiological process are (I) chemotaxis of fibroblasts from surrounding tissue to the implant region, followed by (II) tissue remodeling. As an alternative to animal studies, we here propose anprocess-aligned in vitrotest platform to investigate the material dependency of fibroblast chemotaxis and tissue remodeling, mediated by material-resident macrophages. Embedded in a biomimetic three-dimensional collagen hydrogel, chemotaxis of fibroblasts in direction of macrophage-material-incubated cell culture supernatant was analysed by live-cell imaging...
October 11, 2016: ALTEX
Ying Hao, Aidan B Zerdoum, Alexander J Stuffer, Ayyappan K Rajasekaran, Xinqiao Jia
Towards the goal of establishing physiologically relevant in vitro tumor models, we synthesized and characterized a biomimetic hydrogel using thiolated hyaluronic acid (HA-SH) and an acrylated copolymer carrying multiple copies of cell adhesive peptide (PolyRGD-AC). PolyRGD-AC was derived from a random copolymer of tert-butyl methacrylate (tBMA) and oligomeric (ethylene glycol) methacrylate (OEGMA), synthesized via atom transfer radical polymerization (ATRP). Acid hydrolysis of tert-butyl moieties revealed the carboxylates, through which acrylate groups were installed...
October 10, 2016: Biomacromolecules
Catarina Guise, Margarida M Fernandes, Sudhir Pathak, Walter Schneider, Raul Fangueiro
Current brain imaging methods largely fail to provide detailed information about the location and severity of axonal injuries, and do not anticipate recovery of the patients with traumatic brain injury. High-Definition Fiber Tractography appears as a novel imaging modality based on water motion in the brain that allows for direct visualization and quantification of the degree of axons damage, thus predicting the functional deficits due to traumatic axonal injury and loss of cortical projections. This neuroimaging modality still faces major challenges because it lacks a "gold standard" for the technique validation and respective quality control...
October 10, 2016: ACS Applied Materials & Interfaces
Jiří Hostaš, David Sigwalt, Marina Šekutor, Haresh Ajani, Matúš Dubecký, Jan Řezáč, Peter Y Zavalij, Liping Cao, Christian Wohlschlager, Kata Mlinarić-Majerski, Lyle Isaacs, Robert Glaser, Pavel Hobza
A training set of eleven X-ray structures determined for biomimetic complexes between cucurbit[n]uril (CB[7 or 8]) hosts and adamantane-/diamantane ammonium/aminium guests were studied with DFT-D3 quantum mechanical computational methods to afford ΔGcalcd binding energies. A novel feature of this work is that the fidelity of the BLYP-D3/def2-TZVPP choice of DFT functional was proven by comparison with more accurate methods. For the first time, the CB[n]⋅guest complex binding energy subcomponents [for example, ΔEdispersion , ΔEelectrostatic , ΔGsolvation , binding entropy (-TΔS), and induced fit Edeformation(host) , Edeformation(guest) ] were calculated...
October 10, 2016: Chemistry: a European Journal
Yu Shrike Zhang, Farideh Davoudi, Philipp Walch, Amir Manbachi, Xuan Luo, Valeria Dell'Erba, Amir K Miri, Hassan Albadawi, Andrea Arneri, Xiaoyun Li, Xiaoying Wang, Mehmet Remzi Dokmeci, Ali Khademhosseini, Rahmi Oklu
Pathologic thrombosis kills more people than cancer and trauma combined; it is associated with significant disability and morbidity, and represents a major healthcare burden. Despite advancements in medical therapies and imaging, there is often incomplete resolution of the thrombus. The residual thrombus can undergo fibrotic changes over time through infiltration of fibroblasts from the surrounding tissues and eventually transform into a permanent clot often associated with post-thrombotic syndrome. In order to understand the importance of cellular interactions and the impact of potential therapeutics to treat thrombosis, an in vitro platform using human cells and blood components would be beneficial...
October 18, 2016: Lab on a Chip
José A F de Oliveira, Marcos P da Silva, Bernardo de Souza, Tiago P Camargo, Bruno Szpoganicz, Ademir Neves, Adailton J Bortoluzzi
We describe herein the catecholase-like catalytic activity and dopamine polymerization by using a dinuclear [LCu(II)(μ-OH)2Cu(II)](ClO4)2 (1) complex where L is the dinucleating triazine-based ligand 6-chloro-N(2),N(2),N(4),N(4)-tetrakis(pyridin-2-ylmethyl)-1,3,5-triazine-2,4-diamine. The kinetic parameters (kcat = 0.318 s(-1), KM = 1.6 × 10(-3) mol L(-1), and kcat/KM = 198.8 L s(-1) mol(-1)), mechanistic insights into the oxidation of 3,5-di-tert-butyl catechol and early characterization of poly(dopamine) are presented...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
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