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Fatty acid placenta

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https://www.readbyqxmd.com/read/29772225/maternal-one-carbon-metabolism-through-increased-oxidative-stress-and-disturbed-angiogenesis-can-influence-placental-apoptosis-in-preeclampsia
#1
REVIEW
Vaishali V Kasture, Deepali P Sundrani, Sadhana R Joshi
Adequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12 ) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women with preeclampsia. Homocysteine is known to be involved in the formation of free radicals leading to increased oxidative stress...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29701266/sex-specific-alterations-in-serology-and-the-expression-of-liver-fatp4-protein-in-offspring-exposed-to-high-fat-diet-during-pregnancy-and-or-lactation
#2
Mingqiu Zhao, Yi Li, Huihui Yao, Lihua Dou, Shuya Zhang, Qihong Zhao, Li Li
Changes in dietary composition will have a significant impact on the nutritional status of the mother and the offspring. To examine the relevant hormone level changes during lactation and the expression of fatty acid transporters in the placenta and liver under the condition of a high-fat (HF) diet, we established HF animal models and conducted a cross-fostering program to mimic the shift in diet. On gestation day (GD)18, the weight of placenta in the HF group was significantly higher than that in the control group (p < 0...
March 2018: Lipids
https://www.readbyqxmd.com/read/29684673/exercise-as-a-therapeutic-intervention-to-optimize-fetal-weight
#3
REVIEW
Laura M Reyes, Margie H Davenport
The Developmental Origins of Health and Disease suggest the in utero environment programs offspring obesity and cardiovascular disease. Therefore, there is a need to implement safe therapeutic interventions that do not involve the intake of medications or biological products during pregnancy that can improve maternal and fetal health. Prenatal exercise is established to promote maternal and fetal health. It is generally recommended that women accumulate at least 150 min per week of moderate-intensity exercise...
April 22, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29679625/nutrition-therapy-within-and-beyond-gestational-diabetes
#4
REVIEW
Teri L Hernandez, Archana Mande, Linda A Barbour
With the global rising prevalence of gestational diabetes (GDM), an adaptable, economical approach to nutrition therapy that effectively controls maternal glycemia while promoting normal fetal growth will have far-reaching implications. The conventional focus has been to rigidly limit all types of carbohydrate. While controlling glucose, this approach fosters maternal anxiety and is a primary barrier to adherence. Many mothers substitute fat for carbohydrate, which may unintentionally enhance lipolysis, promote elevated free fatty acids (FFA), and worsen maternal insulin resistance (IR)...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29665425/omega-3-polyunsaturated-fatty-acids-promotes-angiogenesis-in-placenta-derived-mesenchymal-stromal-cells
#5
Suja Ann Mathew, Ramesh Bhonde
Enhancement of angiogenesis is solicited in wound repair and regeneration. Mesenchymal stromal cells derived from the placenta (P-MSCs) have an inherent angiogenic potential. Polyunsaturated fatty acids (PUFAs) in turn, specifically the omega-3 (N-3) are essential for growth and development. They are also recommended as dietary supplements during pregnancy. We therefore hypothesized that addition of N-3 PUFAs in P-MSC culture media may enhance their angiogenic potential. Hence we treated P-MSCs with omega-3 (N-3) fatty acids -Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) at different concentrations and tested their angiogenic potential...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29626981/placental-lipoprotein-lipase-activity-is-positively-associated-with-newborn-adiposity
#6
Margaret J R Heerwagen, Diane L Gumina, Teri L Hernandez, Rachael E Van Pelt, Anita W Kramer, Rachel C Janssen, Dalan R Jensen, Theresa L Powell, Jacob E Friedman, Virginia D Winn, Linda A Barbour
INTRODUCTION: Recent data suggest that in addition to glucose, fetal growth is related to maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids (FFA) and transported across the placenta, but regulation is uncertain. Placental lipoprotein lipase (pLPL) hydrolyzes TG, both dietary chylomicron TG (CM-TG) and very-low density lipoprotein TG (VLDL-TG), to FFA. This may promote fetal fat accretion by increasing the available FFA pool for placental uptake...
April 2018: Placenta
https://www.readbyqxmd.com/read/29626980/placental-function-and-structure-at-term-is-altered-in-broodmares-fed-with-cereals-from-mid-gestation
#7
M Robles, P Peugnet, C Dubois, F Piumi, L Jouneau, O Bouchez, M C Aubrière, M Dahirel, J Aioun, L Wimel, A Couturier-Tarrade, P Chavatte-Palmer
INTRODUCTION: Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at term in mares fed with or without cereals concentrates. MATERIAL AND METHODS: From 7 months of gestation, 22 multiparous mares were fed forage only (group F (n = 12)) or received forage and cracked barley (group B (n = 10)) until foaling...
April 2018: Placenta
https://www.readbyqxmd.com/read/29609233/-regulation-of-pravastatin-on-long-chain-fatty-acid-oxidative-enzyme-in-pre-eclampsia-like-mouse-model
#8
J Huai, Z Yang, Y H Yi, G J Wang, Q Q Xiang
Objective: To investigate the modulation of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) expression by pravastatin in pre-eclampsia-like mouse model. Methods: C57BL/6J mice were randomly injected with N-nitro-L-arginine methyl ester (L-NAME) as pre-eclampsia-like model group (PE) or saline as normal pregnancy control group (Con) respectively, from gestational the 7th to 18th day. For each group, pravastatin (PE+Pra, Con+Pra group) or saline (PE+N, Con+N Group) was given from the 8th to 18th day of gestation, respectively...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29588451/identification-of-the-functional-pathways-altered-by-placental-cell-exposure-to-high-glucose-lessons-from-the-transcript-and-metabolite-interactome
#9
C H Hulme, A Stevens, W Dunn, A E P Heazell, K Hollywood, P Begley, M Westwood, J E Myers
The specific consequences of hyperglycaemia on placental metabolism and function are incompletely understood but likely contribute to poor pregnancy outcomes associated with diabetes mellitus (DM). This study aimed to identify the functional biochemical pathways perturbed by placental exposure to high glucose levels through integrative analysis of the trophoblast transcriptome and metabolome. The human trophoblast cell line, BeWo, was cultured in 5 or 25 mM glucose, as a model of the placenta in DM. Transcriptomic analysis using microarrays, demonstrated 5632 differentially expressed gene transcripts (≥± 1...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29580983/a-comparison-of-ergosterol-and-plfa-methods-for-monitoring-the-growth-of-ligninolytic-fungi-during-wheat-straw-solid-state-cultivation
#10
Irnia Nurika, Daniel C Eastwood, Guy C Barker
Ergosterol, total phospholipid fatty acid (PLFA) and linoleic acid (18:2n-6) have all been used to determine fungal growth. This paper compares these methods to assess the growth of four different saprotrophic fungal species during solid state cultivation using a wheat straw substrate that have not been compared or measured previously. Ergosterol production appeared to track the mycelia growth well but its production differed considerably between fungi. This means that a specific conversion factor needs to be determined and applied for any given fungus...
March 23, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29518709/metabolic-predictors-of-peri-partum-diseases-and-their-association-with-parity-in-dairy-cows
#11
Gretel Ruprechter, Maria de Lourdes Adrien, Alejandro Larriestra, Otavio Meotti, Chester Batista, Ana Meikle, Mirela Noro
The predictive values of plasma non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), cholesterol, albumin and calcium to predict risk of peripartum diseases in primiparous (PP) and multiparous (MP) Holstein cows was investigated. Besides it was assessed if the health status interacted with parity on body condition score and metabolic profiles during the transition period. Dairy cows (126 PP and 182 MP) from a commercial dairy free stall herd (loose-housing system) were weekly body condition scored and tail bled for metabolites determination from -3 to +4 weeks relative to calving...
February 19, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29463583/alterations-in-placental-long-chain-polyunsaturated-fatty-acid-metabolism-in-human-intrauterine-growth-restriction
#12
Stephanie Skuby Chassen, Veronique Ferchaud-Roucher, Madhulika B Gupta, Thomas Jansson, Theresa L Powell
Fatty acids (FA) are critical for fetal brain development and are transferred across the placenta by membrane-bound FA transport proteins (FATP), translocases (FAT/CD36), and cytosolic binding proteins (FABP). The cytosolic protein perilipin-2 aids in neutral lipid storage within lipid droplets. Decreased placental nutrient transport is believed to contribute to intrauterine growth restriction (IUGR); however, IUGR placental lipid transport and metabolism are poorly understood. We hypothesized that protein expression of FATPs, FABPs, and perilipin-2 in human placenta is decreased and placental lipid content and incorporation into lipid classes are reduced in IUGR...
March 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29462922/differential-long-chain-polyunsaturated-fatty-acids-status-and-placental-transport-in-adolescent-pregnancies
#13
Fernanda Carrilho Pinto da Fonseca, Daniela de Barros Mucci, Renata Pereira Assumpção, Henrique Marcondes, Fátima Lúcia de Carvalho Sardinha, Simone Vargas Silva, Marta Citelli, Maria das Graças Tavares do Carmo
Adolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expression of key genes involved in FA uptake, transport and metabolism in the placenta of fifteen adolescents and fifteen adults. FA were quantified by gas-liquid chromatography. Placental expression of FA transporters was assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and peroxisome proliferator-activated receptor gamma (PPARγ) was quantified by Western Blot...
February 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29451152/different-effects-of-pravastatin-on-preeclampsia-like-symptoms-in-different-mouse-models
#14
Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang
Background: Pravastatin (Pra) exerts protective effects on preeclampsia. Preeclampsia is a multifactorial and pathogenic pathway syndrome. The present study compared the effects of Pra on clinical manifestations of preeclampsia in different pathogenic pathways. Methods: Two different preeclampsia-like mouse models used in this study were generated with Nω-nitro-L-arginine methyl ester (L-NAME) and used lipopolysaccharide (LPS) from day 7 of gestation, respectively...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29385477/excessive-backfat-of-sows-at-109-d-of-gestation-induces-lipotoxic-placental-environment-and-is-associated-with-declining-reproductive-performance
#15
Yuanfei Zhou, Tao Xu, Anle Cai, Yinghui Wu, Hongkui Wei, Siwen Jiang, Jian Peng
This study investigated the influence of sow backfat thickness at 109 d of gestation on sow and piglet performance. Data from 846 farrowing multiparous Yorkshire sows with parity from 3 to 5 were collected from a pig breeding farm. Sows were divided into six groups based on backfat thickness (≤16, 17-18, 19-20, 21-22, 23-24, and ≥25 mm) at 109 d of gestation. The evaluation of reproductive performance included the litter size, litter weight at birth and at weaning of 21 d, weight of placenta at parturition, placental efficiency, and sow daily feed intake of lactation...
February 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29367982/association-of-fatty-acids-and-lipids-metabolism-in-placenta-with-early-spontaneous-pregnancy-loss-in-chinese-women
#16
Kelei Li, Xiaotian Zhang, Gong Chen, Lijun Pei, Hailong Xiao, Jiajing Jiang, Jiaomei Li, Xiaoying Zheng, Duo Li
The aim of the present study was to evaluate the association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss (ESPL) in Chinese women. Seventy women with ESPL and 29 healthy pregnant women who asked for legal induced abortion were included in the case and control groups, respectively. The gestational age of the subject foetuses in both the case and control groups ranged from 4 to 10 weeks. The total fatty acids composition in the decidual and villous tissues was detected by gas-liquid chromatography using a standard method...
February 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29361796/role-of-3-hydroxy-fatty-acid-induced-hepatic-lipotoxicity-in-acute-fatty-liver-of-pregnancy
#17
REVIEW
Sathish Kumar Natarajan, Jamal A Ibdah
Acute fatty liver of pregnancy (AFLP), a catastrophic illness for both the mother and the unborn offspring, develops in the last trimester of pregnancy with significant maternal and perinatal mortality. AFLP is also recognized as an obstetric and medical emergency. Maternal AFLP is highly associated with a fetal homozygous mutation (1528G>C) in the gene that encodes for mitochondrial long-chain hydroxy acyl-CoA dehydrogenase (LCHAD). The mutation in LCHAD results in the accumulation of 3-hydroxy fatty acids, such as 3-hydroxy myristic acid, 3-hydroxy palmitic acid and 3-hydroxy dicarboxylic acid in the placenta, which are then shunted to the maternal circulation leading to the development of acute liver injury observed in patients with AFLP...
January 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29351577/effects-of-excess-thromboxane-a2-on-placental-development-and-nutrient-transporters-in-a-mus-musculus-model-of-fetal-growth-restriction
#18
Karen J Gibbins, Katherine N Gibson-Corley, Ashley S Brown, Matthew Wieben, Richard C Law, Camille M Fung
Hypertensive disease of pregnancy (HDP) with placental insufficiency is the most common cause of fetal growth restriction (FGR) in the developed world. Despite the known negative consequences of HDP both to the mother and fetus, little is known about the longitudinal placental changes that occur as HDP progresses in pregnancy. This is because longitudinal sampling of human placentae during each gestation is impossible. Therefore, using a mouse model of thromboxane A2-analog infusion to mimic human HDP in the last trimester, we calculated placental efficiencies based on fetal and placental weights, quantified spongiotrophoblast and labyrinth thicknesses and vascular density within these layers, examined whether hypoxia signaling pathway involving vascular endothelial growth factor A (VEGFA) and its receptors (VEGFR1, VEGFR2) and matrix metalloproteinases (MMPs) contributed to vascular change, and examined nutrient transporter abundance including glucose transporters 1 and 3 (GLUT1, GLUT3), neutral amino acid transporters 1, 2, and 4 (SNAT1, SNAT2, and SNAT4), fatty acid transporters 2 and 4 (FATP2, FATP4) and fatty acid translocase (CD36) from embryonic day 15...
January 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29316087/study-on-the-correlation-between-adipocyte-fatty-acid-binding-protein-glucolipid-metabolism-and-pre-eclampsia
#19
Yan-Ping Lin, Cai-Lin Xu, Kui-Sheng Lin, Hai-Bin Gu, Lei Chen, Ying Wang, Bao-Chuan Weng, Hai-Qing Huang, Ya-Ping Li, Yu-Liang Zou, Zi-Shun Li
AIM: We aimed to explore the relation between the level of adipocyte fatty-acid binding protein (A-FABP) in the gestational period and related indices of glucolipid metabolism, and the possible mechanisms of occurrence and development of pre-eclampsia. METHODS: Seventy-six pre-eclampsia patients were enrolled and divided into the mild pre-eclampsia (n = 42) and severe pre-eclampsia (n = 34) groups. Forty-eight healthy pregnant women were selected as a control group...
April 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29277276/preliminary-metabolomics-analysis-of-placenta-in-maternal-obesity
#20
Claudia Fattuoni, Chiara Mandò, Francesco Palmas, Gaia Maria Anelli, Chiara Novielli, Estefanìa Parejo Laudicina, Valeria Maria Savasi, Luigi Barberini, Angelica Dessì, Roberta Pintus, Vassilios Fanos, Antonio Noto, Irene Cetin
INTRODUCTION: Metabolomics identifies phenotypical groups with specific metabolic profiles, being increasingly applied to several pregnancy conditions. This is the first preliminary study analyzing placental metabolomics in normal weight (NW) and obese (OB) pregnancies. METHODS: Twenty NW (18.5 ≤ BMI< 25 kg/m2 ) and eighteen OB (BMI≥ 30 kg/m2 ) pregnancies were studied. Placental biopsies were collected at elective caesarean section. Metabolites extraction method was optimized for hydrophilic and lipophilic phases, then analyzed with GC-MS...
January 2018: Placenta
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