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Fatty acid placenta

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https://www.readbyqxmd.com/read/27913585/the-influence-of-placental-metabolism-on-fatty-acid-transfer-to-the-fetus
#1
Simone Perazzolo, Birgit Hirschmugl, Christian Wadsack, Gernot Desoye, Rohan M Lewis, Bram G Sengers
The factors determining Fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modelling approach to explore placental transfer of non-esterified fatty acids and identify rate-determining processes. The isolated perfused human placenta was used to study the uptake and transfer of [(13)C]-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal (13)C-fatty acids taken up by the placenta was delivered to the fetal circulation...
December 2, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27871288/tissue-specific-expression-of-human-fatty-acid-oxidation-enzyme-genes-in-late-pregnancy
#2
Jose L Bartha, Fernando Bugatto, Álvaro Fernández-Deudero, Rosa Fernández-Macías, Germán Perdomo
BACKGROUND: Abnormal fatty acid oxidation (FAO) is associated with maternal and fetal complications during pregnancy. The contribution of maternal and fetal tissues to FAO capacity during late pregnancy is important to understand the pathophysiology of pregnancy-associated complications. The aim of this study was to determine the expression levels of mitochondrial FAO enzymes in maternal and fetal tissues during late normal pregnancy. METHODS: We have measured by Real-time PCR the levels of long- and medium -chain acyl-CoA dehydrogenase (LCHAD and MCAD), two acyl-CoA dehydrogenases that catalyze the initial step in the mitochondrial FAO spiral...
November 21, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27859593/placental-specific-overexpression-of-sflt-1-alters-trophoblast-differentiation-and-nutrient-transporter-expression-in-an-iugr-mouse-model
#3
E Kühnel, V Kleff, V Stojanovska, S Kaiser, R Waldschütz, F Herse, T Plösch, E Winterhager, A Gellhaus
Since it is known that placental overexpression of the human anti-angiogenic molecule sFlt-1, the main candidate in the progression of preeclampsia, lead to intrauterine growth restriction (IUGR) in mice by lentiviral transduction of mouse blastocysts, we hypothesize that sFlt-1 influence placental morphology and physiology resulting in fetal IUGR. We therefore examined the effect of sFlt-1 on placental morphology and physiology at embryonic day 18.5 with histologic and morphometric analyses, transcript analyses, immunoblotting, and methylation studies...
November 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27806659/maternal-high-fat-diet-deficient-in-vitamin-b12-influences-long-chain-polyunsaturated-fatty-acid-composition-in-rats
#4
Shruti Jawale, Anubha Pulwale, Sadhana Joshi, Anvita Kale
OBJECTIVE: In India, there is a rise in non-communicable diseases due to diets deficient in vitamin B12, low in docosahexanoic acid (DHA) and increased consumption of westernized diet. The present study aims to examine the effect of maternal high fat diet in absence of vitamin B12 on pregnancy outcome and tissue fatty acid composition in dams. METHODS: Pregnant Wistar rats were assigned to following diets: Control (C), High fat diet (HFD), High fat diet supplemented with omega-3 fatty acids (HFDO), 4) High fat diet deficient in vitamin B12 (HFBD), High fat deficient in vitamin B12 supplemented with omega-3 fatty acids (HFBDO)...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27793454/the-association-of-plasma-glucose-bhba-and-nefa-with-postpartum-uterine-diseases-fertility-and-milk-production-of-holstein-dairy-cows
#5
M L S Bicalho, E C Marques, R O Gilbert, R C Bicalho
The objective of this study was to investigate the association between the metabolic indicators such as nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), and glucose during the transition period and the development of uterine diseases. In total, 181 Holstein dairy cows were enrolled in the study. Plasma glucose, NEFA, and BHBA concentrations were measured at -50, -6, 3, 7, and 14 days relative to parturition. All cows enrolled in the study were evaluated for retained placenta (RP), metritis, and endometritis...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27780972/developmental-origins-of-nafld-a-womb-with-a-clue
#6
REVIEW
Stephanie R Wesolowski, Karim C El Kasmi, Karen R Jonscher, Jacob E Friedman
Changes in the maternal environment leading to an altered intrauterine milieu can result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease acceleration in childhood and later in life. Particularly worrisome is that the prevalence of NAFLD is rapidly increasing among children and adults, and is being diagnosed at increasingly younger ages, pointing towards an early-life origin. A wealth of evidence, in humans and non-human primates, suggests that maternal nutrition affects the placenta and fetal tissues, leading to persistent changes in hepatic metabolism, mitochondrial function, the intestinal microbiota, liver macrophage activation and susceptibility to NASH postnatally...
October 26, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27771292/ceramidases-roles-in-sphingolipid-metabolism-and-in-health-and-disease
#7
Nicolas Coant, Wataru Sakamoto, Cungui Mao, Yusuf A Hannun
Over the past three decades, extensive research has been able to determine the biologic functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) (Hannun, 1996; Hannun et al., 1986; Okazaki et al., 1989). These studies have managed to define the metabolism, regulation, and function of these bioactive sphingolipids. This emerging body of literature has also implicated bioactive sphingolipids, particularly S1P and ceramide, as key regulators of cellular homeostasis...
October 11, 2016: Advances in Biological Regulation
https://www.readbyqxmd.com/read/27720038/the-effect-of-n-3-lcpufa-supplementation-on-oxidative-stress-and-inflammation-in-the-placenta-and-maternal-plasma-during-pregnancy
#8
G E Leghi, B S Muhlhausler
Pregnancy represents a state of heightened oxidative stress and inflammation, and these processes are further increased in pregnancy complications. The quality of the maternal diet is directly associated with maternal health and wellbeing, pregnancy and fetal outcomes, as well as the risk of pregnancy complications. Long chain polyunsaturated fatty acids (LCPUFAs) have significant potential to modify placental and fetal lipid environments and thereby modulate health outcomes. The omega-3 (n-3) LCPUFA in particular have been shown to exhibit both antioxidant and anti-inflammatory properties, and have potential therapeutic applications in reducing oxidative damage and inflammation during pregnancy...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27697222/modulation-of-fabp4-hypomethylation-by-dnmt1-and-its-inverse-interaction-with-mir-148a-152-in-the-placenta-of-preeclamptic-rats-and-htr-8-cells
#9
Anning Yang, Huiping Zhang, Yue Sun, Yanhua Wang, Xiaoming Yang, Xiaoling Yang, Hui Zhang, Wei Guo, Guangrong Zhu, Jue Tian, Yuexia Jia, Yideng Jiang
Inflammation and dysregulated lipid metabolism are involved in the pathogenesis of preeclampsia, and fatty acid binding protein 4 (FABP4) is known to regulate both inflammation and lipid metabolism. In the present study, we elucidated the role of FABP4 using in vitro and in vivo models of preclampsia. We found increased expression of FABP4 in the placenta of preeclamptic rats, which was further confirmed in HTR-8 cells, an extravillous trophoblast cell line, treated with L-NAME. Overexpression of FABP4 in HTR-8 cells resulted in upregulated expression of pro-inflammatory cytokines IL-6 and TNF-α, and increased lipid accumulation, suggesting that FABP4 plays a role in preeclampsia...
October 2016: Placenta
https://www.readbyqxmd.com/read/27678102/variable-methylation-potential-in-preterm-placenta-implication-for-epigenetic-programming-of-the-offspring
#10
Vinita V Khot, Preeti Chavan-Gautam, Savita Mehendale, Sadhana R Joshi
Children born preterm are reported to be at increased risk of developing noncommunicable diseases in later life. Altered placental DNA methylation patterns are implicated in fetal programming of adult diseases. Our earlier animal studies focus on micronutrients (folic acid, vitamin B12) and long-chain polyunsaturated fatty acids (LCPUFAs) that interact in the 1 carbon cycle, thereby influencing methylation reactions. Our previous studies in women delivering preterm show altered plasma levels of micronutrients and lower plasma LCPUFA levels...
September 27, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27638261/better-postpartal-performance-in-dairy-cows-supplemented-with-rumen-protected-methionine-compared-with-choline-during-the-peripartal-period
#11
Z Zhou, M Vailati-Riboni, E Trevisi, J K Drackley, D N Luchini, J J Loor
The onset of lactation in dairy cows is characterized by high output of methylated compounds in milk when sources of methyl group are in short supply. Methionine and choline (CHOL) are key methyl donors and their availability during this time may be limiting for milk production, hepatic lipid metabolism, and immune function. Supplementing rumen-protected Met and CHOL may improve overall performance and health of transition cows. The objective of this study was to evaluate the effect of supplemental rumen-protected Met and CHOL on performance and health of transition cows...
September 13, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27623544/corrigendum-to-long-chain-polyunsaturated-fatty-acids-stimulate-cellular-fatty-acid-uptake-in-human-placental-choriocarcinoma-bewo-cells-placenta-2009-1037-1044
#12
G M Johnsen, M S Weedon-Fekjær, K A R Tobin, A C Staff, A K Duttaroy
No abstract text is available yet for this article.
September 9, 2016: Placenta
https://www.readbyqxmd.com/read/27592442/clinical-response-after-chitosan-microparticle-administration-and-preliminary-assessment-of-efficacy-in-preventing-metritis-in-lactating-dairy-cows
#13
R Daetz, F Cunha, J H Bittar, C A Risco, F Magalhaes, Y Maeda, J E P Santos, K C Jeong, R F Cooke, K N Galvão
The objectives were to evaluate the clinical response to intrauterine administration of chitosan microparticles (CM) and to assess efficacy for preventing metritis in dairy cows. Holstein cows (n = 104; 40 primiparous and 64 multiparous) at increased risk for metritis (cows that had abortion, dystocia, twins, stillbirth, or retained placenta) were randomly assigned to 1 of 2 treatments at 1 d in milk (DIM; 24 h postpartum): CM group (n = 52), daily intrauterine infusion of 8 g of CM dissolved in 40 mL of sterile water for 5 d; control (CON) group (n = 52), daily intrauterine infusion of 40 mL of sterile water for 5 d...
August 31, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27578106/placental-dha-and-mrna-levels-of-ppar%C3%AE-and-lxr%C3%AE-and-their-relationship-to-birth-weight
#14
Akshaya P Meher, Nisha Wadhwani, Karuna Randhir, Savita Mehendale, Girija Wagh, Sadhana R Joshi
BACKGROUND: A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP)...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27577579/objective-measures-of-prenatal-alcohol-exposure-a-systematic-review
#15
REVIEW
Cheryl McQuire, Shantini Paranjothy, Lisa Hurt, Mala Mann, Daniel Farewell, Alison Kemp
CONTEXT: Objective measurement of prenatal alcohol exposure (PAE) is essential for identifying children at risk for adverse outcomes, including fetal alcohol spectrum disorders. Biomarkers have been advocated for use in universal screening programs, but their validity has not been comprehensively evaluated. OBJECTIVE: To systematically review the validity of objective measures of PAE. DATA SOURCES: Thirteen electronic databases and supplementary sources were searched for studies published between January 1990 and October 2015...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27568210/the-endocannabinoid-anandamide-impairs-in-vitro-decidualization-of-human-cells
#16
M Almada, C Amaral, M Diniz-da-Costa, G Correia-da-Silva, N A Teixeira, B M Fonseca
Endocannabinoids (eCBs) are endogenous mediators that along with the cannabinoid receptors (CB1 and CB2), a membrane transporter and metabolic enzymes form the endocannabinoid system (ECS). Several eCBs have been discovered with emphasis on anandamide (AEA). They are involved in several biological processes such as energy balance, immune response and reproduction. Decidualization occurs during the secretory phase of human menstrual cycle, which involves proliferation and differentiation of endometrial stromal cells into decidual cells and is crucial for the establishment and progression of pregnancy...
October 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27555877/the-effects-of-prenatal-metformin-on-obesogenic-diet-induced-alterations-in-maternal-and-fetal-fatty-acid-metabolism
#17
Kemoy Harris, Neeraj Desai, Madhu Gupta, Xiangying Xue, Prodyot K Chatterjee, Burton Rochelson, Christine N Metz
BACKGROUND: Maternal obesity may program the fetus and increase the susceptibility of the offspring to adult diseases. Metformin crosses the placenta and has been associated with decreased inflammation and reversal of fatty liver in obese leptin-deficient mice. We investigated the effects of metformin on maternal and fetal lipid metabolism and hepatic inflammation using a rat model of diet-induced obesity during pregnancy. METHODS: Female Wistar rats (6-7 weeks old) were fed normal or high calorie diets for 5 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27470150/maternal-weight-gain-regulates-omega-3-fatty-acids-in-male-not-female-neonates-a-cross-sectional-study
#18
Perrie F O'Tierney-Ginn, Melanie Gillingham, Jessica Fowler, Elizabeth Brass, Nicole E Marshall, Kent L Thornburg
The fetus largely depends on maternal supply and placental transport for its source of long-chain polyunsaturated fatty acids (LCPUFAs), which are essential for proper neurological and cardiovascular development. Pregnancy complications such as diabetes reduces neonatal LCPUFA supply, but little is known of how fatty acid delivery is affected by maternal body type or weight gain in uncomplicated pregnancies. In a cross-sectional study of maternal-neonatal pairs at term, we sought to determine the effect of gestational weight gain on neonatal LCPUFA supply...
July 28, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27338325/capsaicin-synthesis-requires-in-situ-phenylalanine-and-valine-formation-in-in-vitro-maintained-placentas-from-capsicum-chinense
#19
Fray M Baas-Espinola, Lizbeth A Castro-Concha, Felipe A Vázquez-Flota, María L Miranda-Ham
Capsaicinoids (CAP) are nitrogenous metabolites formed from valine (Val) and phenylalanine (Phe) in the placentas of hot Capsicum genotypes. Placentas of Habanero peppers can incorporate inorganic nitrogen into amino acids and have the ability to secure the availability of the required amino acids for CAP biosynthesis. In order to determine the participation of the placental tissue as a supplier of these amino acids, the effects of blocking the synthesis of Val and Phe by using specific enzyme inhibitors were analyzed...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27330572/genome-wide-placental-dna-methylation-analysis-of-severely-growth-discordant-monochorionic-twins-reveals-novel-epigenetic-targets-for-intrauterine-growth-restriction
#20
Maian Roifman, Sanaa Choufani, Andrei L Turinsky, Sascha Drewlo, Sarah Keating, Michael Brudno, John Kingdom, Rosanna Weksberg
BACKGROUND: Intrauterine growth restriction (IUGR), which refers to reduced fetal growth in the context of placental insufficiency, is etiologically heterogeneous. IUGR is associated not only with perinatal morbidity and mortality but also with adult-onset disorders, such as cardiovascular disease and diabetes, posing a major health burden. Placental epigenetic dysregulation has been proposed as one mechanism that causes IUGR; however, the spectrum of epigenetic pathophysiological mechanisms leading to IUGR remains to be elucidated...
2016: Clinical Epigenetics
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