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Fatty acid placenta

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https://www.readbyqxmd.com/read/29122468/an-intronic-variation-in-slc52a1-causes-exon-skipping-and-transient-riboflavin-responsive-multiple-acyl-coa-dehydrogenation-deficiency
#1
Signe Mosegaard, Gitte Hoffmann Bruun, Karen Freund Flyvbjerg, Yngve Thomas Bliksrud, Niels Gregersen, Maja Dembic, Ellen Annexstad, Trine Tangeraas, Rikke Katrine Jentoft Olsen, Brage S Andresen
Vitamin B2, riboflavin is essential for cellular function, as it participates in a diversity of redox reactions central to human metabolism, through its role as precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are electron carriers. The electron transfer flavoprotein (ETF) and its dehydrogenase (ETFDH), uses FAD as cofactor. The ETF and ETFDH are forming the electron transport pathway for many mitochondrial flavoprotein dehydrogenases involved in fatty acid, amino acid and choline metabolism...
November 2, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29102321/the-maternal-fetal-gradient-of-free-and-esterified-phytosterols-at-the-time-of-delivery-in-humans
#2
Alessio Correani, Silvia Visentin, Erich Cosmi, Eleonora Ponchia, Sara D'Aronco, Manuela Simonato, Luca Vedovelli, Paola Cogo, Virgilio P Carnielli
BACKGROUND: High dietary intakes of phytosterols (Phyto), such as those consumed by vegans and vegetarians, are not recommended for cholesterol-lowering in pregnant women (PW) because the safety of their use during pregnancy has not been fully established [1]. Information on Phyto in pregnancy is very limited. OBJECTIVE: To characterize the maternal-fetal gradient of free and esterified Phyto at the time of delivery in humans. DESIGN: PW who had a term delivery at the Obstetrics and Gynecology Unit of the University Hospital of Padua (Padua, Italy), between November 2016 and March 2017, participated in the study...
October 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29053802/docosahexaenoic-acid-supplementation-in-pregnancy-modulates-placental-cellular-signaling-and-nutrient-transport-capacity-in-obese-women
#3
Susanne Lager, Vanessa I Ramirez, Ometeotl Acosta, Christiane Meireles, Evelyn Miller, Francesca Gaccioli, Fredrick J Rosario, Jonathan A L Gelfond, Kevin Hakala, Susan T Weintraub, Debra A Krummel, Theresa L Powell
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid (DHA) has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function. Objective: To determine the effects of DHA supplementation in obese pregnant women on maternal metabolism and placental function...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29034330/perinatal-bisphenol-a-exposure-induces-chronic-inflammation-in-rabbit-offspring-via-modulation-of-gut-bacteria-and-their-metabolites
#4
Lavanya Reddivari, D N Rao Veeramachaneni, William A Walters, Catherine Lozupone, Jennifer Palmer, M K Kurundu Hewage, Rohil Bhatnagar, Amnon Amir, Mary J Kennett, Rob Knight, Jairam K P Vanamala
Bisphenol A (BPA) accumulates in the maturing gut and liver in utero and is known to alter gut bacterial profiles in offspring. Gut bacterial dysbiosis may contribute to chronic colonic and systemic inflammation. We hypothesized that perinatal BPA exposure-induced intestinal (and liver) inflammation in offspring is due to alterations in the microbiome and colonic metabolome. The 16S rRNA amplicon sequencing analysis revealed differences in beta diversity with a significant reduction in the relative abundances of short-chain fatty acid (SCFA) producers such as Oscillospira and Ruminococcaceae due to BPA exposure...
September 2017: MSystems
https://www.readbyqxmd.com/read/29022831/nuclear-magnetic-resonance-assisted-metabolic-analysis-of-plasma-for-mild-gestational-diabetes-mellitus-patients
#5
Bai Jin, Liping Liu, Shuxuan Zhang, Xiaohui Cao, Yuhong Xu, Junsong Wang, Lizhou Sun
AIMS: This study aimed at detecting the difference of metabolic profile in mild gestational diabetes mellitus (GDM) patients, and at identifying the correlation between the disturbed metabolites and insulin resistance pathway induced by the inflammation factors secreted by the placenta and adipocytes. MATERIALS AND METHODS: Blood samples were collected from 36 pregnant women diagnosed with mild GDM and 36 normal glucose-tolerant (NGT) pregnant women. Metabolic profiles were acquired by using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy, and the data were analyzed by multivariate statistical data analysis...
November 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28987718/fatty-acid-profile-of-maternal-and-fetal-erythrocytes-and-placental-expression-of-fatty-acid-transport-proteins-in-normal-and-intrauterine-growth-restriction-pregnancies
#6
Renata P Assumpção, Daniela B Mucci, Fernanda C P Fonseca, Henrique Marcondes, Fátima L C Sardinha, Marta Citelli, Maria G Tavares do Carmo
Long-chain polyunsaturated fatty acids (LC-PUFA), mainly docosahexaenoic (DHA) and arachidonic acids (AA), are critical for adequate fetal growth and development. We investigated mRNA expression of proteins involved in hydrolysis, uptake and/or transport of fatty acids in placenta of fifteen full term normal pregnancies and eleven pregnancies complicated by intrauterine growth restriction (IUGR) with normal umbilical blood flows. The mRNA expression of LPL, FATPs (-1, -2 and -4) and FABPs (-1 and -3) was increased in IUGR placentas, however, tissue profile of LC-PUFA was not different between groups...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28962703/docosahexaenoic-acid-dha-accretion-in-the-placenta-but-not-the-fetus-is-matched-by-plasma-unesterified-dha-uptake-rates-in-pregnant-long-evans-rats
#7
Adam H Metherel, Alex P Kitson, Anthony F Domenichiello, R J Scott Lacombe, Kathryn E Hopperton, Marc-Olivier Trépanier, Shoug M Alashmali, Lin Lin, Richard P Bazinet
Maternal delivery of docosahexaenoic acid (DHA, 22:6n-3) to the developing fetus via the placenta is required for fetal neurodevelopment, and is the only mechanism by which DHA can be accreted in the fetus. The aim of the current study was to utilize a balance model of DHA accretion combined with kinetic measures of serum unesterified DHA uptake to better understand the mechanism by which maternal DHA is delivered to the fetus via the placenta. Female rats maintained on a 2% α-linolenic acid diet free of DHA for 56 days were mated, and for balance analysis, sacrificed at 18 days of pregnancy, and fetus, placenta and maternal carcass fatty acid concentration were determined...
October 2017: Placenta
https://www.readbyqxmd.com/read/28915389/choline-prevents-fetal-overgrowth-and-normalizes-placental-fatty-acid-and-glucose-metabolism-in-a-mouse-model-of-maternal-obesity
#8
Juha Nam, Esther Greenwald, Chauntelle Jack-Roberts, Tamara T Ajeeb, Olga V Malysheva, Marie A Caudill, Kathleen Axen, Anjana Saxena, Ekaterina Semernina, Khatia Nanobashvili, Xinyin Jiang
Maternal obesity increases placental transport of macronutrients, resulting in fetal overgrowth and obesity later in life. Choline participates in fatty acid metabolism, serves as a methyl donor and influences growth signaling, which may modify placental macronutrient homeostasis and affect fetal growth. Using a mouse model of maternal obesity, we assessed the effect of maternal choline supplementation on preventing fetal overgrowth and restoring placental macronutrient homeostasis. C57BL/6J mice were fed either a high-fat (HF, 60% kcal from fat) diet or a normal (NF, 10% kcal from fat) diet with a drinking supply of either 25 mM choline chloride or control purified water, respectively, beginning 4 weeks prior to mating until gestational day 12...
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28888333/maternal-long-chain-polyunsaturated-fatty-acid-status-and-pregnancy-complications
#9
REVIEW
Nisha Wadhwani, Vidya Patil, Sadhana Joshi
Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders...
August 15, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28867101/capsaicinoids-amino-acid-and-fatty-acid-profiles-in-different-fruit-components-of-the-world-hottest-naga-king-chilli-capsicum-chinense-jacq
#10
R Ananthan, K Subhash, T Longvah
The world hottest Naga king chilli is cultivated and consumed in Northeast India. Capsaicinoids, amino acids and fatty acids were studied in fruit and fruit components of Naga king chilli. Capsaicinoid content was increased in each ripening stage and maximum level was observed at red color fruits. Total protein and fat content of placenta was 19.41 and 20.36% respectively. Capsaicinoids of placenta (7.35±2.241%) was higher followed by seed (3.83±1.358%) and pericarp (2.91±0.667%). Similarly, essential amino acid content was also higher in placenta compared to other components...
January 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28864019/glyburide-treatment-in-gestational-diabetes-is-associated-with-increased-placental-glucose-transporter-1-expression-and-higher-birth-weight
#11
Paula Díaz, Kris Genelyn Dimasuay, Lindsey Koele-Schmidt, Brian Jang, Linda A Barbour, Thomas Jansson, Theresa L Powell
Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and neonatal side effects, including increased birth weight. Placental nutrient transport is a key determinant of fetal growth, however the effect of glyburide on placental nutrient transporters is largely unknown. We hypothesized that glyburide treatment in GDM pregnancies is associated with increased expression of nutrient transporters in the syncytiotrophoblast plasma membranes. We collected placentas from GDM pregnancies who delivered at term and were treated with either diet modification (n = 15) or glyburide (n = 8)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28864004/maternal-bmi-and-gestational-diabetes-alter-placental-lipid-transporters-and-fatty-acid-composition
#12
Maria Teresa Segura, Hans Demmelmair, Susanne Krauss-Etschmann, Petra Nathan, Stefan Dehmel, Maria Carmen Padilla, Ricardo Rueda, Berthold Koletzko, Cristina Campoy
INTRODUCTION: Placental fatty acid (FA) uptake and metabolism depend on maternal supply which may be altered when women have a high pre-pregnancy body mass index (BMI) or develop gestational diabetes (GDM). Consequently, an impaired FA transport to the fetus may negatively affect fetal development. While placental adaptation of maternal-fetal glucose transfer in mild GDM has been described, knowledge on placental FA acid metabolism and possible adaptations in response to maternal obesity or GDM is lacking...
September 2017: Placenta
https://www.readbyqxmd.com/read/28798692/change-in-the-lipid-transport-capacity-of-the-liver-and-blood-during-reproduction-in-rats
#13
Yufeng Zhang, Christine Kallenberg, Hayden W Hyatt, Andreas N Kavazis, Wendy R Hood
To support the high energetic demands of reproduction, female mammals display plasticity in many physiological processes, such as the lipid transport system. Lipids support the energy demands of females during reproduction, and energy and structural demands of the developing offspring via the placenta in utero or milk during the suckling period. We hypothesized that key proteins supporting lipid transport in reproductive females will increase during pregnancy and lactation, but drop to non-reproductive levels shortly after reproduction has ended...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28797150/-expression-of-peroxisome-proliferator-activated-receptors-fatty-acid-binding-protein-4-in-placenta-and-their-correlations-with-the-prognosis-of-pre-eclampsia
#14
Y Li, W L Chen, L Liu, H Gu
Objective: To examine the mRNA and protein expression of peroxisome proliferator-activated receptors (PPAR) and fatty acid binding protein-4 (FABP-4) in placenta, and to investigate their correlation with the prognosis of pre-eclampsia. Methods: The data of 177 women who delivered from January 2013 to December 2015 in Chinese People's Liberation Army No.94 Hospital were collected. Among them, 60 cases were term pregnancy and not in labor (TN); 46 cases were term pregnancy with preeclampsia and not in labor (TPE); 42 cases were preterm pregnancy and not in labor (PN); 29 cases were preterm pregnancy with pre-eclampsia and not in labor (PPE)...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28751269/impaired-mitochondrial-fusion-autophagy-biogenesis-and-dysregulated-lipid-metabolism-is-associated-with-preeclampsia
#15
Xiaobo Zhou, Ting-Li Han, Hong Chen, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia(PE) is a pregnancy complication that is diagnosed by the new onset of hypertension and proteinuria. The etiology of PE remains unclear; however, growing evidence indicates that mitochondrial impairment contributes to the pathogenesis. Therefore, we aim to investigate the function of mitochondria in the development of PE. The mitochondrial metabolome in preeclamptic (n = 11) and normal (n = 11) placentas were analyzed using Gas chromatography-mass spectrometry (GC-MS). Student's t-tests and receiver operating characteristic (ROC) curves were conducted to determine which mitochondrial metabolites differed significantly between the two groups...
October 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28733353/use-of-proteomics-to-investigate-kidney-function-decline-over-5-years
#16
Axel C Carlsson, Erik Ingelsson, Johan Sundström, Juan Jesus Carrero, Stefan Gustafsson, Tobias Feldreich, Markus Stenemo, Anders Larsson, Lars Lind, Johan Ärnlöv
BACKGROUND AND OBJECTIVES: Using a discovery/replication approach, we investigated associations between a multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, and eGFR decline per year and CKD incidence. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used two cohorts, the Prospective Investigation of the Vasculature in Uppsala Seniors Study (PIVUS; n=687, mean age of 70 years, 51% women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=360 men, mean age of 78 years), with 5-year follow-up data on eGFR...
July 21, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28727047/a-diet-supplemented-with-n-3-polyunsaturated-fatty-acids-influences-the-metabomscic-and-endocrine-response-of-rabbit-does-and-their-offspring
#17
M Rodríguez, R M García-García, M Arias-Álvarez, N Formoso-Rafferty, P Millán, J López-Tello, P L Lorenzo, A González-Bulnes, P G Rebollar
The aim of the present study was to evaluate the productive, endocrine, and metabomscic responses as well as oxidative stress of rabbit does and their offspring when fed a diet supplemented with -3 PUFA during their first productive cycle. To this aim, a total of 105 rabbit does were fed ad mscibitum from d 60 to 172 of age 2 isoenergetic and isoproteic diets differing in fatty acid composition. The control diet ( = 52 does) contained 45.9 g/kg of -3 of the total fatty acids and the enriched diet ( = 53 does) contained 149...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28635162/chlamydia-trachomatis-is-responsible-for-lipid-vacuolation-in-the-amniotic-epithelium-of-fetal-gastroschisis
#18
Marcia L Feldkamp, Diane M Ward, Theodore J Pysher, Christina T Chambers
BACKGROUND: Vacuolated amniotic epithelium with lipid droplets in gastroschisis placentas is an unusual finding. Mass spectrometry of lipid droplets identified triglycerides, ester-linked to an unusual pattern of fatty acids. We hypothesize that these findings result from a Chlamydia trachomatis infection during the periconceptional period. The rising incidence of chlamydia infections has paralleled the increasing prevalence of gastroschisis among women less than 25 years of age. Histologically, young women are at greatest risk for a chlamydia infection due to their immature columnar epithelium, the preferential site for attachment of Chlamydia trachomatis infectious particle (elementary body)...
June 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/28588199/contributions-of-the-maternal-oral-and-gut-microbiome-to-placental-microbial-colonization-in-overweight-and-obese-pregnant-women
#19
Luisa F Gomez-Arango, Helen L Barrett, H David McIntyre, Leonie K Callaway, Mark Morrison, Marloes Dekker Nitert
A distinct bacterial signature of the placenta was reported, providing evidence that the fetus does not develop in a sterile environment. The oral microbiome was suggested as a possible source of the bacterial DNA present in the placenta based on similarities to the oral non-pregnant microbiome. Here, the possible origin of the placental microbiome was assessed, examining the gut, oral and placental microbiomes from the same pregnant women. Microbiome profiles from 37 overweight and obese pregnant women were examined by 16SrRNA sequencing...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588000/effect-of-maternal-obesity-on-fetal-growth-and-the-expression-of-placental-fatty-acid-transporters
#20
Kui Ye, Li Li, Dan Zhang, Yi Li, Hai Qing Wang, Han Lin Lai, Chuan Lai Hu
OBJECTIVE: To explore the effects of maternal high-fat diet induced obesity on fetal growth and the expression of placental nutrient transporters. METHODS: Maternal obesity was established in rats by 8 weeks of pre-pregnancy high-fat (HF) diet feeding, while rats in the control group were fed with normal (CON) diet. Diet induced obesity (DIO) rats and diet induced obesity resistant (DIR) rats were selected according to body weight gain over this period. After copulation, the CON rats were divided into two groups: switched to HF diet (CON-HF group) or maintained on the CON diet (CON-CON group)...
June 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
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