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Lipid membrane disease

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https://www.readbyqxmd.com/read/29352432/effect-of-membrane-composition-on-receptor-association-implications-of-cancer-lipidomics-on-erbb-receptors
#1
REVIEW
Aiswarya B Pawar, Durba Sengupta
The association of single transmembrane receptors, such as the ErbB receptors is a key event in initiating cell signaling networks. The interactions between these receptors have been well characterized for both ligand-driven and pre-formed dimers. However, the role of the membrane in modulating association is less well understood and assumes greater importance in light of altered membrane composition in diseased states. Here, we discuss how membrane composition has been observed to induce both structural and dynamic differences in receptor association...
January 19, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29348720/gintonin-absorption-in-intestinal-model-systems
#2
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin exhibits anti-Alzheimer disease effects in model mice. However, little is known about the intestinal absorption of gintonin. The aim of this study was to investigate gintonin absorption using two model systems...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29345374/ship-negatively-regulates-type-ii-immune-responses-in-mast-cells-and-macrophages
#3
REVIEW
Peter Dobranowski, Laura M Sly
SHIP is a hematopoietic-specific lipid phosphatase that dephosphorylates PI3K-generated PI(3,4,5)-trisphosphate. SHIP removes this second messenger from the cell membrane blunting PI3K activity in immune cells. Thus, SHIP negatively regulates mast cell activation downstream of multiple receptors. SHIP has been referred to as the "gatekeeper" of mast cell degranulation as loss of SHIP dramatically increases degranulation or permits degranulation in response to normally inert stimuli. SHIP also negatively regulates Mϕ activation, including both pro-inflammatory cytokine production downstream of pattern recognition receptors, and alternative Mϕ activation by the type II cytokines, IL-4, and IL-13...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29342096/high-resolution-lipidomics-of-the-early-life-stages-of-the-red-seaweed-porphyra-dioica
#4
Elisabete da Costa, Vitor Azevedo, Tânia Melo, Andreia M Rego, Dmitry V Evtuguin, Pedro Domingues, Ricardo Calado, Rui Pereira, Maria H Abreu, Maria R Domingues
Porphyra dioica is a commercial seaweed consumed all over the world, mostly in the shape of nori sheets used for "sushi" preparation. It is a well-known part of the Asian diet with health benefits, which have been associated, among others, to the high levels of n-3 and n-6 fatty acids in this red alga. However, other highly valued lipids of Porphyra are polar lipids that remain largely undescribed and can have both nutritional value and bioactivity, thus could contribute to the valorization of this seaweed...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29335600/alteration-in-fluidity-of-cell-plasma-membrane-in-huntington-disease-revealed-by-spectral-phasor-analysis
#5
Sara Sameni, Leonel Malacrida, Zhiqun Tan, Michelle A Digman
Huntington disease (HD) is a late-onset genetic neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide in the exon 1 of the gene encoding the polyglutamine (polyQ). It has been shown that protein degradation and lipid metabolism is altered in HD. In many neurodegenerative disorders, impaired lipid homeostasis is one of the early events in the disease onset. Yet, little is known about how mutant huntingtin may affect phospholipids membrane fluidity. Here, we investigated how membrane fluidity in the living cells (differentiated PC12 and HEK293 cell lines) are affected using a hyperspectral imaging of widely used probes, LAURDAN...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331881/ameliorative-role-of-genistein-against-age-dependent-chronic-arsenic-toxicity-in-murine-brains-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades
#6
Sukanya Saha, Pritam Sadhukhan, Sushweta Mahalanobish, Sayanta Dutta, Parames C Sil
Brain is highly prone to oxidative damage due to its huge lipid content and extensive energy requirements. Exogenous insult in brain via oxidative injury can lead to severe pathophysiological conditions. Age-dependent deterioration of normal brain functions is also noteworthy. Genistein, a polyphenolic isoflavonoid, obtained from the soy plant, is well known to protect against several diseased conditions. Here, in this study chronic brain toxicity model was developed using oral administration of arsenic for 90 days in adult and aged murines...
December 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29330108/membrane-lipid-associated-lncrna-a-new-regulator-in-cancer-signaling
#7
Yanxiu Ma, Junmei Zhang, Lixia Wen, Aifu Lin
Long noncoding RNAs (LncRNAs) are one of the emerging regulators which are involved in diverse biological processes. LncRNAs can participate in the regulation of gene expression via various ways in the cytoplasm and the nucleus. The function of the nuclear lncRNAs has been studied a lot. Recent studies have shown that the regulatory roles of cytoplasmic lncRNA, including membrane lipid associated lncRNA, may open an unexplored mechanistic territory. LncRNA dysregulated expression represents a common event in pathogenesis of a variety of human genetic diseases including cancer...
January 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29325602/bile-acid-metabolism-in-liver-pathobiology
#8
John Y L Chiang, Jessica M Ferrell
Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile acid metabolism is tightly regulated by bile acid synthesis in the liver and bile acid biotransformation in the intestine. Bile acids are endogenous ligands that activate a complex network of nuclear receptor farnesoid X receptor and membrane G protein-coupled bile acid receptor-1 to regulate hepatic lipid and glucose metabolic homeostasis and energy metabolism...
January 11, 2018: Gene Expression
https://www.readbyqxmd.com/read/29323916/influence-of-eugenol-on-the-organization-and-dynamics-of-lipid-membranes-a-phase-dependent-study
#9
Geetanjali Meher, Hirak Chakraborty
Eugenol is known for its antimicrobial effects against microorganisms responsible for infectious diseases in human, food borne pathogens and oral pathogens. In spite of several reports on the antimicrobial function of eugenol by modulating the structural properties of cell membrane there was no direct information on the influence of eugenol in the lipid membrane. In this work, we explored the effect of eugenol on organization and dynamics of large unilamellar vesicles (LUVs) of DMPC using the intrinsic fluorescence of eugenol and an extrinsic hydrophobic probe, DPH, in varying phases...
January 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29323763/calcium-responsive-liposomes-via-a-synthetic-lipid-switch
#10
Jinchao Lou, Adam Carr, Alexa Watson, Samuel Mattern-Schain, Michael D Best
Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium, a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium responsive lipid switch 1, designed to undergo conformational changes upon calcium binding that perturb membrane integrity, thereby promoting release. This was shown through fluorescence-based release assays via dose-dependent response depending on the percentage of 1 in liposomes, with minimal background leakage in controls...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29323721/brain-derived-neurotrophic-factor-modulates-cholesterol-homeostasis-and-apolipoprotein-e-synthesis-in-human-cell-models-of-astrocytes-and-neurons
#11
Maria Stefania Spagnuolo, Aldo Donizetti, Lucia Iannotta, Vincenza Aliperti, Chiara Cupidi, Amalia Cecilia Bruni, Luisa Cigliano
In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism has been associated with different diseases. Brain-derived neurotrophic factor (BDNF) was previously reported to elicit cholesterol biosynthesis and promote the accumulation of presynaptic proteins in cholesterol-rich lipid rafts, but no data are available on its ability to modulate physiological mechanisms involved in cholesterol homeostasis...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323104/the-mechanism-of-glycosphingolipid-degradation-revealed-by-a-galc-sapa-complex-structure
#12
Chris H Hill, Georgia M Cook, Samantha J Spratley, Stuart Fawke, Stephen C Graham, Janet E Deane
Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin proteins and hydrolytic enzymes. The glycosphingolipid galactocerebroside is the primary lipid component of the myelin sheath and is degraded by the hydrolase β-galactocerebrosidase (GALC). This enzyme requires the saposin SapA for lipid processing and defects in either of these proteins causes a severe neurodegenerative disorder, Krabbe disease...
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321393/-n-3-fatty-acids-and-the-maintenance-of-neuronal-functions
#13
Michio Hashimoto
The functions of n-3 fatty acids are known to be diverse, and they play roles in cardiovascular and neuronal systems and in lipid metabolism. Docosahexaenoic acid (DHA), which is the most abundant n-3 fatty acid in the brain, is essential for the maintenance of brain functions throughout the human lifespan. Epidemiological studies have demonstrated that reduced n-3 fatty acid intake is closely associated with the onset of mental and neurological diseases such as brain developmental disorders, depression, and Alzheimer's disease...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29320578/the-potent-effect-of-mycolactone-on-lipid-membranes
#14
Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated...
January 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29317695/alterations-in-the-properties-of-the-cell-membrane-due-to-glycosphingolipid-accumulation-in-a-model-of-gaucher-disease
#15
Gyula Batta, Lilla Soltész, Tamás Kovács, Tamás Bozó, Zoltán Mészár, Miklós Kellermayer, János Szöllősi, Peter Nagy
Gaucher disease is a lysosomal storage disease characterized by the malfunction of glucocerebrosidase resulting in the accumulation of glucosylceramide and other sphingolipids in certain cells. Although the disease symptoms are usually attributed to the storage of undigested substrate in lysosomes, here we show that glycosphingolipids accumulating in the plasma membrane cause profound changes in the properties of the membrane. The fluidity of the sphingolipid-enriched membrane decreased accompanied by the enlargement of raft-like ordered membrane domains...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#16
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315863/activatable-protein-nanoparticles-for-targeted-delivery-of-therapeutic-peptides
#17
Xi Yu, Xingchun Gou, Peng Wu, Liang Han, Daofeng Tian, Fengyi Du, Zeming Chen, Fuyao Liu, Gang Deng, Ann T Chen, Chao Ma, Jun Liu, Sara M Hashmi, Xing Guo, Xiaolong Wang, Haitian Zhao, Xinran Liu, Xudong Zhu, Kevin Sheth, Qianxue Chen, Louzhen Fan, Jiangbing Zhou
Clinical translation of therapeutic peptides, particularly those that require penetration of the cell membrane or are cytolytic, is a major challenge. A novel approach based on a complementary mechanism, which has been widely used for guided synthesis of DNA or RNA nanoparticles, for de novo design of activatable protein nanoparticles (APNPs) for targeted delivery of therapeutic peptides is described. APNPs are formed through self-assembly of three independent polypeptides based on pairwise coiled-coil dimerization...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29315013/on-the-evolution-of-bile-salts-and-the-farnesoid-x-receptor-in-vertebrates
#18
Kim Frisch, Aage Kristian Olsen Alstrup
In recent decades, our knowledge of bile salts has undergone a vast development, and bile salts are now known not only for their detergent properties that aid in the absorption of dietary lipids but also for their interaction with specific nuclear and membrane receptors. In particular, it has been realized that the response of the farnesoid X receptor (FXR) to bile acids provides a signal bridge between the liver and small intestine, controlling the intracellular levels, biosynthesis, and enterohepatic circulation of bile acids...
March 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29314568/genetic-determinants-of-hepatic-steatosis-and-serum-cytokeratin-18-fragment-levels-in-taiwanese-children
#19
Yu-Cheng Lin, Pi-Feng Chang, Mei-Hwei Chang, Yen-Hsuan Ni
BACKGROUND/AIMS: There are substantial genetic components contributing to the susceptibility of nonalcoholic NAFLD disease (NAFLD). It has recently been reported that the rs641738 C>T variant in the membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene increased severity of NAFLD in adults of European descent. We aimed to test the hypothesis that MBOAT7 rs641738 variant would increase hepatic steatosis and hepatocellular injury in obese children. METHODS: A total of 831 obese children aged 7-15 years were recruited...
January 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29313342/a-microfluidic-diffusion-platform-for-characterizing-the-size-of-lipid-vesicles-and-the-thermodynamics-of-protein-lipid-interactions
#20
Hongze Gang, Celine Galvagnion, Georg Meisl, Thomas Müller, Alexander K Buell, Aviad Levin, Christopher M Dobson, Bo-Zhong Mu, Tuomas P J Knowles
Elucidation of the fundamental interactions of proteins with biological membranes under native conditions is crucial for understanding the molecular basis of their biological function and malfunction. Notably, the large surface to volume ratio of living cells provides a molecular landscape for significant interactions of cellular components with membranes modulating their function. However, such interactions can be challenging to probe using conventional biophysical methods due to the heterogeneity of the species and processes involved...
January 9, 2018: Analytical Chemistry
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