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https://www.readbyqxmd.com/read/29475156/potent-hydrazone-derivatives-targeting-esophageal-cancer-cells
#1
Ling-Yu Li, Jia-Di Peng, Wenjuan Zhou, Hui Qiao, Xin Deng, Zhou-Hua Li, Ji-Deng Li, Yun-Dong Fu, Song Li, Kai Sun, Hong-Min Liu, Wen Zhao
Hydrazone and their derivatives are a series of highly active molecules, which are widely used as lead compounds for the research and development of new anti-cancer drugs. In this study, 20 compounds were synthesized, based on this scaffold and their in vitro cytotoxicity against 6 cancer cell lines, including EC9706, SMMC-7721, MCF7, PC3, MGC-803 and EC109 was tested. Among them, compound 6p, showed strong anti-proliferative activities on esophageal carcinoma cells: EC9706 and EC109 with IC50 values of 1...
February 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29475140/the-prognostic-relevance-of-sentinel-lymph-node-metastases-assessed-by-phgr1-mrna-quantification-in-stage-i-to-iii-colon-cancer
#2
Satu Oltedal, Hartwig Kørner, Ole Gunnar Aasprong, Israr Hussain, Kjersti Tjensvoll, Rune Smaaland, Jon Arne Søreide, Kjetil Søreide, Ragnhild A Lothe, Reino Heikkilä, Bjørnar Gilje, Oddmund Nordgård
BACKGROUND: Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN) metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases...
February 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29475060/lanatoside-c-inhibits-cell-proliferation-and-induces-apoptosis-through-attenuating-wnt-%C3%AE-catenin-c-myc-signaling-pathway-in-human-gastric-cancer-cell
#3
Yudong Hu, Kaikai Yu, Gang Wang, Depeng Zhang, Chaoji Shi, Yunhe Ding, Duo Hong, Dan Zhang, Huiqiong He, Lei Sun, Jun-Nian Zheng, Shuyang Sun, Feng Qian
Gastric cancer is the third common cause of cancer mortality in the world with poor prognosis and high recurrence due to lack of effective medicines. Our studies revealed that lanatoside C, a FDA-approved cardiac glycoside, had an anti-proliferation effect on different human cancer cell lines (MKN-45; SGC-7901; HN4; MCF-7; HepG2) and gastric cell lines MKN-45 and SGC-7901 were the most sensitive cell lines to lanatoside C. MKN-45 cells treated with lanatoside C showed cell cycle arrest at G2/M phase and inhibition of cell migration...
February 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29474365/ultra-fast-vitrification-of-patient-derived-circulating-tumor-cell-lines
#4
Rebecca D Sandlin, Keith H K Wong, Shannon N Tessier, Anisa Swei, Lauren D Bookstaver, Bennett E Ahearn, Shyamala Maheswaran, Daniel A Haber, Shannon L Stott, Mehmet Toner
Emerging technologies have enabled the isolation and characterization of rare circulating tumor cells (CTCs) from the blood of metastatic cancer patients. CTCs represent a non-invasive opportunity to gain information regarding the primary tumor and recent reports suggest CTCs have value as an indicator of disease status. CTCs are fragile and difficult to expand in vitro, so typically molecular characterization must be performed immediately following isolation. To ease experimental timelines and enable biobanking, cryopreservation methods are needed...
2018: PloS One
https://www.readbyqxmd.com/read/29474243/anticipating-the-impact-of-human-papillomavirus-vaccination-on-us-cervical-cancer-prevention-strategies
#5
L Stewart Massad
Cervical cancer prevention guidelines are benchmarked to risk of cervical precancer. In younger age cohorts, vaccination against high-risk types of human papillomavirus (HPV) has reduced HPV 16/18 prevalence and cervical intraepithelial neoplasia. Lower prevalence of precancer will impair the sensitivity of cytology and colposcopy, but negative predictive value will rise. Training and skills maintenance will become more difficult as abnormalities become less common. Primary screening with HPV assays will become more attractive but will require HPV genotyping as most positive HPV tests will reflect non-16/18 infections with lower oncogenicity...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29474181/health-related-quality-of-life-of-patients-with-hpv-related-cancers-in-indonesia
#6
Didik Setiawan, Arrum Dusafitri, Githa Fungie Galistiani, Antoinette D I van Asselt, Maarten J Postma
BACKGROUND: Human papillomavirus (HPV)-related cancers are a serious concern in developing countries. Valid estimates of a country-specific health-related quality of life (HRQOL) for patients with HPV-related cancers provide a substantial tool in determining the burden of the disease. OBJECTIVES: To investigate the HRQOL of patients with HPV-related cancers in Indonesia. METHODS: The HRQOL of patients with HPV-related cancers (cervical, uterine, nasopharyngeal, head and neck, and anogenital cancer) was assessed using the EuroQol five-dimensional questionnaire (EQ-5D)...
September 3, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474178/a-comparison-of-eq-5d-3l-index-scores-using-malaysian-singaporean-thai-and-uk-value-sets-in-indonesian-cervical-cancer-patients
#7
Dwi Endarti, Arthorn Riewpaiboon, Montarat Thavorncharoensap, Naiyana Praditsitthikorn, Raymond Hutubessy, Susi Ari Kristina
OBJECTIVES: To gain insight into the most suitable foreign value set among Malaysian, Singaporean, Thai, and UK value sets for calculating the EuroQol five-dimensional questionnaire index score (utility) among patients with cervical cancer in Indonesia. METHODS: Data from 87 patients with cervical cancer recruited from a referral hospital in Yogyakarta province, Indonesia, from an earlier study of health-related quality of life were used in this study. The differences among the utility scores derived from the four value sets were determined using the Friedman test...
September 1, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474159/detecting-receptor-tyrosine-kinase-ror1-using-a-developed-anti-ror1-polyclonal-antibody
#8
Azam Hemmati, Hadi Hassannia, Saeideh Milani, Reza Hadavi, Fatemeh Ghaemimanesh, Hodjattallah Rabbani
Receptor tyrosine kinase ROR1 has been introduced as an interesting prognostic cancer marker in histopathology. The aim of this study was to produce a polyclonal antibody (PAb) against recombinant human ROR1 protein to be used as a tool for investigation of ROR1 expression in human cancer tissue blocks. The extracellular part of human ROR1 recombinant protein was expressed using pET-28b(+) plasmid in Escherichia coli Bl21(DE3) host. The recombinant ROR1, as a candidate immunogen, was purified and injected to a New Zealand rabbit...
February 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29473992/radical-prostatectomy-and-the-effect-of-close-surgical-margins-results-from-the-search-database
#9
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
https://www.readbyqxmd.com/read/29473960/breast-specific-factors-determine-cosmetic-outcome-and-patient-satisfaction-after-breast-conserving-therapy-results-from-the-randomized-cobalt-study
#10
José H Volders, Vera L Negenborn, Max H Haloua, Nicole M A Krekel, Katarzyna Jóźwiak, Sybren Meijer, Petrousjka M van den Tol
BACKGROUND AND OBJECTIVES: To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS: Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with T1-T2 breast cancer completed a questionnaire on breast-specific factors and overall cosmetic outcome and patient satisfaction, using a 4-point Likert scale...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473860/carcinoembryonic-antigen-serum-levels-in-nonmelanoma-skin-cancer
#11
Saverio Latteri, Vito Emanuele Catania, Giulia Malaguarnera, Andrea Peri, Gaetano Bertino, Giuseppe Frazzetto, Antonio Maria Borzì, Antonio Biondi, Rosario Emanuele Perrotta, Michele Malaguarnera
BACKGROUND: Carcinoembryonic antigen (CEA) is a glycoprotein, which is present in the foetal colon, some benign conditions and different malignancies, particularly in colon adenocarcinoma. We focused this study on non-melanoma skin cancer (NMSC). NMSC is a common malignancy and it is an important source of morbidity and death in the world. In this study we evaluated whether CEA level increases in NMSC. PATIENTS AND METHODS: A total of 566 patients with non-melanoma skin cancer (NMSC) were enrolled; 286 patients with NMSC showed CEA levels above normal values, and 280 showed CEA levels below normal values...
February 23, 2018: Biomedicines
https://www.readbyqxmd.com/read/29473838/-nano-ginseng-for-enhanced-cytotoxicity-against-cancer-cells
#12
Lin Dai, Weiyan Zhu, Chuanling Si, Jiandu Lei
Panax ginseng has high medicinal and health values. However, the various and complex components of ginseng may interact with each other, thus reducing and even reversing therapeutic effects. In this study, we designed and fabricated a novel "nano-ginseng" with definite ingredients, ginsenoside Rb1/protopanaxadiol nanoparticles (Rb1/PPD NPs), completely based on the protopanaxadiol-type extracts. The optimized nano-formulations demonstrated an appropriate size (~110 nm), high drug loading efficiency (~96...
February 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29473696/developing-and-testing-a-brief-clinic-based-lung-cancer-screening-decision-aid-for-primary-care-settings
#13
Karen Kane McDonnell, Scott M Strayer, Erica Sercy, Callie Campbell, Daniela B Friedman, Kathleen B Cartmell, Jan M Eberth
BACKGROUND: Cancer screening-related decisions require patients to evaluate complex medical information in short time frames, often with primary care providers (PCPs) they do not know. PCPs play an essential role in facilitating comprehensive shared decision making (SDM). OBJECTIVE: To develop and test a decision aid (DA) and SDM strategy for PCPs and high-risk patients. DESIGN: The DA was tested with 20 dyads. Each dyad consisted of one PCP and one patient eligible for screening...
February 23, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29473437/anti-breast-cancer-triterpenoid-saponins-from-the-thorns-of-gleditsia-sinensis
#14
Jinqian Yu, Gang Li, Yan Mu, Honglei Zhou, Xiao Wang, Peng Yang
One new triterpenoid saponin (1), as well as six known ones (2-7), were isolated from the ethanol extract of the thorns of Gleditsia sinensis. Their structures were elucidated by extensive spectroscopic analysis in conjunction with chemical evidence. Cytotoxic activity of compounds 1-6 was evaluated against human breast cancer MCF 7 cells in vitro by the MTT method. Our results revealed moderate activities for compounds 1-6 with IC50 values of 18.43, 30.47, 18.46, 10.02, 30.76, and 17.32 μM, respectively...
February 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29473377/the-correlation-between-biological-activity-and-diffusion-weighted-mr-imaging-and-adc-value-in-cases-with-prostate-cancer
#15
Bedriye Koyuncu Sokmen, Dogukan Sokmen, Nese Ucar, Huseyin Ozkurt, Abdulmuttalip Simsek
PURPOSE: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. METHODS: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473374/the-association-between-prostatitis-and-prostate-cancer-systematic-review-and-meta-analysis
#16
Gianpaolo Perletti, Elena Monti, Vittorio Magri, Tommaso Cai, Anne Cleves, Alberto Trinchieri, Emanuele Montanari
OBJECTIVE: The main outcome of this review was the association between a history of clinical chronic prostatitis (NIH category II or III) and a histologically confirmed diagnosis of prostate cancer. MATERIALS AND METHODS: Crude odds ratios and 95% confidence intervals (CI) were calculated to analyze dichotomous data. For analysis of pooled data we adopted a random-effects model and the inverse variance weighing method. Heterogeneity was assessed by calculating the I2 value...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473373/medical-management-in-locally-advanced-and-metastatic-prostate-cancer-does-changes-in-treatment-policy-have-any-specific-effect-on-psa-levels
#17
Murat Bagcioglu, Cristian Surcel, Serkan Ozcan, Cristian Mirvald, Mehmet Ali Karagoz, Mert Ali Karadag, Emre Huri, Kemal Sarica
OBJECTIVE: Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of initial ADT. We aimed to investigate the effect of changes in treatment on PSA and testosterone levels. MATERIAL AND METHODS: A total of 120 patients with an established diagnosis of either locally advanced or metastatic Pca in two different centers...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473345/cgb5-expression-is-independently-associated-with-poor-overall-survival-and-recurrence-free-survival-in-patients-with-advanced-gastric-cancer
#18
Yuxin Yang, Yonghong Shi, Yanjuan Hou, Ying Lu, Jinliang Yang
The human CGB5 gene encodes chorionic gonadotropin (hCG)β 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiation, growth, and metastatic outgrowth. In this study, using data from the International Cancer Genome Consortium (ICGC) and the Cancer Genome Atlas (TCGA)-stomach adenocarcinoma (STAD), we assessed the independent prognostic value of CGB5 expression in patients with primary gastric cancer (GC)...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473340/a-nomogram-incorporating-six-easily-obtained-parameters-to-discriminate-intrahepatic-cholangiocarcinoma-and-hepatocellular-carcinoma
#19
Mengmeng Wang, Yuzhen Gao, Huijuan Feng, Elisa Warner, Mingrui An, Jian'an Jia, Shipeng Chen, Meng Fang, Jun Ji, Xing Gu, Chunfang Gao
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are the most prevalent histologic types of primary liver cancer (PLC). Although ICC and HCC share similar risk factors and clinical manifestations, ICC usually bears poorer prognosis than HCC. Confidently discriminating ICC and HCC before surgery is beneficial to both treatment and prognosis. Given the lack of effective differential diagnosis biomarkers and methods, construction of models based on available clinicopathological characteristics is in need...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473326/prediction-of-radiotherapy-response-with-a-5-microrna-signature-based-nomogram-in-head-and-neck-squamous-cell-carcinoma
#20
Lin Chen, Yihui Wen, Jingwei Zhang, Wei Sun, Vivian W Y Lui, Yi Wei, Fenghong Chen, Weiping Wen
Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)-based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation set (n = 153)...
February 23, 2018: Cancer Medicine
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