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https://www.readbyqxmd.com/read/29791951/nervous-system-infections-and-the-global-traveler
#1
Savina Reid, Haley Thompson, Kiran T Thakur
Neurological complications of infectious diseases are associated with high rates of morbidity and mortality. It is imperative that neurologists be up-to-date on current developments including typical and atypical presentations of neurological infections in travelers, diagnostic and treatment recommendations, and emerging pathogen resistance patterns to avoid fatal outcomes and long-term sequelae. This article will address concepts of emerging and reemerging infectious diseases, and will provide updates on the neurological manifestations of select emerging and reemerging infections, including Ebola virus, bacterial meningitis, enterovirus 71, Zika virus, cerebral malaria, and Japanese encephalitis...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791949/the-global-neurological-burden-of-tuberculosis
#2
Kiran Thakur, Mitashee Das, Kelly E Dooley, Amita Gupta
Central nervous system (CNS) involvement of tuberculosis (TB) is the most severe manifestation of TB and accounts for approximately 5 to 10% of all extrapulmonary TB (EPTB) cases and approximately 1% of all TB cases. TB meningitis (TBM) is the most common form of CNS TB, though other forms occur, often in conjunction with TBM, including intracranial tuberculomas, tuberculous brain abscesses, and spinal tubercular arachnoiditis. CNS TB often presents with nonspecific clinical features that mimic symptoms of other neurological conditions, often making diagnosis difficult...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29788431/novel-treatment-of-cryptococcal-meningitis-via-neurapheresistm-therapy
#3
Gordon J Smilnak, Lefko T Charalambous, Drew Cutshaw, Alykhan M Premji, Charles D Giamberardino, Christi G Ballard, Andrew P Bartuska, Tiffany U Ejikeme, Huaxin Sheng, Laura Zitella Verbick, Blake A Hedstrom, Promila C Pagadala, Aaron R McCabe, John R Perfect, Shivanand P Lad
Cryptococcal meningitis (CM) has emerged as the most common life-threatening fungal meningitis worldwide. Current management involves a sequential, longitudinal regimen of antifungals; despite a significant improvement in survival compared to uniform mortality without treatment, this drug paradigm has not led to a consistent cure. NeurapheresisTM therapy, extracorporeal filtration of yeasts from cerebrospinal fluid (CSF) in infected hosts, is presented here as a novel, one-time therapy for CM. In vitro filtration of CSF through this platform yielded a five-log reduction in concentration of the yeast and a one-log reduction in its polysaccharide antigen over 24 hours...
May 17, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29784512/epidemiology-and-etiology-of-invasive-bacterial-infection-in-infants-%C3%A2-60-days-old-treated-in-emergency-departments
#4
Christopher Woll, Mark I Neuman, Christopher M Pruitt, Marie E Wang, Eugene D Shapiro, Samir S Shah, Russell J McCulloh, Lise E Nigrovic, Sanyukta Desai, Adrienne G DePorre, Rianna C Leazer, Richard D Marble, Fran Balamuth, Elana A Feldman, Laura F Sartori, Whitney L Browning, Paul L Aronson
OBJECTIVES: To help guide empiric treatment of infants ≤60 days old with suspected invasive bacterial infection by describing pathogens and their antimicrobial susceptibilities. STUDY DESIGN: Cross-sectional study of infants ≤60 days old with invasive bacterial infection (bacteremia and/or bacterial meningitis) evaluated in the emergency departments of 11 children's hospitals between July 1, 2011 and June 30, 2016. Each site's microbiology laboratory database or electronic medical record system was queried to identify infants from whom a bacterial pathogen was isolated from either blood or cerebrospinal fluid...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#5
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29751133/the-threat-of-meningococcal-disease-during-the-hajj-and-umrah-mass-gatherings-a-comprehensive-review
#6
REVIEW
Saber Yezli
The Hajj and Umrah mass gatherings represent many of the risk factors for meningococcal disease and have historically been associated with both local and international outbreaks of the disease. The implementation of strict preventative measures including mandatory meningococcal vaccination with the quadrivalent (A,C,Y,W) vaccine has prevented pilgrimage-associated meningococcal outbreaks and significantly reduced the incidence of the disease at these events. However, meningococcal disease remains an important public health threat at the Hajj and Umrah due in part to the evolving nature of the disease, characterized with diverse and varying geographic trends, fluctuations in incidence and shifts in serogroups and genotypes...
May 8, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29743769/cerebrospinal-fluid-lactate-as-a-prognostic-indicator-in-postneurosurgical-bacterial-meningitis-and-use-of-intrathecal-colistin
#7
Pradeepkumar Hiremath, Pradeep Rangappa, Ipe Jacob, Karthik Rao
Postneurosurgical bacterial meningitis (PNBM) is an emergency and requires early diagnosis and treatment with appropriate antibiotics. The cornerstone of diagnosis is microbiological analysis of the cerebrospinal fluid (CSF) cytochemical characteristics such as leucocyte count, CSF glucose, and protein concentration and CSF: Serum glucose ratio. However, this is often misleading in PNBM. The role of CSF lactate assay for diagnosis and prognosis has been debated. This case report looks into the serial measurement of CSF lactates in PNBM...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29740328/emerging-role-of-endo-cannabinoids-in-migraine
#8
REVIEW
Pinja Leimuranta, Leonard Khiroug, Rashid Giniatullin
In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ECS) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive CB1 and CB2 and pro-nociceptive TRPV1 receptors...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29735685/acquisition-of-virulence-genes-by-a-carrier-strain-gave-rise-to-the-ongoing-epidemics-of-meningococcal-disease-in-west-africa
#9
Ola Brønstad Brynildsrud, Vegard Eldholm, Jon Bohlin, Kennedy Uadiale, Stephen Obaro, Dominique A Caugant
In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. After gradual introduction from 2010 of mass vaccination with a monovalent meningococcal A conjugate vaccine, serogroup A epidemics have been eliminated. Starting in 2013, the northwestern part of Nigeria has been affected by yearly outbreaks of meningitis caused by a novel strain of serogroup C Neisseria meningitidis (NmC)...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29730518/prevalence-of-gbs-serotype-iii-and-identification-of-a-st-17-like-genotype-from-neonates-with-invasive-diseases-in-guangzhou-china
#10
Junyan Liu, Ruiru Xu, Huamin Zhong, Yukui Zhong, Yongqiang Xie, Lin Li, Bing Li, Dingqiang Chen, Zhenbo Xu
OBJECTIVES: The aim of this study is to understand the surveillance of Streptococcus agalactiae (GBS) serotype and genotype which help developing specific vaccine for GBS infection. METHODS: The GBS serotype was determined by strep-B-Latex rapid agglutination method and multiplex PCR assay based on the differences among serotypes. Alleles and multilocus sequence types (MLST) were determined using the GBS MLST Web site. RESULTS: Four GBS serotypes (Ia, Ib, III, and V) were identified, with serotype III which was intimately associated with purulent meningitis and sepsis, as the dominance...
May 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29716663/organization-or-community-based-outbreak-responding-to-cases-of-meningitis-under-epidemiologic-uncertainty
#11
Tea Burmaz, Vittorio Selle, Vincenzo Baldo, Elena Savoia
Six cases of serogroup C invasive meningococcal disease were identified in Treviso district, Veneto region, Italy between December 13 and 15, 2007. The afflicted patients were found to have attended the same Latin-dance clubs on the same nights, and chemoprophylaxis was provided to potentially exposed individuals. Despite these efforts, 2 cases caused by the same meningococcal strain subsequently occurred in the same area, without any apparent epidemiological correlation to the initial cases. This may have resulted from a failure to neutralize the meningococcal carrier/s...
May 2, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29702265/cost-of-managing-meningitis-and-encephalitis-among-adult-patients-in-the-united-states
#12
J M Balada-Llasat, Ning Rosenthal, Rodrigo Hasbun, Louise Zimmer, Christine C Ginocchio, Steven Duff, Jessica Chung, Samuel Bozzette
OBJECTIVES: To determine the associated cost related to diagnosis and treatment of meningoencephalitis (ME) in adult patients in the United States. METHODS: A retrospective observational study design was used to assess the use and costs of diagnostic tests, antimicrobial treatment and total hospitalization for adult patients with suspected ME who received a lumbar puncture (LP) procedure during an emergency department visit or during the first two service days of an inpatient stay...
April 24, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29701628/seroprevalence-survey-of-arboviruses-in-workers-from-tuscany-italy
#13
Maria Elena Remoli, Cristiano Fiorentini, Antonella Marchi, Simona Di Renzi, Nicoletta Vonesch, Maria Vittoria Peri, Lucia Bastianini, Silvia Rossi, Giulia Bartoccini, Maya Lissa Kuttappasery, Maria Grazia Ciufolini, Paola Tomao
BACKGROUND: Arthropod-borne viruses (Arbovirus) play an important role among emerging and re-emerging infectious diseases and in the spreading of infections in new geographic areas. Although some arboviral infections may be asymptomatic or mild flu-like illnesses, many occur as severe forms of meningitis and meningoencephalitis. OBJECTIVES: To assess whether arboviral infections may be associated with occupational risk, in a population of agricultural and forestry workers potentially at high risk for arthropods bite and sting...
January 30, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29686150/evaluation-of-amphotericin-b-lipid-formulations-for-treatment-of-severe-coccidioidomycosis
#14
Ritam Sidhu, David B Lash, Arash Heidari, Piruthiviraj Natarajan, Royce H Johnson
BACKGROUND: Patients with severe coccidioidomycosis infections are often treated with either amphotericin-B lipid complex (ABLC) or liposomal amphotericin-B (L-AmB). Outcomes data with these agents in severe coccidioidomycosis are currently lacking. The purpose of this study is to evaluate the efficacy and toxicity of ABLC and L-AmB in treating severe coccidioidomycosis. METHODS: A retrospective, pre-post study design was employed. Chart reviews were completed from 01/01/2005 to 12/31/2014 for all patients who received lipid-based amphotericin B...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29678699/acute-communicating-hydrocephalus-as-spinal-cord-surgery-complication-in-a-patient-with-lumbar-lipomyelocele-case-report
#15
Alessandro Prior, Mariasavina Severino, Andrea Rossi, Marco Pavanello, Gianluca Piatelli, Alessandro Consales
BACKGROUND: A lumbar lipomyelocele is a closed spinal dysraphism that can cause tethered cord syndrome. Between 5-15% of spinal dysraphism surgery cases are burdened with complications, the most common being wound infections or dehiscence and cerebrospinal fluid leak. Acute communicating hydrocephalus has never been described as a complication of this type of surgery. CASE DESCRIPTION: A 6-year-old girl, who had undergone several surgeries in another Institution for lumbar lipomyeloschisis, came to our attention for a second opinion about the management of her spinal dysraphism...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29668140/-standardization-of-a-multiplex-real-time-pcr-test-for-the-identification-of-angiostrongylus-cantonensis-a-costaricensis-and-a-vasorum
#16
Rubén E Varela-M, Jinney Stefany Arias, Luz Elena Velásquez
INTRODUCTION: Angiostrongyliasis is a disease caused by Angiostrongylus nematodes that is present worldwide. The infections with the highest impact on human and animal health are caused by A. cantonensis, A. costaricensis, and A. vasorum. Clinical forms of the disease in humans are eosinophilic meningitis and abdominal angiostrongyliasis, while the most common effect on dogs are cardiopulmonary damages. It is deemed as an emerging disease as the result of the global dissemination of the African snail Lissachatina fulica, an intermediary host of these parasites...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29664700/rickettsia-helvetica-in-human-parasitizing-and-free-living-ixodes-ricinus-from-urban-and-wild-green-areas-in-the-metropolitan-city-of-rome-italy
#17
Manuela Scarpulla, Giulia Barlozzari, Laura Salvato, Claudio De Liberato, Raniero Lorenzetti, Gladia Macrì
Rickettsia helvetica is an emerging human pathogen, belonging to the spotted fever group (SFG) rickettsiae, associated with generally aneruptive fever, meningitis, and sudden death in chronic perimyocarditis. In this study, we describe the detection of R. helvetica in human-parasitizing and free-living Ixodes ricinus from the Metropolitan City of Rome. The pathogen was found in a tick acquired by a woman in an urban park. The circulation of R. helvetica was further confirmed by its detection in free-living ticks from a wild green area...
April 17, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29655501/acute-streptococcal-meningitis-presenting-as-bilateral-conductive-hearing-loss
#18
Matthew J Dougherty, Austin T Smith
Bacterial meningitis is a relatively uncommon condition encountered in the emergency department and the constellation of symptoms varies. Hearing loss has been well documented in the literature as a complication of the disease process, but not as the presenting complaint. We describe a case of a 59-year-old female who presented to the emergency department with sudden onset bilateral hearing loss who was found to have S. pneumonia meningitis bacterial meningitis. Even with advances in therapy, bacterial meningitis still carries a significant mortality rate...
April 5, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29650033/enterovirus-serotypes-in-patients-with-central-nervous-system-and-respiratory-infections-in-viet-nam-1997-2010
#19
Nguyen Thi Thuy Chinh B'Krong, Ngo Ngoc Quang Minh, Phan Tu Qui, Tran Thi Hong Chau, Ho Dang Trung Nghia, Lien Anh Ha Do, Nguyen Ngoc Nhung, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan, H Rogier van Doorn, Tran Tan Thanh
BACKGROUND: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. METHODS: Data and specimens from prospective observational clinical studies conducted between 1997 and 2010 were used...
April 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29644546/imaging-of-urgencies-and-emergencies-in-the-lung-cancer-patient
#20
REVIEW
Bruno De Potter, Jef Huyskens, Birgitta Hiddinga, Maarten Spinhoven, Annelies Janssens, Jan P van Meerbeeck, Paul M Parizel, Annemie Snoeckx
Lung cancer patients often experience potentially life-threatening medical urgencies and emergencies, which may be a direct or indirect result of the underlying malignancy. This pictorial review addresses the most common thoracic, neurological and musculoskeletal medical emergencies in lung cancer patients, including superior vena cava syndrome, pulmonary embolism, spontaneous pneumothorax, cardiac tamponade, massive haemoptysis, central airway obstruction, oesophagorespiratory fistula, malignant spinal cord compression, carcinomatous meningitis, cerebral herniation and pathological fracture...
April 11, 2018: Insights Into Imaging
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