Mythily Ganapathi, Leticia S Matsuoka, Michael March, Dong Li, Elly Brokamp, Sara Benito-Sanz, Susan M White, Katherine Lachlan, Priyanka Ahimaz, Anshuman Sewda, Lisa Bastarache, Amanda Thomas-Wilson, Joan M Stoler, Nuria C Bramswig, Julia Baptista, Karen Stals, Florence Demurger, Benjamin Cogne, Bertrand Isidor, Maria Francesca Bedeschi, Angela Peron, Jeanne Amiel, Elaine Zackai, John P Schacht, Alejandro D Iglesias, Jenny Morton, Ariane Schmetz, Verónica Seidel, Stephanie Lucia, Stephanie M Baskin, Isabelle Thiffault, Joy D Cogan, Christopher T Gordon, Wendy K Chung, Sarah Bowdin, Elizabeth Bhoj
Nuclear receptor subfamily 2 group F member 2 (NR2F2 or COUP-TF2) encodes a transcription factor which is expressed at high levels during mammalian development. Rare heterozygous Mendelian variants in NR2F2 were initially identified in individuals with congenital heart disease (CHD), then subsequently in cohorts of congenital diaphragmatic hernia (CDH) and 46,XX ovotesticular disorders/differences of sexual development (DSD); however, the phenotypic spectrum associated with pathogenic variants in NR2F2 remains poorly characterized...
October 2023: European Journal of Human Genetics: EJHG