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Felipe Fantuzzi, Benedikt Rudek, Wania Wolff, Marco Antonio Chaer Nascimento
In free-radical halogenation of aromatics singly-charged ions are usually formed as intermediates. These stable species can be easily observed by time-of-flight mass spectrometry (TOF-MS). Here we used electron and proton beams to ionize chlorobenzene (C6 H5Cl) and investigate the ions stability by TOF-MS. Additionally to the singly-charged parent ion and its fragments we find a significant yield of doubly- and triply- charged parentions not previously reported. In order to characterize these species we used high-level theoretical methods based on Density Functional Theory (DFT), Coupled-Cluster (CC)and Generalized Valence Bond (GVB) to calculate the structure, relative stabilities, and bonding of these dications and trications...
March 12, 2018: Journal of the American Chemical Society
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection. A plethora of studies show that homo- and heterodimers or even higher order oligomers of the chemokine receptors CXCR4, CCR5, and CCR2 modulate receptor function. In addition, membrane cholesterol affects chemokine receptor activity. However, structural information about homo- and heterodimers formed by chemokine receptors and their interplay with cholesterol is limited...
March 12, 2018: PLoS Computational Biology
Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, Bengt Kristian Haller, Jari Häkkinen, Ingrid J G Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras
Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previously unappreciated role for CAFs as determinants of the molecular subtype of breast cancer. We identified paracrine crosstalk between cancer cells expressing platelet-derived growth factor (PDGF)-CC and CAFs expressing the cognate receptors in human basal-like mammary carcinomas...
March 12, 2018: Nature Medicine
Nynke J van den Hoogen, Jacob Patijn, Dick Tibboel, Bert A Joosten, Maria Fitzgerald, Charlie Ht Kwok
Noxious stimulation at critical stages of development has long-term consequences on somatosensory processing in later life, but it is not known whether this developmental plasticity is restricted to nociceptive pathways. Here we investigate the effect of repeated neonatal noxious or innocuous hind-paw stimulation upon adult spinal dorsal horn cutaneous mechanical sensitivity. Neonatal Sprague-Dawley rats of both sexes received four unilateral left hind-paw needle pricks (NP, n=13) or four tactile (cotton swab touch) stimuli, per day (TC, n=11) for the first 7 days of life...
March 8, 2018: Pain
Sangeeta Taneja, Amarnath Jena, Rajesh Taneja, Aru Singh, Aashim Ahuja
OBJECTIVE: The purpose of this study is to assess whether temporal changes in68 Ga-prostate-specific membrane antigen (PSMA)-HBED-CC uptake and multiparametric MRI parameters derived using PET/MRI can aid in characterization of benign and malignant prostate lesions. MATERIALS AND METHODS: Thirty-five men with 29 malignant and six benign prostate lesions undergoing complete clinical workup including histologic analysis were enrolled for this retrospective study. All had undergone simultaneous whole-body68 Ga-PSMAHBED-CC PET/MRI...
March 12, 2018: AJR. American Journal of Roentgenology
Li Wang, Shihong Lin
Membrane capacitive deionization (MCDI) can be typically operated with constant voltage (CV) or constant current (CC) mode in the charging stage. While a series of previous studies have compared both charging modes to identify the better operating mode, neither their performance evaluation protocols were consistent, nor their conclusions unanimously converged. This study presents a new framework to evaluate and compare MCDI performance, considering the kinetic efficiency, the energetic efficiency, and the intrinsic tradeoff between the two...
March 12, 2018: Environmental Science & Technology
Kenji Takahashi, Kyohei Miyake, Shojiro Hishiyama, Naofumi Kamimura, Eiji Masai
Sphingobium sp. strain SYK-6 is able to use a phenylcoumaran-type biaryl, dehydrodiconiferyl alcohol (DCA), as a sole source of carbon and energy. In SYK-6 cells, the alcohol group of the B-ring side chain of DCA was first oxidized to the carboxyl group, and then the alcohol group of the A-ring side chain was oxidized to generate 5-(2-carboxyvinyl)-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate (DCA-CC). We identified phcF, phcG, and phcH, which conferred the ability to convert DCA-CC into 3-(4-hydroxy-3-(4-hydroxy-3-methoxystyryl)-5-methoxyphenyl)acrylate (DCA-S) in a host strain...
March 12, 2018: Environmental Microbiology
Gudla Sruthi, M Mansoor Ahammed, Abhipsa R Makwana
Bacterial removal during electrocoagulation (EC) was investigated employing samples from four different water/wastewater sources, namely, greywater, river water, secondary treated sewage and tap water spiked with Escherichia coli. Effects of current density and electrolysis time on the bacterial removal with aluminium electrodes were evaluated. For greywater, river water and secondary treated sewage, total coliform and E. coli removal efficiencies were not significantly different for the tested samples and varied in the range of 2...
March 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Devin B Phillips, Craig D Steinback, Sophie É Collins, Desi P Fuhr, Tracey L Bryan, Eric Y L Wong, Vincent Tedjasaputra, Mohit Bhutani, Michael K Stickland
COPD patients have increased central arterial stiffness and muscle sympathetic nervous activity (MSNA), both of which contribute to cardiovascular (CV) dysfunction and increased CV risk. Previous work suggests that COPD patients have elevated carotid chemoreceptor (CC) activity/sensitivity, which may contribute to the elevated MSNA and arterial stiffness. Accordingly, the effect of CC inhibition on central arterial stiffness, MSNA and CV function at rest in COPD patients was examined in a randomized placebo-controlled study...
March 12, 2018: Journal of Physiology
D Mihrin, P W Jakobsen, A Voute, L Manceron, R Wugt Larsen
The high-resolution terahertz absorption spectrum of the large-amplitude intermolecular donor librational band ν of the homodimer (HCN)2 has been recorded by means of long-path static gas-phase Fourier transform spectroscopy at 207 K employing a highly brilliant electron storage ring source. The rovibrational structure of the ν band has the typical appearance of a perpendicular type band of a Σ-Π transition for a linear polyatomic molecule. The generated terahertz spectrum is analyzed employing a standard semi-rigid linear molecule Hamiltonian, yielding a band origin ν0 of 119...
March 12, 2018: Physical Chemistry Chemical Physics: PCCP
Jin-Xin Zheng, Zhi-Wei Lin, Chen Chen, Zhong Chen, Fo-Jun Lin, Yang Wu, Si-Yu Yang, Xiang Sun, Wei-Ming Yao, Duo-Yun Li, Zhi-Jian Yu, Jia-Lin Jin, Di Qu, Qi-Wen Deng
Klebsiella pneumoniae bacteremia biofilm traits and distribution characteristics have not been clarified. This study aimed to determine the prevalence and characteristics of K. pneumoniae bacteremia biofilm formation (BF) and to explore the virulence factors associated with K. pneumoniae BF. A total of 250 K. pneumoniae bacteremia isolates were collected from patients in Shenzhen and Shanghai, China. Virulence genes in their genomes were detected by PCR. The isolates were subjected to multilocus sequence typing (MLST) and clonal complex (CC) classification based on housekeeping genes...
2018: Frontiers in Cellular and Infection Microbiology
Stefania Evangelisti, Claudia Testa, Lorenzo Ferri, Laura Ludovica Gramegna, David Neil Manners, Giovanni Rizzo, Daniel Remondini, Gastone Castellani, Ilaria Naldi, Francesca Bisulli, Caterina Tonon, Paolo Tinuper, Raffaele Lodi
Objectives: To evaluate functional connectivity (FC) in patients with sleep-related hypermotor epilepsy (SHE) compared to healthy controls. Methods: Resting state fMRI was performed in 13 patients with a clinical diagnosis of SHE (age = 38.3 ± 11.8 years, 6 M) and 13 matched healthy controls (age = 38.5 ± 10.8 years, 6 M).Data were first analysed using probabilistic independent component analysis (ICA), then a graph theoretical approach was applied to assess topological and organizational properties at the whole brain level...
2018: NeuroImage: Clinical
María Díez-Cirarda, Antonio P Strafella, Jinhee Kim, Javier Peña, Natalia Ojeda, Alberto Cabrera-Zubizarreta, Naroa Ibarretxe-Bilbao
The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB)...
2018: NeuroImage: Clinical
Lutz E Kraushaar, Alexander Dressel, Alexander Maßmann
Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of risk factor-challenged cohorts...
March 2018: Preventive Medicine Reports
Heather N Anderson, Frank Cetta, David J Driscoll, Timothy M Olson, Michael J Ackerman, Jonathan N Johnson
Idiopathic restrictive cardiomyopathy (IRC) is a rare condition characterized by reduced ventricular compliance. Children with IRC have poor outcomes with most patients proceeding to cardiac transplantation. We sought to analyze our institutional experience and assess contemporary outcomes for children with IRC. We reviewed the medical record for patients (<21 years old) evaluated for a primary diagnosis of IRC between 1975 and 2013 at our institution. Demographic, clinical, echocardiographic, and catheterization data were abstracted...
February 12, 2018: American Journal of Cardiology
Emi Morita, Mikio Watanabe, Naoya Inoue, Hidemi Hashimoto, Emi Haga, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are different pathological types of autoimmune thyroid diseases (AITDs). However, the epigenetic differences between these diseases have not been elucidated. DNA methylation is one of the primary epigenetic modifications that reflect environmental influences on gene expression. In this study, we evaluated the methylation status of six CpG sites in the TNFA promoter using pyrosequencing and analyzed the data in combination with functional polymorphisms (-1031 T/C and +123 C/T) in the TNFA gene to clarify the role of gene methylation on the prognosis of AITDs...
March 11, 2018: Autoimmunity
Sebastian Łaźniak, Anna Lutkowska, Żaneta Wareńczak-Florczak, Anna Sowińska, Alexander Tsibulski, Andrzej Roszak, Stefan Sajdak, Pawel P Jagodziński
PURPOSE: Previous studies have reported a significant contribution of NC_000008.10:g.128413305 G>T (rs6983267) single-nucleotide polymorphism (SNP) in the MYC enhancer region to the susceptibility of various cancers. However, the role of rs6983267 SNP in cervical cancer (CC) development and progression has not been demonstrated to date. Therefore, we evaluated the role of rs6983267 SNP in MYC expression in cervical cancers and non-cancerous cervical tissues. In addition, we assessed the role of this SNP in the development and progression of CC...
March 10, 2018: Archives of Gynecology and Obstetrics
Faraz Farhadi, Moozhan Nikpanah, Xiaobai Li, Rolf Symons, Amir Pourmorteza, Maria J Merino, W Marston Linehan, Ashkan A Malayeri
PURPOSE: To determine whether the type of VHL gene pathogenic variant influences the growth rate or CT enhancement values of renal lesions in VHL patients. MATERIALS AND METHODS: Thirty-two VHL patients (19 male) were selected from a prospectively maintained imaging database for patients that underwent surgical tumor resection between 2014 and 2016. One hundred and eleven VHL lesions were marked for resection and pathology analysis. Whole lesion volumetric segmentation was performed on nephrographic phase of the two most recent contrast-enhanced CT scans before surgery...
March 10, 2018: Abdominal Radiology
Thomas Brun, Jean-Marc Bachaud, Pierre Graff-Cailleaud, Bernard Malavaud, Daniel Portalez, Christian Popotte, Richard Aziza, Amélie Lusque, Thomas Filleron, Soléakhéna Ken
PURPOSE: To present the feasibility study of optimal dose coverage in ultra-focal brachytherapy (UFB) with multiparametric MRI for low- and intermediate-risk prostate cancer. METHODS AND MATERIALS: UFB provisional dose plans for small target volumes (<7 cc) were calculated on a prostate training phantom to optimize the seeds number and strength. Clinical UFB consisted in a contour-based nonrigid registration (MRI/Ultrasound) to implant a fiducial marker at the location of the tumor focus...
March 7, 2018: Brachytherapy
Yuanshan Liu, Zitong Huang, Heng Li, Guanghui Zheng, Qin Ling, Wanchun Tang, Zhengfei Yang
PURPOSE: We investigated the effects of a cardiopulmonary resuscitation (CPR) feedback/prompt device on the quality of chest compression (CC) during hands-only CPR following the 2015 AHA guidelines. METHODS: A total of 124 laypersons were randomly assigned into three groups. The first (n=42) followed the 2010 guidelines, the second (n=42) followed the 2015 guidelines with no feedback/prompt device, the third (n=40) followed the 2015 guidelines with a feedback/prompt device (2015F)...
March 6, 2018: American Journal of Emergency Medicine
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