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https://www.readbyqxmd.com/read/29351705/percutaneous-endoscopic-rendezvous-procedure-for-the-management-of-bile-duct-injuries-after-cholecystectomy-short-and-long-term-outcomes
#1
Anne Marthe Schreuder, Klaske A C Booij, Philip R de Reuver, Otto M van Delden, Krijn P van Lienden, Marc G Besselink, Olivier R Busch, Dirk J Gouma, Erik A J Rauws, Thomas M van Gulik
BACKGROUND:  Bile duct injury (BDI) remains a daunting complication of laparoscopic cholecystectomy. In patients with complex BDI, a percutaneous-endoscopic rendezvous procedure may be required to establish bile duct continuity. The aim of this study was to assess short- and long-term outcomes of the rendezvous procedure. METHODS:  All consecutive patients with BDI referred to our tertiary referral center between 1995 and 2016 were analyzed. A rendezvous procedure was performed when endoscopic or radiologic intervention failed, and when deemed feasible by a dedicated multidisciplinary team including hepatopancreaticobiliary surgeons, gastrointestinal endoscopists, and interventional radiologists...
January 19, 2018: Endoscopy
https://www.readbyqxmd.com/read/29351662/the-versatile-tanycyte-a-hypothalamic-integrator-of-reproduction-and-energy-metabolism
#2
Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
The fertility and survival of an individual rely on the ability of the periphery to promptly, effectively and reproducibly communicate with brain neural networks that control reproduction, food intake and energy homeostasis. Tanycytes, a specialized glial cell type lining the wall of the third ventricle in the median eminence of the hypothalamus, appear to act as the linchpin of these processes by dynamically controlling the secretion of neuropeptides into the portal vasculature by hypothalamic neurons and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on the ability of these cells to adapt their morphology to the physiological state of the individual...
January 17, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29351619/repairing-folding-defective-%C3%AE-sarcoglycan-mutants-by-cftr-correctors-a-potential-therapy-for-limb-girdle-muscular-dystrophy-2d
#3
Marcello Carotti, Justine Marsolier, Michela Soardi, Elisa Bianchini, Chiara Gomiero, Chiara Fecchio, Sara F Henriques, Romeo Betto, Roberta Sacchetto, Isabelle Richard, Dorianna Sandonà
Limb Girdle Muscular Dystrophy type 2D (LGMD2D) is a rare autosomal-recessive disease, affecting striated muscle, due to mutation of SGCA, the gene coding for α-sarcoglycan. Nowadays more than 50 different SGCA missense mutations have been reported. They are supposed to impact folding and trafficking of α-sarcoglycan because the defective polypeptide, although potentially functional, is recognized and disposed of by the quality control of the cell. The secondary reduction of α-sarcoglycan partners, β-, γ- and δ-sarcoglycan, disrupts a key membrane complex that, associated to dystrophin, contributes to assure sarcolemma stability during muscle contraction...
January 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29351614/a-membrane-g-protein-coupled-estrogen-receptor-is-necessary-but-not-sufficient-for-sex-differences-in-zebra-finch-auditory-coding
#4
Amanda A Krentzel, Matheus Macedo-Lima, Maaya Z Ikeda, Luke Remage-Healey
Estradiol acts as a neuromodulator in brain regions important for cognition and sensory processing. Estradiol also shapes brain sex differences, but rarely have these concepts been considered simultaneously. In male and female songbirds, estradiol rapidly increases within the auditory forebrain during song exposure and enhances local auditory processing. We tested whether GPER1, a membrane bound estrogen receptor, is necessary and sufficient for neuroestrogen regulation of forebrain auditory processing in male and female zebra finches (Taeniopygia guttata)...
January 17, 2018: Endocrinology
https://www.readbyqxmd.com/read/29351584/the-roles-of-left-versus-right-anterior-temporal-lobes-in-semantic-memory-a-neuropsychological-comparison-of-postsurgical-temporal-lobe-epilepsy-patients
#5
Grace E Rice, Helen Caswell, Perry Moore, Paul Hoffman, Matthew A Lambon Ralph
The presence and degree of specialization between the anterior temporal lobes (ATLs) is a key issue in debates about the neural architecture of semantic memory. Here, we comprehensively assessed multiple aspects of semantic cognition in a large group of postsurgical temporal lobe epilepsy (TLE) patients with left versus right anterior temporal lobectomy (n = 40). Both subgroups showed deficits in expressive and receptive verbal semantic tasks, word and object recognition, naming and recognition of famous faces and perception of faces and emotions...
January 17, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29351571/the-barriers-and-facilitators-for-recognising-distress-in-people-with-severe-dementia-on-general-hospital-wards
#6
G J E Crowther, C A Brennan, M I Bennett
Introduction: psychological symptoms and delirium are common, but underreported in people with dementia on hospital wards. Unrecognised and untreated symptoms can manifest as distress. Identifying distress accurately therefore could act as a trigger for better investigation and treatment of the underlying causes. The challenges faced by healthcare professionals to recognise and report distress are poorly understood. Methods: semi-structured interviews with a purposive sample of 25 healthcare professionals working with older people in general hospitals were conducted...
January 17, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29351564/steatosis-in-south-african-women-how-much-and-why
#7
Nitien H Naran, Mark Haagensen, Nigel J Crowther
BACKGROUND: Globally, steatosis is the commonest type of liver pathology and is closely associated with obesity and the metabolic syndrome. Obesity is common in urban African females but no data is available on hepatic fat content in this population group when compared to other ethnic groups. The aim of this study was therefore to compare hepatic fat content in woman from different ethnic groups in South Africa and to characterise the principle determinants of liver fat. MATERIALS AND METHODS: A convenience sample of 106 (48 Indian, 29 African and 29 Caucasian) female volunteers aged 20-60 years and having no history of cardiometabolic disorders were recruited...
2018: PloS One
https://www.readbyqxmd.com/read/29351514/the-ace2-angiotensin-1-7-mas-axis-of-the-renin-angiotensin-system-focus-on-angiotensin-1-7
#8
Robson Augusto Souza Santos, Walkyria Oliveira Sampaio, Andreia C Alzamora, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Maria Jose Campagnole-Santos
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The classical view of this system saw it as a sequence of many enzymatic steps that culminate in the production of a single biologically active metabolite, the octapeptide angiotensin (ANG) II, by the angiotensin converting enzyme (ACE). The past two decades have revealed new functions for some of the intermediate products, beyond their roles as substrates along the classical route...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29351512/physiology-of-astroglia
#9
Alexei Verkhratsky, Maiken Nedergaard
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in morphological appearance; they express a multitude of receptors, channels, and membrane transporters. This complement underlies their remarkable adaptive plasticity that defines the functional maintenance of the CNS in development and aging. Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29351507/-i-smoke-like-this-to-suppress-these-issues-that-are-flaws-of-my-character-challenges-and-facilitators-of-cessation-among-smokers-with-bipolar-disorder
#10
Jaimee L Heffner, Noreen L Watson, Jennifer B McClure, Robert M Anthenelli, Sarah Hohl, Jonathan B Bricker
OBJECTIVE: Smokers with bipolar disorder (BD) have low rates of successful quitting, yet no prior studies have evaluated the process of quitting among these smokers in the context of a current quit attempt. To facilitate development of more effective interventions, we conducted a qualitative exploration of challenges and facilitators of quitting in an intervention study for smokers with BD. METHODS: Participants were adult daily smokers with BD (n = 10) who completed a 10-week smoking cessation intervention consisting of Acceptance and Commitment Therapy (ACT) and nicotine patch...
January 19, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29351486/different-physiological-roles-of-insulin-receptors-in-mediating-nutrient-metabolism-in-zebrafish
#11
Bin-Yuan Yang, Gang Zhai, Yu-Long Gong, Jing-Zhi Su, Xu-Yan Peng, Guo-Hui Shang, Dong Han, Jun-Yan Jin, Hao-Kun Liu, Zhen-Yu Du, Zhan Yin, Shou-Qi Xie
Insulin, the most potent anabolic hormone, is critical for somatic growth and metabolism in vertebrates. Type 2 diabetes, which is the primary cause of hyperglycemia, results from an inability of insulin to signal glycolysis and gluconeogenesis. Our previous study showed that double knockout of insulin receptor a (insra) and b (insrb) caused β-cell hyperplasia and lethality from 5 dpf to 16 dpf. In this study, we characterized the physiological roles of Insra and Insrb, in somatic growth and fueling metabolism, respectively...
December 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351452/the-role-of-intracellular-angiotensin-ii
#12
Richard N Re
It has become clear that the vasoactive peptide angiotensin II, like other so-called intracrines, can act in the intracellular space. Evidence has accumulated indicating that such angiotensin II activity can be upregulated in disease states and cause pathology. Indeed, other intracrines appear to be involved in disease pathogenesis as well. At the same time nitric oxide, potentially a cell protective factor, has been shown to be upregulated by intracellular angiotensin II. Recently data has been developed indicating that other potentially protective factors are directly upregulated at neuronal nuclei by angiotensin II...
January 12, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351420/fourth-ventricular-tsh-induces-satiety-and-increases-body-temperature-in-rats
#13
Ulrika Smedh, Karen A Scott, Timothy H Moran
Besides its well-known action to stimulate thyroid hormone release, Thyrotropin mRNA is expressed within the brain and Thyrotropin and its receptor have been shown to be present in brain areas that control feeding and gastrointestinal function. Here, the hypothesis that Thyrotropin acts on receptors in the dorsal hindbrain to alter food intake and/or gastric function was tested. Fourth ventricular injections of Thyrotropin (0.06, 0.6 and 6.0 µg) were given to rats with chronic intracerebroventricular cannulas aimed at the fourth ventricle...
January 3, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351414/the-murine-choroid-plexus-epithelium-expresses-the-2cl-h-exchanger-clc-7-and-na-h-exchanger-nhe6-in-the-luminal-membrane-domain
#14
Helle H Damkier, Henriette L Christensen, Inga B Christensen, Qi Wu, Robert A Fenton, Jeppe Praetorius
The choroid plexus epithelium within the brain ventricles secretes the majority of the cerebrospinal fluid (CSF). The luminal Na+,K+-ATPase acts in concert with a host of other transport proteins to mediate efficient fluid secretion across the epithelium. The CSF contains little protein buffer, but the pH value seems nonetheless maintained within narrow limits, even when faced with acid/base challenges. The involvement of choroid plexus acid/base transporters in CSF pH regulation is highlighted by the expression of several acid/base transporters in the epithelium...
December 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351412/expression-of-ctgf-ccn2-in-response-to-lpa-is-stimulated-by-fibrotic-extracellular-matrix-via-the-integrin-fak-axis
#15
Camilo Riquelme-Guzman, Osvaldo Contreras, Enrique Brandan
Fibrosis is a common feature of several chronic diseases, and is characterized by exacerbated accumulation of extracellular matrix (ECM). Understanding the cellular and molecular mechanisms involved in the development of this condition is crucial for designing efficient treatments for those pathologies. Connective tissue growth factor (CTGF/CCN2) is a pleiotropic protein with strong pro-fibrotic activity. In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA)...
December 27, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351393/liver-tissue-metabolically-transformed-by-alcohol-induces-immune-recognition-of-liver-self-proteins-but-not-in-vivo-inflammation
#16
Michael J Duryee, Benjamin M Wiese, Jordan R Bowman, Jared D Vanlandingham, Lynell W Klassen, Geoffrey E Thiele, Carlos D Hunter, Daniel R Anderson, Ted R Mikuls, Geoffrey M Thiele
Precision cut liver slices (PCLSs) provide a novel model for studies in alcoholic liver disease (ALD). This is relevant, as in vivo ethanol exposure does not appear to generate significant liver damage in ethanol fed mice, except in the NIAAA binge model of ALD. Previous studies have shown that the two metabolites of ethanol consumption, malondialdhyde (MDA) and acetaldehyde (AA), combine to form (MAA), which has been correlated with the development and progression of ALD. In this study murine PCLSs were incubated with ethanol and examined for the production of MAA...
December 28, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29351290/land-use-change-in-oil-palm-dominated-tropical-landscapes-an-agent-based-model-to-explore-ecological-and-socio-economic-trade-offs
#17
Claudia Dislich, Elisabeth Hettig, Jan Salecker, Johannes Heinonen, Jann Lay, Katrin M Meyer, Kerstin Wiegand, Suria Tarigan
Land-use changes have dramatically transformed tropical landscapes. We describe an ecological-economic land-use change model as an integrated, exploratory tool used to analyze how tropical land-use change affects ecological and socio-economic functions. The model analysis seeks to determine what kind of landscape mosaic can improve the ensemble of ecosystem functioning, biodiversity, and economic benefit based on the synergies and trade-offs that we have to account for. More specifically, (1) how do specific ecosystem functions, such as carbon storage, and economic functions, such as household consumption, relate to each other? (2) How do external factors, such as the output prices of crops, affect these relationships? (3) How do these relationships change when production inefficiency differs between smallholder farmers and learning is incorporated? We initialize the ecological-economic model with artificially generated land-use maps parameterized to our study region...
2018: PloS One
https://www.readbyqxmd.com/read/29351289/the-rumour-spectrum
#18
Nicolas Turenne
Rumour is an old social phenomenon used in politics and other public spaces. It has been studied for only hundred years by sociologists and psychologists by qualitative means. Social media platforms open new opportunities to improve quantitative analyses. We scanned all scientific literature to find relevant features. We made a quantitative screening of some specific rumours (in French and in English). Firstly, we identified some sources of information to find them. Secondly, we compiled different reference, rumouring and event datasets...
2018: PloS One
https://www.readbyqxmd.com/read/29351274/dna-polymerase-iv-primarily-operates-outside-of-dna-replication-forks-in-escherichia-coli
#19
Sarah S Henrikus, Elizabeth A Wood, John P McDonald, Michael M Cox, Roger Woodgate, Myron F Goodman, Antoine M van Oijen, Andrew Robinson
In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in motion a series of different DNA repair and damage tolerance pathways. DNA polymerase IV (pol IV) is one of three specialised DNA polymerases called into action during the SOS response to help cells tolerate certain types of DNA damage. The canonical view in the field is that pol IV primarily acts at replisomes that have stalled on the damaged DNA template. However, the results of several studies indicate that pol IV also acts on other substrates, including single-stranded DNA gaps left behind replisomes that re-initiate replication downstream of a lesion, stalled transcription complexes and recombination intermediates...
January 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29351231/molecular-network-based-identification-of-competing-endogenous-rnas-in-thyroid-carcinoma
#20
Minjia Lu, Xingyu Xu, Baohang Xi, Qi Dai, Chenli Li, Li Su, Xiaonan Zhou, Min Tang, Yuhua Yao, Jialiang Yang
RNAs may act as competing endogenous RNAs (ceRNAs), a critical mechanism in determining gene expression regulations in many cancers. However, the roles of ceRNAs in thyroid carcinoma remains elusive. In this study, we have developed a novel pipeline called Molecular Network-based Identification of ceRNA (MNIceRNA) to identify ceRNAs in thyroid carcinoma. MNIceRNA first constructs micro RNA (miRNA)-messenger RNA (mRNA)long non-coding RNA (lncRNA) networks from miRcode database and weighted correlation network analysis (WGCNA), based on which to identify key drivers of differentially expressed RNAs between normal and tumor samples...
January 19, 2018: Genes
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