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https://www.readbyqxmd.com/read/29050886/disparities-in-access-to-emergency-general-surgery-care-in-the-united-states
#1
Jasmine A Khubchandani, Connie Shen, Didem Ayturk, Catarina I Kiefe, Heena P Santry
BACKGROUND: As fewer surgeons take emergency general surgery call and hospitals decrease emergency services, a crisis in access looms in the United States. We examined national emergency general surgery capacity and county-level determinants of access to emergency general surgery care with special attention to disparities. METHODS: To identify potential emergency general surgery hospitals, we queried the database of the American Hospital Association for "acute care general hospital," with "surgical services," and "emergency department," and ≥1 "operating room...
October 16, 2017: Surgery
https://www.readbyqxmd.com/read/29048269/an-improved-collagen-zymography-approach-for-evaluating-the-collagenases-mmp-1-mmp-8-and-mmp-13
#2
Seniz Inanc, Didem Keles, Gulgun Oktay
Collagen zymography is an SDS-PAGE-based method for detecting both the proenzyme and active forms of collagenases. Although collagen zymography is used for assessment of the matrix metalloproteinases MMP-1 and MMP-13, it can be difficult to detect these collagenases due to technical issues. Moreover, it remains unclear whether the collagenase activity of MMP-8 can be detected by this method. Here, we present an improved collagen zymography method that allows quantification of the activities of MMP-1, MMP-8, and MMP-13...
October 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29029989/the-effect-of-demographic-and-disease-variables-on-schneiderian-membrane-thickness-and-appearance
#3
Tuba Talo Yildirim, Güliz Nigar Güncü, Dincer Göksülük, Melek Didem Tözüm, Mehmet Colak, Tolga Fikret Tözüm
OBJECTIVES: The purpose of this study was to evaluate the prevalence of sinus mucosal thickening (MT) and mucosal appearance (MA) in a patient population as detected with cone beam computed tomography (CBCT) and to determine the effects of various disease and demographic factors on MT and MA. STUDY DESIGN: The retrospective study consisted of CBCT images of 1000 maxillary arches in 500 patients. The arches were divided into 3 groups (atrophic, partially atrophic, and nonatrophic) according to the type of the maxillary dental crest...
September 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29017000/visual-and-postural-motion-evoked-dizziness-symptoms-are-predominant-in-vestibular-migraine-patients
#4
Doga Vuralli, Funuzar Yildirim, Didem T Akcali, Mustafa N Ilhan, Nebil Goksu, Hayrunnisa Bolay
Background: Vestibular migraine (VM) is one of the most common underdiagnosed disorders. We aimed to study the clinical characteristics of VM patients who were referred to a neurology-headache unit by otolaryngology after exclusion of peripheral causes of vertigo. Methods: One hundred and one patients diagnosed with VM in the headache unit were included. Description of vestibular symptoms, demographic and clinical features, trigger factors, accompanying diseases, and response to vestibular-suppressant medications and prophylactic migraine treatment were evaluated...
July 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28994226/proteinuria-in-pediatric-renal-transplant-recipients
#5
Songül Yılmaz, Z Birsin Özçakar, Aysel Taktak, Eda Didem Kurt-Şükür, Nilgün Çakar, Fatoş Yalçınkaya
Proteinuria has been shown to be an important and potentially treatable risk factor for graft loss. The aim of this study was to evaluate prevalence, etiology, and outcome of proteinuria during the follow-up of children with renal transplantation. We retrospectively reviewed the files of renal transplanted children between 2006 and 2016 in our center. All patients were interpreted with respect to the demographic data and clinical and laboratory features including information about proteinuria. Chi-square test and Mann-Whitney U test were used for analysis...
October 9, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28989732/investigating-the-association-between-social-interactions-and-personality-states-dynamics
#6
Didem Gundogdu, Ailbhe N Finnerty, Jacopo Staiano, Stefano Teso, Andrea Passerini, Fabio Pianesi, Bruno Lepri
The recent personality psychology literature has coined the name of personality states to refer to states having the same behavioural, affective and cognitive content (described by adjectives) as the corresponding trait, but for a shorter duration. The variability in personality states may be the reaction to specific characteristics of situations. The aim of our study is to investigate whether specific situational factors, that is, different configurations of face-to-face interactions, are predictors of variability of personality states in a work environment...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28984480/the-current-status-of-adjuvant-treatment-for-high-risk-renal-cell-carcinoma
#7
Mutlu Hızal, Mehmet An Şendur, Burak Bilgin, Muhammed Bülent Akıncı, Didem Şener Dede, Bulent Yalçın
No abstract text is available yet for this article.
October 6, 2017: Future Oncology
https://www.readbyqxmd.com/read/28984026/hypertension-and-improved-left-ventricular-mass-index-in-children-after-renal-transplantation
#8
Mehmet G Ramoğlu, Tayfun Uçar, Songül Yılmaz, Z Birsin Özçakar, Eda Didem Kurt-Şükür, Ercan Tutar, Fatoş Yalçınkaya, Semra Atalay
This study was conducted to evaluate the changes in BP and LVH after the transplantation and to evaluate the effect of BP changes in LVH. Forty-three pediatric renal transplant patients, with a mean age of 16.99 ± 3.88 years, were enrolled in this study. Twenty-three (53.5%) of the patients were male. Medical records for pretransplantation period (closest to the time of transplantation) and for post-transplantation period (9-12 months after transplantation) were reviewed. All the patients had BP measurements and echocardiographic evaluation in pre- and post-transplantation period...
October 5, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28982858/effects-of-s1p1-and-s1p3-in-er-and-er-breast-cancer-cells
#9
COMPARATIVE STUDY
Ibrahim Ugur Calis, Didem Turgut Cosan, Fezan Mutlu
BACKGROUND/AIM: In this study, sphingosine-1-phosphate receptor-1 (S1P1) and S1P3 receptors were silenced to evaluate proliferation, adhesion, viability and lateral motility in estrogen receptor-negative MCF-7 and estrogen receptor-positive MDA-MB-231 breast cancer cells. MATERIALS AND METHODS: Groups of MCF-7 and MDA-MB-231 cells with: no small interfering RNA (siRNA); siRNA with no target; S1P1-silencing siRNA; S1P3-silencing siRNA; and siRNAs silencing both S1P1, and S1P3 were examined for this purpose at 24, 48 and 72 h after intervention...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28979986/geographic-diffusion-and-implementation-of-acute-care-surgery-an-uneven-solution-to-the-national-emergency-general-surgery-crisis
#10
Jasmine A Khubchandani, Angela M Ingraham, Vijaya T Daniel, Didem Ayturk, Catarina I Kiefe, Heena P Santry
Importance: Owing to lack of adequate emergency care infrastructure and decline in general surgery workforce, the United States faces a crisis in access to emergency general surgery (EGS) care. Acute care surgery (ACS), an organized system of trauma, general surgery, and critical care, is a proposed solution; however, ACS diffusion remains poorly understood. Objective: To investigate geographic diffusion of ACS models of care and characterize the communities in which ACS implementation is lagging...
October 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28955722/the-progestin-receptor-interactome-in-the-female-mouse-hypothalamus-interactions-with-synaptic-proteins-are-isoform-specific-and-ligand-dependent
#11
Kalpana D Acharya, Sabin A Nettles, Katherine J Sellers, Dana D Im, Moriah Harling, Cassandra Pattanayak, Didem Vardar-Ulu, Cheryl F Lichti, Shixia Huang, Dean P Edwards, Deepak P Srivastava, Larry Denner, Marc J Tetel
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study, proteins from female mouse hypothalamus that associate with PR were isolated using affinity pull-down assays with glutathione S-transferase-tagged mouse PR-A and PR-B. Using complementary proteomics approaches, reverse phase protein array (RPPA) and mass spectrometry, we identified hypothalamic proteins that interact with PR in a ligand-dependent and isoform-specific manner and were confirmed by Western blot...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28954093/the-relationship-between-pruritus-and-clinical-variables-in-patients-with-psoriasis
#12
Anil Gulsel Bahali, Nahide Onsun, Ozlem Su, Dilek Biyik Ozkaya, Didem Dizman, Bugce Topukcu, Omer Uysal
Background: Pruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited. Objective: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Methods: We analyzed data of psoriatic patients diagnosed in our psoriasis outpatient clinic between March 2013 and June 2014 collected retrospectively from PSR-TR registration system...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28944943/effect-of-systemic-application-of-bone-marrow-derived-mesenchymal-stem-cells-on-healing-of-peripheral-nerve-injury-in-an-experimental-sciatic-nerve-injury-model
#13
Zahir Kizilay, Serdar Aktas, Nesibe Kahraman Cetin, Didem Bakay Ilhan, Gulfem Ersoy, Haydar Ali Erken
AIM: To investigate the effects of systemic application of bone marrow-derived mesenchymal stem cells in a compression model of peripheral nerve injury. MATERIAL AND METHODS: 24 male Wistar albino rats were randomly divided into 3 equal groups (n=8):Control (C),injury (I),and stem cell and injury (SI).The sciatic nerve of rats in the I and SI groups was subjected to clip compression for 5 minutes.Moreover,approximately 5x105 bone marrow-derived mesenchymal stem cells were given via tail vein of the rats in the SI group immediately after clip compression...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28941122/evaluation-of-periostin-and-factors-associated-with-new-bone-formation-in-ankylosing-spondylitis-periostin-may-be-associated-with-the-wnt-pathway
#14
Dilek Solmaz, Sadettin Uslu, Didem Kozacı, Neslihan Karaca, Hale Bulbul, Emine Figen Tarhan, Mustafa Ozmen, Gercek Can, Servet Akar
OBJECTIVE: Periostin has been shown to be involved in bone anabolism through the regulation of Wnt-β-catenin signaling. It may be one of the pathogenic mechanisms in syndesmophyte formation in ankylosing spondylitis (AS). The aim of this study was to evaluate serum periostin levels in patients with AS and to assess relationships among biomarkers of bone formation and periostin in disease outcomes, particularly radiographic changes. METHODS: Ninety-seven consecutive AS patients (78% male) and 48 healthy controls (75% male) were included in the study...
September 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28913144/effect-of-pigtail-catheter-application-on-obstetric-outcomes-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-pregnancies-following-hyperstimulation-syndrome
#15
Pınar Çağlar Aytaç, Hakan Kalaycı, Selçuk Yetkinel, Didem Alkaş, Seda Yüksel Şimşek, Bülent Haydardedeoğlu, Esra Bulgan Kılıçdağ
OBJECTIVE: To evaluate the effects of percutaneous pigtail catheter drainage on the outcomes of intracytoplasmic sperm injection (ICSI) pregnancies following moderate or severe ovarian hyperstimulation syndrome (OHSS). MATERIALS AND METHODS: This retrospective study included 189 patients hospitalized for OHSS following ICSI treatment in a tertiary in vitro fertilization unit between 2006 and 2014. Pigtail catheters were applied in 63 patients; the other 126 patients did not need that treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28894849/educational-study-to-increase-breast-cancer-knowledge-level-and-scanning-participation-among-women-working-at-a-university
#16
Nebahat Özerdoğan, Berrak Mızrak Şahin, Nedime Kösgeroğlu, İlkay Culha, Nese Çelik, Fatma Deniz Sayıner, Ayfer Açıkgoz, Ayşe Özkaraman, Didem Arslantaş, Setenay Öner, Mine Boyacı, Sevgi Giray, Nesrin Demirtaş, Sinan Özalp
OBJECTIVE: The aim of the study is to increase the participation level of women in screening programs by increasing the level of knowledge about early diagnosis and screening methods for breast cancer (BC). MATERIALS AND METHODS: This was a pretest-posttest one group design study held in Eskişehir Osmangazi University, Turkey. The sample consisted of 405 women in all departments of the University. Data were collected using socio-demographic forms and questionnaires...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28894759/differential-efficiency-of-transcutaneous-electrical-nerve-stimulation-in-dominant-versus-nondominant-hands-in-fibromyalgia-placebo-controlled-functional-near-infrared-spectroscopy-study
#17
Aykut Eken, Murat Kara, Bora Baskak, Ayşegül Baltacı, Didem Gökçay
Using functional near-infrared spectroscopy (fNIRS), modulation of hemodynamic responses by transcutaneous electrical nerve stimulation (TENS) during delivery of nociceptive stimulation was investigated in fibromyalgia (FM) patients and healthy controls for both hands. Two experiments were conducted: (1) median nerve stimulation with TENS and (2) painful stimulation using electronic von Frey filaments with TENS/placebo TENS. Mean [Formula: see text] brain activity was compared across groups and conditions using factorial ANOVA...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28892296/tailored-approaches-in-drug-development-and-diagnostics-from-molecular-design-to-biological-model-systems
#18
REVIEW
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M H Salo-Ahen, Ronald Österbacka, John E Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches...
September 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28890061/cerebral-protection-with-a-temporary-ascending-aorta-external-carotid-artery-bypass-during-common-carotid-artery-revascularization
#19
Murat Ugurlucan, Yilmaz Onal, Didem Melis Oztas, Cagla Canbay, Ibrahim Demir, Omer Ali Sayin, Ozgur Kilickesmez, Mehmet Semih Cakir, Kubilay Aydin, Ufuk Alpagut
Atherosclerosis is a systemic disease, and multiarterial involvement is common. Involvement of all the supra-aortic arteries may occur in the same patient making cerebral revascularization challenging. In this report, we present complete supra-aortic revascularization, that is, revascularization of the bilateral common carotid and subclavian arteries in a 51-year-old male patient with occluded brachiocephalic trunk, left subclavian artery, and proximally stenotic left common carotid artery. A temporary ascending aorta to left external carotid artery bypass provided meticulous cerebral protection with pulsatile cerebral flow in the presence of a proximal arterial clamp; hence, a neurologically uneventful procedure during bilateral common carotid artery revascularization...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28884960/genotypic-phenotypic-features-and-enzyme-replacement-therapy-outcome-in-patients-with-mucopolysaccharidosis-vi-from-turkey
#20
Mustafa Kılıç, Ali Dursun, Turgay Coşkun, Ayşegül Tokatlı, Rıza K Özgül, Didem Yücel-Yılmaz, Mehmet Karaca, Deniz Doğru, Dursun Alehan, Sibel Kadayıfçılar, Aydan Genç, Handan Turan-Dizdar, Burhanettin Gönüldaş, Sema Savcı, Melda Sağlam, Cemalettin Aksoy, Umut Arslan, Hatice-Serap Sivri
Mucopolysaccharidosis type VI (MPS VI) is a lysosomal storage disorder (LSD) characterized by a chronic, progressive course with multiorgan involvement. In our study, clinical, biochemical, molecular findings, and response to enzyme replacement therapy (ERT) for at least 6 months were evaluated in 20 patients with MPS VI. Treatment effects on clinical findings such as liver and spleen sizes, cardiac and respiratory parameters, visual and auditory changes, joints' range of motions, endurance tests and changes in urinary glycosaminoglycan excretions, before and after ERT were analyzed...
September 8, 2017: American Journal of Medical Genetics. Part A
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