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https://www.readbyqxmd.com/read/28725155/a-case-of-severe-erythema-nodosum-induced-by-methimazole
#1
Selma Emre, Didem Ozdemir, Sibel Orhun, Goknur Kalkan, Sertac Sener
Erythema nodosum (EN), is the most common variant of septal panniculitis and is possibly a delayed hypersensitivity reaction triggered by a wide range of antigenic stimuli. Hypersensitivity reactions due to medications have been recognized as a cause of 3-10% of EN cases. Case reports of EN associated with the anti-thyroid drugs are quite rarely reported in the literature even if there is a common use of anti-thyroid drugs. We report an EN case due to methimazole. The complaints of patients arose immediately fifteen days after the beginning of methimazole treatment...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28713740/the-effects-of-platelet-rich-fibrin-membrane-on-secondary-healing-after-pleomorphic-adenoma-excision-in-the-hard-palate-a-preliminary-study
#2
Özer Erdem Gür, Nuray Ensari, Nevreste Didem Sonbay Yılmaz
AIM: This study aims to evaluate the effects of platelet-rich fibrin (PRF) membrane on secondary healing after pleomorphic adenoma (PA) excision in the hard palate. MATERIALS AND METHODS: PRF membranes were laid over mucosal defects which occurred following PA excision in the hard palate. The secondary healing process was monitored in the patients by follow-up examinations on postoperative days 5, 10, 15, 20, 25, 30, 35, and 40. RESULTS: In this preliminary study, epithelialization was observed to have completed on the 30(th) day of follow-up in the first patient and on the 35(th) day in the second and third patients...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28706603/proximal-flow-control-with-a-balloon-during-the-treatment-of-left-subclavian-artery-aneurysms
#3
Murat Ugurlucan, Metin Onur Beyaz, Didem Melis Oztas, Sena Azamat, Yilmaz Onal, Bulent Acunas, Ufuk Alpagut
No abstract text is available yet for this article.
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28689102/monthly-methylprednisolone-in-combination-with-interferon-beta-or-glatiramer-acetate-for-relapsing-remitting-multiple-sclerosis-a-multicentre-single-blind-prospective-trial
#4
Serkan Ozakbas, Bilge Piri Cinar, Gorkem Kosehasanoğullari, Turhan Kahraman, Didem Oz, Behice Bircan Kursun
OBJECTIVES: Multiple sclerosis is usually clinically characterized by repeated subacute relapses followed by remissions. Corticosteroids are used for relapses, and this treatment has been shown to increase the speed of recovery from these. We aimed to evaluate the efficacy and safety of pulsed methylprednisolone given every month as an add-on therapy to interferon beta or glatiramer acetate in patients with relapsing-remitting multiple sclerosis. PATIENTS AND METHODS: This was a multi-center, examiner-blinded, prospective study...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28671589/theranostic-liposome-nanoparticle-hybrids-for-drug-delivery-and-bioimaging
#5
Muharrem Seleci, Didem Ag Seleci, Thomas Scheper, Frank Stahl
Advanced theranostic nanomedicine is a multifunctional approach which combines the diagnosis and effective therapy of diseased tissues. Here, we investigated the preparation, characterization and in vitro evaluation of theranostic liposomes. As is known, liposome-quantum dot (L-QD) hybrid vesicles are promising nanoconstructs for cell imaging and liposomal-topotecan (L-TPT) enhances the efficiency of TPT by providing protection against systemic clearance and allowing extended time for it to accumulate in tumors...
July 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28670250/the-relationship-between-severity-of-disease-and-vitamin-d-levels-in-children-with-atopic-dermatitis
#6
Ozlem Su, Anıl Gülsel Bahalı, Ayşegül Doğan Demir, Dilek Bıyık Ozkaya, Selçuk Uzuner, Didem Dizman, Nahide Onsun
INTRODUCTION: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. AIM: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. MATERIAL AND METHODS: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28666578/outpatient-beta-blockers-and-survival-from-sepsis-results-from-a-national-cohort-of-medicare-beneficiaries
#7
Kathleen E Singer, Courtney E Collins, Julie M Flahive, Allison S Wyman, M Didem Ayturk, Heena P Santry
BACKGROUND: Elderly Americans suffer increased mortality from sepsis. Given that beta-blockers have been shown to be cardioprotective in critical care, we investigated outpatient beta-blocker prescriptions and mortality among Medicare beneficiaries admitted for sepsis. METHODS: We queried a 5% random sample of Medicare beneficiaries for patients admitted with sepsis. We used in-hospital and outpatient prescription drug claims to compare in-hospital and 30-day mortality based on pre-admission beta-blocker prescription and class of beta-blocker prescribed using univariate tests of comparison and multivariable logistic regression models and another class of medications for control...
June 24, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28657360/a-current-and-comprehensive-review-of-cyclin-dependent-kinase-%C3%A4-nhibitors-for-the-treatment-of-metastatic-breast-cancer
#8
Burak Bilgin, Mehmet An Sendur, Didem Şener Dede, Muhammed Bülent Akıncı, Bülent Yalçın
BACKGROUND: Resistance to endocrine treatment generally occurs over time, especially in the metastatic stage. In this paper, we aimed to review the mechanisms of cyclin-dependent kinases (CDK) 4/6 inhibition and clinical usage of new agents in the light of recent literature updates. SCOPE: A literature search was carried out using PubMed, Medline and ASCO and ESMO annual-meeting abstracts by using the following search keywords; "palbociclib", "abemaciclib", "ribociclib", "cyclin-dependent kinase inhibitors" and "CDK 4/6" in metastatic breast cancer (MBC)...
June 28, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28647559/mirna-146a-mirna-155-and-jnk-expression-levels-in-peripheral-blood-mononuclear-cells-according-to-grade-of-knee-osteoarthritis
#9
Ahu Soyocak, Hulyam Kurt, Merih Ozgen, Didem Turgut Cosan, Ertugrul Colak, Hasan Veysi Gunes
Osteoarthritis (OA) is the most common joint disease characterized by joint pain and a progressive loss of articular cartilage. OA known as a non-inflammatory disease. Despite this the recent studies are shown synovitis and low inflammation to have a role in OA pathophysiology. The aim of this study to determine the roles of a potential therapeutic targets miRNA-146a, miRNA-155 and JNK expression levels in OA patients. Peripheral mononuclear blood cells (PBMCs) were extracted from OA patients and healthy subjects...
June 21, 2017: Gene
https://www.readbyqxmd.com/read/28597761/metabolic-and-functional-evaluation-of-the-heart-and-lungs-in-pulmonary-hypertension-by-gated-2-18f-fluoro-2-deoxy-d-glucose-positron-emission-tomography
#10
Didem Saygin, Kristin B Highland, Samar Farha, Margaret Park, Jacqueline Sharp, Emir Charles Roach, W H Wilson Tang, James D Thomas, Serpil C Erzurum, Donald R Neumann, Frank P DiFilippo
Pulmonary hypertension (PH) is associated with a metabolic shift towards glycolysis in both the right ventricle and lung. This results in increased glucose uptake to compensate for the lower energy yield of glycolysis, which creates a potential for 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) to be a useful tool in the evaluation of participants with PH. We investigated the utility of PET for PH by comparing FDG-PET uptake in the right ventricle and lungs in 30 participants with PH and eight healthy controls and correlating these measurements with echocardiographic (ECHO) measurements and other traditional assessments commonly used in PH...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28579153/outcomes-of-external-septorhinoplasty-in-a-turkish-male-population
#11
Gamze Didem Kilci, Engin Başer, Ayşegül Verim, Ömer Faruk Çalim, Bayram Veyseller, Orhan Özturan, Ahmet Altintaş, Mustafa Çelik
INTRODUCTION: The first and one of the most important steps in facial plastic surgery is accurate preoperative facial analysis and recording of data that may help the surgeon to check the outcomes of his/her techniques, promoting a surgeon's professional development. OBJECTIVE: To evaluate the esthetic outcomes of external septorhinoplasty (SRP) relevant to ethnic facial harmony and to investigate the relationship of the columellar incision scar with the type of skin and columellar incision type in a Turkish population...
May 20, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28579067/the-beneficial-effect-of-fesoterodine-a-competitive-muscarinic-receptor-antagonist-on-erectile-dysfunction-in-streptozotocin-induced-diabetic-rats
#12
Didem Yilmaz-Oral, Nur Bayatli, Serap Gur
OBJECTIVE: To investigate the possible role of fesoterodine (a competitive muscarinic receptor antagonist) on erectile dysfunction (ED) in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: A total of 16 adult male Sprague-Dawley rats were equally divided into control and diabetic group. Diabetes was induced by a single intravenous injection of streptozotocin (25-35mg/kg). In vivo erectile responses were evaluated by the stimulation of cavernosal nerves and repeated after intracavernosal injection of fesoterodine (1µM) in rats...
June 1, 2017: Urology
https://www.readbyqxmd.com/read/28577450/n-acetylcysteine-induced-vasodilatation-is-modulated-by-katp-channels-na-k-atpase-activity-and-intracellular-calcium-concentration-an-in-vitro-study
#13
Özden Vezir, Ülkü Çömelekoğlu, Nehir Sucu, Ali Erdinç Yalın, Şakir Necat Yılmaz, Serap Yalın, Fatma Söğüt, Selma Yaman, Kezban Kibar, Merih Akkapulu, Meryem İlkay Koç, Didem Seçer
BACKGROUND: In this study, we aimed to investigate the role of ATP-sensitive potassium (KATP) channel, Na(+)/K(+)-ATPase activity, and intracellular calcium levels on the vasodilatory effect of N-acetylcysteine (NAC) in thoracic aorta by using electrophysiological and molecular techniques. METHODS: Rat thoracic aorta ring preparations and cultured thoracic aorta cells were divided into four groups as control, 2mM NAC, 5mM NAC, and 10mM NAC. Thoracic aorta rings were isolated from rats for measurements of relaxation responses and Na(+)/K(+)-ATPase activity...
March 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28559981/examination-of-histopathological-changes-of-scalpel-monopolar-bipolar-and-thermocautery-applications-in-rat-experimental-circumcision-model
#14
Ahmet Ali Tuncer, Mehmet Fatih Bozkurt, Altınay Bayraktaroğlu, Halit Buğra Koca, Ismet Doğan, Salih Çetinkursun, Didem Baskın Embleton
This study endeavors to analyze the effects of thermocautery, bipolar cautery, monopolar cautery, and the scalpel to show that the thermocautery is a safe device to be used in circumcision. Twenty-four rats were assigned to 4 different groups: the scalpel, thermocautery, bipolar cautery, and monopolar cautery groups. Circumcisions were performed using the scalpel, thermocautery, bipolar cautery, or monopolar cautery devices. The circumcised foreskin was removed for histopathological analysis. The circumcision techniques were compared in terms of the depth of injury on the prepuce...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28554748/nephrogenic-adenoma-of-the-urinary-tract-a-6-year-single-center-experience
#15
Didem Turcan, Mustafa Fuat Acikalin, Evrim Yilmaz, Funda Canaz, Deniz Arik
BACKGROUND: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. MATERIALS AND METHODS: A retrospective series of 21 cases of nephrogenic adenoma in 18 patients, which were diagnosed in our department between 2010 and 2016, were analyzed...
March 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28523038/a-comparison-of-preoperative-and-postoperative-testicular-volume-and-blood-flow-in-patients-with-inguinal-hernia-hydrocele-and-cord-cyst-a-prospective-cohort-study
#16
Ahmet Ali Tuncer, Tamer Peker, Mehtap Berke Acar, Didem Baskin Embleton, Salih Cetinkursun
OBJECTIVE: To evaluate the effect of inguinal operations performed with a modified Ferguson technique upon testicular volume and blood flow. METHODS: This study involved 23 children receiving surgery for inguinal hernia, hydrocele, and cord cyst. This was a prospective study performed between April 2016 and June 2016 in a medical faculty pediatric surgery unit. The color Doppler ultrasound (CDUS) was used to assess testicular volume and blood flow before and after a modified Ferguson technique surgery...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28516091/treatment-of-dacron-grafting-dilatation-with-endovascular-stent-graft%C3%A4-ng
#17
Murat Ugurlucan, Didem Melis Oztas, Yilmaz Onal, Cagla Canbay, Omer Ali Sayin, Mehmet Barburoglu, Muslum Ercument Filik, Deniz Ocal, Mehmet Buget, Bulent Acunas, Ufuk Alpagut
Dacron grafts are frequently used during surgical revascularization procedures. Complications including graft thrombosis and infection are well known; however, aneurysm formation is extremely rare. In this report, we describe dilatation of a Dacron graft detected four years after aortobifemoral bypass procedure in a 50-year-old male patient who was treated with endovascular stent grafting.
October 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28483731/evaluation-of-patients-with-cystic-echinococcosis
#18
Emine Türkoğlu, Neşe Demirtürk, Havva Tünay, Murat Akıcı, Gürhan Öz, Didem Baskin Embleton
OBJECTIVE: Cystic echinococcosis (CE) is a globally prevalent zoonotic disease. METHODS: Demographic, clinical, laboratory, and follow-up data of patients between May 2009 and 2015 were retrospectively analyzed by screening data from a hospital automation system. RESULTS: A total of 238 (females, n=139 and males, n=99) patients with a mean age of 40.6±20.58 years were included. Less than half (40.8%) of the patients were living in the countryside...
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28465260/is-ultrasonographically-detected-nodule-diameter-concordant-with-pathological-tumor-size
#19
Muhammet Cuneyt Bilginer, Didem Ozdemir, Husniye Baser, Hayriye Tatli Dogan, Abdussamed Yalcin, Reyhan Ersoy, Bekir Cakir
INTRODUCTION: We aimed to compare preoperative ultrasonographical and postoperative histopathological diameters of differentiated thyroid cancer (DTC) lesions and investigate possible factors that can predict the discordance between two measurements. METHODS: Data of patients with histopathologically confirmed DTC were reviewed retrospectively. Nodules evaluated by preoperative US were matched with histopathologically examined nodules. Incidental tumors and nodules that can not be matched in US and histopathology reports were excluded...
June 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28438279/can-kinesio-tape-be-used-as-an-ankle-training-method-in-the-rehabilitation-of-the-stroke-patients
#20
Belma Fusun Koseoglu, Asuman Dogan, Hilmi Umut Tatli, Didem Sezgin Ozcan, Cemile Sevgi Polat
OBJECTIVE: To investigate the effects of the kinesio tape application to the tibialis anterior on rehabilitation outcomes of the stroke patients. DESIGN AND SETTING: Twenty patients with stroke were allocated into two groups: the first group of ten patients was assigned to receive kinesio tape in addition to the conventional rehabilitation program while a second group of 10 patients was assigned to receive a conventional rehabilitation program only. MAIN OUTCOME MEASURES: The clinical variables and health-related quality of life (HRQoL) were evaluated at baseline and at the end of the forth week...
May 2017: Complementary Therapies in Clinical Practice
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