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"Functional capacity"

Peter Augat, Christian von Rüden
Internal fixation of bone fractures by plate osteosynthesis has continuously evolved for more than 100 years. The aim of internal fracture fixation has always been to restore the functional capacity of the broken bone. The principal requirements of operative fracture management, those being anatomical fracture reduction, durable fixation, preservation of biology, promotion of fracture healing and early patient mobilization, have always been crucial but were accomplished to different extents depending on the focus of the specific fracture fixation principle employed...
June 2018: Injury
Marina Navarro-Peñalver, M Teresa Perez-Martinez, Manuel Gómez-Bueno, Pablo García-Pavía, Josep Lupón-Rosés, Eulalia Roig-Minguell, Josep Comin-Colet, Antoni Bayes-Genis, Jose A Noguera, Domingo A Pascual-Figal
BACKGROUND: Testosterone deficiency is associated with heart failure (HF) progression and poor prognosis. Testosterone therapy has been shown to improve exercise capacity in patients with chronic HF, but no trial has evaluated the impact of replacement in patients with demonstrated testosterone deficiency. METHODS: Prospective, randomized, double-blind, placebo-controlled, and parallel-group trial comparing testosterone replacement with placebo in males with chronic HF with reduced ejection fraction (HFrEF) and testosterone deficiency (NCT01813201)...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
Gislaine S Kogure, Rafael C Silva, Cristiana L Miranda-Furtado, Victor B Ribeiro, Daiana C C Pedroso, Anderson S Melo, Rui A Ferriani, Rosana Maria Dos Reis
Kogure, GS, Silva, RC, Miranda-Furtado, CL, Ribeiro, VB, Pedroso, DCC, Melo, AS, Ferriani, RA, and Reis, RMd. Hyperandrogenism enhances muscle strength after progressive resistance training, independent of body composition, in women with polycystic ovary syndrome. J Strength Cond Res XX(X): 000-000, 2018-The effects of resistance exercise on muscle strength, body composition, and increase in cross-sectional area of skeletal muscle (hypertrophy) were evaluated in women with polycystic ovary syndrome (PCOS). This case-control study included 45 PCOS and 52 non-PCOS women, with age between 18-37 years and body mass index of 18-39...
June 20, 2018: Journal of Strength and Conditioning Research
Stefania Paolillo, Piergiuseppe Agostoni, Fabiana De Martino, Francesca Ferrazzano, Fabio Marsico, Paola Gargiulo, Elisabetta Pirozzi, Caterina Marciano, Santo Dellegrottaglie, Pasquale Perrone Filardi
Exercise intolerance is a typical manifestation of patients affected by heart failure with reduced ejection fraction (HFrEF); however, the relationship among functional capacity, mortality, and exercise-induced heart rate response during exercise remains unclear in either sinus rhythm or atrial fibrillation subjects. Heart rate increase during incremental load exercise has a typical pattern in normal subjects, whereas it is commonly compromised in HFrEF patients, mainly due to the imbalance of the autonomic nervous system...
July 2018: Heart Failure Reviews
Katja Waller, Henri Vähä-Ypyä, Timo Törmäkangas, Pekka Hautasaari, Noora Lindgren, Paula Iso-Markku, Kauko Heikkilä, Juha Rinne, Jaakko Kaprio, Harri Sievänen, Urho M Kujala
Moderate-to-vigorous physical activity (MVPA) in old age is an important indicator of good health and functional capacity enabling independent living. In our prospective twin cohort study with 616 individuals we investigated whether long-term physical activity assessed three times, in 1975, 1982 and 1990 (mean age 48 years in 1990), and other self-reported health habits predict objectively measured MVPA measured with a hip-worn triaxial accelerometer (at least 10 hours per day for at least 4 days) 25 years later (mean age of 73 years)...
June 20, 2018: Scientific Reports
Jordan L Schultz, Annie Killoran, Peg C Nopoulos, Chloe C Chabal, David J Moser, John A Kamholz
OBJECTIVE: To determine whether tetrabenazine (TBZ) use is associated with an increased incidence of depression and/or suicidal ideation. METHODS: In this retrospective cross-sectional study of the Enroll-HD database, we used multiple logistic regression analyses to determine whether TBZ use is associated with an increased incidence of depression and/or suicidal ideation. For both dependent variables (depression and suicidality), separate analyses were conducted on (1) all participants, (2) only participants with a history of depression, and (3) only participants with no history of depression...
June 20, 2018: Neurology
T A Rodrigues, A O Freire, B F Bonfim, M S S Cartágenes, J B S Garcia
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated but conclusive findings are rare. Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects in decreasing the risk of fractures and possible effect in reducing the progression of OA...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Romina P Grinspon, Silvia Gottlieb, Patricia Bedecarrás, Rodolfo A Rey
Introduction: The functional capacity of the testes in prepubertal boys with cryptorchidism before treatment has received very little attention. The assessment of testicular function at diagnosis could be helpful in the understanding of the pathophysiology of cryptorchidism and in the evaluation of the effect of treatment. Anti-Müllerian hormone is a well-accepted Sertoli cell biomarker to evaluate testicular function during childhood without the need for stimulation tests. Objective: The aim of the study was to assess testicular function in prepubertal children with cryptorchidism before orchiopexy, by determining serum anti-Müllerian hormone (AMH)...
2018: Frontiers in Endocrinology
Voitto Järvimäki, Lotta Juurikka, Merja Vakkala, Hannu Kautiainen, Maija Haanpää
Background and aim No studies have been published regarding the results of lumbar spine surgery a in population-based setting in Finland. Our objective was to investigate functional capacity and quality of life after lumbar spine surgery in a population-based cohort in Northern Finland, focusing on working-age patients. Methods This was a cross-sectional postal survey. Three questionnaires (a self-made questionnaire, the Oswestry Low Back Disability Questionnaire and the SF-36) were sent the patients aged 18-65 years who had undergone lumbar spine surgery due to disc herniation, instability or spinal stenosis in the Oulu University Hospital between June 2005 and May 2008...
December 29, 2017: Scandinavian Journal of Pain
Cristina Gardelli, Hiroki Wada, Asim Ray, Moya Caffrey, Antonio Llinas, Igor Shamovsky, Joakim Tholander, Joakim Larsson, Ulf Sivars, Leif Hultin, Ulf Andersson, Hitesh J Sanganee, Kristina Stenvall, Brith Leidvik, Karin Gedda, Lisa Jinton, Marie Ryden Landergren, Kostas Karabelas
Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to increase of IGF-1 plasma levels. The activation of the GH/IGF-1 axis leads to an increase of muscle mass and functional capacity. Ghrelin further acts on inflammation, appetite and adipogenesis, and for this reason was considered an important target to address catabolic conditions...
June 17, 2018: Journal of Medicinal Chemistry
Jalil Mehrzad, Abbas Bahari, Mohammad Reza Bassami, Mahmoud Mahmoudi, Hesam Dehghani
We assessed the effects of naturally occurring levels of AFB1 on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs) by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB1 led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing direction of DCs. Flow cytometry data confirmed a damage towards DCs, i...
June 2018: Data in Brief
Galit Alter, Tom H M Ottenhoff, Simone A Joosten
Antibodies are antigen recognizing immunoglobulins with an amazingly diverse repertoire in the antigen specific domain. The diversity of the antibody response is further increased by modifications such as somatic recombination and hypermutation. Furthermore, variation in the isotype and post-translational modifications such as Fc glycosylation further increase diversity of the effector functions. In particular variations in the glycan structures contribute significantly to the functional capacities of the antibodies...
June 11, 2018: Seminars in Immunology
Bruce A Griffin, Julie A Lovegrove
No abstract text is available yet for this article.
June 13, 2018: Journal of Nutrition
Yujin Myung, Bomi Choi, Heeyeon Kwon, Chan Yeong Heo, Eun-Kyu Kim, Eunyoung Kang, Jae Hoon Jeong, Eun Joo Yang
Immediate breast reconstruction (IBR) after mastectomy has been proven to affect patient quality of life, psychological well-being, and functional capacities. In the present study, we aimed to investigate the effect of breast reconstruction on postoperative shoulder function and muscle performance by evaluating isokinetic muscle performance tests.A retrospective chart review to collect data on shoulder function analysis with isokinetic muscle performance testing was performed among patients who received mastectomy with IBR from July 2013 to March 2015...
June 2018: Medicine (Baltimore)
Moon H Nahm, Jigui Yu, Hailey P Weerts, Heather Wenzel, Chitradevi S Tamilselvi, Lakshmi Chandrasekaran, Marcela F Pasetti, Sachin Mani, Robert W Kaminski
Shigella is an important cause of diarrhea worldwide, with serotypes Shigella flexneri 2a, S. flexneri 3a, and Shigella sonnei demonstrating epidemiological prevalence. Many development efforts are focused on Shigella lipopolysaccharide (LPS)-based vaccines, as O antigen-specific conjugate vaccines are immunogenic and efficacious. Immunization with Shigella vaccines containing LPS can elicit antibodies capable of killing Shigella in a serotype-specific manner. Thus, to facilitate Shigella vaccine development, we have developed a serum bactericidal assay (SBA) specific for three Shigella serotypes that measures killing of target bacteria at multiple serum dilutions and in the presence of exogenous complement...
June 27, 2018: MSphere
P Rocca, S Galderisi, A Rossi, A Bertolino, P Rucci, D Gibertoni, C Montemagni, S Bellino, E Aguglia, M Amore, A Bellomo, M Biondi, B Carpiniello, A Cuomo, E D'Ambrosio, L dell'Osso, P Girardi, C Marchesi, P Monteleone, C Montemitro, L Oldani, F Pacitti, R Roncone, A Siracusano, E Tenconi, A Vita, P Zeppegno, L Steardo, A Vignapiano, M Maj
BACKGROUND: A general consensus has not yet been reached regarding the role of disorganization symptoms in real-world functioning in schizophrenia. METHODS: We used structural equations modeling (SEM) to analyze the direct and indirect associations between disorganization and real-world functioning assessed through the Specific Levels of Functioning Scale (SLOF) in 880 subjects with schizophrenia. RESULTS: We found that: 1) conceptual disorganization was directly and strongly connected with SLOF daily activities; difficulty in abstract thinking was associated with moderate strength to all SLOF domains, and poor attention was connected with SLOF work skills; 2) grandiosity was only related with poor work skills, and delusions were associated with poor functioning in all SLOF domains; interpersonal relationships were weakly indirectly influenced by hallucinatory behavior, delusions and unusual thought contents through the mediation of social cognition (SC); 3) among the negative symptoms, avolition had only direct links with SLOF work skills and SLOF activities; anhedonia had direct links with SLOF work skills and SLOF interpersonal and indirect link with SLOF work skills through functional capacity (FC); asociality with SLOF interpersonal; blunted affect had direct links with SLOF activities and indirect links with SLOF interpersonal relationships mediated by SC...
June 10, 2018: Schizophrenia Research
Kimiko Tomioka, Norio Kurumatani, Hiroshi Hosoi
BACKGROUND: There is insufficient evidence regarding the relationship of home environment with functional capacity among community-dwelling older people without disabilities. We conducted a population-based longitudinal cohort study and examined whether stairs in the home were associated with capability to perform instrumental activities of daily living (IADL) in community-dwelling high-functioning older adults. METHODS: The target population was individuals aged 65 years or older living in two municipalities in Nara Prefecture in Japan...
June 4, 2018: BMC Geriatrics
Gianluigi Galizia, Giulio Balestrieri, Beatrice De Maria, Cinzia La Storia, Mauro Monelli, Stefano Salvaderi, Giuseppe Romanelli, Laura A Dalla Vecchia
BACKGROUND: Any acute event, either primary or secondary to a chronic disease, is generally followed by some degree of physical impairment. The Sub-Acute Care (SAC) represents one of the inpatient intermediate care settings aimed at completing recovery and restoring functional capacity. Debate exists on the role of the rehabilitation treatment in the SAC setting. AIM: To compare the outcomes of patients managed in two different SAC Units where A) patients undergo an individualized rehabilitation program on top of optimal medical therapy (OMT) B) patients receive OMT only...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
Oladipupo O Fakoya, Emmanuel A Abioye-Kuteyi, Ibrahim S Bello, Olarenwaju O Oyegbade, Samuel A Olowookere, Ikechi T Ezeoma
Background Aging is associated with change in health status and decreasing functional capacity affecting the general well-being of individuals with increase in the prevalence of chronic noncommunicable diseases. Objective This study aimed to assess the quality of life (QoL) and its determinants in elderly patients attending a general practice clinic in Southwest Nigeria. Method Descriptive cross-sectional study of consenting elderly patients completed an interviewer-administered questionnaire on QoL and its determinants...
January 1, 2018: International Quarterly of Community Health Education
Cristiana Vitale, Spoletini Ilaria, Giuseppe Mc Rosano
Heart failure (HF) is characterised by exercise intolerance, which substantially impairs quality of life (QOL) and prognosis. The aim of this review is to summarise the state of the art on pharmacological interventions that are able to improve exercise capacity in HF. Ivabradine, trimetazidine and intravenous iron are the only drugs included in the European Society of Cardiology HF guidelines that have consistently been shown to positively affect functional capacity in HF. The beneficial effects on HF symptoms, physical performance and QOL using these pharmacological approaches are described...
May 2018: Cardiac Failure Review
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