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"Physical function"

Futoshi Matsushita, Hirotaka Kida, Ken-Ichi Tabei, Chizuru Nakano, Keita Matsuura, Yuichiro Ii, Ryogen Sasaki, Akira Taniguchi, Yugo Narita, Masayuki Maeda, Masayuki Satoh, Hidekazu Tomimoto
Introduction: This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS). Methods: A total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non-CL. In-house software was used to quantitatively determine the atrophy of each brain region...
March 2018: Brain and Behavior
Regina Wing Shan Sit, Keith Kwok Wai Chan, Benjamin Hon Kei Yip, Daisy Dexing Zhang, Kenneth Dean Reeves, Ying Ho Chan, Vincent Chi Ho Chung, Samuel Yeung Shan Wong
INTRODUCTION: Knee osteoarthritis (KOA) is a common, disabling and costly medical condition. The patellofemoral joint is a critical source of pain in individuals with KOA, and coexistence of patellofemoral osteoarthritis (PFOA) and tibiofemoral osteoarthritis (TFOA) is sometimes observed. The identification of subgroups with PFOA and customised interventions to correct underlying pathomechanics is beneficial for individuals with KOA. This study aims to evaluate whether a clinic-based patella mobilisation therapy (PMT) leads to significant improvement in pain, physical function and quality of life of individuals with KOA...
March 14, 2018: BMJ Open
Lucas Bet da Rosa Orssatto, Bruno Monteiro de Moura, Ewertton de Souza Bezerra, Lars Louis Andersen, Silas Nery de Oliveira, Fernando Diefenthaeler
Understanding the influence of strength training intensity on subsequent recovery in elderly is important to avoid reductions in physical function during the days following training. Twenty-two elderly were randomized in two groups: G70 (65.9 ± 4.8 years, n = 11) and G95 (66.9 ± 5.1, n = 11). Baseline tests included maximum voluntary isometric contraction (peak torque and rate of torque development - RTD), countermovement jump, and functional capacity (timed up and go, stairs ascent and descent)...
March 11, 2018: Experimental Gerontology
Jonathan D Gelber
No abstract text is available yet for this article.
April 2018: Clinical Orthopaedics and related Research
Bunny J Pozehl, Rita Mcguire, Kathleen Duncan, Melody Hertzog, Pallav Deka, Joseph Norman, Nancy T Artinian, Matthew A Saval, Steven J Keteyian
BACKGROUND: Few studies report objective accelerometer-measured daily physical activity levels in patients with heart failure (HF). OBJECTIVE: We examined baseline accelerometer-measured physical activity from the Heart Failure Exercise and Resistance Training Camp trial, a federally funded (R01-HL112979) 18-month intervention study to promote adherence to exercise in patients with HF. Factors associated with physical activity levels were also explored. METHODS: Patients with diagnosed HF (stage C chronic HF confirmed by echocardiography and clinical evaluation) were recruited from 2 urban medical centers...
March 12, 2018: Journal of Cardiovascular Nursing
Daigo Kojima, Nobukazu Komoribayashi, Shinichi Omama, Kohki Oikawa, Shunrou Fujiwara, Masakazu Kobayashi, Yoshitaka Kubo, Kazunori Terasaki, Kuniaki Ogasawara
PURPOSE: Whereas SPECT images obtained 180 minutes after administration of I-iomazenil (IMZ) (late images) are proportional to the distribution of central benzodiazepine receptor-binding potential, SPECT images obtained within 30 minutes after I-IMZ administration (early images) correlate with regional brain perfusion. The aim of the present study was to determine whether crossed cerebellar tracer uptake on acute-stage I-IMZ SPECT imaging predicts 3-month functional outcome in patients with nonfatal hypertensive putaminal or thalamic hemorrhage...
March 13, 2018: Clinical Nuclear Medicine
Andrea A Cohee, Silvia M Bigatti, Cleveland G Shields, Shelley A Johns, Timothy Stump, Patrick O Monahan, Victoria L Champion
BACKGROUND: Partners of breast cancer survivors experience the effects of a spouse's cancer years after treatment. Partners of younger survivors (YPs) may experience greater problems than partners of older survivors (OPs), just as younger survivors experience greater problems than their older counterparts. OBJECTIVES: The aims of this study were to (1) compare quality of life (QoL) in YPs and OPs and (2) determine contributing factors to each group's QoL. METHODS: Cross-sectional data were collected from YPs (n = 227) and OPs (n = 281) through self-report...
March 13, 2018: Cancer Nursing
Clark DuMontier, Kerri M Clough-Gorr, Rebecca A Silliman, Andreas E Stuck, André Moser
OBJECTIVES: To develop a predictive model and risk score for 10-year mortality using health-related quality of life (HRQOL) in a cohort of older women with early-stage breast cancer. DESIGN: Prospective cohort. SETTING: Community. PARTICIPANTS: U.S. women aged 65 and older diagnosed with Stage I to IIIA primary breast cancer (N=660). MEASUREMENTS: We used medical variables (age, comorbidity), HRQOL measures (10-item Physical Function Index and 5-item Mental Health Index from the Medical Outcomes Study (MOS) 36-item Short-Form Survey; 8-item Modified MOS Social Support Survey), and breast cancer variables (stage, surgery, chemotherapy, endocrine therapy) to develop a 10-year mortality risk score using penalized logistic regression models...
March 13, 2018: Journal of the American Geriatrics Society
Shalender Bhasin, Caroline M Apovian, Thomas G Travison, Karol Pencina, Lynn L Moore, Grace Huang, Wayne W Campbell, Zhuoying Li, Andrew S Howland, Ruo Chen, Philip E Knapp, Martha R Singer, Mitali Shah, Kristina Secinaro, Richard V Eder, Kathleen Hally, Haley Schram, Richelle Bearup, Yusnie M Beleva, Ashley C McCarthy, Erin Woodbury, Jennifer McKinnon, Geeta Fleck, Thomas W Storer, Shehzad Basaria
Importance: The Institute of Medicine set the recommended dietary allowance (RDA) for protein at 0.8 g/kg/d for the entire adult population. It remains controversial whether protein intake greater than the RDA is needed to maintain protein anabolism in older adults. Objective: To investigate whether increasing protein intake to 1.3 g/kg/d in older adults with physical function limitations and usual protein intake within the RDA improves lean body mass (LBM), muscle performance, physical function, fatigue, and well-being and augments LBM response to a muscle anabolic drug...
March 12, 2018: JAMA Internal Medicine
Susan M Smith, Emma Wallace, Chris Salisbury, Maxime Sasseville, Elizabeth Bayliss, Martin Fortin
PURPOSE: We aimed to develop a consensus-based set of core outcomes specifically for studies in multimorbidity. METHODS: We undertook a consensus study following the COS-STAR (Core Outcome Set-STAndards for Reporting) guidelines for the design and reporting of core outcome sets. A Delphi panel of experts completed a web-based survey with 2 rounds. Panelists were presented with a range of outcomes that had been identified in previous workshops and a related systematic review...
March 2018: Annals of Family Medicine
Anders Odgaard, Frank Madsen, Per Wagner Kristensen, Andreas Kappel, Jesper Fabrin
BACKGROUND: Controversy exists over the surgical treatment for severe patellofemoral osteoarthritis. We therefore wished to compare the outcome of patellofemoral arthroplasty (PFA) with TKA in a blinded randomized controlled trial. QUESTIONS/PURPOSES: In the first 2 years after surgery: (1) Does the overall gain in quality of life differ between the implants based on the area under the curve of patient-reported outcomes (PROs) versus time? (2) Do patients obtain a better quality of life at specific points in time after PFA than after TKA? (3) Do patients get a better range of movement after PFA than after TKA? (4) Does PFA result in more complications than TKA? METHODS: Patients were eligible if they had debilitating symptoms and isolated patellofemoral disease...
January 2018: Clinical Orthopaedics and related Research
Jasvinder A Singh
Objective: There are no qualitative studies of sleep in gout; the aim of this study was to examine the impact of gout on sleep. Methods: Nine nominal groups were conducted, oversampling for African-Americans and women with gout. Patients discussed and rank-ordered their concerns. Results: Nine nominal groups with 46 gout patients were conducted with mean age, 61 years (s.d. 10.6) and gout duration, 14.9 years (s.d. 12); 63% were men, 46% African-American, 52% married, 46% retired and 63% were allopurinol users...
February 23, 2018: Rheumatology
Melissa Y Wei, Mohammed U Kabeto, Andrzej T Galecki, Kenneth M Langa
Background: Multimorbidity is common among older adults and strongly associated with physical functioning decline and increased mortality. However, the full spectrum of direct and indirect effects of multimorbidity on physical functioning and survival has not been quantified. We aimed to determine the longitudinal relationship of multimorbidity on physical functioning and quantify the impact of multimorbidity and multimorbidity-attributed changes in physical functioning on mortality risk...
February 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Gergely Horváth, Teodóra Keleti, Mihály Makara, Gabor S Ungvari, Gábor Gazdag
PURPOSE: To assess the quality of life (QoL) of patients with hepatitis C infection (HCI) and its correlations with demographic and clinical variables. DESIGN AND METHODS: QoL and depressive symptoms were evaluated with the validated rating instruments of the 36-item short form (SF-36) generic health survey and the second version of the self-rated Beck depression inventory (BDI-II) in a cross-sectional design and correlated with basic demographic and clinical variables, including the Fibroscan score, which indicates the severity of liver impairment...
March 12, 2018: Perspectives in Psychiatric Care
U Chae, N-R Park, E-S Kim, J-Y Choi, M Yim, H-S Lee, S-R Lee, S Lee, J-W Park, D-S Lee
Spinal deformities such as scoliosis and kyphosis are incurable, and can lead to decreased physical function, pain, and reduced quality of life. Despite much effort, no clear therapies for the treatment of these conditions have been found. Therefore, the development of an animal model for spinal deformity would be extremely valuable to our understanding of vertebral diseases. In this study, we demonstrate that mice deficient in the mitochondrial enzyme isocitrate dehydrogenase 2 (IDH2) develop spinal deformities with aging...
March 12, 2018: Physiological Research
Shanshan Li, Kaitlin Hagan, Francine Grodstein, Tyler J VanderWeele
Background: Social integration has been related to risk of chronic diseases and mental health conditions. Purpose: We investigated the association between social integration in midlife with subsequent health and well-being in aging. Methods: We included women from the Nurses' Health Study in the United States, who had no major chronic diseases in 1996 when we assessed social integration, using the Berkman-Syme Social Network Index. We defined healthy aging after 16 years of follow-up, when women ranged from 66 to 91 years, on the basis of survival along with 4 health criteria, assessed in 2012: no history of major chronic disease diagnosis, no self-reported impairment in memory, and no major impairments in physical function or mental health...
March 2018: Preventive Medicine Reports
Jennifer L Steiner, Silvia M Bigatti, James E Slaven, Dennis C Ang
PURPOSE: Fibromyalgia (FM) is typically associated with the experience of diffuse pain and physical impairment. Depression also commonly co-exists in patients with FM, and has been correlated with pain intensity and physical functioning. Previous research suggests an association between pain intensity and physical functioning; however, the direct causal relationship between improvements in pain intensity and in functioning is not observed in many FM patients. This may suggest that another factor such as depression is mediating this relationship...
December 2017: Journal of Applied Biobehavioral Research
F Acciai
OBJECTIVES: Social inequalities in health have been largely documented in social science research. Members of the most disadvantaged groups experience worse health and higher mortality from birth throughout adulthood. However, it is not clear whether this association persists at older ages. Some studies have found a narrowing of the social gradient in health, at least when 'traditional' measures of socio-economic status (SES)-income, education, and occupation-are used. The main goal of the article is to highlight similarities and discrepancies in the age trend of social inequalities in health that arise when multiple measures of SES are considered...
March 7, 2018: Public Health
Yuan-Yuan Lei, Suzanne C Ho, Ashley Cheng, Carol Kwok, Chi-Kiu Iris Lee, Ka Li Cheung, Roselle Lee, Herbert H F Loong, Yi-Qian He, Winnie Yeo
Background: The 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guideline provides recommendations for cancer prevention among cancer survivors. Limited data have examined whether guideline adherence is related to health-related quality of life (HRQoL) among Chinese patients with breast cancer. Methods: An ongoing prospective cohort study involving 1,462 Chinese women with early-stage breast cancer assessed exercise, diet, and body mass index (BMI) at baseline and at 18-months follow-up after diagnosis...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Giulia Malaguarnera, Manuela Pennisi, Gaetano Bertino, Massimo Motta, Antonio Maria Borzì, Enzo Vicari, Rita Bella, Filippo Drago, Michele Malaguarnera
BACKGROUND: Minimal Hepatic Encephalopathy (MHE) is characterized by an impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL). The aim of our study is evaluating the potential liver health promoting a perspective of Resveratrol (RV) activities and evaluate whether RV treatment may improve health related quality of life (HRQL) and reduce depression and anxiety in patients with MHE. METHODS: W e evaluated depression using the Beck Depression Inventory test, anxiety with State-trait anxiety inventory test, quality of life through SF-36 test, and ammonia serum levels in 70 MHE patients that were randomized into two groups...
March 9, 2018: Nutrients
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