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https://www.readbyqxmd.com/read/28918552/long-term-quality-of-life-profile-in-oncology-a-comparison-between-cancer-survivors-and-the-general-population
#1
Maria Antonietta Annunziata, Barbara Muzzatti, Cristiana Flaiban, Katiuscia Gipponi, Carlo Carnaghi, Paolo Tralongo, Michele Caruso, Raffaele Cavina, Umberto Tirelli
PURPOSE: Understanding the quality of life (QoL) of cancer survivors is relevant to both clinical practice and health care policy. The current study compared the QoL profile in this specific population with that of a normative sample for the general population, as well as with those of both healthy and oncological patients normative sub-samples. In addition, associations between the obtained QoL profile and the main socio-demographic and clinical characteristics of the sample were examined...
September 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28918362/there-are-no-no-responders-to-low-or-high-resistance-training-volumes-among-older-women
#2
Matheus de Siqueira Mendes Barbalho, Paulo Gentil, Mikel Izquierdo, James Fisher, James Steele, Rodolfo de Azevedo Raiol
OBJECTIVES: To assess the prevalence of non-responders to different tests and to compare the effects of different resistance training (RT) volumes on muscle strength, anthropometric and functional performance of older women. METHODS: Three hundred seventy six women performed 12weeks of RT with either low or high volume (LV, 71.29±5.77years and HV 69.73±5.88years, respectively). Both groups performed the same exercises, and all parameters were held constant except for the number of sets performed per week...
September 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28918244/determinants-and-regulation-of-protein-turnover-in-yeast
#3
Miguel Martin-Perez, Judit Villén
Protein turnover maintains the recycling needs of the proteome, and its malfunction has been linked to aging and age-related diseases. However, not all proteins turnover equally, and the factors that contribute to accelerate or slow down turnover are mostly unknown. We measured turnover rates for 3,160 proteins in exponentially growing yeast and analyzed their dependence on physical, functional, and genetic properties. We found that functional characteristics, including protein localization, complex membership, and connectivity, have greater effect on turnover than sequence elements...
September 13, 2017: Cell Systems
https://www.readbyqxmd.com/read/28917551/-impact-of-the-preservation-of-the-branches-of-intercostobrachial-nerve-on-the-quality-of-life-of-patients-operated-for-a-breast-cancer
#4
Zenaba Saleh, Julia Salleron, Sandrine Baffert, Alain Paveau, Jean-Marc Classe, Frédéric Marchal
AIM: The aim of this study was to assess the impact of the preservation of the intercostobrachial nerve on the quality of life of patients operated for breast cancer. METHODS: This study was ancillary to cost comparison study of axillary sentinel lymph node detection and axillary lymphadenectomy in early breast cancer. It was a prospective multicenter, observational, non-randomized study. The quality of life was assessed using two questionnaires: QLQ-C30 and specific module QLQ-BR23 Surveys have been performed before initiation of surgery, one week, and 1 month, 8 months and 12 months after discharge from hospitalization for the first surgical procedure...
September 13, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28917267/distance-delivered-physical-activity-interventions-for-childhood-cancer-survivors-a-systematic-review-and-meta-analysis
#5
REVIEW
David Mizrahi, Claire E Wakefield, Joanna E Fardell, Veronica F Quinn, Qishan Lim, Briana K Clifford, David Simar, Kirsten K Ness, Richard J Cohn
This review aimed to determine the feasibility of distance-delivered physical activity (PA) interventions in childhood cancer survivors (CCS), and assess the effect on PA levels, and physical, physiological and psychological outcomes. We searched electronic databases until May 2016, including studies following intensive treatment. Meta-analyses were conducted on randomized controlled trials. We calculated the effect of interventions on PA levels and physical, physiological and psychological health outcomes...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28915863/lifestyle-intervention-to-improve-quality-of-life-and-prevent-weight-gain-after-renal-transplantation-design-of-the-active-care-after-transplantation-act-randomized-controlled-trial
#6
Gerald Klaassen, Dorien M Zelle, Gerjan J Navis, Desie Dijkema, Frederike J Bemelman, Stephan J L Bakker, Eva Corpeleijn
BACKGROUND: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. Another common post-transplantation complication is poor cardio-metabolic health, which plays a main role in long-term outcomes in renal transplant recipients (RTR). It is increasingly recognized that weight gain in the first year after transplantation, especially an increase in fat mass, is a highly common contributor to cardio-metabolic risk...
September 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28914503/testosterone-therapy-preserves-muscle-strength-and-power-in-aging-men-with-type-2-diabetes-a-randomized-controlled-trial
#7
L V Magnussen, L G Hvid, A P Hermann, D M Hougaard, B Gram, P Caserotti, M S Andersen
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available testosterone (BioT) levels. Thirty-nine men aged 50-70 years with type 2 diabetes and BioT levels <7.3 nmol/L were included from an academic tertiary-care medical center. Patients were randomized to testosterone gel (testosterone replacement therapy, n = 20) or placebo (n = 19) for 24 weeks, applying a double-blinded design...
September 2017: Andrology
https://www.readbyqxmd.com/read/28914380/secretory-sphingomyelinase-s-smase-activity-is-elevated-in-patients-with-rheumatoid-arthritis
#8
Beatriz Y Hanaoka, Michelle J Ormseth, C Michael Stein, Daipayan Banerjee, Mariana Nikolova-Karakashian, Leslie J Crofford
The goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected data on 33 patients who were diagnosed with RA and 17 non-RA controls who were comparable in terms of age, sex, and race. Demographic, clinical data and self-reported measures of fatigue, pain, and physical function were obtained directly from patients and controls...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28914116/defining-a-core-outcome-set-for-adolescent-and-young-adult-patients-with-a-spinal-deformity
#9
Marinus de Kleuver, Sayf S A Faraj, Roderick M Holewijn, Niccole M Germscheid, Raphael D Adobor, Mikkel Andersen, Hans Tropp, Benny Dahl, Heli Keskinen, Anders Olai, David W Polly, Miranda L van Hooff, Tsjitske M Haanstra
Background and purpose - Routine outcome measurement has been shown to improve performance in several fields of healthcare. National spine surgery registries have been initiated in 5 Nordic countries. However, there is no agreement on which outcomes are essential to measure for adolescent and young adult patients with a spinal deformity. The aim of this study was to develop a core outcome set (COS) that will facilitate benchmarking within and between the 5 countries of the Nordic Spinal Deformity Society (NSDS) and other registries worldwide...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28912631/subacute-effects-of-cervicothoracic-spinal-thrust-non-thrust-in-addition-to-shoulder-manual-therapy-plus-exercise-intervention-in-individuals-with-subacromial-impingement-syndrome-a-prospective-randomized-controlled-clinical-trial-pilot-study
#10
Alexis A Wright, Megan Donaldson, Craig A Wassinger, Alicia J Emerson-Kavchak
OBJECTIVES: To determine the subacute effects of cervicothoracic spinal thrust/non-thrust in addition to shoulder non-thrust plus exercise in patients with subacromial pathology. METHODS: This was a randomized, single blinded controlled trial pilot study. This trial was registered at ClinicalTrials.gov (NCT01753271) and reported according to Consolidated Standards of Reporting Trials requirements. Patients were randomly assigned to either shoulder treatment plus cervicothoracic spinal thrust/non-thrust or shoulder treatment-only group...
September 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28911978/effect-of-12-month-resistance-and-endurance-training-on-quality-quantity-and-function-of-skeletal-muscle-in-older-adults-requiring-long-term-care
#11
Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima
Older adults requiring long-term care will experience age-associated deterioration of the quality and quantity of skeletal muscle if no interventions are performed. Long-term training is considered a typical intervention method and is effective for improvement of both muscle quantity and physical function. However, how such training affects muscle quality [i.e., fat-to-muscle ratio as determined by echo intensity (EI)] in older adults requiring long-term care remains unclear. The purpose of this study was to investigate the effects of a 12-month physical training intervention on the quality and quantity of skeletal muscle, physical function, and blood chemistry in older adults requiring long-term care...
September 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28910814/feasibility-and-effectiveness-of-intervention-programmes-integrating-functional-exercise-into-daily-life-of-older-adults-a-systematic-review
#12
Michaela Weber, Nacera Belala, Lindy Clemson, Elisabeth Boulton, Helen Hawley-Hague, Clemens Becker, Michael Schwenk
BACKGROUND: Traditionally, exercise programmes for improving functional performance and reducing falls are organised as structured sessions. An alternative approach of integrating functional exercises into everyday tasks has emerged in recent years. OBJECTIVES: Summarising the current evidence for the feasibility and effectiveness of interventions integrating functional exercise into daily life. METHODS: A systematic literature search was conducted including articles based on the following criteria: (1) individuals ≥60 years; (2) intervention studies of randomised controlled trials (RCTs) and non-randomised studies (NRS); (3) using a lifestyle-integrated approach; (4) using functional exercises to improve strength, balance, or physical functioning; and (5) reporting outcomes on feasibility and/or effectiveness...
September 15, 2017: Gerontology
https://www.readbyqxmd.com/read/28910753/fall-prevalence-time-trend-and-its-related-risk-factors-among-elderly-people-in-china
#13
Hong Wu, Peng Ouyang
OBJECTIVES: To study the fall prevalence, time trends and related risk factors among elderly people in the Chinese mainland from 2011 to 2013. METHODS: Our data were from China Health and Retirement Longitudinal Study in 2011 and 2013. The population sample included people aged 60 years and over. Whether the person had experienced fall accident in the last two years was used to measure fall incidence. The time trend and age groups were investigated through the chi-square test...
September 1, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28910372/correlation-of-serum-cartilage-oligometric-matrix-protein-comp-and-interleukin-16-il-16-levels-with-disease-severity-in-primary-knee-osteoarthritis-a-pilot-study-in-a-malaysian-population
#14
Esha Das Gupta, Wei Ren Ng, Shew Fung Wong, Abdul Kareem Bhurhanudeen, Swan Sim Yeap
OBJECTIVE: The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. METHODS: Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28905359/guideline-recommended-medications-and-physical-function-in-older-adults-with-multiple-chronic-conditions
#15
Gail McAvay, Heather G Allore, Andrew B Cohen, Danijela Gnjidic, Terrence E Murphy, Mary E Tinetti
BACKGROUND/OBJECTIVES: The benefit or harm of a single medication recommended for one specific condition can be difficult to determine in individuals with multiple chronic conditions and polypharmacy. There is limited information on the associations between guideline-recommended medications and physical function in older adults with multiple chronic conditions. The objective of this study was to estimate the beneficial or harmful associations between guideline-recommended medications and decline in physical function in older adults with multiple chronic conditions...
September 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28904984/impact-of-diabetes-in-the-friedreich-ataxia-clinical-outcome-measures-study
#16
Ashley McCormick, Jennifer Farmer, Susan Perlman, Martin Delatycki, George Wilmot, Katherine Matthews, Grace Yoon, Chad Hoyle, Sub H Subramony, Theresa Zesiewicz, David R Lynch, Shana E McCormack
OBJECTIVE: Friedreich ataxia (FA) is a progressive neuromuscular disorder caused by GAA triplet repeat expansions or point mutations in the FXN gene. FA is associated with increased risk of diabetes mellitus (DM). This study assessed the age-specific prevalence of FA-associated DM and its impact on neurologic outcomes. RESEARCH DESIGN AND METHODS: Participants were 811 individuals with FA from 12 international sites in a prospective natural history study (FA Clinical Outcome Measures Study, FACOMS)...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28901935/partial-pancreatoduodenectomy-versus-duodenum-preserving-pancreatic-head-resection-in-chronic-pancreatitis-the-multicentre-randomised-controlled-double-blind-chropac-trial
#17
Markus K Diener, Felix J Hüttner, Meinhard Kieser, Phillip Knebel, Colette Dörr-Harim, Marius Distler, Robert Grützmann, Uwe A Wittel, Rebekka Schirren, Hans-Michael Hau, Axel Kleespies, Claus-Dieter Heidecke, Ales Tomazic, Christopher M Halloran, Torsten J Wilhelm, Marcus Bahra, Tobias Beckurts, Thomas Börner, Matthias Glanemann, Ulrich Steger, Frank Treitschke, Ludger Staib, Karsten Thelen, Thomas Bruckner, André L Mihaljevic, Jens Werner, Alexis Ulrich, Thilo Hackert, Markus W Büchler
BACKGROUND: There is substantial uncertainty regarding the optimal surgical treatment for chronic pancreatitis. Short-term outcomes have been found to be better after duodenum-preserving pancreatic head resection (DPPHR) than after partial pancreatoduodenectomy. Therefore, we designed the multicentre ChroPac trial to investigate the long-term outcomes of patients with chronic pancreatitis within 24 months after surgery. METHODS: This randomised, controlled, double-blind, parallel-group, superiority trial was done in 18 hospitals across Europe...
September 9, 2017: Lancet
https://www.readbyqxmd.com/read/28900828/everyday-life-following-hematopoietic-stem-cell-transplantation-decline-in-physical-symptoms-within-the-first-month-and-change-related-predictors
#18
Aleksandra Kroemeke, Małgorzata Sobczyk-Kruszelnicka, Zuzanna Kwissa-Gajewska
PURPOSE: Lower quality of life, especially in the physical domain (Physical-QOL), is common in patients after hematopoietic stem cell transplantation (HSCT). However, few studies explore changes in the Physical-QOL, i.e., physical symptoms, in everyday life of patients following HSCT. The present study addresses this gap by examining patient daily physical symptoms and their predictors in terms of demographic and clinical characteristics. METHODS: Physical symptoms were reported by 188 patients (56...
September 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28900823/health-related-quality-of-life-developmental-milestones-and-self-esteem-in-young-adults-with-bleeding-disorders
#19
P F Limperg, L Haverman, H Maurice-Stam, M Coppens, C Valk, M J H A Kruip, J Eikenboom, M Peters, M A Grootenhuis
BACKGROUND: The treatment of bleeding disorders improved in the last decades. However, the effect of growing up with bleeding disorders on developmental, emotional, and social aspects is understudied. Therefore, this study assesses HRQOL, developmental milestones, and self-esteem in Dutch young adults (YA) with bleeding disorders compared to peers. METHODS: Ninety-five YA (18-30 years) with bleeding disorders (78 men; mean 24.7 years, SD 3.5) and 17 women (mean 25...
September 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28899988/impact-of-incident-heart-failure-on-body-composition-over-time-in-the-health-aging-and-body-composition-study-population
#20
Daniel E Forman, Adam J Santanasto, Robert Boudreau, Tamara Harris, Alka M Kanaya, Suzanne Satterfield, Eleanor M Simonsick, Javed Butler, Jorge R Kizer, Anne B Newman
BACKGROUND: Prevalence of heart failure (HF) increases significantly with age, coinciding with age-related changes in body composition that are common and consequential. Still, body composition is rarely factored in routine HF care. METHODS AND RESULTS: The Health, Aging, and Body Composition study is a prospective cohort study of nondisabled adults. Using yearly dual-energy x-ray absorptiometry, body composition was assessed in the Health, Aging, and Body Composition study over 6 years, comparing those who developed incident HF versus those who did not...
September 2017: Circulation. Heart Failure
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