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https://www.readbyqxmd.com/read/28526765/factors-associated-with-ischemic-stroke-survival-and-recovery-in-older-adults
#1
Divya Thekkethala Winovich, William T Longstreth, Alice M Arnold, Ravi Varadhan, Adina Zeki Al Hazzouri, Mary Cushman, Anne B Newman, Michelle C Odden
BACKGROUND AND PURPOSE: Little is known about factors that predispose older adults to poor recovery after a stroke. In this study, we sought to evaluate prestroke measures of frailty and related factors as markers of vulnerability to poor outcomes after ischemic stroke. METHODS: In participants aged 65 to 99 years with incident ischemic strokes from the Cardiovascular Health Study, we evaluated the association of several risk factors (frailty, frailty components, C-reactive protein, interleukin-6, and cystatin C) assessed before stroke with stroke outcomes of survival, cognitive decline (≥5 points on Modified Mini-Mental State Examination), and activities of daily living decline (increase in limitations)...
May 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28525536/independent-and-differential-effects-of-obesity-and-hypertension-on-cognitive-and-functional-abilities
#2
Robert P Fellows, Maureen Schmitter-Edgecombe
Objective: The primary aim of this study was to identify the independent and differential associations of obesity and hypertension with cognitive, physical, and directly observed functional abilities among middle age and older adults. Method: Participants were 119 adults between the ages of 51 and 89, who underwent a cross-sectional assessment of cognitive, physical, functional and relevant health-related variables. Results: Obesity predicted significantly poorer executive functions (β = -...
May 19, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28523723/patient-characteristics-and-surgery-related-factors-associated-with-patient-reported-recovery-at-1-and-6%C3%A2-months-after-colorectal-cancer-surgery
#3
J Jakobsson, E Idvall, C Kumlien
Predictors for postoperative recovery after colorectal cancer surgery are usually investigated in relation to length of stay (LoS), readmission, or 30-day morbidity. This study describes patient characteristics and surgery-related factors associated with patient-reported recovery 1 and 6 months after surgery. In total, 153 consecutively included patients who were recovering from colorectal cancer surgery reported their level of recovery using the Postoperative Recovery Profile. Multiple logistic regression analysis was used to calculate associations with recovery, defined as good or poor, divided into five recovery dimensions: physical symptoms, physical functions, psychological, social and activity...
May 19, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28523721/a-prospective-study-of-quality-of-life-in-amyotrophic-lateral-sclerosis-patients
#4
B Jakobsson Larsson, A G Ozanne, K Nordin, I Nygren
OBJECTS: The aim of this prospective and longitudinal study was to describe individual quality of life in patients with amyotrophic lateral sclerosis (ALS) and its correlations with physical function and emotional well-being from diagnosis and over time. MATERIALS AND METHODS: Thirty-six patients were included in the study. Individual quality of life was measured with the Schedule of Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW), illness severity was assessed using the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALS FRS-R), and emotional distress was measured using the Hospital Anxiety and Depression Scale (HADS)...
May 19, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28523042/effect-of-conjugated-linoleic-acid-supplementation-on-quality-of-life-in-rectal-cancer-patients-undergoing-preoperative-chemoradiotherapy
#5
Elnaz Faramarzi, Reza Mahdavi, Mohammad Mohammad-Zadeh, Behnam Nasirimotlagh, Sarvin Sanaie
OBJECTIVES: This study set out with the aim of evaluating the effect of conjugated linoleic acid (CLA) supplementation on quality of life in rectal cancer patients undergoing to preoperative chemoradiotherapy. METHODS: In this study, 33 volunteer patients with rectal cancer treated with preoperative chemoradiotherapy were allocated in the CLA (n=16) and the placebo groups (n=17). The CLA group and placebo groups received 3 gr CLA/d and 4 placebo capsules for 6 weeks respectively...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521831/the-sitless-project-exercise-referral-schemes-enhanced-by-self-management-strategies-to-battle-sedentary-behaviour-in-older-adults-study-protocol-for-a-randomised-controlled-trial
#6
Maria Giné-Garriga, Laura Coll-Planas, Míriam Guerra, Àlex Domingo, Marta Roqué, Paolo Caserotti, Michael Denkinger, Dietrich Rothenbacher, Mark A Tully, Frank Kee, Emma McIntosh, Carme Martín-Borràs, Guillermo R Oviedo, Javier Jerez-Roig, Marta Santiago, Oriol Sansano, Guillermo Varela, Mathias Skjødt, Katharina Wirth, Dhayana Dallmeier, Jochen Klenk, Jason J Wilson, Nicole E Blackburn, Manuela Deidda, Guillaume Lefebvre, Denise González, Antoni Salvà
BACKGROUND: Older adults are the fastest growing segment of the world's population. Recent evidence indicates that excessive sitting time is harmful to health, independent of meeting the recommended moderate to vigorous physical activity (PA) guidelines. The SITLESS project aims to determine whether exercise referral schemes (ERS) can be enhanced by self-management strategies (SMSs) to reduce sedentary behaviour (SB), increase PA and improve health, quality of life and function in the long term, as well as psychosocial outcomes in community-dwelling older European citizens from four countries, within a three-armed pragmatic randomised controlled trial, compared with ERS alone and also with general recommendations about PA...
May 18, 2017: Trials
https://www.readbyqxmd.com/read/28518178/physical-function-and-exercise-training-in-older-patients-with-heart-failure
#7
REVIEW
Andrew J Stewart Coats, Daniel E Forman, Mark Haykowsky, Dalane W Kitzman, Amy McNeil, Tavis S Campbell, Ross Arena
Heart failure (HF) is a common end point for numerous cardiovascular conditions, including coronary artery disease, valvular disease, and hypertension. HF predominantly affects older individuals (aged ≥70 years), particularly those living in developed countries. The pathophysiological sequelae of HF progression have a substantial negative effect on physical function. Diminished physical function in older patients with HF, which is the result of combined disease-related and age-related effects, has important implications on health...
May 18, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28516877/validity-of-the-workers-productivity-and-activity-impairment-questionnaire-specific-health-problem-wpai-shp-in-patients-with-systemic-sclerosis
#8
Kathleen Morrisroe, Wendy Stevens, Molla Huq, Joanne Sahhar, Gene-Siew Ngian, Jane Zochling, Janet Roddy, Susanna M Proudman, Mandana Nikpour
OBJECTIVES: To evaluate the construct validity of the Workers Productivity and Impairment Activity Index: Specific Health Problem (WPAI:SHP) in Australian systemic sclerosis (SSc) patients. METHODS: SSc patients, identified through the Australian Scleroderma Cohort Study database, completed the WPAI:SHP and a quality of life instrument (PROMIS-29) cross-sectionally. The construct validity of the WPAI:SHP was assessed by the correlations between the WPAI:SHP and a range of SSc health states...
May 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516874/long-term-effects-of-interleukin-17a-inhibition-with-secukinumab-in-active-ankylosing-spondylitis-3-year-efficacy-and-safety-results-from-an-extension-of-the-phase-3-measure-1-trial
#9
Xenofon Baraliakos, Alan J Kivitz, Atul A Deodhar, Jürgen Braun, James C Wei, Eumorphia Maria Delicha, Zsolt Talloczy, Brian Porter
OBJECTIVES: Secukinumab, a fully human anti-IL-17A monoclonal antibody, provided rapid and sustained improvements in signs and symptoms of ankylosing spondylitis (AS) over 2 years in the Phase 3 MEASURE 1 trial. Here, we report efficacy and safety after 3 years of treatment. METHODS: AS subjects completing 2 years of treatment every 4 weeks with subcutaneous secukinumab 150 or 75 mg (following intravenous loading or initial placebo treatment to 16/24 weeks) entered a separate 3-year extension study (NCT01863732)...
May 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516810/the-role-of-meaning-in-life-mediating-the-effects-of-perceived-knowledge-of-stroke-on-depression-and-life-satisfaction-among-stroke-survivors
#10
Esther Ow Chow
OBJECTIVE: Meaning-making is a way of coping when facing adverse events. A paucity of literature suggests other possible factors (e.g. delivery of knowledge) can influence how chronic illness survivors (i.e. stroke survivors in rehabilitation) cope with illness. This article explores the importance and significance of meaning in life as a mediator between perceived stroke knowledge and psychological wellbeing among stroke survivors and how such processes can be applied in practice to promote their psychological wellbeing...
May 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28515070/even-mealtime-distribution-of-protein-intake-is-associated-with-greater-muscle-strength-but-not-with-3-y-physical-function-decline-in-free-living-older-adults-the-quebec-longitudinal-study-on-nutrition-as-a-determinant-of-successful-aging-nuage-study
#11
Samaneh Farsijani, Hélène Payette, José A Morais, Bryna Shatenstein, Pierrette Gaudreau, Stéphanie Chevalier
Background: Functional status declines with aging, thus impeding autonomy. Recently, a more even mealtime distribution of dietary protein was positively associated with muscle mass, but the relation of this distribution to physical performance remains unknown.Objective: We examined the relation between mealtime protein-intake distribution and physical performance and its 3-y decline in community-dwelling older adults.Design: Three-year follow-up data from 827 men and 914 women (67-84 y) in the longitudinal study on nutrition and aging [Quebec longitudinal study on Nutrition as a Determinant of Successful Aging (NuAge study); Quebec, Canada] were analyzed...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28514618/aerobic-or-resistance-exercise-or-both-in-dieting-obese-older-adults
#12
Dennis T Villareal, Lina Aguirre, A Burke Gurney, Debra L Waters, David R Sinacore, Elizabeth Colombo, Reina Armamento-Villareal, Clifford Qualls
BACKGROUND: Obesity causes frailty in older adults; however, weight loss might accelerate age-related loss of muscle and bone mass and resultant sarcopenia and osteopenia. METHODS: In this clinical trial involving 160 obese older adults, we evaluated the effectiveness of several exercise modes in reversing frailty and preventing reduction in muscle and bone mass induced by weight loss. Participants were randomly assigned to a weight-management program plus one of three exercise programs - aerobic training, resistance training, or combined aerobic and resistance training - or to a control group (no weight-management or exercise program)...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28514190/criterion-referenced-fitness-standards-associated-with-maintaining-functional-capacity-in-chilean-older-adults
#13
Eugenio Merellano-Navarro, Daniel Collado-Mateo, Javier García-Rubio, Narcís Gusi, Pedro R Olivares
The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels - that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. Cross-sectional study of 406 Chilean adults aged 60 and more. Functional capacity was measured via the Composite Physical Function scale (CPF). A battery of validated fitness tests for this population was used. Based on the results of the CPF, two variables were created: "advanced physical capacity" (defined as those scoring 24 on the CPF scale) and "moderate (independent) physical capacity," defined as those scoring between 14 and 23 on the CPF scale...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28513257/factors-associated-with-levels-of-physical-activity-in-chronic-kidney-disease-patients-undergoing-hemodialysis-the-role-of-dialysis-versus-non-dialysis-day
#14
Clara Suemi da Costa Rosa, Danilo Yuzo Nishimoto, Ismael Forte Freitas Júnior, Emmanuel Gomes Ciolac, Henrique Luiz Monteiro
BACKGROUND: patients on hemodialysis (HD) report lower physical activity (PA) levels. We analysed factors associated with low levels of PA in patients with chronic kidney disease (CKD) and compared PA on HD day and non-HD. METHODS: 79 patients wore an accelerometer and were classified according to time spent on moderate-vigorous PA (MVPA). Demographic data, BMI, comorbidities, clinical status and health related quality of life (HRQoL) were checked for association with PA...
May 17, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28512845/work-retirement-and-muscle-strength-loss-in-old-age
#15
Marco Bertoni, Stefania Maggi, Guglielmo Weber
Reduced muscle strength is an accurate predictor of functional limitations, disability, and mortality. Hence, understanding which socio-economic factors contribute to preserve muscle strength in old age is central to the design of social policies that help reducing these health risks. Using data on handgrip strength collected by the Survey of Health, Ageing and Retirement in Europe for the population of Europeans aged 50+ and the exogenous variation in pension eligibility age across countries over time, we estimate that the retirement transition has a short-term positive causal effect on muscle strength...
May 17, 2017: Health Economics
https://www.readbyqxmd.com/read/28512389/evaluation-of-quality-of-life-at-progression-in-patients-with-soft-tissue-sarcoma
#16
Stacie Hudgens, Anna Forsythe, Ilias Kontoudis, David D'Adamo, Ashley Bird, Hans Gelderblom
Introduction. Soft Tissue Sarcoma (STS) is a rare malignancy of mesodermal tissue, with international incidence estimates between 1.8 and 5 per 100,000 per year. Understanding quality of life (QoL) and the detrimental impact of disease progression is critical for long-term care and survival. Objectives. The primary objective was to explore the relationship between disease progression and health-related quality of life (HRQoL) using data from Eisai's study (E7389-G000-309). Methods. This was a 1 : 1 randomized, open-label, multicenter, Phase 3 study comparing the efficacy and safety of eribulin versus dacarbazine in patients with advanced STS...
2017: Sarcoma
https://www.readbyqxmd.com/read/28511689/harnessing-interactive-technologies-to-improve-health-outcomes-in-juvenile-idiopathic-arthritis
#17
REVIEW
Andrea Coda, Dean Sculley, Derek Santos, Xavier Girones, Lucie Brosseau, Derek R Smith, Joshua Burns, Keith Rome, Jane Munro, Davinder Singh-Grewal
BACKGROUND: Children and adolescents with Juvenile Idiopathic Arthritis (JIA) typically have reduced physical activity level and impaired aerobic and anaerobic exercise capacity when compared to their non-JIA counterparts. Low intensity exercise regimens appear to be safe in children with JIA and may results in improvements in overall physical function. Poor adherence to paediatric rheumatology treatment may lead to negative clinical outcomes and possibly increased disease activity. This includes symptoms such as pain, fatigue, quality of life, longer term outcomes including joint damage, as well as increase of healthcare associated costs...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28511639/physical-activity-among-hospitalized-older-adults-an-observational-study
#18
Sigurd Evensen, Olav Sletvold, Stian Lydersen, Kristin Taraldsen
BACKGROUND: Low level of physical activity is common among hospitalized older adults and is associated with worse prognosis. The aim of this paper is to describe the pattern and level of physical activity in a group of hospitalized older adults and to identify factors associated with physical activity. METHODS: We measured physical activity on day three after admission using accelerometer based activity monitors and time in upright position as outcome measure. We collected data of physical function (Short Physical Performance Battery, SPPB...
May 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28511288/a-tele-health-follow-up-strategy-for-tight-control-of-disease-activity-in-rheumatoid-arthritis-results-of-the-non-inferiority-randomised-controlled-trail-the-tera-study
#19
Annette Thurah, Kristian Stengaard-Pedersen, Mette Axelsen, Ulrich Fredberg, Liv M V Schougaard, Niels H I Hjollund, Mogens Pfeiffer-Jensen, Trine B Laurberg, Ulrik Tarp, Kirsten Lomborg, Thomas Maribo
OBJECTIVE: To test the effect of patient-reported outcome (PRO) based tele-health follow-up for tight control of disease activity in patients with rheumatoid arthritis (RA), and the differences between tele-health follow-up performed by rheumatologists or rheumatology nurses. METHODS: A total of 294 patients were randomized (1:1:1) to either PRO-based tele-health follow-up carried out by a nurse (PRO-TN) or a rheumatologist (PRO-TR), or conventional out-patient follow-up by physicians...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28509825/vascularized-pedicle-bone-grafting-from-the-cuboid-for-talar-osteonecrosis-results-of-a-novel-salvage-procedure
#20
James A Nunley, Kamran S Hamid
BACKGROUND: Osteonecrosis of the talar body represents a complex clinical challenge with treatment options currently limited to core decompression, vascularized and nonvascularized bone-grafting, total talar replacement, and hindfoot arthrodesis. Vascularized pedicle bone-grafting from the cuboid to the talus is a potential alternative to contemporary operative options for replacement of necrotic talar tissue with viable bone. We aimed to analyze functional and radiographic outcomes of vascularized pedicle bone-grafting from the cuboid for the treatment of talar osteonecrosis in a consecutive series of patients spanning a 12-year period...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
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