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Liver metastases chemotherapy

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https://www.readbyqxmd.com/read/29344248/survival-prediction-in-patients-with-resectable-colorectal-liver-metastases-clinical-risk-scores-and-tumor-response-to-chemotherapy
#1
Da Xu, Xiao-Feng Liu, Xiao-Luan Yan, Kun Wang, Bao-Cai Xing
Clinical risk scores and response to pre-operative chemotherapy are prognostic factors of colorectal liver metastases. The aim of the present study was to evaluate the effectiveness of combining these factors to predict patient survival and to select patients for curative therapy. The study included 189 patients who underwent hepatectomy following neo-adjuvant chemotherapy, for initially resectable colorectal liver metastases, between January 2005 and December 2015. Patients were stratified into four sub-groups: A1-2, low clinical risk scores with/without a response to pre-operative chemotherapy; and B1-2, high clinical risk scores with or without a response to pre-operative chemotherapy...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344141/the-expression-of-s100b-protein-in-serum-of-patients-with-brain-metastases-from-small-cell-lung-cancer-and-its-clinical-significance
#2
Shanling Mu, Hong Ma, Jun Shi, Dezhi Zhen
The objective of the present study was to investigate the expression of S100B protein in serum of patients with brain metastases from small cell lung cancer (SCLC), and its clinical significance. A total of 138 patients with SCLC were selected from June 2013 to December 2015. Simultaneously, 138 healthy adult volunteers (healthy controls) were selected in the medical examination center of People's Hospital of Rizhao. Among the 138 patients with SCLC, 48 had liver metastases and 44 had brain metastases. Of the remaining 46 patients, 20 were initially diagnosed with SCLC and 26 underwent surgery and postoperative chemotherapy...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29334610/phase-ii-study-of-dovitinib-in-patients-with-castration-resistant-prostate-cancer-kcsg-gu11-05
#3
Yoon Ji Choi, Hye Sook Kim, Se Hoon Park, Bong-Seog Kim, Kyoung Ha Kim, Hyo Jin Lee, Hong Suk Song, Dong-Yeop Shin, Ha Young Lee, Hoon-Gu Kim, Kyung Hee Lee, Jae Lyun Lee, Kyong Hwa Park
Purpose: Fibroblast growth factor (FGF) signals are important in carcinogenesis and progression of prostate cancer. Dovitinib is an oral, pan-class inhibitor of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor, and fibroblast growth factor receptor (FGFR). We evaluated the efficacy and toxicity of dovitinib in men with metastatic castration resistant prostate cancer (mCRPC). Materials and Methods: This study was a single-arm, phase II, open-label, multicenter trial of dovitinib 500mg/day (5-days-on/2-days-off schedule)...
January 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29333014/is-colorectal-cancer-in-young-40-years-different-from-those-in-the-elderly-40-years-experience-from-a-regional-care-center
#4
Rudresha A Haleshappa, Suparna Ajit Rao, Sunny Garg, C Lakshmaiah Kuntegowdanahalli, Govinda Babu Kanakasetty, Lokanatha Dasappa
Background: Colorectal cancer (CRC) is considered a disease of elderly. There has been a steady decrease in the incidence in those aged >50 years, with an alarming increase noted in adults aged <50 years. Subjects and Methods: We retrospectively analyzed 89 patients diagnosed with CRC aged <40 years between the years 2010 and 2014. Their clinical profile, treatment, and outcomes were studied. Results: The median age was 33 years with a male preponderance (56...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29324681/ppoma-review-epidemiology-aetiopathogenesis-prognosis-and-treatment
#5
REVIEW
Thais Ligiero Braga, Ralph Santos-Oliveira
Generally, pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma) is classified as a rare tumor, and may occur sporadically or be associated in families or with multiple endocrine neoplasia type 1 (NEM 1). It grows slowly, reaching large dimensions at the time of diagnosis and the symptomatology is fundamentally due to the mass effect, causing either non-specific abdominal pain or symptoms suggestive of obstruction of the pancreatic or biliary duct. Therefore, when detected, they are usually malignant, with metastases mainly in the liver...
January 11, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29304822/significance-of-poor-performance-status-after-resection-of-colorectal-liver-metastases
#6
Peter Strandberg Holka, Sam Eriksson, Jakob Eberhard, Magnus Bergenfeldt, Gert Lindell, Christian Sturesson
BACKGROUND: Performance status (PS) is known as one of the strongest prognostic factors for survival in metastatic colorectal cancer patients. The aim of the present study was to analyze factors associated with poor PS assessed after resection for colorectal liver metastases and the impact on survival. METHODS: All patients undergoing curative resection for colorectal liver metastases between 2010 and 2015 in a single center were reviewed retrospectively. RESULTS: A total of 284 patients were included, out of whom 74 patients (26%) presented with a postoperative PS WHO > 2 precluding administration of adjuvant chemotherapy...
January 5, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29299827/apical-lymph-nodes-in-the-distant-metastases-and-prognosis-of-patients-with-stage-iii-colorectal-cancer-with-adequate-lymph-node-retrieval-following-folfox-adjuvant-chemotherapy
#7
Hsiang-Lin Tsai, Yi-Ting Chen, Yung-Sung Yeh, Ching-Wen Huang, Cheng-Jen Ma, Jaw-Yuan Wang
The aim of the study was to assess apical lymph nodes (APNs) for predicting distant metastases in patients with stage III colorectal cancer (CRC) curatively treated with FOLFOX adjuvant chemotherapy and adequate lymph node retrieval. We investigated the correlation between APN metastasis and clinical outcomes. This retrospective study examined 97 patients. All patients were followed until death, loss to follow-up, or May 2017. Clinicopathological variables, including the APN status, were assessed. Multivariate logistic regression model was used to identify the independent risk factors for APN and distant metastases, and Cox proportional regression model was used to evaluate the association between APN metastasis and oncologic outcomes...
January 3, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29299375/radiation-generates-an-abscopal-response-and-complete-resolution-of-metastatic-squamous-cell-carcinoma-of-the-anal-canal-a-case-report
#8
Moss Bruton Joe, Julian J Lum, Peter H Watson, R Petter Tonseth, John Paul McGhie, Pauline T Truong
The abscopal effect is a rare phenomenon in the setting of radiation therapy (RT) for metastatic cancer where tumor regression occurs distant from the site of treatment. A proposed mechanism of the abscopal effect is the activation of a systemic antitumor immune response by localized RT. We report the first case, to our knowledge, of the abscopal effect in squamous carcinoma of the anal canal with metastases to pelvic lymph nodes, liver and bone. After palliative RT to the pelvis with sensitizing chemotherapy, complete response was observed not only in the primary tumor but also in bone and multiple liver metastases at 4 months after treatment, an effect that remained durable at 4-year follow-up...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290599/hepatic-arterial-infusion-in-the-management-of-colorectal-cancer-liver-metastasis-current-and-future-perspectives
#9
REVIEW
Nicolas Chapelle, Tamara Matysiak-Budnik, Frédéric Douane, Sylvie Metairie, Philippe Rougier, Yann Touchefeu
The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases from colorectal cancer has been developed over more than 30 years. Although the indications and protocols for this technique have evolved with time, HAI is not routinely performed in clinical practice. Studies have been heterogeneous, with different regimens of intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing outcomes. Technical difficulties for catheter placement have limited the implementation of this method in routine practice...
December 14, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29285651/a-long-term-survival-case-treated-with-conversion-surgery-following-chemotherapy-after-diagnostic-metastasectomy-for-pancreatic-cancer-with-synchronous-liver-metastasis
#10
Mitsuhiro Shimura, Masamichi Mizuma, Hiroki Hayashi, Akiko Mori, Tomoyoshi Tachibana, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Kyohei Ariake, Shimpei Maeda, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Takeshi Naitoh, Takashi Kamei, Fuyuhiko Motoi, Michiaki Unno
BACKGROUND: Pancreatic cancer with distant metastases is classified as "unresectable," for which the standard treatment is systemic chemotherapy. The effectiveness of radical resection for pancreatic cancer with distant metastases is unknown. Here, we report a case of long term survival treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis. CASE PRESENTATION: A 73-year-old man was referred to our hospital to examine and treat for cancer of the pancreatic body...
December 29, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29281902/treatment-of-uterine-sarcoma-with-rad-p53-gendicine%C3%A2-followed-by-chemotherapy-clinical-study-on-tp53-gene-therapy
#11
Yu Xia, Zhenhua Du, Xinyan Wang, Xiuqin Li
AIM: The purpose of this study was to evaluate the efficacy of rAd-p53 (Gendicine®) followed by chemotherapy in the treatment of uterine sarcoma. METHODS: Retrospective analysis of the 12 cases of uterine sarcoma in Shengjing hospital. Among the 12 patients, 1 suffered from primary cancer and 11 suffered from recurrent cancer. The interval between the first operation and the diagnosis of recurrence of 11 cases, PFS1 (Progression-Free Survival time1) was 1-18 months (median 3 months)...
December 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29259378/impact-of-homogeneous-pathologic-response-to-preoperative-chemotherapy-in-patients-with-multiple-colorectal-liver-metastases
#12
Charles Sabbagh, Denis Chatelain, Christophe Attencourt, Jean-Paul Joly, Bruno Chauffert, Cyril Cosse, Jean-Marc Regimbeau
AIM: To analyze the homogeneity of pathologic response to preoperative chemotherapy (PRPC) after chemotherapy in patients with multiple liver metastases (LM). METHODS: From September 2011 to August 2014, patients with at least two LM undergoing preoperative chemotherapy prior to resection were included in this retrospective, single-center study. The endpoints were PRPC homogeneity (according to both the Rubbia-Brandt and MD Anderson classifications), the impact of PRPC on the MDT decision, factors associated with homogeneous PRPC and overall survival of patients with vs...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29250695/adenocarcinoma-versus-pancreatic-neuroendocrine-tumor-case-report
#13
Dana Lucia Stănculeanu, Carmen Maria Ardeleanu, Daniela LuminiŢa Zob, Raluca Ioana Mihăilă, Oana Cătălina Toma, LaurenŢiu Simion, Puiu Olivian Stovicek, Michael Schenker
Pancreatic cancer represents one of the most aggressive types of cancer, resulting in a late diagnosis and rapid death (poor overall survival). After adenocarcinoma (counting almost 80% of cases of pancreatic cancer), the second category, as frequency, is represented by the family of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Pancreatic cancer is characterized by genetic heterogeneity and may results in different evolution among metastases, which may acquire driver mutations with the ability to transform under the action of several cancer treatments...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29248834/cerebellar-metastasis-of-gastrointestinal-stromal-tumor-a-case-report-and-review-of-the-literature
#14
Mohamed Badri, Mohamed Chabaane, Ghassen Gader, Kamel Bahri, Ihsen Zammel
INTRODUCTION: Intracranial metastases of gastro intestinal tumors are very rare. To the best of our knowledge only few cases were reported on the literature. CASE DESCRIPTION: We describe the case of 66-year-old male that presented with headache and vomiting. Physical examination found a kinetic cerebellar syndrome. Brain CT scan and MRI showed a right cerebellar tumor. Sub-occipital craniotomy was performed and the tumor was completely resected. Surgical outcomes were marked by the occurrence of an abdominal pain two days after brain surgery...
December 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29246174/changes-of-liver-hemodynamic-and-elastography-parameters-in-patients-with-colorectal-liver-metastases-receiving-preoperative-chemotherapy-a-note-of-caution
#15
Amalia Pelegrina, Josep Martí, Rosa Miquel, Joana Ferrer, Virginia Hernández-Gea, Alba Diaz, Cristina Nadal, Juan Carlos García-Valdecasas, Josep Fuster
BACKGROUND: New systemic chemotherapy agents have improved prognosis in patients with colorectal liver metastases (CLM), but some of them damage the liver parenchyma and ultimately increase postoperative morbidity and mortality after liver resection. The aims of our study were to determine the degree of hemodynamic and pathological liver injury in CLM patients receiving preoperative chemotherapy and to identify an association between these injuries and postoperative complications after liver resection...
December 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29245346/two-independent-incidences-of-skin-metastases-in-the-umbilicus-and-abdominal-wall-in-ovarian-serous-adenocarcinoma-a-case-report-and-review-of-the-literature
#16
Hongyan Cheng, Chunmei Gao, Runtong Zhang, Zhaojie Yang, Guiyu Zhang
RATIONALE: Advanced ovarian cancer is usually associated with intra-abdominal metastases and while it commonly spreads directly to the omentum, intestine, liver, or other organs, it can also metastasize through the lymphatic channels and the hematogenous pathway. With an increasing number of invasive operations being performed with chemoradiotherapy, the incidence of extra-abdominal metastases has risen. Nevertheless, ovarian cancer with skin metastases is quite rare. PATIENT CONCERNS: We report a case of ovarian cancer with two independent incidences of skin metastases in the umbilicus and abdominal wall...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245278/tonsillar-metastasis-of-nonsmall-cell-lung-cancer-with-g719s-mutation-in-exon-18-a-case-report
#17
Yimin Wu, Zhouyu Zhu, Yongyuan Chen, Ying Chai
RATIONALE: Lung cancer has the highest mortality of all malignant tumors and is becoming the leading cause of death in China. Surgical resection is the best treatment for early non-small-cell lung carcinoma. But postoperative tumor recurrence is very common. Brain, bone and liver are the most common metastatic sites of lung cancer. PATIENT CONCERNS: A 59-year-old woman was admitted to our hospital finding a lung nodule in physical examination. No other obvious symptoms were obsessed in this patient...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245237/a-rare-case-of-angiosarcoma-with-skull-masses-and-erythropenia-and-thrombocytopenia-a-case-report-and-review-of-literature
#18
Liansheng Gao, Weilin Xu, Tao Li, Huali Luo, Shiying Gai, Ruxin Xing, Gao Chen, Yili Chen
RATIONALE: Primary splenic angiosarcoma (PSA) is a rare, fatal neoplasm originating from sinusoidal vascular endothelial cells, and usually metastasizes and almost always has a poor prognosis. Surgical excision is the main treatment of this highly malignant disease. PATIENT CONCERNS: We reported a special case of a 68-year-old female who had a 6-month history of scalp masses. DIAGNOSIS: The patient was found to have 2 skull masses on computed tomography (CT)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242966/cyp1a1-genetic-polymorphism-is-a-promising-predictor-to-improve-chemotherapy-effects-in-patients-with-metastatic-breast-cancer-treated-with-docetaxel-plus-thiotepa-vs-docetaxel-plus-capecitabine
#19
Xinna Zhou, Guoliang Qiao, Xiaoli Wang, Qingkun Song, Michael A Morse, Amy Hobeika, William R Gwin, Jun Ren, H Kim Lyerly
PURPOSE: A prospective study was performed to compare the outcome for metastatic breast cancer (MBC) patients treated with docetaxel plus thiotepa (DT) or docetaxel plus capecitabine (DC), and to explore the value of CYP1A1*2C polymorphisms in predicting clinical efficacy of these chemotherapies. METHODS: MBC patients (n = 130) were randomized to treatment with DT (n = 65) or DC (n = 65). Response rate, disease control rate, progression-free and overall survival were monitored...
December 14, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29235221/liver-transplant-for-metastatic-pancreatoblastoma-7-year-event-free-survival-after-chemotherapy-pancreatectomy-complete-hepatectomy-and-liver-transplant
#20
A A Ghaffarian, L Book, R L Meyers
Pancreatoblastoma is a rare malignant tumor in children. Surgical resection of the tumor is necessary for cure; however, due to its aggressive nature, it is often unresectable at presentation due to tumor size, local invasion, and/or metastasis. Because it is a rare tumor, there is currently no standard treatment regimen. We report a case of a 4-year-old boy who presented with metastatic pancreatoblastoma with multiple large metastases involving all four sectors of the liver. We began treatment with chemotherapy (cisplatin, 5FU, vincristine, and doxorubicin), which significantly reduced the tumor burden in both the pancreas and liver...
December 13, 2017: Pediatric Transplantation
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