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https://www.readbyqxmd.com/read/28529743/omental-synovial-sarcoma-mimicking-an-ovarian-malignancy-a-case-report
#1
Naoyuki Iwahashi, Yoko Deguchi, Yuko Horiuchi, Kazuhiko Ino, Kenichi Furukawa
Synovial sarcoma is clinically rare, and cases of synovial sarcoma arising in the omentum are particularly rare. Only 3 cases have been reported in the literature to dtae, and they were associated with a poor prognosis. We herein report a rare case of aggressive primary omental synovial sarcoma presenting as an ovarian malignancy. A 53-year-old multigravida woman was referred to our hospital due to progressive abdominal distension. Magnetic resonance imaging revealed a large heterogeneous mass with an irregular component occupying the lower abdominal cavity, with an intact uterus...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529719/contemporary-surgical-management-of-synchronous-colorectal-liver-metastases
#2
REVIEW
Danielle Collins, Heidi Chua
Historically, the 5-year survival rates for patients with stage 4 (metastatic) colorectal cancer were extremely poor (5%); however, with advances in systemic chemotherapy combined with an ability to push the boundaries of surgical resection, survival rates in the range of 25-40% can be achieved. This multimodal approach of combining neo-adjuvant strategies with surgical resection has raised a number of questions regarding the optimal management and timing of surgery. For the purpose of this review, we will focus on the treatment of stage 4 colorectal cancer with synchronous liver metastases...
2017: F1000Research
https://www.readbyqxmd.com/read/28524826/prognostic-analysis-of-102-patients-with-synchronous-colorectal-cancer-and-liver-metastases-treated-with-simultaneous-resection
#3
Ye-Fan Zhang, Rui Mao, Xiao Chen, Jian-Jun Zhao, Xin-Yu Bi, Zhi-Yu Li, Jian-Guo Zhou, Hong Zhao, Zhen Huang, Yong-Kun Sun, Jian-Qiang Cai
BACKGROUND: The liver is the most common site for colorectal cancer (CRC) metastases. Their removal is a critical and challenging aspect of CRC treatment. We investigated the prognosis and risk factors of patients with CRC and liver metastases (CRCLM) who underwent simultaneous resections for both lesions. METHODS: From January 2009 to August 2016, 102 patients with CRCLM received simultaneous resections of CRCLM at our hospital. We retrospectively analyzed their clinical data and analyzed their outcomes...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28523316/fibrolamellar-hepatocellular-carcinoma-with-ovarian-metastasis-an-unusual-presentation
#4
Silviu Horia Ciurea, Emil Matei, CodruŢ Silvian Stănescu, Ioana Gabriela Lupescu, Mirela Boroş, Vlad Herlea, Niculina Ioana Luca, Bogdan Mihail DorobanŢu
AIM: Fibrolamellar carcinoma (FLC) has been considered a distinct clinical entity vs. hepatocellular carcinoma, with respect to its epidemiology, etiology, and prognosis. CASE PRESENTATION: We describe the unusual case of a 23-year-old female patient with FLC and ovarian (Krukenberg) and peritoneal metastases, clinically mimicking an ovarian carcinoma. Multiple recurrences occurred despite initial R0 resection and chemotherapy, requiring surgical treatment. The patient survived five years and died from generalized disease...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28522174/results-after-surgical-treatment-of-liver-metastases-in-patients-with-high-grade-gastroenteropancreatic-neuroendocrine-carcinomas
#5
R B Galleberg, U Knigge, E Tiensuu Janson, L W Vestermark, S-P Haugvik, M Ladekarl, S W Langer, H Grønbæk, P Österlund, G O Hjortland, J Assmus, L Tang, A Perren, H Sorbye
BACKGROUND: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. METHODS: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries...
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28521471/preoperative-peripheral-blood-neutrophil-count-predicts-long-term-outcomes-following-hepatic-resection-for-colorectal-liver-metastases
#6
Koichiro Haruki, Hiroaki Shiba, Yuki Fujiwara, Kenei Furukawa, Tomonori Iida, Masahisa Ohkuma, Masaichi Ogawa, Yuichi Ishida, Takeyuki Misawa, Katsuhiko Yanaga
Preoperative systemic inflammatory response is associated with a poor long-term prognosis following resection surgery for malignant tumors. Several markers of systemic inflammation have been reported to be associated with the outcome; however, they have not currently been fully investigated. Therefore, the association between preoperative peripheral blood neutrophil count and oncological outcome following hepatic resection for colorectal liver metastasis (CRLM) was retrospectively investigated. The present study comprised 89 patients who had undergone hepatic resection for CRLM between January 2000 and March 2010...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28516292/limax-test-improves-diagnosis-of-chemotherapy-associated-liver-injury-before-resection-of-colorectal-liver-metastases
#7
Johan F Lock, Tilman Westphal, Tom Rubin, Maciej Malinowski, Antje Schulz, Maximilian Jara, Jan Bednarsch, Martin Stockmann
BACKGROUND: Chemotherapy of colorectal liver metastases (CLMs) prior to liver resection implies the risk of chemotherapy-associated liver injury, leading to increased postoperative morbidity and mortality OBJECTIVE: The aim of this study was to evaluate the LiMAx (liver maximum capacity) test for diagnosis of chemotherapy-associated liver injury. METHODS: This was a retrospective analysis of patients with CLMs, prior to liver resection. We performed preoperative assessment of liver function using biochemical parameters and the LiMAx test...
May 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28515916/ecog-is-as-independent-predictor-of-the-response-to-chemotherapy-overall-survival-and-progression-free-survival-in-carcinoma-of-unknown-primary-site
#8
Rocío Grajales-Álvarez, Ana Martin-Aguilar, Juan A Silva, Jaime G De La Garza-Salazar, Erika Ruiz-García, César López-Camarillo, Laurence A Marchat, Horacio Astudillo-De La Vega
The aim of the present study was to determine whether age, gender, functional status, histology, tumor location, number of metastases, and levels of the tumor markers, lactate dehydrogenase (LDH) and albumin, are poor prognostic factors for the response to chemotherapy in patients with carcinoma of unknown primary site. A total of 149 patients diagnosed with carcinoma of unknown primary site that was histologically confirmed, and treated with chemotherapy in the Oncology Hospital, National Medical Center, 'Century XXI' IMSS, Mexico City, Mexico during the period between January 2002 to December 2009, were carefully selected for the present study...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28511265/diagnostic-value-of-diffusion-weighted-mri-for-tumor-characterization-differentiation-and-monitoring-in-pediatric-patients-with-neuroblastic-tumors
#9
Henning Neubauer, Mengxia Li, Verena Rabea Müller, Thomas Pabst, Meinrad Beer
Purpose We explored the diagnostic value of diffusion-weighted MRI (DWI) for tumor characterization, differentiation and therapy monitoring in pediatric patients with extracranial neuroblastic tumors. Materials and Methods All 29 patients (14 girls, median age: 3 years) with neuroblastoma (NB, n = 19), ganglioneuroblastoma (GNB, n = 4) and ganglioneuroma (GN, n = 6) who had had at least one in-house DWI examination since 2005 were identified and retrospectively analyzed. Two independent blinded readers measured ADC values (unit: 10-3 mm(2)/s) and signal intensity ratios (SIRs) of the primary tumor and, if applicable, of the tumor after chemotherapy, metastases and tumor relapse...
May 16, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28510992/lymph-node-effective-vascular-permeability-and-chemotherapy-uptake
#10
Eelco Fj Meijer, Cedric Blatter, Ivy X Chen, Echoe Bouta, Dennis Jones, Ethel R Pereira, Keehoon Jung, Benjamin J Vakoc, James W Baish, Timothy P Padera
OBJECTIVE: Lymph node metastases are a poor prognostic factor. Additionally, responses of lymph node metastasis to therapy can be different from the primary tumor. Investigating the physiologic lymph node blood vasculature might give insight into the ability of systemic drugs to penetrate the lymph node, and thus into the differential effect of therapy between lymph node metastasis and primary tumors. Here, we measured effective vascular permeability of lymph node blood vessels and attempted to increase chemotherapy penetration by increasing effective vascular permeability...
May 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28508848/recurrent-osteosarcoma-with-calcified-liver-metastases-uncommon-development-of-a-common-disease
#11
Shikha Goyal, Pramod K Julka
Osteosarcoma is the commonest primary malignant bone tumor. Since bones lack a lymphatic system, metastatic spread in these tumors is exclusively hematogenous, the commonest sites being lungs and bone. We report a case of osteosarcoma humerus which recurred locally after primary therapy consisting of neoadjuvant chemotherapy and limb salvage surgery, who developed calcified liver metastases in addition to local and pulmonary relapse. Liver, though a common site of hematogenous spread in most solid tumors, has rarely been reported to be involved in metastatic osteosarcomas...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28508838/randomized-controlled-phase-iii-study-comparing-hepatic-arterial-infusion-with-systemic-chemotherapy-after-curative-resection-for-liver-metastasis-of-colorectal-carcinoma-jfmc-29-0003
#12
Mitsuo Kusano, Michitaka Honda, Koji Okabayashi, Koho Akimaru, Syuichi Kino, Yasushige Tsuji, Masashi Watanabe, Satoshi Suzuki, Takaki Yoshikawa, Junichi Sakamoto, Koji Oba, Shigetoyo Saji
BACKGROUND: The feasibility and efficacy of adjuvant hepatic arterial infusion (HAI) in preventing the development of liver metastases in patients with advanced colon carcinoma have not been validated. The aim of this randomized controlled study was to compare the feasibility of HAI and the protective effect against liver metastasis after curative resection to those of systemic chemotherapy. METHODS: Between July 2000 and June 2003, 91 patients were enrolled. Patients were randomly assigned to receive 5-fluorouracil (5-FU) via continuous venous infusion (CVI) or intra-hepatic arterial weekly high-dose 5-FU (WHF)...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28495437/case-controlled-study-comparing-peri-operative-and-cancer-related-outcomes-after-major-hepatectomy-and-parenchymal-sparing-hepatectomy-for-metastatic-colorectal-cancer
#13
Jeffrey T Lordan, John K Roberts, James Hodson, John Isaac, Paolo Muiesan, Darius F Mirza, Ravi Marudanayagam, Robert P Sutcliffe
INTRODUCTION: Liver resection is potentially curative in selected patients with colorectal liver metastases (CLM). There has been a trend towards parenchyma sparing hepatectomy (PSH) rather than major hepatectomy (MH) due to lower perioperative morbidity. Although data from retrospective series suggest that long-term survival after PSM are similar to MH, these reports may be subject to selection bias. The aim of this study was to compare outcomes of PSH and MH in a case-controlled study...
May 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28493838/efficacy-and-safety-of-nimotuzumab-with-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-for-locoregionally-advanced-nasopharyngeal-carcinoma
#14
Fangzheng Wang, Chuner Jiang, Zhimin Ye, Quanquan Sun, Tongxin Liu, Min Xu, Peng Wu, Kaiyuan Shi, Bin Long, Aizawa Rihito, Sakamoto Masoto, Zhenfu Fu
We assessed the efficacy and safety of nimotuzumab plus neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for Chinese patients with locoregionally advanced nasopharyngeal carcinoma. Clinical data from 210 nonmetastatic nasopharyngeal carcinoma patients diagnosed between May 2008 and April 2014 were retrospectively reviewed. All patients were initially treated with nimotuzumab plus neoadjuvant chemotherapy followed by concurrent chemoradiotherapy. Ninety-five patients received cisplatin-based adjuvant chemotherapy...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493097/gastric-adenosquamous-carcinoma-producing-granulocyte-colony-stimulating-factor-a-case-of-a-rare-malignancy
#15
Kazuki Moro, Masayuki Nagahashi, Tetsuya Naito, Yu Nagai, Tomohiro Katada, Masahiro Minagawa, Jun Hasegawa, Tatsuo Tani, Naohiro Shimakage, Hiroyuki Usuda, Emmanuel Gabriel, Tsutomu Kawaguchi, Kazuaki Takabe, Toshifumi Wakai
BACKGROUND: A gastric adenosquamous carcinoma (ASC) that produces granulocyte-colony stimulating factor (G-CSF) is an uncommon malignancy with a poor prognosis. Due to the rarity of this lesion, a standard treatment for the disease has not been established. CASE PRESENTATION: We describe a case of a 66-year-old male with a G-CSF-producing gastric ASC who presented with severe anemia and leukocytosis. A radical resection was performed, followed by a course of adjuvant chemotherapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28490991/other-non-surgical-treatments-for-liver-cancer
#16
Paul Revel-Mouroz, Philippe Otal, Marion Jaffro, Antoine Petermann, Olivier Meyrignac, Pierre Rabinel, Fatima-Zohra Mokrane
Interventional radiology plays a major role in the modern management of liver cancers, in primary hepatic malignancies or metastases and in palliative or curative situations. Radiological treatments are divided in two categories based on their approach: endovascular treatment and direct transcapsular access. Endovascular treatments include mainly three applications: transarterial chemoembolization (TACE), transarterial radioembolization (TARE) and portal vein embolization (PVE). TACE and TARE share an endovascular arterial approach, consisting of a selective catheterization of the hepatic artery or its branches...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28480077/combined-dabrafenib-and-trametinib-treatment-in-a-case-of-chemotherapy-refractory-extrahepatic-braf-v600e-mutant-cholangiocarcinoma-dramatic-clinical-and-radiological-response-with-a-confusing-synchronic-new-liver-lesion
#17
Judit Kocsis, Anita Árokszállási, Csilla András, Ingrid Balogh, Edit Béres, Júlia Déri, István Peták, Levente Jánváry, Zsolt Horváth
Since the prognosis of advanced cholangiocarcinoma (CCA) remains poor with traditional chemotherapy, attention has shifted to molecularly targeted agents. Results of available clinical studies reveal little or no benefit of using targeted agents in advanced CCA. Limitations of these trials could be the lack of comprehensive molecular and genetic characterization of CCA samples in order to identify potential drug targets. Here we report a case of a 59-year-old female with chemotherapy-refractor, metastatic extrahepatic cholangiocarcinoma (EHCCA)...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28473088/acr-appropriateness-criteria-%C3%A2-suspected-liver%C3%A2-metastases
#18
Harmeet Kaur, Nicole M Hindman, Waddah B Al-Refaie, Hina Arif-Tiwari, Brooks D Cash, Victoria Chernyak, James Farrell, Joseph R Grajo, Jeanne M Horowitz, Michelle M McNamara, Richard B Noto, Aliya Qayyum, Tasneem Lalani, Ihab R Kamel
Liver metastases are the most common malignant liver tumors. The accurate and early detection and characterization of liver lesions is the key to successful treatment strategies. Increasingly, surgical resection in combination with chemotherapy is effective in significantly improving survival if all metastases are successfully resected. MRI and multiphase CT are the primary imaging modalities in the assessment of liver metastasis, with the relative preference toward multiphase CT or MRI depending upon the clinical setting (ie, surveillance or presurgical planning)...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28471829/epidemiology-of-pancreatic-cancer-in-france-descriptive-study-from-the-french-national-hospital-database
#19
Frédérique Maire, Jean-Olivier Cibot, Catherine Compagne, Olivia Hentic, Pascal Hammel, Nelly Muller, Philippe Ponsot, Philippe Levy, Philippe Ruszniewski
INTRODUCTION: Although indirect evidence suggests that the incidence of pancreatic adenocarcinoma has increased in the last decade, few data are available in European countries. The aim of the present study was to update the epidemiology of pancreatic cancer in France in 2014 from the French national hospital database (Programme de Médicalisation des Systèmes d'Information). PATIENTS AND METHODS: All patients hospitalized for pancreatic cancer in France in 2014 in public or private institutions were included...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28469358/the-value-of-staging-laparoscopy-in-gastric-cancer
#20
REVIEW
Nikolaos Machairas, Petros Charalampoudis, Ernesto P Molmenti, Stylianos Kykalos, Peter Tsaparas, Paraskevas Stamopoulos, Georgios C Sotiropoulos
Treatment options for patients with gastric cancer (GC) are based on tumor staging and resectability. Although only surgery provides improved survival, resection is contraindicated and should be avoided in the presence of intra-abdominal disease stage M1 (liver, peritoneal, or non-local lymph node metastases). Thus, a detailed and precise evaluation is imperative for optimal treatment. Staging laparoscopy (SL) constitutes a major tool in the accurate diagnosis of several types of cancers, including GC. SL presents several critical advantages: it can diagnose intra-abdominal disease; serve as a complement to other imaging studies; allow for biopsies; facilitate intraoperative ultrasound evaluations; allow for sampling of peritoneal fluid for cytological examination; and serve as an option for the administration of intraperitoneal chemotherapy...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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