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Liver metastases chemotherapy

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https://www.readbyqxmd.com/read/28717913/survival-benefits-of-surgical-resection-in-patients-with-recurrent-biliary-tract-carcinoma
#1
Hiroaki Motoyama, Akira Kobayashi, Takahide Yokoyama, Akira Shimizu, Noriyuki Kitagawa, Tsuyoshi Notake, Kentaro Fukushima, Hitoshi Masuo, Takahiro Yoshizawa, Shin-Ichi Miyagawa
BACKGROUND: Whether surgical resection for recurrent biliary tract carcinoma (BTC) prolongs survival and the patients who are most likely to benefit from such treatment remain unclear. METHODS: Among 251 patients with recurrences after the initial resection of BTC, a total of 21 patients (8.4%) underwent surgical resection for the recurrence, with a zero mortality rate. The clinicopathological features of these patients were compared with those of patients who did not undergo surgery...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717739/liver-metastasectomy-and-systemic-therapy-improve-overall-survival-compared-with-surgery-alone-after-curative-liver-resection-of-colorectal-metastases-in-a-developing-country-costa-rica
#2
Paula Quesada-Soto, Denis Landaverde, Allan Ramos-Esquivel
BACKGROUND: Resection of liver-isolated metastases of colorectal cancer (CRC) offers the greatest likelihood of cure. Nevertheless, recurrence rates after this procedure are high, and chemotherapy is a reasonable choice with inconclusive evidence. We aimed to determine if there is a survival difference between patients receiving systemic therapy with surgery versus surgery alone for resection of liver metastases. METHODS: From a source population of 170 patients treated in our National Centre (Centro Nacional de Cirugía Hepatobiliar, San José, Costa Rica), with liver metastases from various primary sites, we selected 51 patients with CRC who underwent hepatic resection with curative intent...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28712693/diagnostic-performance-of-contrast-enhanced-ct-scan-in-sinusoidal-obstruction-syndrome-induced-by-chemotherapy-of-colorectal-liver-metastases-radio-pathological-correlation
#3
Sophie Cayet, Jeremy Pasco, Fanny Dujardin, Marie Besson, Isabelle Orain, Anne De Muret, Elodie Miquelestorena-Standley, Julien Thiery, Thibaud Genet, Anne-Gwenn Le Bayon
PURPOSE: Sinusoidal obstruction syndrome (SOS) is a likely side effect of colorectal liver metastases (CRLM) chemotherapy. This study aimed to assess computed tomography scan (CT-scan) performance for SOS diagnosis for patients receiving neoadjuvant chemotherapy (NC) prior to CRLM surgery, comparing obtained results with pathological gold standard. METHODS: Preoperative CT-scans of 67 patients who had received a NC prior to liver resection for CRLM from 2011 to 2016 were retrospectively analysed...
July 3, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28709876/is-cure-possible-after-sequential-resection-of-hepatic-and-pulmonary-metastases-from-colorectal-cancer
#4
Muthukumarassamy Rajakannu, Pierre Magdeleinat, Eric Vibert, Oriana Ciacio, Gabriella Pittau, Pasquale Innominato, Antonio SaCunha, Daniel Cherqui, Jean-François Morère, Denis Castaing, René Adam
BACKGROUND: Surgical resection is an established therapeutic strategy for colorectal cancer (CRC) metastasis. However, controversies exist when CRC liver and lung metastases (CLLMs) are found concomitantly or when recurrence develops after either liver or lung resection. No predictive score model is available to risk stratify these patients in preparation for surgery, and cure has not yet been reported. PATIENTS AND METHODS: All consecutive patients who had undergone surgery for CLLMs at our institution during a 20-year period were reviewed...
June 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28695424/flt-pet-for-early-response-evaluation-of-colorectal-cancer-patients-with-liver-metastases-a-prospective-study
#5
Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind, Andreas Kjaer
BACKGROUND: Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study was to evaluate whether FLT-PET can be used for the early evaluation of treatment response in colorectal cancer patients (CRC) with liver metastases. Patients with metastatic CRC having at least one measurable (>1 cm) liver metastasis receiving first-line chemotherapy were included...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28692036/neoadjuvant-chemotherapy-affects-molecular-classification-of-colorectal-tumors
#6
K Trumpi, I Ubink, A Trinh, M Djafarihamedani, J M Jongen, K M Govaert, S G Elias, S R van Hooff, J P Medema, M M Lacle, L Vermeulen, I H M Borel Rinkes, O Kranenburg
The recent discovery of 'molecular subtypes' in human primary colorectal cancer has revealed correlations between subtype, propensity to metastasize and response to therapy. It is currently not known whether the molecular tumor subtype is maintained after distant spread. If this is the case, molecular subtyping of the primary tumor could guide subtype-targeted therapy of metastatic disease. In this study, we classified paired samples of primary colorectal carcinomas and their corresponding liver metastases (n=129) as epithelial-like or mesenchymal-like, using a recently developed immunohistochemistry-based classification tool...
July 10, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28688518/neutrophil-to-lymphocyte-ratio-predicts-prognosis-after-neoadjuvant-chemotherapy-and-resection-of-intrahepatic-cholangiocarcinoma
#7
Kiyohiko Omichi, Jordan M Cloyd, Suguru Yamashita, Ching-Wei D Tzeng, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Previous studies have demonstrated a strong association between the preoperative neutrophil-to-lymphocyte ratio and the outcomes of patients with resected hepatocellular carcinoma and colorectal liver metastases. However, the predictive ability of neutrophil-to-lymphocyte ratio in patients with intrahepatic cholangiocarcinoma, especially those treated with preoperative chemotherapy, has been less well described. METHODS: The clinicopathological characteristics, overall survival, and recurrence free survival of all patients with intrahepatic cholangiocarcinoma resected between 2000-2015, were compared between those with elevated (≥3...
July 5, 2017: Surgery
https://www.readbyqxmd.com/read/28687256/improved-survival-with-palliative-surgery-and-chemotherapy-for-mixed-adenoneuroendocrine-carcinoma-of-the-gastroesophageal-junction-with-liver-metastases
#8
Divaldo Monteiro de Melo Santos, Eudaldo López-Tomassetti Fernández, Miguel Sánchez Ramos, Juan Ramón Hernández Hernández
No abstract text is available yet for this article.
July 4, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28685087/heterogeneity-in-the-colorectal-primary-tumor-and-the-synchronous-resected-liver-metastases-prior-to-and-after-treatment-with-an-anti-egfr-monoclonal-antibody
#9
Daniela Adua, Francesca Di Fabio, Giorgio Ercolani, Michelangelo Fiorentino, Elisa Gruppioni, Annalisa Altimari, Fabiola Lorena Rojas Limpe, Nicola Normanno, Antonio Daniele Pinna, Carmine Pinto
Molecular heterogeneity between primary tumors (PTs) and synchronous resected liver metastasis in colorectal cancer (CRC) has potential relevance in treatment strategies. Next-generation sequencing (NGS) may be able to increase the chances of identifying multiple molecular driver alterations, calling for therapy. The aim of the present study was to evaluate mutations in PT and synchronous resected liver metastases for patients with Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) exon 2 wild-type metastatic (m)CRC who underwent chemotherapy (CT) featuring an anti-epidermal growth factor receptor (EGFR) monoclonal antibody...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28685083/complete-response-to-second-line-chemotherapy-with-sunitinib-of-a-gastrointestinal-stromal-tumor-a-case-report
#10
Tsuyoshi Shirakawa, Tomoya Hirata, Kosuke Maemura, Toshiyuki Goto, Yoshiya Shimao, Kosuke Marutsuka, Yuji Ueda, Ikuo Kikuchi
Gastrointestinal stromal tumors (GISTs) are a type of sarcoma, and the most common mesenchymal tumor of the gastrointestinal tract. Systemic chemotherapy is recommended for unresectable or metastatic GISTs. Imatinib is an oral multitargeted receptor tyrosine kinase inhibitor that is effective as adjuvant chemotherapy for primary high-risk cases, and as palliative chemotherapy for unresectable or metastatic cases. For imatinib-resistant cases, second-line chemotherapy with sunitinib is recommended due to significantly longer median progression-free survival and higher response rates compared with a placebo...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28682846/punctate-radiation-dermatitis-of-the-foot-and-ankle-caused-by-distal-embolization-of-90y-microspheres-during-liver-directed-therapy
#11
Benjamin B Nia, Emily S Nia, Ryan J Avery, Phillip H Kuo, Charles T Hennemeyer
A 41-year-old man with gastric adenocarcinoma presented with hepatic metastases. The metastases were refractory to systemic chemotherapy, so radioembolization with Y microspheres was performed. Because of stasis or saturation of the tumor with embolic particles, 79% of the microspheres were injected. At follow-up, the patient complained of "red bumps" that had developed on his right foot/ankle the day after the radioembolization. Because a portion of the dose was still in the catheter when withdrawn from the right femoral artery, the interventional radiologist used a Geiger counter to confirm radioactivity in the cutaneous lesions and thus the distal embolization of the microspheres...
July 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28681367/expandable-metallic-stent-for-endobronchial-metastasis-from-colorectal-cancer-reports-of-2-cases
#12
Tomoki Nakamura, Takayuki Tajima, Takashi Ogimi, Hiroshi Miyakita, Miho Nitta, Kazunori Myojin, Sakurako Tajiri, Ichiro Kobayashi, Takayuki Nishi, Sotaro Sadahiro, Hideo Shimada
In recent years, there have been many reports about the efficacy of stenting for central bronchial stenosis. When central bronchial stenosis is due to metastasis of a malignant tumor to the trachea and/or bronchi (endobronchial metastasis: EM), it is classified as "narrow EM" and "broad EM." [1] We managed two patients in whom bilateral stent placement was required for narrow and broad EM arising from colorectal cancer. Case 1: In September 2011, a 66-year-old man underwent low anterior resection for advanced colorectal cancer associated with unresectable liver metastasis...
July 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28679984/a-case-of-a-patient-with-granulocyte-colony-stimulating-factor-producing-pancreatic-cancer-who-responded-to-nab-paclitaxel-plus-gemcitabine
#13
Kunio Kataoka, Koichi Achiwa, Yoshiyuki Minami, Motokazu Fujita, Takehito Naitoh, Masahiro Yamada, Hideko Yamamoto, Hiroshi Matsubara, Fumihiro Urano
A 67-year-old male patient presented with an irregular mass involving the pancreatic body and tail with multiple liver/lymph node metastases. A biopsy indicated the presence of a poorly differentiated adenocarcinoma. Fever and increased white blood cell count, C-reactive protein levels, and granulocyte-colony stimulating factor (G-CSF) levels led to the diagnose of G-CSF-producing pancreatic cancer. The patient did not respond to FOLFIRINOX therapy (leucovorin, fluorouracil, irinotecan, and oxaliplatin), but nab-paclitaxel plus gemcitabine treatment was effective, resulting in tumor shrinkage and reduced G-CSF levels...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28675363/comparative-analysis-between-simultaneous-resection-and-staged-resection-for-synchronous-colorectal-liver-metastases-a-single-center-experience-on-300-consecutive-patients
#14
Sorin Alexandrescu, Andrei Diaconescu, Zenaida Ionel, Cristian Zlate, Răzvan Grigorie, Doina Hrehoreţ, Vladislav Braşoveanu, Simona Dima, Florin Botea, Mihnea Ionescu, Dana Tomescu, Gabriela Droc, Ruxandra Fota, Adina Croitoru, Iulia Gramaticu, Florina Buica, Razvan Iacob, Cristian Gheorghe, Vlad Herlea, Mugur Grasu, Radu Dumitru, Mirela Boroş, Irinel Popescu
Introduction: In synchronous colorectal liver metastases (SCLMs), simultaneous resection (SR) of the primary tumor and liver metastases has not gained wide acceptance. Most authors prefer staged resections (SgR), especially in patients presenting rectal cancer or requiring major hepatectomy. Methods: Morbidity, mortality, survival rates and length of hospital stay were compared between the two groups of patients (SR vs. SgR). A subgroup analysis was performed for patients with similar characteristics (e.g. rectal tumor, major hepatectomy, bilobar metastases, metastatic lymph nodes, preoperative chemotherapy)...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28668425/early-liver-metastases-in-resectable-periampullary-cancer-incidence-and-risk-factors
#15
A S Guerard, A Ayav, H Busby, M Lafitte, H Rousseau, V Laurent
PURPOSE: The aim of the present study was to estimate the incidence of very early hepatic metastases (HMs) (<6 months) and their imaging patterns after cephalic duodenopancreatectomy (CDP) for periampullary carcinoma (excluding duodenal carcinoma) and to identify their associated risk factors. METHODS: From January 2003 to June 2016, all patients who underwent surgical treatment for periampullary carcinoma by CDP at our institution and with adequate pre- and postoperative CT scans were included...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28665451/discordance-in-ras-mutations-between-primary-colon-tumor-and-metastases-a-real-event-or-a-matter-of-methodology
#16
Alfonso De Stefano, Mario Rosanova, Umberto Malapelle, Maurizio Martini, Stefano De Falco, Laura Attademo, Giovanni Fiore, Tonia Cenci, Claudio Bellevicine, Sabino De Placido, Giancarlo Troncone, Chiara Carlomagno
BACKGROUND: Analysis of K- and N-RAS mutations is mandatory before planning treatment of metastatic colorectal cancer, because only RAS wild-type (WT) patients can benefit from treatment with anti-EGFR monoclonal antibodies (cetuximab and panitumumab). CASE REPORT: Here we report the case of a 69-year-old male patient affected by metastatic sigmoid cancer. He underwent left hemicolectomy, and histology diagnosed a well-differentiated, pT4, node-positive adenocarcinoma; KRAS analysis performed with direct sequencing identified a mutation in exon 2 of the KRAS gene (GGT->GTT)...
June 20, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28655081/-prognostic-analysis-of-colorectal-liver-metastases-treated-by-surgery-combined-with-intraoperative-radiofrequency-ablation
#17
R Mao, J J Zhao, X Y Bi, H Zhao, Z Y Li, Z Huang, Y F Zhang, X Chen, H J Hu, X L Wu, X H Hu, J Q Cai
Objective: To investigate the clinical value of intraoperative radiofrequency ablation (RFA) in the treatment of colorectal liver metastasis (CLM). Methods: A retrospectively analysis of 187 patients with CLM who underwent liver resection with or without RFA from January 2009 to August 2016 in Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences was performed. According to whether RFA was used intraoperatively, patients were divided into resection only group and combined treatment group...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28655075/-surgical-treatment-of-colorectal-liver-metastases
#18
J M Xu, D X Zhu, L Ren
Surgical resection of the metastases offers the only opportunity for long-term survival in colorectal liver metastases. However, only 10% to 20% of patients present with resectable disease, and so how to increase surgical patients has been a clinical hotspot. In addition to expanding surgical indications, two-stage hepatectomy and convertible therapy are optional. In convertible therapy, initial treatment regimen decides long-term benefit, and it is important to select appropriate patient population in addition to Ras status when anti-epithelial growth factor receptor monoclonal antibody is used...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28652999/management-of-colorectal-cancer-with-synchronous-liver-metastases-impact-of-multidisciplinary-case-conference-review
#19
Kerollos N Wanis, Karen Pineda-Solis, Mauro E Tun-Abraham, Jake Yeoman, Stephen Welch, Kelly Vogt, Julie Ann M Van Koughnett, Michael Ott, Roberto Hernandez-Alejandro
BACKGROUND: While no evidence exists to support mandatory multidisciplinary case conference (MCC) review for patients with synchronous colorectal cancer and liver metastases, this unique population may benefit greatly from multidisciplinary discussion. METHODS: We retrospectively identified patients who underwent liver resection with curative intent for colorectal liver metastases (CRLM) at a tertiary center between January 2008 and June 2015. The characteristics of patients discussed at a weekly regional MCC were examined, and the effect of MCC review on treatment approach was assessed...
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28646261/hepatic-arterial-infusion-chemotherapy-for-extensive-liver-metastases-of-breast-cancer-efficacy-safety-and-prognostic-parameters
#20
Mitra Tewes, Michael Wilhelm Peis, Simon Bogner, Jens M Theysohn, Marcus Paul Reinboldt, Martin Schuler, Anja Welt
PURPOSE: Hepatic arterial infusion chemotherapy (HAIC) is an option for patients with liver-predominant metastatic breast cancer (LMBC), when no further systemic treatment is available. But systematic reports are limited. Here we conducted a retrospective analysis of LMBC patients treated at an expert center. METHODS: Individual patient data were retrieved from the clinical data base of the West German Cancer Center. Primary endpoints included hepatic response (RECIST), progression-free survival (PFS), overall survival (OS), and toxicity...
June 23, 2017: Journal of Cancer Research and Clinical Oncology
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