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Liver metastases chemotherapy

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https://www.readbyqxmd.com/read/28433600/hepatic-arterial-infusion-chemotherapy-for-unresectable-liver-metastases-of-colorectal-cancer-a-multicenter-retrospective-study
#1
REVIEW
Annie Lim, Samuel Le Sourd, Hélène Senellart, Dominique Luet, Frédéric Douane, Christophe Perret, Antoine Bouvier, Sylvie Métairie, Estelle Cauchin, Philippe Rougier, Tamara Matysiak-Budnik, Yann Touchefeu
Hepatic arterial infusion chemotherapy (HAIC) is a treatment used for liver metastases (LM) of colorectal cancer (CRC). Because of its technical conditions, it has been used in only a few experienced centers in France. Our aim was to evaluate its feasibility, efficacy and tolerance in 4 centers. Clinical, biological, and radiological data of patients treated with HAIC for unresectable LM from CRC in 4 institutions from October 2011 to January 2016 were retrospectively analyzed. Sixty-one patients with unresectable LM from CRC were included...
March 14, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28431480/predictive-and-prognostic-factors-associated-with-soft-tissue-sarcoma-response-to-chemotherapy-a-subgroup-analysis-of-the-european-organisation-for-research-and-treatment-of-cancer-62012-study
#2
Robin J Young, Saskia Litière, Michela Lia, Pancras C W Hogendoorn, Cyril Fisher, Gunhild Mechtersheimer, Søren Daugaard, Raf Sciot, Françoise Collin, Christina Messiou, Viktor Grünwald, Alessandro Gronchi, Winette van der Graaf, Eva Wardelmann, Ian Judson
BACKGROUND: The European Organization for Research and Treatment of Cancer (EORTC) 62012 study was a Phase III trial of doxorubicin versus doxorubicin-ifosfamide chemotherapy in 455 patients with advanced soft tissue sarcoma (STS). Analysis of the main study showed that combination chemotherapy improved tumor response and progression-free survival, but differences in overall survival (OS) were not statistically significant. We analyzed factors prognostic for tumor response and OS, and assessed histological subgroup and tumor grade as predictive factors to identify patients more likely to benefit from combination chemotherapy...
April 21, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28426374/perioperative-hepatic-arterial-infusion-pump-chemotherapy-is-associated-with-longer-survival-after-resection-of-colorectal-liver-metastases-a-propensity-score-analysis
#3
Bas Groot Koerkamp, Eran Sadot, Nancy E Kemeny, Mithat Gönen, Julie N Leal, Peter J Allen, Andrea Cercek, Ronald P DeMatteo, T Peter Kingham, William R Jarnagin, Michael I D'Angelica
Purpose To investigate whether perioperative hepatic arterial infusion pump chemotherapy (HAI) was associated with overall survival (OS) in patients who had a complete resection of colorectal liver metastases (CLM). Methods Patients who underwent a complete resection of CLM between 1992 and 2012 were included from a single-center prospectively maintained database. All patients who received HAI also received perioperative systemic chemotherapy. Propensity score analysis was used to match patients for seven known prognostic factors...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28422039/-urinary-tract-lymphoepithelial-carcinoma-report-of-two-cases-and-bibliographic-review
#4
Sebastian Valverde Martínez, Waleska Salcedo Mercado, Isabel Rodríguez Cruz, Sara Belén Prieto Nogal, Mario Martín Hernández, Luis Miguel Gómez Tejeda
OBJECTIVE: We report two cases of patients diagnosed with lymphoepithelioma-like carcinomas of the urinary tract. We review the literature of this rare entity. The objective is to clarify the clinical and therapeutic characteristics. METHODS: We present a retrospective review of medical records of two patients diagnosed with lymphoepithelioma-like carcinomas, one in the renal pelvis and the other in the bladder. We review the epidemiology, diagnosis and therapeutic alternatives...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28420444/case-report-acth-secreting-pituitary-carcinoma-metastatic-to-the-liver-in-a-patient-with-a-history-of-atypical-pituitary-adenoma-and-cushing-s-disease
#5
Amy S Joehlin-Price, Douglas A Hardesty, Christina A Arnold, Lawrence S Kirschner, Daniel M Prevedello, Norman L Lehman
BACKGROUND: Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in relation to the existing literature. CASE PRESENTATION: The patient is a 51-year-old woman with Cushing's disease and intact adrenal glands who was diagnosed with metastatic pituitary carcinoma to the liver, 29 months after initial resection of an ACTH-secreting primary atypical pituitary adenoma (APA)...
April 18, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28419692/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-after-pre-operative-chemotherapy
#6
Florian W R Vondran, Felix Oldhafer, Kristina I Ringe, Thomas C Wirth, Moritz Kleine, Mark D Jäger, Juergen Klempnauer, Hueseyin Bektas
BACKGROUND: Recently a procedure termed 'Associating Liver Partition and Portal vein ligation for Staged hepatectomy' (ALPPS) was developed to increase the resectability of marginally resectable or locally unresectable liver tumours. This study focused on the application of ALPPS in patients with advanced colorectal liver metastases (CRLM) and pre-operative chemotherapy, with the aim to investigate whether the latter still allows for sufficient hypertrophy of the future liver remnant (FLR) following the first step of ALPPS...
April 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28416060/-gas-filled-liver-metastases-caused-by-clostridium-septicum-sepsis
#7
Kristina Buchardi Nielsen, Hanne Krogh Rose
In this case report a 73-year-old male with liver-metastatic colon cancer was admitted to hospital due to severe abdominal pain merely four days after receiving chemotherapy including epidermal growth factor receptor inhibitors. An acute computed tomography revealed gas-filled liver metastases with two possible diagnoses of either a rapid tumour response resulting in tumour necrosis or severe bacterial infection involving liver metastases. Moreover, the patient had an anaerobic infection with Clostridium septicum, and despite relevant treatment he died within 12 hours after admission...
April 17, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28415940/thymoma-metastatic-to-liver-and-pancreas-case-report-and-review-of-the-literature
#8
Nicola Passuello, Gioia Pozza, Stella Blandamura, Michele Valmasoni, Cosimo Sperti
A 71-year-old man presented with a thymic mass involving the superior vena cava. A mediastinoscopical biopsy initially suggested a diagnosis of type A thymoma. After neoadjuvant chemotherapy, the patient underwent en-bloc thymectomy and vascular resection for a pathology-confirmed type B3 thymoma involving the superior vena cava, the left brachiocephalic vein and the distal part of the right brachiocephalic vein. Adjuvant radiotherapy was administered. Two years after the primary surgery, abdominal computed tomography (CT) and whole body fluorodeoxyglucose (18-FDG) positron emission tomography (PET) scans showed a single hepatic lesion that was treated with wedge liver resection...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28413658/subcutaneous-metastasis-arising-from-gastric-cancer-a-case-report
#9
Tsutomu Namikawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Tomoaki Yatabe, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
A 59-year-old man was referred to the Kochi Medical School Hospital due to left shoulder pain. Physical examination revealed a nodular, painful mass lesion in the subcutaneous tissue of the right chest wall, with a diameter of ~2 cm. Esophagogastroduodenoscopy revealed a large ulcerated tumor in the lower gastric body near the lesser curvature, and biopsy specimens of the gastric and humeral lesions revealed poorly differentiated adenocarcinoma. Abdominal computed tomography revealed multiple low-density lesions in the liver and a well-defined, 2...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28412028/-effectiveness-of-erlotinib-in-critical-care-unit-in-patients-with-non-small-cell-lung-cancer-with-egfr-mutation
#10
M Dewolf, C Dayen, C Garoute, W Khamis, M Fourrier, F Rousselle, M Sadki, F Le Meunier, R Suguenot, E Lecuyer, H Bentayeb, Y Douadi, P Berna
INTRODUCTION: The search for mutations epidermal growth factor receptor (EGFR) has changed the therapeutic approach and prognosis of non-small cell lung cancer (NSCLC). The effectiveness of tyrosine kinase inhibitors (TKI) has been demonstrated orally in patients with EGFR mutation. We report the case of a patient for whom treatment with TKI was started effectively in a Critical Care Unit. OBSERVATION: A patient of 59 years is followed for a stage IV lung adenocarcinoma with metastases in liver, brain, adrenal, lung and pleura...
April 12, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28409832/influence-of-neoadjuvant-chemotherapy-on-resection-of-primary-colorectal-liver-metastases-a-propensity-score-analysis
#11
Moritz J Strowitzki, Thomas Schmidt, Ulrich Keppler, Alina S Ritter, Sarah Mahmoud, Johannes Klose, André L Mihaljevic, Martin Schneider, Markus W Büchler, Alexis B Ulrich
BACKGROUND AND OBJECTIVES: There is ongoing debate about whether patients planned for liver resection of colorectal liver metastases (CRLM) benefit from neoadjuvant chemotherapy (NC). Therefore, we performed a retrospective survival analysis of patients with and without NC prior to surgery. METHODS: Data prospectively collected from 468 consecutive patients were analyzed in a retrospective design. We performed a survival analysis and added propensity score matching (PSM)...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407529/resection-of-colorectal-liver-metastases-after-second-line-chemotherapy-is-it-worthwhile-a-livermetsurvey-analysis-of-6415-patients
#12
René Adam, Bin Yi, Pasquale F Innominato, Eduardo Barroso, Christophe Laurent, Felice Giuliante, Lorenzo Capussotti, Réal Lapointe, Jean-Marc Regimbeau, Santiago Lopez-Ben, Helena Isoniemi, Catherine Hubert, Jen-Kou Lin, Thomas Gruenberger, Dominique Elias, Oleg G Skipenko, Alfredo Guglielmi
PURPOSE: Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line. PATIENTS AND METHODS: From January 2005 to June 2013, 5624 and 791 consecutive patients of a prospective international cohort received 1 and 2 PCT lines before CLM resection (group 1 and 2, respectively)...
April 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28405961/treatment-patterns-and-early-outcomes-of-alk-positive-non-small-cell-lung-cancer-patients-receiving-ceritinib-a-chart-review-study
#13
Edmond Bendaly, Anand A Dalal, Kenneth Culver, Philip Galebach, Iryna Bocharova, Rebekah Foster, Medha Sasane, Alexander R Macalalad, Annie Guérin
INTRODUCTION: This study aimed to provide the first real-world description of the characteristics, treatments, dosing patterns, and early outcomes of patients with ALK-positive non-small cell lung cancer (NSCLC) who received ceritinib in US clinical practice. METHODS: US oncologists provided data from medical charts of adult patients diagnosed with locally advanced or metastatic ALK-positive NSCLC who received ceritinib following crizotinib. Patient characteristics, treatment patterns, ceritinib dosing, early outcomes, and occurrence of gastrointestinal adverse events (AEs) by dose and instructions on food intake were assessed, and Kaplan-Meier analysis was used to describe clinician-defined progression-free survival (PFS) on ceritinib...
April 12, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28391025/establishment-and-validation-of-m1-stage-subdivisions-for-de-novo-metastatic-nasopharyngeal-carcinoma-to-better-predict-prognosis-and-guide-treatment
#14
Xiong Zou, Rui You, Huai Liu, Yu-Xiang He, Guo-Feng Xie, Zhi-Hai Xie, Ji-Bin Li, Rou Jiang, Li-Zhi Liu, Li Li, Meng-Xia Zhang, You-Ping Liu, Yi-Jun Hua, Ling Guo, Chao-Nan Qian, Hai-Qiang Mai, Dong-Ping Chen, Ying Luo, Liang-Fang Shen, Ming-Huang Hong, Ming-Yuan Chen
BACKGROUND: To better manage patients with de novo metastatic NPC (mNPC) including easily identifying individuals' survival outcomes and accurately choosing the most suitable treatment. MATERIALS AND METHODS: Three independent cohorts of mNPC patients (a training set of n = 462, an internal prospective validation set of n = 272 and an external prospective validation set of n = 243) were studied. The radiological characteristics of distant metastases, including number of metastatic locations, number of metastatic lesions and size of metastatic lesions, were carefully defined based on imaging data...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28389316/maintenance-therapy-with-vinflunine-plus-best-supportive-care-versus-best-supportive-care-alone-in-patients-with-advanced-urothelial-carcinoma-with-a-response-after-first-line-chemotherapy-maja-sogug-2011-02-a-multicentre-randomised-controlled-open-label-phase
#15
Jesus García-Donas, Albert Font, Begoña Pérez-Valderrama, José Antonio Virizuela, Miquel Ángel Climent, Susana Hernando-Polo, José Ángel Arranz, Maria Del Mar Llorente, Nuria Lainez, José Carlos Villa-Guzmán, Begoña Mellado, Aránzazu González Del Alba, Daniel Castellano, Enrique Gallardo, Urbano Anido, Xavier García Del Muro, Montserrat Domènech, Javier Puente, Rafael Morales-Barrera, Jose Luis Pérez-Gracia, Joaquim Bellmunt
BACKGROUND: Maintenance therapy improves outcomes in various tumour types, but cumulative toxic effects limit the choice of drugs. We investigated whether maintenance therapy with vinflunine would delay disease progression in patients with advanced urothelial carcinoma who had achieved disease control with first-line chemotherapy. METHODS: We did a randomised, controlled, open-label, phase 2 trial in 21 Spanish hospitals. Eligible patients had locally advanced, surgically unresectable, or metastatic transitional-cell carcinoma of the urothelial tract, adequate organ function, and disease control after four to six cycles of cisplatin and gemcitabine (carboplatin allowed after cycle four)...
April 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28386283/rare-gingival-metastasis-by-hepatocellular-carcinoma
#16
Li-Jun Xue, Xiao-Bei Mao, Jian Geng, Ya-Nan Chen, Qian Wang, Xiao-Yuan Chu
Hepatocellular carcinoma (HCC) uncommonly metastasizes to the gingiva, which always means a poor outcome. We reported a rare HCC case with multiple metastases to gingiva, lungs, and brain. A 60-year-old man was initially diagnosed as HCC with metastases to double lungs. He was subjected to a transarterial chemoembolization (TACE) (5-fluorouracil, 750 mg) and two cycles of intravenous chemotherapy (gemcitabine 1.8 g at days 1 and 8, oxaliplatin 200 mg at day 2, every 4 weeks). However, the volume of liver tumor still increased...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28383673/overall-survival-prediction-and-usefulness-of-second-line-chemotherapy-in-advanced-pancreatic-adenocarcinoma
#17
Angélique Vienot, Guillaume Beinse, Christophe Louvet, Louis de Mestier, Aurélia Meurisse, Francine Fein, Bruno Heyd, Denis Cleau, Christelle d'Engremont, Anne-Claire Dupont-Gossart, Zaher Lakkis, Christophe Tournigand, Olivier Bouché, Benoît Rousseau, Cindy Neuzillet, Franck Bonnetain, Christophe Borg, Dewi Vernerey
Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning of L2 and to assess the benefit from chemotherapy among the identified risk groups. Methods: Analyses were derived from all consecutive aPDAC patients treated at Besancon University Hospital, Besancon, France, between January 2003 and December 2013 (n = 462)...
April 4, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28382143/albumin-to-alkaline-phosphatase-ratio-a-novel-prognostic-index-of-overall-survival-in-cisplatin-based-chemotherapy-treated-patients-with-metastatic-nasopharyngeal-carcinoma
#18
Man Nie, Peng Sun, Cui Chen, Xiwen Bi, Yu Wang, Hang Yang, Panpan Liu, Zhiming Li, Yi Xia, Wenqi Jiang
The Albumin-to-Alkaline Phosphatase Ratio (AAPR) has been recently revealed as a prognostic index for hepatocellular carcinoma, whereas its role in metastatic nasopharyngeal cancer (NPC) remains unclear. The aim of this study was to evaluate the clinical value of AAPR in patients with metastatic NPC. We retrospectively reviewed 209 metastatic NPC patients treated with cisplatin-based regimens. Survival data were calculated using the Kaplan-Meier method and were compared using the log-rank test. Univariate and multivariate survival analyses were conducted using the Cox proportional hazards regression methodology...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28379870/apc-and-pik3ca-mutational-cooperativity-predicts-pathologic-response-and-survival-in-patients-undergoing-resection-for-colorectal-liver-metastases
#19
Suguru Yamashita, Yun-Shin Chun, Scott E Kopetz, Dipen Maru, Claudius Conrad, Thomas A Aloia, Jean-Nicolas Vauthey
OBJECTIVE: The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). BACKGROUND: Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies. METHODS: We identified 396 patients with primary colorectal cancer and known somatic mutation status by next-generation sequencing who underwent hepatectomy for CLM (2005-2015)...
April 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28373428/effect-of-whole-abdominal-irradiation-on-penetration-depth-of-doxorubicin-in-normal-tissue-after-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-a-post-mortem-swine-model
#20
Veria Khosrawipour, Tanja Khosrawipour, Yousef Hedayat-Pour, David Diaz-Carballo, Alexander Bellendorf, Hugo Böse-Ribeiro, Ralph Mücke, Nirushika Mohanaraja, Irenäus Anton Adamietz, Khashayar Fakhrian
BACKGROUND: This study was performed to evaluate the impact of whole-abdominal irradiation on local penetration of doxorubicin into the peritoneum and the abdominal organs in a post-mortem swine model. MATERIALS AND METHODS: Doxorubicin was aerosolized into the abdominal cavity of swine at a pressure of 12 mmHg CO2 at room temperature (25°). One swine was subjected to pressurized intraperitoneal aerosol chemotherapy (PIPAC) using Micropump(©) without irradiation; the second one received 2 Gy and the third one 7 Gy whole-abdominal irradiation, 15 min prior to PIPAC application...
April 2017: Anticancer Research
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