Emanuele Pizzo, Daniel O Cervantes, Harshada Ketkar, Valentina Ripa, Drew M Nassal, Benjamin Buck, Sreema P Parambath, Valeria Di Stefano, Kanwardeep Singh, Carl I Thompson, Peter J Mohler, Thomas J Hund, Jason T Jacobson, Sudhir Jain, Marcello Rota
Diastolic dysfunction and delayed ventricular repolarization are typically observed in the elderly, but whether these defects are intimately associated in the progressive manifestation of the aging myopathy remains to be determined. In this regard, aging in experimental animals is coupled with increased late Na+ current (INaL ) in cardiomyocytes, raising the possibility that INaL conditions the modality of electrical recovery and myocardial relaxation of the aged heart. For this purpose, aging male and female wild-type (WT) C57Bl/6 mice were studied together with genetically engineered mice with phosphomimetic (gain-of-function, GoF) or ablated (loss-of-function, LoF) mutations of the sodium channel Nav1...
April 19, 2024: American Journal of Physiology. Heart and Circulatory Physiology