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https://www.readbyqxmd.com/read/28108054/acute-respiratory-compromise-in-the-emergency-department-a-description-and-analysis-of-3571-events-from-the-get-with-the-guidelines-resuscitation%C3%A2-registry
#1
Carl Mathias Karlsson, Michael W Donnino, Hans Kirkegaard, Michael N Cocchi, Maureen Chase, Lars W Andersen
BACKGROUND: Respiratory events requiring the use of assisted ventilation are relatively common in the emergency department (ED), and can be associated with substantial morbidity and mortality. OBJECTIVE: The aim of this study was to describe and elucidate patient and event characteristics associated with mortality and progression to cardiac arrest in ED patients with acute respiratory compromise. METHODS: Data were obtained from the multicenter Get With the Guidelines-Resuscitation® registry...
January 17, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28105111/effect-of-rocuronium-on-the-bispectral-index-under-anesthesia-and-tracheal-intubation
#2
Hui Yue, Jinyu Han, Ling Liu, Kaiyuan Wang, Jincheng Li
The aim of the present study was to investigate the effect of various doses of rocuronium on bispectral index (BIS) responses to propofol induction and tracheal intubation, as well as the role of the non-depolarization muscle relaxant rocuronium on the depth of sedation. A total of 72 patients (American Society of Anesthesiologists physical status I-II) were anaesthetized with propofol using a target-controlled infusion, and randomly divided into two sedation level groups (n=36). The patients were divided into 2 groups according to the BIS value: A normal sedation group (group 1), with a stable BIS value at 40-60, and a deep sedation group (group 2), with a BIS value <20 or with burst suppression...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28103532/timing-of-anticoagulant-re-initiation-following-intracerebral-hemorrhage-in-mechanical-heart-valves-survey-of-neurosurgeons-and-thrombosis-experts
#3
Fahad AlKherayf, Yan Xu, Harrison Westwick, Ioana Doina Moldovan, Philip S Wells
BACKGROUND: While oral anticoagulation (OAC) is universally indicated for patients with mechanical heart valves (MHVs), OAC resumption following anticoagulant-associated intracerebral hemorrhage (ICH) is an area of uncertainty. We sought to determine the practice preferences of North American neurosurgeons and thrombosis experts on optimal timing of OAC re-initiation. METHODS: A cross-sectional survey was disseminated to North American members of the American Association of Neurological Surgeons and the International Society for Thrombosis and Haemostasis...
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28102864/transthyretin-v122i-pv142i-cardiac-amyloidosis-an-age-dependent-autosomal-dominant-cardiomyopathy-too-common-to-be-overlooked-as-a-cause-of-significant-heart-disease-in-elderly-african-americans
#4
REVIEW
Joel N Buxbaum, Frederick L Ruberg
Since the identification of a valine-to-isoleucine substitution at position 122 (TTR V122I; pV142I) in the transthyretin (TTR)-derived fibrils extracted from the heart of a patient with late-onset cardiac amyloidosis, it has become clear that the amyloidogenic mutation and the disease occur almost exclusively in individuals of identifiable African descent. In the United States, the amyloidogenic allele frequency is 0.0173 and is carried by 3.5% of community-dwelling African Americans. Genotyping across Africa indicates that the origin of the allele is in the West African countries that were the major source of the slave trade to North America...
January 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28098065/the-treatment-of-post-thrombotic-syndrome
#5
Karina Schleimer, Mohammad Esmaeil Barbati, Alexander Gombert, Volker Wienert, Jochen Grommes, Houman Jalaie
BACKGROUND: Post-thrombotic syndrome (PTS) arises in 20-50% of patients who have sustained a deep vein thrombosis and markedly impairs their quality of life. METHODS: This review is based on pertinent publications retrieved by a selective literature search in PubMed and the Cochrane Library, and on the guidelines of the German Societies of Phlebology and Vascular Surgery (Deutsche Gesellschaft für Phlebologie, Deutsche Gesellschaft für Gefässchirurgie). RESULTS: The treatment options are conservative treatment with compression and patient exercises, endovascular recanalization with stent angioplasty, and open bypass surgery of the iliac obstructions...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28096704/neonatal-resuscitation-advances-in-training-and-practice
#6
REVIEW
Taylor Sawyer, Rachel A Umoren, Megan M Gray
Each year in the US, some four hundred thousand newborns need help breathing when they are born. Due to the frequent need for resuscitation at birth, it is vital to have evidence-based care guidelines and to provide effective neonatal resuscitation training. Every five years, the International Liaison Committee on Resuscitation (ILCOR) reviews the science of neonatal resuscitation. In the US, the American Heart Association (AHA) develops treatment guidelines based on the ILCOR science review, and the Neonatal Resuscitation Program (NRP) translates the AHA guidelines into an educational curriculum...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28096207/use-of-strategies-to-improve-door-to-needle-times-with-tissue-type-plasminogen-activator-in-acute-ischemic-stroke-in-clinical-practice-findings-from-target-stroke
#7
Ying Xian, Haolin Xu, Barbara Lytle, Jason Blevins, Eric D Peterson, Adrian F Hernandez, Eric E Smith, Jeffrey L Saver, Steven R Messé, Mary Paulsen, Robert E Suter, Mathew J Reeves, Edward C Jauch, Lee H Schwamm, Gregg C Fonarow
BACKGROUND: The implementation of Target: Stroke Phase I, the first stage of the American Heart Association's national quality improvement initiative to accelerate door-to-needle (DTN) times, was associated with an average 15-minute reduction in DTN times. TARGET: Stroke phase II was launched in April 2014 with a goal of promoting further reduction in treatment times for tissue-type plasminogen activator (tPA) administration. METHODS AND RESULTS: We conducted a second survey of Get With The Guidelines-Stroke hospitals regarding strategies used to reduce delays after Target: Stroke and quantify their association with DTN times...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28092931/the-criteria-of-metabolic-syndrome-and-national-health-checkup-and-education-system-in-japan
#8
Kazumasa Yamagishi, Hiroyasu Iso
Two major definitions of metabolic syndrome have been proposed. One focuses on accumulation of risk factors such as the American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) criteria; and the other focuses on abdominal obesity such as the International Diabetes Federation (IDF) and Japanese criteria. The latter consider waist circumference as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA and the other organizations attempted to unify these criteria, and waist circumference is no longer an obligatory component...
January 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28090166/society-for-immunotherapy-of-cancer-and-american-heart-association
#9
Walter Alexander
We review key sessions from the Society for Immunotherapy of Cancer and the American Heart Association annual meetings.
January 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28089498/anticoagulants-in-ischemia-guided-management-of-non-st-elevation-acute-coronary-syndromes
#10
REVIEW
Martin Mayer
BACKGROUND: The most recent joint guidelines from the American Heart Association (AHA) and American College of Cardiology (ACC) on the management of non-ST-elevation acute coronary syndromes (NSTE-ACS) are a result of a substantial and considered undertaking, and those involved deserve much recognition for their efforts. However, the handling of anticoagulants seems somewhat inadequate, and this is a highly-relevant matter when managing NSTE-ACS. OBJECTIVE OF THE REVIEW: Among areas of potential uncertainty, emergency medicine professionals might still be left wondering about the particulars of anticoagulant therapy when pursuing ischemia-guided management of NSTE-ACS (that is, managing NSTE-ACS without an intent for early invasive measures, such as coronary angiography and revascularization)...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28089252/practical-approaches-for-whole-genome-sequence-analysis-of-heart-and-blood-related-traits
#11
Alanna C Morrison, Zhuoyi Huang, Bing Yu, Ginger Metcalf, Xiaoming Liu, Christie Ballantyne, Josef Coresh, Fuli Yu, Donna Muzny, Elena Feofanova, Navin Rustagi, Richard Gibbs, Eric Boerwinkle
Whole-genome sequencing (WGS) allows for a comprehensive view of the sequence of the human genome. We present and apply integrated methodologic steps for interrogating WGS data to characterize the genetic architecture of 10 heart- and blood-related traits in a sample of 1,860 African Americans. In order to evaluate the contribution of regulatory and non-protein coding regions of the genome, we conducted aggregate tests of rare variation across the entire genomic landscape using a sliding window, complemented by an annotation-based assessment of the genome using predefined regulatory elements and within the first intron of all genes...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28089232/prevalence-of-ischemic-heart-disease-and-associated-factors-in-patients-with-rheumatoid-arthritis-in-southern-brazil
#12
Rafael Kmiliauskis Santos Gomes, Ana Carolina Albers, Ana Isadora Pianowski Salussoglia, Ana Maria Bazzan, Luana Cristina Schreiner, Mateus Oliveira Vieira, Patrícia Giovana da Silva, Patrícia Helena Machado, Cynthia Mara da Silva, Mauro Marcelo Mattos, Moacyr Roberto Cuce Nobre
OBJECTIVE: To estimate the prevalence of ischemic heart disease and associated factors in patients with rheumatoid arthritis. METHODS: A cross-sectional study using the American College of Rheumatology diagnostic criteria in order to select patients seen at primary or secondary health care units in Blumenau, Santa Catarina, Southern Brazil, in 2014. The presence of ischemic heart disease was defined as an acute myocardial infarction with percutaneous coronary intervention or coronary artery bypass graft surgery that has occurred after diagnosis...
December 21, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28087467/positive-childhood-experiences-and-ideal-cardiovascular-health-in-midlife-associations-and-mediators
#13
Natalie Slopen, Ying Chen, Jennifer L Guida, Michelle A Albert, David R Williams
In 2010, the American Heart Association introduced a new conceptual framework to encourage a focus on primary prevention and provided a definition for "ideal cardiovascular health". In this study we examined the relationship between positive childhood experience and ideal cardiovascular health in mid-life, and the extent to which education, depression, and social support mediate this association. Data are from participants in the Midlife and Aging in the United States study who completed a clinic-based assessment of health (N=1255, aged 34-84years, 2004-2005)...
January 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28079773/pregnancies-after-the-diagnosis-of-mild-gestational-diabetes-mellitus-and-risk-of-cardiometabolic-disorders
#14
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079556/cardiac-arrest-obstetric-cpr-acls
#15
Benjamin Cobb, Steven Lipman
In contrast with other high-resource countries, maternal mortality has seen an increase in the United States. Caring for pregnant women in cardiac arrest may prove uniquely challenging given the rarity of the event coupled by the physiological changes of pregnancy. Optimization of resuscitative efforts warrants special attention as described in the 2015 American Heart Association's "Scientific Statement on Maternal Cardiac Arrest." Current recommendations address a variety of topics ranging from the basic components of chest compressions and airway management to some of the logistical complexities and operational challenges involved in maternal cardiac arrest...
January 10, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28074747/liraglutide-a-glucagon-like-peptide-1-agonist-for-chronic-weight-management
#16
Kendra R Manigault, Maria Miller Thurston
OBJECTIVE: To review the efficacy and safety of liraglutide 3.0 mg for weight loss. DATA SOURCE: A literature search was performed using PubMed and MEDLINE from 2000 to 2016. The following key terms were used alone or in combination: glucagon-like peptide-1 agonist, liraglutide, obesity, overweight, and weight loss. Additional supporting literature was identified utilizing the reference lists of the preceding articles. STUDY SELECTION: Analyzed studies were published in English and investigated use of liraglutide and its impact on weight loss...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28074545/development-and-testing-of-a-database-of-nih-research-funding-of-aapm-members-a-report-from-aapm-working-group-for-the-development-of-a-research-database-wgdrd
#17
Brendan Whelan, Eduardo Moros, Rebecca Fahrig, James Deye, Thomas Yi, Michael Woodward, Paul Keall, Jeff Siewerdsen
PURPOSE: To produce and maintain a database of National Institutes of Health (NIH) funding of American Association of Physicists in Medicine (AAPM) members, to perform a top level analysis of this data, and to make this data (hereafter referred to as the AAPM research database) available for the use of the AAPM and its members. METHODS: NIH funded research dating back to 1985 is available for public download through the NIH exporter website, and AAPM membership information dating back to 2002 was supplied by the AAPM...
January 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28069248/race-is-associated-with-differences-in-airway-inflammation-in-patients-with-asthma
#18
Sharmilee M Nyenhuis, Jerry A Krishnan, Alalia Berry, William J Calhoun, Vernon M Chinchilli, Linda Engle, Nicole Grossman, Fernando Holguin, Elliot Israel, Rick A Kittles, Monica Kraft, Stephen C Lazarus, Erik B Lehman, David T Mauger, James N Moy, Stephen P Peters, Wanda Phipatanakul, Lewis J Smith, Kaharu Sumino, Stanley J Szefler, Michael E Wechsler, Sally Wenzel, Steven R White, Steven J Ackerman
BACKGROUND: African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear. OBJECTIVE: We sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively). METHODS: We performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet...
December 31, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28063813/assessment-of-vascular-function-in-low-socioeconomic-status-preschool-children-a-pilot-study
#19
Lama Ghazi, Tanja Dudenbostel, Daisy Xing, Deborah Ejem, Anne Turner-Henson, Cynthia Irwin Joiner, Olivia Affuso, Andres Azuero, Suzanne Oparil, David A Calhoun, Marti Rice, Fadi G Hage
Elevated brachial blood pressure (BP) in childhood tracks into adulthood. Central BP and measures of arterial stiffness, such as aortic augmentation index (AIx) and pulse wave velocity (PWV), have been associated with future cardiovascular disease. This pilot study assessed the feasibility of noninvasively measuring these parameters in preschool children and explored factors that may be associated with elevated BP in this age group. Brachial BP was measured using an electronic oscillometric unit (Dinamap PRO 100) and defined as elevated when systolic BP (SBP) and/or diastolic BP (DBP) was ≥ the 90th percentile for age, gender, and height...
December 24, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28063670/alarming-trends-in-ideal-cardiovascular-health-among-children-and-adolescents-in-beijing-china-2004-to-2014
#20
Hongbo Dong, Yinkun Yan, Junting Liu, Xiaoyuan Zhao, Hong Cheng, Dongqing Hou, Guimin Huang, Shengxu Li, Youfa Wang, Jie Mi
BACKGROUND: The American Heart Association's 2020 Strategic Goals have defined a new concept of cardiovascular health for adults and children, emphasizing the importance of primordial prevention of cardiovascular diseases. However, detailed data on the trends of ideal cardiovascular health in Chinese children and adolescents are sparse. METHODS: A total of 5596 children and adolescents (aged 6-18years) were selected from two cross-sectional surveys conducted in 2004 and 2014, respectively...
December 21, 2016: International Journal of Cardiology
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