keyword
https://read.qxmd.com/read/38247525/c2cd4b-evokes-oxidative-stress-and-vascular-dysfunction-via-a-pi3k-akt-pkc%C3%AE-signaling-pathway
#21
JOURNAL ARTICLE
Paola Di Pietro, Angela Carmelita Abate, Valeria Prete, Antonio Damato, Eleonora Venturini, Maria Rosaria Rusciano, Carmine Izzo, Valeria Visco, Michele Ciccarelli, Carmine Vecchione, Albino Carrizzo
High glucose-induced endothelial dysfunction is an important pathological feature of diabetic vasculopathy. While genome-wide studies have identified an association between type 2 diabetes mellitus (T2DM) and increased expression of a C2 calcium-dependent domain containing 4B (C2CD4B), no study has yet explored the possible direct effect of C2CD4B on vascular function. Vascular reactivity studies were conducted using a pressure myograph, and nitric oxide and oxidative stress were assessed through difluorofluorescein diacetate and dihydroethidium, respectively...
January 14, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38230790/chrysophanol-induces-apoptosis-and-ferroptosis-of-gastric-cancer-cells-by-targeted-regulation-of-mtor
#22
JOURNAL ARTICLE
Sujuan Xi, Wei Ding, Danping Weng, Yue Zeng, Kewei Gao, Qiuye Wu, Guoping Huang, Yufang Li, Haiyan Yue
Programmed cell death (PCD) induction is a promising strategy for killing gastric cancer cells. In this study, we investigated the effects of chrysophanol on apoptosis and ferroptosis in gastric cancer cells. Chrysophanol in concentrations ranging from 0 to 100 μM were used to treat GES-1, HGC-27 and AGS cells. Cell counting kit-8 assay, colony formation assay, 5-ethynyl-2'-deoxyuridine staining, flow cytometry, JC-1 probe insertion, dihydroethidium staining and western blotting were performed...
January 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38191050/3-sialyllactose-protects-against-lps-induced-endothelial-dysfunction-by-inhibiting-superoxide-mediated-erk1-2-stat1-activation-and-hmgb1-rage-axis
#23
JOURNAL ARTICLE
Dung Van Nguyen, Yujin Jin, Thuy Le Lam Nguyen, Lila Kim, Kyung-Sun Heo
AIM: Endothelial hyperpermeability is an early stage of endothelial dysfunction associated with the progression and development of atherosclerosis. 3'-Sialyllactose (3'-SL) is the most abundant compound in human milk oligosaccharides, and it has the potential to regulate endothelial dysfunction. This study investigated the beneficial effects of 3'-SL on lipopolysaccharide (LPS)-induced endothelial dysfunction in vitro and in vivo. MAIN METHODS: We established LPS-induced endothelial dysfunction models in both cultured bovine aortic endothelial cells (BAECs) and mouse models to determine the effects of 3'-SL...
February 1, 2024: Life Sciences
https://read.qxmd.com/read/38173197/gossypol-acetic-acid-alleviates-the-ferroptosis-of-chondrocytes-in-osteoarthritis-by-inhibiting-gpx4-methylation
#24
JOURNAL ARTICLE
JingJing Shang, Chenwei Xiong, Wei Jiang, Zhentang Yu, Junjie Zhang, Yi Zhang, Long Han, Kaisong Miao, Changlin Yu, Yong Huang, Xindie Zhou
BACKGROUND: Osteoarthritis (OA) is a chronic joint disease, usually accompanied by degeneration of the articular cartilage, fibrosis, bone hyperplasia around the joint, and damage to the entire articular surface. Gossypol is a natural phenolic compound isolated from the seed of cotton plants, and gossypol acetic acid (GAA) is a medicinal form of Gossypol. Recently, various biological activities of GAA, including anti-inflammatory and anti-tumor effects, have been widely reported. However, its effect on chondrocytes in OA has yet to be determined...
January 3, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38172265/sophocarpine-alleviates-doxorubicin-induced-heart-injury-by-suppressing-oxidative-stress-and-apoptosis
#25
JOURNAL ARTICLE
Hong-Jin Zhang, Yang Fu, Huang Zhang, Ze-Qun Lai, Yi-Fei Dong
Doxorubicin (DOX) is an effective anti-tumor drug accompanied with many side effects, especially heart injury. To explore what effects of sophocarpine (SOP) on DOX-induced heart injury, this study conducted in vivo experiment and in vitro experiment, and the C57BL/6J mice and the H9C2 cells were used. The experimental methods used included echocardiography, enzyme-linked immunosorbent assay (ELISA), dihydroethidium (DHE) staining, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, western blotting and so on...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38142642/gypenoside-xlix-attenuates-sepsis-induced-splenic-injury-through-inhibiting-inflammation-and-oxidative-stress
#26
JOURNAL ARTICLE
Baoshi Xu, Rongrong Yang, Jingchao Qiang, Xuhui Xu, Mengyuan Zhou, Xiaomeng Ji, Yingzhi Lu, Zibo Dong
BACKGROUND: To investigate the effect of Gypenoside XLIX (Gyp-XLIX) on acute splenic injury (ASI) induced by cecal ligation and puncture (CLP) in septic mice, a study was conducted. METHODS: Sixty healthy mice were randomly divided into six groups: the NC group, the Sham group, the Sham + Gyp-XLIX group, the CLP group, the CLP + Gyp-XLIX group, and the CLP + Dexamethasone (DEX) group. The NC group did not undergo any operation, while the rest of the groups underwent CLP to establish the sepsis model...
December 23, 2023: International Immunopharmacology
https://read.qxmd.com/read/38110141/adelmidrol-ameliorates-liver-ischemia-reperfusion-injury-through-activating-nrf2-signaling-pathway
#27
JOURNAL ARTICLE
Min Wu, Xudong Liu, Qiwen Yu, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Liver ischemia/reperfusion (I/R) injury commonly occurs after various liver surgeries. Adelmidrol, an N- palmitoylethanolamide analog, has anti-inflammatory, anti-oxidant, and anti-injury properties. To investigate whether adelmidrol could reduce liver I/R injury, we established a mouse of liver I/R injury and an AML12 cell hypoxia-reoxygenation model to perform experiments using multiple indicators. Serum ALT and AST levels, and H&E staining were used to measure liver damage; MDA content, superoxide dismutase and glutathione activities, and dihydroethidium staining were used to measure oxidative stress; mRNA expression levels of tumor necrosis factor-α, interleukin(IL)-1β, IL-6, MCP-1, and Ly6G staining were used to measure inflammatory response; and protein expression of Bax, Bcl-2, C-caspase3, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining were used to measure apoptosis...
December 16, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/38071319/bactericidal-effect-of-low-temperature-atmospheric-plasma-against-the-shigella-flexneri
#28
JOURNAL ARTICLE
Yan Chen, Yuanyuan He, Tao Jin, Chenwei Dai, Qinghua Xu, Zhengwei Wu
BACKGROUND: Shigella flexneri (S. flexneri) is a common intestinal pathogenic bacteria that mainly causes bacillary dysentery, especially in low socioeconomic countries. This study aimed to apply cold atmospheric plasma (CAP) on S. flexneri directly to achieve rapid, efficient and environmentally friendly sterilization. METHODS: The operating parameters of the equipment were determined by plasma diagnostics. The plate count and transmission electron microscope were employed to calculate bacterial mortality rates and observe the morphological damage of bacterial cells...
December 9, 2023: Biomedical Engineering Online
https://read.qxmd.com/read/38023700/low-intensity-pulsed-ultrasound-alleviates-doxorubicin-induced-cardiotoxicity-via-inhibition-of-s100a8-a9-mediated-cardiac-recruitment-of-neutrophils
#29
JOURNAL ARTICLE
Hong Zhu, Min He, Yong-Li Wang, Yuanxin Zhang, Jingsong Dong, Bo-Yan Chen, Yu-Lin Li, Lu-Jun Zhou, Lin-Juan Du, Yuan Liu, Wu-Chang Zhang, Dean Ta, Sheng-Zhong Duan
Doxorubicin (DOX)-induced cardiotoxicity limits its broad use as a chemotherapy agent. The development of effective and non-invasive strategies to prevent DOX-associated adverse cardiac events is urgently needed. We aimed to examine whether and how low-intensity pulsed ultrasound (LIPUS) plays a protective role in DOX-induced cardiotoxicity. Male C57BL/6J mice were used to establish models of both acute and chronic DOX-induced cardiomyopathy. Non-invasive LIPUS therapy was conducted for four consecutive days after DOX administration...
November 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/37995896/histone-deacetylase-9-exacerbates-podocyte-injury-in-hyperhomocysteinemia-through-epigenetic-repression-of-klotho
#30
JOURNAL ARTICLE
Min Liu, Yang Zhang, Ping Zhan, Wenjuan Sun, Chuanqiao Dong, Xiaohan Liu, Yujie Yang, Xiaojie Wang, Yusheng Xie, Chengjiang Gao, Huili Hu, Benkang Shi, Ziying Wang, Chun Guo, Fan Yi
Although hyperhomocysteinemia (hHcys) has been recognized as an important independent risk factor in the progression of end-stage renal disease and the development of cardiovascular complications related to end-stage renal disease, the mechanisms triggering pathogenic actions of hHcys are not fully understood. The present study was mainly designed to investigate the role of HDACs in renal injury induced by hHcys. Firstly, we identified the expression patterns of HDACs and found that, among zinc-dependent HDACs, HDAC9 was preferentially upregulated in the kidney from mice with hHcys...
November 21, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37994671/the-phosphokinase-activity-of-ire1%C3%A9-prevents-the-oxidative-stress-injury-through-mir-25-nox4-pathway-after-ich
#31
JOURNAL ARTICLE
Yuhui Liao, Juan Huang, Zhenhua Wang, Zhengyu Yang, Yue Shu, Shengwei Gan, Zhixu Wang, Weitian Lu
BACKGROUND: Endoplasmic reticulum (ER) stress and oxidative stress are the major pathologies encountered after intracerebral hemorrhage (ICH). Inositol-requiring enzyme-1 alpha (IRE1α) is the most evolutionarily conserved ER stress sensor, which plays a role in monitoring and responding to the accumulation of unfolded/misfolded proteins in the ER lumen. Recent studies have shown that ER stress is profoundly related to oxidative stress in physiological or pathological conditions...
November 23, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37976794/extracts-from-dendropanax-morbifera-leaves-ameliorates-cerebral-ischemia-induced-hippocampal-damage-by-reducing-oxidative-damage-in-gerbil
#32
JOURNAL ARTICLE
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, Dae Young Yoo, Min Soo Kang, Jung Hoon Choi, Seung Myung Moon, Dae Won Kim, In Koo Hwang
AIM: In this study, we investigated the effects of Dendropanax morbifera extract (DME) on neuroprotection against ischemic damage in gerbils. METHODS: DME (100 or 300 mg/kg) was orally administered to gerbils for three weeks, and 2 h after the last DME treatment, transient forebrain ischemia in the common carotid arteries was induced for 5 min. The forebrain ischemia-related cognitive impairments were assessed by spontaneous motor activity and passive avoidance test one and four days after ischemia, respectively...
November 15, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/37976004/canagliflozin-ameliorates-high-glucose-induced-apoptosis-in-nrk-52e-cells-via-inhibiting-oxidative-stress-and-activating-ampk-mtor-mediated-autophagy
#33
JOURNAL ARTICLE
Hong Liu, Weidong Chen, Sheng Wan, Ye Chen, Mengjing Fu, Zengsi Wang, Fei Xiong, Yanmin Zhang
BACKGROUND: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, as a new type of hypoglycemic drug, can prevent proximal renal tubule injury related to glucose toxicity and play a renoprotective role. Canagliflozin, a recognized SGLT-2 inhibitor, has been proved to have potential protection in diabetic nephropathy (DN), but its mechanism has not been fully elucidated. In this study, the protective effect of canagliflozin against high glucose (HG)-induced renal tubular epithelial cell (NRK-52E) injury in vitro was assessed...
November 17, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37975594/endogenous-hydrogen-sulphide-deficiency-and-exogenous-hydrogen-sulphide-supplement-regulate-skin-fibroblasts-proliferation-via-necroptosis
#34
JOURNAL ARTICLE
Ling Li, Xudong Chen, Chang Liu, Ziying He, Qiyan Shen, Yue Zhu, Xin Wang, Shuanglin Cao, Shengju Yang
An excessive proliferation of skin fibroblasts usually results in different skin fibrotic diseases. Hydrogen sulphide (H2 S) is regarded as an important endogenous gasotransmitter with various functions. The study aimed to investigate the roles and mechanisms of H2 S on primary mice skin fibroblasts proliferation. Cell proliferation and collagen synthesis were assessed with the expression of α-smooth muscle actin (α-SMA), proliferating cell nuclear antigen (PCNA), Collagen I and Collagen III. The degree of oxidative stress was evaluated by dihydroethidium (DHE) and MitoSOX staining...
November 17, 2023: Experimental Dermatology
https://read.qxmd.com/read/37972749/high-fat-diet-causes-endothelial-dysfunction-in-the-mouse-ophthalmic-artery
#35
JOURNAL ARTICLE
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W Böhm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Obesity is a significant health concern that leads to impaired vascular function and subsequent abnormalities in various organs. The impact of obesity on ocular blood vessels, however, remains largely unclear. In this study, we examined the hypothesis that obesity induced by high-fat diet produces vascular endothelial dysfunction in the ophthalmic artery. Mice were subjected to a high-fat diet for 20 weeks, while age-matched controls were maintained on a standard diet. Reactivity of isolated ophthalmic artery segments was assessed in vitro...
November 14, 2023: Experimental Eye Research
https://read.qxmd.com/read/37934907/radioprotective-effect-of-ginkgolide-b-on-brain-the-mediating-role-of-dcc-mst1-signaling
#36
JOURNAL ARTICLE
Tao Yang, Xiao Du, Lixing Xu
PURPOSE: The risk of brain exposure to ionizing radiation increases gradually due to the extensive application of nuclear technology in medical, industrial, and aerospace fields. Radiation-induced brain injury (RBI) is highly likely to cause a wide range of neurological complications, including schizophrenia, Alzheimer's disease (AD), depression. Ginkgolide B (GB) is one of the effective active components extracted from ginkgo biloba leaves, exerts protective effects on CNS, which involved in the regulation of Hippo signaling pathway...
November 7, 2023: International Journal of Radiation Biology
https://read.qxmd.com/read/37918281/radix-astragali-decoction-improves-liver-regeneration-by-upregulating-hepatic-expression-of-aquaporin-9
#37
JOURNAL ARTICLE
Yanghao Li, Xu Yang, Tiantian Bao, Xiaojuan Sun, Xiang Li, Huilin Zhu, Bo Zhang, Tonghui Ma
BACKGROUND: The therapeutic efficacy of liver injuries heavily relies on the liver's remarkable regenerative capacity, necessitating the maintenance of glycose/lipids homeostasis and oxidative eustasis during the recovery process. Astragali Radix, an herbal tonic widely used in China and many other countries, is believed to have many positive effects, including immune stimulation, nourishing, antioxidant, liver protection, diuresis, anti-diabetes, anti-cancer and expectorant. Astragali Radix is widely integrated into hepatoprotective formulas as it is believed to facilitate liver regeneration...
October 25, 2023: Phytomedicine
https://read.qxmd.com/read/37891811/daytime-restricted-feeding-ameliorates-oxidative-stress-by-increasing-nrf2-transcriptional-factor-in-the-rat-hippocampus-in-the-pilocarpine-induced-acute-seizure-model
#38
JOURNAL ARTICLE
Octavio Fabián Mercado-Gómez, Virginia Selene Arriaga-Ávila, Angélica Vega-García, Sandra Orozco-Suarez, Vadim Pérez-Koldenkova, Juan José Camarillo-Sánchez, Marcelino Álvarez-Herrera, Rosalinda Guevara-Guzmán
Seizure-mediated oxidative stress is a crucial mechanism in the pathophysiology of epilepsy. This study evaluated the antioxidant effects of daytime-restricted feeding (DRF) and the role of the Nrf2 signaling pathway in a lithium-pilocarpine model seizure model that induces status epilepticus (SE). We performed a lipoperoxidation assay and dihydroethidium fluorescence to measure oxidative stress markers in the hippocampus (malondialdehyde and reactive oxygen species). The protein content of Nrf2 and its downstream protein SOD2 was evaluated using Western blotting...
October 10, 2023: Brain Sciences
https://read.qxmd.com/read/37858664/grape-seed-proanthocyanidins-regulate-mitophagy-of-endothelial-cells-and-promote-wound-healing-in-mice-through-p-jnk-foxo3a-ros-signal-pathway
#39
JOURNAL ARTICLE
Liuqing Chen, Li Hao, Chen Yanshuo, Wu FangFang, Chen Daqin, Xia Weidong, Xiao Jian, Chen Shaodong, Zhang Hongyu, Xu Ke
Skin wound healing is a dynamic and complex process that involves multiple physiological and cellular events. Grape seed proanthocyanidins (GSP) have strong anti-oxidation and elimination of oxygen free radicals, and have been shown to significantly promote wound healing, but the underlying mechanism remains unclear. Studies have indicated that reactive oxygen species (ROS) acts as an upstream signal to induce mitophagy, suggesting that GSP can regulate mitophagy through the signal pathway. This study aimed to investigate whether GSP regulates mitophagy by down-regulating oxidative stress to promote wound healing...
October 17, 2023: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/37854382/effect-of-mir-27b-3p-and-nrf2-in-human-retinal-pigment-epithelial-cell-induced-by-high-glucose
#40
JOURNAL ARTICLE
Qiao-Ling Lai, Ting Xie, Wei-Dong Zheng, Yan Huang
AIM: To determine whether the microRNA-27b-3p (miR-27b-3p)/NF-E2-related factor 2 (Nrf2) pathway plays a role in human retinal pigment epithelial (hRPE) cell response to high glucose, how miR-27b-3p and Nrf2 expression are regulated, and whether this pathway could be specifically targeted. METHODS: hRPE cells were cultured in normal glucose or high glucose for 1, 3, or 6d before measuring cellular proliferation rates using cell counting kit-8 and reactive oxygen species (ROS) levels using a dihydroethidium kit...
2023: International Journal of Ophthalmology
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