Eleni Rebelos, Aino Latva-Rasku, Kalle Koskensalo, Laura Pekkarinen, Ekaterina Saukko, Jukka Ihalainen, Miikka-Juhani Honka, Jouni Tuisku, Marco Bucci, Sanna Laurila, Johan Rajander, Paulina Salminen, Lauri Nummenmaa, Jacobus Fa Jansen, Ele Ferrannini, Pirjo Nuutila
The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy (1 H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET)) was also performed in a subset of subjects during clamp...
October 12, 2023: Journal of Cerebral Blood Flow and Metabolism