keyword
https://read.qxmd.com/read/38169709/altered-metabolism-in-right-basal-ganglia-associated-with-asymptomatic-neurocognitive-impairment-in-hiv-infected-individuals
#21
JOURNAL ARTICLE
Yi Zhan, Dan-Chao Cai, Ying Liu, Fengxiang Song, Fei Shan, Pengrui Song, Guochao Chen, Yijun Zhang, He Wang, Yuxin Shi
BACKGROUND: Only few studies have focused on the metabolite differences between asymptomatic neurocognitive impairment (ANI) and cognitively normal people living with HIV (PLWH). The current study aims to examine whether brain metabolisms in basal ganglia (BG) by magnetic resonance spectroscopy (MRS) were potential to discriminate ANI from cognitively normal PLWH. METHODS: According to neuropsychological (NP) test, 80 PLWH (37.4 ± 10.2 years) were divided into ANI group (HIV-ANI, n = 31) and NP normal group (HIV-normal, n = 49)...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38156270/reduced-gaba-concentration-in-patients-with-white-matter-hyperintensities
#22
JOURNAL ARTICLE
Xin Wang, Caihong Wang, Peifang Miao, Ying Wei, Liangjie Lin, Zhen Li, Yong Zhang, Jingliang Cheng, Cuiping Ren
To investigate potential alterations of white matter hyperintensities (WMHs) on J -edited MR spectroscopy (MRS) measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA). Twenty-four WMHs patients and 20 healthy controls (HCs) were recruited to undergo magnetic resonance spectroscopy (MRS) scan at 3T from voxels in left centrum semiovale white matter, using the MEGA point resolved spectroscopy (MEGA-PRESS) technique with the MATLAB-based Gannet tool to estimate GABA+ co-edited macromolecule (GABA+) levels and using Tarquin software to estimate levels of glutamate + glutamine (Glx), total N-acetylaspartate (tNAA), total choline (tCho), and total creatine (tCr)...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/38148181/single-shot-diffusion-trace-weighted-mr-spectroscopy-comparison-with-unipolar-and-bipolar-diffusion-weighted-point-resolved-spectroscopy
#23
JOURNAL ARTICLE
Andres Saucedo, James Sayre, M Albert Thomas
This study demonstrates the feasibility and performance of the point-resolved spectroscopy (PRESS)-based, single-shot diffusion trace-weighted sequence in quantifying the trace apparent diffusion coefficient (ADC) in phantom and in vivo using a 3-T MRI/MRS scanner. The single-shot diffusion trace-weighted PRESS sequence was implemented and compared with conventional diffusion-weighted (DW)-PRESS variants using bipolar and unipolar diffusion-sensitizing gradients. Nine phantom datasets were acquired using each sequence, and seven volunteers were scanned in three different brain regions to determine the range and variability of trace ADC values, and to allow a comparison of trace ADCs among the sequences...
December 26, 2023: NMR in Biomedicine
https://read.qxmd.com/read/38147791/investigating-neural-dysfunction-with-abnormal-protein-deposition-in-alzheimer-s-disease-through-magnetic-resonance-spectroscopic-imaging-plasma-biomarkers-and-positron-emission-tomography
#24
JOURNAL ARTICLE
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
In Alzheimer's disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction in the human brain. To clarify the relationship between neuronal dysfunction and abnormal proteins in AD-affected brains, we conducted magnetic resonance spectroscopic imaging (MRSI) and assessed the neurofilament light chain plasma levels (NfL). We evaluated tau and amyloid-β depositions using standardized uptake value ratios (SUVRs) of florzolotau (18F) for tau and 11 C-PiB for amyloid-β positron emission tomography in the same patients...
December 22, 2023: NeuroImage: Clinical
https://read.qxmd.com/read/38146590/effects-of-sulfatide-on-peripheral-nerves-in-metachromatic-leukodystrophy
#25
JOURNAL ARTICLE
Mohamed H Farah, Christine Í Dali, Samuel Groeschel, Mihai Moldovan, David A H Whiteman, C J Malanga, Ingeborg Krägeloh-Mann, Jing Li, Norman Barton, Christian Krarup
OBJECTIVE: To evaluate the longitudinal correlations between sulfatide/lysosulfatide levels and central and peripheral nervous system function in children with metachromatic leukodystrophy (MLD) and to explore the impact of intravenous recombinant human arylsulfatase A (rhASA) treatment on myelin turnover. METHODS: A Phase 1/2 study of intravenous rhASA investigated cerebrospinal fluid (CSF) and sural nerve sulfatide levels, 88-item Gross Motor Function Measure (GMFM-88) total score, sensory and motor nerve conduction, brain N-acetylaspartate (NAA) levels, and sural nerve histology in 13 children with MLD...
February 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38137114/cortical-gaba-levels-are-reduced-in-post-acute-covid-19-syndrome
#26
JOURNAL ARTICLE
Ksenija Marinkovic, David R White, Austin Alderson Myers, Katie S Parker, Donatello Arienzo, Graeme F Mason
After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing post-acute sequelae of COVID-19 (PASC), also termed "long COVID". Their quality of life is adversely impacted by persistent cognitive dysfunction and affective distress, but the underlying neural mechanisms are poorly understood. The present study recruited a group of mostly young, previously healthy adults (24.4 ± 5.2 years of age) who experienced PASC for almost 6 months following a mild acute COVID-19 illness...
December 1, 2023: Brain Sciences
https://read.qxmd.com/read/38089686/no-neuroprotective-effect-of-therapeutic-hypothermia-following-lipopolysaccharide-sensitized-hypoxia-ischemia-a-newborn-piglet-study
#27
JOURNAL ARTICLE
Mads Andersen, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, Leslie Schwendimann, Pierre Gressens, Kasper Jacobsen Kyng, Tine Brink Henriksen
INTRODUCTION: Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection. METHODS: A total of 32 male and female piglets were included in this randomized experimental study...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38077237/peripheral-and-central-nervous-system-biomarkers-of-inflammation-in-functional-seizures-assessment-with-magnetic-resonance-spectroscopy
#28
JOURNAL ARTICLE
Christina Mueller, Ayushe A Sharma, Jerzy P Szaflarski
PURPOSE: Inflammation may link trauma to clinical symptoms in functional seizures (FS). We compared brain temperature and metabolites in FS, psychiatric (PCs) and healthy controls (HCs) and quantified their associations with serum biomarkers of inflammation and clinical symptoms. PATIENTS AND METHODS: Brain temperature and metabolites were measured with whole-brain magnetic resonance spectroscopic imaging (MRSI) and compared between groups in regions of interest and the whole brain...
2023: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38065860/characteristic-early-changes-of-glu-and-cho-in-brain-regions-affected-by-different-types-of-subjective-cognitive-decline-and-their-clinical-significance
#29
JOURNAL ARTICLE
Zhen Zeng, Jing He, Tao Yao
To discuss the early changes of Glu and Cho in the affected areas of different types of subjective cognitive decline, including amnestic MCI (aMCl), non-amnestic MCI (naMCI) and vascular cognitive impairment no dementia (VCIND), using Proton Magnetic Resonance Spectroscopy (1H-MRS) technology. Routine head MRI and lH-MRS examinations were performed on 50 clearly diagnosed aMCI patients, 44 naMCI patients, 44 VCIND patients, and 44 elderly individuals with normal cognitive function. Measure the volume of the patient bilateral hippocampus...
December 8, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38028102/management-strategy-in-actinomycosis-brain-abscess
#30
Mohamed Dehmani Yedeas, Mohamed Amine Rachdi, Souheil Zayet, Rahma Yaiche, Ridha Chkili
We reported herein a case of isolated cerebral actinomycosis in a 54-year-old immunocompetent man. Brain MRI showed a left frontal intra-axial lesion and perilesional edema. We performed an open biopsy of the left frontal enhancing lesion. Intraoperative findings showed a yellowish, malleable, and capsulated lesion that was well defined with surrounding normal tissue within pus inside and lacked any necrotic content. MR spectroscopy showed a high level of choline, lactate, and lipid peaks with a choline/N-Acetylaspartic acid ratio of 1...
November 2023: Clinical Case Reports
https://read.qxmd.com/read/38011891/naag-synthetase-deficiency-has-only-low-influence-on-pathogenesis-in-a-canavan-disease-mouse-model
#31
JOURNAL ARTICLE
Ivonne Becker, Lihua Wang-Eckhardt, Matthias Eckhardt
Canavan disease (CD) is a leukodystrophy caused by mutations in the N-acetylaspartate (NAA) hydrolase aspartoacylase (ASPA). Inability to degrade NAA and its accumulation in the brain results in spongiform myelin degeneration. NAA is mainly synthesized by neurons, where it is also a precursor of the neuropeptide N-acetylaspartylglutamate (NAAG). Hydrolysis of this peptide by glutamate carboxypeptidases is an additional source of extracellular NAA besides the instant neuronal release of NAA. This study examines to what extent NAA released from NAAG contributes to NAA accumulation and pathogenesis in the brain of Aspanur7/nur7 mutant mice, an established model of CD...
November 27, 2023: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/38009673/abnormal-axonal-development-and-severe-epileptic-phenotype-in-dynamin-1-dnm1-encephalopathy
#32
JOURNAL ARTICLE
Kohei Matsubara, Ichiro Kuki, Risako Ishioka, Naoki Yamada, Masataka Fukuoka, Takeshi Inoue, Megumi Nukui, Nobuhiko Okamoto, Takeshi Mizuguchi, Naomichi Matsumoto, Shin Okazaki
Dynamin-1 (DNM1) is involved in synaptic vesicle recycling, and DNM1 mutations can lead to developmental and epileptic encephalopathy. The neuroimaging of DNM1 encephalopathy has not been reported in detail. We describe a severe phenotype of DNM1 encephalopathy showing characteristic neuroradiological features. In addition, we reviewed previously reported cases who have DNM1 pathogenic variants with white matter abnormalities. Our case presented drug-resistant seizures from 1 month of age and epileptic spasms at 2 years of age...
November 27, 2023: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/37964218/evaluation-of-the-diagnostic-utility-on-1-5t-and-3-0t-1-h-magnetic-resonance-spectroscopy-for-temporal-lobe-epilepsy
#33
JOURNAL ARTICLE
Biao Qu, Hejuan Tan, Min Xiao, Dongbao Liu, Shijin Wang, Yiwen Zhang, Runhan Chen, Gaofeng Zheng, Yonggui Yang, Gen Yan, Xiaobo Qu
BACKGROUND: 1 H magnetic resonance spectroscopy (1 H-MRS) can be used to study neurological disorders because it can be utilized to examine the concentrations of related metabolites. However, the diagnostic utility of different field strengths for temporal lobe epilepsy (TLE) remains unclear. The purpose of this study is to make quantitative comparisons of metabolites of TLE at 1.5T and 3.0T and evaluate their efficacy. METHODS: Our retrospective collections included the single-voxel 1 H-MRS of 23 TLE patients and 17 healthy control volunteers (HCs) with a 1...
November 14, 2023: BMC Medical Imaging
https://read.qxmd.com/read/37917311/brain-metabolite-levels-in-remitted-psychotic-depression-with-consideration-of-effects-of-antipsychotic-medication
#34
JOURNAL ARTICLE
Hideaki Tani, Iska Moxon-Emre, Natalie J Forde, Nicholas H Neufeld, Kathleen S Bingham, Ellen M Whyte, Barnett S Meyers, George S Alexopoulos, Matthew J Hoptman, Anthony J Rothschild, Hiroyuki Uchida, Alastair J Flint, Benoit H Mulsant, Aristotle N Voineskos
BACKGROUND: The neurobiology of psychotic depression is not well understood and can be confounded by antipsychotics. Magnetic resonance spectroscopy (MRS) is an ideal tool to measure brain metabolites non-invasively. We cross-sectionally assessed brain metabolites in patients with remitted psychotic depression and controls. We also longitudinally assessed the effects of olanzapine versus placebo on brain metabolites. METHODS: Following remission, patients with psychotic depression were randomized to continue sertraline + olanzapine (n = 15) or switched to sertraline + placebo (n = 18), at which point they completed an MRS scan...
November 2, 2023: Brain Imaging and Behavior
https://read.qxmd.com/read/37909379/changes-in-aspartate-metabolism-in-the-medial-prefrontal-cortex-of-nicotine-addicts-based-on-j-edited-magnetic-resonance-spectroscopy
#35
JOURNAL ARTICLE
Miaomiao Yu, Liangjie Lin, Ke Xu, Man Xu, Jianxin Ren, Xiaoyu Niu, Xinyu Gao, Mengzhe Zhang, Zhengui Yang, Jinghan Dang, Qiuying Tao, Shaoqiang Han, Weijian Wang, Jingliang Cheng, Yong Zhang
This study aims to explore the changes of the aspartate (Asp) level in the medial-prefrontal cortex (mPFC) of subjects with nicotine addiction (nicotine addicts [NAs]) using the J-edited 1 H MR spectroscopy (MRS), which may provide a positive imaging evidence for intervention of NA. From March to August 2022, 45 males aged 40-60 years old were recruited from Henan Province, including 21 in NA and 24 in nonsmoker groups. All subjects underwent routine magnetic resonance imaging (MRI) and J-edited MRS scans on a 3...
November 1, 2023: Human Brain Mapping
https://read.qxmd.com/read/37908148/the-effect-of-contact-collision-sport-participation-without-concussion-on-neurometabolites-a-systematic-review-and-meta-analysis-of-magnetic-resonance-spectroscopy-studies
#36
REVIEW
Nathan Delang, Christopher Irwin, Aimie L Peek, Iain S McGregor, Ben Desbrow, Danielle McCartney
The aim of this study was to systematically review prior research investigating the effects of contact/collision sport participation on neurometabolite levels in the absence of concussion. Four online databases were searched to identify studies that measured neurometabolite levels in contact/collision sport athletes (without concussion) using proton (1 H) or phosphorus (31 P) magnetic resonance spectroscopy (MRS). All study designs were acceptable for inclusion. Meta-analytic procedures were used to quantify the effect of contact/collision sport participation on neurometabolite levels and explore the impact of specific moderating factors (where sufficient data were available)...
October 31, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/37885832/preliminary-mrs-study-of-critical-values-of-relevant-brain-metabolites-in-elderly-chinese-patients-with-post-stroke-cognitive-impairment
#37
JOURNAL ARTICLE
MengQi Li, LingLing Yao, ZengXin Lu, LiMing Yang, Hong Fan
OBJECTIVE: Proton magnetic resonance spectroscopy (1 H-MRS) was applied in this study to detect metabolite changes in the brain of post-stroke cognitive impairment (PSCI) and normal volunteers. The levels of N-acetylaspartate (NAA) and creatinine (Cr) and in the frontal lobe, hippocampus and cingulate gyrus were measured to distinguish patients with post-stroke cognitive impairment (PSCI) and normal control group (NC). The relationship between them and cognitive function was explored and a critical value of the metabolite ratio was predicted...
December 2023: IBRO neuroscience reports
https://read.qxmd.com/read/37861526/longitudinal-cognitive-function-and-brain-metabolites-in-women-receiving-chemotherapy-for-stage-1-to-3-breast-cancer-observational-study
#38
JOURNAL ARTICLE
Joana Beyer, Ronan Couch, Kathryn J Ruddy, Burcu Zeydan, Nirubol Tosakulwong, Timothy G Lesnick, Paul J Novotny, Sadhna Kohli, Jane H Cerhan, Sandhya Pruthi, Kejal Kantarci, Firat Kara
Few proton magnetic resonance spectroscopy studies have explored chemotherapy-related biochemical changes in brain regions. This observational study aimed to longitudinally assess short-term cognitive changes and brain metabolite concentrations in women undergoing chemotherapy for breast cancer. We analyzed 11 women with newly diagnosed stage 1 to 3 breast cancer. Patients were evaluated via objective cognitive testing, and patient self-report tests. Patients were examined using single voxel proton magnetic resonance spectroscopy in the medial frontal cortex, posterior cingulate gyrus, and left thalamus at baseline and after the completion of chemotherapy on a 1...
October 20, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37834217/metabolomic-signatures-of-alzheimer-s-disease-indicate-brain-region-specific-neurodegenerative-progression
#39
JOURNAL ARTICLE
Mirela Ambeskovic, Giselle Hopkins, Tanzi Hoover, Jeffrey T Joseph, Tony Montina, Gerlinde A S Metz
Pathological mechanisms contributing to Alzheimer's disease (AD) are still elusive. Here, we identified the metabolic signatures of AD in human post-mortem brains. Using 1 H NMR spectroscopy and an untargeted metabolomics approach, we identified (1) metabolomic profiles of AD and age-matched healthy subjects in post-mortem brain tissue, and (2) region-common and region-unique metabolome alterations and biochemical pathways across eight brain regions revealed that BA9 was the most affected. Phenylalanine and phosphorylcholine were mainly downregulated, suggesting altered neurotransmitter synthesis...
September 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37824728/insulin-stimulated-brain-glucose-uptake-correlates-with-brain-metabolites-in-severe-obesity-a-combined-neuroimaging-study
#40
JOURNAL ARTICLE
Eleni Rebelos, Aino Latva-Rasku, Kalle Koskensalo, Laura Pekkarinen, Ekaterina Saukko, Jukka Ihalainen, Miikka-Juhani Honka, Jouni Tuisku, Marco Bucci, Sanna Laurila, Johan Rajander, Paulina Salminen, Lauri Nummenmaa, Jacobus Fa Jansen, Ele Ferrannini, Pirjo Nuutila
The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy (1 H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET)) was also performed in a subset of subjects during clamp...
October 12, 2023: Journal of Cerebral Blood Flow and Metabolism
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