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y-box binding protein 1

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https://www.readbyqxmd.com/read/29768255/asiatic-acid-aa-sensitizes-multidrug-resistant-human-lung-adenocarcinoma-a549-ddp-cells-to-cisplatin-ddp-via-downregulation-of-p-glycoprotein-mdr1-and-its-targets
#1
Qilai Cheng, Meixiang Liao, Haibo Hu, Hongliang Li, Longhuo Wu
BACKGROUND/AIMS: P-glycoprotein (P-gp, i.e., MDR1) is associated with the phenotype of multidrug resistance (MDR) and causes chemotherapy failure in the management of cancers. Searching for effective MDR modulators and combining them with anticancer drugs is a promising strategy against MDR. Asiatic acid (AA), a natural triterpene isolated from the plant Centella asiatica, may have an antitumor activity. The present study assessed the reversing effect of AA on MDR and possible molecular mechanisms of AA action in MDR1-overexpressing cisplatin (DDP)-resistant lung cancer cells, A549/DDP...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29748382/satellite-rna-increases-dna-damage-and-accelerates-tumor-formation-in-mouse-models-of-pancreatic-cancer
#2
Takahiro Kishikawa, Motoyuki Otsuka, Tatsunori Suzuki, Takahiro Seimiya, Kazuma Sekiba, Rei Ishibashi, Eri Tanaka, Motoko Ohno, Mari Yamagami, Kazuhiko Koike
Highly repetitive tandem arrays such as satellite sequences in the centromeric and pericentromeric regions of chromosomes, which were previously considered to be silent, are actively transcribed in various biological processes, including cancers. In the pancreas, this aberrant expression occurs even in Kras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To determine the biological role of satellite RNAs in carcinogenesis in vivo, we constructed mouse major satellite (MajSAT) RNA-expressing transgenic mice...
May 10, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29743296/yb-1-expression-and-phosphorylation-regulate-tumorigenicity-and-invasiveness-in-melanoma-by-influencing-emt
#3
Corinna Kosnopfel, Tobias Sinnberg, Birgit Sauer, Christian Busch, Heike Niessner, Anja Schmitt, Stephan Forchhammer, Cornelia Grimmel, Peter R Mertens, Stephan Hailfinger, Sandra E Dunn, Claus Garbe, Birgit Schittek
Cutaneous melanoma represents one of the most aggressive human tumor entities possessing a high tendency to metastasize. Cancer cells frequently exploit a highly conserved developmental program, the epithelial-to-mesenchymal transition (EMT), to gain migratory and invasive properties promoting their metastatic spread. Cytoplasmic localization of the oncogenic transcription and translation factor Y-box binding protein 1 (YB-1) is a powerful inducer of EMT in breast carcinoma cells. Interestingly, EMT-like processes have also been observed in cutaneous melanoma despite its neural crest origin...
May 9, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29721182/crosstalk-between-akt-signaling-and-cold-shock-proteins-in-mediating-invasive-cell-phenotypes
#4
Raphael Hohlfeld, Sabine Brandt, Anja Bernhardt, Xenia Gorny, Daniel Schindele, Burkhard Jandrig, Martin Schostak, Berend Isermann, Jonathan A Lindquist, Peter R Mertens
Cold shock proteins are up-regulated by cellular stress and orchestrate inflammatory responses, cell proliferation, and differentiation. Enhanced cold shock protein expression promotes malignant cell transformation; up-regulation is detected in most cancers and associated with poor prognosis. Akt1, a serine/threonine kinase, is a potent oncogene, which activates pro-proliferative and anti-apoptotic signaling pathways, and phosphorylates the cold shock domain. Unexpectedly, chicken-YB-1 abrogates PI3K-Akt-dependent oncogenic cell transformation in embryonic fibroblasts...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29712925/the-rna-binding-protein-ybx1-regulates-epidermal-progenitors-at-a-posttranscriptional-level
#5
Eunjeong Kwon, Kristina Todorova, Jun Wang, Rastislav Horos, Kevin K Lee, Victor A Neel, Gian Luca Negri, Poul H Sorensen, Sam W Lee, Matthias W Hentze, Anna Mandinova
The integrity of stratified epithelia depends on the ability of progenitor cells to maintain a balance between proliferation and differentiation. While much is known about the transcriptional pathways underlying progenitor cells' behavior in the epidermis, the role of posttranscriptional regulation by mRNA binding proteins-a rate-limiting step in sculpting the proteome-remains poorly understood. Here we report that the RNA binding protein YBX1 (Y-box binding protein-1) is a critical effector of progenitors' function in the epidermis...
April 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29694248/adar1-attenuates-allogeneic-graft-rejection-by-suppressing-mir-21-biogenesis-in-macrophages-and-promoting-m2-polarization
#6
Junjie Li, Jiangang Xie, Shanshou Liu, Xiao Li, Dongliang Zhang, Xianqi Wang, Jinquan Jiang, Wei Hu, Yuan Zhang, Boquan Jin, Ran Zhuang, Wen Yin
ADAR1 (adenosine deaminase acting on double-stranded RNA 1) is an RNA-editing enzyme that mediates adenosine-to-inosine RNA editing events, an important post-transcriptional modification mechanism that can alter the coding properties of mRNA or regulate microRNA biogenesis. ADAR1 also regulates the innate immune response. Here, we have demonstrated that ADAR1 expression increased in LPS-stimulated macrophages. Silencing ADAR1 by using small interfering RNA in macrophages resulted in the pronounced polarization of macrophages to M1, whereas ADAR1 overexpression promoted M2 polarization, which indicated that ADAR1 can inhibit macrophage hyperpolarization and prevent immune hyperactivity...
April 25, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29670170/y-box-protein-associated-acidic-protein-ybap1-c1qbp-affects-the-localization-and-cytoplasmic-functions-of-yb-1
#7
Ken Matsumoto, Shingo Kose, Iku Kuwahara, Mami Yoshimura, Naoko Imamoto, Minoru Yoshida
The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear level of YB-1 is well correlated with poor prognosis in many human cancers. Previously, we showed that a Y-box protein-associated acidic protein, YBAP1, which is identical to complement component 1, q subcomponent-binding protein (C1QBP, also called gC1qR, hyaluronan-binding protein 1 [HABP1] or ASF/SF2-associated protein p32), relieves translational repression by YB-1...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29590660/the-role-of-y-box-binding-protein-1-in-kidney-injury-friend-or-foe
#8
Ben Ke, Chuqiao Fan, Weiping Tu, Xiangdong Fang
Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes via the transcriptional and translational regulation of target gene expression. YB-1 promotes acute or chronic kidney injury through multiple molecular pathways; however, accumulating evidence suggests that significantly increased YB-1 levels are of great importance in renoprotection. In addition, YB-1 may contribute to obesity-related kidney disease by promoting adipogenesis. Thus, the role of YB-1 in kidney injury is complicated, and no comprehensive review is currently available...
March 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29571909/inhibition-of-sox9-promotes-inflammatory-and-immune-responses-of-dental-pulp
#9
Haiyun Luo, Chenglin Wang, Mengyu Liu, Bei Yin, Peng A, Dingming Huang, Ling Ye
INTRODUCTION: The process of pulpitis is characterized by extracellular matrix imbalance and inflammatory cell infiltration. As an essential transcription factor, sex-determining region Y-box 9 (SOX9) is significantly inhibited by tumor necrosis factor alpha in inflammatory joint diseases. The aim of this study was to explore the role of SOX9 in extracellular matrix balance, cytokine expression, and the immune response in dental pulp. METHODS: The expression of SOX9 in normal and inflamed pulp tissue/human dental pulp cells (HDPCs) was detected by immunohistochemistry, Western blot, and quantitative polymerase chain reaction (qPCR)...
March 20, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29559746/mutant-kras-promotes-liver-metastasis-of-colorectal-cancer-in-part-by-upregulating-the-mek-sp1-dnmt1-mir-137-yb-1-igf-ir-signaling-pathway
#10
Po-Chen Chu, Peng-Chan Lin, Hsing-Yu Wu, Kuen-Tyng Lin, Christina Wu, Tanios Bekaii-Saab, Yih-Jyh Lin, Chung-Ta Lee, Jeng-Chang Lee, Ching-Shih Chen
Although the role of insulin-like growth factor-I receptor (IGF-IR) in promoting colorectal liver metastasis is known, the mechanism by which IGF-IR is upregulated in colorectal cancer (CRC) is not defined. In this study, we obtained evidence that mutant KRAS transcriptionally activates IGF-IR gene expression through Y-box-binding protein (YB)-1 upregulation via a novel MEK-Sp1-DNMT1-miR-137 pathway in CRC cells. The mechanistic link between the tumor suppressive miR-137 and the translational regulation of YB-1 is intriguing because epigenetic silencing of miR-137 represents an early event in colorectal carcinogenesis due to promoter hypermethylation...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29550138/variation-in-x-box-binding-protein-1-xbp1-expression-and-its-dependent-endoplasmic-reticulum-chaperones-does-not-regulate-adiponectin-secretion-in-dairy-cows
#11
C S Krumm, S L Giesy, C L Orndorff, Y R Boisclair
Adiponectin is an insulin-sensitizing hormone produced predominantly by adipose tissue; it circulates as oligomers of 3, 6, 18, or more units. Plasma adiponectin might be involved in the development of insulin resistance in transition dairy cows because it falls to a nadir around parturition. The possibility that this regulation occurs through a post-transcriptional mechanism was suggested in a previous study that showed unchanged adiponectin mRNA abundance combined with reduced expression of endoplasmic reticulum (ER) chaperones implicated in assembly of adiponectin oligomers...
June 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29522763/enhanced-mir-711-transcription-by-ppar%C3%AE-induces-endoplasmic-reticulum-stress-mediated-apoptosis-targeting-calnexin-in-rat-cardiomyocytes-after-myocardial-infarction
#12
Na Zhao, Lan Mi, Xunjun Zhang, Minyao Xu, Haiyi Yu, Zhongwei Liu, Xiaojun Liu, Gongchang Guan, Wei Gao, Junkui Wang
MicroRNA 711 (miR-711) levels in the heart change dynamically after myocardial infarction (MI). As peroxisome proliferator-activated receptor gamma (PPARγ) can upregulate miR-711 in adipocytes and cardiac fibroblasts, this study examined the precise mechanism of PPARγ-mediated miR-711 upregulation and its role in the heart in the early stages after MI. In a rat model of MI induced by left anterior descending coronary artery ligation, immunohistochemical and western blot analyses revealed increased PPARγ expression in cardiomyocyte nuclei after MI...
May 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29517281/yb-1-promotes-laryngeal-squamous-cell-carcinoma-progression-by-inducing-mir-155-expression-via-c-myb
#13
Xudong Zhao, Wei Zhang, Wenyue Ji
AIM: In this study, we investigated the role of Y-box binding protein-1 (YB-1), c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression. MATERIALS & METHODS: Quantitative real-time PCR, western blot, MTT and Transwell were conducted to determine the expression and function of YB-1/miR-155 pathway. Univariate and multivariate analyses were used to determine the prognostic factors. RESULTS: Expression of YB-1, c-Myb and miR-155 was higher in LSCC tissues...
March 8, 2018: Future Oncology
https://www.readbyqxmd.com/read/29500194/an-efficient-platform-for-generating-somatic-point-mutations-with-germline-transmission-in-the-zebrafish-by-crispr-cas9-mediated-gene-editing
#14
Yibo Zhang, Zhiwei Zhang, Wei Ge
Homology-directed recombination (HDR)-mediated genome editing is a powerful approach for both basic functional study and disease modeling. Although some studies have reported HDR-mediated precise editing in nonrodent models, the efficiency of establishing pure mutant animal lines that carry specific amino acid substitutions remains low. Furthermore, because the efficiency of nonhomologous end joining (NHEJ)-induced insertion and deletion (indel) mutations is normally much higher than that of HDR-induced point mutations, it is often difficult to identify the latter in the background of indel mutations...
April 27, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29486702/y-box-binding-protein-1-stimulates-abasic-site-cleavage
#15
E E Alemasova, K N Naumenko, N A Moor, O I Lavrik
Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5' side of the AP site, thereby generating a single-strand DNA break flanked by the 3'-OH and 5'-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs...
December 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29478751/ybx1-at-the-crossroads-of-non-coding-transcriptome-exosomal-and-cytoplasmic-granular-signaling
#16
REVIEW
Padmanaban S Suresh, Rie Tsutsumi, Thejaswini Venkatesh
YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions...
April 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29452418/phf20-collaborates-with-parp1-to-promote-stemness-and-aggressiveness-of-neuroblastoma-cells-through-activation-of-sox2-and-oct4
#17
Wenyong Long, Wei Zhao, Bo Ning, Jing Huang, Junjun Chu, Linfeng Li, Qianquan Ma, Changsheng Xing, Helen Y Wang, Qing Liu, Rong-Fu Wang
The differentiation status of neuroblastoma (NB) strongly correlates with its clinical outcomes; however, the molecular mechanisms driving maintenance of stemness and differentiation remain poorly understood. Here, we show that plant homeodomain finger-containing protein 20 (PHF20) functions as a critical epigenetic regulator in sustaining stem cell-like phenotype of NB by using CRISPR/Cas9-based targeted knockout (KO) for high-throughput screening of gene function in NB cell differentiation. Expression of PHF20 in NB was significantly associated with high aggressiveness of the tumor and poor outcomes for NB patients...
February 14, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29429449/investigation-of-function-and-regulation-of-the-yb-1-cellular-factor-in-hiv-replication
#18
Yu-Mi Jung, Kyung-Lee Yu, Seong-Hyun Park, Seong-Deok Lee, Min-Jeong Kim, Ji-Chang You
Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay...
February 12, 2018: BMB Reports
https://www.readbyqxmd.com/read/29353823/increased-expression-of-y-box-binding-protein-1-in-hind-limb-muscles-during-regeneration-from-ischemic-injury-in-mice
#19
Megumi Fuke, Makoto Narita, Yuko Wada, Tatsuichiro Seto, Kenji Okada, Jun Nakayama, Hiroto Izumi, Ken-Ichi Ito
Critical limb ischemia (CLI) is the most severe complication of peripheral arterial disease (PAD). Understanding the molecular mechanisms underlying tissue repair after CLI is necessary for preventing PAD progression. Y-box binding protein-1 (YB-1) regulates the expression of many genes in response to environmental stresses. We aimed to determine whether YB-1 is involved in ischemic muscle regeneration. A mouse ischemic hind-limb model was generated; namely, the femoral, saphenous, and popliteal arteries in the left hind limb were ligated...
January 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29320940/methylation-mediated-loss-of-sfrp2-enhances-invasiveness-of-non-small-cell-lung-cancer-cells
#20
X Zhang, X Rong, Y Chen, L Su
The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, resulting in increased tumor cell invasion and cancer metastasis. However, the role of SFRPs in the invasion of NSCLC has not been reported. Here we analyzed the regulation of SFRPs in NSCLC cells and its effects on cell invasion...
February 2018: Human & Experimental Toxicology
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