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https://www.readbyqxmd.com/read/29774995/-study-on-the-relationship-between-mct-1-and-p53-in-laryngeal-squamous-cell-carcinoma
#1
Y B Wang, O Xu, R J Zhang, C G Shan
Objective: The aim of this study is to investigate the expression and clinical significance of monocarboxylate transporter 1 (MCT-1) and p53 in laryngeal squamous cell carcinoma (LSCC). Method: Immunohistochemical staining of MCT-1 and p53 was carried out in 41 cases of laryngeal squamous cell carcinoma embedded in paraffin, and the relationship between positive expression and clinicopathological data was evaluated. All data were analyzed by SPSS software (Windows version 21.0). Result: In normal mucosa p53 expression was absent; while, the basal "stem cell" layer is highly enriched in MCT-1...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774993/-preliminary-study-on-the-expression-of-egfrv%C3%A2-and-cxcr4-in-head-and-neck-squamous-cell-carcinoma
#2
H D Zhang, S C Gong, Y Q Liu, S B He, Q X Zhang, M Y Si, Z K Yu
Objective: The aim of this study is to detect the expression of EGFRvⅢ and CXCR4 in HNSCC and to explore its possible mechanism. Method: We selected 60 cases of HNSCC from May 2013 to November 2016 in our hospital for surgical treatment, including 44 cases of laryngeal squamous cell carcinoma, 14 cases of hypopharyngeal squamous cell carcinoma, and 2 cases of nasal squamous cell carcinoma. pTNM staging according to AJCC 2010, Ⅲ stage 17 cases, Ⅳa stage 40 cases, and Ⅳb stage 3 cases; according to tumor differentiation degree: 13 cases of high differentiation, moderately differentiation in 31 cases, and 16 cases of low differentiated; primary tumor, positive lymph node metastasis as the experimental group, and 10 cases of adjacent tissues are taken as control (control group)...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771417/lncrna-fer1l4-suppressed-cancer-cell-growth-and-invasion-in-esophageal-squamous-cell-carcinoma
#3
W Ma, C-Q Zhang, H-L Li, J Gu, G-Y Miao, H-Y Cai, J-K Wang, L-J Zhang, Y-M Song, Y-H Tian, Y-H Song
OBJECTIVE: To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA) FER1L4 on biological behaviors of esophageal squamous cell carcinoma (ESCC) cells, such as proliferation and invasion. PATIENTS AND METHODS: The expressions of FER1L4 were detected in 42 pairs of ESCC tissues and corresponding para-carcinoma tissues and 5 kinds of ESCC cell lines via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Polyethyleneimine (PEI) and liposomes were used for FER1L4 expression or interference elimination assays, respectively...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771416/long-non-coding-rna-duxap8-regulates-proliferation-and-invasion-of-esophageal-squamous-cell-cancer
#4
L-J Xu, X-J Yu, B Wei, H-X Hui, Y Sun, J Dai, X-F Chen
OBJECTIVE: The purpose of this research was to detect the expression of long non-coding RNA DUXAP8 in esophageal cancer, and to explore its underlying mechanism in the development of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: We collected 78 pairs of esophageal cancer tissues and normal adjacent tissues. The mRNA level of DUXAP8 in these esophageal cancer tissues and corresponding adjacent tissues was detected by quantitative Real-time polymerase chain reaction (qRT-PCR)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771045/-the-role-of-autophagy-in-the-invasion-and-metastasis-of-the-squamous-cell-carcinoma-of-head-and-neck
#5
C H Chen, G C Zhu, L M Pi, M Wei, L She, H L Tan, G C Liu, Y Liu, X Zhang
Objective: The aim of this study is to explore the effects of autophagy on the metastasis of the Squamous Cell Carcinoma of Head and Neck (SCCHN) via epithelial to mesenchymal transition (EMT) induced by TGF-β1. Method: Establish the EMT model induced by TGF-β1 in the SCCHN in time/concentration, and the expression of autophagy related protein microtubule associated protein 1 light chain3 (LC3) detected by western blot; Autophagy inhibitor chloroquine (CQ), depressing autophagy, the expression of E-cadherin, cytokeratin, Vimentin and LC3 were examined by Western blot...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770313/management-of-the-axilla-in-metaplastic-breast-carcinoma
#6
Brittany L Murphy, Robert T Fazzio, Tanya L Hoskin, Katrina N Glazebrook, Michael G Keeney, Elizabeth B Habermann, Tina J Hieken
Background: Metaplastic breast cancer (MBC), characterized by admixed epithelial, squamous or mesenchymal elements, constitutes <1% of breast cancers and has a poor prognosis but a paradoxically low reported rate of axillary lymph node (LN) involvement. Due to its rarity, data on appropriate axillary management is lacking, prompting this investigation of LN status and outcomes. Methods: We identified 41 MBC patients treated at our institution 2001-2011 who were followed for a median of 66 months...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29769506/evaluating-the-role-of-immunological-cells-tissue-eosinophils-and-mast-cells-in-progression-of-oral-squamous-cell-carcinoma
#7
S Saxena, A Singh, P Singh, K S Sundaragiri, B Sankhla, A Bhargava
Mast cells and eosinophils are increased in oral squamous cell carcinoma. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of the study was to study the mast cells and eosinophils between normal oral mucosa, leukoplakia and oral squamous cell carcinoma and to study the significance of mast cells in the progression of the lesion. A retrospective study was done on archival tissue received from January 2015 to December 2015, in the Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769413/synergistic-anti-cancer-effects-of-nanocarrier-loaded-with-berberine-and-mirna-122
#8
Lei Li, Xiao Li, Xin Huang, Weilai Jiang, Letian Liu, Chunning Hou, Yanqing Yang, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Guolin Li, Haiming Sun, Limin Mao
We introduced polyethyleneimine-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miRNA122 (miR-122) for the treatment of oral squamous cell carcinoma. BER was stabilized by incorporating PC to form ber -PC. Ber -PC was further electrostatically complexed with miR-122 to yield mr-ber- PC for the co-delivery of BER and miR-122. mr-ber- PC treatment dramatically decreased the level of invasion and migration of oral squamous cell carcinoma cells compared with single drug treatments. This study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anti-cancer drug BER and miR-122 to significantly increase the anti-cancer therapeutic effects...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29768138/knockdown-of-the-prolyl-isomerase-pin1-inhibits-hep-2-cells-growth-migration-and-invasion-by-targeting-%C3%AE-catenin-signaling-pathway
#9
Guoliang Fan, Lin Wang, Jia Xu, Ping Jiang, Wei Wang, Ying Huang, Minggang Lv, Shaoting Liu
Increasing evidence indicates that peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) plays a decisive role in a variety of cancers. Nevertheless, its function in laryngeal squamous cell carcinoma (LSCC) has not been elaborated. The aim of this study is to determine the role of Pin1 in LSCC. Here, we established stably transfected Hep-2 cells with low expression of Pin1. Intriguingly, ability of cell proliferation, migration and invasion was significantly inhibited in Pin1-silenced Hep-2 cells. Similarly, knockdown of Pin1 induced apoptosis of Hep-2 cells, as evidenced by increased expression of cleaved-caspase-3, cleaved-PARP, and bax, and decreased expression of bcl2...
May 16, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29767234/microrna-125a-5p-enhances-the-sensitivity-of-esophageal-squamous-cell-carcinoma-cells-to-cisplatin-by-suppressing-the-activation-of-the-stat3-signaling-pathway
#10
Yan Zhao, Ke Ma, Shujun Yang, Xiaosan Zhang, Feng Wang, Xiaqing Zhang, Hongtao Liu, Qingxia Fan
Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) play a variety of roles in tumor development, progression and chemosensitivity in a wide range of tumors. In this study, we found that miR‑125a‑5p exhibited a low expression in esophageal squamous cell carcinoma (ESCC) tissues and cells, and that its low expression was associated with higher tumor staging and shorter a survival time of patients with ESCC. Moreover, miR‑125a‑5p overexpression contributed to the suppression of cell proliferation, cell cycle arrest, cell apoptosis and a decrease in cell migratory and invasive abilities, whereas the downregulation of miR‑125a‑5p promoted cell proliferation, accelerated cell cycle progression, suppressed apoptosis and enhanced the migratory and invasive abilities of ESCC EC1 and TE1 cells, which may be tightly associated with the epithelial‑mesenchymal transition (EMT) process in ESCC...
May 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29766388/molecular-evolution-of-metaplasia-to-adenocarcinoma-in-the-esophagus
#11
REVIEW
William M Grady, Ming Yu
Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), a condition where the normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. In a minority of individuals, BE can progress to low- and high-grade dysplasia and eventually to intra-mucosal and then invasive carcinoma. BE provides researchers with a unique model to characterize the process by which a carcinoma arises from its precursor lesion. Molecular studies of BE have demonstrated that it is not simply a metaplastic tissue, but rather it harbors frequent alterations that are also present in dysplastic BE and in EAC...
May 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29766306/intraoperative-conversion-does-not-affect-the-oncological-outcomes-of-minimally-invasive-esophagectomy-for-treatment-of-esophageal-cancer
#12
Xue-Hai Liu, Yi Hu, Kun-Kun Li, Ying-Jian Wang, Yao-Guang Jiang, Wei Guo
BACKGROUND: The aim of this study is to summarize the causes and implications of intraoperative conversion from minimally invasive esophagectomy (MIE) to open thoracotomy, and to evaluate the effect on long-term survival. METHODS: There were 293 thoracoscopic esophagectomies for esophageal squamous cell carcinoma (ESCC) of the thoracic esophagus performed by the authors from September 2009 to August 2015. Totally, 257 patients were enrolled in this study. These patients were divided into two groups (those underwent complete MIE and those converted to open thoracotomy) and then compared...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29765826/rates-and-locations-of-regional-metastases-in-sinonasal-malignancies-the-mayo-clinic-experience
#13
Brandon W Peck, Kathryn M Van Abel, Eric J Moore, Daniel L Price
Objectives  The objective of this study was to identify factors that may influence the rate and location of regional metastasis in sinonasal malignancies (SNMs). Design  This is a retrospective review. Setting  This study was set at the single-institution tertiary referral center. Participants  A total of 299 patients were treated for SNMs from 1994 to 2014. Main Outcome Measures  The main outcome measures were incidence and distribution of regional metastases. Results  Several histologic subtypes were treated, with squamous cell carcinoma (28...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29763905/scca-tsgf-and-the-long-non-coding-rna-ac007271-3-are-effective-biomarkers-for-diagnosing-oral-squamous-cell-carcinoma
#14
Tingru Shao, Jiaxin Huang, Zenan Zheng, Qingqing Wu, Tiancai Liu, Xiaozhi Lv
BACKGROUND/AIMS: Oral squamous cell carcinoma (OSCC) is one of the most lethal malignancies worldwide and the most common type of oral cancer, characterized by invasive growth, frequent regional metastases, high recurrence, and poor prognosis. In the current study, we investigated the use of long non-coding RNAs (lncRNAs), tumor-specific growth factor (TSGF), and squamous cell carcinoma antigen (SCCA) as potential biomarkers for OSCC screening. METHODS: LncRNA expression was measured by microarray analysis in three sets of OSCC and paired normal mucosal tissues...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763634/novel-long-noncoding-rna-nmr-promotes-tumor-progression-via-nsun2-and-bptf-in-esophageal-squamous-cell-carcinoma
#15
Yuan Li, Jiagen Li, Mei Luo, Chengcheng Zhou, Xuejiao Shi, Wenhui Yang, Zhiliang Lu, Zhaoli Chen, Nan Sun, Jie He
Long noncoding RNAs (lncRNA) have been implicated in cancer but most of them remain largely unstudied. Here, we identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. Upregulation of NMR correlated with tumor metastasis and indicated poor overall survival in ESCC patients. Functionally, NMR could promote tumor cell migration and invasion, inhibit cisplatin-induced apoptosis and increase drug resistance in ESCC cells...
May 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29763491/penile-squamous-cell-carcinoma-with-urethral-extension-treated-with-mohs-micrographic-surgery
#16
Ardeshir E Nadimi, Ali Hendi
Penile squamous cell carcinoma (SCC) with considerable urethral extension is uncommon and difficult to manage. It often is resistant to less invasive and nonsurgical treatments and frequently results in partial or total penectomy, which can lead to cosmetic disfigurement, functional issues, and psychological distress. We report a case of penile SCC in situ with considerable urethral extension with a focus of cells suspicious for moderately well-differentiated and invasive SCC that was treated with Mohs micrographic surgery (MMS)...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29761910/irx5-promotes-nf-%C3%AE%C2%BAb-signalling-to-increase-proliferation-migration-and-invasion-via-opn-in-tongue-squamous-cell-carcinoma
#17
Liyuan Huang, Fangfang Song, Hualing Sun, Lu Zhang, Cui Huang
Iroquois homeobox gene 5 (Irx5) is a highly conserved member of the Iroquois homeobox gene family. Members of this family play distinct and overlapping roles in normal embryonic cell patterning and development of malignancies. In this study, we observed that IRX5 was abnormally abundant in tongue squamous cell carcinoma (TSCC) tissues and cell lines. We used gain- and loss-of-function methods to overexpress and knockdown IRX5 expression in the TSCC cell line CAL27. Our results elucidated that elevated levels of IRX5 promoted proliferation, migration and invasion of TSCC cells, whereas stable or transient knockdown of IRX5 expression suppressed TSCC cell proliferation, migration and invasion...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29761594/extracellular-interleukin-17f-has-a-protective-effect-in-oral-tongue-squamous-cell-carcinoma
#18
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761586/preoperative-predictors-of-occult-nodal-disease-in-ct1n0-oral-cavity-squamous-cell-carcinoma-review-of-2623-cases
#19
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761225/pathological-characteristics-and-prognostic-indicators-of-different-histopathological-types-of-urinary-bladder-cancer-following-radical-cystectomy-in-a-large-single-center-egyptian-cohort
#20
Jeremy W Martin, Simone L Vernez, Yair Lotan, Ahmed Abdelhalim, Rahul Dutta, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Mohamed Ghoneim, Ramy F Youssef
OBJECTIVE: To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. METHODS: A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan-Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS)...
May 14, 2018: World Journal of Urology
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